With Carboxylic Acid, Ester Or Metal Salt Thereof Patents (Class 514/163)
  • Publication number: 20080317849
    Abstract: Methods for improving pain management in a mammal, the methods comprising administering a combination of a strontium-containing compound and a second therapeutically and/or prophylactically active substance selected from the group consisting of analgesic agents, anti-inflammatory agents and palliative agents to the mammal. Pharmaceutical compositions for use in such methods, comprising a strontium-containing compound and a second therapeutically and/or prophylactically active substance selected from the group consisting of analgesic agents, anti-inflammatory agents and palliative agents.
    Type: Application
    Filed: June 17, 2005
    Publication date: December 25, 2008
    Inventors: Stephan Christgau, Christian Hansen, Henrik Nilsson
  • Publication number: 20080312196
    Abstract: A non-aqueous liquid composition for topical application to warts and other fibroids, papillomas, and other growths for the removal of same is defined by a non-aqueous solution of: (a) at least one keratolytic compound or agent, (b) an adhesive, (c) a dermal regeneration promoter, and (d) a solvent. The composition is applied to the growth or growth site on a daily basis for about at least seven days. The composition can be applied directly to the site or via an impregnated bandage.
    Type: Application
    Filed: June 16, 2008
    Publication date: December 18, 2008
    Inventor: Carl J. Cohen
  • Patent number: 7465460
    Abstract: A method for the topical treatment of skin aging and acne and the improvement of skin appearance is disclosed. Compositions for use in this method and a kit containing such compositions are also disclosed. In some of the embodiments of the invention, either one, or both, of the acid composition and neutralizing composition useful in the method for the topical treatment of skin aging and acne and the improvement of skin appearance are of low viscosity. The compositions and methods are effective but gentle enough suitable for daily home use by the consumer.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: December 16, 2008
    Inventor: Dennis Gross
  • Publication number: 20080300217
    Abstract: The present invention relates to compositions, kits and methods for administration of a first component of fumaric acid ester(s), or a pharmaceutically acceptable salt thereof, and a second component which is a substance that reduces or eliminates flushing.
    Type: Application
    Filed: October 9, 2006
    Publication date: December 4, 2008
    Applicant: ADITECH PHARMA AB
    Inventor: Henrik Nilsson
  • Publication number: 20080269177
    Abstract: Pesticidal compositions containing a pesticidally acceptable carrier, and a synergistic blend of plant essential oils as a pesticidally active ingredient and optionally a synergist, and methods for using same, are disclosed.
    Type: Application
    Filed: April 30, 2008
    Publication date: October 30, 2008
    Applicant: ECOSMART TECHNOLOGIES, INC.
    Inventor: Steven M. BESSETTE
  • Publication number: 20080234235
    Abstract: The present invention provides a method for forming compounds of Formula HO—C(?O)R1—X—R2—X—R1—C(?O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeutically active compounds. In the compounds of the invention, each R1 is group that will provide the therapeutically active compound upon hydrolysis of the polymer; each X is independently an ester linkage or an amide linkage; and R2 is a linking group.
    Type: Application
    Filed: February 6, 2008
    Publication date: September 25, 2008
    Inventors: Kathryn E. Uhrich, Robert C. Schmeltzer, Theodore James Anastasiou
  • Patent number: 7417037
    Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: August 26, 2008
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Richard F. Harty
  • Publication number: 20080161274
    Abstract: The invention relates to methods of treating or preventing bone loss, as in osteoporosis, metastatic bone disease, or periodontitis, comprising administering a compound of formula A, a compound of any one of formulae 1-49, a lipoxin compound, or an oxylipin compound.
    Type: Application
    Filed: October 26, 2007
    Publication date: July 3, 2008
    Applicant: Resolvyx Pharmaceuticals, Inc.
    Inventors: Per Gjorstrup, Matthew James Nichols
  • Publication number: 20080146529
    Abstract: The present invention relates to methods of peeling skin using certain salicylic acid derivatives, to chemical skin peel compositions containing these certain salicylic acid derivatives in a carrier, preferably a dermatologically acceptable carrier, to methods of making these compositions, and methods of applying this certain compound and/or composition to skin to be peeled.
    Type: Application
    Filed: January 31, 2008
    Publication date: June 19, 2008
    Applicant: L'OREAL S.A.
    Inventors: Isabelle Hansenne, Hani Fares, Marc Cornell, Sidney P. Foltis
  • Publication number: 20080139517
    Abstract: Therapeutic methods for treatment of age associated memory impairment (AAMI), mild cognitive impairment (MCI), Alzheimer's disease (AD), cerebrovascular dementia (CVD), and related neurodegenerative conditions by administering an agent capable of inhibiting cell cycle progression, comprising administering one or more agents that are capable of inhibiting neuronal cell cycle progression at either an early cell cycle phase or generally, either alone or in combination with one or more agents capable of reducing mitogenic stimulation.
    Type: Application
    Filed: September 7, 2007
    Publication date: June 12, 2008
    Inventor: Barry Reisberg
  • Patent number: 7326809
    Abstract: The present invention provides L-arginine salts of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these L-arginine salts of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of an inflammatory condition of the GI tract such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: February 5, 2008
    Assignee: Antibe Therapeutics Inc.
    Inventors: John L. Wallace, Giuseppe Cirino, Anna Sparatore
  • Patent number: 7323452
    Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 29, 2008
    Assignee: Wardan, L.L.C.
    Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
  • Publication number: 20070218149
    Abstract: The present invention relates to treatment of joint or muscle pain and, in particular, combinations of ingredients for such treatment. The invention provides a composition, which includes the following components: emu oil, a salicylate analgesic agent, devil's claw, and ginger. The components are present in the composition in an amount sufficient to alleviate joint or muscle pain in a mammal in need thereof. A composition having essentially emu oil, a salicylate analgesic agent, devil's claw and ginger is also provided. The invention further provides a method for alleviating joint or muscle pain in a mammal. The method includes administering topically to the mammal the composition of the present invention.
    Type: Application
    Filed: March 14, 2007
    Publication date: September 20, 2007
    Inventor: Richard H. Blau
  • Patent number: 7189406
    Abstract: A two-step method for the topical treatment of skin aging and acne and the improvement of skin appearance is disclosed. Compositions for use in this method and a kit containing such compositions are also disclosed. The compositions and methods are effective but gentle enough suitable for daily home use by the consumer.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: March 13, 2007
    Inventor: Dennis Gross
  • Patent number: 7147872
    Abstract: Environmentally friendly processes for prevention of qualitative deterioration and quantitative loss of plant matter and foodstuffs, during all stages of storage and handling, including pre- and post-harvest, pre- and post-planting, distribution and marketing involves the use of H2O2 compositions including Ag and at least one of Cu and Zn ions. The processes can also be used to prevent sprouting and rooting, and to promote fecundity of certain plant matter, and can also be used to eliminate or reduce quantities of harmful organisms and substances from soil, other growth media and substrates, equipment, materials water, workspaces and surfaces.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: December 12, 2006
    Assignee: Pimi Marion Holdings, Ltd.
    Inventors: Nimrod Ben-Yehuda, Eliahu Margalit
  • Patent number: 7144879
    Abstract: The present invention is directed to metal-phthalocyanines of general formula (I) to the corresponding conjugates, the processes for their preparation and use in the photodynamic therapy of microbial infections (viral, bacterial and mycotic), tumor, pre-cancerous and proliferative pathologies and/or in the diagnosis, as well as for blood and blood derivatives sterilization
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: December 5, 2006
    Assignee: L. Molteni & C. Dei Fratelli
    Inventors: Gabrio Roncucci, Lia Fantetti, Maria Paola De Filippis, Donata Dei, Giulio Jori
  • Patent number: 7135197
    Abstract: The present invention provides a pharmaceutical composition comprising at least one pharmaceutically acceptable bismuth-containing compound, at least one pharmaceutically acceptable non-clay-derived suspending agent, and water. The suspension exhibits reduced upward pH drift by comparison with an otherwise similar suspension which comprises a clay-derived suspending agent. Such compositions are useful in the prevention and treatment of gastrointestinal diseases and/or disorders.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: November 14, 2006
    Assignee: Pharmacia Corporation
    Inventors: Lorraine E. Pena, Dennis L. Huczek
  • Patent number: 7094431
    Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide; (b) calcium channel blocker, and (c) fat-soluble vitamins admixed with antibacterial and antifungal agents. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products and administered orally or topically.
    Type: Grant
    Filed: September 30, 2003
    Date of Patent: August 22, 2006
    Inventor: Mickey L. Peshoff
  • Patent number: 7056903
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: June 6, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie, Jr., Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
  • Patent number: 7030147
    Abstract: Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: April 18, 2006
    Assignee: Novartis AG
    Inventors: John David Rothermel, Horst F. Schran, Diane Greeley, TianLing Chen
  • Patent number: 7029706
    Abstract: The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and silica.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: April 18, 2006
    Inventor: Carlos Alberto Marrodan
  • Patent number: 7005517
    Abstract: The present invention provides a novel paramagnetic metal-phthalocyanine complexes and pharmaceutically acceptable salts thereof, which are useful as contrast agents for MRI(Magnetic Resonance Imaging), diagnostic X-ray imaging and computed tomography(CT). The present invention also provides contrast agents for imaging, comprising the new paramagnetic metal-phthalocyanine complexes. The new contrast agents of the present invention show high imaging enhancement effects at lower concentration and are safer than the previously reported contrast agents.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: February 28, 2006
    Inventors: Sung-Young Lee, Kyo-Im Koo
  • Patent number: 6964782
    Abstract: Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable towelette forms of H2O2. Optional ingredients of topical pain relievers and skin protectants are also disclosed, as are their methods of use.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: November 15, 2005
    Assignee: Tec Labs, Inc.
    Inventors: Robert Lee Smith, Steven Dale Smith, Wendy S. Langley, John Mark Christensen, Vernon W. Smith
  • Patent number: 6855341
    Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: February 15, 2005
    Inventor: Jeffrey B. Smith
  • Patent number: 6846837
    Abstract: Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: January 25, 2005
    Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu
  • Patent number: 6833362
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 21, 2004
    Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
  • Patent number: 6825184
    Abstract: Disclosed are compounds of the formulas (I) & (II) shown below which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds. wherein G, X, A and Q are described herein.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: November 30, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier Francesco Cirillo, Abdelhakim Hammach, John R. Regan
  • Patent number: 6783767
    Abstract: A powder composition which reacts in water to form in situ peroxycarboxylic acids at an anti-microbially effective concentration. Importantly, its utility is both for topical anti-microbial application and for effective low temperature disinfection/sterilization of instruments. It comprises the combination of a perborate, one or more novel acyl and/or aroyl donors, a buffering system which allows the pH to arise to about 9 for rapid formation of the peroxycarboxylic acids and then drop to about 7.5 for sustained stability and microbial kill. It preferably includes a surfactant facilitating antimicrobial efficacy, as well as other minors.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: August 31, 2004
    Assignee: Healthpoint, Ltd.
    Inventors: Braham Shroot, Lawton A. Seal, James R. Hunt, Jonathan Sterling, Kathy Bolsen, Penny L. Sitka
  • Patent number: 6730329
    Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: May 4, 2004
    Inventor: Jeffrey B. Smith
  • Patent number: 6669903
    Abstract: Sterilization or bacteriostasis is carried out using cellulose acetate. The cellulose acetate exhibits an excellent antibacterial property with respect to fungi such as Trichophyton, etc. and bacteria such as, for example, enteropathogenic Escherichia coli O-157 or Methicillin tolerance Staphylococcus aureus. The cellulose acetate may be mixed with resin such as, for example, polyethylene or polypropylene, and this mixture may be used to produce fibers. Then, a textile product may be manufactured using the fibers thus produced. The cellulose acetate may be dissolved in a mixed solvent of ethyl acetate, ethanol, and methyl alcohol, so that a coating material is prepared. This coating material is applied to an object to be sterilized and then is dried to form a coating film made of cellulose acetate. This coating film exhibits the antibacterial property.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: December 30, 2003
    Assignees: Yokoyama Co., Ltd.
    Inventor: Michio Hayashi
  • Publication number: 20030166621
    Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.
    Type: Application
    Filed: February 21, 2003
    Publication date: September 4, 2003
    Inventor: Werner Kreutz
  • Patent number: 6511968
    Abstract: The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis, thromboembolism, thrombotic occlusion and reocclusion, restenosis, transient ischemic attack, and first or subsequent thrombotic stroke, in a patient, comprising administering to the patient a therapeutically effective amount of an antiplatelet agent in combination with a therapeutically effective amount of a COX-2 inhibitor. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a COX-2 inhibitor, or a pharmaceutically acceptable salt thereof, and an antiplatelet agent, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: January 28, 2003
    Assignee: Merck & Co., Inc.
    Inventor: Steven A. Nichtberger
  • Publication number: 20030013688
    Abstract: A synergistic combination of pravastatin and aspirin is provided which is formed of 40 mg pravastatin and 81 mg or higher of aspirin, preferably 81 mg aspirin or 325 mg of aspirin. A method for preventing, inhibiting or reducing risk of onset of cardiovascular events or cerebrovascular events employing such synergistic combination is also provided.
    Type: Application
    Filed: April 23, 2002
    Publication date: January 16, 2003
    Inventors: Rene Belder, Kannan Natarajan
  • Patent number: 6475526
    Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: November 5, 2002
    Inventor: Jeffrey B. Smith
  • Patent number: 6451356
    Abstract: The present invention provides a pharmaceutical composition for treating bacterial infections in patients comprising an effective amount of 3.5-dihydroxy-4-pent-4′-enoyl-1′-oxymethylbenzoic acid (Oenostacin) isolated from Oenothera biennis.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: September 17, 2002
    Assignee: Council of Scientific and Industrial Research
    Inventors: Yogendra Nath Shukla, Tiruppadiripuliyur Ranganathan Santha Kumar, Anil Srivastava, Suman Preet Singh Khanuja, Vivek Kumar Gupta, Sushil Kumar
  • Patent number: 6440406
    Abstract: The present invention provides a composition for attracting scarabs. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating scarabs, and/or protecting plants susceptible to scarab damage.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 27, 2002
    Assignees: The United States of America as represented by the Secretary of Agriculture, The Texas A&M University System
    Inventors: Juan D. Lopez, Jr., Robert L. Crocker, Ted N. Shaver
  • Patent number: 6251887
    Abstract: The invention relates to 17&bgr;-aryl(arylmethyl)oxy(thio)alkyl-androstane derivatives having general formula (I), wherein R1 is (H,OR), (H,OSO3H) or NOR; with R being H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is independently hydrogen or (C1-6)alyl; n is 0, 1, or 2; X is O, S, S(O) or S(O)2; m is 0 or 1; each of R4, R5 and R6 is independently hydrogen, hydroxy, (C1-4)alkoxy, halogen, NR7R8 or (C1-4)alkyl, optionally substituted by hydroxy, alkoxy, halogen or oxo; each of R7 and R8 is independently hydrogen or (C1-4)alkyl, and wherein the dotted lines indicate a &Dgr;7 or a &Dgr;8 double bond, or a pair of conjugated double bonds selected from &Dgr;7,14, &Dgr;8,14 and &Dgr;6,8(14); or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis regulating activity and can be used for the control of fertility.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: June 26, 2001
    Assignee: Akzo Nobel N.V.
    Inventors: Christian Heijmans, Jaap van der Louw
  • Patent number: 6232341
    Abstract: The present invention provides a topical pharmaceutical composition for wound healing, which comprises (a) borneol and (b) bismuth subgallate in effective amounts. The topical pharmaceutical composition is capable of enhancing wound healing with minor irritations to injured skin, and preventing formation of scars or granulation tissues so as to help regenerate the skin with normal tenderness and appearances.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: May 15, 2001
    Assignee: Hedonist Biochemical Technolog
    Inventors: James J. T. Chen, Black J. B. Chen
  • Patent number: 6201022
    Abstract: Methods are disclosed for treating neurotransmitter-mediated pain syndromes such as fibromyalgia. Such methods include topically administering an effective amount of a composition containing an omega fatty acid in combination with a carrier or diluent. The composition may also contain a cyclo-oxygenase inhibitor and other optional components, such as vitamins A, E and/or C.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: March 13, 2001
    Assignee: MyoRx, Inc.
    Inventors: Philip J. Mease, Barry I. Bockow, Marc D. Erlitz
  • Patent number: 6127352
    Abstract: Compositions for the relief of pain containing acetyl salicylic acid or acetaminophen as a peripherally acting analgesic and codeine as a centrally acting agent.
    Type: Grant
    Filed: September 22, 1992
    Date of Patent: October 3, 2000
    Inventor: Jose R. Uribe
  • Patent number: 6124275
    Abstract: The invention is directed to a method for controlling a pest population using a composition comprising a benzyl ester of an aromatic acid or aliphatic acid or a salicylate. Methods and compositions for controlling a pest population are provided. The compositions comprise a benzyl ester of an aromatic acid or aliphatic acid or a salicylate. The composition can include at least one fatty-acid ester to increase the pesticidal activity. The subject method controls the population of pests such as plant pests or pests infesting a mammal by contacting the pests with the composition. The subject method reduces the environmental and health hazards in pest control by minimizing the toxicity of the subject composition.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: September 26, 2000
    Assignee: Summus Group, Ltd.
    Inventor: Ralph W. Emerson
  • Patent number: 6110906
    Abstract: Methods for treating sex steroid-dependent diseases by inhibiting sex steroid activity include administration of novel compounds which include an androgenic nucleus substituted at a ring carbon with at least one substituent specified herein. Such compounds may function by inhibiting sex steroid synthesis (both estrogen and androgen synthesis) and/or by antagonistically blocking androgen receptors.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: August 29, 2000
    Assignee: Endorecherche, Inc.
    Inventors: Fernand Labrie, Yves Merand
  • Patent number: 6074634
    Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: June 13, 2000
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
  • Patent number: 5972987
    Abstract: A method for removing lice eggs from the hair of an infested human or animal using a nit-visualizing composition. The composition involves the use of certain dyes which have an affinity to the surface of nits, to thereby enable a second individual to more easily see and remove the eggs during a combing or other removal process. To effectuate this purpose, a colored material is dispersed within a water- or alcohol-based solvent and, in one embodiment, a liquefied propellant as well. The composition is applied to the hair of the infested human or animal, and then removed after drying by a process of brushing or washing. However, the colored material which adsorbs to the chitinous exoskeleton and binding cement of the lice eggs remains on the nits, thereby facilitating visual identification and removal of the lice eggs from hair.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: October 26, 1999
    Assignee: Lori Fox Reid
    Inventors: Lori Fox Reid, Robert D. Kross
  • Patent number: 5948443
    Abstract: The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American population. More specifically, the present invention concerns a total modular system of multivitamin and mineral supplementation composed of 7 distinct modules for improving public health by insuring adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to, for example, lifestyle factors and common inadequate dietary patterns. A module, as used herein throughout, is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. The formulations of the present invention which, when combined in one capsule or tablet or as separate modules, exert a joint and enhancing effect on the major pathogenetic factors involved in the atherosclerotic process.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: September 7, 1999
    Assignee: Medical Doctor's Research Institute, Inc.
    Inventors: Patricia A. Riley, George Christakis
  • Patent number: 5919776
    Abstract: The present invention is directed to aminoquinolines of Formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: July 6, 1999
    Assignee: Merck & Co., Inc.
    Inventors: William K. Hagmann, Martin S. Springer
  • Patent number: 5891451
    Abstract: A method and composition is provided for treating skin conditions including those arising from dermatologic disorders, chronoaging and environmental abuse. Non-ring esterified C.sub.11 -C.sub.30 alkyl or alkenyl esters of salicylic acid are used as the active component in combination with a pharmaceutically acceptable carrier. Most preferred is tridecyl salicylate.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: April 6, 1999
    Assignee: Elizabeth Arden Company, Division of Conopco, Inc.
    Inventors: Angel Augusto Guerrero, Peter Ladislaus Dorogi, Thomas Charles Klepacky
  • Patent number: 5827543
    Abstract: The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa comprising administering to the subject bismuth and one or more antimicrobials. The subject invention also encompasses compositions comprising bismuth and one or more antimicrobials for the prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa.
    Type: Grant
    Filed: December 7, 1995
    Date of Patent: October 27, 1998
    Assignee: The Procter & Gamble Company
    Inventor: Jamesina Anne Fitzgerald
  • Patent number: 5716648
    Abstract: Compositions for use in the regulation of subnormal pH values in intestinal tract and for treatment of bowel diseases. The compositions comprise a coating and a substantially insoluble alkaline material confined within said coating, the composition being adapted so as to ensure the availability of an amount of said pH regulating alkaline material in the lumen of the gastrointestinal tract exhibiting subnormal pH values. E.g. In the proximal small intestine, the mid small intestine, the distal small intestine, the caecum, the ascending colon, the transverse colon, the descending colon, the sigmoid colon and/or the rectum. The compositions may also comprise a medicament for treatment of bowel disease, e.g. 5-aminosalicylic acid for the treatment of Crohn's disease and colitis ulcerosa. The administration may be oral composition or enemas or suppositories.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: February 10, 1998
    Assignee: Farmaceutisk Laboratorium Ferring A/S
    Inventors: S.o slashed.ren Halskov, Svenn Kluver Jepsen
  • Patent number: 5674858
    Abstract: The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders.Pharmaceutical compositions containing both (i) and (ii) and methods for the preparation of pharmaceutical compositions containing (i) and (ii) are also described.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 7, 1997
    Assignee: Glaxo Group Limited
    Inventor: Andrew Alexander McColm