Chalcogen Bonded Directly To The 2-and 6- Positions Of The Purine Ring System (e.g., Theophylline, Etc.) Patents (Class 514/263.34)
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Publication number: 20140256750Abstract: The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a coughing condition with such compositions.Type: ApplicationFiled: May 24, 2014Publication date: September 11, 2014Applicant: Biocopea LimitedInventors: John Brew, Robin Mark Bannister
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Publication number: 20140256749Abstract: One aspect of the invention relates to caffeine-containing compositions comprising caffeine and one or more esters. The caffeine-containing compositions disclosed herein can be used for effective transdermal delivery of caffeine to a subject. Another aspect of the invention relates to applications and preparations of the caffeine-containing compositions.Type: ApplicationFiled: March 10, 2014Publication date: September 11, 2014Inventor: Benjamin M. YU
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Publication number: 20140256752Abstract: The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a coughing condition with such compositions.Type: ApplicationFiled: May 24, 2014Publication date: September 11, 2014Applicant: Biocopea LimitedInventors: John Brew, Robin Mark Bannister
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Publication number: 20140255463Abstract: An energy tablet and method of manufacturing the same that successfully masks the bitter taste of caffeine which has precluded popularity of chewable energy tablets in the past.Type: ApplicationFiled: October 24, 2012Publication date: September 11, 2014Applicant: KICKASS CANDY LLCInventor: Todd Stutzman
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Publication number: 20140249166Abstract: The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor.Type: ApplicationFiled: March 27, 2014Publication date: September 4, 2014Applicant: Kyowa Hakko Kirin Co., Ltd.Inventors: Hiroshi Kase, Akihisa Mori, Yutaka Waki, Yutaka Ohsawa, Akira Karasawa, Yoshihisa Kuwana
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Publication number: 20140242168Abstract: The present invention provides perorally administrable drug release systems and processes for producing perorally administrable systems having a drug-containing core and a sheath which surrounds the core and comprises a swellable shell and an elastic coating which surrounds at least the shell, the sheath having at least one orifice.Type: ApplicationFiled: July 6, 2012Publication date: August 28, 2014Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Christiane Schiller, Knut Seidlitz
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Publication number: 20140235656Abstract: The present invention relates to a stable pharmaceutical composition for sublingual administration comprising a therapeutically effective quantity of an antihistamine agent, in particular Dimenhydnnate and a process for the preparation thereof.Type: ApplicationFiled: October 25, 2011Publication date: August 21, 2014Applicant: EXPERMED S.A.Inventors: Evangelos Karavas, Efthimios Koutris, Vicky Samara, Amalia Diakidou, Aggelos Karatzas
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Publication number: 20140234443Abstract: Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome. Methods of making these compounds are also described in the present invention.Type: ApplicationFiled: March 10, 2014Publication date: August 21, 2014Applicant: Albany Molecular Research, Inc.Inventors: Peter R. GUZZO, David D. MANNING, William EARLEY
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Publication number: 20140221400Abstract: The present invention relates to the use of MPO inhibitors for the treatment of multiple system atrophy. The present invention also relates to the use of MPO inhibitors for the treatment of Huntington's disease. The present invention also relates to the use of MPO inhibitors for neuroprotection.Type: ApplicationFiled: November 8, 2013Publication date: August 7, 2014Applicant: ASTRAZENECA ABInventors: Hakan Eriksson, Werner Poewe
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Patent number: 8796290Abstract: The present invention provides substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity. The present invention also provides processes for preparation of compounds of formula (I).Type: GrantFiled: November 9, 2010Date of Patent: August 5, 2014Assignee: Advinus Therapeutics LimitedInventors: Vidya Ramdas, Summon Koul, Sujay Basu, Yogesh Waman, Yogesh Shejul, Dinesh Barawkar, Venkata Poornapragnacharyulu Palle
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Publication number: 20140212486Abstract: The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), or a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isomer mucate crystal 2, wherein the Isometheptene isomer 2 is stereochemically characterized as (R)-enantiomer, respectively. The Isometheptene (R)-enantiomer activity indicates a selective centrally acting selective ligand for Imidazoline subtype 1 (I1) receptor sites; and more specifically, the disclosure provides an antihypertensive composition for treatment of migraine and other neurovascular or neurogenic pain from abdominal distress. (R)-Isometheptene enantiomer or isomer 2 may be an anti-hypertensive agent with lower side effects than the racemate form. Therefore (R)-Isometheptene is believed to be effective against episodic tension-type headaches (ETTH).Type: ApplicationFiled: January 17, 2014Publication date: July 31, 2014Applicant: TONIX PHARMACEUTICALS INC.Inventors: SETH LEDERMAN, BRUCE DAUGHERTY, LELAND J. GERSHELL, DARRYL RIDEOUT, ANDREW KAWASAKI
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Publication number: 20140206704Abstract: The invention provides starch-based microparticles with high loading capacity for the stabilization and/or controlled release of one or more agents, for example, a pharmaceutical, a taste masking agent, a flavoring agent, or a combination thereof, disposed within the microparticles, and to methods of making and using such microparticles.Type: ApplicationFiled: March 24, 2014Publication date: July 24, 2014Applicant: Paladin Labs Inc.Inventors: Miloud Rahmouni, Mohamed N. Khalid, Vinayak Sant, Abdelaziz Tafer, Damon Smith
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Publication number: 20140200516Abstract: Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, active compound, and optional flavoring agent; formulation II; aqueous polar solvent, active compound, optionally flavoring agent, and propellant; formulation III: non-polar solvent, active compound, and optional flavoring agent; and formulation IV: non-polar solvent, active compound, optional flavoring agent, and propellant.Type: ApplicationFiled: March 18, 2014Publication date: July 17, 2014Applicant: ABBOTT LABORATORIESInventor: Harry A. DUGGER, III
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Publication number: 20140194447Abstract: Compounds and their pharmaceutically acceptable salts for treatment of ?-amyloid diseases, such as observed in Alzheimer's disease and synucleinopathies, such as Parkinson's disease.Type: ApplicationFiled: October 10, 2012Publication date: July 10, 2014Inventors: Luke Esposito, Kelsey Hanson, Marisa C. Yadon, Thomas Lake, Alan D. Snow, Joel Cummings, Anil Kumar
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Publication number: 20140186341Abstract: The present disclosure provides methods for improving drug efficacy in a patient having an obstructed airway in a lung. Such methods modulate nerve activity in the autonomic nervous system of a patient to reduce obstruction of an airway in a lung of the patient prior to administering a drug to the patient. These methods are especially useful in improving efficacies of bronchodilators in treating obstructive lung diseases, such as chronic obstructive pulmonary disease.Type: ApplicationFiled: December 27, 2013Publication date: July 3, 2014Inventor: Martin L. Mayse
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Publication number: 20140179653Abstract: Orally disintegrating film dosage forms for delivering active pharmaceutical agents, methods of formulating the dosage forms to retard absorption through the oral mucosa, and methods of using the dosage forms for the treatment of various medical conditions are provided.Type: ApplicationFiled: October 11, 2013Publication date: June 26, 2014Applicants: APR APPLIED PHARMA RESEARCH SA, LABTEC GESELLSCHAFT FUR TECHNOLOGISCHE FORSCHUNG UND ENTWICKLUNG MBHInventors: Christian Leichs, Armin Breitenbach, Ingo Lehrke, Paolo Galfetti
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Patent number: 8759361Abstract: 2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.Type: GrantFiled: August 22, 2011Date of Patent: June 24, 2014Assignee: Neurogen CorporationInventors: Rajagopal Bakthavatchalam, Scott M. Capitosti, Jianjun Xu, Bertrand L. Chenard, Manuka Ghosh, Charles A. Blum
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Publication number: 20140170226Abstract: Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 nm to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.Type: ApplicationFiled: September 26, 2013Publication date: June 19, 2014Applicant: Dermazone Solutions, Inc.Inventor: Michael W. Fountain
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Publication number: 20140170227Abstract: Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 nm to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.Type: ApplicationFiled: September 26, 2013Publication date: June 19, 2014Applicant: Dermazone Solutions, Inc.Inventor: Michael W. Fountain
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Publication number: 20140161868Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.Type: ApplicationFiled: February 12, 2014Publication date: June 12, 2014Applicant: GENSCO LABORATORIES LLCInventors: Carlos A. Alfaras, Paul M. Zimmerman, Urbano Zamora
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Publication number: 20140142113Abstract: A method of treating inflammatory diseases with Adenosine 2B receptor antagonists in particular with xanthine derived inhibitors. The method involves supplying a therapeutically active amount of the compounds of FIG. 1 and in particular compound 1.Type: ApplicationFiled: November 11, 2013Publication date: May 22, 2014Inventors: Michael W. Burnet, Thomas Stohr, Martin Donsbach
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Publication number: 20140135296Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.Type: ApplicationFiled: May 10, 2012Publication date: May 15, 2014Inventors: Vojo Deretic, Eliseo Castillo, Steven Bradfute, Larry A. Sklar
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Publication number: 20140128415Abstract: A excipient drug composition is disclosed. The excipient drug composition may include a vegetable cellulose or a fruit cellulose, an active ingredient and a genetically modified organism free starch. The vegetable cellulose or fruit cellulose may be derived from wood free vegetable pulp and the fruit cellulose is a wood pulp free cellulose. The genetically modified organism free starch may be selected from the group consisting of a genetically modified organism free rice starch, a genetically modified organism free potato starch or a genetically modified organism free pea starch.Type: ApplicationFiled: January 8, 2014Publication date: May 8, 2014Inventor: Paul Daniel Yered
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Publication number: 20140127150Abstract: An inverse latex including from 20% to 70% by weight and preferably from 25% to 50% by weight of a branched or crosslinked polyelectrolyte, characterized in that the polyelectrolyte is a copolymer of 2-acrylamido-2-methylpropanesulfonic acid partially or totally salified with acrylamide and optionally one or more monomers chosen from monomers containing a partially or totally salified weak acid function and/or from neutral monomers other than acrylamide, the production process including the control of the pH in the initial aqueous phase; Cosmetic, dermopharmaceutical or pharmaceutical composition including the inverse latex directly obtained by the process.Type: ApplicationFiled: January 13, 2014Publication date: May 8, 2014Applicants: Scott Bader Company Limited, Societe D'Exploitation De Produits Pour Les Industries Chimiques SeppicInventors: Olivier BRAUN, Paul MALLO, Audrey BONNARDEL, Francois GUY
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Patent number: 8716301Abstract: A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction.Type: GrantFiled: December 2, 2011Date of Patent: May 6, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Michail V. Sitkovsky, Akio Ohta
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Publication number: 20140121191Abstract: The present invention relates to oral dosage formulations consisting of at least one active ingredient contained in a plurality of hydrophobic carriers dispersed in an aqueous medium comprising a hydrocolloid. The active ingredients include various energy supplements, such as caffeine and vitamins. The formulations may further include emulsifiers, permeation enhancers, and vasodilators. The invention further relates to methods of making the oral dosage formulations.Type: ApplicationFiled: March 25, 2013Publication date: May 1, 2014Inventors: Robert Davidson, Eric Allen, Edward Maliski, Jose Bernado
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Publication number: 20140120160Abstract: A composition including 0.5-40 weight % vegetable extract, 30-90 weight % sugar and 0.5-30 weight % phospholipid for cosmetic, pharmaceutical or dietary uses.Type: ApplicationFiled: December 27, 2013Publication date: May 1, 2014Applicant: LIPOID GmbHInventor: Herbert Rebmann
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Publication number: 20140120042Abstract: Disclosed herein are personal care compositions having at least one oligopeptide self-assembled into nanofibers or macrostructures, wherein the oligopeptide is 2-20 amino acids in length, and wherein the oligopeptide has at least one 0- to 10-amino-acid block of hydrophobic amino acids alternating with at least one 1- to 10-amino-acid block of hydrophilic amino acid residues. The composition may further include a dermatologically acceptable carrier and at least one cosmetic skin care agent.Type: ApplicationFiled: October 29, 2013Publication date: May 1, 2014Applicant: THE PROCTER & GAMBLE COMPANYInventors: Conor David WHITEHOUSE, Ellen Schmidt BAKER, Ioannis Constantine CONSTANTINIDES
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Patent number: 8703189Abstract: The present invention provides a medicinal composition that exhibits excellent storage stability and, even over long-term storage, little change in the release rate of the pharmacologically active substance contained therein. The medicinal composition of the invention prepared by dissolving or dispersing a pharmacologically active substance and a pH-independent water-insoluble polymer in a molten low-melting substance, and which can be prepared by spraying a liquid substance, obtained by dissolving or dispersing the pharmacologically active substance in a molten mixture comprising the low-melting substance and the pH-independent water-insoluble polymer, and then cooling the liquid substance.Type: GrantFiled: May 23, 2002Date of Patent: April 22, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventor: Yuso Tomohira
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Publication number: 20140107048Abstract: Aqueous compositions comprising (a) at least one phenolic compound and (b) at least one hydrotrope in an amount effective to solubilize said at least one phenolic compound in water are provided for cosmetic and other uses.Type: ApplicationFiled: October 12, 2012Publication date: April 17, 2014Applicant: L'Oreal S.A.Inventors: Zhi Pan, Jean-Thierry Simonnet
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Publication number: 20140093490Abstract: The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release.Type: ApplicationFiled: July 23, 2013Publication date: April 3, 2014Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Changjoon Justin LEE, Soo Jin OH, Eun Mi HWANG, Dong Ho WOO
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Patent number: 8685466Abstract: The present document describes methods of use of photo activated compositions for oral disinfection and/or treatments which comprise at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmacologically acceptable carrier.Type: GrantFiled: July 19, 2010Date of Patent: April 1, 2014Assignee: KLOX Technologies Inc.Inventors: Remigio Piergallini, Nikolaos Loupis
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Publication number: 20140086853Abstract: The present invention relates to a personal care composition comprising at least one sucrose fatty acid ester and at least one nonionic surfactant, wherein the composition is substantially free of silicone emulsifiers. The personal care compositions are particularly suitable for conditioning and moisturization applications.Type: ApplicationFiled: September 26, 2012Publication date: March 27, 2014Inventor: Catherine Le Pham
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Publication number: 20140086852Abstract: A personal care composition in the form of an oil-in-water emulsion comprising at least one sucrose fatty acid ester and at least one nonionic surfactant, said composition having a soaping index of less than about 2. The compositions are suitable for conditioning and moisturizing applications, and are optionally substantially free of silicone emulsifiers.Type: ApplicationFiled: September 26, 2012Publication date: March 27, 2014Inventor: Catherine Le Pham
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Publication number: 20140080847Abstract: The invention discloses compositions, including nutritional products and dietary supplements, comprising 1,4-dimethylpentylamine, which is a compound that occurs naturally in the geranium plant. The invention also describes methods comprising the administration of 1,4-dimethylpentylamine to mammals. The methods result in stimulation of the central nervous system, improved mood, increased vigor, increased lipolysis, increased energy expenditure, enhanced exercise performance, and/or decreased appetite. These effects influence energy balance and can promote weight loss, improve body composition, and/or promote fitness and well-being.Type: ApplicationFiled: March 13, 2013Publication date: March 20, 2014Applicant: OEJM Products Holdings, LLCInventor: Jacobo Edward Geissler
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Publication number: 20140073654Abstract: The invention is directed to a method of detecting a biological substance in the nasal secretion and diagnosing a disease following the detection of the biological substance wherein the biological substance is not related to a respiratory disease. The invention also provides treatment of the diseases following the detection of the biological substance and/or diagnosis of the disease. In some embodiments, the diseases are cancer, hepatitis, smell loss, taste loss, diabetes, and leprosy. The invention also provides a kit for diagnosing a disease. The present invention includes methods of analyzing samples from the nose for the detection of biological substances. In particular, nasal secretion or nasal mucus is collected and analyzed for biological substances. The results of this analysis are then suitable for use in diagnosis, prognosis, and determination of suitability of therapeutic interventions.Type: ApplicationFiled: July 1, 2013Publication date: March 13, 2014Inventor: Robert I. Henkin
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Publication number: 20140073632Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of screening for CFTR corrector compounds are also described herein. The methods of screening include contacting a cell that endogenously expresses a CFTR mutation with the compound to be screened and detecting a rescue of halide efflux from the cell.Type: ApplicationFiled: May 17, 2012Publication date: March 13, 2014Applicants: THE UAB RESEARCH FOUNDATION, DISCOVERYBIOMED INC.Inventors: Erik M. Schwiebert, James F. Collawn, Zsuzsa Bebok
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Publication number: 20140073612Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.Type: ApplicationFiled: September 11, 2012Publication date: March 13, 2014Inventors: Carlos A. Alfaras, Paul M. Zimmerman, Urbano Zamora
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Publication number: 20140073655Abstract: The present invention refers to an active moiety of Paullinia cupana with enhanced activity against fatigue. Particularly related to cancers, and its manufacturing process, pharmaceutical compositions and drugs containing the same. Another object of the present invention is a method for treating fatigue, particularly related to cancers.Type: ApplicationFiled: March 30, 2012Publication date: March 13, 2014Inventors: Luiz Francisco Pianowski, JoaƵ Batista Calixto, Auro Del Giglio
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Patent number: 8663684Abstract: The present invention concerns a process for producing a granulate based on lactose and cellulose (derivative), a granulate obtainable by the process and its use as a tabletting excipient.Type: GrantFiled: September 21, 2009Date of Patent: March 4, 2014Assignee: Molkerei Meggle Wasserburg GmbH & Co. KGInventors: Eugen Schwarz, Gernot Warnke, Vera Fichtner
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Publication number: 20140056922Abstract: A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction.Type: ApplicationFiled: October 30, 2013Publication date: February 27, 2014Applicant: The United States of America,as represented by the Secretary, Department of Health and Human ServiceInventors: Michail V. Sitkovsky, Akio Ohta
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Patent number: 8658219Abstract: There is provided a skin rejuvenation composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.Type: GrantFiled: November 6, 2009Date of Patent: February 25, 2014Assignee: KLOX Technologies Inc.Inventors: Remigio Piergallini, Nikolaos Loupis, Francesco Bellini
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Publication number: 20140051693Abstract: Cerebral palsy impaired speech in children and adolescents are effectively treated by administration of a psychostimulant. Low doses of the psychostimulant significantly increases the percentage of correctly pronounced intelligible syllables or words and the ability to more intelligibly communicate. The improvement in speech persists after cessation of or prior to continued psychostimulant treatment.Type: ApplicationFiled: October 22, 2013Publication date: February 20, 2014Inventors: Bruce Roseman, Gilla Kaplan
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Publication number: 20140045824Abstract: The present invention relates to a method for producing a complex crystal composed of two or more different compounds, comprising crystallizing the two or more different compounds under a condition at which menthol is heat melted, and a method for screening a complex crystal. In accordance with the method for producing a complex crystal of the present invention, a complex crystal capable of being used as a drug material can be produced rapidly, simply and efficiently. In addition, in accordance with the method for screening a complex crystal of the present invention, a stable complex crystal can be searched, which is industrially useful.Type: ApplicationFiled: April 20, 2012Publication date: February 13, 2014Inventors: Akinori Goto, Mamoru Fukuda
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Patent number: 8637086Abstract: There is provided a skin rejuvenation composition which comprises at least one oxidant, at least one photoactivator capable of activating the oxidant, and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin, in association with a pharmaceutically acceptable carrier.Type: GrantFiled: February 19, 2013Date of Patent: January 28, 2014Assignee: KLOX Technologies Inc.Inventors: Remigio Piergallini, Nikolaos Loupis, Francesco Bellini
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Patent number: 8632822Abstract: There is provided wound healing composition which comprises at least one oxidant, at least one photoactivator capable of actuating the oxidant and at least one healing factor chosen from hyaluronic acid, glucosamine and allantoin in association with a pharmaceutically acceptable carrier. In addition, a method of topically treating wounds using at least one oxidant and at least one photoactivator capable of activating the oxidant followed by illumination of said photosensitizer is disclosed.Type: GrantFiled: November 6, 2009Date of Patent: January 21, 2014Assignee: KLOX Technologies Inc.Inventors: Remigio Piergallini, Nikolaos Loupis, Francesco Bellini
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Patent number: 8618118Abstract: A medication formulation and method of use for treating migraine having a combination of active ingredients including: nicotine, phenylalanine, tyrosine, and caffeine in an aqueous solution.Type: GrantFiled: January 26, 2012Date of Patent: December 31, 2013Inventor: Joseph Robert Knight
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Publication number: 20130323296Abstract: The present disclosure relates to a carrier for oromucosal, especially sublingual administration of physiologically active substances, especially of medicinal drugs, which consists of at least one elastic layer (1) of polymer nanofibres workable according to the shape of the selected wall of mouth cavity to which it should be applied and in this elastic layer (1) of polymer nanofibres a drug and/or other physiologically active substance are deposited in a releasable manner.Type: ApplicationFiled: December 12, 2011Publication date: December 5, 2013Inventors: Denisa Stranska, Adela Klabanova, Pavel Dolezal, Petr Vrbata, Pavel Berka, Marie Musilova
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Publication number: 20130324503Abstract: The present invention relates to methods of treatment for Parkinson Disease (PD) in a person by identifying gene variants which may indicate a more favorable response to specific medicaments, thereby allowing for personalized or individualized treatment. The present invention relates to a method of screening for a genetic predisposition to PD in a person. The present invention is also directed to a method of testing a person for the presence of particular gene variants, wherein the presence of a gene variant indicates a higher predisposition to PD, and the absence of a gene variant indicates a lower predisposition to PD, compared to a control sample. The present invention further relates to methods and kits for treating, or inhibiting the development of, PD in a person. The present invention is also directed to a method of identifying the heritage of an individual based on the genetic profile of the individual.Type: ApplicationFiled: October 19, 2012Publication date: December 5, 2013Applicants: Health Research Inc., Emory University School of Medicine, National Institute of Environmental Health Sciences, Veterans Affairs Puget Sound Health Care System, Oregon Health & Science UniversityInventors: Haydeh Payami, Taye H. Hamza, Stewart A. Factor, John Nutt, Cyrus Zabetian, Honglei Chen, Erin Hill Burns
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Publication number: 20130316024Abstract: A cosmetic kit and the use thereof for improving the appearance of the skin is described. Further described, is the prevention and/or controlling of cellulite or the orange peel syndrome and/or for slimming down the figure, through the increase of the elasticity and firmness of the skin by stepping up collagen synthesis, for increasing blood microcirculation and for improving thermoregulation of the skin.Type: ApplicationFiled: November 18, 2011Publication date: November 28, 2013Applicant: RHODIA POLIAMIDA E ESPECIALIDADES LTDAInventors: Gabriel Gorescu, Thomas Canova, Tarcis Cordeiro Bastos, Karla Laguens