Carbon Bonded To -ncx Or -xcn (e.g., Cyanate, Thiocyanate Or Isothiocyanate, Etc.) (x Is Chalcogen) Patents (Class 514/514)
  • Patent number: 10098871
    Abstract: Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: October 16, 2018
    Inventors: Leslie B. Gordon, Mark W. Kieran, Monica E. Kleinman
  • Patent number: 9771322
    Abstract: A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: September 26, 2017
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Patent number: 9655875
    Abstract: A method of treating or preventing human or mammalian cancer and tumor including administering to a patient or an animal in need thereof a pharmaceutical composition, a health product, or a food additive, including 1-(alkylsulfinyl)-2-isothiocyanatoalkyl-1-alkene.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: May 23, 2017
    Assignee: BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY
    Inventors: Qipeng Yuan, Ming Yang, Hao Liang
  • Patent number: 9603827
    Abstract: Provided is a novel method for preventing and/or treating hairy wart disease which is a hoof and leg disease of ungulates. The method is carried out by administering an isothiocyanic acid ester such as allyl isothiocyanate to a hoof of an ungulate. Examples of ungulates targeted for application of the present invention include cows such as dairy cows as well as sheep, pigs and horses.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: March 28, 2017
    Assignees: MITSUBISHI-KAGAKU FOODS CORPORATION, INCORPORATED NATIONAL UNIVERSITY IWATE UNIVERSITY
    Inventors: Keiji Okada, Yasushi Sekiyama
  • Patent number: 9567405
    Abstract: The present invention relates to a method of synthesizing sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesizing a stabilized complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: February 14, 2017
    Assignee: PharmAgra Labs, Inc.
    Inventors: Sahadeva Reddy Damireddi, Kpakpo Ambroise Akue, Jared K. Nelson, Albert Roger Frisbee, Peter Wyatt Newsome
  • Patent number: 9505784
    Abstract: The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: November 29, 2016
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Hwan Geun Choi, Taebo Sim, Nathanael Gray, Wenjun Zhou, Jae Won Chang, Jianming Zhang, Ellen Weisberg
  • Patent number: 9393225
    Abstract: Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral administration of sulforaphane to subjects indicated to be at risk due to factor(s) such as medical history of atypical nevi, melanoma, or UV exposure. Sulforaphane can be administered orally as a safe and well-tolerated natural agent as a chemopreventive strategy in individuals with atypical melanocytic nevi.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: July 19, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Jan H. Beumer, John M. Kirkwood, Shivendra V. Singh, Charles K. Brown
  • Patent number: 9308192
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: April 12, 2016
    Assignee: The Johns Hopkins University
    Inventors: Pierre A. Coulombe, Michelle L. Kerns
  • Publication number: 20150141507
    Abstract: Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral administration of sulforaphane to subjects indicated to be at risk due to factor(s) such as medical history of atypical nevi, melanoma, or UV exposure. Sulforaphane can be administered orally as a safe and well-tolerated natural agent as a chemopreventive strategy in individuals with atypical melanocytic nevi.
    Type: Application
    Filed: May 3, 2013
    Publication date: May 21, 2015
    Inventors: Jan H. Beumer, John M. Kirkwood, Shivendra V. Singh, Charles K. Brown
  • Publication number: 20150126600
    Abstract: A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Inventor: Michael E. Silver
  • Publication number: 20150126437
    Abstract: The disclosure provides compounds useful as insect repellents, compositions comprising such repellents, and methods of repelling an arthropod using such compounds and compositions. The disclosure further provides insect traps and method for identifying ligands and cognates for biological molecules.
    Type: Application
    Filed: October 17, 2012
    Publication date: May 7, 2015
    Applicant: The Regents of the University of California
    Inventors: Anandasankar Ray, Sean Michael Boyle
  • Publication number: 20150110863
    Abstract: The present invention relates to a new series of compounds having general formula (I) and the optical isomer or enantiomer forms thereof, which belong to the family of sulforaphane derivatives. The invention also relates to the production method thereof. The invention further relates to the multiple medical (pharmaceutical, homeopathic and phytotherapeutic), food, cosmetic and dietary uses of said series of compounds, especially the use thereof in the prevention and/or treatment of diseases and any type of illness or damage associated with an oxidative process or which, although not involved in said process, are mediated by the Nrf2 transcription factor, such as, for example, cancer. The compounds can be used alone or, alternatively, encapsulated in cyclodextrins.
    Type: Application
    Filed: March 6, 2013
    Publication date: April 23, 2015
    Applicants: Univerversidad De Sevilla, Consejo Superior De Investigaciones CientÍficas (CSIC)
    Inventors: Noureddine Khiar El Wahabi, Inmaculada Fernández Fernández, Rocío Recio Jiménez
  • Patent number: 8987316
    Abstract: The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: March 24, 2015
    Assignee: DoubleHill GmbH
    Inventor: Jochen Kalbe
  • Publication number: 20150080294
    Abstract: The invention provides methods for treating obesity in a subject comprising administering an effective amount of catestatin (CST) or its equivalent to a subject afflicted with obesity so as to maintain an effective amount of circulating catestatin in the subject to promote lipolysis and oxidation of released fatty acids in both liver and adipose tissue, thereby, reducing adipose tissue weight and hence treating obesity in the afflicted subject.
    Type: Application
    Filed: April 1, 2013
    Publication date: March 19, 2015
    Inventors: Sushil K. Mahata, Gautam K. Bandyopadhyay
  • Publication number: 20150065431
    Abstract: The present invention provides methods of reducing cutaneous scar formation by treating a cutaneous wound with a composition comprising a therapeutic agent that is a sodium channel blocker and/or an inhibitor of the Nax/SCN7A pathway. The present invention also provides wound cover components impregnated with such compositions, kits composed of such compositions with a wound dressing or sterile wipe, and mixtures of such compositions with a topical component (e.g., cream, ointment, or gel) suitable for application to a cutaneous wound. The present invention also provides compositions, kits, devices, and methods for treating skin conditions (e.g., dermatitis, psoriasis, or other skin conditions) with such compositions and devices. Examples of such therapeutic agents include, but are not limited to, an inhibitor of a gene or protein selected from: ENac, COX-2, PGE2, PI3K, PKB, Nax Prss8, IL-1?, IL-8, SAPK, Erk gene, p38 gene, PAR2, S100A8, S100A9, S100A12.
    Type: Application
    Filed: August 27, 2014
    Publication date: March 5, 2015
    Inventors: Wei Xu, Seok Jong Hong, Robert D. Galiano, Thomas A. Mustoe
  • Publication number: 20150038580
    Abstract: A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Application
    Filed: October 21, 2014
    Publication date: February 5, 2015
    Inventor: Michael E. Silver
  • Publication number: 20150038579
    Abstract: A method for treating eczema including the steps of applying an isothiocyanate functional surfactant to an area affected by eczema, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Application
    Filed: October 21, 2014
    Publication date: February 5, 2015
    Inventor: Michael E. Silver
  • Patent number: 8937050
    Abstract: Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: January 20, 2015
    Assignees: The Johns Hopkins University, Kennedy Krieger Institute, Inc.
    Inventors: Paul Talalay, Andrew W. Zimmerman, Kirby D. Smith
  • Patent number: 8933119
    Abstract: A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis, wherein said isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: January 13, 2015
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Publication number: 20140364317
    Abstract: The present invention relates to a method for a preparation of a solid composition comprising the steps of a) dissolving a premix in a premix-solvent, or melting a premix, wherein the premix contains a pesticide and a nonionic, amphiphilic polyalkoxylate, b) solidifying the premix by removing the premix-solvent, or by cooling, and c) contacting the premix with at least one auxiliary. The invention further relates to a solid composition obtainable by said method; to a method for the preparation of an aqueous tank mix, in which a pesticide is present as suspended particles having a particle size below 1.
    Type: Application
    Filed: November 29, 2012
    Publication date: December 11, 2014
    Applicant: BASF SE
    Inventors: Claude Taranta, Thomas Bork, Jochen Schreieck, Helmut Müller, Nadine Riediger, Clark D. Klein, Rebecca Willis, Tatjana Sikuljak, Murat Mertoglu
  • Publication number: 20140322304
    Abstract: Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described herein.
    Type: Application
    Filed: July 10, 2014
    Publication date: October 30, 2014
    Inventors: Gavin P. Robertson, Raghavendra Gowda Chandagalu D., Subbarao V. Madhunapantula, Gajanan S. Inamdar, Omer F. Kuzu
  • Patent number: 8865765
    Abstract: A method for treating eczema including the steps of applying an isothiocyanate functional surfactant to an area affected by eczema, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: October 21, 2014
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Publication number: 20140243267
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers.
    Type: Application
    Filed: September 12, 2013
    Publication date: August 28, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Pierre A. Coulombe, Michelle L. Kerns
  • Publication number: 20140228419
    Abstract: The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.
    Type: Application
    Filed: September 18, 2012
    Publication date: August 14, 2014
    Applicant: DoubleHill GmbH
    Inventors: Jochen Kalbe, Olaf Hansen
  • Publication number: 20140221316
    Abstract: This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
    Type: Application
    Filed: August 15, 2012
    Publication date: August 7, 2014
    Applicant: RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
    Inventors: Khosrow Kashfi, Ravinder Kodela
  • Patent number: 8691870
    Abstract: Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: April 8, 2014
    Assignee: Mackay Memorial Hospital
    Inventors: Yu-Jen Chen, Hui-Fen Liao
  • Publication number: 20140080795
    Abstract: Methods for the treatment or prevention of diseases which are caused by the decreased concentrations of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by the methods of the invention include chronic obstructive pulmonary disease (COPD) and asthma, including steroid resistant COPD and asthma. The invention provides methods for treating or preventing of diseases caused by the degradation of HDAC2 by providing to the subject in need of treatment or prevention a molecular compound capable of preventing the degradation of HDAC2. Such molecular compounds include Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activators. Methods are further provided for the treatment and prevention of COPD and asthma by providing to a subject in need of such treatment and prevention a nucleic acid which causes expression of HDAC2 in lung cells and/or a nucleic acid which causes expression of Nrf2 in lung cells.
    Type: Application
    Filed: November 18, 2011
    Publication date: March 20, 2014
    Applicant: University of Rochester
    Inventor: Irfan Rahman
  • Publication number: 20130288985
    Abstract: This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.
    Type: Application
    Filed: June 30, 2011
    Publication date: October 31, 2013
    Applicant: The Schepens Eye Research Institute Inc.
    Inventor: Ula V. Jurkunas
  • Publication number: 20130253052
    Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 26, 2013
    Applicant: The Penn State Research Foundation
    Inventors: Gavin P. Robertson, Arati K. Sharma, Arun K. Sharma, Shantu G. Amin, Dhimant H. Desai
  • Publication number: 20130237423
    Abstract: An agricultural chemical composition comprises a solvent having the general formula CO(ORa)(Rb), wherein Ra is a linear or branched alkyl group of one to eight carbon atoms and Rb is an aromatic group. Active agricultural components are dissolved in the solvent to produce a solution usable for distributing the active components.
    Type: Application
    Filed: November 29, 2011
    Publication date: September 12, 2013
    Applicant: Hunstman Petrochemical LLC
    Inventor: Dave C. Ferguson
  • Publication number: 20130231387
    Abstract: The invention concerns the role of Glo 1 in the prevention and reversal of proteomic and genomic damage by carbonyl substrates thereof and, in particular, therapeutics that promote Glo 1 production.
    Type: Application
    Filed: June 20, 2011
    Publication date: September 5, 2013
    Applicant: THE UNIVERSITY OF WARWICK
    Inventors: Mingzhan Xue, Paul Thornalley, Naila Rabbani
  • Publication number: 20130184339
    Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 18, 2013
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventor: The Penn State Research Foundation
  • Publication number: 20130184340
    Abstract: Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
    Type: Application
    Filed: March 5, 2013
    Publication date: July 18, 2013
    Inventor: The Penn State Research Foundation
  • Publication number: 20130157965
    Abstract: The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
    Type: Application
    Filed: November 6, 2012
    Publication date: June 20, 2013
    Applicant: Brassica Foundation for ChemoProtection Research..
    Inventor: Brassica Foundation for ChemoProtection Resear
  • Publication number: 20130158111
    Abstract: The invention is directed towards methods of treating abnormal tissues in a subject or sensitizing an abnormal tissue to a chemotherapeutic agent. The methods comprise screening at least a portion of an abnormal tissue for at least one mutant form of p53 protein, and administering at least one isothiocyanate (ITC) to the subject or abnormal tissue if the abnormal tissue is positive for the at least one mutant form of p53.
    Type: Application
    Filed: December 20, 2012
    Publication date: June 20, 2013
    Applicant: Georgetown University
    Inventor: Georgetown University
  • Publication number: 20130143962
    Abstract: The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 6, 2013
    Applicant: WOMEN & INFANTS' HOSPITAL OF RHODE ISLAND
    Inventor: Women & Infants' Hospital of Rhode Island
  • Publication number: 20130142739
    Abstract: A method for synthesizing an isothiocyanate of general formula (I) SCN—R1—R4—R2??(I) wherein R1 and R2 represent independently of each other an alkyl-aryl or aryl group, R4 represents a carbonyl, sulfinyl, sulfonyl group or a sulfide group and of its derivatives comprising a step for reacting an alkylalkylamine having the general formula (II) NH2—R1—R4—R2??(II) wherein R1 and R2 represent independently of each other an alkyl, aryl or alkylaryl group, R4 represents a carbonyl, sulfinyl, sulfonyl or sulfide group, in the presence of carbon sulfide and of di-tert-butyl dicarbonate with formation of the corresponding aforesaid isothiocyanate, compounds obtained by this method as well as their uses.
    Type: Application
    Filed: July 20, 2011
    Publication date: June 6, 2013
    Applicant: Auriga International
    Inventors: Jacques Dubois, Alfred Marchal, Damien Lacroix, Jérôme Cabou
  • Publication number: 20130143963
    Abstract: A stable galenic composition of a compound of general formula (I) wherein R1 and R2 both represent independently of each other an alkyl, aryl, arylalkyl group, optionally substituted with one or more linear or branched groups, optionally bearing one or more heteroatoms, comprising said compound of formula I in an amount ranging from 0.01 to 15% by weight based on the total weight of the final composition; at least one anhydrous ester, the main chain and/or optionally the branched chains of which are free from free and/or reactive groups or functions, in an amount ranging from 0.1 to 99.9% by weight based on the total weight of the cosmetically and pharmaceutically acceptable composition; and optionally a cosmetically and pharmaceutically acceptable excipient for completing the 100% of the total weight of the composition.
    Type: Application
    Filed: July 19, 2011
    Publication date: June 6, 2013
    Applicant: Auriga International
    Inventors: Jacques Dubois, Alfred Marchal, Damien Lacroix, Jérôme Cabou
  • Publication number: 20130129809
    Abstract: The invention relates to compositions and methods for treating cancer comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, methods of inhibiting the growth of cancer stem cells or tumor initiating cell comprising administering to a subject in need a pharmaceutically effective dose of a cancer stem cell inhibitor, and methods of enhancing the biological effects of chemotherapeutic drugs or irradiation on cancer cells comprising administering to a subject in need a pharmaceutically effective dose of a chemotherapeutic drug and a pharmaceutically effective dose of a cancer stem cell inhibitor.
    Type: Application
    Filed: May 21, 2012
    Publication date: May 23, 2013
    Applicant: Glax L.L.C.
    Inventors: Rakesh K. Srivastava, Sharmila Shankar
  • Publication number: 20130123203
    Abstract: Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder.
    Type: Application
    Filed: October 31, 2012
    Publication date: May 16, 2013
    Inventors: Paul Talalay, Andrew W. Zimmerman, Kirby D. Smith
  • Patent number: 8440622
    Abstract: The invention relates to the use of gelsolin to treat neurologic diseases (e.g., multiple sclerosis) and to the use of gelsolin to diagnose, monitor, and evaluate therapies of neurologic diseases.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: May 14, 2013
    Assignees: The Brigham and Women's Hospital, Inc., BloodCenter Research Foundation, Inc.
    Inventors: Thomas P. Stossel, Po-Shun Lee, Bonnie Dittel, Katarzyna Maresz
  • Patent number: 8410170
    Abstract: A method for preventing and treating prostatic diseases and skin cancer using naturally or artificially synthesized isothiocyanates compounds or the derivatives or metabolites thereof.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: April 2, 2013
    Assignee: Wuxi JC Pharmaceutical Technology Co., Ltd.
    Inventors: Jingcai Cheng, Jenwei Chiao, Haiya Jin, Chengjuan Zhong
  • Publication number: 20130079401
    Abstract: Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 28, 2013
    Inventors: Yu-Jen CHEN, Hui-Fen Liao
  • USE
    Publication number: 20130053332
    Abstract: The present invention relates to a composition comprising a high glucosinolate Cruciferous vegetable (such as a high glucosinolate broccoli) having a high level of glucosinolate and/or at least one derivative thereof for use in the treatment or prevention of a cardiovascular disease or for use in promoting heart and/or cardiovascular health.
    Type: Application
    Filed: December 23, 2010
    Publication date: February 28, 2013
    Applicant: PLANT BIOSCIENCE LIMITED
    Inventor: Richard Mithen
  • Publication number: 20130039928
    Abstract: The present invention features methods for reversing corticosteroid resistance, as well as for the treatment of respiratory infections, particularly those associated with chronic obstructive pulmonary disease. In one embodiment, the method increases Nrf2 biological activity or expression.
    Type: Application
    Filed: January 28, 2011
    Publication date: February 14, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Shyam Biswal, Rajesh K. Thimmulappa
  • Publication number: 20130039856
    Abstract: The present invention concerns medicaments for slowing ageing. The medicaments can include an inhibitor of microbial folate biosynthesis as well as agents capable of reducing folate uptake by an animal. Examples of such medicaments include inhibitors that reduce the activity of an enzyme in the folate biosynthesis pathway, such as sulfonamides including sulfamethoxazole. The invention also concerns a food supplement, additive, functional food, or nutraceutial comprising the inhibitor or agent or composition as discussed above, as well as methods for screening for an agent for use as a medicament for slowing ageing comprising determining whether a test agent inhibits microbial folate biosynthesis, or whether the test agent reduces folate uptake by a non-human animal.
    Type: Application
    Filed: February 25, 2011
    Publication date: February 14, 2013
    Applicant: University of Durham
    Inventor: David Weinkove
  • Publication number: 20130035304
    Abstract: This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: January 31, 2011
    Publication date: February 7, 2013
    Inventors: Loren D. Walensky, Michelle L. Stewart, Nicole Cohen
  • Publication number: 20130004477
    Abstract: This invention provides compositions and methods for treating inflammation related diseases. Particularly, the present invention provides methods and compositions of administering thiocyanate to treat inflammation related diseases, such as cystic fibrosis, lung disease, lung cancer, asthma, bronchitis, pancreatic disease, digestive track disease, diabetes, neurological disorder, cardio-vascular disease, atherosclerosis, arthritis, nephritis, or stroke, and neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, or autism. The invention provides the use of thiocyanate to diagnose inflammation related diseases.
    Type: Application
    Filed: October 22, 2010
    Publication date: January 3, 2013
    Inventors: Zhe Lu, Yanping Xu
  • Publication number: 20120309808
    Abstract: Provided herein are pharmaceutical compositions and methods for treating disorders characterized by reduced expression of anti-oxidative stress enzymes in a subject. In one aspect, the present invention provides a method for inducing expression of anti-oxidative stress enzymes in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a demethylating agent. The demethylating agent includes a phytochemical that induces expression of Nrf2 and Nrf2-mediated genes expressing anti-oxidative stress. Such phytochemicals include indoles, such as 3,3?-diindolylmethane (DIM) and indole-3-carbinol (I3C), and isothiocyanates, such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).
    Type: Application
    Filed: May 31, 2012
    Publication date: December 6, 2012
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Ah-Ng T. Kong
  • Publication number: 20120288550
    Abstract: A method of treating a surface of a substrate using modified urushiol derived from Toxicodendron vernicifluum is provided. More particularly, the reactivity of a hydroxyl group of urushiol extracted from fresh Toxicodendron vernicifluum is removed before the lacquer is used as a UV coating agent for a substrate such as a steel sheet. Therefore, the substrate may have high antibacterial activity, and excellent appearance and functionalities such as far-infrared radiation, blocking of electromagnetic waves, enhanced corrosion resistance, high crosslinking speed when a low content of a photoinitiator is used, excellent surface gloss and high scratch resistance.
    Type: Application
    Filed: December 28, 2010
    Publication date: November 15, 2012
    Applicant: POSCO
    Inventors: Hye Jin Yoo, In Woo Cheong, Chang Se Byeon, Jae Ryung Lee, Jin Tae Kim, Jung Hwan Lee, Yang Ho Choi