Carbon Bonded To -ncx Or -xcn (e.g., Cyanate, Thiocyanate Or Isothiocyanate, Etc.) (x Is Chalcogen) Patents (Class 514/514)
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Patent number: 6380236Abstract: A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal composition in one or separate compositions, concurrently or non-concurrently. Also described is a kit which contains the unit dosage forms, a protective gel and appropriate dressings for ready application.Type: GrantFiled: June 29, 2001Date of Patent: April 30, 2002Assignee: Bradley Pharmaceuticals, Inc.Inventor: Daniel Glassman
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Publication number: 20020022655Abstract: Disclosed is a method for growth inhibition of human leukemic cells or therapeutic treatment method of a leukemic patient by using a medicament of which the effective ingredient is a methylsulfinylalkyl isothiocyanate such as 4-(methylsulfinyl)butyl isothiocyanate and 6-(methylsulfinyl)hexyl isothiocyanate, which can be prepared by extraction from the tissues of certain plants and can induce apoptosis in human leukemic cells. This medicament compound is little growth-inhibitive against normal cells as compared with leukemic cells, so that a remarkable therapeutic effect can be expected.Type: ApplicationFiled: December 12, 2000Publication date: February 21, 2002Inventors: Osamu Nakamura, Yoko Fuke, Hideki Ohba, Seiji Yasuda
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Publication number: 20020006957Abstract: This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, &bgr;-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.Type: ApplicationFiled: March 5, 2001Publication date: January 17, 2002Inventors: Adnan M.M. Mjalli, Ramesh Gopalaswamy, Kwasi S. Avor, Christopher L. Wysong, Andrew Patron
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Patent number: 6239124Abstract: A synergistic combination of an IL-2 transcription inhibitor (e.g., cyclosporin A or FK506) and 40-O-(2-hydroxyethyl)-rapamycin is provided, which is useful in the treatment and prevention of transplant rejection and also certain autoimmune and inflammatory diseases, together with novel pharmaceutical compositions comprising an IL-2 transcription inhibitor in combination with a rapamycin, e.g., 40-O-(2-hydroxyethyl)-rapamycin.Type: GrantFiled: January 28, 1999Date of Patent: May 29, 2001Assignee: Novartis AGInventors: Gerhard Zenke, Hendrik Schuurman, Barbara Haeberlin, Armin Meinzer
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Patent number: 6210881Abstract: The present invention relates to a method for reducing the amount of substances inhibitory to nucleic acid hybridization in samples. The method is practiced prior to release of target nucleic acid from cells of interest and involves contacting the sample with an agent which solubilizes the inhibitory substances and does not effectuate release of nucleic acids from cells in the sample, and then the cells from the agent.Type: GrantFiled: January 21, 1998Date of Patent: April 3, 2001Assignee: Becton, Dickinson and CompanyInventors: Michael C. Little, Oscar J. Llorin, Matthew P. Collis
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Patent number: 6207703Abstract: The invention involves methods and materials for treating and preventing non-invasive fungus-induced mucositis. Specifically, the invention involves administrating an antifungal agent such that it contact mucus in an amount, at a frequency, and for a duration effective to prevent, reduce, or eliminate non-invasive fungus-induced rhinosinusitis. This invention also provides methods and materials for diagnosing non-invasive fungus-induced rhinosinusitis and culturing non-invasive fungus from a mammalian mucus sample as well as specific antifungal formulations and medical devices for treating and preventing non-invasive fungus-induced rhinosinusitis. In addition, the invention provides methods and materials for treating and preventing other non-invasive fungus-induced mucositis conditions such as chronic otitis media, chronic colitis, and Crohn's disease. Further, the invention involves methods and materials for treating and preventing chronic asthma symptoms.Type: GrantFiled: October 22, 1998Date of Patent: March 27, 2001Inventor: Jens Ponikau
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Patent number: 6207705Abstract: The present invention provides novel biopesticides which can replace commercial pesticides and biopesticides which have been banned, restricted, or are being phased out, including, but not limited to chloropicrin, dichlorvos and methyl bromide. Many of the biopesticides of the present invention are excellent fumigants, possessing quick action and volatility, while posing less risk than currently used pesticides to humans and the environment. The biopesticides of the present invention are natural and closely-related synthetic derivatives or analogs related to two classes of natural compounds, namely glucosinolates and monoterpenoids.Type: GrantFiled: March 21, 1997Date of Patent: March 27, 2001Assignee: Iowa State University Research Foundation, Inc.Inventors: Joel R. Coats, Christopher J. Peterson, Rong Tsao, Aimee L. Eggler, Gregory L. Tylka
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Patent number: 6194453Abstract: Disclosed herein are compounds of the formula I wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy or alkoxy of 1-6 carbon atoms; and Y is cyano, —C(NR1 R2)═C(CN)2; wherein X═O or S, and R1 and R2 are independently H, benzyl, —CH(CH3)C6H6, —(CH2)nC6H6, phenyl; —CO2R; n=2-4; R is lower alkyl of 1-6 carbon atoms which are useful for treating inflammation and immunological diseases.Type: GrantFiled: December 21, 1998Date of Patent: February 27, 2001Assignee: Calyx Therapeutics, Inc.Inventors: Subramaniam Sriram, John Bright, Bishwajit Nag, Somesh D. Sharma
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Patent number: 6172117Abstract: Biocidal preservatives for use especially in preventing rotting and deterioration of wood include quaternary ammonium compounds which preferably have a fatty aliphatic substituent on the quaternary nitrogen atom. Especially preferred are cocoalkyl substituents. Other substituents can include alkoxy groups, arenes, and heterocyclic groups with or without ring substitutions, for example. The quaternary ammonium compound can also contain an amine nitrogen and can be complexed with copper.Type: GrantFiled: February 27, 1998Date of Patent: January 9, 2001Assignee: Akzo Nobel N.V.Inventors: John P. Bell, Andress K. Doyle, Robert F. Farmer, James F. Gadberyy, Douglas Lucas, Stanley B. Mirviss, William Parr
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Patent number: 6140362Abstract: A method for inhibiting mammalian cell growth is disclosed. The method uses compounds known as N-acetonylarylamides. The compounds have been shown to inhibit cell mitosis and to inhibit microtubule assembly. The method may be used to treat diseases associated with rapid cell growth, particularly cancer. The compounds used in the method of the present invention may be used in combination with other therapies and may be administered by known techniques for drug administration.Type: GrantFiled: September 29, 1997Date of Patent: October 31, 2000Assignee: Rohm and Haas CompanyInventors: Enrique Luis Michelotti, David Hamilton Young
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Patent number: 6124352Abstract: A method of treating fungal diseases as well as pharmaceutical, veterinary and agricultural compositions useful in such treatment. The method includes administering an effective antifungal amount of a compound of the formula (I): ##STR1## wherein S is a spacer selected from a nitrogen, an oxygen, an alkyl, an alkenyl, an alcohol, an ester, a polyester, an amino acid, a carbohydrate, or a nitrogen-containing positively charged group;L is a ligand selected from a hydrogen, a hydroxyl residue, an alkyl residue, an alkenyl residue, a benzyl residue, an alcohol residue, an ester residue, a polyester residue, an alkyl acid residue, a carbohydrate, a steroid, a lipid, an organic polymer, a nitrogen-containing positively charged group or a vitamin;R.sub.1 and R.sub.3 are halogen or hydroxyl; andR.sub.2 is hydrogen or alkyl.Type: GrantFiled: July 27, 1994Date of Patent: September 26, 2000Assignee: Jemlan, LLCInventor: Vladimir Z. Gurevich
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Patent number: 6114323Abstract: The present invention relates to methods for inhibiting protein aging. Accordingly, methods are disclosed for treating an animal to inhibit the formation of advanced glycosylation end products of target proteins with the animal by adminstering a pharmaceutical composition comprising an agent capable of reacting with the carbonyl moiety of the early glycosylation product, whereby the subsequent cross-linking of the early glycosylation product is inhibited. Agents of the present invention comprise aminoguanidine, its pharmaceutically acceptable salts, and mixtures thereof.Type: GrantFiled: December 17, 1998Date of Patent: September 5, 2000Assignee: The Rockefeller UniversityInventors: Anthony Cerami, Peter C. Ulrich, Michael A. Brownlee
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Patent number: 6107316Abstract: A method for treating protozoal infections is described. The method employs N-acetonylbenzamide compounds provided in an effective amount to inhibit the growth of protozoans. The compounds are useful in controlling such protozoan parasites as Giardia lamblia, Leishmania major, Entamoeba histolytica, Cryptosporidium parvum, Toxoplasma gondii and microsporidia.Type: GrantFiled: April 29, 1998Date of Patent: August 22, 2000Assignee: Rohm and Haas CompanyInventors: David Hamilton Young, Enrique Luis Michelotti, Thomas David Edlind, Santosh Kumar Katiyar
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Patent number: 6077866Abstract: Novel benzophenonehydrazone derivatives represented by the formula (I): ##STR1## wherein, R.sup.1 is halogen; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is cyano, optically substituted C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-4 alkynyl, C.sub.1-4 alkyl-carbonyl or C.sub.1-4 alkoxy-thiocarbonyl; R.sup.4 is hydrogen, phenyl, optionally substituted C.sub.1-6 alkyl, optionally substituted C.sub.2-8 alkenyl, --CO--R.sup.8, --CO--O--R.sup.9 or ##STR2## R.sup.5 is hydrogen, formyl, phenyl, optionally substituted C.sub.1-8 alkyl, optionally substituted C.sub.2-8 alkenyl, optionally substituted C.sub.3-8 alkynyl, optionally substituted C.sub.1-8 alkyl-arbonyl, optionally substituted C.sub.1-6 alkyl-oxalyl, optionally substituted C.sub.1-8 alkoxy-carbonyl, optionally substituted C.sub.1-8 alkoxy-oxalyl, optionally substituted C.sub.3-8 cycloalkyl-carbonyl, optionally substituted C.sub.2-8 alkenyl-carbonyl or optionally substituted benzoyl; R.sup.6 is hydrogen or halogen; R.sup.7 is hydrogen, halogen or C.sub.Type: GrantFiled: May 10, 1996Date of Patent: June 20, 2000Assignee: Nihon Bayer Agrochem K.K.Inventors: Yoshinori Kitagawa, Katsuaki Wada, Yoshiko Kyo, Yuichi Otsu, Yumi Hattori, Toru Obinata, Takahisa Abe, Katsuhiko Shibuya, Wolfram Andersch
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Patent number: 6069156Abstract: Compounds of the formula (I): ##STR1## and their pharmaceutically acceptable compositions are useful in inhibiting the activity of cyclic guanosine 3',5'-monophosphate phosphodiesterase.Type: GrantFiled: December 10, 1997Date of Patent: May 30, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Teruo Oku, Kozo Sawada, Akio Kuroda, Kazuhiko Ohne, Atsushi Nomoto, Naomi Hosogai, Yoshimitsu Nakajima, Akira Nagashima, Keizo Sogabe, Kouichi Tamura, Masakazu Kobayashi
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Patent number: 6022881Abstract: The presence of isobornyl thiocyanoethyl ether exerts a synergistic effect on the insecticidal activity against harmful wood eating insects of certain known insecticides selected from the group consisting of imidacloprid, phenyl pyrazole insecticides, pyrethroid insecticides and non-ester pyrethroid insecticides.Type: GrantFiled: March 30, 1999Date of Patent: February 8, 2000Assignee: Sankyo Company, LimitedInventors: Takehito Asai, Kenya Okumura, Toshiyasu Shizawa
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Patent number: 6020371Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses.Type: GrantFiled: December 16, 1997Date of Patent: February 1, 2000Assignee: Agouron Pharmaceuticals, Inc.Inventors: Peter S. Dragovich, Thomas J. Prins, Ru Zhou
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Patent number: 6013836Abstract: This invention relates to N'-substituted-N,N'-disubstitutedhydrazines of formula I ##STR1## wherein X and X' are independently O, S, or NR; A' and B' are independently substituted or unsubstituted aryl or aromatic heterocycle; wherein F is alkyl, alkenyl, or aralkyl; and wherein E is a tertiary carbon containing organic radical having a total of at least four carbon and halogen atoms but not more than six halogen atoms, or a non-tertiary carbon containing non-haloalkyl organic or organometallic radical having at least five atoms other than hydrogen, oxygen and halogen which are useful as insecticides, compositions containing those compounds, methods of producing the compounds, and methods of their use. More particularly, the invention relates to insect growth regulating compounds and compositions, and methods of using such compounds and compositions. Compounds of the present invention are particularly suitable for controlling plant-destructive insects in crops of cultivated plants, ornamentals and forestry.Type: GrantFiled: May 22, 1995Date of Patent: January 11, 2000Assignee: Rohm and Haas CompanyInventors: Adam Chi-Tung Hsu, Harold Ernest Aller, Dat Phat Le, Donald Wesley Hamp, Barry Weinstein, Raymond August Murphy
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Patent number: 6004569Abstract: A pesticide and a method of using the pesticide to kill invertebrates, especially insects, arachnids and larvae. The method is to prepare a mixture of a carrier with the pesticide and apply the mixture to the insects, arachnids and larvae and their habitat. The pesticide is a neurotransmitter affector utilizing octopamine receptor sites in the insects, arachnids and larvae. The affector agent is a chemical having a six membered carbon ring having substituted thereon at least one oxygenated functional group. The affector agent is a chemical component of a plant essential oil and is naturally occurring. Deposition of the chemicals of the present invention on a surface provides residual toxicity for up to 30 days. Various carriers for the affector agent are disclosed. The chemicals of the present invention deter feeding of insects, arachnids and larvae and also retard growth of the larvae of the insects and arachnids.Type: GrantFiled: June 6, 1997Date of Patent: December 21, 1999Assignee: Ecosmart Technologies, Inc.Inventors: Steven M. Bessette, Myron A. Beigler
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Patent number: 5985303Abstract: The invention provides a shelf-life extender for upholding the freshness of food, such as meat, vegetables, fruits, etc., in retail packages or in a refrigerator for an extended period of time. An isothiocyanic acid compound is supported on a matrix such as a natural mucilaginous polysaccharide or a solid organic acid and the supported compound is packaged in synthetic resin film or nonwoven fabric. The invention further provides an aqueous gel composition comprising a specified surfactant, an isothiocyanic acid compound, and a gelling agent and a hydrophobic gel composition comprising a specified hydrophobic dispersion medium, an isothiocyanic acid compound, and a gelling agent.Type: GrantFiled: August 2, 1996Date of Patent: November 16, 1999Inventors: Toru Okada, Kenji Kuranari
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Patent number: 5977123Abstract: The invention relates to novel oximether and acrylic acid derivatives of the formula (I) ##STR1## in which Z, G, Ar, E, R.sup.1 and R.sup.2 have the meanings as given in the specification, to processes for their preparation and to their use as fungicides.Type: GrantFiled: January 9, 1998Date of Patent: November 2, 1999Assignee: Bayer AktiengesellscgaftInventors: Peter Gerdes, Herbert Gayer, Ulrich Heinemann, Ralf Tiemann, Klaus Stenzel, Stefan Dutzmann
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Patent number: 5968505Abstract: Vegetable sources of cancer chemoprotective agents have been identified which are extraordinarily rich in glucosinolates, metabolic precursors of isothiocyanates. The vegetable sources are used to provide a dietary means of reducing the level of carcinogens in mammals.Type: GrantFiled: December 24, 1997Date of Patent: October 19, 1999Assignee: Johns Hopkins School of MedicineInventors: Jed W. Fahey, Paul Talalay
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Patent number: 5968498Abstract: The freshness of meat, vegetables and fruits in a refrigerator or food storage box can be retained for a long period of time by using (1) a freshness retaining gel composition which comprises a freshness retainer component comprising an isothiocyanic acid compound and an aliphatic carboxylic acid or (2) a freshness retaining gel composition which comprises a freshness retainer component comprising an isothiocyanic acid compound, a nonionic surfactant or a fatty acid ester, and a gelling agent.Type: GrantFiled: January 28, 1998Date of Patent: October 19, 1999Inventors: Toru Okada, Kenji Kuranari, Yukari Mihara
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Patent number: 5935943Abstract: The presence of isobornyl thiocyanoethyl ether exerts a synergistic effect on the insecticidal activity against harmful wood eating insects of certain known insecticides selected from the group consisting of imidacloprid, phenyl pyrazole insecticides, pyrethroid insecticides and non-ester pyrethroid insecticides.Type: GrantFiled: September 9, 1997Date of Patent: August 10, 1999Assignee: Sankyo Company, LimitedInventors: Takehito Asai, Kenya Okumura, Toshiyasu Shizawa
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Patent number: 5932614Abstract: Sulfonic acid stilbenes block the infection of cells by HIV and these compounds can be used to prevent viral infection.Type: GrantFiled: November 5, 1996Date of Patent: August 3, 1999Assignee: Merrell Pharmaceuticals Inc.Inventors: Alan D. Cardin, A. Stanley Tyms
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Patent number: 5916910Abstract: In accordance with the present invention, there are provided conjugates of nitric oxide scavengers (e.g., dithiocarbamates, or "DC") and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein. In addition, invention conjugates are more effective than unmodified pharmacologically active agents because cells and tissues contacted by the pharmacologically active agent(s) are protected from the potentially damaging effects of nitric oxide overproduction induced thereby as a result of the co-production of nitric oxide scavenger (e.g., dithiocarbamate), in addition to free pharmacologically active agent, when invention conjugate is cleaved.Type: GrantFiled: June 4, 1997Date of Patent: June 29, 1999Assignee: Medinox, Inc.Inventor: Ching-San Lai
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Patent number: 5880150Abstract: An antimicrobial agent comprising allyl isothiocyanate (AIT) packaged in a packaging material having a structure wherein part of the pores of a porous packaging substrate is filled with, or said pores are partially or entirely narrowed by a resin impervious to AIT vapor, and a method for controlling the AIT vapor release speed comprising enclosing AIT in the above-mentioned packaging material. According to the present invention, the AIT vapor release speed can be controlled, whereby enabling sustained release of AIT vapor and persistent effect of antimicrobial action. In addition, the antimicrobial agent of the present invention can be widely applied to food industries and various other fields where breeding and reproduction of deleterious microorganisms pose problems, since it is economical, compact and easy to use.Type: GrantFiled: July 10, 1995Date of Patent: March 9, 1999Assignees: The Green Cross Corporation, Rengo Co., Ltd.Inventors: Masao Fujita, Kiyoshi Kamei, Kiyoko Kawazu, Yuichi Mizukami, Yasushi Sekiyama
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Patent number: 5874466Abstract: Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.Type: GrantFiled: June 10, 1997Date of Patent: February 23, 1999Assignee: Rohm and Haas CompanyInventors: Enrique Luis Michelotti, Heather Lynnette Rayle, Randall Wayne Stephens, William Joseph Zabrodski
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Patent number: 5869067Abstract: The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.Type: GrantFiled: September 26, 1994Date of Patent: February 9, 1999Assignee: Centre International De Recherches Dermatologiques Galderma (CIRD Galderma)Inventors: Jean-Phillippe Rocher, Jean-Michel Bernardon
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Patent number: 5859214Abstract: Compounds of general formula I ##STR1## wherein Z.sup.1, Z.sup.2, X, R.sup.2 and R.sup.3 are as herein defined, are valuable pharmaceutical agents. In particular, the compounds are useful as contrast agents in NMR diagnosis.Type: GrantFiled: April 15, 1994Date of Patent: January 12, 1999Assignee: Schering AktiengesellshaftInventors: Heinz Gries, Erich Klieger, Bernd Raduchel, Heribert Schmitt-Willich, Hanns-Joachim Weinmann, Hubert Vogler, Gabriele Schuhmann-Giampieri, Jurgen Conrad
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Patent number: 5858402Abstract: In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in vivo to a suitable scavenger. The resulting complex renders the cyanide harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods.Type: GrantFiled: February 11, 1997Date of Patent: January 12, 1999Assignee: Medinox, Inc.Inventor: Ching-San Lai
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Patent number: 5854285Abstract: A compound of the formula I ##STR1## wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms;B is hydroxy or alkoxy of 1-6 carbon atoms; andY is cyano, ##STR2##--C(NR.sub.1 R.sub.2).dbd.C(CN).sub.2 ;wherein X=O or S, and R.sub.1 and R.sub.2 are independently H, benzyl, --CH(CH.sub.3), C.sub.6 H.sub.5--(CH.sub.2).sub.n C.sub.6 H.sub.6, phenyl; --CO.sub.2 R;n=2-4; R is lower alkyl of 1-6 carbon atomsis used for treating inflammation and immunological diseases.Type: GrantFiled: April 3, 1997Date of Patent: December 29, 1998Assignee: Natpro, Inc.Inventors: Subramaniam Sriram, John Bright, Bishwajit Nag, Somesh D. Sharma
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Patent number: 5763185Abstract: The present invention relates to a method for reducing the amount of substances inhibitory to nucleic acid hybridization in samples. The method is practiced prior to release of target nucleic acid from cells of interest and involves contacting the sample with an agent which solubilizes the inhibitory substances and does not effectuate release of nucleic acids from cells in the sample, and then the cells from the agent.Type: GrantFiled: December 30, 1996Date of Patent: June 9, 1998Assignee: Becton Dickinson and CompanyInventors: Matthew P. Collis, Michael C. Little, Oscar J. Llorin
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Patent number: 5756542Abstract: A method of protecting a tree including removing parts of the tree which are one of susceptible to necrosis from pathogenic microbes or affected by necrosis and leaving exposed tree surfaces; and applying to the exposed tree surfaces a composition which is an ointment and which is effective to protect a tree against disease which includes allyl isothiocyanate; vinyl acetate resin as a spreading agent; water-based colored paint; metallic powder which is finely divided and which is one of iron or ferrous oxide; and pH regulating agent. The allyl isothiocyanate may be encapsulated by a coating material.Type: GrantFiled: June 23, 1995Date of Patent: May 26, 1998Assignee: Takeshi KojimaInventors: Takeshi Kojima, Akinori Kimura
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Patent number: 5753239Abstract: Bi-aromatic compounds are provided along with methods for their preparation and use.Type: GrantFiled: June 6, 1995Date of Patent: May 19, 1998Assignee: Centre International de Recherches Dematologiques Galderma (Cird Galderma)Inventors: Jean-Philippe Rocher, Jean-Michel Bernardon
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Patent number: 5728730Abstract: Compositions for controlling the growth of microorganisms in or on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: March 3, 1997Date of Patent: March 17, 1998Assignee: Buckman Laboratories International, Inc.Inventors: David Oppong, Vanja M. King
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Patent number: 5717109Abstract: The present invention provides compounds of formula ##STR1## in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists of one or more of the actions of L-glutamate at metabotropic excitatory amino acid receptors.Type: GrantFiled: July 10, 1995Date of Patent: February 10, 1998Assignee: Eli Lilly and CompanyInventors: M. Brian Arnold, Thomas J. Bleisch, David R. Helton, Mary Jeanne Kallman, Paul L. Ornstein, Darryle D. Schoepp, Joseph P. Tizzano
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Patent number: 5703124Abstract: An antimicrobial composition comprising AIT and a polyhydric alcohol which may have aldehyde group or ketone group; an antimicrobial composition comprising a surfactant and said composition; a method for treating microorganisms; and a method for retaining freshness of vegetables, etc., both of which methods comprising treating the target substances such as perishables with the composition of the present invention or an aqueous solution containing said composition.Type: GrantFiled: March 14, 1995Date of Patent: December 30, 1997Assignee: The Green Cross CorporationInventors: Asami Takata, Shoko Numata, Yuichi Mizukami, Yasushi Sekiyama, Masato Takahashi
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Patent number: 5688819Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.Type: GrantFiled: February 22, 1996Date of Patent: November 18, 1997Assignee: AllerganInventors: David F. Woodward, Steven W. Andrews, Robert M. Burk, Michael E. Garst
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Patent number: 5677333Abstract: A method for controlling phytopathogenic fungi comprises applying a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of manganese-zinc ethylenebis(dithiocarbamate), manganese ethylenebis(dithiocarbamate), zinc ammoniate ethylenebis(dithiocarbamate), zinc ethylenebis(dithiocarbamate), 2-cyano-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamide, and (E,Z) 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl)morpholine to plant seed, to plant foliage or to a plant growth medium and provides higher fungicidal activity than separate use of the same compounds.Type: GrantFiled: July 8, 1996Date of Patent: October 14, 1997Assignee: Rohm and Haas CompanyInventors: Daniel Louis Loughner, Enrique Luis Michelotti, Willie Joe Wilson, David Hamilton Young
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Patent number: 5672625Abstract: Sulfonic acid stilbenes block the infection of cells by HSV and CMV and these compounds can be used to treat viral infection.Type: GrantFiled: June 5, 1995Date of Patent: September 30, 1997Assignee: Merrell Pharmaceuticals Inc.Inventors: Alan D. Cardin, A. Stanley Tyms
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Patent number: 5665772Abstract: Novel derivatives of rapamycin, particularly 9-deoxorapamycins, 26-dihydro-rapamycins, and 40-0-substituted and 28,40-0,0-di-substituted rapamycins, are found to have pharmaceutical utility, particularly as an immunosuppressants.Type: GrantFiled: April 7, 1995Date of Patent: September 9, 1997Assignee: Sandoz Ltd.Inventors: Sylvain Cottens, Richard Sedrani
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Patent number: 5633278Abstract: Compositions for controlling the growth of microorganisms in or on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: June 21, 1996Date of Patent: May 27, 1997Assignee: Buckman Laboratories International, Inc.Inventors: David Oppong, Vanja M. King
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Patent number: 5629346Abstract: Certain N-acetonylbenzamides exhibit low toxicity to plants are particularly useful for control of fungi, especially Phycomycetes.Type: GrantFiled: June 6, 1995Date of Patent: May 13, 1997Assignee: Rohm and Haas CompanyInventors: H. Edwin Carley, Ashok K. Sharma, Colin Swithenbank
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Patent number: 5607978Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, either or thioether groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) derivatives of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.Type: GrantFiled: January 11, 1995Date of Patent: March 4, 1997Assignee: AllerganInventors: David F. Woodward, Steven W. Andrews, Robert M. Burk, Michael E. Garst
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Patent number: 5589169Abstract: A method and pharmaceutical composition for the prevention of fibrin deposition or adhesion formation by topical application of a composition to a site of potential fibrin deposition or adhesion formation comprising a sparingly soluble enzyme that is continuously released at that site for a period of time of from about three days to two weeks which may include an inert adherence enhancing vehicle.Type: GrantFiled: April 13, 1990Date of Patent: December 31, 1996Assignee: Genentech, Inc.Inventors: Marjorie A. Mohler, Tue H. Nguyen
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Patent number: 5530024Abstract: Compositions for controlling the growth of microorganisms in or on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: June 6, 1995Date of Patent: June 25, 1996Assignee: Buckman Laboratories International, Inc.Inventors: David Oppong, Vanja M. King
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Patent number: 5494932Abstract: Sulfonic acid stilbenes block the infection of cells by HSV, and CMV and these compounds can be used to treat viral infection.Type: GrantFiled: May 25, 1994Date of Patent: February 27, 1996Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Alan D. Cardin, A. Stanley Tyms
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Patent number: 5441979Abstract: Compositions for controlling the growth of microorganisms in on a product, material or medium comprising synergistically effective amounts of methylene-bis(thiocyanate) and at least one organic acid, its salt or ester are disclosed. Methods to control growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.Type: GrantFiled: January 27, 1994Date of Patent: August 15, 1995Assignee: Buckman Laboratories International, Inc.Inventors: David Oppong, Vanja M. King
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Patent number: RE36784Abstract: Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II enzymes selectively without the induction of aryl hydrocarbon receptor-dependent cytochromes P-450 (phase I enzymes). Analogues differing in the oxidation state of sulfur and the number of methylene groups were synthesized, and their inducer potencies were measured. Sulforaphane is the most potent of these analogues. Other analogues having different substituent groups in place of the methylsulfinyl group of sulforaphane were also synthesized and assessed. Of these, the most potent are 6-isothiocyanato-2-hexanone and exo-2-acetyl-6-isothiocyanatonorbornane.Type: GrantFiled: May 2, 1997Date of Patent: July 18, 2000Assignee: The Johns Hopkins UniversityInventors: Cheon-Gyu Cho, Gary H. Posner, Paul Talalay, Yuesheng Zhang