Vitamin A Compound Or Derivative Patents (Class 514/725)
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Patent number: 8197854Abstract: A nutritional supplement for use in physiologically stressful conditions is disclosed. The nutritional supplement may include one or more of vitamin A, vitamin E, vitamin D3, vitamin C, vitamin B1, riboflavin, niacin, folic acid, vitamin B6, biotin, pantothenic acid, vitamin B12, magnesium, zinc, selenium, chromium, copper, iron, alpha lipoic acid, lutein and lycopene.Type: GrantFiled: March 7, 2011Date of Patent: June 12, 2012Assignee: Vertical Pharmaceuticals, Inc.Inventors: Steven A. Squashic, Kevin M Hudy, David C. Purdy
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Publication number: 20120141576Abstract: Retinal and its derivatives are incorporated with liposomes in therapeutic compositions for topical application to prevent or alleviate the conditions and symptoms of cosmetic and dermatologic disorders are described as follows. In particular, retinal and its derivatives are combined with liposomes to increase the penetration of the retinal into the skin, to provide hydration of the skin during treatment, to reduce irritation of the skin during the application of the retinal, for use as a chemical skin peel and other embodiments and uses. The present invention includes utilizing retinol products, and particularly retinal in combination with liposomes each of these embodiments and uses separately as well as in combinations with one another.Type: ApplicationFiled: March 15, 2007Publication date: June 7, 2012Inventor: Benjamin Johnson
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Patent number: 8183227Abstract: The present invention relates to compositions, kits and methods for the administration of various vitamin, mineral and nutrient compositions, and in a specific embodiment, the compositions, kits and methods may utilize or include vitamin D, iodine, vitamin B1, vitamin B6, vitamin B12, vitamin B2, vitamin B9, vitamin B3, vitamin E, vitamin A, vitamin C, iron, zinc, copper, magnesium, omega 3 fatty acids and one or more pharmaceutically acceptable carriers.Type: GrantFiled: November 9, 2011Date of Patent: May 22, 2012Assignee: Chemo S. A. FranceInventors: Philippe Perrin, Guillaume Herry
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Patent number: 8178124Abstract: An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.Type: GrantFiled: September 29, 2011Date of Patent: May 15, 2012Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Junji Kato, Yasushi Sato
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Publication number: 20120114625Abstract: Shelf-stable fermented dairy products and methods of making the shelf-stable fermented dairy products are provided. The shelf-stable fermented dairy products can be shelf-stable with improved taste, viscosity and texture profiles. In a general embodiment, the present disclosure provides a shelf-stable fermented dairy product including a shelf-stable fermented dairy component, a stabilizer, and a puree composition. The shelf-stable fermented dairy component can be, for example, yogurt, sour cream, buttermilk or a combination thereof.Type: ApplicationFiled: April 23, 2010Publication date: May 10, 2012Inventors: Ana Lucia Wiessel, Allen Bruce Zerlaut, Frank Karl Welch
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Patent number: 8173170Abstract: An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.Type: GrantFiled: December 22, 2005Date of Patent: May 8, 2012Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Junji Kato, Yasushi Sato
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Publication number: 20120108672Abstract: An ophthalmic composition characterized by comprising (A) vitamin A, (B) a polyoxyethylene polyoxypropylene glycol, and at least one component selected from (C) trometamol, (D) polyhydric alcohols, (E) a sugar, (F) phosphoric acid and salt thereof and (G) monovalent neutral salts.Type: ApplicationFiled: June 23, 2010Publication date: May 3, 2012Inventors: Hazuki Tsutsui, Miyuki Miyake, Akito Odaka, Chieko Inoue, Nobuhito Tabuchi, Manabu Hattori
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Publication number: 20120108658Abstract: Disclosed is an ophthalmic composition which is characterized by containing (A) a vitamin A, (B) a polyoxyethylene polyoxypropylene glycol, and (C) an oil component that is selected from the group consisting of castor oil, soybean oil, sesame oil, peanut oil, olive oil, almond oil, wheat germ oil, corn oil, rapeseed oil, sunflower oil, purified lanolin and gel hydrocarbon.Type: ApplicationFiled: June 29, 2010Publication date: May 3, 2012Inventors: Akito Odaka, Chieko Inoue, Manabu Hattori, Nobuhito Tabuchi
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Patent number: 8168611Abstract: The present invention relates to compositions, kits and methods for the administration of various vitamin, mineral and nutrient compositions, and in a specific embodiment, the compositions, kits and methods may utilize or include twelve carbon chain fatty acids and/or twelve carbon chain acylglycerols, vitamin D, iodine, vitamin B1, vitamin B6, vitamin B12, vitamin B2, vitamin B9, vitamin B3, vitamin E, vitamin A, vitamin C, iron, zinc, copper, magnesium, omega 3 fatty acids and one or more pharmaceutically acceptable carriers.Type: GrantFiled: September 29, 2011Date of Patent: May 1, 2012Assignee: Chemo S.A. FranceInventors: Philippe Perrin, Guillaume Herry, Cecile Boyer-Joubert
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Publication number: 20120101156Abstract: A composition including a retinoid, an NF?B-inhibitor, and a cosmetically-acceptable topical carrier is provided. Methods of treating the skin are also provided.Type: ApplicationFiled: October 25, 2010Publication date: April 26, 2012Inventor: Thierry Oddos
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Publication number: 20120100077Abstract: Disclosed is a mixture of amphipathic molecules and a method for modifying cells in vivo by way of membrane fusion with these molecules.Type: ApplicationFiled: July 8, 2010Publication date: April 26, 2012Applicant: FORSCHUNGSZENTRUM JUELICH GMBHInventors: Bernd Hoffmann, Agnes Csiszar, Nils Hersch, Rudolf Merkel
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Patent number: 8148431Abstract: It is intended to provide an osteogenesis promoter having a remarkable effect of positively promoting osteogenesis and thus preventing/treating bone diseases; a preventive/a remedy for bone diseases such as osteoporosis having both of an osteogenesis-promoting effect and a bone resorption-inhibiting effect; and a method of screening an active ingredient for preventing/treating bone diseases by using a compound having both of an osteogenesis-promoting effect and a bone resorption-inhibiting effect as a lead compound. It is confirmed that beta-cryptoxanthin, which occurs in a large amount in peel and sarcocarp of satsuma orange, has an osteogenesis-promoting effect and a therapeutic effect on bone disease. Thus, beta-cryptoxanthin or its composition is used as an osteogenesis promoter, a preventive/a remedy for bone diseases, a functional food or a food material for preventing/treating bone diseases and a feed composition.Type: GrantFiled: October 3, 2003Date of Patent: April 3, 2012Assignee: Kemin Health, L.C.Inventor: Masayoshi Yamaguchi
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Patent number: 8143215Abstract: Compositions for enhancing satiety and weight loss in an individual, assays for assessing a tastant for enhancing satiety and weight loss, and methods of using the composition to suppress appetite and enhance weight loss are provided.Type: GrantFiled: January 16, 2009Date of Patent: March 27, 2012Inventor: Alan R. Hirsch
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Publication number: 20120070422Abstract: A method wherein subjects having or at risk for having hyperopia, presbyopia or astigmatism are administered a composition having an effective amount of ocular antioxidants, including specifically macular pigments, to prevent, treat, or delay the onset of age-related macular degeneration (AMD).Type: ApplicationFiled: September 21, 2011Publication date: March 22, 2012Applicant: KEMIN INDUSTRIES, INC.Inventor: Richard Roberts
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Publication number: 20120064149Abstract: The present invention relates to hexylresorcinol/water concentrates that are high in clarity, easily handled, and readily blended with other ingredients to form skin care compositions.Type: ApplicationFiled: November 17, 2011Publication date: March 15, 2012Inventors: Kalonda Tymika Johnson, John Lemmo, Michael Southall, Ping Wen
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Publication number: 20120065232Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold.Type: ApplicationFiled: October 27, 2011Publication date: March 15, 2012Applicant: HALLSTAR INNOVATIONS CORP.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20120046354Abstract: A method for treating or preventing oral cavity mucosal disorders, comprising a step of providing a lozenge containing an antioxidant selected from the group of Vitamin A, Vitamin C, Vitamin E; and other ingredients and a step of placing the lozenge within the oral cavity for a period of time required for dissolution of the lozenge.Type: ApplicationFiled: August 18, 2010Publication date: February 23, 2012Inventor: Eli D. Ehrenpreis
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Publication number: 20120028933Abstract: A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Laboratory experiments have demonstrated the use of cell-guard agents and/or target-specific supplements in the bioprocessing of cells as well as in selecting out a desired cell population. Several potential additive agents (both natural and synthetic) have been identified during these studies, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery.Type: ApplicationFiled: July 28, 2011Publication date: February 2, 2012Inventors: John M. Baust, John G. Baust, William L. Corwin, Robert G. Van Buskirk
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Patent number: 8106094Abstract: This invention relates to methods and compositions for treating and ameliorating skin conditions including post inflammatory hyperpigmentation (PIH). More particularly, this invention relates to compositions containing certain natural extracts, salicylic acid, and natural or synthetic retinoids. The composition was clinically proven to reduce PIH.Type: GrantFiled: July 30, 2004Date of Patent: January 31, 2012Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Archana Sah, Victoria Dole, Glenn Nystrand, Miri Seiberg, Jue-Chen Liu, Ellen Kurtz
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Patent number: 8105618Abstract: Dermatological/cosmetic gel compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise (i) at least one retinoid, (ii) dispersed benzoyl peroxide and (iii) at least one pH-independent gelling agent, formulated into (iv) a physiologically acceptable medium therefor.Type: GrantFiled: September 17, 2010Date of Patent: January 31, 2012Assignee: Galderma Research & DevelopmentInventors: Sandrine Orsoni-Segona, Nathalie Willcox
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Patent number: 8101587Abstract: The present invention relates to methods of co-administration of various vitamin and mineral compositions, and in a specific embodiment, said methods comprise co-administering one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states; and kits provided for co-administration of various vitamin and mineral compositions, and in a specific embodiment, said kits comprise one composition comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and a second composition comprising omega-3 fatty acids such as DHA, to supplement the nutritional needs of individuals within physiologically stressful states.Type: GrantFiled: April 10, 2009Date of Patent: January 24, 2012Assignee: Everett Laboratories, Inc.Inventors: John A. Giordano, Charles J. Balzer
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Publication number: 20120015014Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.Type: ApplicationFiled: September 23, 2011Publication date: January 19, 2012Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Noa LAPIDOT, Shlomo Magdassi, David Avnir, Claudi Rottman, Orit Gans, Alon Seri-Levy
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Patent number: 8093293Abstract: This invention relates to methods and compositions for treating and ameliorating skin conditions including acne, rosacea and wrinkling caused by photodamage or intrinsic aging. More particularly, this invention relates to compositions containing certain natural extracts and natural or synthetic retinoids.Type: GrantFiled: September 10, 2003Date of Patent: January 10, 2012Assignee: Johnson & Johnson Consumer Companies, Inc.Inventors: Miri Seiberg, Jue-Chen Liu, Violetta Iotsova
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Publication number: 20120003181Abstract: The present invention describes a novel retinoid-responsive nucleic acid, and a novel protein. Further, the invention describes the use of such a nucleic acid or protein in various diseases, and for the treatment, the diagnosis and prognosis of various diseases, and also for a method for the prognosis of responsiveness to retinoids.Type: ApplicationFiled: June 9, 2009Publication date: January 5, 2012Inventors: Johan R. Lillehaug, Pendino Frederic
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Publication number: 20110318321Abstract: The present invention relates to a controlled release pharmaceutical or food formulation comprising at least one active pharmaceutical or food ingredient dispersed in a mixture of a glycogen with a polysaccharide, and the process for its preparation. The invention also relates to a slow release system represented by a mixture of a glycogen with a polysaccharide, and its use for the preparation of slow release pharmaceutical or food formulations.Type: ApplicationFiled: January 8, 2010Publication date: December 29, 2011Applicant: AZIENDE CHIM.RIUN.ANG.FRANC.A.C.R.A.F. S.p.A.Inventors: Stefano Selva, Leonardo Marchitto, Giovanni Battista Ciottoli, Lorella Ragni, Vincenzo Russo, Elisa Liberati
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Publication number: 20110311442Abstract: A lipid vesicle comprising a phospholipid which is a stable vesicle former and at least one unstable vesicle forming member, wherein the unstable vesicle forming member is selected from the group consisting of a polar lipid which is not a stable vesicle former, a PEG, a raft former and a fusion protein is provided. The vesicle can further comprise a biomolecule, such as for example ATP. Methods of using the vesicle for delivery of biomolecules are also provided.Type: ApplicationFiled: June 17, 2011Publication date: December 22, 2011Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: William D. Ehringer, Sufan Chien
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Publication number: 20110281946Abstract: The present invention concerns polymeric-based compositions that are useful in the delivery and sustained release of hydrophobic therapeutic and/or cosmetic agents substantially at the point of injury, infection or, in the case of purely cosmetic applications, the point of treatment. Also provided are methods of preparing such compositions and methods of treatments involving the use of such compositions.Type: ApplicationFiled: May 11, 2011Publication date: November 17, 2011Applicant: NORTHERN HYDROGELS LTDInventor: Alan John WADDON
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Publication number: 20110280964Abstract: A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.Type: ApplicationFiled: April 21, 2011Publication date: November 17, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Josef Miller, Colleen LePrell, Jochen Schacht, Diane Prieskorn
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Publication number: 20110275712Abstract: An oil in water emulsion cosmetic composition for skin, in which vitamin A and its derivatives are stably incorporated and which has superior feeling in use (skin familiarity or feeling of skin absorption, feeling of efficacy after application) and base composition stability (emulsion stability) with the passage of time. The oil in water emulsion cosmetic composition for skin comprises, relative to the total amount of the cosmetic composition, (a) from 0.01 to 4% by mass of vitamin A and its derivative, (b) from 0.6 to 4% by mass of a nonionic surfactant comprising three of (b-1) sorbitan tristearate, (b-2) polyethylene glycol stearate with from 20 to 120 mols of polyethylene glycol added thereto, (b-3) glyceryl stearate having an HLB of from 5 to 8, and (c) from 1 to 10% by mass of a higher alcohol having from 14 to 24 carbon atoms, wherein the blend ratio (by mass) of component (b-1) to component (b) is from 0.1 to 0.8.Type: ApplicationFiled: July 8, 2009Publication date: November 10, 2011Applicant: SHISEIDO COMPANY, LTD.Inventors: Kazutaka Sasaki, Manabu Shimoda, Yoshihito Takakura, Haruhiko Inoue, Shigeru Mugikura
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Publication number: 20110262550Abstract: A method for treating a skin ailment by applying a personal composition from a collapsible dispenser. The collapsible dispenser includes a collapsible bag at least partially surrounded by an elastically deformable member and, optionally, an outer container body. Potential energy is generated by stretching the elastically deformable member, which is used to dispense the composition in lieu of a propellant or pump. The personal care composition may be a skin care composition, an antifungal, or an enzyme inhibiting composition.Type: ApplicationFiled: April 26, 2010Publication date: October 27, 2011Inventors: Thomas James Klofta, Gary Dean Lavon, Thomas Edward Schulte
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Patent number: 8039020Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.Type: GrantFiled: June 18, 2010Date of Patent: October 18, 2011Assignee: Sol-Gel Technologies Ltd.Inventors: Noa Lapidot, Shlomo Magdassi, David Avnir, Claudio Rottman, Orit Gans, Alon Seri-Levy
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Publication number: 20110251242Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from resveratrol compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of resveratrol compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the resveratrol compound is concentration dependent, with the amount of resveratrol photostabilization increasing with the concentration of the alkoxycrylene compound.Type: ApplicationFiled: April 5, 2011Publication date: October 13, 2011Applicant: HALLSTAR INNOVATIONS CORP.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20110251273Abstract: This invention relates to compositions containing a retinoid and use of the compositions for treating skin conditions.Type: ApplicationFiled: December 22, 2009Publication date: October 13, 2011Inventors: Thierry Oddos, Linda Fournier, Gaelle Bellemere, Sébastien Saclier, Anne-Sophie Brillouet
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Patent number: 8034799Abstract: Methods are provided for reducing copper values for, by way of example, treating, preventing or ameliorating tissue damage such as, for example, tissue damage that may be caused by (i) disorders of the heart muscle (for example, cardiomyopathy or myocarditis) such as idiopathic cardiomyopathy, metabolic cardiomyopathy which includes diabetic cardiomyopathy, alcoholic cardiomyopathy, drug-induced cardiomyopathy, ischemic cardiomyopathy, and hypertensive cardiomyopathy, (ii) atheromatous disorders of the major blood vessels (macrovascular disease) such as the aorta, the coronary arteries, the carotid arteries, the cerebrovascular arteries, the renal arteries, the iliac arteries, the femoral arteries, and the popliteal arteries, (iii) toxic, drug-induced, and metabolic (including hypertensive and/or diabetic disorders of small blood vessels (microvascular disease) such as the retinal arterioles, the glomerular arterioles, the vasa nervorum, cardiac arterioles, and associated capillary beds of the eye, the kidneyType: GrantFiled: September 7, 2005Date of Patent: October 11, 2011Assignee: Philera New Zealand LimitedInventors: Garth J. S. Cooper, John R. Baker
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Patent number: 8030360Abstract: A medicament having an anti-wrinkle action, which comprises as an active ingredient a retinoid having a fundamental structure of a phenyl substituted carbamoyl benzoic acid or a phenyl substituted carboxamide benzoic acid (for example, 4-(3,5-bis(trimethylsilyl)phenylcarboxamide) benzoic acid, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid, or the like).Type: GrantFiled: February 29, 2008Date of Patent: October 4, 2011Assignee: Kemphys Ltd.Inventors: Koichi Shudo, Seishiro Fujii
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Publication number: 20110236502Abstract: The vitamin strip is made with gel, film, or dissolvable material safe for human consumption. It can encompass all the vitamins, minerals, medicines, or meal replacement elements safe for human intake. The vitamin strip (V1) can be made as a whole or as a strip of edible dissolvable material with any vitamin(s), mineral(s), medicine(s), or meal replacement element(s) safe for human consumption on the strip of edible dissolvable material.Type: ApplicationFiled: March 29, 2010Publication date: September 29, 2011Inventor: Joseph Marcel Guillory
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Publication number: 20110229559Abstract: Methods of producing a controlled release formulation for an active substance are disclosed, wherein the methods involve dispersing a discontinuous phase comprising an active substance into a continuous phase so as to form a two-phase liquid system comprising droplets of said discontinuous phase, and allowing nanoparticles provided to the two-phase liquid system to congregate at the phase interface to thereby coat the surface of the droplets in at least one layer of said nanoparticles. The methods utilise a concentration of a suitable electrolyte which enhances the nanoparticle congregation such that the coating of nanoparticles on the surface of the droplets presents a semi-permeable barrier to the active substance, or otherwise utilise a amount of the active substance that is greater than the solubility limit of that active substance in the discontinous phase. Formulations comprising vitamin A (retinol) as the active substance for dermal delivery are specifically exemplified.Type: ApplicationFiled: March 28, 2011Publication date: September 22, 2011Applicant: University of South AustraliaInventors: Clive Allan Prestidge, Spomenka Simovic, Nasrin Ghouchi Eskandar
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Publication number: 20110229540Abstract: A cosmetic formulation comprising porous silicon is described.Type: ApplicationFiled: September 30, 2009Publication date: September 22, 2011Inventors: Leigh Canham, Tanya Monga
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Publication number: 20110206756Abstract: Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) a dithiocarbamate metal chelate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. Methods for using the compositions in anticancer treatment and prevention are also described herein.Type: ApplicationFiled: March 16, 2009Publication date: August 25, 2011Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATIONInventors: Paul J. Shami, Ken M. Kosak, Thomas Kennedy
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Publication number: 20110206626Abstract: A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of a combination of retinoid boosters.Type: ApplicationFiled: April 29, 2011Publication date: August 25, 2011Applicant: CONOPCO, INC., D/B/A UNILEVERInventors: Stewart Paton Granger, Ian Richard Scott, Robert Mark Donovan, Susanne Teklits Iobst, Lisa Licameli
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Publication number: 20110189249Abstract: A low pH composition containing a retinol and a method for treating skin is disclosed. The composition contains (a) a retinoid and (b) an active acid, like an alpha-hydroxy acid or a beta-hydroxy acid, and has a pH of less than 5.Type: ApplicationFiled: September 9, 2009Publication date: August 4, 2011Applicant: AMCOL INTERNATIONAL CORPORATIONInventors: Limin Liu, Ralph Spindler, Gholam-Reza Vakili-Tahami
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Publication number: 20110177951Abstract: The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.Type: ApplicationFiled: August 2, 2009Publication date: July 21, 2011Applicant: SOL-GEL TECHNOLOGIES LTD.Inventors: Ofer Toledano, Hanan Sertchook, Natalia Loboda, Raed Abu-Reziq
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Publication number: 20110171281Abstract: A clear soft vegetarian dosage capsule comprising a first and second biphasic film. The first biphasic film has a plurality of first reservoirs and further comprises a polysaccharide, a seaweed extract, a rheology modifier, a buffer and a plasticizer. The second biphasic film has a plurality of second reservoirs having a formulation identical to the first film to ensure a sealing engagement. A dosage amount is disposed in each of the plurality of the reservoirs forming a plurality of filled reservoirs. The dosage amount is an emulsion, oil, hydrophilic liquid. The first film is extruded or overlaid with the second film allowing each of the plurality of second reservoirs to overlay the filled reservoirs and sealed with pressure and a fusion temperature slightly less than the melting point of the first and second films forming clear soft vegetarian dosage capsules that are blown dry, bonding moisture to the polysaccharide.Type: ApplicationFiled: January 14, 2010Publication date: July 14, 2011Inventor: Karl Wei Cao
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Patent number: 7976854Abstract: A treatment regimen for treating skin subject to skin cancer treatments involves the application of supplemental composition(s) such as preparatory composition(s), protective composition(s), and combinations thereof, and a corrective composition.Type: GrantFiled: December 29, 2006Date of Patent: July 12, 2011Assignee: OMP, Inc.Inventors: Judy Hattendorf, Steve Carlson
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Patent number: 7976879Abstract: A product and method for administering daily micronutrient requirements (DMRs) comprising vitamins, minerals and essential fatty acids targeted to reduce appetite and/or the risks associated with aging and associated cognitive impairment. The DMRs are administered to individuals via food products. In an embodiment of the present invention, the DMRs are offered in the form of a health bar, smoothie, or drink. The DMRs may be incorporated into other forms without departing from the scope of the present invention. By way of illustration and not as a limitation, the constituents may be incorporated into a fruit or yogurt “smoothie,” a frozen desert such as an ice cream or sorbet, and a beverage.Type: GrantFiled: July 23, 2009Date of Patent: July 12, 2011Inventor: Michael F. Roizen
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Patent number: 7968594Abstract: The present invention relates to treatment of cancer related pain and constipation. Preferably the subject in need is administered a combination of the cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC). More preferably the cannabinoids are in a predefined ratio by weight of approximately 1:1 of CBD to THC.Type: GrantFiled: April 27, 2005Date of Patent: June 28, 2011Assignee: GW Pharma LimitedInventors: Geoffrey Guy, Philip Robson
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Patent number: 7968600Abstract: A medicament for preventive and/or therapeutic treatment of a physical dysfunction such as motor dysfunction caused by nerve damage resulting from an accident, cerebral crisis and the like, which comprises as an active ingredient a compound or a salt thereof represented by the following general formula (I): wherein R1 to R5 represents hydrogen atom, an alkyl group, or an alkyl-substituted silyl group, X represents —CONH— or —NHCO—, and A represents a carboxylic acid-substituted aromatic group which may be substituted or a tropolonyl group which may be substituted.Type: GrantFiled: February 1, 2007Date of Patent: June 28, 2011Assignees: Nanoegg Research Laboratories, Inc., Kemphys Ltd.Inventors: Mitsuko Takenaga, Koichi Shudo, Tetsuro Matsuishi, Miwako Ishido
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Publication number: 20110150968Abstract: A strip, which is both edible and dissolvable, is provided comprising a film and a dosage of at least 2% of the reference daily intake (RDI) of at least one dietary supplement for malnutrition or to prevent/treat alcohol induced hangovers. A method for treating malnutrition and/or preventing and treating alcohol-induced hangovers using a dissolvable orally administered strip.Type: ApplicationFiled: June 18, 2010Publication date: June 23, 2011Inventor: Alessandra Grassi
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Publication number: 20110152372Abstract: Novel dermatological depigmentation compositions, especially for topical application, contain as pharmaceutical active agents a dissolved phenolic compound and a retinoid, formulated as anhydrous compositions free of petroleum jelly and free of elastomer. The present invention relates to a novel depigmenting composition especially for topical application, comprising as pharmaceutical active agents a dissolved phenolic derivative and a retinoid, in the form of an anhydrous composition free of petroleum jelly and free of elastomer, to the process for preparing it and to its use in dermatology.Type: ApplicationFiled: June 2, 2009Publication date: June 23, 2011Applicant: Galderma Research & DevelopmentInventors: Claire Mallard, Karine Nadau-Fourcade, Fabienne Louis
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Patent number: 7964202Abstract: Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, said dermatological/cosmetic composition having physical stability without loss of viscosity over time at a temperature ranging from 4° C. to 40° C., said dermatological/cosmetic composition having a stable flow threshold over time as measured by viscosity measurements for rheograms which measure a shear stress ? for a given rate gradient ? and which measure a rate gradient ? for a given shear stress ?, the yield value (?0) being extrapolated visually or by calculation.Type: GrantFiled: March 24, 2008Date of Patent: June 21, 2011Assignee: Galderma Research & Development, S.N.C.Inventors: Sandrine Orsoni, Nathalie Willcox