With Carboxylic Acid, Ester Or Metal Salt Thereof Patents (Class 514/163)
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Publication number: 20090118243Abstract: The invention relates to methods of treating ophthalmic conditions comprising administering a compound of formula A, a compound of any one of formulae 1-49, a lipoxin compound, or an oxylipin compound.Type: ApplicationFiled: October 10, 2008Publication date: May 7, 2009Applicant: Resolvyx Pharmaceuticals, Inc.Inventor: Per Gjorstrup
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Publication number: 20090062240Abstract: The present invention relates to a novel pharmaceutical combination, containing an inhibitor of platelet aggregation and a fÊbrate, where the inhibitor of platelet aggregation is preferably either aspirin or clopidogreL Such a pharmaceutical combination of an inhibitor of platelet aggregation and a fÊbrate is expected to be useful in the treatment and/or prevention of myocardial infarction (heart attack), cardiac arrest, peripheral vascular disease (including symptomatic carotid artery disease), congestive heart failure, ischemic heart disease, angina pectoris (including unstable angina), sudden cardiac death, unstable angina, as well as cerebrovascular events such as cerebral infarction, cerebral thrombosis, cerebral ischemia and transient ischemic attack, disorders related to bypass operations (angioplasty), fitting of endovascular prostheses and restenosis, and inflammatory disorders, including arthritic conditions such as rheumatoid arthritis and osteoarthritis, as well as asthma or related airway or respType: ApplicationFiled: July 25, 2005Publication date: March 5, 2009Applicant: Fournier Laboratories Ireland LimitedInventors: Alan Edgar, Jean-Louis Junien, Michael Wilkins
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Publication number: 20090053154Abstract: The present invention relates to a composition comprising or (preferably) consisting of 2-ethylhexyl p-methoxycinnamate and 2-ethylhexyl salicylate, the sum of the constituents (a) and (b) ranging from 50 to 100 wt. %, based on the total weight of the composition.Type: ApplicationFiled: August 28, 2006Publication date: February 26, 2009Applicant: SYMRISE GmbH & Co. KGInventor: Roland Langner
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Publication number: 20090036413Abstract: Rationally designed wound care products made entirely of naturally occurring food ingredients that can be standardized and made available for the mass market using good manufacturing practice (GMP) guidelines, optionally, a safe food additive can be added. These products: are safe and effective; have an osmotic pressure compatible with optimal healing; are buffered to maintain optimal pH throughout the healing process; provide a protective barrier from further irritation and insult; control bacteria, viruses and fungi found in the skin and mucosa; nourish wounds; control excessive prolonged inflammation and thereby minimize scarring; minimize allergenic and irritation potential; are easy to use or apply; pass the preservative challenge test required for products intended for multiple use; contain fragrant essential oils to take advantage of the benefits provided by aromatherapy; can be individually optimized based on the diet of an individual or group of people.Type: ApplicationFiled: July 29, 2008Publication date: February 5, 2009Applicant: Bill McAnalleyInventors: Shayne McAnalley, Bill McAnalley, Erik Aguayo
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Publication number: 20080317849Abstract: Methods for improving pain management in a mammal, the methods comprising administering a combination of a strontium-containing compound and a second therapeutically and/or prophylactically active substance selected from the group consisting of analgesic agents, anti-inflammatory agents and palliative agents to the mammal. Pharmaceutical compositions for use in such methods, comprising a strontium-containing compound and a second therapeutically and/or prophylactically active substance selected from the group consisting of analgesic agents, anti-inflammatory agents and palliative agents.Type: ApplicationFiled: June 17, 2005Publication date: December 25, 2008Inventors: Stephan Christgau, Christian Hansen, Henrik Nilsson
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Publication number: 20080312196Abstract: A non-aqueous liquid composition for topical application to warts and other fibroids, papillomas, and other growths for the removal of same is defined by a non-aqueous solution of: (a) at least one keratolytic compound or agent, (b) an adhesive, (c) a dermal regeneration promoter, and (d) a solvent. The composition is applied to the growth or growth site on a daily basis for about at least seven days. The composition can be applied directly to the site or via an impregnated bandage.Type: ApplicationFiled: June 16, 2008Publication date: December 18, 2008Inventor: Carl J. Cohen
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Patent number: 7465460Abstract: A method for the topical treatment of skin aging and acne and the improvement of skin appearance is disclosed. Compositions for use in this method and a kit containing such compositions are also disclosed. In some of the embodiments of the invention, either one, or both, of the acid composition and neutralizing composition useful in the method for the topical treatment of skin aging and acne and the improvement of skin appearance are of low viscosity. The compositions and methods are effective but gentle enough suitable for daily home use by the consumer.Type: GrantFiled: November 24, 2004Date of Patent: December 16, 2008Inventor: Dennis Gross
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Publication number: 20080300217Abstract: The present invention relates to compositions, kits and methods for administration of a first component of fumaric acid ester(s), or a pharmaceutically acceptable salt thereof, and a second component which is a substance that reduces or eliminates flushing.Type: ApplicationFiled: October 9, 2006Publication date: December 4, 2008Applicant: ADITECH PHARMA ABInventor: Henrik Nilsson
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Publication number: 20080269177Abstract: Pesticidal compositions containing a pesticidally acceptable carrier, and a synergistic blend of plant essential oils as a pesticidally active ingredient and optionally a synergist, and methods for using same, are disclosed.Type: ApplicationFiled: April 30, 2008Publication date: October 30, 2008Applicant: ECOSMART TECHNOLOGIES, INC.Inventor: Steven M. BESSETTE
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Publication number: 20080234235Abstract: The present invention provides a method for forming compounds of Formula HO—C(?O)R1—X—R2—X—R1—C(?O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R2 is a linking group.Type: ApplicationFiled: February 6, 2008Publication date: September 25, 2008Inventors: Kathryn E. Uhrich, Robert C. Schmeltzer, Theodore James Anastasiou
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Patent number: 7417037Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.Type: GrantFiled: December 28, 2004Date of Patent: August 26, 2008Assignee: The Board of Regents of the University of OklahomaInventor: Richard F. Harty
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Publication number: 20080161274Abstract: The invention relates to methods of treating or preventing bone loss, as in osteoporosis, metastatic bone disease, or periodontitis, comprising administering a compound of formula A, a compound of any one of formulae 1-49, a lipoxin compound, or an oxylipin compound.Type: ApplicationFiled: October 26, 2007Publication date: July 3, 2008Applicant: Resolvyx Pharmaceuticals, Inc.Inventors: Per Gjorstrup, Matthew James Nichols
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Publication number: 20080146529Abstract: The present invention relates to methods of peeling skin using certain salicylic acid derivatives, to chemical skin peel compositions containing these certain salicylic acid derivatives in a carrier, preferably a dermatologically acceptable carrier, to methods of making these compositions, and methods of applying this certain compound and/or composition to skin to be peeled.Type: ApplicationFiled: January 31, 2008Publication date: June 19, 2008Applicant: L'OREAL S.A.Inventors: Isabelle Hansenne, Hani Fares, Marc Cornell, Sidney P. Foltis
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Publication number: 20080139517Abstract: Therapeutic methods for treatment of age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer's disease (AD), cerebrovascular dementia (CVD), and related neurodegenerative conditions by administering an agent capable of inhibiting cell cycle progression, comprising administering one or more agents that are capable of inhibiting neuronal cell cycle progression at either an early cell cycle phase or generally, either alone or in combination with one or more agents capable of reducing mitogenic stimulation.Type: ApplicationFiled: September 7, 2007Publication date: June 12, 2008Inventor: Barry Reisberg
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Patent number: 7326809Abstract: The present invention provides L-arginine salts of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these L-arginine salts of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of an inflammatory condition of the GI tract such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).Type: GrantFiled: May 27, 2005Date of Patent: February 5, 2008Assignee: Antibe Therapeutics Inc.Inventors: John L. Wallace, Giuseppe Cirino, Anna Sparatore
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Patent number: 7323452Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: December 20, 2004Date of Patent: January 29, 2008Assignee: Wardan, L.L.C.Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
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Publication number: 20070218149Abstract: The present invention relates to treatment of joint or muscle pain and, in particular, combinations of ingredients for such treatment. The invention provides a composition, which includes the following components: emu oil, a salicylate analgesic agent, devil's claw, and ginger. The components are present in the composition in an amount sufficient to alleviate joint or muscle pain in a mammal in need thereof. A composition having essentially emu oil, a salicylate analgesic agent, devil's claw and ginger is also provided. The invention further provides a method for alleviating joint or muscle pain in a mammal. The method includes administering topically to the mammal the composition of the present invention.Type: ApplicationFiled: March 14, 2007Publication date: September 20, 2007Inventor: Richard H. Blau
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Patent number: 7189406Abstract: A two-step method for the topical treatment of skin aging and acne and the improvement of skin appearance is disclosed. Compositions for use in this method and a kit containing such compositions are also disclosed. The compositions and methods are effective but gentle enough suitable for daily home use by the consumer.Type: GrantFiled: June 23, 1999Date of Patent: March 13, 2007Inventor: Dennis Gross
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Patent number: 7147872Abstract: Environmentally friendly processes for prevention of qualitative deterioration and quantitative loss of plant matter and foodstuffs, during all stages of storage and handling, including pre- and post-harvest, pre- and post-planting, distribution and marketing involves the use of H2O2 compositions including Ag and at least one of Cu and Zn ions. The processes can also be used to prevent sprouting and rooting, and to promote fecundity of certain plant matter, and can also be used to eliminate or reduce quantities of harmful organisms and substances from soil, other growth media and substrates, equipment, materials water, workspaces and surfaces.Type: GrantFiled: August 12, 2005Date of Patent: December 12, 2006Assignee: Pimi Marion Holdings, Ltd.Inventors: Nimrod Ben-Yehuda, Eliahu Margalit
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Patent number: 7144879Abstract: The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of microbial infections (viral, bacterial and mycotic), tumor, pre-cancerous and proliferative pathologies and/or in the diagnosis, as well as for blood and blood derivatives sterilizationType: GrantFiled: June 11, 2001Date of Patent: December 5, 2006Assignee: L. Molteni & C. Dei FratelliInventors: Gabrio Roncucci, Lia Fantetti, Maria Paola De Filippis, Donata Dei, Giulio Jori
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Patent number: 7135197Abstract: The present invention provides a pharmaceutical composition comprising at least one pharmaceutically acceptable bismuth-containing compound, at least one pharmaceutically acceptable non-clay-derived suspending agent, and water. The suspension exhibits reduced upward pH drift by comparison with an otherwise similar suspension which comprises a clay-derived suspending agent. Such compositions are useful in the prevention and treatment of gastrointestinal diseases and/or disorders.Type: GrantFiled: February 3, 2003Date of Patent: November 14, 2006Assignee: Pharmacia CorporationInventors: Lorraine E. Pena, Dennis L. Huczek
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Patent number: 7094431Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide; (b) calcium channel blocker, and (c) fat-soluble vitamins admixed with antibacterial and antifungal agents. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products and administered orally or topically.Type: GrantFiled: September 30, 2003Date of Patent: August 22, 2006Inventor: Mickey L. Peshoff
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Patent number: 7056903Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.Type: GrantFiled: May 9, 2003Date of Patent: June 6, 2006Assignee: Syntex (U.S.A.) LLCInventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie, Jr., Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
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Patent number: 7029706Abstract: The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and silica.Type: GrantFiled: November 21, 2002Date of Patent: April 18, 2006Inventor: Carlos Alberto Marrodan
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Patent number: 7030147Abstract: Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.Type: GrantFiled: March 18, 2002Date of Patent: April 18, 2006Assignee: Novartis AGInventors: John David Rothermel, Horst F. Schran, Diane Greeley, TianLing Chen
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Patent number: 7005517Abstract: The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance Imaging), diagnostic X-ray imaging and computed tomography(CT). The present invention also provides contrast agents for imaging, comprising the new paramagnetic metal-phthalocyanine complexes. The new contrast agents of the present invention show high imaging enhancement effects at lower concentration and are safer than the previously reported contrast agents.Type: GrantFiled: January 4, 2002Date of Patent: February 28, 2006Inventors: Sung-Young Lee, Kyo-Im Koo
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Patent number: 6964782Abstract: Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable towelette forms of H2O2. Optional ingredients of topical pain relievers and skin protectants are also disclosed, as are their methods of use.Type: GrantFiled: July 7, 2003Date of Patent: November 15, 2005Assignee: Tec Labs, Inc.Inventors: Robert Lee Smith, Steven Dale Smith, Wendy S. Langley, John Mark Christensen, Vernon W. Smith
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Patent number: 6855341Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.Type: GrantFiled: November 4, 2002Date of Patent: February 15, 2005Inventor: Jeffrey B. Smith
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Patent number: 6846837Abstract: Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.Type: GrantFiled: June 21, 2002Date of Patent: January 25, 2005Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
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Patent number: 6833362Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: June 7, 2001Date of Patent: December 21, 2004Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
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Patent number: 6825184Abstract: Disclosed are compounds of the formulas (I) & (II) shown below which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds. wherein G, X, A and Q are described herein.Type: GrantFiled: October 11, 2002Date of Patent: November 30, 2004Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Pier Francesco Cirillo, Abdelhakim Hammach, John R. Regan
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Patent number: 6783767Abstract: A powder composition which reacts in water to form in situ peroxycarboxylic acids at an anti-microbially effective concentration. Importantly, its utility is both for topical anti-microbial application and for effective low temperature disinfection/sterilization of instruments. It comprises the combination of a perborate, one or more novel acyl and/or aroyl donors, a buffering system which allows the pH to arise to about 9 for rapid formation of the peroxycarboxylic acids and then drop to about 7.5 for sustained stability and microbial kill. It preferably includes a surfactant facilitating antimicrobial efficacy, as well as other minors.Type: GrantFiled: February 8, 2002Date of Patent: August 31, 2004Assignee: Healthpoint, Ltd.Inventors: Braham Shroot, Lawton A. Seal, James R. Hunt, Jonathan Sterling, Kathy Bolsen, Penny L. Sitka
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Patent number: 6730329Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: February 26, 2002Date of Patent: May 4, 2004Inventor: Jeffrey B. Smith
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Patent number: 6669903Abstract: Sterilization or bacteriostasis is carried out using cellulose acetate. The cellulose acetate exhibits an excellent antibacterial property with respect to fungi such as Trichophyton, etc. and bacteria such as, for example, enteropathogenic Escherichia coli O-157 or Methicillin tolerance Staphylococcus aureus. The cellulose acetate may be mixed with resin such as, for example, polyethylene or polypropylene, and this mixture may be used to produce fibers. Then, a textile product may be manufactured using the fibers thus produced. The cellulose acetate may be dissolved in a mixed solvent of ethyl acetate, ethanol, and methyl alcohol, so that a coating material is prepared. This coating material is applied to an object to be sterilized and then is dried to form a coating film made of cellulose acetate. This coating film exhibits the antibacterial property.Type: GrantFiled: June 1, 2001Date of Patent: December 30, 2003Assignees: Yokoyama Co., Ltd.Inventor: Michio Hayashi
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Publication number: 20030166621Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.Type: ApplicationFiled: February 21, 2003Publication date: September 4, 2003Inventor: Werner Kreutz
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Patent number: 6511968Abstract: The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis, thromboembolism, thrombotic occlusion and reocclusion, restenosis, transient ischemic attack, and first or subsequent thrombotic stroke, in a patient, comprising administering to the patient a therapeutically effective amount of an antiplatelet agent in combination with a therapeutically effective amount of a COX-2 inhibitor. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a COX-2 inhibitor, or a pharmaceutically acceptable salt thereof, and an antiplatelet agent, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 23, 2000Date of Patent: January 28, 2003Assignee: Merck & Co., Inc.Inventor: Steven A. Nichtberger
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Publication number: 20030013688Abstract: A synergistic combination of pravastatin and aspirin is provided which is formed of 40 mg pravastatin and 81 mg or higher of aspirin, preferably 81 mg aspirin or 325 mg of aspirin. A method for preventing, inhibiting or reducing risk of onset of cardiovascular events or cerebrovascular events employing such synergistic combination is also provided.Type: ApplicationFiled: April 23, 2002Publication date: January 16, 2003Inventors: Rene Belder, Kannan Natarajan
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Patent number: 6475526Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: June 5, 2001Date of Patent: November 5, 2002Inventor: Jeffrey B. Smith
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Patent number: 6451356Abstract: The present invention provides a pharmaceutical composition for treating bacterial infections in patients comprising an effective amount of 3.5-dihydroxy-4-pent-4′-enoyl-1′-oxymethylbenzoic acid (Oenostacin) isolated from Oenothera biennis.Type: GrantFiled: February 22, 2002Date of Patent: September 17, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Yogendra Nath Shukla, Tiruppadiripuliyur Ranganathan Santha Kumar, Anil Srivastava, Suman Preet Singh Khanuja, Vivek Kumar Gupta, Sushil Kumar
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Patent number: 6440406Abstract: The present invention provides a composition for attracting scarabs. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating scarabs, and/or protecting plants susceptible to scarab damage.Type: GrantFiled: June 12, 2000Date of Patent: August 27, 2002Assignees: The United States of America as represented by the Secretary of Agriculture, The Texas A&M University SystemInventors: Juan D. Lopez, Jr., Robert L. Crocker, Ted N. Shaver
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Patent number: 6251887Abstract: The invention relates to 17&bgr;-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives having general formula (I), wherein R1 is (H,OR), (H,OSO3H) or NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is independently hydrogen or (C1-6)alyl; n is 0, 1, or 2; X is O, S, S(O) or S(O)2; m is 0 or 1; each of R4, R5 and R6 is independently hydrogen, hydroxy, (C1-4)alkoxy, halogen, NR7R8 or (C1-4)alkyl, optionally substituted by hydroxy, alkoxy, halogen or oxo; each of R7 and R8 is independently hydrogen or (C1-4)alkyl, and wherein the dotted lines indicate a &Dgr;7 or a &Dgr;8 double bond, or a pair of conjugated double bonds selected from &Dgr;7,14, &Dgr;8,14 and &Dgr;6,8(14); or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis regulating activity and can be used for the control of fertility.Type: GrantFiled: June 16, 2000Date of Patent: June 26, 2001Assignee: Akzo Nobel N.V.Inventors: Christian Heijmans, Jaap van der Louw
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Patent number: 6232341Abstract: The present invention provides a topical pharmaceutical composition for wound healing, which comprises (a) borneol and (b) bismuth subgallate in effective amounts. The topical pharmaceutical composition is capable of enhancing wound healing with minor irritations to injured skin, and preventing formation of scars or granulation tissues so as to help regenerate the skin with normal tenderness and appearances.Type: GrantFiled: October 5, 1998Date of Patent: May 15, 2001Assignee: Hedonist Biochemical TechnologInventors: James J. T. Chen, Black J. B. Chen
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Patent number: 6201022Abstract: Methods are disclosed for treating neurotransmitter-mediated pain syndromes such as fibromyalgia. Such methods include topically administering an effective amount of a composition containing an omega fatty acid in combination with a carrier or diluent. The composition may also contain a cyclo-oxygenase inhibitor and other optional components, such as vitamins A, E and/or C.Type: GrantFiled: March 27, 1997Date of Patent: March 13, 2001Assignee: MyoRx, Inc.Inventors: Philip J. Mease, Barry I. Bockow, Marc D. Erlitz
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Patent number: 6127352Abstract: Compositions for the relief of pain containing acetyl salicylic acid or acetaminophen as a peripherally acting analgesic and codeine as a centrally acting agent.Type: GrantFiled: September 22, 1992Date of Patent: October 3, 2000Inventor: Jose R. Uribe
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Patent number: 6124275Abstract: The invention is directed to a method for controlling a pest population using a composition comprising a benzyl ester of an aromatic acid or aliphatic acid or a salicylate. Methods and compositions for controlling a pest population are provided. The compositions comprise a benzyl ester of an aromatic acid or aliphatic acid or a salicylate. The composition can include at least one fatty-acid ester to increase the pesticidal activity. The subject method controls the population of pests such as plant pests or pests infesting a mammal by contacting the pests with the composition. The subject method reduces the environmental and health hazards in pest control by minimizing the toxicity of the subject composition.Type: GrantFiled: April 29, 1999Date of Patent: September 26, 2000Assignee: Summus Group, Ltd.Inventor: Ralph W. Emerson
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Patent number: 6110906Abstract: Methods for treating sex steroid-dependent diseases by inhibiting sex steroid activity include administration of novel compounds which include an androgenic nucleus substituted at a ring carbon with at least one substituent specified herein. Such compounds may function by inhibiting sex steroid synthesis (both estrogen and androgen synthesis) and/or by antagonistically blocking androgen receptors.Type: GrantFiled: July 21, 1994Date of Patent: August 29, 2000Assignee: Endorecherche, Inc.Inventors: Fernand Labrie, Yves Merand
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Patent number: 6074634Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.Type: GrantFiled: October 5, 1998Date of Patent: June 13, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
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Patent number: 5972987Abstract: A method for removing lice eggs from the hair of an infested human or animal using a nit-visualizing composition. The composition involves the use of certain dyes which have an affinity to the surface of nits, to thereby enable a second individual to more easily see and remove the eggs during a combing or other removal process. To effectuate this purpose, a colored material is dispersed within a water- or alcohol-based solvent and, in one embodiment, a liquefied propellant as well. The composition is applied to the hair of the infested human or animal, and then removed after drying by a process of brushing or washing. However, the colored material which adsorbs to the chitinous exoskeleton and binding cement of the lice eggs remains on the nits, thereby facilitating visual identification and removal of the lice eggs from hair.Type: GrantFiled: March 16, 1999Date of Patent: October 26, 1999Assignee: Lori Fox ReidInventors: Lori Fox Reid, Robert D. Kross
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Patent number: 5948443Abstract: The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process.Type: GrantFiled: February 21, 1997Date of Patent: September 7, 1999Assignee: Medical Doctor's Research Institute, Inc.Inventors: Patricia A. Riley, George Christakis
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Patent number: 5919776Abstract: The present invention is directed to aminoquinolines of Formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.Type: GrantFiled: December 18, 1997Date of Patent: July 6, 1999Assignee: Merck & Co., Inc.Inventors: William K. Hagmann, Martin S. Springer