Carbon To Carbon Unsaturation In R Patents (Class 514/627)
  • Publication number: 20140193349
    Abstract: The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, prefe
    Type: Application
    Filed: August 3, 2012
    Publication date: July 10, 2014
    Applicant: L'OREAL
    Inventors: Michela Zuccolo, Roland Jourdain, Lionel Breton, Mauro Maccarrone
  • Publication number: 20140187619
    Abstract: Methods of treatment in subjects suffering from diabetes mellitus or obesity are provided. The methods comprise the step of administering an active agent directly to the small intestine in the subject. In particular, the active agent may be administered directly to the duodenum in the subject. The active agents useful in the treatments described herein include analgesic agents and, in particular, antinociceptive agents such as capsaicin, resiniferatoxin, and their analogues.
    Type: Application
    Filed: July 18, 2012
    Publication date: July 3, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Pankaj Jay Pasricha, Liansheng Liu
  • Publication number: 20140171511
    Abstract: The present invention relates to a product comprising capsaicin or a capsaicinoid for use in the treatment of cough, in particular chronic persistent unexplained cough or increased cough reflex sensitivity. More precisely, the invention concerns oral formulations for reducing and relieving coughing from other irritants than capsaicin itself. The capsaicin formulations are stated to down-regulate coughing following a regular consumption. Said products can also be used in the treatment of rhinitis and other conditions known to have cough symptoms.
    Type: Application
    Filed: July 4, 2012
    Publication date: June 19, 2014
    Inventor: Eva Millqvist
  • Publication number: 20140161868
    Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 12, 2014
    Applicant: GENSCO LABORATORIES LLC
    Inventors: Carlos A. Alfaras, Paul M. Zimmerman, Urbano Zamora
  • Publication number: 20140163112
    Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Application
    Filed: February 18, 2014
    Publication date: June 12, 2014
    Applicant: Pacific Tech Industries, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20140161763
    Abstract: The methods, kits, and products for controlling a target insect population are disclosed in which a non-host plant containing a toxin and a chemical attractant known to attract the target insect is treated with chemical attractant from a plant of interest. The chemical attractant induces the target insect to lay eggs on the non-host plant. The resulting offspring die of starvation from refusing to feed on the non-host plant. The non-host plant and plant of interest contain at least one common chemical. The methods, kits, and products for controlling a target insect population using an extract from a non-host plant are also disclosed. The non-host plant extract is applied to the plant of interest, and when ingested or applied directly to the target insect, kills the target insect or causes it to develop with deformities.
    Type: Application
    Filed: January 28, 2011
    Publication date: June 12, 2014
    Applicant: University of the West Indies, a Regional Institution, established by Royal Charter
    Inventors: Trevor Herbert Yee, Charah Tabetha Watson, Eric Garraway, Dwight Robinson, Nemoi Nastassia Sri Garcia Chisholm
  • Publication number: 20140155426
    Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering.
    Type: Application
    Filed: January 7, 2014
    Publication date: June 5, 2014
    Applicant: Purdue Pharma L.P.
    Inventor: Richard Sackler
  • Patent number: 8741958
    Abstract: The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: June 3, 2014
    Assignee: Takasago International Corporation
    Inventors: Louis Lombardo, Michael E. Lankin, Kenya Ishida, Shigeru Tanaka, Hideo Ujihara, Kenji Yagi, Jennifer B. Mei, Carter B. Green, Amrit S. Mankoo
  • Publication number: 20140147481
    Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 29, 2014
    Applicants: UNIVERSITY OF RHODE ISLAND RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Gerwick, Lena Gerwick, Huykjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
  • Patent number: 8735427
    Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: May 27, 2014
    Assignee: Pacific Tech Industries, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20140142073
    Abstract: Capsaicinoid formulations and methods of treatment are disclosed herein which can be utilized to treat/attenuate pain in mammals. Typically, administration is via injection at a discrete site to provide pain relief for an extended period of time. The formulations are administered in a pharmaceutically acceptable vehicle. The formulations include an analgesic agent in an amount sufficient to attenuate the burning and hyperalgesic effects of capsaicinoid administration. The invention also includes a method of treating pain by administering a corticosteroid followed by administration of a capsaicinoid.
    Type: Application
    Filed: November 12, 2013
    Publication date: May 22, 2014
    Applicant: API Genesis, LLC
    Inventors: Charles A. Birbara, Philip J. Birbara, Daniel Bucks, Mary Coughlin
  • Publication number: 20140134135
    Abstract: The invention provides compositions and methods for preserving lean body mass during weight loss in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day.
    Type: Application
    Filed: May 8, 2012
    Publication date: May 15, 2014
    Applicant: NESTEC SA
    Inventors: Delphine Tissot-Favre, Yuanlong Pan
  • Publication number: 20140128335
    Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.
    Type: Application
    Filed: February 23, 2012
    Publication date: May 8, 2014
    Applicants: UNIVERSITE D'AIX-MARSEILLE, UNIVERSITE DE CORSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Michel Bolla, Jean Michel Brunel, Joseph Pierre Felix Casanova, Vannina Lorenzi, Liliane Berti
  • Patent number: 8703824
    Abstract: The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikimic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: April 22, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ramishetti Srinivas, Arup Garu, Sachin B. Agawane, Arabinda Chaudhuri
  • Patent number: 8697752
    Abstract: Grease-like compositions are provided for repelling insects and preventing undesirable behavior in hoofed animals. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: April 15, 2014
    Assignee: Pacific Tech Industries, Inc.
    Inventors: Richard Numata, Ryan Willey
  • Publication number: 20140094521
    Abstract: The objective of the present invention is to provide a new compound which is effective in treating blood cancer, particularly multiple myeloma, and which is also effective in suppressing an SP cell, i.e. Side Population Cell, which is a cause of recurrence of cancer. The compound according to the present invention is a novel compound which has the specific benzylamine structure.
    Type: Application
    Filed: May 23, 2012
    Publication date: April 3, 2014
    Applicant: THE UNIVERSITY OF TOKUSHIMA
    Inventors: Daisuke Tsuji, Kohji Itoh, Akira Otaka, Akira Shigenaga, Masahiro Abe, Masahiro Hiasa
  • Publication number: 20140088196
    Abstract: System, including methods compositions, and kits, for controlling the growth of fungi and other pathogens in plants using at least one alkamide, which may function by increasing or eliciting natural defense mechanisms of the plants against such pathogens.
    Type: Application
    Filed: September 16, 2013
    Publication date: March 27, 2014
    Applicant: Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional (CINVESTAV)
    Inventors: José López-Bucio, Jorge Molina-Torres, Luis Rafael Herrera-Estrella
  • Publication number: 20140086857
    Abstract: Compositions comprising siloxane polymers are disclosed. The compositions are useful as thixotropic bases for a variety of components, such as antimicrobial agents, sterilants, medicaments, antibiotics, analgesics, essential oils, preservatives, colorants, fragrances, and the like. Methods for preparing the compositions are also disclosed.
    Type: Application
    Filed: May 10, 2012
    Publication date: March 27, 2014
    Applicant: QUADSIL, INC.
    Inventor: John D. Blizzard
  • Patent number: 8680153
    Abstract: The present invention relates to methods for the treatment of a disease or condition associated with lipid imbalance, comprising (a) decreasing arachidonic acid (AA) levels, (b) increasing docosahexaenoic acid (DHA) levels, (c) increasing DHA/AA ratio or (d) any combination of (a)-(c) in a subject using fenretinide. The invention also relates to diagnostic and screening methods based on the determination of lipid levels.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: March 25, 2014
    Assignee: The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Danuta Radzioch, Claudine Guilbault, Juan Bautista De Sanctis
  • Publication number: 20140080914
    Abstract: There is provided an aqueous acrylamide solution including 2,2,6,6-tetramethylpiperidine 1-oxyl in the ratio of 2 to 100 mg and manganese ions in the ratio of 0.2 to 2.0 mg per 1 kg of acrylamide. According to the present invention, an aqueous acrylamide solution having favorable quality and high stability with suppressed polymerization of acrylamide, a stabilizer used therefore, and a stabilization method can be provided.
    Type: Application
    Filed: May 21, 2012
    Publication date: March 20, 2014
    Applicant: Mitsubuishi Rayon Co., Ltd.
    Inventors: Makoto Kanou, Norifumi Hagiya
  • Patent number: 8673982
    Abstract: This invention relates to certain ceramide-analogues of FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol; fingolimod). In particular, the present invention relates to pharmaceutical compositions comprising these compounds, as well as processes for their preparation and their use in the treatment of autoimmune conditions, such as multiple sclerosis.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: March 18, 2014
    Assignee: Novartis AG
    Inventors: Volker Brinkmann, Guido Jordine, Markus Zollinger, Claudia Sayer
  • Publication number: 20140073612
    Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.
    Type: Application
    Filed: September 11, 2012
    Publication date: March 13, 2014
    Inventors: Carlos A. Alfaras, Paul M. Zimmerman, Urbano Zamora
  • Publication number: 20140056990
    Abstract: Provided herein formulations of capsaicin for delivery by nasal route and methods of using the formulations for the treatment of migraines and other severe headaches. The formulations described herein contain mucoadhesives to optimize the therapeutic effect of capsaicin by intranasal delivery.
    Type: Application
    Filed: August 23, 2013
    Publication date: February 27, 2014
    Applicant: VR1, INC.
    Inventor: Anjan Chatterjee
  • Publication number: 20140051751
    Abstract: Environmentally-friendly alternatives to organometallic antifoulants that are efficacious at preventing biofouling by organisms such as the zebra mussel. Preferred antifoulant compositions utilize compounds having a Lipophilic-Amide-Spacer-ElectroNegative (“LASEN”) structural motif, such as capsaicin, and compounds having a TetraHydroCannibinoid (“THC”) structural motif. The antifoulant compositions are non-toxic, and effective.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicants: The Board of Regents of the University of Texas System, University of North Texas Health Science Center at Fort Worth
    Inventors: John A. Schetz, Robert F. McMahon
  • Patent number: 8642598
    Abstract: The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said compounds, and methods of treatment using at least one compound. In particular, compounds of the general formula (I) are useful for inhibiting glycogen synthase kinase 3 (GSK-3).
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: February 4, 2014
    Assignees: AbbVie Inc., AbbVie Deutschland GmbH & Co. KG
    Inventors: Sean C. Turner, Margaretha Henrica Maria Bakker, Kent D. Stewart
  • Publication number: 20140018328
    Abstract: The present invention relates to compositions including anhydrous compositions which include a dimethicone crosspolymer and/or dimethicone elastomer gum and one or more skin care products which may include retinoic acid, retinoic acid derivatives, retinal, retinol and/or retinyl esters, and methods of making, storing, and using such compositions.
    Type: Application
    Filed: August 7, 2013
    Publication date: January 16, 2014
    Applicant: Chemsil Silicones, Inc.
    Inventors: James Jefferies Harrison, Nohemi Harrison
  • Patent number: 8623914
    Abstract: The object of the invention is to find the actions of the crude drugs contained in Daikenchuto or their components and the synergistic effect of the components with one another or with other pharmacologically active substances, and to provide new drugs or pharmaceutical compositions based on the findings. The invention is directed to intestinal peristaltic motility-enhancers comprising an effective amount of hydroxy-?-sanshool or a plant containing the same or an extract thereof; compositions comprising a combination of hydroxy-?-sanshool or a plant containing the same or an extract thereof and capsaicin or a plant containing the same or an extract thereof or bethanechol or a salt thereof; as well as a method for improving intestinal motility which comprises administering the composition to a patient.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: January 7, 2014
    Assignee: TSUMURA & Co.
    Inventor: Nobuhiro Ohtake
  • Patent number: 8592484
    Abstract: Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: November 26, 2013
    Assignee: Cognis IP Management GmbH
    Inventors: Philippe Moussou, Olga Freis, Louis Danoux, Philippe Grisoni, Laurent Bailly
  • Publication number: 20130303620
    Abstract: The present invention provides compositions and methods for relieving pain at a site in a human or animal in need thereof by administering at a discrete site in a human or animal in need thereof a dose of capsaicin in an amount effective to denervate a discrete site without eliciting an effect outside the discrete location, the dose of capsaicin ranging from 1 ?g to 3000 ?g.
    Type: Application
    Filed: April 12, 2013
    Publication date: November 14, 2013
    Applicant: Vallinex, Inc.
    Inventor: Vallinex, Inc.
  • Publication number: 20130304002
    Abstract: A dermal drug delivery system is provided which comprises at least two components, for example, a sheet of a solid and flexible material, and a vehicle liquid comprising a solvent and optionally other ingredients. A drug, which can be unstable in said solvent but needs the solvent for being delivered into the skin, can be impregnated in the sheet. Other ingredients, such as agents for fastening the drug on the sheet can also be impregnated in the sheet. These two components may be stored separately and joined either shortly before or at the time of application. To use the system, the vehicle liquid may be applied either on the target skin area or on the sheet, and the sheet may then be applied on the target skin area so that the vehicle liquid is positioned between the sheet and the skin and brought into contact with the ingredients impregnated in the sheet.
    Type: Application
    Filed: November 8, 2011
    Publication date: November 14, 2013
    Inventor: Jie Zhang
  • Patent number: 8580282
    Abstract: The present invention relates to tetracaine based anesthetic formulations and methods of use thereof. The invention further relates to topical formulations of tetracaine and methods of topically anesthetizing body tissues. The present invention also relates to tetracaine based dental anesthetic formulations and methods for anesthetizing the maxillary dental arch using these formulations.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: November 12, 2013
    Assignee: St. Renatus, LLC
    Inventor: Mark David Kollar
  • Publication number: 20130295159
    Abstract: A system and method for optimizing the systemic delivery of growth-arresting lipid-derived bioactive drugs or gene therapy agents to an animal or human in need of such agents utilizing nanoscale assembly systems, such as liposomes, resorbable and non-aggregating nanoparticle dispersions, metal or semiconductor nanoparticles, or polymeric materials such as dendrimers or hydrogels, each of which exhibit improved lipid solubility, cell permeability, an increased circulation half life and pharmacokinetic profile with improved tumor or vascular targeting.
    Type: Application
    Filed: November 9, 2012
    Publication date: November 7, 2013
    Inventors: Mark Kester, Thomas Stover, Tao Lowe, James H. Adair, Young Shin Kim
  • Publication number: 20130281294
    Abstract: Methods and compositions for controlling plant pests, particularly weeds and/or plant phytopathogens using sarmentine and/or analogs thereof are disclosed.
    Type: Application
    Filed: June 17, 2013
    Publication date: October 24, 2013
    Inventors: HUAZHANG HUANG, Ratnakar Asolkar
  • Publication number: 20130267571
    Abstract: The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.
    Type: Application
    Filed: September 14, 2011
    Publication date: October 10, 2013
    Applicant: NeuroQuest Inc.
    Inventors: Mark A. Reed, Donald Weaver, Shengguo Sun, Alexander McLellan, Erhu Lu
  • Publication number: 20130266588
    Abstract: This invention relates generally to a therapeutic use of TLR3 and TLR7 inhibitors to treat or reduce pruritus in a subject.
    Type: Application
    Filed: October 21, 2011
    Publication date: October 10, 2013
    Applicant: BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Ru-Rong Ji, Temugin Berta, Zhen-Zhong Xu, Tong Liu, Chul-Kyu Park
  • Publication number: 20130252925
    Abstract: The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 26, 2013
    Applicant: API Genesis, LLC
    Inventors: Daniel Bucks, Philip J. Birbara
  • Publication number: 20130224318
    Abstract: The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.
    Type: Application
    Filed: February 26, 2013
    Publication date: August 29, 2013
    Applicant: Avon Products, Inc.
    Inventor: Avon Products, Inc.
  • Publication number: 20130217773
    Abstract: This invention is designed for the convenient and reliable delivery of predetermined doses of topical therapeutic medications applied to the skin. The importance of this method of application is that it allows reducing the amount of a therapeutic agent used in one session or reducing amount of sessions per day by eliminating the application of medications to a treating surface by hand. The emphasis is on making therapeutic agents available for self-administration, especially for partially disabled people with conditions such as arthritis and/or visual impairments who would not be able to use these medications without assistance.
    Type: Application
    Filed: February 22, 2012
    Publication date: August 22, 2013
    Inventor: Mikhail Levitin
  • Publication number: 20130210905
    Abstract: The present invention provides methods and kits for the selective ablation of pain-sensing neurons. The methods comprise administration of a vanilloid receptor agonist to a ganglion in an amount that causes death of vanilloid receptor-bearing neurons. Accordingly, the present invention provides methods of controlling pain and inflammatory disorders that involve activation of vanilloid receptor-bearing neurons.
    Type: Application
    Filed: December 17, 2012
    Publication date: August 15, 2013
    Applicant: The Gov. of the U.S.A as Represented by the Secretary of the Dept. of Health and Human Service
    Inventor: The Gov. of the U.S of America as Represented by the Secretary of the Dept. of Health and Human Services
  • Publication number: 20130209373
    Abstract: Nutritional compositions that mimic whole foods and methods of using the nutritional compositions are provided. The nutritional compositions may include an increased number and variety of fruits and vegetables, an increased variety of macronutrient sources and an increased amount of other components that are found in whole foods. The nutritional compositions may also include ethnicity-specific meals and organic ingredients and provide emotional appeal to the patient and/or the patient's caregiver.
    Type: Application
    Filed: June 28, 2011
    Publication date: August 15, 2013
    Applicant: NESTEC S.A.
    Inventors: Jennifer Mager, Zamzam Fariba Roughead, Heidi Storm, James Scott Teresi
  • Publication number: 20130210921
    Abstract: A method for giving warmth to skin, wherein an external composition for skin is provided, which gives good warmth without inducing irritation or pain and whose sustainability of warmth is good. The external composition for skin contains (A) an agent for giving warmth and (B) at least one member selected from the group consisting of fatty acid esters of aliphatic polyhydric alcohols and aromatic carboxylic acid esters of lower alcohols or aliphatic polyhydric alcohols.
    Type: Application
    Filed: February 14, 2013
    Publication date: August 15, 2013
    Applicant: ROHTO PHARMACEUTICAL CO., LTD.
    Inventor: ROHTO PHARMACEUTICAL CO., LTD.
  • Publication number: 20130197094
    Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of a TRPV1 compound (e.g., capsaicinoid compound) at or near a target site, one can relieve pain caused by diverse sources, including but not limited to, postoperative pain, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
    Type: Application
    Filed: February 1, 2012
    Publication date: August 1, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Nicholas A. Moore, Danielle L. Clay
  • Publication number: 20130172407
    Abstract: A pharmaceutical composition including oleoylethanolamide (OEA) is administered to inhibit tumor/cancer cell proliferation. The pharmaceutically composition may additionally include vitamin A, carotenoids, ?-3 polyunsaturated fatty acid, ?-6 polyunsaturated fatty acid and/or conjugated linolenic acid. The tumor/cancer may be colorectal cancer, lung adenocarcinoma, breast cancer, hepatoma, oral cancer and/or stomach adenocarcinoma.
    Type: Application
    Filed: November 6, 2012
    Publication date: July 4, 2013
    Applicant: China Medical University
    Inventor: China Medical University
  • Patent number: 8466192
    Abstract: Methods and compositions for controlling plant pests, particularly weeds and/or plant phytopathogens using sarmentine and/or analogs thereof are disclosed.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: June 18, 2013
    Assignee: Marrone Bio Innovations, Inc.
    Inventors: Huazhang Huang, Ratnakar Asolkar
  • Publication number: 20130142851
    Abstract: The present invention relates to medically efficacious agents coated with substance that forms a liquid impermeable but gas permeable layer, the treatment of medical conditions therewith, and particularly medical conditions at least partially characterised by blockage or other malfunction of ducts of exocrine glands and especially ducts of sweat glands.
    Type: Application
    Filed: January 25, 2013
    Publication date: June 6, 2013
    Inventor: Warren Ward
  • Patent number: 8445707
    Abstract: The disclosure herein provides the compounds of Formulas 1, 2 and 3 and their pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, and/or injection. Such compositions may be used for the treatment of metabolic conditions, cystinosis, non-alcoholic Steatohepatitis, hypertriglyceridemia, and/or neurodegenerative disorders, and/or their associated complications.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: May 21, 2013
    Assignee: Krisani Biosciences (P) Ltd.
    Inventor: Mahesh Kandula
  • Publication number: 20130102681
    Abstract: The present invention is directed to methods of modulating the activity of an isoform of manganese superoxide dismutase which is useful for the treatment of diseases such as heart failure.
    Type: Application
    Filed: December 3, 2012
    Publication date: April 25, 2013
    Applicant: Mito Tek, LLC
    Inventor: Mito Tek, LLC
  • Publication number: 20130102680
    Abstract: The present invention relates to a method of treating hyperalgesia in a subject, which involves administering to a subject an amount of a TRPV1 agonist compound that selectively inhibits hyperactive nociceptive neurons. The present invention also relates to a method of selectively inhibiting hyperactive nociceptive neurons. Also disclosed is a method for reducing the electrical activity of hypersensitive neurons sensitized to TRPV1. The present invention also relates to a method for identifying candidate compounds that selectively inhibit hyperactive nociceptive neurons. Also disclosed is a pharmaceutical composition.
    Type: Application
    Filed: October 9, 2012
    Publication date: April 25, 2013
    Applicant: CORNELL UNIVERSITY
    Inventor: CORNELL UNIVERSITY
  • Patent number: 8404277
    Abstract: A matrix-type transdermal drug delivery system including capsaicin or a capsaicin derivative as an active component and used for treating neuropathy, pain, and inflammation and a preparation method thereof are provided. The matrix-type transdermal drug delivery system includes: a drug protecting layer; a matrix layer formed on the drug protecting layer and including 0.1-25 wt % of capsaicin or a capsaicin derivative, 40-95 wt % of an adhesive including a water-insoluble acrylic polymer, 1-30 wt % of an alcohol having a molecular weight of 600 Daltons or less, 0.1-20 wt % of a nonionic surfactant, and 0.1-20 wt % of a solubilizing agent including a hydrophilic polymer; and a release liner formed on the matrix layer, and is used for treating neuropathy, pain, or inflammation.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: March 26, 2013
    Assignee: Samyang Biopharmaceuticals Corporation
    Inventors: Jin-Deok Song, Dong-Won Kim
  • Publication number: 20130059801
    Abstract: The invention relates to fatty acid amides; compositions comprising an effective amount of a fatty acid amide; and methods for treating or preventing cancer, a metabolic disease or a neurodegenerative disease comprising the administration of an effective amount of a fatty acid amide.
    Type: Application
    Filed: August 31, 2012
    Publication date: March 7, 2013
    Applicant: Catabasis Pharmaceuticals, Inc.
    Inventors: Jill C. Milne, Michael R. Jirousek, Jean E. Bemis, Chi B. Vu, Amal Ting