Liquid Patents (Class 494/27)
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Patent number: 7410456Abstract: In a centrifugal separator the liquid separation aid attracts/binds contaminating particles in oil supplied to a separation chamber. Purified oil is discharged through a central light phase outlet of the separation chamber, the liquid separation aid and separated particles are discharged through a heavy phase outlet. Purification is carried through using a starting liquid, supplied to the separation chamber to form a layer that creates a liquid seal in the centrifugal rotor, covering said heavy phase outlet. Contaminated oil and liquid separation aid are supplied to the separation chamber. While purified oil leaves the separation chamber through the light phase outlet, at starting liquid and liquid separation aid together with particles are discharged through the heavy phase outlet.Type: GrantFiled: December 10, 2003Date of Patent: August 12, 2008Assignee: Alfa Laval Corporate ABInventor: Claes Wase
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Patent number: 7314441Abstract: A method for separating particulate matter from a fluid includes feeding a fluid containing a particulate matter into a chamber of a vessel through an inlet, the chamber being at least partially bounded by a peripheral wall and the chamber also communicating with a first outlet and a second outlet. The vessel is rotated such that at least a portion of the particulate matter settles out of the fluid against at least a portion of the peripheral wall. At least a portion of the particulate matter settled against the peripheral is subsequently disturbed so that at least a portion of the particulate matter is resuspend within the fluid. The method further includes removing at least a portion of the fluid having the resuspended particulate matter therein through the first outlet and removing through the second outlet the fluid from which the particulate material has settled out.Type: GrantFiled: May 30, 2006Date of Patent: January 1, 2008Assignee: Econova, Inc.Inventor: Kevin E. Collier
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Patent number: 7217234Abstract: The present disclosure includes a method of controlling a centrifuge for the centrifugal production of a milk product. The steps include taking a milk sample at an outlet of the centrifuge from a liquid phase, adding a substance to the milk sample that increases light transmittance of the milk sample, determining the light transmittance of the milk sample by transilluminating the milk sample using a light source and measuring light intensity via a photo cell, determining the fat content from a measurement of the light transmittance, and controlling the centrifuge as a function of the determination of the fat content. The present disclosure also includes a system for controlling the centrifuge.Type: GrantFiled: July 2, 2002Date of Patent: May 15, 2007Assignee: Westfalia Separator AGBInventor: Karl-Heinz Zettier
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Patent number: 7115205Abstract: A system for automatically collecting and separating whole blood into its components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.Type: GrantFiled: July 14, 2004Date of Patent: October 3, 2006Assignee: Mission Medical, Inc.Inventors: Thomas C. Robinson, Thomas P. Robinson, Richard D'Elia, Thomas Sahines, Paul Eibe
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Patent number: 7056273Abstract: A solid bowl screw centrifuge includes a centrifuging chamber and a rotatable drum having a horizontal axis of rotation. The rotatable drum surrounds the centrifuging chamber. Also included is a rotatable screw arranged in the rotatable drum, at least one solids discharge, at least one liquid discharge duct and a peeling disk via which liquids are discharged through the liquid discharge duct. Further included is a blocking chamber connected to an output side of the peeling disk.Type: GrantFiled: May 27, 2003Date of Patent: June 6, 2006Assignee: Westfalia Separator AGInventors: Wilhelm Ostkamp, Franz Kramer, Wolf-Dietrich Herberg
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Patent number: 6852074Abstract: A method and apparatus for selectively expressing one or more selected fluid materials out of a fluid container, including a centrifuge rotor having a round centrifuge chamber of selected volume, a round expandable enclosure disposed within the centrifuge chamber having a rotation axis coincident with the central rotation axis and a flexible wall, a pump for controllably pumping a selected volume of expresser fluid into and out of the expandable enclosure wherein the fluid container is receivable within the centrifuge chamber, and a retaining mechanism for holding the fluid container within the centrifuge chamber in a coaxial position. The flexible wall of the fluid container is in contact with the flexible wall of the expandable enclosure.Type: GrantFiled: May 20, 1998Date of Patent: February 8, 2005Assignee: ZymeQuest, Inc.Inventors: Glen Jorgenson, Donald Barry, Bruce H. Edwards, John P. O'Brien, Victor Sacco, Jr.
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Patent number: 6835171Abstract: A centrifuge is provided for the separation and/or treatment of cells in a substantially annular or partially annular separation bag connected by at least one tube to at least one secondary bag. The centrifuge comprises a rotor bowl connected at the upper end of a rotor shaft. The rotor shaft includes a hollow upper portion defining a central compartment for receiving the at least one secondary bag. The rotor bowl includes a separation compartment for receiving the separation bag and an expandable hydraulic chamber located within the separation compartment for selectively squeezing the separation bag within the separation compartment so as to transfer a separated component from the separation bag into a secondary bag in the central compartment. A hydraulic system is connected to the hydraulic chamber by a duct extending through the rotor shaft for pumping a hydraulic liquid to and from the hydraulic chamber.Type: GrantFiled: January 16, 2004Date of Patent: December 28, 2004Assignee: Gambro IncInventors: Peter Unger, Eric Westberg
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Patent number: 6827863Abstract: A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.Type: GrantFiled: June 16, 2003Date of Patent: December 7, 2004Assignee: Medtronic, Inc.Inventors: Victor D. Dolecek, David Malcolm
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Patent number: 6740239Abstract: The claimed invention relates to a method and a device for processing blood concentrate products before they are exposed to a continued process for extracting those remaining medicinally interesting sub-components. The appropriate pre-processing, in relation to the invention, primarily entails a mechanically powered resolution of the viscous flowing concentrate products in a diluting solution for the adaptation of the total products for a renewed centrifuging. The device includes a centrifuge machine containing one or more suspended product bags that can be oscillated forwards and backwards in an incomplete pendulum swing by operation of a motor mounted in a lid of the machine. The product bag(s) are connected to a ring bag for subsequent processing and to a bag containing diluting solution by a multi-way connector.Type: GrantFiled: November 30, 2001Date of Patent: May 25, 2004Assignee: Gambro, Inc.Inventors: Niclas Högberg, Emanuel Hällgren, Peter Pihlstedt
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Patent number: 6719681Abstract: A multiple-component fluid mixture is separated by feeding the fluid mixture into a chamber of a vessel through an inlet, the chamber being at least partially bounded by a peripheral wall and the chamber also communicating with an outlet. The fluid mixture includes a heavy component and a light component. The vessel is rotated about a rotational axis extending through the vessel such that the heavy component collects toward at least a portion of the peripheral wall of the vessel and the light component collects toward the rotational axis. The light component is removed through the outlet channel. The heavy component is removed through a conduit disposed within the chamber, the conduit extending from the heavy component toward the rotational axis and out of the vessel.Type: GrantFiled: January 25, 2002Date of Patent: April 13, 2004Assignee: Econova, Inc.Inventor: Kevin E. Collier
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Patent number: 6689042Abstract: A centrifuge with an associated container system in the form of cassettes for separation and treatment of blood or blood components has been developed. The centrifuge includes a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around the cavity at the upper part thereof. A first container system is arranged in the rotor, for washing of blood cells, includes a round bag and two or more flexible secondary containers connected thereto, one of which contains a treatment liquid and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers are arranged in the sleeve to rest against each other and the round bag is mounted on a projecting flange at the upper part of the sleeve.Type: GrantFiled: January 22, 2002Date of Patent: February 10, 2004Assignee: Gambro, Inc.Inventors: Peter Unger, Eric Westberg
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Patent number: 6648809Abstract: The present invention relates to a centrifuge including a centrifugal drum, a supply pipe, a distributor, a displacement sleeve valve having an opening chamber and a closing chamber, a supply duct, a control gas feed in the distributor and a closing spring biasing the sleeve valve towards a closed condition during a pressure buildup in the opening chamber. The present invention also relates to a method of operating the centrifuge using a control gas to operate the sleeve valve and cleaning of control fluid paths by guiding a flushing fluid or flushing gas through the control fluid paths.Type: GrantFiled: November 5, 2001Date of Patent: November 18, 2003Assignee: Westfalia Separator AGInventors: Wilfried Mackel, Willi Niemerg, Thomas Kleimann
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Publication number: 20030119646Abstract: This invention provides a centrifugal weir that may be placed in series with conventional piping between a source of contaminated liquid and a discharge point within an industrial setting. Further, this weir allows continuous flow from the source of contamination to the discharge point without requiring settling ponds or reservoir systems. The centrifugal forces generated on the liquid inside the rotating weir greatly accelerate settling of heavy solid material from the liquid. The invention further provides a simplified means of cleaning the centrifugal weir. In a second embodiment, the centrifugal weir uses a removable cartridge. The compact unit of the second embodiment may be used in dental offices to separate amalgam from rinse water and for limited wastewater handling in chemistry laboratories.Type: ApplicationFiled: December 20, 2001Publication date: June 26, 2003Inventor: Lynn C. Lundquist
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Patent number: 6582349Abstract: Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.Type: GrantFiled: September 26, 2000Date of Patent: June 24, 2003Assignee: Baxter International Inc.Inventors: Robert J Cantu, Kyungyoon Min, Douglas W Reitz, Robert I Brown
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Publication number: 20030054934Abstract: Methods and apparatus for concentrating and recovering pathogens from a fluid other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through one or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).Type: ApplicationFiled: November 1, 2002Publication date: March 20, 2003Inventors: Richard I. Brown, Kyungyoon Min
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Patent number: 6475131Abstract: This invention provides a cleaning method for removing sediment from the inner wall of the rotary drum of a horizontal drum-type centrifugal separator which comprises charging a plurality of solid cleaning medium pieces such as globules, balls, cubes, rods, springs etc., into the rotary drum, supplying a cleaning liquid to the rotary drum, rotating the drum, and discharging the sediment together with the cleaning liquid. The solid cleaning medium is charged into the rotary drum either before centrifugal separation or at the time of cleaning after centrifugal separation.Type: GrantFiled: January 11, 2001Date of Patent: November 5, 2002Assignee: Tomoe Engineering Co., Ltd.Inventors: Takao Yoshida, Saihei Yano
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Publication number: 20020061808Abstract: A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor (1) having a central compartment in the form of a tubular shaft cavity (6) extending concentrically with the axis of rotation of the rotor and an annular separation compartment (5) which is arranged around said cavity at a the upper part thereof.Type: ApplicationFiled: January 22, 2002Publication date: May 23, 2002Applicant: Gambro, Inc.Inventors: Peter Unger, Eric Westberg
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Patent number: 6390964Abstract: The invention relates to a centrifuge and to a method for operating the centrifuge. The centrifuge comprises a centrifugal drum, an inflow tube leading into the centrifugal drum for feeding a centrifugal material into the centrifugal drum, and a valve mechanism, which can be acted upon by control fluid, for cooling the centrifugal drum. The control fluid is cooled such that it acts as a cooling medium.Type: GrantFiled: October 27, 2000Date of Patent: May 21, 2002Assignee: Westfalia Separator AGInventor: Wilfried Mackel
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Patent number: 6358193Abstract: In a centrifugal rotor (1) for separation of a substance from a liquid mixture supplied to the centrifugal rotor there is delimited a separation chamber (7) having peripheral outlets (30). The centrifugal rotor includes an outlet device (20-28) for intermittent opening and closing of the outlets (30) during rotation of the centrifugal rotor. An actuation device (31-40) may cause the outlet device (20-28) to keep the outlets (30) open to a varying extent and/or during a varying time, and a control device (43) is adapted to control the actuation device (31-40) in response to a sensed value of the amount of mixture supplied to the rotor, such that a predetermined amount of separated substance (29) having collected in the separation chamber (7) is discharged through the outlets (30) each time these are opened and closed.Type: GrantFiled: March 3, 2000Date of Patent: March 19, 2002Assignee: Alfa Laval ABInventor: Sven Olof Nyberg
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Patent number: 6348031Abstract: A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around said cavity at the upper part thereof. A first container system arranged in the rotor for washing of blood cells comprises a round bag with two or more flexible secondary containers connected thereto, of which at least one contains a treatment liquid, and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers stand in the sleeve resting against each other, and the round bag is mounted on a projecting flange at the upper part of the sleeve.Type: GrantFiled: August 12, 1999Date of Patent: February 19, 2002Assignee: Gambro, Inc.Inventors: Peter Unger, Eric Westberg
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Patent number: 6319186Abstract: In a particular type of centrifugal rotor for dividing a liquid mixture into one liquid phase having a low viscosity and one concentrate phase having a high viscosity, the concentrate phase on its way towards an outlet chamber (17) in the rotor has to flow through a vortex device (20). The vortex device has a property of admitting therethrough a larger flow of a liquid if this has a high viscosity than if it has a low viscosity. For making an operation for cleaning of the rotor and conduits for concentrate phase downstream of the rotor more efficient, a cleaning liquid, which has a low viscosity, is conducted not only through the vortex device (20) to said outlet chamber (17) for concentrate phase but to this outlet chamber (17) also through a separate passage (34). Thereby, it is guaranteed that a sufficient flow of cleaning liquid enters the concentrate outlet chamber (17) and from there can be pumped out of the rotor to the concentrate phase conduits downstream of the rotor.Type: GrantFiled: March 29, 2000Date of Patent: November 20, 2001Assignee: Alfa Laval ABInventor: Jouko Pitkämäki
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Patent number: 6309606Abstract: A device and a method are provided to efficaciously and rapidly separate human or animal cells of different densities from the dispersions which contain them, the device comprising an elongated chamber containing at least a first channel, one end of which opens on the inside of the chamber near the base and a second channel whose end opens in the chamber at a level corresponding to the top of the device, and wherein there is at least a third additional channel, one end of which opens at an intermediate level of the chamber; and the method comprises introducing a dispersion of such cells into the chamber previously filled with a liquid with increasing density gradient, followed by centrifugation and by recovering the distinct fractions of cells with different densities through at least one hole situated at an intermediate level of the chamber length.Type: GrantFiled: April 3, 2000Date of Patent: October 30, 2001Inventor: Giammaria Sitar
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Patent number: 6302836Abstract: An ordinary vacuum blood collection tube assembly is rotated about its longitudinal axis to partition a blood sample into serum and formed elements by centrifugation. While still rotating a higher density, immiscible inert liquid is pumped into the vacuum blood collection tube assembly thereby displacing lower density serum towards the axis of rotation and thence out of the vacuum blood collection tube assembly to a serum receiver vessel. A contaminant detector located on the serum delivery conduit controls a 3 way valve to divert contaminants from the removed serum to a waste vessel so only clean serum is delivered to the serum receiver vessel. The serum delivery conduits, serum cannula, and contaminant detector are washed and dried between successive samples to limit sample carryover effects to acceptably low levels.Type: GrantFiled: September 22, 1999Date of Patent: October 16, 2001Inventor: Howard L. North, Jr.
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Patent number: 6221315Abstract: Apparatus for separating a biological component from a biological fluid are disclosed. The apparatus includes a chamber for receiving a biological fluid including a biological component, and a rotor for creating a centrifugal field within the chamber. A source of particles may be included wherein the particles have a binding site for selectively binding to the biological component. The particles may be aseptically introduced into the chamber. The apparatus may withdraw whole blood from a donor, separate the whole blood to obtain a target cell population and return a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in conjunction with a rotatable separation device such as the apparatus described above may also be provided.Type: GrantFiled: April 12, 1999Date of Patent: April 24, 2001Assignee: Baxter International Inc.Inventors: Richard Giesler, John R. Chapman, Dale R. Ellis, Daniel F. Bischof
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Patent number: 6217502Abstract: In a centrifugal rotor (2) for freeing a liquid from solid particles suspended therein and being heavier than the liquid there is delimited a separation chamber (20), in which one or more conveyor screws (29) are arranged to supply separated particles axially along a surrounding wall (17) of the rotor. Each conveyor screw (29) is connected with a drivable bearing member (31) through a transmission shaft (38) extending out through one end wall (13) of the rotor. This bearing member (31) is journalled in the centrifugal rotor (2) and is situated in a transmission chamber (47) formed between said end wall (13) and a further wall (46).Type: GrantFiled: December 29, 1999Date of Patent: April 17, 2001Assignee: Alfa Laval ABInventors: Ingvar Hällgren, Hans Martin, Berndt Nyström
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Patent number: 6193643Abstract: The invention refers to a decanter centrifuge particularly for sludge centrifugation, incorporating a drum, a rotor arranged therein and equipped with a helical screw for feed of sludge, a sludge outlet and a reject outlet and a flush washing device for washing (flushing) in countercurrent to the dewatered sludge. In the rotor in close connection to the blades of the helical screw are provided a number of threaded holes for connection of the nozzles of the flush washing device. In response to the washing requirement, certain or entire groups of threaded holes are closable by means of sealing plugs, so that the washing (flushing) can be effected in several consecutive steps with portions without flushing in between.Type: GrantFiled: October 29, 1998Date of Patent: February 27, 2001Assignee: Noxon ABInventor: Lars-Åke Larsson
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Patent number: 6168561Abstract: Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.Type: GrantFiled: August 19, 1999Date of Patent: January 2, 2001Assignee: Baxter International Inc.Inventors: Robert J Cantu, Kyungyoon Min, Douglas W Reitz
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Patent number: 6080098Abstract: In a centrifugal rotor there is an inlet chamber (7), a separation chamber (8) and an outlet chamber (10), which chambers are coupled in series. A stationary outlet member (16) is arranged to remove from a predetermined level in the outlet chamber (10) separated liquid during normal operation of the centrifugal rotor. For internal cleaning of the centrifugal rotor there is arranged within the outlet chamber (10) inside said predetermined radial level a preferably stationary reconducting member (26) that is dimensioned to accomplish a recirculation flow of cleaning liquid through said chambers (7, 8, 10) in the centrifugal rotor, which circulation flow is substantially larger than the flow of liquid which during normal operation of the centrifugal rotor passes through these chambers.Type: GrantFiled: May 8, 1998Date of Patent: June 27, 2000Assignee: Alfa Laval ABInventors: Leonard Borgstrom, Patrik Brehmer, Claes-Goran Carlsson, Peter Franzen, Claes Inge, Torgny Lagerstedt, Hans Moberg, Stefan Szepessy
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Patent number: 6015375Abstract: A centrifuge has a centrifugal drum with a peeling chamber and a hydrohermetic chamber (locking chamber) (7). The centrifuge is so designed that solids deposited at the periphery (outer bottom 19) of the locking chamber (7) are carried away with the overflow stream of the sealing liquid or/and with the flow of the cleaning medium during CIP method of the space located between the centrifugal drum (2) and the centrifuge housing. A second locking chamber lid (1) is located between a locking disk (9) of the locking chamber (7) and a lid (17) for forming with the first lid a flow channel (20) for carrying away solids deposited on the outer bottom of the locking chamber via an overflow weir (16). The centrifuge is used in the field of separation technology, in particular when high hygienic requirements are applied, e.g. in the field of the foodstuff industry.Type: GrantFiled: July 17, 1998Date of Patent: January 18, 2000Assignee: Westfalia Separator AGInventor: Reinhard Moss
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Patent number: 6011490Abstract: Apparatus for measurement concerning fluids in a rotor or container (2) during rotation, comprising an electric or magnetic sensor (4) mounted internally on a wall in the container (2), and means (5A, 5B) for contact-free and intermittent transmission of measurement signals from the sensor (4) to a stationary measuring unit (7) outside the container. The sensor (4) comprises an active electronic circuit (8) adapted to store measurement values that are recorded during at least a portion of a revolution of the container (2), before said transmission of corresponding measurement signals to the measuring unit (7). Electric power supply to the electronic circuit (8) is provided for by generator means comprising a stationary magnet (11) near the container (2) and a coil (12) mounted in the container so that a voltage is induced in the coil (12) during movement past the magnet (11) during the rotation of the container (2).Type: GrantFiled: September 12, 1997Date of Patent: January 4, 2000Assignee: Exxon Production Research CompanyInventors: Harald Tonnesen, Per Scholberg Henriksen, Truls Fallet
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Patent number: 5985037Abstract: A stable self-forming density gradient is created by applying a centrifugal field to a solution that contains 27-33% Percoll (v/v) and 36-44% sugar (w/w). This density gradient is stable for several hours, allowing separation of low sedimentation particles, such as subcellular particles.Type: GrantFiled: April 23, 1998Date of Patent: November 16, 1999Assignee: Beckman Coulter, Inc.Inventors: Melvin Dorin, Paul J. Voelker
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Patent number: 5948256Abstract: A centrifuge includes a conveyor for moving cake along a cake flow path towards a cake discharge opening and further includes a baffle mounted to the conveyor and disposed along the cake flow path. The baffle is provided on an upstream side, facing substantially away from the discharge opening, with a concave profile or surface. This concave profile or surface serves to direct a portion of the cake, which is headed downstream along the cake flow path, into a recirculation or churning path directed partly back towards a pool. The recirculation or churning of the particulate material facilitates an enhanced washing thereof and improves the removal of valuable solutes or undesirable impurities from the cake.Type: GrantFiled: January 14, 1998Date of Patent: September 7, 1999Assignee: Baker Hughes IncorporatedInventor: Woon-Fong Leung
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Patent number: 5944649Abstract: Method and device (21) for the supply of control liquid to a rotor of a centrifugal separator, which device (21) includes a cylinder (25), in which a movable wall element (26) is arranged, which axially delimits a storing chamber (29) in the cylinder (25). In the storing chamber (29) a predetermined volume of control liquid is stored. Control liquid is pressed out of the storing chamber (29) into the rotor during axial displacement of the wall element (26). Furthermore, the invention includes a centrifugal separator, which is provided with such a device (21). A portion of the control liquid in the storing chamber (29) is pressed upon displacement of the wall element (26) a first distance out through a first outlet passage (33) in the device with a high flow. The first outlet passage (33) is then closed when the wall element (26) has been displaced this distance.Type: GrantFiled: July 24, 1998Date of Patent: August 31, 1999Assignee: Alfa Laval ABInventor: Per Gunnar Karlsson
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Patent number: 5935432Abstract: A device for separating components, such as fibrin I from blood, by way of centrifugation about a central axis of rotation comprises a first annular chamber defined by an outer cylindrical wall and an inner cylindrical wall, both walls being concentrically accommodated about the axis of rotation, and by a top wall and a bottom wall, where the top wall or the bottom wall is formed by a piston body displaceable within the first chamber. The device comprises furthermore a second chamber communicating with said first chamber through a first conduit and being defined by an outer cylindrical wall concentrically accommodated about the axis of rotation, said bottom wall of the first chamber, and another bottom wall. The second chamber is adapted to be placed below the first chamber during the centrifugation.Type: GrantFiled: November 6, 1997Date of Patent: August 10, 1999Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5902224Abstract: A gas separation centrifuge is provided with a housing having a top, a bottom and a plurality of joined side walls parallel to an axis and forming a predetermined regular polygon cross-sectional shape perpendicular to the axis. A rotor is mounted for coaxial rotation within the housing, including a plurality of inverted truncated pyramid plates forming the predetermined regular polygon shape at an outer periphery, and forming the predetermined regular polygon shape at an interior edge. The plurality of inverted truncated pyramid plates are stacked coaxially and are axially spaced apart to form planar channels therebetween and define an interior annular volume with openings therefrom into the planar channels. There are also openings through the outer periphery. A first plurality of stationary concentric input tubes extends into the interior annular volume.Type: GrantFiled: March 14, 1997Date of Patent: May 11, 1999Assignee: Fuge Systems, Inc.Inventor: Michael R. Bloom
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Patent number: 5899844Abstract: A method and apparatus for controlling the density of the solids separated from a feed slurry by selectively recirculating the separated liquid component of the feed slurry to change the feed slurry's density when an unwanted density of the separated solids is detected. Further, the efficiency of the separation is increased by recirculating and recharging unused catalyst into the feed slurry where it is used to assist in the separation of the solids.Type: GrantFiled: June 23, 1997Date of Patent: May 4, 1999Inventor: Louis C. Eberle, Sr.
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Patent number: 5865719Abstract: A self-emptying centrifuge drum has a collecting channel for emptying the drum and a fitting for introducing water into the collecting channel. The drum is rotatable and is hydraulically actuatable by water introduced into the collecting channel through the fitting. The collecting channel rotates with the drum about an axis of rotation and the fitting is stationary and has at least one outlet. A baffle extends up from below the collecting channel and between the collecting channel and the fitting and has a lower portion below the collecting channel and an upper portion extending into an area radially inward of the collecting channel with respect to the axis of rotation. The at least one outlet of the fitting is aimed at the lower portion of the baffle.Type: GrantFiled: March 7, 1997Date of Patent: February 2, 1999Assignee: Westfalia Separator AGInventors: Johannes Droste, Norbert Wegener
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Patent number: 5830352Abstract: A reagent delivery system comprises an axial hub passing through the center of two equal-diameter, spaced apart discs, wherein the hub and discs are positioned in a sleeve such that an annular reagent chamber is provided. When the sleeve is moved in either an up or down axial direction the so-formed chamber is opened and the reagent is released. Such a regent delivery system is particularly useful in a centrifuge for concentrating or preparing blood products.Type: GrantFiled: December 1, 1995Date of Patent: November 3, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5785637Abstract: A centrifuge for a fluid uses a series of centrifugal modules to separate the fluid from particles suspended in the fluid. The fluid enters through the bottom of the centrifuge and is subjected to the centrifugal force by a set of rotors. The fluid is forced against a campanula which allows the fluid to travel upwards but forces particles downward. The fluid progresses into another module which exerts a greater centrifugal force until the purified liquid exists through the top of the centrifuge.Type: GrantFiled: October 30, 1996Date of Patent: July 28, 1998Inventors: Fernando A. Baptista, Joao M. Pereira Dias Baptista
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Patent number: 5723050Abstract: Apparatus for centrifugal separation of liquid mixtures is disclosed including an inner circular bag and an outer annular bag which has an inner diameter corresponding to the outer diameter of the inner circular bag, a connecting channel for providing fluid communication between the inner and outer bags, and a rigid circular mount for mounting the outer annular bag for centrifugation in a manner such that the outer annular bag adopts a conical configuration by shortening its inner diameter. Methods for centrifugal separation of thrombocyte suspensions and bone marrow cells using this apparatus are also disclosed.Type: GrantFiled: January 3, 1996Date of Patent: March 3, 1998Assignee: Omega Medicinteknik ABInventors: Peter Unger, Eric Westberg
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Patent number: 5653673Abstract: Centrifugal apparatus for the continuous separation of solids-liquid mixtures and the internal washing of separated solids is provided with one or more conduits to deliver washing liquid into centrifugally sedimented solids tumbling and suspending these solids in washing liquid. A distal end of each wash conduit is positioned in close proximity to the inner surface of the centrifuge bowl near the conveyor blade which is adapted to contact the solids upon separation and propel separated solids toward the solids discharge port. The invention includes centrifugal apparatus provided with plurality of cutting tools such as knife blades adapted to cut and separate the sedimented solids. In another aspect of the invention centrifugal apparatus is provided with one or more dip weirs dividing the centrifugally separated liquid pool in the bowl into axially adjacent zones with suitable a passageway for transfer of liquids and solids between adjacent zones.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: Amoco CorporationInventors: Vikram J. Desai, John W. Caldwell, Alan G. Letki
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Patent number: 5634876Abstract: A scale modelling centrifuge has a relatively massive rotary circular base wall, which may form part of a drum, possibly with a detachable peripheral wall either carrying an annular sample-receiving trough or constituted by such trough, or which may have mounted therearound a plurality of sample-receiving containers.Type: GrantFiled: December 13, 1993Date of Patent: June 3, 1997Inventor: Andrew N. Schofield
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Patent number: 5618409Abstract: The centrifuge (1) described has at least one device (11,12) designed to control the operation of the centrifuge, the devices being mounted to rotate with the rotating part of the centrifuge and to be operated by a mechanical actuator (13) also rotating with it. Such devices may, for instance, be drain valves, periodically opening discharge valves, sill height adjustment devices, pressure-control devices, temperature-control devices, etc. At least one part of the devices of this centrifuge to be controlled independently of the centrifugal force is designed so that the rotating actuator (13) changes its shape as a function of the temperature and has at least one temperature-specific shape.Type: GrantFiled: August 12, 1994Date of Patent: April 8, 1997Assignee: FLottweg GmbHInventor: Walter Kreill
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Patent number: 5616245Abstract: A separator includes a housing, a basket rotatably mounted in the housing and a movable weir member. The basket has an upstream end portion, a downstream end portion and an intermediate tubular portion that includes or forms a screen deck. The weir member is movable between a first position where a portion of the weir member extends radially inward relative to the inner surface of the downstream open end portion and a second position spaced from the first position. In this manner, the weir member forms a movable dam adjacent the downstream end portion of the basket. In operation, feed material is fed into the basket as the basket is rotated. The heavy fractions of the material pass transversely through the basket (i.e., the tubular portion that forms a screen deck) and report to a first outlet from which the heavy fractions are collected.Type: GrantFiled: May 19, 1995Date of Patent: April 1, 1997Assignee: HJS Clem AGInventor: Michael C. Albrecht
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Patent number: 5372571Abstract: A centrifugal separator of the type comprising a bowl having a base and a peripheral wall surrounding a vertical axis about which the bowl rotates and a jacket having a base plate under the base of the bowl and a sleeve surrounding the peripheral wall includes a central bottom discharge for the concentrate. The bowl is mounted on the shaft with a hub connecting the shaft to the base plate of the jacket. Water is supplied through the shaft and into the area of the base of the bowl. Tubular discharge ducts extend from holes in the base plate across the space under the bowl to the base plate of the jacket. These remain open during processing of feed materials supplied to the bowl through a vertical tube feeding onto a base plate carried by the bowl above the tubular ducts, and allow the concentrate washed down from the wall of the bowl to discharge when the feed and the centrifugal action of the bowl are halted.Type: GrantFiled: June 22, 1993Date of Patent: December 13, 1994Assignee: Benjamin V. KnelsonInventors: Benjamin V. Knelson, Andre Cauchon
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Patent number: 5372945Abstract: Methods and apparatus for collecting and processing tissue to produce an endothelial cell product having a vessel for rinsing, draining, digesting and isolating tissue. The vessel has a rinsing and digesting chamber for containing tissue during processing. An inlet in the rinsing and digesting chamber allows entry of rinsing solution and tissue from a liposuction device. A waste chamber in fluid communication with the rinsing and digesting chamber preferably connects with a vacuum source. An isolation chamber is separated from the rinsing and digesting chamber by a screen. An ampule in fluid communication with the isolation chamber includes a pair of ports controlled by valve devices to be selectively in fluid communication with the isolation chamber. After processing, the ampule isolates a pellet of endothelial cells and the valve devices permit the pellet to be in fluid communication with the ports.Type: GrantFiled: July 31, 1992Date of Patent: December 13, 1994Inventors: Paul G. Alchas, Alfred W. Prais, Bruce E. Jarrell, Stuart K. Williams, Joseph A. DiPisa, Jr.
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Patent number: 5222933Abstract: A centrifugal separator of the type comprising a bowl having a base and a peripheral wall surrounding a vertical axis about which the bowl rotates and a jacket having a base plate under the base of the bowl and a sleeve surrounding the peripheral wall includes a central bottom discharge for the concentrate. The bowl is mounted on the shaft with a hub connecting the shaft to the base plate of the jacket. Water is supplied through the shaft and through a pair of ducts passing through the hub and into the area of the base of the bowl. The discharge also extends through the hub through a pair of ducts which diverge from the central discharge opening outwardly and downwardly into a collection chamber. The discharge duct portions through the hub are angularly offset from the water supply duct portions through the hub so that both can be formed in the hub.Type: GrantFiled: March 20, 1992Date of Patent: June 29, 1993Assignee: Benjamin V. KnelsonInventors: Benjamin V. Knelson, Andre Cauchon
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Patent number: 5196068Abstract: A water-conducting lance, fitted with a spray nozzle at an end thereof, is fixed to the top of a massecuite-separating centrifuge which has a rotating basket, to dispose the nozzle in adjacency to the top of the basket. The nozzle addresses the top of the basket, perpendicularly, and sprays pre-wetting water onto sugar crystals thereat, to insure a good mix of the crystals with subsequent mixing liquid (also water) in a mixing liquid zone, in order that a lump-free high brix magma will be produced.Type: GrantFiled: November 18, 1991Date of Patent: March 23, 1993Assignee: Silver Engineering Works, Inc.Inventor: Ted D. Milner
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Patent number: 5186844Abstract: An analytical rotor for separating cellular components from a biological fluid includes a separation chamber spaced radially outward from a sample chamber. The sample chamber may be an open receptacle disposed to receive sample or may be a mixing chamber which receives sample and diluent. A flow restrictive channel connects the sample chamber to the separation chamber so that fluid enters the separation chamber at a controlled rate. The cellular components collect within a retention region located generally at the outer periphery of the collection chamber while cell-free fluid is continuously removed through a collection port. The collection port is spaced annularly apart from the flow channel so that there is sufficient residence time within the separation chamber for substantially complete separation of the cells from the fluid fraction.Type: GrantFiled: April 1, 1991Date of Patent: February 16, 1993Assignee: Abaxis, Inc.Inventors: Tammy L. Burd, Carol T. Schembri
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Patent number: 5167609Abstract: The peeling chamber in a head of a centrifuge has an upstream barrier chamber that seals it off from the atmosphere. A barrier disk secured to a peeler extends into the barrier chamber. Compressed gas is supplied to between barrier disk and peeler through a channel to prevent gas from escaping from the solvent. Another channel supplies liquid to the barrier chamber. Solvent from the periphery is supplied to the barrier chamber through a channel and simultaneously by the peeler through the barrier-liquid channel. An area of separation becomes established between the two liquids in the barrier chamber. If any solid particles enter the barrier chamber as the result of gas leaving the solvent, they will dissolve again in the solvent in the periphery of the barrier chamber and will be prevented from making the chamber malfunction.Type: GrantFiled: April 30, 1991Date of Patent: December 1, 1992Assignee: Westfalia Separator AGInventors: Georg Graw, Werner Kohlstette, Herbert Hohmann, Detlef Grabbe