N-c(=x)x Containing (x Is Chalcogen) Doai Patents (Class 514/476)
- With an additional active ingredient (Class 514/479)
- Polycyclo ring system attached by nonionic bonding (Class 514/480)
- N-C(=X)-N, N-C(=N)N, N-N, nitrogen directly bonded to oxygen by nonionic bonding or cyano containing (Class 514/482)
- Plural N-C(=X)-X groups (Class 514/483)
- Ring in acid moiety (Class 514/484)
- Ring in alcohol moiety (Class 514/489)
-
Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
-
Patent number: 6075023Abstract: Fish mycoses and single-cell ectoparasites on fish are controlled using an active compound suitable for inhibiting the mitochondrial respiratory chain at the stage of the b/c.sub.1 complex.Type: GrantFiled: February 17, 1998Date of Patent: June 13, 2000Assignee: BASF AktiengesellschaftInventors: Gerhard Peter Dohmen, Christoph Kunast, Reinhart Munk, Gerhard Rothhaas
-
Patent number: 6057363Abstract: New active compound combinations of valinamide derivatives of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 has the meaning given in the description,with known fungicidal active substances, and their use for combating phytopathogenic fungi are described.Type: GrantFiled: July 6, 1998Date of Patent: May 2, 2000Assignee: Bayer AktiengesellschaftInventors: Heinz-Wilhelm Dehne, Wilhelm Brandes, Karl-Heinz Kuck, Thomas Seitz
-
Patent number: 6030924Abstract: The novel solid formulations obtained by low pressure extrusion of a mixture comprisingat least one active ingredient; andat least one defoaming agent and/or foam breaking agent from thegroup consisting of perfluoroalkylphosphinic acids and/orperfluoroalkylphosphonic acids and/or their salts,show foam breaking activities even after extrusion, drying and storage at elevated temperatures and are thus very suitable for preparing tank mixtures for use in crop protection.Type: GrantFiled: May 1, 1998Date of Patent: February 29, 2000Assignee: American Cyanamid CompanyInventors: Winfried Mayer, Christian Wassmer, Sandra Doerr
-
Patent number: 6020317Abstract: The object of the invention is to provide a lipid device functionally equivalent to the so-called cationic liposome and of lesser toxicity and a lipid or the like as a component of the device.The compound of the invention includes but is not limited to 3-O-(4-dimethylaminobutanoyl)-1,2-O-dioleylglycerol, 3-O-(2-dimethylaminoethyl)carbamoyl-1,2-O-dioleylglycerol, 3-O-(2-diethylaminoethyl) carbamoyl-1,2-O-dioleylglycerol and 2-O-(2-diethylaminoethyl) carbamoyl-1,3-O-dioleoylglycerol. The device of the invention comprises such a lipid and a phospholipid.By administering a double-stranded RNA, for instance, together with the device of the invention, the double-stranded RNA can be safely delivered to the site of action.Type: GrantFiled: October 23, 1995Date of Patent: February 1, 2000Assignee: Nippon Shinyaku Co. Ltd.Inventors: Yano Junichi, Tadaaki Ohgi
-
Patent number: 5989597Abstract: A process for continuously and instantaneously sterilizing soil comprising the steps of applying a water-activated chemical fumigant below the surface of the soil which simultaneously applying water to the soil below the surface. The soil, chemical fumigant and water are throughly mixed to cause instantaneous reaction of 100% of the chemical fumigant to produce a fumigant gas. Immediately covering the treated soil with a gas impervious material to retain the gas within the soil and kill the pathogens contained therein. Thereafter innoculating the soil with antgonistic organisms for preventing recontamination of the soil.Type: GrantFiled: December 26, 1995Date of Patent: November 23, 1999Inventor: Ambrose H. J. Rajamannan
-
Patent number: 5977147Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.Type: GrantFiled: April 24, 1996Date of Patent: November 2, 1999Assignee: Hoechst Marion RousselInventors: John Joseph Tegeler, Barbara Seavey Rauckman, Russell Richard Lee Hamer, Brian Scott Freed, Gregory Harold Merriman
-
Patent number: 5973000Abstract: The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, and a and b are 0 or 1, as well as its use. Thus, there is provided a hair revitalizing tonic composition having an excellent hair loss prevention and hair revitalizing effect and, moreover, an excellent dandruff and itchy scalp prevention effect.Type: GrantFiled: June 3, 1997Date of Patent: October 26, 1999Assignees: Shiseido Company, Ltd., Takeda Chemical Industries, Ltd.Inventors: Tsunao Magara, Yoshiharu Tsuji, Chika Hamada, Yosuke Nakazawa, Eriko Takeoka, Masahiro Tajima, Masazumi Watanabe
-
Patent number: 5962518Abstract: There are described new active compound combinations of a compound of the formula (I) ##STR1## with known fungicidal active compounds, and their use for combating phytopathogenic fungi.Type: GrantFiled: October 1, 1997Date of Patent: October 5, 1999Assignee: Bayer AktiengesellschaftInventors: Klaus Stenzel, Wilhelm Brandes, Stefan Dutzmann, Bernd-Wieland Kruger, Karl-Heinz Kuck, Rolf Pontzen, Thomas Seitz, Atsumi Kamochi, Ikuya Saitoh
-
Patent number: 5958971Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.Type: GrantFiled: October 22, 1997Date of Patent: September 28, 1999Assignees: Zeneca Limited, Cancer Research Campaign Technology LimitedInventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger, Caroline Joy Springer
-
Patent number: 5952386Abstract: The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.10 alkyl or the like; L is C(.dbd.O)NH or the like; R.sub.2, R.sub.3 and R.sub.4 are independently halogen or the like; R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen or the like; m is an integer of 0 to 4; n is an integer of 0 to 2; X is chlorine or the like; Y is oxygen or the like; and Z is oxygen or the like, which have excellent insecticidal activity so that they are satisfactorily effective for the control of noxious insects.Type: GrantFiled: September 24, 1997Date of Patent: September 14, 1999Assignee: Sumitomo Chemical Company, LimitedInventors: Sanshiro Matsuo, Taro Hirose, Keiichi Izumi, Masaya Suzuki, Noriyasu Sakamoto, Kazunori Tsushima, Shigeru Saito, Hirotaka Takano
-
Patent number: 5939454Abstract: A fungicidal mixture comprisesa) an oxime ether carboxamide of the formula I ##STR1## where R is hydrogen or halogen andb) a dithiocarbamate (II) selected from the group consisting ofmanganese ethylenebis(dithiocarbamate) (zinc complex) (IIa),manganese ethylenebis(dithiocarbamate) (IIb),zinc ammoniate ethylenebis(dithiocarbamate) (IIc) andzinc ethylenebis(dithiocarbamate) (IId)in a synergistically active amount.Type: GrantFiled: January 20, 1998Date of Patent: August 17, 1999Assignee: BASF AkdtiengesellschaftInventors: Barbara Schwalge, Ruth Muller, Herbert Bayer, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann
-
Patent number: 5922761Abstract: In accordance with the present invention, there are provided methods for the in vivo reduction of free iron ion levels in a mammalian subject. The present invention employs a scavenging approach whereby free iron ions are bound in vivo to a suitable physiologically compatible scavenger. The resulting complex renders the free iron ions harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods. An exemplary scavenger contemplated for use in the practice of the present invention is a dithiocarbamate-containing composition. This material binds to free iron ions, forming a stable, water-soluble dithiocarbamate-iron complex.Type: GrantFiled: September 6, 1996Date of Patent: July 13, 1999Assignee: Medinox, Inc.Inventor: Ching-San Lai
-
Patent number: 5902828Abstract: A fungicidal mixture comprisinga) the oxime ether carboxylic ester of the formula I ##STR1## and b) a dithiocarbamate (II) selected from the group consisting ofmanganese ethylenebis(dithiocarbamate) (zinc complex) (IIa),manganese ethylenebis(dithiocarbamate) (IIb),zinc ammoniate ethylenebis(dithiocarbamate) (IIc) andzinc ethylenebis(dithiocarbamate) (IId)in a synergistically effective amount.Type: GrantFiled: December 4, 1996Date of Patent: May 11, 1999Inventor: Eberhard Ammermann
-
Patent number: 5891908Abstract: Fungicidal mixtures comprisinga) the oxime ether carboxylic ester of the formula I ##STR1## and b) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (II)H.sub.3 CCH.sub.2 --NHCONH--C (CN).dbd.NOCH.sub.3 IIin a synergistically effective amount.Type: GrantFiled: December 10, 1996Date of Patent: April 6, 1999Assignee: BASF AktiengesellschaftInventors: Eberhard Ammermann, Gisela Lorenz, Dietrich Mappes, Klaus Schelberger, Manfred Hampel
-
Patent number: 5858402Abstract: In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in vivo to a suitable scavenger. The resulting complex renders the cyanide harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods.Type: GrantFiled: February 11, 1997Date of Patent: January 12, 1999Assignee: Medinox, Inc.Inventor: Ching-San Lai
-
Patent number: 5856354Abstract: The invention concerns tachykinin antagonists. The compounds are neopeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included. The compounds are expected to be especially useful in asthma and rheumatoid arthritis.Type: GrantFiled: October 17, 1997Date of Patent: January 5, 1999Assignee: Warner-Lambert CompanyInventors: David Christopher Horwell, William Howson, Martyn Clive Pritchard, Edward Roberts, David Charles Rees
-
Patent number: 5846997Abstract: The present invention relates to water-emulsifiable liquid formulations of insecticidal active compounds, characterized in that they containa) 2.5 to 30% of active compound,b) 5 to 77.5% of a mixture of benzyl acetate and an alcohol in the ratio 25-95% to 5-75%,c) 2.5 to 20% of formulation auxiliary.Type: GrantFiled: April 29, 1996Date of Patent: December 8, 1998Assignee: Bayer AktiengesellschaftInventors: Kirkor Sirinyan, Rainer Sonneck, Klaus Mrusek
-
Patent number: 5814667Abstract: The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.Type: GrantFiled: March 11, 1997Date of Patent: September 29, 1998Assignee: United States of America as represented by the Department of Health and Human ServicesInventors: James B. Mitchell, Angelo Russo, Murali C. Krishna, David A. Wink, Jr., James E. Liebmann
-
Patent number: 5811456Abstract: Novel monoamine oxidase B inhibitors of formula (I), wherein R.sub.1 .dbd.H, an optionally substituted benzyloxy or phenylethoxy group; p=0-3; R.sub.3 .dbd.H, a CN, OH, CCH group, a C.sub.1 -C.sub.3 alkoxy-carbonyl group, or a C.sub.1 -C.sub.3 alkylated cyanomethyl group; R.sub.2 .dbd.H or a C.sub.1 -C.sub.3 alkyl group; n=0 or 1; if n=0, R.sub.4 is a C.sub.1 -C.sub.3 alkyl group or a C.sub.1 -C.sub.3 alkoxy group, while if n=1, y=1 and R.sub.4 is a C.sub.1 -C.sub.3 alkyl group, a C.sub.1 -C.sub.3 alkoxy group or a phenyl group. The invention also concerns processes for the preparation of said novel inhibitors and the therapeutic use thereof.Type: GrantFiled: August 6, 1996Date of Patent: September 22, 1998Assignees: Laboratoires Mayoly Spindler, Michel SemanInventors: Michel Seman, Suzanne Bernard, Rene Milcent, Catherine Paillat
-
Patent number: 5773014Abstract: Compositions for inhibiting the formation of unwanted skin pigmentation combine high tyrosinase blocking capabilities with stability in cosmetic preparations, absence of significant cytotoxic effects and synergy of action. The active components of the compositions include extracts of certain selected plants, namely, mulberry, saxifrage, grape and scutellaria root; and, preferably, ethylenediaminetetraacetic acid (EDTA). These ingredients are combined with various cosmetically acceptable carriers to produce cream and lotion formulations capable of whitening skin safely and effectively.Type: GrantFiled: October 7, 1996Date of Patent: June 30, 1998Assignee: Bioetica, Inc.Inventors: Eric Perrier, Delphine Rival
-
Patent number: 5763480Abstract: The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.Type: GrantFiled: February 14, 1994Date of Patent: June 9, 1998Assignee: The Jewish Hospital of St. LouisInventors: Paul H. Schlesinger, Steven L. Teitelbaum, Harry C. Blair
-
Patent number: 5677333Abstract: A method for controlling phytopathogenic fungi comprises applying a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of manganese-zinc ethylenebis(dithiocarbamate), manganese ethylenebis(dithiocarbamate), zinc ammoniate ethylenebis(dithiocarbamate), zinc ethylenebis(dithiocarbamate), 2-cyano-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamide, and (E,Z) 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl)morpholine to plant seed, to plant foliage or to a plant growth medium and provides higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: July 8, 1996Date of Patent: October 14, 1997Assignee: Rohm and Haas CompanyInventors: Daniel Louis Loughner, Enrique Luis Michelotti, Willie Joe Wilson, David Hamilton Young
-
Patent number: 5665770Abstract: The invention provides a method for treatment of cataract which comprises administering to a subject in need of such treatment, a radical scavenger in an amount effective in treatment of cataract selected from the group consisting of a reducing thiol derivative, or a disulfide derivative and a sulfide derivative thereof, and a pharmaceutical composition for treatment of cataract which comprises an anti-cataract agent containing a radical scavenger and fine particles, such as emulsions, nanocapsules, alubmin microspheres and liposomes, which carries an anti-cataract agent and has a lipophilic and positively charged phase on the surface thereof.Type: GrantFiled: November 3, 1994Date of Patent: September 9, 1997Assignee: Gakko Hojin Kinki DaigakuInventors: Motome Terao, Yoshimasa Ito
-
Patent number: 5660829Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.Type: GrantFiled: May 16, 1995Date of Patent: August 26, 1997Assignees: Zeneca Limited, Cancer Research Campaign TechnologyInventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger
-
Patent number: 5656615Abstract: This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition contains a 10:1 to 1:10 mixture of (1) N-chlorophenyl carbamates and N-chlorophenylthiocarbamates and (2) N-phosphonoglycine derivatives which are systemic herbicides. This composition can also be used to treat viral infections.Type: GrantFiled: April 12, 1995Date of Patent: August 12, 1997Assignee: The Procter & Gamble CompanyInventor: James Berger Camden
-
Patent number: 5646157Abstract: The present invention relates to a process of disposing obsolete planting seed treated with seed-protectant coatings, especially coatings comprising captan or any of the other widely used compounds such as, for example, pirimiphos-methyl and thiram, alone or in combination with other fungicidally or even insecticidally active compounds, which process comprises subjecting the said plant seed to a compostation.Type: GrantFiled: June 7, 1995Date of Patent: July 8, 1997Assignee: Novartis CorporationInventor: Kaspar J. Hohl
-
Patent number: 5643945Abstract: Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.Type: GrantFiled: June 5, 1995Date of Patent: July 1, 1997Assignee: Bioresearch, Inc.Inventors: Robert J. Kurtz, William D. Fuller
-
Patent number: 5643946Abstract: Compounds of the formula ##STR1## wherein the substituents are as defined herein, are disclosed. Pharmaceutical compositions and methods of treating allergic and inflammatory diseases are also taught.Type: GrantFiled: May 18, 1995Date of Patent: July 1, 1997Assignee: SmithKline Beecham CorporationInventor: Siegfried Benjamin Christensen, IV
-
Patent number: 5633254Abstract: Synergistic mixtures which include dimethomorph and cymoxonil in a fungicidially effective aggregate amount, and the use of such mixtures in the control of plant diseases. In certain embodiments, a contact fungicide is included, along with the dimethomorph and cymoxonil in suitable ratios.Type: GrantFiled: January 11, 1996Date of Patent: May 27, 1997Assignees: Agrogene Ltd., C.T.S. Ltd.Inventor: Yigal Cohen
-
Patent number: 5629341Abstract: This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition is also effective against viruses. The composition contains N-chlorophenylcarbamates and N-chlorophenylthiocarbamates which are systemic herbicides.Type: GrantFiled: April 12, 1995Date of Patent: May 13, 1997Assignee: The Procter & Gamble CompanyInventor: James B. Camden
-
Patent number: 5626883Abstract: A vitamin C supplement comprising ascorbic acid, ascorbyl palmitate, niacinamide ascorbate, calcium ascorbate, magnesium ascorbate, potassium ascorbate, and sodium ascorbate which together can be administered to a human to avoid the transitory initial suppression of human NK cell activity which is present when ascorbic acid alone is administered. Also included is xylitol, lysine acetate, tetrasodium pyrophosphate, ribose, cysteine, and hesperidin which further prolongs the biological activity of ascorbic acid and promotes the uptake of ascorbic acid by human tissue.Type: GrantFiled: April 15, 1994Date of Patent: May 6, 1997Assignee: Metagenics, Inc.Inventor: Stephen M. Paul
-
Patent number: 5607980Abstract: The compositions of the present invention are useful for topical application to human skin. These compositions provide improved skin feel. These compositions can be in the form of leave-on products or products that are rinsed or wiped from the skin after use. These compositions are also useful for conditioning desquamating, and cleansing the skin and for relieving dry skin.Type: GrantFiled: July 24, 1995Date of Patent: March 4, 1997Assignee: The Procter & Gamble CompanyInventors: David M. McAtee, Lourdes D. Albacarys, Erik J. Hasenoehrl, Joseph A. Listro
-
Patent number: 5583089Abstract: This invention provides a dry blend pesticide composition which contains a fungicidal bicarbonate salt ingredient, and a spreader-sticker ingredient which is a crystalline clathrate complex of a urea constituent and a normally liquid spreader sticker constituent such as a nonionic surfactant. In a preferred embodiment all of the composition ingredients are water-soluble, and the composition is readily dispersible in an aqueous medium to form a sprayable pesticide solution.Type: GrantFiled: May 9, 1995Date of Patent: December 10, 1996Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
-
Patent number: 5556880Abstract: The invention provides fungicidal combinations comprising:(a) a compound of formula A ##STR1## wherein each of R.sub.1 and R.sub.2, which are identical or different, is H, Hal or optionally halogenated lower alkyl, and each of R.sub.3 and R.sub.4, which are identical or different, is (C.sub.1 -C.sub.4) alkyl, and(b) at least one compound B selected from the group consisting of maneb, mancozeb, folpet, a copper derivative, phosethyl-Al or phosphorous acid or one of its alkali metal or alkaline-earth metal salts, chlorothalonil, fluazinam, an acylalanine, an acetamide, a methoxyacrylate or a methoxyiminoacetate.Fungicidal compositions comprising the combination and methods for curatively and preventatively treating plants against fungal disease are also provided.Type: GrantFiled: October 14, 1994Date of Patent: September 17, 1996Assignee: Rhone-Poulenc AgrocimieInventor: Marie-Pascale Latorse
-
Patent number: 5550100Abstract: New and improved compositions comprising particulates and an effective amount of manganese chloride to reduce significantly the wetting time and/or the dispersion time of said particulates relative to said time(s) in the absence of said salt(s) have been discovered. Methods for reducing the wetting time of particulates in liquid have also been discovered.Type: GrantFiled: June 6, 1995Date of Patent: August 27, 1996Assignee: Rohm and Haas CompanyInventor: Yili Guo
-
Patent number: 5519062Abstract: Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.Type: GrantFiled: May 23, 1994Date of Patent: May 21, 1996Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: John J. Tegeler, Barbara S. Rauckman, Russell R. L. Hamer, Brian S. Freed, Gregory H. Merriman
-
Patent number: 5516748Abstract: New and improved compositions comprising particulates and an effective amount of one or more effective salt(s) to reduce significantly the wetting time and/or the dispersion time of said particulates relative to said time(s) in the absence of said salt(s) have been discovered. Methods for reducing the wetting time of particulates in liquid have also been discovered.Type: GrantFiled: April 12, 1995Date of Patent: May 14, 1996Assignee: Rohm and Haas CompanyInventor: Yili Guo
-
Patent number: 5504109Abstract: Amino-acid derivatives of the formula ##STR1## in which R.sup.1 represents alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, cycloalkyl, cycloalkenyl, unsubstituted or substituted aryl, unsubstituted or substituted aralkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl,R.sup.2, R.sup.5 are identical or different and represent hydrogen or lower alkyl,R.sup.3, R.sup.4 represent hydrogen, cycloalkyl or alkyl, orR.sup.3 and R.sup.4, together with the carbon atom to which they are bonded, form a cycloalkyl ring,R.sup.6 represents unsubstituted or substituted straight-chain or branched cycloalkylalkyl, unsubstituted or substituted straight-chain or branched cycloalkenyl, alkyl, or alkyl-bridged cycloalkylalkyl.The compounds are useful as pesticidal agents.Type: GrantFiled: November 13, 1992Date of Patent: April 2, 1996Assignee: Bayer AktiengesellschaftInventors: Thomas Seitz, Heinz-Wilhelm Dehne
-
Patent number: 5470586Abstract: A method of controlling the attachment of organisms to an underwater surface is disclosed. The method comprises contacting the organisms with a compound of Formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halogen, or hydroxyl. Antifouling coatings and cementitious compositions containing a compound of Formula I are also disclosed.Type: GrantFiled: April 11, 1994Date of Patent: November 28, 1995Assignee: Duke UniversityInventor: Donald J. Gerhart
-
Patent number: 5432148Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.Type: GrantFiled: December 7, 1994Date of Patent: July 11, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
-
Patent number: 5425952Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.Type: GrantFiled: October 13, 1993Date of Patent: June 20, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
-
Patent number: 5411991Abstract: A method of reducing the rate of mammalian hair growth includes topically applying a composition containing a sulfhydryl reactive compound to the skin.Type: GrantFiled: December 22, 1992Date of Patent: May 2, 1995Inventors: Douglas Shander, Gurpreet S. Ahluwalia, Diana M-D. Grosso
-
Patent number: 5389674Abstract: Novel and improved fungicidal dithiocarbamate particulate compositions comprising one or more components selected from dithiocarbamates and bisdithiocarbamoyl disulfides and an effective amount of moisture content to significantly enhance the flowability of the particulate composition, reduce the dustiness of the composition, increase the bulk density of the composition and/or reduce the ethylenethiourea content of the composition. Methods for producing such particulate compositions are presented wherein controlled slurry production and spray-drying are effective in producing such compositions.Type: GrantFiled: July 12, 1993Date of Patent: February 14, 1995Assignee: Rohm and Haas CompanyInventor: Yili Guo
-
Patent number: 5380747Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.Type: GrantFiled: October 30, 1992Date of Patent: January 10, 1995Assignee: Emory UniversityInventors: Russell M. Medford, Margaret K. Offermann, R. Wayne Alexander
-
Patent number: 5362748Abstract: The subject invention relates to methods for regulating hair growth in mammalian skin comprising topical application of diethyldithiocarbamic acid ("DEDCA") or a pharmaceutically-acceptable salt thereof. The subject invention further involves topical compositions comprising DEDCA.Type: GrantFiled: September 15, 1993Date of Patent: November 8, 1994Assignee: The Procter & Gamble CompanyInventors: Richard J. Schwen, Donald L. Bissett
-
Patent number: 5294430Abstract: A process for preventing or ameliorating the myelosuppression which can occur in a mammal such as a human cancer patient being treated with a platinum-free antineoplastic drug is provided, comprising administering an effective dosage of a dithiocarbamate compound to said mammal, preferably subsequent to administration of the cytotoxic drug.Type: GrantFiled: July 30, 1992Date of Patent: March 15, 1994Assignee: University of RochesterInventors: Richard F. Borch, Therese K. Schmalbach
-
Patent number: 5246954Abstract: The present invention relates to a process for the control of fungal disease of plants by applying to the leaves of the plants:a) 2-(4-chlorobenzylidene)-5,5-diemethyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cy clopentanol;b) one or more fungicides suitable for protecting against the said fungal diseases and to compositions which may be used in the process.Type: GrantFiled: June 13, 1991Date of Patent: September 21, 1993Assignee: Rhone-Poulenc Secteur AgrochimieInventors: Alfred Greiner, Jean Hutt, Jacques Mugnier, Regis Pepin
-
Patent number: 5198012Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.Type: GrantFiled: May 21, 1991Date of Patent: March 30, 1993Assignee: Kao CorporationInventor: Tetsuji Iwasaki
-
Patent number: 5187193Abstract: A process is provided for obtaining one or more bone marrow cell growth factors having granulocyte/macrophage progenitor cell colony stimulating activity, said process comprising: (a) adding to the culture medium of an in vitro, established bone marrow culture a growth factor-stimulating amount of a dithiocarbamate; (b) separating the said dithiocarbamate from the in vitro treated bone marrow culture, adding fresh culture medium to said in vitro treated bone marrow culture, and permitting the concentration of said growth factor or factors to increase in said fresh culture medium; and (c) isolating said growth factor or factors from said fresh culture medium.Type: GrantFiled: March 21, 1991Date of Patent: February 16, 1993Assignee: University of RochesterInventors: Richard F. Borch, Therese K. Schmalbach