With Reagent In Absorbent Or Bibulous Substrate Patents (Class 436/169)
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Patent number: 8916110Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.Type: GrantFiled: July 5, 2011Date of Patent: December 23, 2014Assignee: Boehringer Ingelheim Microparts GmbHInventors: Tobias Rodenfels, Gert Blankenstein
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Patent number: 8911681Abstract: A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous-based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.Type: GrantFiled: September 12, 2011Date of Patent: December 16, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Xuedong Song, Karen Meloy Goeders, Ning Wei
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Patent number: 8900881Abstract: The present invention relates to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the test membrane and a porous downstream membrane in fluid connection with the test membrane, wherein the test membrane contains two bands having deposited on there high and low concentrations of different calibrator agents and a test band capable of reacting with conjugated analyte complexes giving rise to a measurable signal.Type: GrantFiled: September 12, 2011Date of Patent: December 2, 2014Inventor: Jin Po Lee
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Patent number: 8901366Abstract: In accordance with one embodiment of the present disclosure, a method for quantitatively or semi-quantitatively determining the volume of a test sample of urine is provided. The method includes contacting the test sample with a fluidic medium of a lateral flow device having a volume indicator disposed thereon and determining the volume of urine in the test sample based on the distance traveled by the volume indicator along the fluidic medium, the distance traveled by the volume indicator corresponding to the volume of urine in the test sample.Type: GrantFiled: December 14, 2007Date of Patent: December 2, 2014Assignee: Kimberly Clark Worldwide, Inc.Inventors: Xuedong Song, RameshBabu Boga, Ning Wei
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Publication number: 20140329235Abstract: A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the channel. The porous substrate fills a cross section of the channel, and the cross-sectional area of the channel at the porous substrate is greater than the cross-sectional area at the nozzle.Type: ApplicationFiled: July 16, 2014Publication date: November 6, 2014Inventors: Debapriya Mazumdar, David G. Kellner
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Patent number: 8877515Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.Type: GrantFiled: July 7, 2011Date of Patent: November 4, 2014Assignee: FUJIFILM CorporationInventors: Hiroyuki Chiku, Junichi Katada, Hideyuki Karaki, Hiroki Terada
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Publication number: 20140323322Abstract: A chemical sensor comprising: a hydrogel layer, comprising one or more molecular recognition agents and a 2DPC self-assembling array; and a mirror layer. A method for analyzing a sample or bodily fluid, comprising: obtaining a sample or bodily fluid; placing an amount of the sample or bodily fluid onto a chemical sensor, comprising: a hydrogel layer, comprising a molecular recognition agent and a 2DPC self-assembling array; a tethering hydrogel layer; a mirror layer; and a membrane filter layer, allowing the bodily fluid to interact with the hydrogel layer; and allowing ambient or artificial light to pass through the hydrogel layer onto the mirror layer and observing a change in diffraction versus a control.Type: ApplicationFiled: October 4, 2012Publication date: October 30, 2014Inventor: Sanford A. Asher
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Patent number: 8865089Abstract: Described here are systems, devices, cartridges, methods, and kits for detecting or quantifying at least two different analytes using at least two different techniques, in a single sample. The cartridges typically comprise at least two test sites and the location of at least one test site is not dependent on a corresponding measurement device. The systems generally comprise a device, memory, and a processing module. The device comprises a light source, an array detector, and a port configured to accept at least a portion of a cartridge. The processing module is configured to perform an image analysis of the cartridge. The methods comprise the steps of acquiring calibration information, acquiring an image of the cartridge, performing an image analysis, and cycling through specific detection or quantification techniques corresponding to the techniques required by the test sites. Computer readable media are also described.Type: GrantFiled: December 14, 2010Date of Patent: October 21, 2014Assignee: Polymer Technology Systems, Inc.Inventors: Joel M. Blatt, Carole R. Stivers
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Patent number: 8865454Abstract: The invention relates to a flow through system for quantifying a target component in a liquid. The flow through system comprises a flow-through device comprising a flow path comprising a marker section, a capture section downstream to said marker section, and at least two quantification sections. The marker section comprises a non-immobilized marker. The capture section comprises a capture zone with an immobilized capture agent, and the at least two quantification sections comprise a pre-capture quantification section placed downstream to the marker section and up stream to the capture section, and a post-capture quantification section placed downstream to the capture section. The system further comprises a quantification unit for each of said quantification sections. The quantification unit(s) being arranged to quantify marker containing components and/or particles passing through said respective quantification sections.Type: GrantFiled: March 17, 2008Date of Patent: October 21, 2014Assignee: Scandinavian Micro Biodevices APSInventor: Jacques Jonsmann
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Patent number: 8846319Abstract: The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the devices are also described.Type: GrantFiled: December 3, 2009Date of Patent: September 30, 2014Assignee: Abaxis, Inc.Inventors: Rajesh K. Mehra, Kenneth P. Aron
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Patent number: 8841131Abstract: A cholesterol-level measuring apparatus including a portable body having a cholesterol level detecting means for identifying a cholesterol level in a blood sample, and a display screen communicatively coupled to the cholesterol level detecting means for illustrating a learned cholesterol level in the blood sample. Notably, the cholesterol level detecting means includes a disposable test strip having a color-changing reactive reagent that changes color in response to the learned cholesterol level in the blood sample.Type: GrantFiled: October 9, 2012Date of Patent: September 23, 2014Inventor: Ifeanyi Nzeribe
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Patent number: 8835182Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.Type: GrantFiled: January 24, 2013Date of Patent: September 16, 2014Assignee: FUJIFILM CorporationInventors: Junichi Katada, Hideyuki Karaki, Takayoshi Oyamada
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Patent number: 8828730Abstract: Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support and a device dedicated to measure thrombin generation in a whole blood sample. Advantageously, the sample support comprises a separator medium allowing separation of whole blood into blood cells and blood plasma by means of (lateral) flow migration.Type: GrantFiled: August 5, 2009Date of Patent: September 9, 2014Assignee: Synapse B.V.Inventors: Hendrik Coenraad Hemker, Rafael Jesus Apitz-Castro, Sebastiaan Nijhuis
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Patent number: 8828739Abstract: Rapid lateral flow immunoassays have an extensive history of use in both the clinical and home settings. These devices are used to test for a variety of analytes, such as drugs of abuse, hormones, proteins, urine or plasma components and the like. The present invention provides an improved procedural control that indicates to the test user that at least a portion of the applied sample has passed through the test result zone of the test strip, and optionally that the test is complete and the test results may be read.Type: GrantFiled: May 25, 2012Date of Patent: September 9, 2014Assignee: Alere Switzerland GmbHInventors: Huiyan Guo, Min Wang, Tao Shang, Hui-Kang Chen, Fei Gao
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Patent number: 8822151Abstract: Point-of-care binding assays include at least one target nucleic acid binding in a multiplex structure with at least one sequence in a partner nucleic acid associated with a label, due to complementary base pairings between at least one sequence in the target nucleic acid and at least one sequence in the partner nucleic acid. The assays overcome the inherent deficiencies of antibody-protein antigen assays. In a preferred embodiment, color tagged nucleic acid sequences are used to bind a complementary target nucleic acid. The tagged nucleic acid sequences are preferably made from deoxyribonucleotides, ribonucleotides, or peptide nucleotides.Type: GrantFiled: June 25, 2012Date of Patent: September 2, 2014Assignee: Rapid Pathogen Screening, Inc.Inventors: Robert P. Sambursky, Uma Mahesh Babu, Robert W. VanDine
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Patent number: 8821810Abstract: The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.Type: GrantFiled: February 3, 2011Date of Patent: September 2, 2014Assignee: President and Fellows of Harvard CollegeInventors: George M. Whitesides, Katherine A. Mirica, Andres W. Martinez, Chao-Min Cheng, Scott T. Phillips, Monica MascareƱas, Xinyu Liu, Xiujun Li
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Publication number: 20140242713Abstract: Porous sol-gel material essentially consisting of units of one or more first polyalkoxysilanes chosen from the following compounds: (chloromethyl)triethoxysilane; 1,3-dimethyltetramethoxydisiloxane; ethyltrimethoxysilane; triethoxy(ethyl)silane; triethoxymethylsilane; triethoxy(vinyl)silane; trimethoxymethylsilane; trimethoxy(vinyl)silane; tetraethoxysilane or tetramethoxysilane (TMOS) and of units of one or more second polyalkoxysilanes chosen from the following compounds: (N-(3-(trimethoxysilyl)propyl)ethylenediamine; 3-aminopropyltriethoxysilane (APTES) and 3-aminopropyltrimethoxysilane, in a first polyalkoxysilane/second polyalkoxysilane molar ratio of 1/0.01 to 1/1, optionally comprising a probe molecule, method of preparation and applications in the trapping of monocyclic aromatic hydrocarbons and other pollutants or in their detection.Type: ApplicationFiled: May 6, 2014Publication date: August 28, 2014Applicants: CEA - COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQU EInventors: Sabine Crunaire, Thu-Hoa Tran-Thi
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Patent number: 8815606Abstract: A thin-layer chromatography method for detection and identification of common military and peroxide explosives in samples includes the steps of provide a reverse-phase thin-layer chromatography plate; prepare the plate by marking spots on which to deposit the samples by touching the plate with a marker; spot one micro liter of a first standard onto one of the spots, spot one micro liter of a second standard onto another of the spots, and spot samples onto other of spots producing a spotted plate; add eluent to a developing chamber; add the spotted plate to the developing chamber; remove the spotted plate from the developing chamber producing a developed plate; place the developed plate in an ultraviolet light box; add a visualization agent to a dip tank; dip the developed plate in the dip tank and remove the developed plate quickly; and detect explosives by viewing said developed plate.Type: GrantFiled: April 21, 2008Date of Patent: August 26, 2014Assignee: Lawrence Livermore National Security, LLC.Inventors: Philip F. Pagoria, Alexander R. Mitchell, Richard E. Whipple, M. Leslie Carman
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Patent number: 8815609Abstract: A lateral flow device includes a sample compressor and a test strip comprising a diverting zone. The diverting zone, which may include a barrier and/or a gap or ditch, stops or impedes flow. Flow is reinitiated and diverted into an alternate plane by compression of a sample compressor. Flow returns to the original, lateral plane, at the end of the diverting zone.Type: GrantFiled: March 7, 2013Date of Patent: August 26, 2014Assignee: Rapid Pathogen Screening, Inc.Inventors: Uma Mahesh Babu, Robert P. Sambursky, Peter Condon, Robert W. VanDine
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Patent number: 8815156Abstract: A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the channel. The porous substrate fills a cross section of the channel, and the cross-sectional area of the channel at the porous substrate is greater than the cross-sectional area at the nozzle.Type: GrantFiled: July 19, 2010Date of Patent: August 26, 2014Assignee: ANDalyze, Inc.Inventors: Debapriya Mazumdar, David G. Kellner
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Patent number: 8808639Abstract: The present invention relates to a test strip for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen. More particularly, the present invention relates to an improved test strip and scale for determining and/or quantifying a property of a sample, such as the concentration of an analyte, the pH, the viscosity, or the specific gravity of a fluid specimen.Type: GrantFiled: March 20, 2013Date of Patent: August 19, 2014Assignee: Akers BioSciences, Inc.Inventors: Susan Andrelczyk, Leonard Schluter
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Patent number: 8784689Abstract: The present invention relates to a color-changing composition and a multiple-component material including a substrate and a printed layer on the substrate. The printed layer includes a color-changing composition to indicate a change in condition, such as a change in wetness. The color-changing composition includes a matrix-forming component, a leuco dye, a Lewis Acid, a neutral surfactant and an organic solvent.Type: GrantFiled: July 8, 2011Date of Patent: July 22, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Xuedong Song
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Patent number: 8778698Abstract: In a chromatography quantitative measuring apparatus, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.Type: GrantFiled: December 18, 2009Date of Patent: July 15, 2014Assignee: Panasonic Healthcare Co., Ltd.Inventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
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Patent number: 8778276Abstract: The present invention provides devices, in particular lateral flow devices, for detecting a target analyte on a surface, in which the elements of collection and detection are integrated. The present invention also provides methods of use thereof.Type: GrantFiled: June 18, 2009Date of Patent: July 15, 2014Assignee: The Secretary of State for DefenceInventor: Peter John White
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Patent number: 8772045Abstract: The present method and system may be used for detecting the presence of explosive elements. A sample element may be used to swipe an object for a test sample. The sample element may be positioned in a sample holder of a testing device having a heater. The heater may be programmed to heat the sample element and sample in a controlled manner through two temperature increases from approximately 35 degrees to 165 degrees centigrade in approximately 20 seconds. Prior to each temperature increase a first and second reagent fluid is applied to the sample holder, and during the temperature rise the sample holder is observed for the presence of various explosive elements by detecting colors as compared to a color chart. The color observations may be based on time and temperature variations using a testing device.Type: GrantFiled: May 23, 2011Date of Patent: July 8, 2014Inventor: Jeffrey S. Haas
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Patent number: 8747773Abstract: Embodiments of the invention relate to portable detection apparatus, comprising one or more detector regions adapted to visually indicate the presence or amount of an analyte in a beverage. The detection apparatus is shaped substantially the same as a consumer product.Type: GrantFiled: August 11, 2011Date of Patent: June 10, 2014Inventor: Maryse Thomas
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Patent number: 8742198Abstract: A dehydration sensor having a stable, printable, buffered-ink composition that enables one to miniaturize the detection zone and permits both buffer and indicator dye to be applied in the same area of a detection zone, without need for a conventional, large buffer pad region. The ink composition includes a weak polymeric base as its primary buffering agent.Type: GrantFiled: December 1, 2010Date of Patent: June 3, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Ning Wei, Xuedong Song, Ronnie L. Phillips
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Patent number: 8741658Abstract: A method and devices analyze for the presence of cyanide in samples using colorimetric analysis of samples after contacting with cobinamide or monocyanocohinapmide.Type: GrantFiled: March 15, 2011Date of Patent: June 3, 2014Assignees: The Regents of the University of California, Board of Regents, The University of Texas SystemInventors: Gerry Boss, Vijay Sharma, Matthew Brenner, Purnendu K. Dasgupta, William Curt Blackledge
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Patent number: 8734341Abstract: A hydration sensor or sensing element configured to measure the hydration level of a user is disclosed. The sensing element can include a water-permeable material positioned in between two water-impermeable material. The sensing element can be coupled to a bottle of fluid, or a carrier with a timer. The sensing element can be incorporated into a handheld device. The sensing element can be a disposable element, an element applicable for more than one-time use, or a re-usable element. The sensing element or sensor can be calibrated for a specific user or a group of users. One or more additional sensors that do not measure hydration level of the user can be coupled to a hydration sensing element to determine the amount of fluid consumption for the user in different conditions.Type: GrantFiled: November 2, 2006Date of Patent: May 27, 2014Assignee: IpVenture, Inc.Inventors: Thomas A. Howell, Angeline Hadiwidjaja, Peter P. Tong, C. Douglass Thomas
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Patent number: 8721990Abstract: Disclosed is an assay device for the determination of the presence and/or extent if an analyte in a liquid sample over an extended concentration range comprising a first assay and a second assay, wherein the first assay for an analyte comprises a first flow-path having a sole detection zone capable of immobilizing a labelled binding reagent and the second assay for said analyte comprises a second flow-path having a sole detection zone capable of immobilizing a labelled binding reagent, wherein the presence of labelled binding reagent at the detection zones provides an indication of the presence and/or extent of analyte in said liquid sample.Type: GrantFiled: April 9, 2008Date of Patent: May 13, 2014Assignee: Alere Switzerland GmbHInventors: Balbir Raj, Saji Eapen, Ezra Linley
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Patent number: 8722424Abstract: In a chromatography quantitative measuring apparatus, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.Type: GrantFiled: December 18, 2009Date of Patent: May 13, 2014Assignee: Panasonic CorporationInventors: Koji Miyoshi, Masahiro Aga, Kaoru Shigematsu
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Patent number: 8720775Abstract: An access control system for sensing exposure to items of interest for a person associated with a unique identifier of a fare card or ticket is disclosed. The access control system includes the unique identifier, an exposure detector and a processor. The unique identifier associated with the person that is flagged when exposure is detected. The exposure detector detects exposure to items of interest by the person. The processor is coupled to the exposure detector. The message is communicated away from the processor to a remote location when the unique identifier is flagged.Type: GrantFiled: March 23, 2011Date of Patent: May 13, 2014Assignee: Cubic CorporationInventors: Jon D. Macklin, Walter C. Bonneau, Jr., Bruce D. Roberts
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Patent number: 8715590Abstract: A diagnostic test device comprising at least one membrane disposed in any of one, two, and three dimensions; at least one test sample fluid input port that receives and transfers at least one test sample fluid and onto the at least one membrane; at least one contiguous fluid flow manifold within the at least one membrane to multiplex or distribute the at least one test sample fluid; at least one contiguous fluid flow channel that operatively connects the at least one membrane to the at least one contiguous fluid flow manifold; at least one analyte assay test zone disposed within the at least one contiguous fluid flow channel; and at least one chemical capturing reagent disposed within the at least one analyte assay test zone, wherein multiple analyte assay test results are simultaneously obtained and in parallel in the diagnostic test device.Type: GrantFiled: August 14, 2009Date of Patent: May 6, 2014Assignee: Prognosys LLCInventors: Marc H. Cohen, Kenneth A. Gabriel, Lawrence J. Loomis
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Patent number: 8716028Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.Type: GrantFiled: December 31, 2012Date of Patent: May 6, 2014Assignee: Nalco CompanyInventors: Amy Tseng, Brian V. Jenkins, Robert M. Mack
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Patent number: 8709826Abstract: The invention relates to a device for determining an analyte in a liquid sample. The inventive device consists of: a capillary action means, involving lateral migration, defining a reference capillary action direction and comprising a liquid sample deposit area and an analytedetection area which is disposed downstream of the deposit area; a first analytespecific binding reagent which is conjugated to a visible and/or measurable marker and which is free to migrate when wet by means of capillary action in the abovementioned capillary actions means along the reference direction; and a second analytespecific binding reagent which is immobilized in the detection area. The invention is characterized in that the detection area comprises the analyte or an analogue of the analyte, which is immobilized and disposed at a distance from the second specific binding reagent.Type: GrantFiled: August 23, 2006Date of Patent: April 29, 2014Assignee: VedalabInventor: Raphael Donati
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Patent number: 8704035Abstract: A dehydration sensor having a stable, printable, buffered-ink composition that enables one to miniaturize the detection zone and permits both buffer and indicator dye to be applied in the same area of a detection zone, without need for a conventional, large buffer pad region. The ink composition includes a weak polymeric base as its primary buffering agent.Type: GrantFiled: December 1, 2010Date of Patent: April 22, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Ning Wei, Xuedong Song, Ronnie L. Phillips
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Patent number: 8703504Abstract: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.Type: GrantFiled: September 4, 2013Date of Patent: April 22, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Xuedong Song
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Patent number: 8685745Abstract: A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.Type: GrantFiled: October 26, 2011Date of Patent: April 1, 2014Assignee: Polestar Technologies, Inc.Inventor: James A. Kane
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Patent number: 8685743Abstract: A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.Type: GrantFiled: April 30, 2010Date of Patent: April 1, 2014Assignee: The Regents of the University of CaliforniaInventors: Xiang Zhang, Jonathan A. Ellman, Fanqing Frank Chen, Kai-Hang Su, Qi-Huo Wei, Cheng Sun
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Patent number: 8685744Abstract: A mobile water analyzing system for determining an analyte in a water sample includes a basic unit and a test element configured to be inserted into the basic unit. The test element includes a sample line with an inlet opening configured to receive the water sample, a measuring section forming a measuring track and configured to allow the determination of an analyte, a pump opening, and a key reagent disposed inside the sample line. The basic unit includes a test element receptacle configured to hold the inserted test element, an analyzer with an analyzer measuring track formed by the measuring section, and a pump actuator cooperatively connected with the pump opening.Type: GrantFiled: September 28, 2009Date of Patent: April 1, 2014Assignee: Hach Lange GmbHInventors: Ulrich Lundgreen, Aria Farjam, Rolf Uthemann, Andreas Mitreiter, Isabel Huenig, Markus Lenhard, Rainer Froemel, Hans-Joachim Kumpch
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Publication number: 20140088532Abstract: A liquid-activated formulation is provided, comprising a liquid-activated colorant, a hydrochromic ionic compound, an opacifier, a binding matrix, and a surfactant.Type: ApplicationFiled: September 26, 2013Publication date: March 27, 2014Applicant: The Procter & Gamble CompanyInventors: Laveeta Joseph, Thomas James Klofta, Sebastian V. Kanakkanatt, Santosh B. Kanakkanatt, William Winfield Cheeseman, JR.
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Patent number: 8679853Abstract: A test strip or biosensor comprising a base substrate on which an electrode system is formed. One or more laminate layers overlie the base substrate to form a sample-receiving chamber in which a reagent is deposited. An opening is provided from the sample-receiving chamber to the exterior of the biosensor. The layers and the base substrate are laser welded to secure the biosensor. One of the layer and base substrate is light transmissive to allow laser welding at the interface therebetween. The biosensor may be formed from a series of continuous webs that are subsequently sliced to form individual biosensors.Type: GrantFiled: July 3, 2007Date of Patent: March 25, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Raghbir S. Bhullar, Ali Razban
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Patent number: 8673651Abstract: A package for holding and disguising a chromatographic test of food and drink is formed in the shape of a drinking straw or stirrer. The package encloses test patches which are sensitive to particular drugs and produce a color change upon contact with the drug. The package has a view port or slit to observe the condition of the test strip upon contact with food and drink.Type: GrantFiled: November 3, 2005Date of Patent: March 18, 2014Assignee: GelTech Solutions, Inc.Inventors: Peter Cordani, Anne Cordani
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Patent number: 8669115Abstract: An explosion tester system comprising a body, a lateral flow membrane swab unit adapted to be removeably connected to the body, a first explosives detecting reagent, a first reagent holder and dispenser operatively connected to the body, the first reagent holder and dispenser containing the first explosives detecting reagent and positioned to deliver the first explosives detecting reagent to the lateral flow membrane swab unit when the lateral flow membrane swab unit is connected to the body, a second explosives detecting reagent, and a second reagent holder and dispenser operatively connected to the body, the second reagent holder and dispenser containing the second explosives detecting reagent and positioned to deliver the second explosives detecting reagent to the lateral flow membrane swab unit when the lateral flow membrane swab unit is connected to the body.Type: GrantFiled: May 21, 2010Date of Patent: March 11, 2014Assignee: Lawrence Livermore National Security, LLC.Inventors: Philip F. Pagoria, Richard E. Whipple, Peter J. Nunes, Joel Del Eckels, John G. Reynolds, Robin R. Miles, Marina L. Chiarappa-Zucca
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Patent number: 8663563Abstract: A reflective diffractometric hydrogel sensor includes an upper layer, including a microfluidic chamber formed from a substantially transparent material and configured to contain a solution, a reflective diffraction grating positioned within the microfluidic chamber, the diffraction grating including a plurality of hydrogel strips configured to change in dimension in response to a stimulus, each hydrogel strip having a top surface coated with a reflective material and a bottom surface in contact with the upper layer substrate, and a reflective surface below the reflective diffraction grating wherein when a coherent light is incident upon and reflected from the upper layer at an angle substantially normal to the upper layer an interference diffraction pattern results, including a first diffraction mode, a light intensity of which indicates the relative distance between the top surfaces of the plurality of hydrogel strips and the reflective surface.Type: GrantFiled: December 5, 2011Date of Patent: March 4, 2014Assignees: Purdue Research Foundation, Board of Regents, The University of Texas SystemInventors: Cagri Savran, Chun-Li Chang, Zhenwen Ding, Babak Ziaie, Andrew Ellington, Venkata Naga Lakshmi Rekha Patchigolla
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Patent number: 8647883Abstract: A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.Type: GrantFiled: September 13, 2010Date of Patent: February 11, 2014Assignee: General Electric CompanyInventors: Radislav A. Potyrailo, Timothy M. Sivavec, Caibin Xiao, Theodore J. Cecconie, Lamyaa Hassib, Andrew M. Leach, David B. Engel
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Publication number: 20140030816Abstract: The invention is directed to a swipe with at least one ionization reagent associated with the swipe for detecting target analytes and methods of detecting the target analyte molecules that can indicate the presence of, for example, explosives, narcotics, chemical warfare agents, biological warfare agents, or toxins. The swipe can be used to transfer molecules from a surface to the swipe for further analysis. In particular, the swipes can include an ionization reagent that is preferably a low volatility compound and capable of forming ionization reagent-analyte complexes with target analytes. The swipe can also include multiple ionization reagents with different volatilities such that they are released sequentially during a thermal ramp-up. Alternatively, the swipe can have multiple ionization reagents associated with spatially separated portions of the swipe such that they can be releasable sequentially to detect multiple target analytes.Type: ApplicationFiled: March 15, 2013Publication date: January 30, 2014Applicant: Massachusetts Institute of TechnologyInventor: Massachusetts Institue of Technology
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Patent number: 8632730Abstract: In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.Type: GrantFiled: November 22, 2005Date of Patent: January 21, 2014Assignee: Alverix, Inc.Inventors: John F. Petrilla, Daniel B. Roitman
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Patent number: 8623290Abstract: The present invention relates to a color-changing material and to a multiple-component material that includes a color-changing composition. The color-changing materials and color-changing compositions are capable of changing color in order to indicate a change in condition, such as a change in pH. The color-changing materials and color-changing compositions include a hydrogel-forming composition, a charged colorant and a pH adjuster. The hydrogel-forming composition includes at least one charged species.Type: GrantFiled: September 4, 2012Date of Patent: January 7, 2014Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Xuedong Song, Kaiyuan Yang, Stephanie M. Martin, Maia Bageant
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Patent number: 8617486Abstract: An analytical device for performing an assay to determine the presence or approximate quantity of at least one analyte in a liquid sample is described. The device is manufactured to include an integrated desiccant within at least a test strip of the device. Addition of an integrated desiccant within the device improves signal to noise ratio, eases the manufacturing process, and saves in cost of production of the device.Type: GrantFiled: May 6, 2013Date of Patent: December 31, 2013Assignee: Quidel CorporationInventors: Kevin J. Kirby, Sarah Dennison