Optical Result Patents (Class 436/164)
  • Patent number: 8845981
    Abstract: A device for volumetric metering a liquid biologic sample is provided. The device includes an initial chamber, a second chamber, a third chamber, a first valve, a second valve and a third valve. The chambers are each configured so that liquid sample disposed in the respective chamber is subject to capillary forces. Each chamber has a volume, and the volume of the initial chamber is greater than the volume of either the second or the third chambers. The valves each have a burst pressure. The burst pressure of the first valve is greater than the third burst pressure. The first valve is in fluid communication with the second chamber. The second valve is disposed between, and is in fluid communication with, the initial chamber and the third chamber. The third valve is in fluid communication with the third chamber.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 30, 2014
    Assignee: Abbott Point of Care, Inc.
    Inventor: Manav Mehta
  • Publication number: 20140287520
    Abstract: A system and method for the detection of one or more analytes in a collected sample employs capillary action in a sample card containing a sample substrate, at least one test capsule and an absorbent pad. The absorbent pad absorbs the contents of the test capsule and delivers the same to the sample substrate, with the contents of the test capsule chemically reacting with at least one detection reagent to establish an optical indicator for the analyte(s). The sample card can be automatically tested within a reader device, which records and processes an optical signal produced by the chemical reaction and outputs a test result. The collected sample can then be further analyzed using a second device. Additionally, an adhesive component can be provided so that a sample can be collected thereon. Furthermore, the at least one detection reagent can include a surfactant.
    Type: Application
    Filed: June 6, 2014
    Publication date: September 25, 2014
    Inventors: Arman Ghodousi, Sarah Josepha Toal, Gregory Scott Ericksen, Daniel Douglas Montgomery, Thomas Emory McVeigh, Jacek Kotowicz, Sean Conte
  • Patent number: 8841131
    Abstract: A cholesterol-level measuring apparatus including a portable body having a cholesterol level detecting means for identifying a cholesterol level in a blood sample, and a display screen communicatively coupled to the cholesterol level detecting means for illustrating a learned cholesterol level in the blood sample. Notably, the cholesterol level detecting means includes a disposable test strip having a color-changing reactive reagent that changes color in response to the learned cholesterol level in the blood sample.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: September 23, 2014
    Inventor: Ifeanyi Nzeribe
  • Patent number: 8841133
    Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: September 23, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Huan-Ping Wu, Christine D. Nelson
  • Patent number: 8841137
    Abstract: Disclosed is a product that includes an optical sensor; a target-responsive hydrogel matrix on a surface of the optical sensor (where the hydrogel matrix comprises one or more target-specific receptors and one or more target analogs), and one or more high refractive index nanoparticles within the hydrogel matrix, where a detectable change occurs in a refractive index of the hydrogel matrix when contacted with one or more target molecules. Sterile packages and detection devices containing the product, and methods of detecting a target molecule using the product, are also disclosed.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: September 23, 2014
    Assignee: University of Rochester
    Inventors: Lisa DeLouise, Lisa Bonanno
  • Patent number: 8841130
    Abstract: An endometriosis diagnostic in which a biological sample of a female mammal having had a menstrual cycle within 90 days of the biological sample having been obtained from the female mammal is subjected to an in vitro diagnostic procedure in which the biological sample is contacted with an apatite compound for an effective time to provide a responsive visual appearance. Based on the visual appearance, a determination is made whether the female mammal has endometriosis.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: September 23, 2014
    Assignee: Oratel Diagnostics, LLC
    Inventor: Dorothee Goldman
  • Patent number: 8841119
    Abstract: A method of fabricating biochip sensor comprising providing a precursor; depositing the precursor on a substrate to form a coating; and rapid melting/quenching treatment of the coating with an energy source to form micro/nanotextured surface with enhanced reflectance for fast chemiluminescence response of E-Coli bacteria.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: September 23, 2014
    Assignee: Mridangam Research Intellectual Property Trust
    Inventors: Pravansu S. Mohanty, Ramesh K. Guduru
  • Publication number: 20140272946
    Abstract: Methods, systems, and devices for the detection and notification of chemical, biological, radiological, nuclear, and/or explosive agent. The detection and notification system uses aptamers bound to a catalyst that is activated when the aptamer binds to the agent. The activated catalyst acts on a substrate to create a signal that is detected, indicating the presence of the agent. For example, the system can be a glove worn by a user that includes a catalyst/substrate pair that, in the presence of the target agent, produces a colorimetric and/or fluorescent signal in a time-efficient manner.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: SRC, INC.
    Inventors: Adam J. Lowe, Jesse W. Taylor
  • Publication number: 20140273051
    Abstract: An apparatus sensing two or more reactants or analytes in a sample is provided. The apparatus has an one or more light sources emitting energy with two or more detection targets having an immobilized reagent within the target surface. One or more detectors are provided where the two or more detection targets having immobilized reagent thereon are in communication with the sample and the immobilized reagent interacts with the sample. Energy is incident on the targets from the at least one light source such that the energy is changed by the interaction and the change is in turn detected by the at least one detector and associated with a measurement of the level of the reactant or analyte in the sample. A method of making a sensing apparatus and a method of sensing using the sensing apparatus are also disclosed.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Rakesh Reddy, Bruce Johnson, Kevin Doyle
  • Publication number: 20140273052
    Abstract: A sensor system in a water treatment system has a housing, controller, one or more light sources, one or more sensors and one or more targets having an immobilized reagent thereon. Light source emits light energy into the housing that is incident upon the target with the immobilized reagent and the reagent being in contact with water from the system. The immobilized reagent interacts with a reactant in the water such that the interaction changes the state of the reagent. When energy from the light source is incident on the target with the immobilized reagent the energy shows a change detectable by the sensor such that the changed energy is detectable by and collected at the sensor and data on the energy is communicated to the controller. The data is then correlated as a representation of a desired variable to be measured for the water in the water treatment system.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Rakesh Reddy, Bruce Johnson, Kevin Doyle
  • Patent number: 8834796
    Abstract: A chromatographic optical detection system includes an optical detector disposed to receive light scattered from a stream of particles and configured to convert the received light to an electrical signal; a signal-processing unit in signal communication with the optical detector to receive the electrical signal, and configured to convert the electrical signal to digital pulses and count the digital pulses to output a first signal corresponding to a number of particles detected in a time interval, and configured to integrate and digitize the electrical signal to output a second signal corresponding to the number of particles detected in the time interval; and a data station in signal communication with the signal-processing unit, and configured to select the first signal, if the number of particles detected in the time interval is less than a threshold criterion, and to select the second signal if the number of particles detected in the time interval exceeds the threshold criterion.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: September 16, 2014
    Assignee: Waters Technologies Corporation
    Inventor: Joseph A. Jarrell
  • Patent number: 8834795
    Abstract: An optochemical sensor element suitable for sensing an analyte comprises a polymeric material in which at least a portion of the polymer material is solvent crazed to provide a multiplicity of pores of controlled nanometer size, and an indicator dye impregnated into the pores, in which optochemical sensor element the indicator dye is a long-decay photoluminescent dye selected from the group consisting of: phosphorescent platinum(II)—and palladium (II) complexes of porphyrin dyes such as octaethylporphine, coproporphyrin, octaethylporphine-ketone, benzoporphine, tetra (pentafluorophenyl) porphine, chlorin e6; fluorescent complexes of ruthenium (II), osmium(II), iridium(III) and europium (III); or derivatives or close analogs of these dyes. The sensor element in the presence of the analyte alters a photoluminescence parameter thus allowing sensing and/or quantification of the analyte.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: September 16, 2014
    Assignee: Luxcel Biosciences Limited
    Inventors: Olga Vladimirovna Arzhakova, Nikolai Filippovich Bakeev, Aleksandr L'vovich Volynskii, Alla Anatol'evna Dolgova, Larisa Mikhailovna Yarysheva, Ponomarev Gelii Vasilievich
  • Publication number: 20140255962
    Abstract: Test elements are disclosed for detecting at least one analyte in a body fluid. The test element include at least one strip-shaped carrier element and at least one test field having at least one test chemistry for detecting the analyte. The test element has a symmetrical shape such that the test element may be inserted in one of at least two different correct measurement orientations into a test element receptacle of a testing device, which includes a detection device. In the different orientations, at least one analyte-induced change in the test chemistry of the test field is detectable. Test systems including the test elements and methods of detecting at least one analyte in the body fluid using the test elements also are disclosed.
    Type: Application
    Filed: May 22, 2014
    Publication date: September 11, 2014
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Frank Rueckert, Bruno Thoes
  • Publication number: 20140256056
    Abstract: An analytical system includes a laser disposed to direct light toward a microfluidic feature disposed in a feature layer of a multiple layer test cartridge, a sensor to receive reflections from capping layers disposed about the microfluidic feature in the feature layer, and a controller to determine a depth of the microfluidic feature as a function of the received reflections.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 11, 2014
    Applicant: Honeywell International Inc
    Inventor: Tzu-Yu Wang
  • Patent number: 8828329
    Abstract: An improved electronic diagnostic device for detecting the presence of an analyte in a fluid sample comprises a casing having a display, a test strip mounted in the casing, a processor mounted in the casing, and a first sensor mounted in the casing and operatively coupled to the processor. The processor is configured to receive a signal from the first sensor when the device is exposed to ambient light thereby causing the device to become activated. The device includes a light shield that exerts pressure across a width of the test strip to prevent fluid channeling along the length of the test strip. The processor is configured to present an early positive test result reading when a measured value exceeds a predetermined early reading threshold value at any time after a predetermined early testing time period.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: September 9, 2014
    Assignee: Church & Dwight, Co., Inc.
    Inventors: Andy Sturman, Benedict Zin, Albert Nazareth, Henry Bell
  • Patent number: 8828737
    Abstract: Methods for using focused light scattering techniques for the optical sensing of biological particles suspended in a liquid medium are disclosed. The optical sensing enables one to characterize particles size and/or distribution in a given sample. This, in turn, allows one to identify the biological particles, determine their relative particle density, detect particle shedding, and identify particle aggregation. The methods are also useful in screening and optimizing drug candidates, evaluating the efficacy and dosage levels of such drugs, and in personalized medicine applications.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: September 9, 2014
    Assignee: Invitrox, Inc.
    Inventor: Don Gabriel
  • Patent number: 8828734
    Abstract: Provided are a nitric oxide detection element capable of detecting NO gas contained in a mixed gas at a high speed even when the amount thereof is a super trace amount of ten and several parts per billion; and a process for producing the element. In a nitric oxide detection element having a substrate 12 and a sensing film 11 formed on a surface of the substrate, the sensing film is composed of nitric oxide sensing particles and a polymer adhesive. The nitric oxide sensing particles are produced by adsorbing a dye having a porphyrin skeleton and having, as a central metal, divalent cobalt onto surfaces of inorganic particles.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: September 9, 2014
    Assignees: Panasonic Healthcare Co., Ltd., National University Corporation Ehime University
    Inventors: Kouichi Hiranaka, Toyofumi Nagamatsu, Yoshihiko Sadaoka, Yoshiteru Itagaki
  • Patent number: 8828741
    Abstract: The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: September 9, 2014
    Assignee: Clondiag GmbH
    Inventors: Eugen Ermantraut, Ralf Bickel, Torsten Schulz, Thomas Ullrich
  • Patent number: 8828729
    Abstract: One embodiment is a SERS enhancing substrate which includes a porous substrate and a Raman enhancing material associated with a surface of the porous substrate. The Raman enhancing material may be a Raman enhancing metal or other Raman enhancing material. The Raman enhancing material may also be configured to improve binding of a taggant to the substrate. The substrate described above may be included in a sample vessel useful for the flow-through analysis of large sample volumes, or for the rapid analysis of very dilute samples. Other embodiments include methods and systems for detecting taggants with SERS and similar techniques.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: September 9, 2014
    Assignee: Cabot Corporation
    Inventors: Michael J. Natan, Marcelo Eduardo Piotti
  • Patent number: 8828666
    Abstract: The present invention provides a simple method which is capable of evaluating the binding activities of an antibody to both an antigen and an Fe receptor. Disclosed is a method of measuring the binding activities of an antibody to both an antigen or antigen epitope and an Fc receptor or a fragment thereof, comprising a step of mixing the antibody with the antigen or antigen epitope labeled with one member of a set of donor and acceptor capable of fluorescent resonance energy transfer and the Fc receptor or fragment thereof labeled with the other member of the set of donor and acceptor; a step of 10 irradiating the resultant mixture with light having a wavelength capable of exciting the donor; and a step of measuring the fluorescence level of the mixture. Also provided are a method of estimating the ADCC activity of an antibody, a method of controlling the quality of an antibody, a method of manufacturing an antibody, a method of screening for antibodies, and kits for use in these methods.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: September 9, 2014
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masashi Sakita, Takayuki Yoshimori
  • Patent number: 8828728
    Abstract: An aquatic environment monitoring system and method that includes correction for adverse conditions in the monitoring system involving the development of confidence levels for certain conditions in the monitoring system using stored information related to the aquatic environment and/or the monitoring system. Corrections to adverse conditions may be made by the environment monitoring system automatically by the monitoring system and manually via communications to a user of the system.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: September 9, 2014
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 8828730
    Abstract: Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support and a device dedicated to measure thrombin generation in a whole blood sample. Advantageously, the sample support comprises a separator medium allowing separation of whole blood into blood cells and blood plasma by means of (lateral) flow migration.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: September 9, 2014
    Assignee: Synapse B.V.
    Inventors: Hendrik Coenraad Hemker, Rafael Jesus Apitz-Castro, Sebastiaan Nijhuis
  • Patent number: 8828739
    Abstract: Rapid lateral flow immunoassays have an extensive history of use in both the clinical and home settings. These devices are used to test for a variety of analytes, such as drugs of abuse, hormones, proteins, urine or plasma components and the like. The present invention provides an improved procedural control that indicates to the test user that at least a portion of the applied sample has passed through the test result zone of the test strip, and optionally that the test is complete and the test results may be read.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 9, 2014
    Assignee: Alere Switzerland GmbH
    Inventors: Huiyan Guo, Min Wang, Tao Shang, Hui-Kang Chen, Fei Gao
  • Patent number: 8828678
    Abstract: A compound comprising the structure: (SIG)-(SI-MOD)m. is provided in which SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. When MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided are methods of determining whether a sample comprises an activator such as a nitroreductase, and methods of determining whether a mammalian cell is hypoxic using a compound of the formula (SIG)-(SI-MOD)m.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: September 9, 2014
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Maciej Szczepanik, Irina V. Lebedeva, Yuejun Xiang, Praveen Pande, Wayne Forrest Patton
  • Patent number: 8824770
    Abstract: Provided are methods for determining and analyzing photometric and morphometric features of small objects, such as cells to, for example, identify different cell states. In particularly, methods are provided for identifying apoptotic cells, and for distinguishing between cells undergoing apoptosis versus necrosis.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: September 2, 2014
    Assignee: Amnis Corporation
    Inventors: Thaddeus C. George, David A. Basiji, Brian E. Hall, William E. Ortyn, Michael J. Seo, Philip J. Morrissey, Cathleen A. Zimmerman
  • Patent number: 8823940
    Abstract: Methods and apparatuses for measuring a light absorbance are provided. The method measures light absorbance of at least one detection chamber of a microfluidic device, including the detection chamber and at least one reference chamber. The detection chamber may accommodate a test subject. The method includes detecting a plurality of reference transmitted light intensities for the at least one reference chamber and estimating a value between the plurality of reference transmitted light intensities through nonlinear approximation. The estimated value is then applied to light absorbance measurement of the detection chamber to reduce a light absorbance error of the detection chamber.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: September 2, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: Yeong Bae Yeo
  • Patent number: 8822227
    Abstract: A method for controlling actuation of label particles in a biosensor device, e.g., using frustrated total internal reflection, includes applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device. A feedback control of the actuation force is applied.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: September 2, 2014
    Assignee: Koninklijke Philips N.V.
    Inventor: Josephus Arnoldus Henricus Maria Kahlman
  • Patent number: 8822231
    Abstract: A method for the analysis of at least two analytes in a liquid sample, in which a substrate is provided wherein at least two different types of capturing molecules are immobilized on the substrate and wherein each type of capturing molecule has specific affinity for an analyte. The sample is contacted with capturing molecules, wherein for at least one analyte to be analyzed contact is induced between the capturing molecules and a labelled detection molecule with specific affinity for the analyte, and for at least one another analyte to be contact is induced between the capturing molecules and a labelled version of the analyte. A detectable signal is measured from the labelled detection molecule and the labelled analyte on the substrate, wherein the concentration of the labelled analyte is adapted to the concentration of the analyte in the sample.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: September 2, 2014
    Assignee: Johnson & Johnson AB
    Inventors: Jonas Melin, Christina Jönsson
  • Patent number: 8822230
    Abstract: In a chromatography quantitative measuring apparatus according to the present invention, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: September 2, 2014
    Assignee: Panasonic Healthcare Co., Ltd.
    Inventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
  • Publication number: 20140242715
    Abstract: Color-change compositions for detecting urine and feces volatiles include the following pH indicator dyes: m-Cresol Purple, Basic Fuchsin, Brilliant Blue G, Brilliant Blue R, Cresol Red and Thymol Blue. The compositions may be applied to various substrates. Such substrates may be used in the construction of a personal care absorbent article such as a diaper, training pant or incontinence garment.
    Type: Application
    Filed: February 28, 2013
    Publication date: August 28, 2014
    Inventors: Davis-Dang Hoang Nhan, Sridhar Ranganathan, JunMo Gil, Xuedong Song
  • Publication number: 20140242714
    Abstract: A filter element having filter media for filtering air passing therethrough and a detection strip attached thereto comprising a chemical compound that generates a chemical reaction with certain molecules that contact the detection strip.
    Type: Application
    Filed: February 22, 2013
    Publication date: August 28, 2014
    Applicant: BHA Altair, LLC
    Inventors: Bhalchandra Arun Desai, Huong Van Vu, Michael Adelbert Sullivan
  • Patent number: 8815233
    Abstract: A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and in particular, as a prognosticative of potential secretin, other neuropeptides, peptides, and digestive enzyme administration for persons having ADD, ADHD, Autism and other PDD related disorders.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: August 26, 2014
    Assignee: Curemark LLC
    Inventor: Joan M. Fallon
  • Patent number: 8815606
    Abstract: A thin-layer chromatography method for detection and identification of common military and peroxide explosives in samples includes the steps of provide a reverse-phase thin-layer chromatography plate; prepare the plate by marking spots on which to deposit the samples by touching the plate with a marker; spot one micro liter of a first standard onto one of the spots, spot one micro liter of a second standard onto another of the spots, and spot samples onto other of spots producing a spotted plate; add eluent to a developing chamber; add the spotted plate to the developing chamber; remove the spotted plate from the developing chamber producing a developed plate; place the developed plate in an ultraviolet light box; add a visualization agent to a dip tank; dip the developed plate in the dip tank and remove the developed plate quickly; and detect explosives by viewing said developed plate.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: August 26, 2014
    Assignee: Lawrence Livermore National Security, LLC.
    Inventors: Philip F. Pagoria, Alexander R. Mitchell, Richard E. Whipple, M. Leslie Carman
  • Patent number: 8815603
    Abstract: A chemochromic indicator is provided that includes a hypergolic fuel sensing chemochromic pigment that change from a first color to a second color in the presence of a hypergolic fuel. In a first embodiment, a chemochromic indicator is provided for detecting the presence of a hypergolic fuel such that the irreversible hypergolic fuel sensing chemochromic pigment includes potassium tetrachloroaurate (KAuCl4). There are several types of chemochromic indicators, for example, the article used to form the chemochromic indicators include, but are not limited to, wipe materials, silicone/TEFLON tape, manufactured parts, fabrics, extruded parts, and paints.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: August 26, 2014
    Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Luke B. Roberson, Robert W. DeVor, Janine E. Captain, Edgardo Santiago-Maldonado
  • Patent number: 8809066
    Abstract: An analyzing apparatus contains an image detection unit and an analysis unit. The image detection unit contains a view field area that covers at least a reaction area and a background area in a test piece. The reaction area exhibits a reaction color when exposed to a test substance in a specimen. The analysis unit detects the test substance based on the reaction color and determines, during detection of the test substance, whether a state of the background area falls within an acceptable range set for the test substance.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 19, 2014
    Assignee: Ushio Denki Kabushiki Kaisha
    Inventor: Shigeki Matsumoto
  • Patent number: 8808624
    Abstract: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement sample and a control portion performing a first classification of white blood cells in the measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of the fluorescent information and the two types of scattered light information.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: August 19, 2014
    Assignee: Sysmex Corporation
    Inventors: Hideaki Matsumoto, Kinya Uchihashi, Yuji Itose, Aya Konishi
  • Patent number: 8810804
    Abstract: Optical reader systems and methods with rapid microplate position detection capability are disclosed. The optical reader system includes a scanning optical system configured to scan select position-detecting features to accurately determine the microplate position within the optical reader system. The method includes measuring positions of the position-detecting features in order of their respective amounts of position tolerance, from smallest to largest. The position measurement is carried out for a number of position-detecting features sufficient to determine the microplate position with the optical reader system to within a select microplate position tolerance.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: August 19, 2014
    Assignee: Corning Incorporated
    Inventors: Ronald Charles Hollenbeck, Hak Chuah Sim, Cameron John Tovey, Cynthia L. Wida
  • Patent number: 8809063
    Abstract: A fluorescence based sensor (10) is disclosed and described. The sensor (10) can include nanofibril materials (12) fabricated from a linear carbazole oligomer and a fluorescence detector (14). The linear carbazole oligomer can have the formula (I) wherein n is 3 to 9, R are independently selected amine sidegroups, and at least one, but not all, R is a C1 to C14 alkyl. The carbazole-based fluorescence based sensors (10) can be particularly suitable for detection of explosives and volatile nitro compounds.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: August 19, 2014
    Assignee: University of Utah Research Foundation
    Inventors: Ling Zang, Yanke Che
  • Patent number: 8809061
    Abstract: A living body phantom according to the present invention, which is used as a testing sample in a prepared slide in estimating the performance of a microscope objective lens with the image of the testing sample in the prepared slide acquired by an imaging means via the microscope objective lens and with optical characteristics obtained from the image of the testing sample, includes a non-gel-like solution at least including: a solvent which at least includes water, a refractive index adjustment agent, and a scattering body or which at least includes a refractive index adjustment agent and a scattering body; and a thickener.
    Type: Grant
    Filed: March 5, 2012
    Date of Patent: August 19, 2014
    Assignee: Olympus Corporation
    Inventors: Asuka Mukai, Koji Yoshida
  • Patent number: 8801976
    Abstract: Photochromic dyes are disclosed. A photochromic dye can include a first photo-reactive group and a second photo-reactive group. A first photochromic reaction can be induced in the first photo-reactive group of the photochromic dye by radiation having a first wavelength, and a second photochromic reaction can be induced in the second photo-reactive group of the photochromic dye by radiation having a second wavelength.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: August 12, 2014
    Assignee: Korea University Research and Business Foundation
    Inventor: Dong Hoon Choi
  • Patent number: 8802443
    Abstract: A method for identifying gambiered Guangdong silk includes the steps of: detecting the surface state of fiber by microscope; detecting the pyrolysis fragments of fabrics by pyrolysis gas chromatography; determining the crude protein content in the fiber by Kjeldahl determination; and detecting the dye component of the fabrics by high performance liquid chromatography. The method of the present invention can accurately identify the true and fake, good and bad of the gambiered Guangdong silk, and then make an accurate evaluation on the gambiered Guangdong silk; and the present invention is simple, useful, environmental and has low cost.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: August 12, 2014
    Assignee: Shenzhen Liangzi Fashion Industrial Co., Ltd.
    Inventors: Zhihua Huang, Xueming Liu, Hongying Zhou, Yingying Wu
  • Patent number: 8802029
    Abstract: Systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: August 12, 2014
    Assignee: OPKO Diagnostics, LLC
    Inventors: David Steinmiller, Vincent Linder
  • Patent number: 8802442
    Abstract: The apparatus and method for detecting blood in urine or feces includes a photodetector configured to detect a transient light emitted in a toilet bowl by luminol and an oxidizer catalyzed by iron in the blood. The apparatus may include dispensers for the luminol, the oxidizer and a base. The apparatus may include a microprocessor and a network connection and may perform statistical analyzes, store data and alert the patient or a healthcare provider if blood is detected. The photodetector may be configured to detect light emitted in the toilet bowl by a fluorophore present in the water and excited by the transient light from the luminol and oxidizer.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: August 12, 2014
    Inventors: Eric B. Wheeldon, Robert J. Barsotti
  • Publication number: 20140220700
    Abstract: A capillary absorption spectrometer and process are described that provide highly sensitive and accurate stable absorption measurements of analytes in a sample gas that may include isotopologues of carbon and oxygen obtained from gas and biological samples. It further provides isotopic images of microbial communities that allow tracking of nutrients at the single cell level. It further targets naturally occurring variations in carbon and oxygen isotopes that avoids need for expensive isotopically labeled mixtures which allows study of samples taken from the field without modification. The method also permits sampling in vivo permitting real-time ambient studies of microbial communities.
    Type: Application
    Filed: February 1, 2013
    Publication date: August 7, 2014
    Inventors: M. Lizabeth Alexander, James F. Kelly, Robert L. Sams, James J. Moran, Matthew K. Newburn
  • Patent number: 8796040
    Abstract: A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity of the fluorescence of the labelled target biomolecule, thereby quantitatively determining the target biomolecule.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 5, 2014
    Assignees: The Furukawa Electric Co., Ltd., The University of Tokushima
    Inventors: Hideki Aizawa, Michio Ohkubo, Michihiro Nakamura, Hirokazu Miyoshi
  • Patent number: 8796012
    Abstract: A technique for high sensitivity evanescent field molecular sensing employs a detection scheme that simultaneously couples a polarized beam to a single mode of a waveguide, and couples the polarized beam out of the waveguide to specularly reflect the beam by the same grating. Strong interaction with the single (preferably TM) mode is provided by using a silicon on insulator (SOI) wafer having a waveguide thickness chosen between 10-400 nm so that the majority of the mode field strength spans the evanescent field. Well known, robust techniques for producing a grating on the waveguide are provided. Interrogation from a backside of the SOI wafer is taught.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 5, 2014
    Assignee: National Research Council of Canada
    Inventors: Bill Sinclair, Jens Schmid, Philip Waldron, Dan-Xia Xu, Adam Densmore, Trevor Mischki, Greg Lopinski, Jean Lapointe, Daniel Poitras, Siegfried Janz
  • Patent number: 8795523
    Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: August 5, 2014
    Assignee: Intel Corporation
    Inventors: Xing Su, David J. Liu, Kai Wu, Kenneth B. Swartz, Mineo Yamakawa
  • Patent number: 8795595
    Abstract: A sensing apparatus may include a substrate having a first side for a sensing element and a second side for electronics, the substrate may have a at least one via from the first side of the substrate to the second side of the substrate, the at least one via may be hermetically sealed with an optically transmissive material.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: August 5, 2014
    Assignee: Medtronic Minimed, Inc.
    Inventor: Rajiv Shah
  • Patent number: 8796033
    Abstract: A method for analyzing a minute quantity of a material included in a different material is performed in short extraction treatment without taking a long time and the minute content is rapidly analyzed. The method of analyzing a minute content includes mounting on a sample table a sample piece of a material having a minute content of a different material to be analyzed; dropping onto the sample table a solvent for extracting the minute content from the sample piece, so that the solvent is disposed between the sample table and the sample piece; maintaining at room temperature the solvent between the sample table and the sample piece, and, with the solvent maintained between the sample table and the sample piece, extracting the material of the minute content from the sample piece; and analyzing the content extracted from the sample piece.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: August 5, 2014
    Assignee: Mitsubishi Denki Kabushiki Kaisha
    Inventors: Jiro Naka, Hiroshi Kurokawa, Junji Kobayashi, Satoru Toyama, Noriko Hirano, Eiji Hara
  • Patent number: 8790930
    Abstract: A chemical indicator having a particulate inorganic substrate, and at least one reactive dye or ink coated on and/or impregnated within the particulate inorganic substrate. Coating and/or impregnating at least one reactive dye or ink on or within a particulate inorganic substrate improves the storage stability and/or thermal stability of the at least one reactive dye or ink, which typically includes relatively unstable compounds. This allows the present indicators to be incorporated into thermoplastic polymer materials and processed conventionally while maintaining the efficacy and stability of the new indicators. The indicators provide simple, reliable, and cost effective detection means for detecting analytes such as ammonia, carbon dioxide, and oxygen, and may find use in applications such as food packaging and medical applications.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 29, 2014
    Assignee: University of Strathclyde
    Inventors: Andrew Mills, Pauline Grosshans, Graham Skinner