With An Additional Active Ingredient Patents (Class 514/479)
  • Publication number: 20020106414
    Abstract: The disclosure is for a capacitor cooled by a heat pipe. The capacitor casing is constructed with an open tube inserted through the casing wall and into which is inserted a simple cylindrical heat pipe. The heat pipe may terminate at the casing wall which then acts as a heat transfer surface, or a portion of the heat pipe which extends beyond the end of the capacitor can be attached to an external heat transfer device, such as a heat conductive mounting plate or a cooling fin assembly.
    Type: Application
    Filed: February 5, 2001
    Publication date: August 8, 2002
    Applicant: Thermal Corp.
    Inventor: Nelson J. Gernert
  • Patent number: 6423726
    Abstract: A composition includes synergistic amounts of: (a) a compound formula (I) wherein X represents ═CH— or ═N—; E represents an electron-withdrawing radical; R represents optionally substituted hetarylalkyl; A represents hydrogen, alkyl, or a bifunctional group which is linked to the radical Z; Z represents alkyl, —NH-alkyl, —N(alkyl)2 or a bifunctional group which is linked to the radical A, and (b) a fungicidal active compound, excluding cyclopropylcarboxamide derivatives and azolylmethylcycloalkanes. The combination of imidacloprid and a fungicidal active compound selected from the group consisting of tebuconazole and compounds of the formula is excluded.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: July 23, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Stefan Dutzmann, Christoph Erdelen, Wolfram Andersch, Heinz-Wilhelm Dehne, Jürgen Hartwig, Klaus Stenzel, Wolfgang Krämer
  • Patent number: 6416789
    Abstract: A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be especially effective in providing resistance to decay, mold and mildew when wood is treated with this combination. Also provided is wood treated by this combination, and a method of treatment for composite wood.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: July 9, 2002
    Assignee: Kop-Coat, Inc.
    Inventors: Brian Marks, Alan S. Ross, Hans A. Ward
  • Patent number: 6414018
    Abstract: Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a &bgr;-blocker are provided, wherein the &bgr;-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: July 2, 2002
    Assignee: Duke University
    Inventor: Francis G. Duhaylongsod
  • Patent number: 6410574
    Abstract: The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide selected from the compounds having a fungicidal activity against plant diseases, and to a method for using the same: wherein R1 is hydrogen, alkyl or cycloalkyl and R2 is CO—Y—R3, wherein Y is O, S, NR4 or the like and R3 is hydrogen, alkyl, phenyl, 5- or 6-membered heterocycle or the like.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: June 25, 2002
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Tsutomu Nishiguchi, Tsuyoshi Takemoto, Sohkichi Tajima, Yoshinobu Yamamoto
  • Patent number: 6384067
    Abstract: 1) Fungicidal compositions comprising a compound (I) which is (4S)-4-methyl-2-methylthio-4-phenyl-1-phenylamino-2-imidazolin-5-one and a compound (II) chosen from the group comprising: (IIA) propamocarb; (IIB) the S-methyl ester of 1,2,3-benzo-thiadiazole-7-carbothioic acid, of formula: (IIC) cyprodinil; (IID) 2-hydroxybenzoic acid or salicylic acid, its esters and its salts, in particular the alkali-metal salts and the alkaline-earth metal salts; the compound (IIF) or 8-t-butyl-2-(N-ethyl -N-n-propylamino)methyl-1,4-dioxaspiro [4.5]decane, also known as spiroxamine; the compound (IIG) or isopropyl ester of [2-methyl-1-(1-p-tolylethylcarbomyl)propyl] acid, also known as fencaramide; the compound (IIH) or 4-chloro-2-cyano-1-dimethylsulphamoyl-5-(4-methylphenyl)imidazole; the compound (I)/compound (II) ratio being between 0.01 and 50, preferably between 0.01 and 10.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: May 7, 2002
    Assignee: Aventis CropScience S.A.
    Inventors: Maurice Chazalet, Marie-Pascale Latorse, Richard Mercer
  • Patent number: 6375727
    Abstract: The present invention provides a composition comprising an amine oxide and an iodine containing biocide. Another embodiment of the present invention is a method for preserving and/or waterproofing a wood substrate by contacting the composition with the wood substrate.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: April 23, 2002
    Assignee: Lonza Inc.
    Inventor: Leigh E. Walker
  • Publication number: 20020041903
    Abstract: A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as promoting hair growth on scalp tissuelacking sufficient hair, restoring normal sexual function in males with erectile dysfunction. Specifically, this is a preparation which provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the scalp or penis. The preparation also contains an agent which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of choline chloride, magnesium chloride and sodium chloride.
    Type: Application
    Filed: September 17, 1997
    Publication date: April 11, 2002
    Inventor: ERIC T. FOSSEL
  • Patent number: 6365613
    Abstract: A fungicidal mixture comprises a.1)a phenyl benzyl ether derivative of the formula I.a, I.b or I.c, or a.2) a carbamate of the formula I.d, where X is CH and N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl and C1-C4-haloalkyl, it being possible for the radicals R to be different if n is 2, or a salt or adduct thereof, and b) a fungicidally active compound from the class of the benzimidazoles or benzimidazole-releasing precursors (II), in a synergistically effective amount.
    Type: Grant
    Filed: November 17, 1999
    Date of Patent: April 2, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Klaus Schelberger, Maria Scherer, Hubert Sauter, Bernd Müller, Erich Birner, Joachim Leyendecker, Manfred Hampel, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann
  • Publication number: 20020035124
    Abstract: This invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr [4-bromo-2-(chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile] in combination with asynergistic amount of at least one of a carbamate-type insecticidal compound.
    Type: Application
    Filed: September 28, 2001
    Publication date: March 21, 2002
    Inventor: Toshiki Fukuchi
  • Patent number: 6358938
    Abstract: Synergistic fungicidal composition comprising propamocarb and a derivative of phosphorous acid; and process for the curative or preventative control of phytopathogenic fungi by use of such a composition.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: March 19, 2002
    Assignee: Rhone-Poulenc Agro
    Inventors: Joëlle Donnadieu, Patrice Duvert, Richard Mercer
  • Patent number: 6355628
    Abstract: Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic platinum coordination complex such as cisplatin.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: March 12, 2002
    Assignee: Tularik Inc.
    Inventors: Susan Schwendner, Pieter Timmermans, Jacqueline Walling
  • Publication number: 20020019428
    Abstract: 1) Fungicidal compositions comprising a compound (I) which is (4S)-4-methyl-2-methylthio-4-phenyl-1-phenylamino-2-imidazolin-5-one and a compound (II) chosen from the group comprising:
    Type: Application
    Filed: September 14, 1999
    Publication date: February 14, 2002
    Inventors: MAURICE CHAZALET, MARIE-PASCALE LATORSE, RICHARD MERCER
  • Patent number: 6342522
    Abstract: A microbiocidal composition including a first component comprises a guanidine compound, a second component which comprises either prochloraz, propiconazole or iodocarb, wherein the weight ratio of first component to second component is in the range of from about 32:1 to about 1:16. The microbiocidal composition provides effective and broader control of micro-organisms in various industrial systems and for household products, agricultural products and biomedical products.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: January 29, 2002
    Inventors: George William Mason, Peter James Hayward, Wallace J Rae, John Doyle
  • Patent number: 6339103
    Abstract: The new compound, dimethy[3-(propoxycarbonylamino)propyl]ammonium O-ethylphosphonate, having fungicidal activity, its preparation, compositions comprising it and methods for its use in agriculture.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: January 15, 2002
    Assignee: Aventis CropScience UK Limited
    Inventors: Norman John De'Ath, John Klostermyer, Albert Schirring, Michael Alan Webb, Geoffrey Gower Briggs
  • Patent number: 6329419
    Abstract: This invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr [4-bromo-2-(chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile] in combination with asynergistic amount of at least one of a carbamate-type insecticidal compound.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: December 11, 2001
    Assignee: American Cyanamid Co.
    Inventor: Toshiki Fukuchi
  • Patent number: 6319949
    Abstract: A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant including a solvent and an emulsifier, wherein the solvent is a mixture of aliphatic hydrocarbons having a distillation range of about 520 to 600° F. and an aromatic content of about 1% or less, or the solvent is a single or combination of C6-C18 fatty alcohol(s); and (b) applying chlorothalonil to the crop previously to, simultaneously with, or subsequently to the application of the aqueous spray composition, wherein phytotoxicity associated with the application of chlorothalonil is reduced or eliminated.
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: November 20, 2001
    Assignee: Syngenta Limited
    Inventors: Jeffrey R. Schussler, Robert E. Moser, Kevin E. Crosby, John R. Washington
  • Patent number: 6290992
    Abstract: A method of termite control consists of injecting a foam formulation above ground into the walls of a structure infested with termites or other undesirable pests. The inner spaces of affected walls are flooded at and above ground level to ensure that the foam formulation reaches all passages open to the soil under the structure and establishes an above-ground layer of pest-control chemicals. The foam penetrates all porous material exposed to the injection and impregnates it with active ingredients that remain embedded in the material long after the foam disappears, thereby retaining the insecticidal, repellant and preservative properties of the active agents for a long time without exposure to normal degrading forces. The pest-control formulation preferably comprises pesticide, repellant and preservative components, and a foaming agent in a liquid carrier.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: September 18, 2001
    Inventor: Shelby J. Magnuson-Hawkins
  • Patent number: 6291516
    Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting a cell with a compound, such as a polypeptide or small molecule in an amount sufficient to control the aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. The present invention further makes available methods and reagents for ameliorating the consequences of hedgehog loss-of-function, ptc gain-of-function, or smoothened loss-of-function comprising contacting a cell with a compound, such as a polypeptide or small molecule, in an amount sufficient to ameliorate the In certain embodiments, the subject compounds, e.g., a cAMP analog, adenylate cyclase agonist, or cAMP phosphodiesterase inhibitor, regulate cAMP levels, which in turn modulates activity of the hedgehog pathway.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: September 18, 2001
    Assignee: Curis, Inc.
    Inventors: Henryk Dudek, Benxiu Ji
  • Patent number: 6277880
    Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: August 21, 2001
    Assignees: Zeneca Limited, Cancer Research Campaign Technology Limited
    Inventors: Philip John Burke, Robert Ian Dowell, Anthony Brian Mauger, Caroline Joy Springer
  • Publication number: 20010006964
    Abstract: New active compound combinations of valinamide derivatives of the formula (I) 1
    Type: Application
    Filed: February 5, 2001
    Publication date: July 5, 2001
    Inventors: Heinz-Wilhelm Dehne, Wilhelm Brandes, Karl-Heinz Kuck, Thomas Seitz
  • Patent number: 6251870
    Abstract: This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition contains N-chlorophenylcarbamates and N-chlorophenylthiocarbamates along with a chemotherapeutic agent and optionally a potentiator. A composition for treating viral infections in animals or humans comprising a safe and effective amount of N-chlorophenylcarbamates and the N-chlorophenylthiocarbamates and a potentiator is also disclosed.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: June 26, 2001
    Assignee: The Procter & Gamble Company
    Inventor: James Berger Camden
  • Patent number: 6245772
    Abstract: New active compound combinations of valinamide derivatives of the formula (I) in which R1 and R2 has the meaning given in the description, with known fungicidal active substances, and their use for combating phytopathogenic fungi are described.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: June 12, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Wilhelm Dehne, Wilhelm Brandes, Karl-Heinz Kuck, Thomas Seitz
  • Patent number: 6228883
    Abstract: A method for combatting plant fungi in a plant, which comprises applying to the seeds or tubers of the plant, an effective amount of a fungicidal composition comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, optionally in admixture with one or both of an alkylene bis-dithiocarbamate complex salt and a thiophanate compound. Fungicidal compositions comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, an alkylene bis-dithiocarbamate complex salt, and a thiophanate compound, are also described.
    Type: Grant
    Filed: August 12, 1998
    Date of Patent: May 8, 2001
    Assignee: Gustafson, Inc.
    Inventor: Jennifer Lynn Riggs
  • Patent number: 6221896
    Abstract: This invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more compounds selected from the group consisting of benzoepin, nereistoxin-type insecticidal agents and diafenthiuron.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: April 24, 2001
    Assignee: American Cyanamid Co.
    Inventor: Toshiki Fukuchi
  • Patent number: 6211228
    Abstract: Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: April 3, 2001
    Assignee: Axys Pharmaceuticals, Inc
    Inventors: Ken Duane Rice, Jeffrey Mark Dener, Anthony Robert Gangloff, Elaine Yee-Lin Kuo
  • Patent number: 6197805
    Abstract: This invention is directed to a broad spectrum antimicrobial composition which comprises a mixture of an iodopropynyl compound in combination with 2-(methoxycarbonylamino)benzimidazole and, where desirable, an algicide said mixture provided in an amount sufficient to protect a substrate from attack by one or more organisms. The composition can be used broadly in industrial systems and more particularly with substrates such as paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, caulking, sealants, textiles, leather, wood, preservatives, metal working fluids, drilling muds, clay slurries, glazes, optical brightness, carpet backing, pigments and as a preservative for other aqueous and wet state products, and the like.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: March 6, 2001
    Assignee: Troy Technology Corporation, Inc.
    Inventor: Roger Errol Smith
  • Patent number: 6159977
    Abstract: A therapeutic solution and application procedure for curing Nail fungus infections or Onychomycosis comprising a combination of an anti-fungal agent with DMSO in a anhydrous solution of Polyglycol, and including a secondary anti-inflammatory agent. The DMSO acts as a delivery vehicle so that active anti-fungal agents such as Miconazole in combination with an anti-inflammatory compound such as ibuprofen can be delivered directly to fungal infected areas under and around the nail. The DMSO, Miconazole, and ibuprofen are dissolved in a viscous solution of Polyglycol so that the combined ingredients may be applied directly to the affected nails with superior penetration. The therapeutic solution is formulated by dissolving the Miconazole into the Polyglycol over heat and adding the ibuprofen and DMSO over additional heat in a timed process.
    Type: Grant
    Filed: November 16, 1998
    Date of Patent: December 12, 2000
    Assignee: Astan, Inc.
    Inventor: Stanley Forrest Reeves
  • Patent number: 6156778
    Abstract: This invention relates to a composition for controlling harmful fungi comprising, in a solid or liquid carrier,a) at least one carbamate of the formula I ##STR1## where X is CH or N andthe radicals R.sup.a and R.sup.b independently of one another are a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 -alkyl or a C.sub.1 -C.sub.4 -haloalkyl group; andb) at least one valine amide of the formula II ##STR2## where R.sup.1 is C.sub.3 -C.sub.4 -alkyl andR.sup.2 is naphthyl or phenyl, the phenyl radical being substituted in the 4-position by a halogen atom, a C.sub.1 -C.sub.4 -alkyl group or C.sub.1 -C.sub.4 -alkoxy group.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: December 5, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Ruth Muller, Herbert Bayer, Hubert Sauter, Karl Eicken, Frank Wetterich, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann, Maria Scherer, Klaus Schelberger, Bernd Muller, Joachim Leyendecker
  • Patent number: 6127410
    Abstract: Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: October 3, 2000
    Assignee: Duke University
    Inventor: Francis G. Duhaylongsod
  • Patent number: 6127411
    Abstract: A method for combatting plant fungi in a plant, which comprises applying to the seeds or tubers of the plant, an effective amount of a fungicidal composition comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, optionally in admixture with one or both of an alkylene bis-dithiocarbamate complex salt and a thiophanate compound. Fungicidal compositions comprising a fungicidally effective amount of a 2-alkoxyimino-acetamide compound, an alkylene bis-dithiocarbamate complex salt, and a thiophanate compound, are also described.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: October 3, 2000
    Assignee: Gustafson, Inc.
    Inventor: Jennifer Lynn Riggs
  • Patent number: 6124350
    Abstract: This invention is directed to a method for stabilizing a composition which comprises a mixture of a halopropargyl compound. The composition can be used broadly in industrial systems and more particularly with substrates such as paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, caulking, sealants, textiles, and the like.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: September 26, 2000
    Assignee: Troy Technology Corporation, Inc.
    Inventors: Kamlesh D. Gaglani, Eeva-Liisa Kuusisto, John Hansen, Ismael Colon
  • Patent number: 6121198
    Abstract: The invention is directed to a biocidal composition for inhibition fungal, bacterial and algae growth which comprises a mixture of tetrachloroisophthalonitrile and 3-iodo-2-propynly butyl carbamate.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: September 19, 2000
    Assignee: Creanova Inc.
    Inventors: Karen Winkowski, Techen Tsao
  • Patent number: 6121232
    Abstract: A stabilized solution of fibrinogen containing samples, in particular a stabilized solution of the biological active component (BAC) which is a solution of proteins derived from blood plasma comprising fibrinogen, tranexamic acid and arginine or lysine or mixtures or arginine and lysine, their pharmaceutically acceptable salts, as well as, optionally, substances forming a buffered solution in aqueous medium.
    Type: Grant
    Filed: February 10, 1997
    Date of Patent: September 19, 2000
    Assignee: Omrix Biopharmaceuticals SA
    Inventors: Israel Nur, Lilliana Bar, Oded Lieberman
  • Patent number: 6114347
    Abstract: A pharmaceutical formulation for the prophylaxis and preliminary treatment of a poisoning caused by organophosphorus cholinesterase inhibitors is characterized in that it consists of an active substance combination of at least one parasympathomimetic and at least one parasympatholytic.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: September 5, 2000
    Assignees: LTS Lohmann Therapie-Systeme GmbH, Israel Institute for Biological Research
    Inventors: Thomas Hille, Walter Muller, Bodo Asmussen, Aharon Levy, Yacov Meshulam
  • Patent number: 6103768
    Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: August 15, 2000
    Assignee: Mycogen Corporation
    Inventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
  • Patent number: 6087394
    Abstract: Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: July 11, 2000
    Assignee: Duke University
    Inventor: Francis G. Duhaylongsod
  • Patent number: 6075047
    Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: June 13, 2000
    Assignee: Rohm and Haas Company
    Inventors: David Hamilton Young, Willie Joe Wilson, Anne Ritchie Egan, Enrique Luis Michelotti
  • Patent number: 6060489
    Abstract: The present invention relates to insecticidal mixtures of chloronicotinyl insecticides of the formula (I) ##STR1## in which R.sup.1 represents C.sub.1 -C.sub.5 -alkyl,R.sup.2 represents hydrogen or C.sub.1 -C.sub.5 -alkylorR.sup.1 and R.sup.2 together represent --CH.sub.2 --CH.sub.2 --; --CH.sub.2 --CH.sub.2 --CH.sub.2 -- or ##STR2## X represents an NH group, NCH.sub.3 group or represents sulphur, Y represents nitrogen or a CH group andZ represents cyano or nitro,with one or more of the synergists mentioned in the description.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: May 9, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christoph Erdelen, Wolfgang Kramer, Kai-Uwe Bruggen
  • Patent number: 6057363
    Abstract: New active compound combinations of valinamide derivatives of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 has the meaning given in the description,with known fungicidal active substances, and their use for combating phytopathogenic fungi are described.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: May 2, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz-Wilhelm Dehne, Wilhelm Brandes, Karl-Heinz Kuck, Thomas Seitz
  • Patent number: 6040339
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR2## wherein: A.sup.1 is a single bond, alkylene or alkenylene; A.sup.2 is or alkenylene; A.sup.3 is a single bond, alkyleneor alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or various other groups; R.sup.6 is alkyl or phenyl; R.sup.7 is hydrogen or alkyl; R.sup.8 is alkyl or various other groups; and n is 0 and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: March 21, 2000
    Assignee: Sankyo Company, Limited
    Inventors: Akira Yoshida, Kozo Oda, Takashi Kasai, Kousei Shimada, Hiroshi Kogen, Ichiro Hayakawa, Sadao Ishihara, Teiichiro Koga, Eiichi Kitazawa, Taro Tokui
  • Patent number: 6034081
    Abstract: A method for increasing the effectiveness of a microbicide is described, wherein a microbicide and an N-alkyl heterocyclic compound are applied to a substrate or aqueous system subject to the growth of microorganisms. The N-alkyl heterocyclic compound is applied in an amount effective to increase the microbicidal activity of the microbicide. The N-alkyl heterocyclic compound has the formula: ##STR1## The variable "In" ranges from 5 to 17, and the heterocyclic ring defined by ##STR2## is a substituted or unsubstituted ring having four to eight members. Microbicidal compositions are described where the microbicide and the N-alkyl heterocyclic compound are present in a combined amount effective to control the growth of at least one microorganism. Methods for controlling the growth of microorganisms on various substrates and in various aqueous systems are also described.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: March 7, 2000
    Assignee: Buckman Laboratories International Inc
    Inventors: Marilyn S. Whittemore, Daniel E. Glover, S. Rao Rayudu
  • Patent number: 6034135
    Abstract: The present invention provides novel dimeric cationic lipids. The present invention further provides compositions of these lipids with anionic or polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: March 7, 2000
    Assignee: Promega Biosciences, Inc.
    Inventors: David Aaron Schwartz, Brian Patrick Dwyer, William J. Daily, Kumar Srinivasan, Bob Dale Brown
  • Patent number: 6028093
    Abstract: Fungicidal mixtures, comprisinga) a carbamate of the formula I ##STR1## where T is CH or N, n is 0, 1 or 2 and R is halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -haloalkyl, it being possible for the radicals R to be different when n is 2, and/orb) an oxime ether of the formula II, ##STR2## where the substituents have the following meanings: X is oxygen or amino;Y is CH or N;Z is oxygen, sulfur, amino or C.sub.1 -C.sub.4 -alkylaminoR' is C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -haloalkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.3 -C.sub.6 -haloalkynyl, C.sub.3 -C.sub.6 -cycloalkyl-methyl, or is benzyl which can be partially or fully halogenated and/or can have attached to it one to three of the following radicals: cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy and C.sub.1 -C.sub.4 -alkylthio; andc) a carbamate of the formula III(CH.sub.3).sub.2 N--CH.sub.2 CH.sub.2 CH.sub.
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: February 22, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Muller, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann, Klaus Schelberger, Maria Scherer, Dietrich Mappes, Joachim Leyendecker, Herbert Bayer, Ruth Muller
  • Patent number: 6017955
    Abstract: This invention is directed to a method for stabilizing a composition which comprises a mixture of a halopropargyl compound. The composition can be used broadly in industrial systems and more particularly with substrates such as paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, caulking, sealants, textiles, and the like.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: January 25, 2000
    Assignee: Troy Technology Corporation, Inc.
    Inventors: Kamlesh Gaglani, Eeva-Liisa Kuusisto, John Hansen, Ismael Colon
  • Patent number: 5990143
    Abstract: New microbicidal, optionally solvent- and emulsifier-free microbicidal active compound combinations and agents comprising known azole fungicides and quaternary ammonium compounds and their use in the preservation of materials.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: November 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Georg-Wilhelm Ludwig, Otto Exner, Karl-Heinz Buchel, Graham Holmwood
  • Patent number: 5972324
    Abstract: The present invention relates to a dimeric urethane compounds derived from monohydric alcohols, generally fatty alcohols, and a diisocyanate according to the following reaction scheme: ##STR1## wherein R.sub.1 is selected from the group of saturated or halogen substituted linear, cyclic or branch-chained hydrocarbons and R.sub.2 is a linear, cyclic or branch-chained alkyl or aminoalkyl group ranging from two to 200 carbon atoms, preferably two to 50 carbons, more preferably 6 to 36 carbons, said urethane compound being substantially free from terminal hydroxyl groups.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: October 26, 1999
    Assignee: Alzo, Inco.
    Inventors: Albert Zofchak, Madeline Kenney, John Obeji, Michael Mosquera
  • Patent number: 5965594
    Abstract: Improved liquid antimicrobial solutions useful as preservative additives to personal care preparations, particularly cosmetic formulations and the like, are provided which comprise 1,3-dimethylol-5,5-disubstituted hydantoin, liquid aromatic alcohol, and iodoalkynyl alkyl carbamate. A preferred antimicrobial solution can be prepared by producing the 1,3,dimethylol-5,5-disubstituted hydantoin in situ in the selected liquid aromatic alcohol and then adding to the resulting solution the previously prepared iodoalkynyl alkyl carbamate. The solutions are surprisingly water dispersible and display broad spectrum antimicrobial effectiveness, particularly antifungal effectiveness, at a relatively low usage concentration in a cosmetic medium.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: October 12, 1999
    Assignee: McIntyre Group, Ltd.
    Inventors: Thomas G. Schoenberg, Richard J. Otterson, Dennis Abbeduto
  • Patent number: 5948730
    Abstract: This invention is directed to a broad spectrum fungicide/algaecide composition which comprises a mixture of (a) at least one halopropynyl compound and (b) at least one sulfur-containing s-triazine, said mixture provided in an amount to prevent and/or protect a substrate from attack by one or more fungal and/or algael organisms. The composition can be used broadly in industrial systems and more particularly with substrates such as paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, caulking, sealants, textiles, and the like.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: September 7, 1999
    Assignee: Troy Chemical Corporation
    Inventors: Eeva-Liisa Kuusisto, Kurt Hansen
  • Patent number: 5939357
    Abstract: This invention provides a novel fungicide composition which has a bicarbonate-containing inorganic salt ingredient which enhances the efficacy of a fungicide ingredient for the treatment of cultivated crops. An invention fungicide composition also contains a surfactant ingredient, and a water-soluble organic compound which functions as a compatibility enhancing ingredient in aqueous formulations, and the ingredients improve the spreadability and adhesiveness of the composition when applied to foliage. An invention fungicide composition also contains a fertilizer-effective ratio of nitrogen, phosphorus and potassium.
    Type: Grant
    Filed: June 7, 1993
    Date of Patent: August 17, 1999
    Assignee: Church & Dwight Co., Inc.
    Inventors: Keith A. Jones, Anthony E. Winston, M. Stephen Lajoie, Amy L. Joseph