Miscellaneous Patents (Class 506/43)
  • Patent number: 9678013
    Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: June 13, 2017
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Alexandre M. Bratkovski, Zhiyong Li, Wei Wu, Min Hu, R. Stanley Williams, Ansoon Kim
  • Patent number: 8975216
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: March 10, 2015
    Assignee: Pacific BioSciences of California
    Inventors: David Rank, Jonas Korlach, Yue Xu, Stephen Turner, Jeffrey Wegener, Daniel Roitman, John Lyle
  • Publication number: 20150005180
    Abstract: A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.
    Type: Application
    Filed: September 17, 2004
    Publication date: January 1, 2015
    Inventors: Kazuhiko Ishihara, Sohei Funaoka, Kanehisa Yokoyama
  • Publication number: 20140364342
    Abstract: Provided is a microarray processing apparatus which is capable of sufficiently washing a microarray. The microarray processing apparatus (30) includes a well plate (38) in which one or two or more wells (40) are formed, each well (40) accommodating a microarray (1), and a suction nozzle (46) that suctions a liquid from the well. The well has a concave portion whose upper end is opened, which has a depth equal to or greater than a height of the microarray, and into which a front end of the suction nozzle can be inserted up to a height position of a lower end of the microarray accommodated in the well. The suction nozzle can relatively descend in the well until the front end of the suction nozzle is located at the height position of the lower end of the microarray accommodated in the well.
    Type: Application
    Filed: April 4, 2013
    Publication date: December 11, 2014
    Applicant: Mitsubishi Rayon Co., Ltd.
    Inventor: Kouji Shimizu
  • Publication number: 20140274814
    Abstract: A removable microfluidics structure comprising at least one actuated fluid delivery element, wherein the actuated fluid delivery element is a pump element of a valve element configured to control fluid delivery to or from a removable media detachably coupled with the removable microfluidics structure based on an actuation force. The actuation force is an external actuation force or an internal actuation force. The removable microfluidics structure may include an electromechnical actuator for providing the actuation force, such as a solenoid, a solenoid with an ferromagnetic core or a piezoelectric actuator. The removable microfluidics structure may further include a coupling mechanism for detachably coupling the removable microfluidics structure with the removable media, such as a cell array, such that when the microfluidics structure couples with the removable media, the microfluidics structure controls fluid delivery to or from a cell of the cell array.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventor: Lester Ludwig
  • Publication number: 20140256598
    Abstract: Methods and systems for venting a well that receives a liquid. The method includes providing a microplate including a well that has a cavity with an open inlet and a closed end. The cavity extends between the open inlet and the closed end. The cavity is defined by a wall surface having a cross-sectional contour that includes at least one continuous section and at least one discontinuity section. The method also includes depositing a liquid into the open inlet of the well. The liquid enters the cavity and flows toward the closed end to at least partially fill the well. The liquid flows along the continuous section of the wall surface and remains separated from the discontinuity section of the wall surface, thereby maintaining a gas exhaust path along a spacing between the liquid and the discontinuity section as the liquid flows toward the closed end.
    Type: Application
    Filed: May 21, 2014
    Publication date: September 11, 2014
    Applicant: ILLUMINA CORPORATION
    Inventor: CHAD F. DEROSIER
  • Patent number: 8802600
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: August 12, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron Cicero
  • Patent number: 8772202
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: July 8, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffrey Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ronald L. Cicero
  • Patent number: 8735327
    Abstract: DNA taggants in which the nucleotide sequences are defined according to combinatorial mathematical principles. Methods of defining nucleotide sequences of the combinatorial DNA taggants, and using such taggants for authentication and tracking and tracing an object or process are also disclosed.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: May 27, 2014
    Assignee: Jeansee, LLC
    Inventor: Anthony J. Macula
  • Patent number: 8652796
    Abstract: The present invention provides methods and compositions for detecting protein-protein and/or protein-nucleic acid interactions in cells.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: February 18, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Max L. Nibert, Cathy Lea Miller, Teresa J. Broering
  • Publication number: 20140031262
    Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 30, 2014
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Tanya S. Kanigan, Steve Smith, John Linton, Robert Hess, Karl Yoder, Colin Brennan
  • Patent number: 8633140
    Abstract: A microarray includes a solid substrate having a surface, the surface having a plurality of binding spots and a plurality of reaction moieties bound to the binding spots. A reaction moiety includes a plurality of polyacetylene monomers, the polyacetylene monomers having a first coupling region and a second coupling region, the first coupling region having a first functional group operable to bind to the binding spot and the second coupling region comprising a second functional group operable to bind to an accessory molecule; and an accessory molecule having a binding region and an analyte reaction region, the analyte reaction region operable to selectively bind to the target analyte, and the binding region operable to bind to the second coupling region of the polyacetylene monomer. Upon binding a target analyte with the reaction moiety, a color change from the polyacetylene monomer occurs and the reaction moiety produces fluorescence.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: January 21, 2014
    Assignee: The Regents of The University of Michigan
    Inventors: Jinsang Kim, Jiseok Lee
  • Publication number: 20140018265
    Abstract: In one embodiment, a biosample storage cartridge includes an enclosure having a same form factor as a data tape cartridge configured for use in an automated tape library; and a holder disposed in the enclosure. In another embodiment, a biosample storage cartridge includes an enclosure and a holder disposed in the enclosure; the holder is configured to receive one or more biosamples, the cartridge is structurally configured to be picked by a picker of an access robot that is configured to pick a data tape cartridge in an automated tape library. In still another embodiment, an analytical system includes a bioanalysis drive configured to perform bioanalysis on one or more biosamples received from at least one biosample storage cartridge.
    Type: Application
    Filed: September 17, 2013
    Publication date: January 16, 2014
    Applicant: International Business Machines Corporation
    Inventors: Allen K. Bates, Nils Haustein, James W. Johnson, Stephen L. Schwartz, Anna W. Topol, Daniel J. Winarski
  • Patent number: 8603303
    Abstract: Apparatus, system, and method are provided for cutting a linear charged polymer inside a nanopore. A first voltage is applied to create an electric field in a first direction. A second voltage is applied to create an electric field in a second direction, and the first direction is opposite to the second direction. When the electric field in the first direction and the electric field in the second direction are applied to a linear charged polymer inside a nanopore, the linear charged polymer is cut at a location with predetermined accuracy.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: December 10, 2013
    Assignee: International Business Machines Corporation
    Inventors: Binquan Luan, Glenn J. Martyna, Hongbo Peng, Gustavo A. Stolovitsky
  • Publication number: 20130316927
    Abstract: The invention provides a novel array method for nucleic acid sequence detection with improved specificity which allows for detection of genetic variation, from simple SNPs (where the variation occurs at a fixed position and is of limited allelic number) to more complex sequence variation patterns (such as with multigene families or multiple genetic strains of an organism where the sequence variation between the individual members is neither fixed nor consistent). The array is comprised of short, synthetic oligonucleotide probes attached to a solid surface which are hybridized to single-stranded targets. Single stranded targets can be produced using a method that employs primers modified on the 5? end to prohibit degradation by a 5?-exonuclease that is introduced to degrade the unprotected strand. The invention further provides for printing buffers/solutions for the immobilization of oligonucleotide probes to an array surface.
    Type: Application
    Filed: June 6, 2013
    Publication date: November 28, 2013
    Inventors: Kerry B. Gunning, Mark Aaron Behlke
  • Publication number: 20130252847
    Abstract: The present invention relates to assay assemblies, components of assay assemblies, methods of determining one or more properties of a sample liquid, and methods of making components of assay assemblies. The present invention allows the properties of very small volumes of sample liquid to be probed, by providing a first surface having at least one sample liquid wettable surface region defined by a sample liquid repelling boundary, and a second surface, opposed to the first surface, having analyte binding agent immobilised thereon.
    Type: Application
    Filed: December 2, 2011
    Publication date: September 26, 2013
    Inventors: Ekaterina Olegovna McKenna, Yifan Li, Andrew Robert Pitt, Anthony John Walton, William Parkes
  • Publication number: 20130150265
    Abstract: The invention offers the ability to rapidly synthesize multiple chemical compounds, particularly polymers of varying sequences, in parallel on the surfaces of carrier beads. Tinvention involves attaching up-converting phosphors (UCP's) to beads to create up-converting phosphor-loaded beads (UCP-loaded beads) with unique spectral characteristics. Using a dynamic sorting architecture each bead is cataloged based on its spectral characteristics, assigned a compound or polymer to be synthesized, and subjected to multiple rounds of sorting by a flow cytometer, wherein each round sorts the bead to an appropriate bin for a selected chemical reaction, such as the attachment of a monomeric subunit of the polymer sequence.
    Type: Application
    Filed: February 9, 2011
    Publication date: June 13, 2013
    Inventors: Robert Balog, David E. Cooper, Steven Crouch-Baker, Alexander J. Hallock, Georgina Hum, Maheen Samad, Angel Sanjurjo
  • Patent number: 8425861
    Abstract: A fast, multiplexed PCR system is described that can rapidly generate amplified nucleic acid products, for example, a full STR profile, from a target nucleic acid. Such systems include, for example, microfluidic biochips and a custom built thermal cycler, which are also described. The resulting STR profiles can satisfy forensic guidelines for signal strength, inter-loci peak height balance, heterozygous peak height ratio, incomplete non-template nucleotide addition, and stutter.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: April 23, 2013
    Assignee: Netbio, Inc.
    Inventors: Richard F. Selden, Eugene Tan, Heung Chuan Lam, Heidi Susanne Giese, Gregory John Kellogg, John A. Wright
  • Publication number: 20130079252
    Abstract: A fluidic device for conveying liquid to a well of a microplate. The device includes a support structure configured to be mounted along the microplate. The device also includes a microfluidic tube coupled to the support structure. The tube has an inlet, an outlet, and an open-sided channel that extends longitudinally therebetween. The tube has a cross-section that includes an interior contour with a gap therein. The gap extends at least partially along a length of the tube. The tube is configured to convey liquid to the well of the microplate when the tube is held in a dispensing orientation.
    Type: Application
    Filed: November 20, 2012
    Publication date: March 28, 2013
    Applicant: ILLUMINA CORPORATION
    Inventor: Chad F. DeRosier
  • Publication number: 20120329681
    Abstract: The present invention generally relates to microfabricated devices for carrying out and controlling chemical reactions and analysis. In particular, the present invention provides systems, methods, devices and computer software products related to multiplex liquid handling systems utilizing lab cards related to biological assays.
    Type: Application
    Filed: June 15, 2012
    Publication date: December 27, 2012
    Applicant: AFFYMETRIX, INC.
    Inventors: Chuan Gao, Melvin Yamamoto, Devin Nguyen
  • Publication number: 20120329673
    Abstract: The invention provides vectors and methods designed for screening large random DNA fragment libraries for the presence of open reading frames that are free of both internal ribosome binding sites (IRBS) and stop codons. The invention overcomes the principal limitation of known ORF-selector systems, namely the potential for ORF-induced folding interference of the downstream fused reporter, by not fusing the reporter to the ORF, but rather by providing a mechanism for coupled translation of an unfused downstream reporter.
    Type: Application
    Filed: October 24, 2007
    Publication date: December 27, 2012
    Inventor: Geoffrey S. Waldo
  • Publication number: 20120309298
    Abstract: Embodiments of the disclosure relate to a biosample cartridge that includes storage slots for holding biosample plates. The cartridge has the same form factor as data tape cartridges to allow the cartridge to be handled by the same robotic mechanisms that handle data cartridges in an automated tape library. One aspect of the disclosure concerns a biosample storage cartridge that has a movable door to provide access to inside the cartridge and a plate holder disposed inside the cartridge. The plate holder includes a plurality of slots for receiving biosample plates that are scanned and processed by the automated tape library.
    Type: Application
    Filed: June 1, 2011
    Publication date: December 6, 2012
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Allen Keith Bates, Nils Haustein, James William Johnson, Stephen Leonard Schwartz, Anna Wanda Topol, Daniel James Winarski
  • Patent number: 8207069
    Abstract: An integrated processing tool is described comprising a full-wafer processing module and a combinatorial processing module. Chemicals for use in the combinatorial processing module are fed from a delivery system including a set of first manifolds. An output of each first manifold is coupled to at least one mixing vessel. An output of each mixing vessel feeds more than one of a set of second manifolds. An output of each set of second manifolds feeds one of multiple site-isolated reactors of the combinatorial processing module.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: June 26, 2012
    Assignee: Intermolecular, Inc.
    Inventors: Kurt H. Weiner, Tony P. Chiang, Aaron Francis, John Schmidt
  • Patent number: 8193123
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: June 5, 2012
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron Cicero
  • Publication number: 20120046202
    Abstract: An apparatus and system for stirring liquid inside a flow cell. In one implementation, the apparatus includes a rotatable disc configured to receive liquid at a top side of the disc and distribute the liquid substantially evenly around a periphery of the flow cell. The disc has a triangular cross sectional area. The apparatus may further include a set of fins attached to a bottom side of the disc, wherein the set of fins is configured to draw the liquid from the periphery of the flow cell into the center of the flow cell.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 23, 2012
    Applicant: Intermolecular, Inc.
    Inventor: Rajesh Kelekar
  • Patent number: 8114951
    Abstract: The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: February 14, 2012
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Ken James, Stephen Brochini, Varawut Tangpasuthadol, Joachim Kohn
  • Patent number: 8080412
    Abstract: A continuous temperature-gradient incubation apparatus designed to solve the problem of moving of liquid vapor generated on the high-temperature side toward the low-temperature side to thereby cause condensation.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: December 20, 2011
    Assignee: Research Organization of Information and Systems
    Inventor: Nobuo Shimamoto
  • Publication number: 20110301058
    Abstract: A novel approach for fabricating Monolithic Internal micro Pillars (MIPi) made of SU-8 photoresist is described. A microfluidic chip with the internal pillars (a MIPi chip) was used for cell capturing study. The surface of MIPi was coated with specific antibody and then used for capturing cells by affinity binding. An antibody, anti-EGFR, which has high affinity to lung cancer cells, CL1-5, was coated on the micro pillars. The coated MIPi chip specifically captured the cancer cells that were pumped through the MIPi chip. Simulation and experiment was carried out to compare the effect of different geometry of the micro pillars on the cell capturing rate.
    Type: Application
    Filed: June 8, 2011
    Publication date: December 8, 2011
    Applicant: ACADEMIA SINICA
    Inventors: Ji-Yen Cheng, Joel Chia-Yeh Chang, Ching-Wen Yang
  • Patent number: 7985882
    Abstract: A modified solid-support for use as a supported reagent for use in reduction reactions, including reductive amination comprising a solid-support having an tetrasubstituted ammonium cation species ionically bonded to a borohydride anion species extending therefrom having the general formula: wherein P is a solid-support, S is a spacer group selected from the group consisting of alkylene, {including —(CH2)n—}, alkyleneoxy {including -0(CH2)n—}, alkylenethio {including —S(CH2)n—} and alkylenecarboxy, {including —O(O)C—(CH2)n—}, n=2-16. R1, R2, R3 and R are each independently selected from the group consisting of alkyl, cycloalkyl, haloalkyl and aryl. Y equals 1, 2 or 3. H is hydrogen or deuterium.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: July 26, 2011
    Assignee: Biotage AB
    Inventors: Sukanta Bhattacharyya, Jeffrey W. Labadie, Owen W. Gooding, Sunil Rana
  • Publication number: 20110160085
    Abstract: Methods and kits for the assessment of the suitability of and/or effectiveness of a target therapy for a TNF mediated-related disorder, such as ulcerative colitis, in a subject, which methods and kits evaluate the presence, absence, and/or magnitude of expression of two or more genes up or down regulated in association with anti-TNF responders in inflammatory gastrointestinal disorders, such as ulcerative colitis
    Type: Application
    Filed: August 19, 2009
    Publication date: June 30, 2011
    Inventors: Katherine Li, Frederic Baribaud
  • Patent number: 7923533
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: April 12, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7910695
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: March 22, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Publication number: 20110065108
    Abstract: A method of stabilizing a patient sample such as a urine sample to prevent degradation of nucleic acids for subsequent analysis for pathogen detection involves adding a stabilizing solution to an aliquot of the sample. A stabilizing solution comprising a chaotrope, a non-ionic detergent, and a buffer preserves urine samples for at least 28 days at room temperature for storage and transportation to an analytical facility for screening for pathogen nucleic acids.
    Type: Application
    Filed: January 29, 2009
    Publication date: March 17, 2011
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventors: David Sherman, Qi Meng
  • Publication number: 20110053790
    Abstract: A live cell of microorganism in a test sample is detected by the following steps of: a) adding a cross-linker capable of cross-linking a DNA by irradiation with light having a wavelength of 350 nm to 700 nm to the test sample; b) irradiating the test sample to which the cross-linker is added with light having a wavelength of 350 nm to 700 nm; c) removing the cross-linker contained in the test sample irradiated with light; d) adding a medium to the test sample from which the cross-linker is removed and incubating the test sample; e) adding again the cross-linker capable of cross-linking a DNA by irradiation with light having a wavelength of 350 nm to 700 nm to the incubated test sample; f) irradiating the test sample to which the cross-linker is added with light having a wavelength of 350 nm to 700 nm; g) extracting a DNA from the test sample and amplifying a target region of the extracted DNA by a nucleic acid amplification method; and h) analyzing the amplified product.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 3, 2011
    Applicant: Morinaga Milk Industry Co., Ltd.
    Inventors: Shinichi Yoshida, Takashi Soejima
  • Patent number: 7888465
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 15, 2011
    Assignee: The Invention Science Fund, I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7879974
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 1, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7879973
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: February 1, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7879975
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: February 1, 2011
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7872096
    Abstract: The invention provides methods and compositions for production of a cyclic polymer in a cell free system. In general, the methods of the invention involve ligating first and second recombinant intein domains to a linear synthetic polymer to form a compound containing the structure: D1-X(n)-D2, where D1 is a first catalytic domain of an intein; D2 is a second catalytic domain of an intein; where the second catalytic domain has at its N-terminus a first reactive site for the intein; and X(n) is a polymer of a number n of monomer X, where the polymer N-terminus has a second reactive site for the intein. D1-X(n)-D2 compounds autocatalytically cyclize the X(n) polymer to produce a cyclic polymer. The invention finds use in a variety of drug discovery, clinical and therapeutic applications.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: January 18, 2011
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventor: Todd M. Kinsella
  • Patent number: 7867391
    Abstract: The present disclosure provides a cucurbituril derivative-bonded solid substrate in which cucurbituril derivatives of Formula 1 are covalently bonded to a modified solid substrate of Formula 2. The cucurbituril derivative provides functional groups which can be used to link biomaterials to the substrate. Protein chips, gene chips, and sensors for biomaterial assays having the cucurbituril derivative-bonded solid substrate are also provided.
    Type: Grant
    Filed: July 5, 2004
    Date of Patent: January 11, 2011
    Assignee: Postech Foundation
    Inventors: Kimoon Kim, Jin Koo Kang, Woo Seong Jeon, Sang Yong Jon, Selvapalam Narayanan, Dong Hyun Oh, Kangkyun Baek
  • Patent number: 7838261
    Abstract: A method for biochemical analysis uses a micro-reaction array with at least two reaction chambers for materials which react together chemically or biochemically. The reaction chambers are smaller than 1 ?l, the reaction chambers are filled together by throughflow, the chemical or biochemical reactions of the substances retained therein then occurs in the individual isolated reaction chambers, thus preventing an interference between the reactions in the individual reaction chambers and the reaction products remain enclosed in the relevant reaction chambers. In the system the planar array has at least two reaction chambers for substances, whereby the reaction chambers are closed with the goal of preventing an exchange of substances.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: November 23, 2010
    Assignee: Siemens Aktiengesellschaft
    Inventors: Walter Gumbrecht, Rainer Hintsche, Konrad Mund, Manfred Stanzel
  • Publication number: 20100222226
    Abstract: To provide an electronic component mounting system and an electronic component mounting method which can prevent a mounting failure due to positional error in a height direction of a substrate and ensure mounting quality. The electronic component mounting system includes a plurality of electronic component mounting devices connected to one another and mounts an electronic component on a substrate to manufacture a mounting substrate. A print test device for testing the substrate after solder printing measures a height position of a height measurement point set on the upper surface of the substrate 4 by a height measuring machine 22 and outputs a measurement result as substrate height data. In a component placing step using an electronic component placing device, a control parameter for controlling a component placing operation of the placing head 32 is updated.
    Type: Application
    Filed: September 17, 2004
    Publication date: September 2, 2010
    Inventors: Kazuhiko Ishihara, Sohei Funaoka, Kanehisa Yokoyama
  • Patent number: 7777002
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: August 17, 2010
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7754646
    Abstract: Highly functionalized, porous organosilica particles and methods of their synthesis are described that employ high amounts of functional silane such as 3-mercaptopropyl trimethoxysilane. Silane particle diameters are controlled from less than 1 ?m to over 100 ?m. The particles have a high surface area due to their advantageous internal structures, which consist of large pores, typically up to 10 ?m that are linked by small channels of typically about 20 nm diameter. Isothiocyanate modified fluorescent dyes can enter and react with thiol groups inside the pores. The invention also provides clear silica shells of controlled thicknesses to protect fluorescent signals and provide an independent parameter for distinguishing particle types based on light scattering off different sized particles. The particles are stable and useful for many purposes, particularly for optical bar coding in combinatorial synthesis of polymers such as nucleic acid, polypeptide, and other synthesized molecules.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: July 13, 2010
    Assignee: Nanomics Biosystems Pty Ltd
    Inventors: Mathias Trau, Angus Johnston
  • Patent number: 7754854
    Abstract: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: July 13, 2010
    Assignee: The Invention Science Fund I, LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
  • Patent number: 7713745
    Abstract: The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: May 11, 2010
    Assignee: Sensors for Medicine and Science, Inc.
    Inventors: Arthur E. Colvin, Jr., Carrie R. Lorenz
  • Patent number: 7645721
    Abstract: A method for coimmobilizing two or more biomolecules on a substrate in a defined ratio is disclosed. The method uses a copolymer conjugated to a number, N, of different types of oligonucleotides. The copolymer can be adsorbed to the surface of the substrate. N types of oligonucleotides complementary to the copolymer-bound oligonucleotides can be conjugated to N types of biomolecules. The types of the copolymer-bound oligonucleotides can be mixed in a defined ratio then adsorbed to the surface. The biomolecule-bound complementary oligonucletides can be conjugated to the copolymer-oligonucleotides to create a substrate with the biomolecules coimmobilized in a defined ratio. The invention also relates to a substrate prepared by the method of the invention.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: January 12, 2010
    Inventors: Karin D. Caldwell, Jennifer A. Neff
  • Publication number: 20090170714
    Abstract: A continuous temperature-gradient incubation apparatus designed to solve the problem of moving of liquid vapor generated on the high-temperature side toward the low-temperature side to thereby cause condensation.
    Type: Application
    Filed: April 13, 2007
    Publication date: July 2, 2009
    Applicant: RESEARCH ORGANIZATION OF INFORMATION AND SYSTEMS
    Inventor: Nobuo Shimamoto
  • Patent number: 7468280
    Abstract: A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided. The methods can advantageously be optimized using combinatorial chemistry, in which a database of combinations of lubricating oil compositions are generated. As market conditions vary and/or product requirements or customer specifications change, conditions suitable for forming desired products can be identified with little or no downtime.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: December 23, 2008
    Assignee: Chevron Oronite Company LLC
    Inventors: Robert H. Wollenberg, Thomas J. Balk
  • Publication number: 20080293596
    Abstract: The present invention relates to systems and methods for generating polymorphs of compounds. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline polymorphs that find use as improved drugs, pigments, explosives, nonlinear optical crystals, solid-state reactive compounds, and other polymorphic materials.
    Type: Application
    Filed: May 15, 2008
    Publication date: November 27, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Adam J. Matzger