Plural Oxygens Patents (Class 514/718)
  • Publication number: 20120184513
    Abstract: The invention relates to organic compounds having the ability to reduce or suppress the onset of skin irritation induced by extraneous cause selected from the group of 2-heptylcyclopentanone, 2-ethoxynaphthalene; 2-methoxynaphthalene; 1-methoxy-4-(prop-1-enyl)benzene; 1-(cyclopropylmethyl)-4-methoxybenzene; wherein X, Y, and R1 to R11 have the same meaning as given in the description. Furthermore the invention refers to compositions for topical application to the skin comprising them. It further relates to a method of reducing or suppressing the formation of skin irritation.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 19, 2012
    Applicant: Givaudan SA
    Inventors: Andreas NATSCH, Michael WASESCHA
  • Publication number: 20120177725
    Abstract: The present invention relates to liposomal pharmaceutical preparations which include active agents such as antiseptic agents, wound-healing agents, or combinations thereof, useful in the treatment of external wounds. The active agents are encapsulated in liposomes, and the liposomes are incorporated in pharmaceutical preparations such as liquids, ointments, gels, lotions, or creams capable of delivering the active agents to external wound sites. The invention further relates to methods of preparation of the liposomes and the pharmaceutical preparations, and to methods of treatment of external wounds and ophthalmic infections.
    Type: Application
    Filed: March 9, 2012
    Publication date: July 12, 2012
    Inventors: Dieter Ruckert, Hermann Gumbel, Wolfgang Fleischer, Karen Reimer, Horst Winkler
  • Publication number: 20120148520
    Abstract: The present inventions relate to a number of fields including wound healing, a waterless antibacterial disinfectant, a surgical scrub, insect repellant, and methods of treating traumatic injuries, particularly those on the battlefield where there is a need to stabilize the patient and prevent infection.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 14, 2012
    Inventors: Michael Strobel, Gene Komer
  • Publication number: 20120101085
    Abstract: The present teachings provide compounds of Formulae I and II: and pharmaceutically acceptable salts, hydrates, complexes, esters, and prodrugs thereof, wherein R1, R1?, R2, R2?, R3, R3?, and X are as defined herein. The present teachings also provide methods of making the compounds of formulae I and II, and methods of treating RyR-associated conditions, disorders, and diseases that include administering a therapeutically effective amount of a compound of formula I or II to a subject in need thereof. In addition, the present teachings relate to methods of reducing the open probability of a ryanodine receptor, and methods of reducing Ca2+ release across a ryanodine receptor (e.g., into the cytoplasm of a cell), by contacting a compound of formula I or II with a ryanodine receptor.
    Type: Application
    Filed: April 15, 2010
    Publication date: April 26, 2012
    Applicant: State of Oregon By and Through the State Board of Higher Education on Behalf of Portland State Univ.
    Inventors: Jonathan J. Abramson, Robert Michael Stongin
  • Publication number: 20120087874
    Abstract: The present invention includes compositions for imparting a controlled-release warming sensation to the oral receptor areas of a user. The oral, controlled-release warming compositions include a warming agent and a hydrated or swollen food-grade polymer which forms a matrix with the warming agent. Also included are oral delivery systems for the warming compositions, methods for preparing same, and methods for imparting and sustaining a warming sensation in the mouth and upper portion of the gastrointestinal tract of the user.
    Type: Application
    Filed: December 9, 2011
    Publication date: April 12, 2012
    Inventors: Jamileh Lakkis, Susan Pettigrew
  • Publication number: 20120087961
    Abstract: The invention relates to agents which combat the hepatitus A virus, containing only minimal amounts of chlorine-containing and/or chlorine cleaving active ingredients, or none of said substances. The inventions also relates to the use of these agents and to a method for their production.
    Type: Application
    Filed: September 22, 2011
    Publication date: April 12, 2012
    Applicant: ECOLAB USA INC.
    Inventors: Friedrich Von Rheinbaben, Holger Biering, Klaus-Peter Bansemir, Sabine Glaeser
  • Publication number: 20120053133
    Abstract: A novel antiseptic agent composition which has a wide antimicrobial spectrum and excellent antiseptic properties is provided. An antiseptic agent composition A contains a glycerin hydroxy fatty acid monoester that is an ester of glycerin and a hydroxy fatty acid having 8 to 18 carbon atoms, and a specific antiseptic agent such as an alkanediol. An antiseptic agent composition B contains the glycerin hydroxy fatty acid monoester and an aromatic antiseptic agent. An antiseptic agent composition C contains the glycerin hydroxy fatty acid monoester and a chelating agent.
    Type: Application
    Filed: January 18, 2010
    Publication date: March 1, 2012
    Applicant: TAIYO CORPORATION
    Inventors: Shuji Kanatani, Soota Iwamoto
  • Patent number: 8106080
    Abstract: The present invention is directed to compounds, combinations, compositions and methods for enhancing nitric oxide (NO) delivery to target sites, and in particular to muscle, both normal and dystrophic. Enhanced NO delivery according to the present invention may be achieved by using a combination of a muscle relaxant and an NO donor compound, or by using a compound of the invention: formula (I) wherein R1 is H, halo, C1-6 alkoxy or C1-6 alkyl; R2 is H, NO2 or C(O)NH2; R3 is H, NO2 or C(O)NH2; and at least one of R2 and R3 is NO2; or a pharmaceutically acceptable salt of the compound.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: January 31, 2012
    Inventors: Gu-Qi Wang, Frank J Burczynski, Judith E Anderson
  • Publication number: 20120010299
    Abstract: The present invention is directed toward a method of administering an oral solution containing one or more active ingredients, preferably formulations for non-prescription medicines, vital fluids, and/or nutritional supplements, optimally dosed based upon a patient's weight. The method includes providing an oral solution having an effective amount of one or more active ingredients; determining the weight of the individual, preferably to an individual less than 12 years old; and administrating an appropriate amount of the oral solution in a single dose dispensing unit in accordance with the weight determination of the individual, whereby the total amount of active ingredient administered corresponds to an effective amount of the active ingredient based on the individual's weight.
    Type: Application
    Filed: June 27, 2011
    Publication date: January 12, 2012
    Inventors: Brian Kaplan, Robert Terwilliger, Richard Haskins, Paul Schlie
  • Publication number: 20120004310
    Abstract: Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.
    Type: Application
    Filed: May 27, 2011
    Publication date: January 5, 2012
    Inventors: Frank M. LONGO, Stephen M. Massa, Sandeep Gupta
  • Publication number: 20110312904
    Abstract: The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).
    Type: Application
    Filed: August 27, 2009
    Publication date: December 22, 2011
    Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Samuel J. Danishefsky, Ting-Chao Chou, Xiaoguang Lei, Heedong Yun, Fay Ng, John Hartung, Dalibor Sames
  • Publication number: 20110301105
    Abstract: We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.
    Type: Application
    Filed: March 30, 2011
    Publication date: December 8, 2011
    Applicant: The Hospital for Sick Children
    Inventors: Freda Miller, David Kaplan, Kristen Smith, Maryline Paris, Sibel Naska
  • Publication number: 20110281892
    Abstract: Methods and dosage formulations for the safe treatment of cold, cough, flu, and sinus symptoms in children and adolescents by age and nature of symptoms, and adults and the elderly by age, nature of symptoms, and concomitant patient medical conditions. The method of the present invention comprises the formulation of a cold medication which consists essentially of combinations of a nonsedating or minimally sedating antihistamines with pain relievers and the expectorant, guaifenesin.
    Type: Application
    Filed: May 16, 2011
    Publication date: November 17, 2011
    Inventor: Bernard Silverman
  • Patent number: 8057786
    Abstract: The present invention relates to cosmetic and/or dermatological compositions for the treatment of keratin containing substrates, comprising synergistic mixtures of modified starch polymers with defined molecular weights and cationic charges in a cosmetically acceptable medium. The synergistic mixtures of modified starches employed to manufacture compositions according to the present invention exhibit significant benefits over the existing modified starches employed according to the state-of-the-art in the treatment of keratin-containing substrates like human or animal hair, skin and nails. Another aspect of the present invention is the stabilization of the modified starch solutions used to manufacture the cosmetic and/or dermatological compositions according to the present invention against the growth of micro-organisms without traditional preservatives.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: November 15, 2011
    Assignee: Dr. Straetmans Chemische Produkte GmbH
    Inventors: Kurt Dieker, Jan Jänichen, Wilfried Petersen, Manuela Salmina-Petersen, Michael Kinder, Jessica Scholze
  • Patent number: 8053477
    Abstract: Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor suppressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: November 8, 2011
    Assignee: University of Maryland, Baltimore
    Inventors: David J. Weber, Joseph Markowitz, France Carrier, Alexander D. MacKerell
  • Publication number: 20110229542
    Abstract: An antimicrobial fabric and method for treating fabric to impart antimicrobial properties thereto by preparing an aqueous solution of eugenol, polyvinyl alcohol, and glyoxal, padding the fabric with the aqueous solution to achieve a preselected desired part by weight wet pickup, drying the fabric; and curing the fabric.
    Type: Application
    Filed: March 21, 2011
    Publication date: September 22, 2011
    Applicant: PHILADELPHIA UNIVERSITY
    Inventors: Diana R. Cundell, Alexander A. Messinger, Brian R. George, Bhalchandra Dhamankar, Ekaterina Shumilova
  • Publication number: 20110218250
    Abstract: The invention relates to compositions which comprise one or more glycerol ethers together with one or more diol/diols and/or polyol/polyols. As a result, as well as good microbicidal effectiveness, whitening is reduced or avoided, drying-out of the skin is prevented, the moisture content is regulated and the skin is regreased to an adequate extent.
    Type: Application
    Filed: May 20, 2011
    Publication date: September 8, 2011
    Applicant: AIR LIQUIDE SANTE (INTERNATIONAL)
    Inventors: WOLFGANG BEILFUSS, Sabine Wutsch, Klaus Weber, Ralf Gradtke
  • Publication number: 20110212933
    Abstract: The invention provides antiseptic compositions that comprise a wide spectrum antiseptic component (WSAC) and optionally one or more other active ingredients. The WSAC comprises an alcohol, one or more antimicrobial phenol compounds, one or more antimicrobial agents, a solvent and optionally, one or more non-ionic detergents. Additional components such as additional active agents, and thickeners can also be optionally added. The antiseptic compositions have a wide-spectrum of antiseptic activity against microorganisms and exhibit minimal toxicity and minimal irritation and can be used to treat and/or prevent dermal, mucosal, cuticle (such as nail or hoof) or genital infections in a patient.
    Type: Application
    Filed: March 20, 2008
    Publication date: September 1, 2011
    Inventor: Allan Shapiro
  • Publication number: 20110165266
    Abstract: A method of screening test chemicals or compounds as inhibitors of HIV replication is disclosed. In one embodiment, the method comprises the step of determining whether the test chemical or compound is a sulfonation inhibitor. In another embodiment, the invention is a method of treating an HIV infected individual to reduce HIV replication comprising the step of treating the individual with an effective amount of sulfonation inhibitor.
    Type: Application
    Filed: April 30, 2009
    Publication date: July 7, 2011
    Inventors: James W. Bruce, Paul G. Ahlquist, John A.T. Young
  • Publication number: 20110158920
    Abstract: A method for producing a bigel, the method comprising: (a) providing an oleogel comprising at least one oily agent gelled with at least one cellulose polymer; (b) providing an aqueous gel comprising at least one component whose viscosity is pH dependent, such as a carbomer; (c) mixing the oleogel and the aqueous gel together to form a bigel; and (d) subsequently adjusting the viscosity of the bigel under high flow and low shear stirring to obtain a bigel of a desired viscosity.
    Type: Application
    Filed: December 31, 2007
    Publication date: June 30, 2011
    Applicant: ARDANA BIOSCIENCE LIMITED
    Inventors: Timothy Morley, Julian Robert Walker Fisher
  • Patent number: 7968606
    Abstract: The present invention provides a perfume composition, which comprises at least one trimethoxybenzene in an amount of less than 0.5% by weight based on the total weight of the perfume composition. The present invention also provides a method for providing sedation in a subject, which comprises applying a perfume composition comprising at least one trimethoxybenzene in an amount of less than 0.5% by weight based on the total weight of the perfume composition to the subject.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: June 28, 2011
    Assignee: Takasago International Corporation
    Inventors: Jonathan Warr, Satomi Kunieda, Yoshiaki Numata
  • Publication number: 20110152372
    Abstract: Novel dermatological depigmentation compositions, especially for topical application, contain as pharmaceutical active agents a dissolved phenolic compound and a retinoid, formulated as anhydrous compositions free of petroleum jelly and free of elastomer. The present invention relates to a novel depigmenting composition especially for topical application, comprising as pharmaceutical active agents a dissolved phenolic derivative and a retinoid, in the form of an anhydrous composition free of petroleum jelly and free of elastomer, to the process for preparing it and to its use in dermatology.
    Type: Application
    Filed: June 2, 2009
    Publication date: June 23, 2011
    Applicant: Galderma Research & Development
    Inventors: Claire Mallard, Karine Nadau-Fourcade, Fabienne Louis
  • Publication number: 20110144213
    Abstract: Novel anhydrous dermatological depigmenting compositions, especially for topical application, contain, as pharmaceutical active agent, a phenolic compound dissolved in a fatty phase therefor.
    Type: Application
    Filed: June 2, 2009
    Publication date: June 16, 2011
    Inventors: Claire Mallard, Karine Nadau-Fourcade, Fabienne Louis
  • Publication number: 20110144127
    Abstract: Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating glaucomatous retinopathy or optic neuropathy. The structurally diverse agents that act on the Nrf2/ARE pathway induce the expression of enzymes and proteins that possess chemically versatile cytoprotective properties and are a defense against toxic metabolites and xenobiotics. Agents include certain electrophiles and oxidants such as a Michael Addition acceptor, diphenol, thiocarbamate, quinone, 1,2-dithiole-3-thione, butylated hydroxyanisole, flavonoid, an isothiocyanate, 3,5-di-tert-butyl-4-hydroxytoluene, ethoxyquin, a coumarin, combinations thereof, or a pharmacologically active derivative or analog thereof.
    Type: Application
    Filed: February 22, 2011
    Publication date: June 16, 2011
    Applicant: ALCON INC.
    Inventors: Robert A. Landers, Iok-Hou Pang
  • Publication number: 20110136669
    Abstract: The invention relates to continuous fiber layers comprising an active substance on the basis of bio-polymers, comprising a fibrous, bio-polymer active substance carrier, and at least one active substance associated with the carrier and releasable from the continuous fiber layer; to formulations comprising an active substance, said formulations comprising such continuous fiber layers; to the use of continuous fiber layers comprising an active substance for the production of formulations comprising an active substance; and to a method for the production of continuous fiber layers comprising an active substance. The invention further relates to corresponding continuous fiber layers comprising an active substance and to the use thereof for the production of wound treatment and hygiene products, and to the respectively produced wound treatment and hygiene products.
    Type: Application
    Filed: August 7, 2009
    Publication date: June 9, 2011
    Applicant: BASF SE
    Inventors: Burghard Liebmann, Evgueni Klimov
  • Publication number: 20110136851
    Abstract: The present invention is directed to a pharmaceutically acceptable taste masking liquid excipient base for administration of a relatively large amount of unpleasant tasting medicines. More particularly, the enhanced sweetness and taste masking effect are produced by the addition of sucralose to the excipient base with maintenance of a pH from about 2 to about 5. The invention is further directed to medicinal compositions comprising such a liquid excipient base and unpleasant tasting medicines. Still further, the invention is directed to a method for taste masking unpleasant tasting medicines through their incorporation into the claimed liquid excipient bases.
    Type: Application
    Filed: February 1, 2011
    Publication date: June 9, 2011
    Applicant: Wyeth LLC
    Inventors: David Jaeger, Jay Dickerson, Annabelle Trimmer
  • Publication number: 20110117048
    Abstract: Composition for application to skin comprising a biocide or combination of biocides (such as chlorhexidine, halogenated phenols, quaternary ammonium compounds; povidone-iodine; zinc pyridinethione; alcohols etc.) and at least one transcutaneous vehicle (for example alkyl methyl sulfoxides, alkyl pyrrolidones, glycols, glycol ethers and glycol esters) effective to convey the biocide to a sub epidermal “resident” micro-organism. Also a method for preparing a patient for surgery comprising the step of treating an area of the patient's skin at, and in the surrounding the vicinity of, the site of an intended surgical incision with a composition effective to kill more than 93% of both “transient” and “resident” micro-organisms.
    Type: Application
    Filed: January 20, 2011
    Publication date: May 19, 2011
    Applicant: Novapharm Research (Australia) Pty Ltd.
    Inventor: Steven Kritzler
  • Publication number: 20110054038
    Abstract: The present invention is directed to CNS pharmaceutical compositions and methods of use. The pharmaceutical compositions comprise a CNS active agent and preferably at least two vagal neuromodulators, one of which is a mechanoreceptor stimulator. The vagal neuromodulators are preferably in an amount sufficient to reduce a somnolence side-effect of the CNS active agent without changing its therapeutic efficacy/activity. The invention further encompasses a method of reducing CNS active agent side-effects. The method typically comprises oral administration of at least one CNS active agent to a patient at the conventionally accepted dose; and administration of at least two vagal neuromodulators to the patient so that at least one neuromodulator is administered or released from dosage form after the CNS active agent is administered and/or released.
    Type: Application
    Filed: August 20, 2010
    Publication date: March 3, 2011
    Applicant: TARGIA PHARMACEUTICALS
    Inventor: Sabina Glozman
  • Publication number: 20110052689
    Abstract: The invention relates to a novel pharmaceutical sustained release formulation of guaifenesin. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water-insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1: 1) to about nine-to-one (9: 1), more preferably a range of about three-to-two (3:2) to about six-to-one (6: 1), and most preferably in a range of about two-to-one (2: 1) to about four-to-one (4: 1) by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin.
    Type: Application
    Filed: November 5, 2010
    Publication date: March 3, 2011
    Applicant: RECKITT BENCKISER INC.
    Inventors: Robert D. Davis, Ralph W. Blume, Donald Jeffrey Keyser
  • Patent number: 7897647
    Abstract: Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: March 1, 2011
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Richard B. Greenwald, Annapurna Pendri
  • Patent number: 7893304
    Abstract: The present invention provides compounds that are useful for preventing or treating brain dysfunctions, motor dysfunctions, or urinary dysfunctions caused by the degeneration and/or loss of the central nervous system or peripheral nervous system cells.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: February 22, 2011
    Assignee: Meiji Dairies Corporation
    Inventors: Bang Luu, Dominique Bagnard, Mazen Hanbali, Masashi Yamada, Hiroto Suzuki
  • Publication number: 20110039874
    Abstract: Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 17, 2011
    Applicant: Northeastern University
    Inventors: Alexandros Makriyannis, Spyridon P. Nikas, Shakiru O. Alapafuja, Vidyanand G. Shukla
  • Publication number: 20110028542
    Abstract: A pharmaceutical composition for 1) increasing weight gain; and/or 2) decreasing weight loss; and/or 3) increasing appetite in a subject in need thereof, comprising purified ?-caryophyllene together with a pharmaceutically acceptable carrier. Also provided are pharmaceutical compositions for use in the prevention or treatment of Anorexia-Cachexia Syndrome, the pharmaceutical composition comprising purified ?-caryophyllene together with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: May 6, 2008
    Publication date: February 3, 2011
    Inventors: Jean Legault, Andre Pichette
  • Publication number: 20110021461
    Abstract: The present invention provides combinations of dietary supplements and methods of using of these combinations to improve the health and production performance of animals. In particular, the combinations of the invention comprise antioxidants, trace minerals, organic acids, essential amino acids, and mixtures thereof.
    Type: Application
    Filed: December 30, 2008
    Publication date: January 27, 2011
    Applicant: NOVUS INTERNATIONAL INC.
    Inventors: Mercedes Vazquez-Anon, Gavin Bowman, Steven Andrew Webb, James Richards, Robert Harrell, Junmei Zhao, Megharaja K. Manangi
  • Publication number: 20100331426
    Abstract: Disinfectant which has activity towards mycobacteria and has (a) 1-(2-ethylhexyl} glycerol ether and (b) one or more aromatic alcohols group including aryloxyalkanols, ethers and arylalkanols.
    Type: Application
    Filed: July 1, 2010
    Publication date: December 30, 2010
    Applicant: AIR LIQUIDE, SANTE (INTERNATIONAL)
    Inventors: Wolfgang BEILFUSS, Ralf GRADTKE, Wolfgang SIEGERT, Michael MOHR, Klaus WEBER
  • Publication number: 20100297215
    Abstract: Compositions, pharmaceutical preparations and methods are disclosed for protecting non-neoplastic cells from damage caused by cancer chemotherapeutic agents or radiation therapy, during the course of cancer therapy or bone marrow transplant. These are based on the use of chemoprotective inducing agents that induce or increase production of cellular detoxification enzymes in target cell populations. The compositions and methods are useful to reduce or prevent hair loss, gastrointestinal distress and lesions of the skin and oral mucosa that commonly occur in patients undergoing cancer therapy. Also disclosed is a novel assay system for identifying new chemoprotective inducing agents.
    Type: Application
    Filed: May 11, 2009
    Publication date: November 25, 2010
    Inventors: William E. Fahl, Nalini Raghavachari, Ming Zhu, John A. Kink
  • Publication number: 20100297059
    Abstract: The invention provides in part dialkoxybenzene and eugenol compounds for controlling infestation by a Lymantria dispar, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; with the provisos that when R2 is at position 2, R3 if present is at position 3, or when R2 is at position 3, R3 if present is at positions 2 or 4, or when R2 is at position 4, R3 if present is at position 2; or of Formula II: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; or mixtures thereof.
    Type: Application
    Filed: April 7, 2010
    Publication date: November 25, 2010
    Applicant: Simon Fraser University
    Inventors: Erika Plettner, Yongmei Gong, Regine Gries
  • Publication number: 20100247462
    Abstract: Processes for synthesizing resveratrol-based oligomers are provided. In addition, resveratrol-based oligomer compounds free of plant extract are provided.
    Type: Application
    Filed: September 17, 2008
    Publication date: September 30, 2010
    Inventors: Scott Alan Snyder, Steven P. Breazzano, Audrey G. Ross, Yunqing Lin, Alexandros L. Zografos
  • Publication number: 20100249244
    Abstract: The presently claimed and disclosed inventive concept(s) contemplates compositions comprising compounds, in particular dihydroeugenol (DHE) and/or isoeugenol (IE) and/or ethyl vanillin (EV) or salts, esters, ethers, or derivatives thereof, and methods for topically or systemically delivering them for treatment against inflammation-related and other dermatological conditions such as described herein. These DHE and/or IE and/or EV or salts, esters, ethers or derivatives thereof also are delivered to a measurable extent transepidermally or transdermally.
    Type: Application
    Filed: March 31, 2010
    Publication date: September 30, 2010
    Inventor: Bryan B. Fuller
  • Publication number: 20100233223
    Abstract: Provided herein are powder-free elastomeric articles exhibiting good antimicrobial and anti-blocking properties. Also provided herein are methods for the manufacture of such articles substantially free from antimicrobial interfering materials, as well as packaging means for maintaining antimicrobial efficacy.
    Type: Application
    Filed: March 9, 2010
    Publication date: September 16, 2010
    Applicant: Ansell Limited
    Inventors: Aik Hwee Eng, Hee Meng Lai, Kuang Leng Lim, Koon Meow Ting, David M. Lucas
  • Publication number: 20100227009
    Abstract: The present invention is directed to pest-controlling compositions comprising as active ingredients one or more ?-diones, particularly ?-diketones and ?-triketones, and to the use of these compositions inter alia for preventing, eradicating, destroying, repelling or mitigating harmful, annoying or undesired pests including insects, arachnids, helminths, molluscs, protozoa and viruses. The present invention is further directed to processes of preparing ?-diones by de novo synthesis or from natural sources such as volatile oil-bearing plants from families including Alliaceae, Apiaceae, Asteraceae, Cannabinaceae, Lamiaceae, Pteridaceae, Myrtaceae, Myoporaceae, Proteaceae, Rutaceae and Zingiberaceae.
    Type: Application
    Filed: May 18, 2010
    Publication date: September 9, 2010
    Applicants: BIOPROSPECT LIMITED, UNIVERSITY OF WESTERN SYDNEY
    Inventors: Robert Neil Spooner-Hart, Albert Habib Basta
  • Publication number: 20100215774
    Abstract: The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin and/or other active drugs through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.
    Type: Application
    Filed: February 8, 2008
    Publication date: August 26, 2010
    Inventor: Todd Maibach
  • Publication number: 20100204244
    Abstract: Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating diabetic retinopathy or drusen formation in age-related macular degeneration. The structurally diverse agents that act on the Nrf2/ARE pathway induce the expression of enzymes and proteins that possess chemically versatile cytoprotective properties and are a defense against toxic metabolites and xenobiotics. Agents include certain electrophiles and oxidants such as a Michael Addition acceptor, diphenol, thiocarbamate, quinone, 1,2-dithiole-3-thione, butylated hydroxyanisole, flavonoid other than genistein, an isothiocyanate, 3,5-di-tert-butyl-4-hydroxytoluene, ethoxyquin, a coumarin, combinations thereof, or a pharmacologically active derivative or analog thereof.
    Type: Application
    Filed: March 2, 2010
    Publication date: August 12, 2010
    Applicant: ALCON INC.
    Inventors: Robert A. Landers, David P. Bingaman
  • Publication number: 20100197803
    Abstract: The method for obtaining a sequoyitol-containing extract from a plant of the genus of Trifolium, Leguminosae or Ginkgoaceae, an extract obtained by the method and the use of the extract for the preparation of medicaments for treating diabetes and its complications, the method comprises the steps of extracting with a solvent, recovering the solvents to give an extractum, subjecting the extractum to two-phase extraction and column chromatography, collecting the fractions containing sequoyitol, concentrating, filtration and drying.
    Type: Application
    Filed: May 28, 2008
    Publication date: August 5, 2010
    Applicant: LIANCHUANGSIYUANLI BIOLOGY AND SCIENCE AND TECHNOLOGY CO., LTD
    Inventors: Tianyu Sun, Yanli Wang, Guixing Deng, Yinyin Wang, You Lu, Ting Wang
  • Publication number: 20100184858
    Abstract: The progression of hepatic fibrosis and hepatic cirrhosis caused by various hepatic disorders and damages such as chronic hepatitis can be restrained by hepatic fibrosis inhibitor containing a compound represented by the following chemical formula: wherein, R1 represents an alkyl group with a carbon number of 4 to 8, and R2 represents a hydrogen atom, alkylcarbonyl group with a carbon number of 2 to 6, or alkoxycarbonyl group with a carbon number of 2 to 6.
    Type: Application
    Filed: December 7, 2009
    Publication date: July 22, 2010
    Inventors: Naohisa Ishikawa, Satoru Sugiyama, Tokutaro Miki, Hiroshi Nishikawa
  • Publication number: 20100166726
    Abstract: Methods and compositions that increase the cellular uptake of a chemotherapeutic agent are provided. Also provided are methods of increasing access to the cell surface by antibodies and ligands. The methods are useful in treating any mucinous carcinoma characterized by an increased expression and/or secretion of mucins. In addition, these methods provide an improvement in existing methods of chemotherapy.
    Type: Application
    Filed: March 7, 2008
    Publication date: July 1, 2010
    Applicant: NORTHEASTERN UNIVERSITY
    Inventor: Robert B. Campbell
  • Publication number: 20100160432
    Abstract: A compound is prepared based on Formula 1: wherein, R1 represents an alkyl group with a carbon number of 4 to 8, and R2 represents a hydrogen atom, alkylcarbonyl group with a carbon number of 2 to 6 or alkoxycarbonyl group with a carbon number of 2 to 6. A curative drug for neurodegenerative diseases can be prepared principally from the compound or a hydroquinone derivative consisting of a cyclodextrin inclusion compound thereof. The curative drug for neurodegenerative diseases has a safe and beneficial effect of inhibiting nerve cell disorder due to oxidative stress, thereby to stop progression of symptoms.
    Type: Application
    Filed: February 24, 2010
    Publication date: June 24, 2010
    Inventors: Satoru Sugiyama, Tokutaro Miki, Hiroshi Nishikawa
  • Publication number: 20100160451
    Abstract: The invention provides in part dialkoxybenzene compounds for controlling infestation by a Trichoplusia ni, and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl(3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; except that when R2 is at position 2, R3 if present is at position 3, and when R2 is at position 3, R3 if present is at positions 2 or 4, and when R2 is at position 4, R3 if present is at position 2, and when R2 is at position 4 and R3, if present, has reacted with an OH group at position 1 in a Markovnikov sense, then R3 becomes R4, a dihydrofuran.
    Type: Application
    Filed: November 19, 2009
    Publication date: June 24, 2010
    Applicants: Simon Fraser University, The University of British Columbia
    Inventors: Erika Plettner, Murray Bruce Isman
  • Patent number: 7708990
    Abstract: The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effect in maintaining health in humans and animals. By using a composition which comprises a coenzyme Q being a mixture of a reduced coenzyme Q and an oxidized coenzyme Q with the proportion of the reduced coenzyme Q to the whole coenzyme Q of more than 95% by weight, the present invention can attain a high maximum blood concentration of a coenzyme Q as well as long maintenance of high concentration of coenzyme Q in blood for a prolonged period of time, and the area under the blood concentration curve (AUC) can be expanded.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: May 4, 2010
    Assignee: Kaneka Corporation
    Inventors: Kenji Fujii, Taizo Kawabe, Hiroshi Kubo
  • Publication number: 20100093650
    Abstract: A composition for inhalation, comprising at least: a) an effective amount of an antimicrobial aminoglycoside derivative or a salt thereof, and b) an effective amount of a biofilm modifier which is a macrolide derivative or a salt thereof.
    Type: Application
    Filed: October 11, 2007
    Publication date: April 15, 2010
    Applicant: LABORATORIES SMB S.A.
    Inventors: Philippe Baudier, Francis Vanderbist, Arthur Deboeck