Abstract: This invention is directed to the use of spinosyn or a physiologically acceptable derivative or salt thereof for improved production of fish; controlling ectoparasite infestations in aquaculture raised fish; and fish feed formulations.
Type:
Grant
Filed:
May 15, 2006
Date of Patent:
February 1, 2011
Assignee:
Eli Lilly and Company
Inventors:
Clayton Paul Dick, Daniel Earl Snyder, Joseph Raymond Winkle
Abstract: The invention relates to novel fungicidally active compound combinations of 2?-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and active compounds listed in the disclosure.
Abstract: The invention relates to a pesticidal composition comprising as active ingredient a mixture consisting of one compound (A) as defined in the patent claims and at least one compound (B) as defined in the patent claims, to a process for the preparation of and to the use of such a composition, to a method of controlling pests using such a composition and to plant propagation material treated with such a composition.
Abstract: The present invention relates to targets of loss of imprinting (LOI) affected IGF2 gene products in pre-malignant tissues, where methods of inhibiting those targets, including IGFR1, are disclosed to prevent tumor development in subjects at risk for developing colorectal cancer (CRC). The present invention also relates to methods of identifying increased risk in developing CRC in a subject, including methods of assessing the efficacy of a chemotherapeutic regimen. Further, the present invention relates to methods for identifying anti-neoplastic agents.
Type:
Application
Filed:
December 7, 2007
Publication date:
January 20, 2011
Inventors:
Andrew P. Feinberg, Andre Levchenko, Dan L. Longo, Minoru S.H. Ko
Abstract: A process for the production of insecticide-modified bead material composed of expandable polystyrene (EPS) by extrusion, encompassing the steps of a) mixing, in a mixer, to incorporate a blowing agent and at least one insecticide from the group of the phenylpyrazoles, chlorfenapyr and hydramethylnon into a polymer melt which comprises at least one polystyrene, based on a vinylaromatic monomer, b) discharging the polymer melt comprising blowing agent, and c) pelletizing the polymer melt comprising blowing agent.
Type:
Application
Filed:
December 5, 2008
Publication date:
January 6, 2011
Applicant:
BASF SE
Inventors:
Michael Ishaque, Olaf Kriha, Carsten Schips, Norbert Güntherberg, Daniela Longo, Klaus Hahn, Bernhard Schmied, Clark D. Klein, Keith A. Holmes
Abstract: The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to Clostridium difficile (“C. difficile”), Clostridium perfringens (“C. perfringens”), Staphylococcus species, for example, methicillin-resistant Staphylococcus, or Enterococcus including Vancomycin-resistant enterococci.
Type:
Grant
Filed:
April 11, 2008
Date of Patent:
January 4, 2011
Assignee:
Optimer Pharmaceuticals, Inc.
Inventors:
Yu-Hung Chiu, Tessie Mary Che, Alex Romero, Yoshi Ichikawa, Youe-Kong Shue
Abstract: Disclosed are compounds of Formula 1, wherein X is O or S; Y is O or S; and R1, R2, R3 and R4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.
Type:
Application
Filed:
January 30, 2009
Publication date:
December 23, 2010
Applicant:
E.I. DU Pont De Nemours and Company
Inventors:
Caleb William Holyoke, JR., My-Hanh Thi Tong, Reed Aaron Coats, Wenming Zhang, Stephen Frederick McCann, Dominic Ming-Tak Chan
Abstract: The novel active compound combinations comprising compounds of the formulae (I) and (II) have very good insecticidal and acaricidal properties.
Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one proteinaceous material and at least one polymeric material. In this embodiment, the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least one polymeric material. Still, alternative embodiment pesticide compositions exhibiting enhanced activity levels are disclosed.
Type:
Application
Filed:
April 27, 2010
Publication date:
November 25, 2010
Inventors:
Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, JR., James E. Dripps, Margaret S. Kempe
Abstract: The present invention relates to novel active compound combinations comprising at least one known compound of the formula (I) in which R is as defined in the description, and at least one further known active compound from the classes of the benzenedicarboxamides, the macrolides, the diacylhydrazines, the carboxylates or another class. Combinations of the present invention are highly suitable for controlling animal pests such as insects and unwanted acarids.
Type:
Application
Filed:
March 19, 2007
Publication date:
November 25, 2010
Applicant:
BAYER CROPSCIENCE AG
Inventors:
Heike Hungenberg, Peter Jeschke, Rüdiger Fischer, Robert Velten, Thomas Schenke, Wolfram Andersch, Wolfgang Thielert
Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient. The at least one co-ingredient may include at least one metal oxide, a combination of at least one transition metal salt and at least one proteinaceous material or a combination of at least one proteinaceous material and at least one polymeric material. The method further includes spray drying the liquid composition to provide a solid composition. In one aspect of this embodiment, the solid composition provided by the spray drying exhibits enhanced pesticidal activity compared to the liquid composition.
Type:
Application
Filed:
April 27, 2010
Publication date:
November 25, 2010
Inventors:
Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, JR., James E. Dripps, Margaret s. Kempe, Martin C. Logan, Douglas J. Linscott, John M. Atkinson
Abstract: We describe the functional cloning and the use of a non-fungal inositol phosphoryceraminde synthase (IPC synthase) in a screening assay for the identification of agents that target and antagonize the activity of IPC synthase.
Type:
Application
Filed:
January 19, 2007
Publication date:
November 18, 2010
Applicant:
The University of Durham
Inventors:
Paul William Denny, Ralph Thomas Schwarz, Hosam Shams-Eldin
Abstract: Provided are novel methods and formulations for systemically controlling ectoparasite infestations in animals using spinetoram or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
May 4, 2010
Publication date:
November 11, 2010
Inventors:
Daniel Earl Snyder, William Hunter White
Abstract: Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
Type:
Grant
Filed:
October 1, 2009
Date of Patent:
October 12, 2010
Assignees:
University of Kansas, The United States of America as represented by the Department of Health and Human Services
Inventors:
Brian S. Blagg, Len Neckers, Xiao Ming Yu
Abstract: The invention relates to the novel use of known active substance combinations which consist firstly of 3,4-dichloro-2?-cyano-1,2-thiazole-5-carboxanilide, of the formula which is known, and secondly further known insecticidal active substances, for controlling animal pests, especially arthropods, in particular insects.
Type:
Application
Filed:
November 27, 2008
Publication date:
September 30, 2010
Applicant:
Bayer CropScience AG
Inventors:
Lutz Assmann, Ulrike Wachendorff-Neumann, Heike Hungenberg, Wolfgang Thielert
Abstract: The present invention relates to formulations of concentrated azalide antibiotics and methods for making and using them. Specifically, the invention relates to a method of treating an infection comprising administering to a patient in need thereof, an effective amount of a concentrated aqueous azalide antibiotic formulation made according to the method comprising dissolving an azalide antibiotic in an aqueous solution comprising a strong acid. The invention also relates to methods for making concentrated aqueous azalide antibiotic formulations for use in pulmonary infection, a nasopharyngeal infection, an otic infection, an ocular infection, a dermal or a vaginal infection. The invention also relates to concentrated aqueous azalide antibiotic formulations made by dissolving an azalide antibiotic in an aqueous solution comprising a strong acid.
Type:
Grant
Filed:
October 4, 2007
Date of Patent:
September 14, 2010
Assignee:
Insite Vision Incorporated
Inventors:
Lyle Bowman, S. Kumar Chandrasekaran, Roy Duane Archibald, Stephen Pham, David Mufson
Abstract: The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is used in the treatment or prophylaxis of parasites in mammals, in particular swine and horses. The invention further relates to a method to extend the shelf life of a stable premix feed or feed-like formulation for the treatment or prophylaxis of parasite infestation in swine and horses comprising controlling the amount of an already existing antioxidant or stabilizer in the formulation to decrease or to prevent the formation of acid/base catalyzed decomposition of the active ingredient.
Abstract: A male annihilation insecticide formulation, having a viscosity appropriate for use in aerial or backpack spray applications and suitable for on-crop or off-crop uses, comprises an insect toxicant and a male-specific attractant, such as a parapheromone, for a target insect species, such as fruit fly, dispersed and entrapped in an emulsion comprising a biodegradable wax, an emulsifiers, and water.
Type:
Application
Filed:
May 7, 2010
Publication date:
August 26, 2010
Applicants:
Dow AgroSciences LLC, ISCA Technologies Inc.
Inventors:
Raymond E. Boucher, JR., Reginald Coler, Mark Hertlein, Steve Tuttle, Agenor Mafra-Neto
Abstract: The novel active compound combinations comprising a compound of the formula (I-1) or (I-2) and the active compounds (1) to (26) listed in the description have very good insecticidal and acaricidal properties.
Type:
Application
Filed:
July 6, 2007
Publication date:
August 12, 2010
Inventors:
Reiner Fischer, Wolfram Andersch, Thomas König, Anton Kraus, Emmanuel Salmon, Heike Hungenberg
Abstract: The present invention relates to an active composition for controlling or eradicating Phthiraptera, Siphonaptera and Acarina Pests, typically in domestic animals, comprising a synergistic combination of at least one A83543 compound and at least one macrocyclic lactone. The invention also relates to the use of the active composition in pesticidal formulations, the formulations themselves and to the various applications of those formulations as pesticides, specifically in controlling all species of Phthiraptera, Siphonaptera and Acarina pests, typically in domestic animals. Such applications include the control of such external Phthiraptera, Siphonaptera and Acarina pests in domestic animals including but not limited to sheep, cattle, poultry, pigs, goats, camelids, horses, dogs and cats.
Type:
Application
Filed:
April 9, 2010
Publication date:
August 5, 2010
Applicant:
ELI LILLY AND COMPANY
Inventors:
Lionel Barry LOWE, James Terence ROTHWELL
Abstract: The present invention provides a pesticidal composition comprising a compound represented by the formula (I): wherein A, B, R, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description, and 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether as active ingredients, and also provides a pest control method which comprises the step of applying an effective amount of the compound represented by the above formula (I) and an effective amount of 2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether to pests or a place where pests inhabit.
Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, cyclic ketoenols or other acaricidally active compounds and, secondly, further insecticidally active compounds from the group of the anthranilamides, which combinations are highly suitable for controlling animal pests, such as insects and unwanted acarids.
Type:
Application
Filed:
March 9, 2010
Publication date:
July 1, 2010
Applicant:
BAYER CROPSCIENCE AG
Inventors:
Christian Funke, Thomas Bretscheneider, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Ánton Kraus
Abstract: The novel active compound combinations comprising compounds of the formula (I) and spinetoram have very good insecticidal and/or acaricidal properties.
Abstract: Compounds able to affect production and/or activity of a redox active compound, which include candidate therapeutic compounds and candidate compounds for enhancing power output of a microbial fuel cell, and related compositions, methods and systems.
Type:
Application
Filed:
August 26, 2009
Publication date:
May 20, 2010
Inventors:
Dianne K. Newman, Lars E.P. Dietrich, Yun Wang
Abstract: An isoflavone composition which contains an ?-glucosyl isoflavone and isoflavone and optionally an isoflavone aglycone, wherein the ratio of the amount of aglycone in the isoflavone and the isoflavone aglycone in total to the amount of aglycone in the ?-glucosyl isoflavone [(the amount of aglycone in ?-glucosyl isoflavone)/(the amount of aglycone in isoflavone plus the amount of isoflavone aglycone)] is at least 2.5/1; a water-soluble isoflavone composition which contains an ?-glucosyl isoflavone, isoflavone and isoflavone aglycone, wherein the ratio of the amount of isoflavone aglycone in the composition is 0.01 to 20% to the total amount of aglycone in the composition; and beverages, cosmetics, pharmaceuticals, or feeds, which contain any one of the above compositions.
Abstract: Mixtures containing gamma-cyhalothrin [(S)-?-cyano-3-phenoxybenzyl (Z)-(1R,3R)-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate] and another compound having insecticidal, nematicidal, acaricidal, molluscicidal, fungicidal, plant growth regulating or herbicidal activity are provided. Compositions containing the mixture and insecticidal methods using such mixtures or compositions are also provided.
Abstract: What is described are a compound of the formula (I) Wherein U is —N(R2)OR3 or —N+(O?)?C(RE)RZ); n is 0 or 1; X—Y is —CH?CH— or —CH2—CH2—; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and R3 are, for example; independently from each other, —Q, —C(?O)—Z—Q or —CN; RZ and RE are, independently from each other, —Q, —C(?O)—Z—Q or —CN; or RZ and RE together are a three- to seven membered alkylene or alkenylene bridge, which is unsubstituted or mono- to tri-substituted; Z is a bond, O or —NR4—; Q is H, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, C3-C12-Cycloalkyl, C5-C12-cycloalkenyl, aryl, or heterocyclyl, which are unsubstituted or mono- to pentasubstituted; R4 is for example H, C1-C8alkyl, hydroxy-C1-C8alkyl, C3-C8cycloalkyl or C2-C8alkenyl; or, if appropriate, an E/Z isomer, E/Z isomer mixture and/or tautomer thereof; a process for preparing these compounds, their isomers and tautomers and the use of these compounds, their isomers and tautomers; pesticidal compositions whose active compound is selected
Type:
Grant
Filed:
January 30, 2004
Date of Patent:
March 16, 2010
Assignee:
Merial Limited
Inventors:
Thomas Pitterna, Fiona Murphy Kessabi, Peter Maienfisch, Jerome Cassayre, Laura Quaranta, Pierre Jung
Abstract: The present invention relates to novel active compound combinations consisting, firstly, of formononetin and, secondly, of known insecticidally active compounds, which active compound combinations are highly suitable for controlling unwanted animal pests, such as insects or acarids, or nematodes.
Type:
Application
Filed:
November 16, 2007
Publication date:
February 25, 2010
Applicant:
BAYER CROPSCIENCE AG
Inventors:
Wolfram Andersch, Heike Hungenberg, Darren Mansfield
Abstract: In one aspect of the application, a termite bait, monitoring device or other termite control device includes a plurality of cellulosic food material pieces palatable to termites embedded within a water resistant polyurethane foam matrix. In another aspect, a termite bait, monitoring device or other termite control device includes a plurality of cellulosic food material pieces palatable to termites embedded within a water-absorbent polyurethane foam matrix. In another aspect a termite bait, monitoring device or other termite control device includes at least one cellulosic food material piece encapsulated within a water resistant polyurethane foam coating. In another aspect of the application, a termite control device includes a container, a cellulosic food material within the container and a water resistant polyurethane foam positioned to separate the food material from its environment.
Type:
Application
Filed:
August 18, 2009
Publication date:
February 25, 2010
Inventors:
Joseph Edward Eger, JR., Donald E. Williams, III, Sol M. Mirasol, Mike P. Tolley, Joseph J. DeMark, Matthew T. Messenger, Phillip J. Howard
Abstract: This invention relates to a novel class of antibiotic agents, more specifically to macrolides comprising an oxazolidinone structure, their preparation, pharmaceutical compositions containing them, their use and methods of treatment using them.
Abstract: The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).
Type:
Application
Filed:
November 28, 2008
Publication date:
February 11, 2010
Applicant:
OPTIMER PHARMACEUTICALS, INC.
Inventors:
Yoshi Ichikawa, Yu-Hung Chiu, Youe-Kong Shue, Farah Kondori Babakhani
Abstract: An improved pesticide delivery system is disclosed. The system is based on a microblend comprising (a) an amphophilic compound containing at least one hydrophilic group and at least one hydrophobic group and (b) a second compound. Compositions based on the microblend and methods of using the compositions to control pests are also disclosed.
Type:
Application
Filed:
January 10, 2007
Publication date:
December 10, 2009
Applicant:
Innovation Technologies, LLC
Inventors:
Alexander V. Kabanov, Tatiana K. Bronitch, Michael Karas, Bruce L. Frank
Abstract: Novobiocin analogues and pharmaceutical composition containing such compounds useful for the treatment and/or prevention of neurodegenerative disorders and autoimmune disorders.
Type:
Grant
Filed:
May 10, 2007
Date of Patent:
November 24, 2009
Assignee:
University of Kansas
Inventors:
Brian Blagg, Mary Lou Michaelis, Michelle McIntosh
Abstract: Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
Type:
Grant
Filed:
November 3, 2005
Date of Patent:
October 27, 2009
Assignee:
University of Kansas
Inventors:
Brian S. Blagg, Len Neckers, Xiao Ming Yu
Abstract: A compound of formula (I); that has the S-configuration at the 4?-position and wherein the bond between carbon atoms 22 and 23 is a single or a double bond; R1 is C1-C12alkyl, C3-C8cycloalkyl; or C2-C12alkenyl; R2 is H, or, for example, unsubstituted or mono- to penta-substituted C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl or C1-C6alkoxy-C1-C6alkyl; R3 is H or, for example, C1-C12alkyl; X is a bond, O, NR4 or S; and Z is C?O, C?S or S02; and, where applicable, E/Z isomers, mixtures of E/Z isomers and/or tautomers, in each case in free form or in salt form; a process for the preparation of and the use of those compounds and their isomers and tautomers; starting materials for the preparation of the compounds of formula (I); pesticidal compositions in which the active ingredient has been selected from those compounds and their tautomers; and a method of controlling pests using those compositions are described.
Abstract: Compounds of the avermectin family or derivatives thereof, notably emamectins are formulated into pharmaceutical compositions useful for the treatment of dermatological conditions in humans, in particular rosacea.
Abstract: The invention provides an aqueous composition comprising a dissolved polyene fungicide and a solubilizer, wherein at least 100 ppm of polyene fungicide is present as dissolved polyene fungicide. The aqueous compositions of the invention may further comprise a chelating and/or antioxidation agent. The compositions of the invention provide dissolved polyene fungicides in a more stable form. The present invention further provides uses of the compositions of the inventions and methods of making such compositions.
Type:
Application
Filed:
May 18, 2009
Publication date:
October 22, 2009
Applicant:
DSM IP ASSETS B.V.
Inventors:
Ben Rudolf de Haan, Jacobus Stark, Hong Sheng Tan
Abstract: The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contact mucus in an amount, at a frequency, and for a duration effective to prevent, reduce, or eliminate non-invasive fungus-induced rhinosinusitis. This invention also provides methods and materials for diagnosing non-invasive fungus-induced rhinosinusitis and culturing non-invasive fungus from a mammalian mucus sample as well as specific antifungal formulations and medical devices for treating and preventing non-invasive fungus-induced rhinosinusitis. In addition, the invention provides methods and materials for treating and preventing other non-invasive fungus-induced mucositis conditions such as chronic otitis media, chronic colitis, and Crohn's disease. Further, the invention involves methods and materials for treating and preventing chronic asthma symptoms.
Abstract: The present invention relates to dermal vaccine formulations, designed for targeted delivery of an immunogenic composition to a dermal compartment of skin including the intradermal and epidermal compartments. The dermal vaccine formulations of the invention comprise an antigenic or immunogenic agent, and at least one molecule, e.g., a chemical agent, which enhances the presentation and/or availability of the antigenic or immunogenic agent to the immune cells of the intradermal compartment or epidermal compartment resulting in an enhanced immune response. The dermal vaccine formulations of the invention have enhanced efficacy as the antigenic or immunogenic agent is delivered to the intradermal compartment or epidermal compartment with enhanced presentation and/or availability to the immune cells that reside therein.
Type:
Grant
Filed:
December 6, 2004
Date of Patent:
September 15, 2009
Assignee:
Becton, Dickinson and Company
Inventors:
Robert L. Campbell, Kevin G. Dolan, Wendy D. Woodley
Abstract: The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R1 and R5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R2, R3, and R4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R5 may be bound on meta-position against heptylene group of another aryl group to form a ring.
Abstract: Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol and a polycarboxylic acid.
Abstract: The present invention provides compositions and methods for treating otic disorders. More specifically, the present invention describes the use of agents that down-regulate expression of Tanis and/or p21Waf1/Cip1/Sd1 genes to treat such disorders of the ear.