Plural Oxygens Patents (Class 514/718)
  • Patent number: 5854254
    Abstract: Methods for achieving human male contraception are described in which compounds that substantially inhibit the movement of mannose lectins on the surface of human male sperm cells are administered to human male patients, and the inhibition achieved provides a reversible infertility that can serve as a means of birth control. The use of calcium (Ca.sup.+2) ion channel blocking pharmaceutical compositions is described, particularly the drugs nifedipine, verapamil, and calcium ionophore A23187.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: December 29, 1998
    Assignee: North Shore University Hospital
    Inventor: Susan H. Benoff
  • Patent number: 5840724
    Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: November 24, 1998
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Garry Fenton, Andrew David Morley, Malcolm Norman Palfreyman, Andrew James Ratcliffe, Brian William Sharp, Keith Alfred James Stuttle, Sukanthini Thurairatnam, Bernard Yvon Jack Vacher
  • Patent number: 5834521
    Abstract: Tetracyclic compounds having the following structure are described: ##STR1## wherein R.sub.1 -R.sub.10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antiovulatory effects and potent steroid receptor binding. The compounds have therapeutic utility in reproductive applications such as fertility control, labor induction, ovulation induction and spermatogenesis. Methods for preparing the tetracyclic compounds from substituted indanones are also described.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: November 10, 1998
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: John H. Dodd, Lisa A. Dixon, James L. Bullington, Charles F. Schwender
  • Patent number: 5824666
    Abstract: The present invention relates to leave on, oil-in-water, skin care compositions, comprising: (A) from about 0.05% to about 20% of an acidic active ingredient, preferably having a solubility parameter from about 6 to about 12; (B) from about 0.1% to about 25% of alkoxylated alcohols, alkoxylated polyols, and mixtures thereof; (C) from about 1% to about 20% of an acid stable, hydrophobic, structuring agent selected from the group consisting of saturated C.sub.16 to C.sub.30 fatty alcohols, saturated C.sub.16 to C.sub.30 fatty alcohols containing from about 1 to about 5 moles of ethylene oxide, saturated C.sub.16 to C.sub.30 diols, saturated C.sub.16 to C.sub.30 monoglycerol ethers, saturated C.sub.16 to C.sub.30 hydroxy fatty acids, and mixtures thereof, having a melting point of at least about 45.degree. C.; (D) from about 0.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: October 20, 1998
    Assignee: The Procter & Gamble Company
    Inventors: George Endel Deckner, Marie Antoinette Rinaldi, Victoria Claire Szymanski
  • Patent number: 5763449
    Abstract: A liquid pharmaceutical composition is contemplated that comprises a pharmaceutically effective amount of a bitter tasting drug dissolved or dispersed in an aqueous medium that is free of ethanol. That aqueous medium consists essentially of water, about 5 to about 30 weight percent polyvinylpyrrolidone, about 45 to about 55 weight percent of a C.sub.3 -C.sub.6 polyol, about 0.01 to about 0.5 weight percent ammonium glycyrrhizinate and one or more flavorants. The liquid composition is transparent and has a pleasant taste.
    Type: Grant
    Filed: August 7, 1996
    Date of Patent: June 9, 1998
    Assignee: Ascent Pediatrics, Inc.
    Inventors: Aloysius O. Anaebonam, Emmett Clemente, Abdel A. Fawzy
  • Patent number: 5741525
    Abstract: Gelled vaginal pharmaceutical composition containing:a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: April 21, 1998
    Assignee: Marshall University Research Corporation
    Inventor: Bryan Larsen
  • Patent number: 5725875
    Abstract: A protective cream composition contains 15 to 40 wt % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount of a topical agent such as an antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 to 8.0 wt. %, of an alkali metal silicate, and the balance water. Such a composition can be applied to the skin to protect health care workers and other from infection. The cream dries to form a topical barrier on the skin, and also contains an agent effective against, for instance, viruses such as human HIV. Once a medical operation is completed, the film formed from the dried cream can be washed off with soap and water. Other topical agents present in the composition include, for instance, suncreens, insect repellents and chemical repellents.
    Type: Grant
    Filed: January 2, 1996
    Date of Patent: March 10, 1998
    Assignee: Microbarriers
    Inventors: Charles R. Noll, Virginia M. Noll
  • Patent number: 5705194
    Abstract: There is disclosed a pharmaceutical composition which gels at physiological temperature. The composition is comprised of a block copolymer containing one or more polyoxyethylene blocks and one or more polyoxy (higher alkylene) blocks wherein at least some of the blocks are linked together by a linking group characterised in that the linking group is an oxymethylene group, and a therapeutic agent. The therapeutic agent is present as (i) nanoparticles of the therapeutic agent having the block copolymer adsorbed on the surface thereof, (ii) a suspension in a solution of the block copolymer, or (iii) as an aqueous solution in a solution of the block copolymer.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: January 6, 1998
    Assignee: NanoSystems L.L.C.
    Inventors: Sui-Ming Wong, Eugene R. Cooper, Shuqian Xu
  • Patent number: 5679696
    Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 21, 1997
    Assignee: Rhone-Poulenc Rorer Limited
    Inventors: Garry Fenton, Andrew David Morley, Malcolm Norman Palfreyman, Andrew James Ratcliffe, Brian William Sharp, Keith Alfred James Stuttle, Sukanthini Thurairatnam, Bernard Yvon Jack Vacher
  • Patent number: 5663207
    Abstract: Gem-Dichlorocyclopropanes (Analog II derivatives) which demonstrate antiproliferative activity toward MCF-7 cells, in vitro and are generally not reversed by estradiol or having intrinsic estrogenicity (except the hydroxyphenyl derivative Compound 30). In general the cyclopropane compounds have the formula: ##STR1## or any pharmaceutically acceptable salt thereof. X is selected from a group consisting of hydrogen and halogen atoms. The group R.sub.1 may he a hydrogen atom, an alkyl group, an acyl group, or an arylalkyl group. The group R.sub.2 may be a hydrogen atom, an unsubstituted aryl group or a substituted aryl group. The group R.sub.3 may be a hydrogen atom, an alkyl group, a cycloalkyl group, a substituted aryl group or an unsubstituted aryl group. The group R.sub.4 may be a hydrogen atom, an unsubstituted aryl group or a substituted aryl group. The R.sub.4 is absent when R.sub.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: September 2, 1997
    Assignee: Research Corporation Technologies
    Inventors: Robert A. Magarian, Joseph T. Pento, May T. Griffin
  • Patent number: 5654329
    Abstract: Compounds of the formula ##STR1## where W is (CH.sub.2).sub.n where n is 1 or 2, or n is 0 and W represents lower alkyl groups attached to each oxygen;m is an integer between 1 and 8;R.sub.1 is COOH or a pharmaceutically acceptable salt thereof, COOR.sub.4, CONR.sub.5 R.sub.6, CONR.sub.5 SO.sub.2 R.sub.7, CH.sub.2 OH, CH.sub.2 OR.sub.7, CH.sub.2 O--COR.sub.7, CH.sub.2 O--CONR.sub.5 R.sub.7, CH.sub.2 OCOOR.sub.7, CH.sub.2 NH.sub.2, CH.sub.2 NR.sub.5 R.sub.6, CH.sub.2 NR.sub.5 COR.sub.7, CHO, CH(OR.sub.8).sub.2, CH(OR.sub.9 O), --COR.sub.10, CR.sub.10 (OR.sub.8).sub.2, or CR.sub.10 OR.sub.9 O, where R.sub.4 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.4 is phenyl or lower alkylphenyl, R.sub.5 and R.sub.6 independently are hydrogen, an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or phenyl or lower alkylphenyl, R.sub.7 is alkyl of 1 to 10 carbons, phenyl or lower alkylphenyl, R.sub.8 is lower alkyl, and R.sub.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 5, 1997
    Assignee: Allergan
    Inventors: Robert M. Burk, David F. Woodward
  • Patent number: 5633284
    Abstract: Dermatological compositions comprising nitrous oxide and at least one essential fatty acid or lower alkyl ester thereof in a dermatologically acceptable carrier medium is useful in the treatment of a variety of skin, muscle and joint disorders including psoriasis, shingles, fever blisters, chicken pox, ache, chilblains, eczema, chloasmas, alopecia, dermatitis, ringworm and burn wounds. The composition preferably also includes additional ingredients selected from coal tar, collagen, nicotinamide, nicotinic acid, lanolin, vitamin E, methyl salicylate, arnica, and H.sub.1 -antagonist antihistamines or combinations thereof.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: May 27, 1997
    Assignee: Pitmy International N.V.
    Inventor: Petrus J. Meyer
  • Patent number: 5565188
    Abstract: There is disclosed a composition containing nanoparticles having a surface modifier wherein the surface modifier is a block copolymer containing one or more polyoxyethylene blocks and one or more polyoxy(higher alkylene) blocks wherein at least some of the blocks are linked together by a linking group characterized in that the linking group is an oxymethylene group.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: October 15, 1996
    Assignee: NanoSystems L.L.C.
    Inventors: Sui-Ming Wong, Eugene R. Cooper, Shugian Xu
  • Patent number: 5563177
    Abstract: There is provided a taste masked liquid pharmaceutical composition for administration of a relatively large amount of unpleasant tasting medicines. More particularly, the composition comprises a taste masking liquid excipient base for administration of relatively large amounts of unpleasant tasting medicines, said excipient base having higher than normal viscosities due to a combination of a normally solid polyethylene glycol and sodium carboxymethylcellulose.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: October 8, 1996
    Assignee: American Home Products Corporation
    Inventors: Shankar D. Popli, Zenaida O. Go
  • Patent number: 5563129
    Abstract: There are disclosed novel hydroquinone derivatives of the formula: ##STR1## The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: October 8, 1996
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hirotomo Masuya, Masayoshi Yamaoka
  • Patent number: 5508275
    Abstract: Lipid-selective antioxidants of the formula I(A).sub.a (L)(X).sub.a, (I),in whichA=an antioxidative component,L=a bridging member,X=a lipophilic componenta and a'=independently of one another the numbers 1 or 2.The compounds are used for the protection of lipid-containing substances against oxidation and in pharmaceuticals for the prophylaxis and treatment of diseases in which bioradicals are involved, in particular of coronary, circulatory and vascular diseases.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: April 16, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus-Ulrich Weithmann, Gunther Wess, Dirk Seiffge
  • Patent number: 5492917
    Abstract: Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, inflammatory diseases including Raynaud's disease and asthma.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: February 20, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Ralph A. Rivero, Peter D. Williams, Daniel F. Veber
  • Patent number: 5492687
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkylene ethers and pharmaceutically acceptable clays in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: February 20, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, Edward R. Bacon
  • Patent number: 5466435
    Abstract: Disclosed are contrast agents of the formula ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy;(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H or lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl;in an aqueous, pharmaceutically acceptable carrier comprising a cellulose derivative.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: November 14, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward J. Baker, Edward R Bacon, Carl R. Illig, Thomas J. Caulfield, Brent D. Douty, Kurt A. Josef, John L. Toner, Robert W. Lee
  • Patent number: 5447710
    Abstract: The present invention is directed to a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.The present invention is also directed to a method for making nanoparticles comprising(i) contacting said nanoparticle containing an x-ray diagnostic compound with a high molecular weight nonionic surfactant for a time and under conditions sufficient to form a nanoparticle with the surfactant adsorbed on the surface thereof; and(ii) contacting the so treated nanoparticle with a cloud point modifier for a time and under conditions sufficient to form a nanoparticle containing an x-ray diagnostic compound, having a nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: September 5, 1995
    Assignee: Eastman Kodak Company
    Inventors: George C. Na, Natarajan Rajagopalan
  • Patent number: 5437633
    Abstract: A method of treating a subject in cardiac arrest, comprises blocking the descending aorta of the subject and then perfusing the aortic arch of the subject with a protective solution. The protective solution is one capable of delivering oxygen to the heart of said subject, such-as a perfluorochemical blood substitute. Following perfusion, spontaneous circulation is restored.In an improved embodiment of the foregoing, a vasoconstrictor such as epinephrine is administered concurrently with the perfusing step in an amount effective to enhance coronary perfusion with said protective solution.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: August 1, 1995
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: James E. Manning
  • Patent number: 5432147
    Abstract: The present invention provides a method for controlling fungal disease in cultivated crops. The aqueous fungicide formulation which is applied to pre-harvest and post-harvest crops contains ingredients which are biocompatible for purposes of agricultural and horticultural applications. Illustrative of a formulation which is harmless to animals and humans is an aqueous solution having a content of potassium bicarbonate, potassium carbonate, nonionic surfactant and xanthan gum. The combination of nonionic surfactant and xanthan gum functions as an effective spreader-sticker medium for forming a film-like coating on plant surfaces. The adherent coating exhibits both immediate and long duration fungicidal activities.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: July 11, 1995
    Assignee: Church & Dwight Co., Inc.
    Inventors: Anthony E. Winston, Alfredo Vinci
  • Patent number: 5393789
    Abstract: The invention relates to a disinfectant concentrate which includes amine and alcohol and is characterized in that the alcohol component includes at least one aromatic alcohol and the amine component includes at least one tertiary alkyl amine which is free of hydroxyl groups. It is also relates to a disinfectant which is preparable from the disinfectant concentrate, and to the use of the disinfectant concentrate or disinfectant as a bactericide, in particular a Mycobactericide, fungicide or virucide.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: February 28, 1995
    Assignee: Eastman Kodak Company
    Inventors: Heinz Eggensperger, Lower Bernd, Michael Mohr, Peter Goroncy-Bermes, Wolfgang Beilfuss
  • Patent number: 5389386
    Abstract: The present invention provides a method for controlling fungal disease in cultivated crops. The aqueous fungicide formulation which is applied to pre-harvest and post-harvest crops contains ingredients which are biocompatible for purposes of agricultural and horticultural applications. Illustrative of a formulation which is harmless to animals and humans is an aqueous solution having a content of potassium bicarbonate, potassium carbonate, nonionic surfactant and xanthan gum. The combination of nonionic surfactant and xanthan gum functions as an effective spreader-sticker medium for forming a film-like coating on plant surfaces. The adherent coating exhibits both immediate and long duration fungicidal activities.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: February 14, 1995
    Assignee: Church & Dwight Co., Inc.
    Inventors: Anthony E. Winston, Alfredo Vinci
  • Patent number: 5387611
    Abstract: This invention relates to methods of abrogating sperm motility utilizing the anti-bacterial, anti-viral agents butylurea, Nonoxynol-9 and benzalkonium chloride. This invention is further directed to anti-bacterial, anti-viral, non-irritating contraceptive compositions, and to methods of enhancing contraceptive capabilities of conventional contraceptive means as well as to enhanced conventional contraceptive means.
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: February 7, 1995
    Assignee: Albert Einstein College of Medicine of Yeshiva University, a Division of Yeshiva University
    Inventor: Arye Rubinstein
  • Patent number: 5385942
    Abstract: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: January 31, 1995
    Assignee: Eisai Co., Ltd.
    Inventors: Shinya Abe, Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Junichi Nagakawa, Kazuo Hirota, Ieharu Hishinuma, Kaname Miyamoto, Takashi Yamanaka, Hiromitsu Yokohama, Tsutomu Yoshimura, Tohru Horie, Yasunori Akita, Koichi Katayama, Isao Yamatsu
  • Patent number: 5370876
    Abstract: A protective cream composition contains 15 to 40 wt. % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount an antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 to 8.0 wt. %, of an alkali metal silicate, and the balance water. Such a composition can be applied to the skin to protect health care workers and others from infection. The cream dries to form a topical barrier on the skin, and also contains an agent effective against, for instance, viruses such as human HIV. Once a medical operation is completed, the film formed from the dried cream can be washed off with soap and water.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: December 6, 1994
    Assignee: Microbarriers
    Inventors: Charles R. Noll, Virginia M. Noll
  • Patent number: 5354739
    Abstract: Highly concentrated emulsifiable concentrates of neophanes and azaneophanes for use in plant protectionHighly concentrated emulsifiable concentrates of compounds of the general formula I ##STR1## in which A, B=independently of one another CH, CR.sub.4 or N,X=CH.sub.2, O or S,Y=CH or N,Z=H or F,R.sub.1 and R.sub.4 =independently of one another H, halogen, (C.sub.1 -C.sub.3)-alkyl, (C.sub.1 -C.sub.3)-halogenoalkyl, (C.sub.1 -C.sub.3)-alkoxy, (C.sub.1 -C.sub.3)-halogenoalkoxy, (C.sub.1 -C.sub.4)-alkylthio or (C.sub.1 -C.sub.4)-halogenoalkylthio, or R.sub.1 and R.sub.4 together=--CH.sub.2 --O--CH.sub.2 --;R.sub.2 =H, (C.sub.1 -C.sub.3)-alkyl, ethynyl, vinyl, halogen or cyano,R.sub.3 =H, halogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.3)-alkoxy andM=C or Si, which contain a combination of an anionic and a nonionic emulsifier with a (C.sub.2 -C.sub.16)-alkanol.also have, in addition to a very good spontaneous emulsiliability, a very high emulsion stability.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: October 11, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Hans Rochling
  • Patent number: 5348576
    Abstract: An antifouling composition for coating fishnets consisting essentially of (A) at least one phenol compound represented by the formula: ##STR1## or the formula: ##STR2## (in which Y is hydrogen atom or hydroxyl group; ##STR3## m is 0 or 1; n is an integer of 1-5; R is a linear or branched alkyl having 4 to 21 carbon atoms), (B) at least one water-repellent organic compound selected from silicone oil, petroleum wax and liquid paraffins, and (C) at least one antifouling agent selected from fluorodichloromethyl thiophthalimide, dimethylphenyl fluorodichloromethyl thiosulfamide and dichlorophenyl dimethyl urea, the amount of said (C) being 0.5-20 wt % of the total of (A)+(B)+(C).The present antifouling composition is specifically effective for the prevention of attachment, and proliferation of noxious aquatic organisms including both of an animal and botanical nature.
    Type: Grant
    Filed: March 11, 1992
    Date of Patent: September 20, 1994
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Junji Yokoi, Akio Harada
  • Patent number: 5348727
    Abstract: A compound of the formula: ##STR1## wherein Z.dbd.H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, wherein thealkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R.dbd.C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p -(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C-Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H, or lower-alkyl, optionally substituted with halo;x is 1-4;n is [1-5]1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, these compounds are useful as X-ray contrast agents or aryl-lower alkyl.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: September 20, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward R. Bacon, Carl R. Illig, Thomas J. Caulfield, Brent D. Douty, Kurt A. Josef
  • Patent number: 5340564
    Abstract: This invention discloses a composition comprised of nanoparticles having p-isononylphenoxypoly (glycidol) as a surface modifier adsorbed on the surface thereof. In preferred embodiments, the p-isononylphenoxypoly (glycidol) provides resistance to particle aggregation during heat sterilization. In another preferred embodiment, those nanoparticles also comprise a stability enhancing compound. A preferred stability enhancing compound is albumin. This invention further discloses a method of making nanoparticles having p-isononylphenoxypoly(glycidol) as a surface modifier adsorbed on the surface, comprised of contacting said nanoparticles with p-isononylphenoxypoly(glycidol) for a time and under conditions sufficient to form a p-isononylphenoxypoly(glycidol) surface modified nanoparticle.
    Type: Grant
    Filed: December 10, 1992
    Date of Patent: August 23, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Kathleen J. Illig, Pramod Sarpotdar
  • Patent number: 5332581
    Abstract: A keratinous fiber treating composition comprising the following components (a) and (b), and an acid. ##STR1## The keratinous fiber treating composition according to the present invention makes it possible to impart a good elasticity to the hair without causing any damage (for example, dryness, stiffness and splitting) thereof.
    Type: Grant
    Filed: August 28, 1992
    Date of Patent: July 26, 1994
    Assignee: Kao Corporation
    Inventors: Toru Yoshihara, Takayoshi Kajino, Emi Chugun
  • Patent number: 5326552
    Abstract: The present invention is directed to a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.The present invention is still further directed to a method for diagnostic imaging for use in medical procedures comprising administering to the body of a test subject in need of an X-ray an effective contrast producing amount of a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: July 5, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: George C. Na, Natarajan Rajagopalan
  • Patent number: 5310538
    Abstract: R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 =CR.sub.4).sub.m Q ,or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2 and R.sub.3 and R.sub.4 are independently H, or lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-4;m is 1-15;p is 1-20; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkylThese compounds are combined in a polymer for use as an X-ray contrast agent.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: May 10, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Edward R. Bacon, Carl R. Illig, Thomas J. Caulfield, Brent D. Douty, Kurt A. Josef
  • Patent number: 5302619
    Abstract: Aromatic compounds are disclosed of the formula: ##STR1## wherein R.sup.1 is a C.sub.3 -C.sub.8 alkyl group, a C.sub.3 -C.sub.8 alkoxy group, an alkoxyalkyl group having 3 to 8 carbon atoms, a C.sub.3 -C.sub.8 alkenyl group, a C.sub.3 -C.sub.8 alkenyloxy group, an alkenyloxyalkyl group having 3 to 8 carbon atoms, a C.sub.3 -C.sub.8 haloalkyl group, a C.sub.3 -C.sub.8 haloalkoxy group, a haloalkoxyalkyl group having 3 to 8 carbon atoms, a C.sub.3 -C.sub.8 haloalkenyl group, a C.sub.3 -C.sub.8 haloalkenyloxy group, a haloalkenyloxyalkyl group having 3 to 8 carbon atoms or a C.sub.3 -C.sub.8 alkynyloxy group; R.sup.2 is a halogen atom; R.sup.3 groups are the same or different and each is a hydrogen atom, a halogen atom or a methyl group; R.sup.4 is a hydrogen atom or a methyl group; R.sup.5 groups are the same or different and each is a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 haloalkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 haloalkoxy group, a C.sub.
    Type: Grant
    Filed: February 28, 1992
    Date of Patent: April 12, 1994
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Akira Shuto, Noriyasu Sakamoto, Hirosi Kisida, Hiroaki Fujimoto, Kimitoshi Umeda, Noritada Matsuo
  • Patent number: 5279813
    Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula.
    Type: Grant
    Filed: August 18, 1992
    Date of Patent: January 18, 1994
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Richard S. Robinson, Jeffrey Miller, Chimpiramma Potini, Michael A. Collins, Theresa G. Shackil
  • Patent number: 5274002
    Abstract: Novel trisubstituted phenyl analogs are now found to have activity as for the treatment of congestive heart failure.
    Type: Grant
    Filed: September 6, 1990
    Date of Patent: December 28, 1993
    Assignee: Warner-Lambert Company
    Inventor: Lynn D. Hawkins
  • Patent number: 5273741
    Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.
    Type: Grant
    Filed: July 30, 1992
    Date of Patent: December 28, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaftar, Richard S. Robinson, Jeffrey Miller, Chimpiramma Potini, Michael A. Collins, Theresa G. Shackil
  • Patent number: 5262441
    Abstract: An aromatic compound of the formula: ##STR1## wherein R.sup.1 is a C.sub.3 -C.sub.8 alkyl group, a C.sub.3 -C.sub.8 alkoxy group, an alkoxyalkyl group having 3 to 8 carbon atoms, a C.sub.3 -C.sub.8 alkenyl group, a C.sub.3 -C.sub.8 alkenyloxy group, an alkenyloxyalkyl group having 3 to 8 carbon atoms, a C.sub.3 -C.sub.8 haloalkyl group, a C.sub.3 -C.sub.8 alkoxy group, a haloalkoxyalkyl group having 3 to 8 carbon atoms, a C.sub.3 -C.sub.8 haloalkenyl group, a C.sub.3 -C.sub.8 haloalkenyloxy group, a haloalkenyloxyalkyl group having 3 to 8 carbon atoms or a C.sub.3 -C.sub.8 alkynyloxy group; R.sup.2 is a halogen atom; R.sup.3 is, the same or different, a hydrogen atom, a halogen atom or a methyl group; R.sup.4 is a hydrogen atom or a methyl group R.sup.5 is, the same or different, a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 haloalkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 haloalkoxy group, a C.sub.1 -C.sub.4 alkylthio group, a C.sub.1 -C.sub.
    Type: Grant
    Filed: September 28, 1992
    Date of Patent: November 16, 1993
    Assignee: Sumitomo Chemical Company Limited
    Inventors: Akira Shuto, Noriyasu Sakamoto, Hirosi Kisida, Hiroaki Fujimoto, Kimitoshi Umeda, Noritada Matsuo
  • Patent number: 5252610
    Abstract: An aromatic compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are, the same or different, a hydrogen atom, a halogen atom or a methyl group with the proviso that either one of R.sup.1 or R.sup.2 is a hydrogen atom; R.sup.3 is a hydrogen atom or a methyl group; and R.sup.4 is a halogen atom, a C.sub.1 -C.sub.2 alkyl group or a C.sub.1 -C.sub.2 haloalkyl group, which is useful for control of insect pests.
    Type: Grant
    Filed: February 28, 1992
    Date of Patent: October 12, 1993
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Noriyasu Sakamoto, Akira Shuto, Hiroshi Kisida, Hiroaki Fujimoto, Kimitoshi Umeda
  • Patent number: 5219568
    Abstract: A pharmaceutical composition for the treatment of hoarseness. The composition is administered orally in unit dosage form. It is based on the combination of Varidase (a combination of streptokinase and streptodornase), an antiinflammatory corticosteroid, an antihistamine and an expectorant. The composition may optionally contain vitamins, like vitamin B.sub.1 or Vitamin B.sub.2. The invention further relates to a method for the treatment of hoarseness in humans, which comprises administering an effective quantity of a composition as defined above.
    Type: Grant
    Filed: April 6, 1990
    Date of Patent: June 15, 1993
    Inventor: Israel Nageris
  • Patent number: 5216032
    Abstract: A method of treating a subject in cardiac arrest, comprises blocking the descending aorta of the subject and then perfusing the aortic arch of the subject with a protective solution. The protective solution is one capable of delivering oxygen to the heart of said subject, such as a perfluorochemical blood substitute. Following perfusion, spontaneous circulation is restored.In an improved embodiment of the foregoing, a vasoconstrictor such as epinephrine is administered concurrently with the perfusing step in an amount effective to enhance coronary perfusion with said protective solution.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: June 1, 1993
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: James E. Manning
  • Patent number: 5204108
    Abstract: A drug delivery composition comprising a plurality of microspheres and active drug associated with each microsphere, the drug being for systemic delivery and having a maximum molecular weight of 6000, and the composition being substantially free of an enhancer. The microspheres may be of starch, gelatin or albumin. Suitable drugs include peptides, such as insulin, and antigenic vaccine ingredients. The compositions are suitable for delivery across a mucosal surface such as the vagina, eye or nose.
    Type: Grant
    Filed: April 9, 1990
    Date of Patent: April 20, 1993
    Assignee: Danbiosyst UK Ltd.
    Inventor: Lisbeth Illum
  • Patent number: 5185145
    Abstract: The invention relates to a disinfectant concentrate containing 10 to 60% by weight of phenoxyethanol or a phenoxypropanol mixture of 2-phenoxy-1-propanol and 1-phenoxy-2-propanol in a ratio by weight of from 1:4 to 1:20, 0.1 to 50% by weight of a cationic compound selected from the group of the guanidinium compounds, quaternary ammonium compounds or mixtures of these, 3 to 25% by weight of non-ionic surfactants and 0.1 to 10% by weight of an organic nitrogen-containing base having a pK.sub.B value of .gtoreq.4.75.
    Type: Grant
    Filed: February 21, 1991
    Date of Patent: February 9, 1993
    Assignee: Eastman Kodak Company
    Inventors: Heinz Eggensperger, Karl-Heinz Diehl, Helmut Nolte, Helmut Rackur, Ute Eggers-Maass, Michael Mohr, Lower Bernd, Wolfgang Beilfuss
  • Patent number: 5180742
    Abstract: Quinone derivatives of the general formula: ##STR1## (wherein R.sup.1 and R.sup.2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R.sup.1 and R.sup.2 combine with each other to represent --CH.dbd.CH--CH.dbd.CH--R.sup.3 is a hydrogen atom or a methyl group; R.sup.4 is an aliphatic, aromatic or heterocyclic group which may be substituted; R.sup.5 is a methyl or methoxy group, a hydroxymethyl group which may be substituted or a carboxyl group which may be esterified or amidated; Z is a group represented by --C.dbd.C--, --CH.dbd.CH--, ##STR2## n is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, possess metabolism ameliorating action for polyunsaturated fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity), thromboxane A.sub.
    Type: Grant
    Filed: January 9, 1987
    Date of Patent: January 19, 1993
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Shinji Terao, Yoshitaka Maki
  • Patent number: 5177108
    Abstract: Aryloxyalkanol derivatives having the formulaAr--O(CH.sub.2).sub.n OHwherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treatment of a retrovirus infection.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: January 5, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Roger A. Parker, Sai P. Sunkara
  • Patent number: 5158775
    Abstract: A suspension type aerosol inhalations containing (a) 0.015 to 5.00% (w/w) of a pyrido[1,2-a]pyrimidine compound of the formula: ##STR1## where R is a n-propyl or allyl group, A is a tetrazolyl or carboxyl group, and n is a whole number of 0 to 2, and (b) 0.015 to 5.00% (w/w) of a fatty acid ester.
    Type: Grant
    Filed: June 14, 1990
    Date of Patent: October 27, 1992
    Assignee: Tokyo Tanabe Company, Limited
    Inventors: Takashi Yazaki, Yukio Goto
  • Patent number: 5158977
    Abstract: A 5,6,7,8-tetrahydro-1-naphthalenol derivative of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent lower alkyl,R.sub.5 and R.sub.6 represent hydrogen or lower alkyl,R represents hydrogen, C.sub.1 -C.sub.18 alkyl, C.sub.2 -C.sub.18 alkyl substituted by one or more hydroxyl groups, C.sub.3 -C.sub.18 alkenyl, C.sub.2 -C.sub.18 acyl, benzyl, benzoyl, carboxyl and carboxylic salts of an alkali or alkaline earth metal or of an organic amine.The derivative is useful as an antioxidant in cosmetic compositions and in pharmaceutical compositions for the preventive treatment of cutaneous inflammations and allergies or certain forms of cancer.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: October 27, 1992
    Assignee: L'Oreal
    Inventors: Jean Maignan, Gerard Malle, Andre Deflandre, Gerard Lang
  • Patent number: 5154747
    Abstract: An antifouling composition for use in the control of noxious aquatic life comprising as an active ingredient, one or more phenol derivatives of the formula ##STR1## wherein R is a C.sub.3 .about.C.sub.21 saturated hydrocarbon residue; X.sub.1 .about.X.sub.5 each is H, HO or CH.sub.3 O, providing excluding the case wherein all of X.sub.1 .about.X.sub.5 are hydrogen.This composition is useful as an antifouling paint for marine structures, ships, fishnets, buoys, industrial water system, water cooling system and the like.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: October 13, 1992
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Junji Yokoi, Akio Harada, Kazuo Ina
  • Patent number: RE34440
    Abstract: A benzonaphthalene compound has the formula ##STR1## wherein R.sub.1 represents ##STR2## or (ii) --CH.sub.2 OH; R.sub.6 represents ##STR3## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' or r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or a sugar, or together form a heterocycle; R.sub.2 represents hydrogen, alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radial; R.sub.3 represents hydrogen, hydroxy, alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical, a thiocycloaliphatic radical or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents lower alkyl; and R.sub.4 and R.sub.5 represent hydrogen, lower alkyl, hydroxy or lower acyloxy.This compound is useful in the topical and systemic treatment of dermatologic diseases and in the treatment of the degeneration of conjunctive tissues.
    Type: Grant
    Filed: July 16, 1992
    Date of Patent: November 9, 1993
    Assignee: Centre International de Recherches Dermatologiques (C.I.R.D.)
    Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon