C Of C-o- Group Is Nuclear C Of A Benzene Ring (e.g., Phenol, Phenolate, Etc.) Patents (Class 514/728)
  • Patent number: 7101910
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: September 5, 2006
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 6992111
    Abstract: A fungicidal composition and method of treating plant diseases using a compound of formula I where X is flouro, chloro and trifluromethyl.
    Type: Grant
    Filed: September 2, 2004
    Date of Patent: January 31, 2006
    Assignee: Valent BioSciences Corporation
    Inventors: Daniel F. Heiman, Peter D. Petracek, Judith A. Fugiel, Prem Warrior
  • Patent number: 6964782
    Abstract: Disclosed are several preferred embodiments of hydrogen peroxide which are packaged with ease of use and extended shelf-life in mind. The embodiments include foam, mist, gel, and disposable towelette forms of H2O2. Optional ingredients of topical pain relievers and skin protectants are also disclosed, as are their methods of use.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: November 15, 2005
    Assignee: Tec Labs, Inc.
    Inventors: Robert Lee Smith, Steven Dale Smith, Wendy S. Langley, John Mark Christensen, Vernon W. Smith
  • Patent number: 6855341
    Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: February 15, 2005
    Inventor: Jeffrey B. Smith
  • Patent number: 6841578
    Abstract: The invention features a method for the treatment or prevention of mucositis in an individual undergoing or preparing to undergo cancer treatment. The method includes administering a therapeutically effective amount of an inhibitor of NF-?B to an individual undergoing or preparing to undergo a treatment for cancer. In certain embodiments, the inhibitor is a compound having the formula: where R1 and R4 are OH, and R2 and R3 are independently OH or H, provided that when R1 and R2 are both OH, R1 and R2 cannot be disposed ortho to one another, and when R3 and R4 are both OH, R3 and R4 cannot be disposed ortho to one another. The compounds of formula I may be cis or trans.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: January 11, 2005
    Inventor: Stephen T. Sonis
  • Publication number: 20040176319
    Abstract: Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed “small molecules” into the cells of mammalian tissue, such as the epithelial cells of the mucosa.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 9, 2004
    Applicant: Aesgen, Inc.
    Inventors: Robert G. Petit, Esward C. Shinal
  • Patent number: 6723754
    Abstract: The use of COMT inhibitors in the treatment of control of pain in mammals, for example in animals and humans.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: April 20, 2004
    Assignee: Orion Corporation
    Inventors: Päivi Aho, Inge-Britt Lindén
  • Patent number: 6720314
    Abstract: Methods for performing a capsulorhexis are disclosed wherein a dye is used to stain a lens capsule of an eye. The dye is capable of staining tissue without diffusing through the tissue. Compositions including dyes that are useful in the methods are also disclosed.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: April 13, 2004
    Inventor: Gerrit Reinold J. Melles
  • Publication number: 20040043993
    Abstract: Compounds of formula (I), wherein R 5 is an [A]—CH 3 , —[A]—C(OH)ZZ′ or —[A]—C(O) Z″ grouping where —[A]— is an alkylene, alkenylene or alkynylene radical or a single bond, and Z, Z′ and Z″ are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl radical; and R 1, R 2, R 3, R 4, R 6, R 7 and R 8 are as defined in the description; the use thereof as a drug, pharmaceutical compositions containing same, a preparation method therefor, and intermediates of said method, are disclosed.
    Type: Application
    Filed: July 8, 2002
    Publication date: March 4, 2004
    Applicant: Aventis Pharma S.A.
    Inventors: Dominique Lesuisse, Jean-Georges Teutsch
  • Patent number: 6699911
    Abstract: A process is provided for the preparation of cyclohexene derivatives of general formula I or II: in which the substituents R1 and R2 independently of one another are defined as follows: R1 is R2 is OH or a protective group convertible to a hydroxyl group by hydrolysis; R3 and R4 are hydrogen or C1-C4-alkyl; and R5 is hydrogen or C1-C4-acyl, by the reduction of alkyne compounds of general formula III or IV: in which the substituents R1 and X are as defined above, wherein the reducing agent used is a mixture of zinc and at least one compound B selected from the group consisting of ammonium salts, copper salts and alkali metal and alkaline earth metal salts.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: March 2, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Johannes Grimmer, Thomas Müller, Hansgeorg Ernst
  • Patent number: 6696430
    Abstract: A method for performing retinal membrane removal is disclosed using vital dyes which are applied to the membrane. Compositions including vital dyes which are useful in the retinal membrane removal methods are also disclosed.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: February 24, 2004
    Inventor: Gerrit Reinold Jacob Melles
  • Patent number: 6689922
    Abstract: The invention concerns novel bi-aromatic compounds having the formula: which are analogs of vitamin D, the process of preparing them, as well as their use in pharmaceutical compositions in human or veterinary medicine, particularly in dermatology, cancer treatment, treatment of auto-immune diseases, and in organ or tissue transplants. Cosmetic compositions and methods of use are also included.
    Type: Grant
    Filed: July 26, 2001
    Date of Patent: February 10, 2004
    Assignee: Galderma Research & Development S.N.C.
    Inventor: Jean-Michel Bernardon
  • Patent number: 6664297
    Abstract: The inhibition of the formation and development of amyloidoses, as well as the dissolution of amyloidoses in organisms is claimed. Methods for the diagnosis of amyloidoses using aromatic and heteroaromatic compounds having at least one electron-withdrawing groups are claimed.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: December 16, 2003
    Assignee: Universidade Federal do Rio de Janeiro
    Inventors: Sergio Teixeira Ferreira, Fernanda Guarino De Felice, Paulo Roberto Ferreira Louzada, Jr.
  • Patent number: 6656919
    Abstract: The present invention is directed to a method for the disinfection and sterilization of material and surfaces contaminated with one or more members selected from the group consisting of bacteria and bacterial spores, comprising the steps of: (a) providing a biocidal fluid containing a mixture of effective amounts of a germinant and a germicide; and (b) contacting the material and surfaces contaminated with one or more members selected from the group consisting of bacteria and bacterial spores, with the biocidal fluid of step (a) for a time sufficient for disinfecting and sterilizing said material. The invention also provides a sterilizing composition suitable for killing and rendering spores lifeless comprising: (a) an effective amount of a germinating agent; (b) an effective amount of a germicide.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: December 2, 2003
    Inventors: Clarence L. Baugh, Thomas E. Baugh, Charles L. Baugh
  • Patent number: 6646000
    Abstract: A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to plants, increasing crop yields, controlling certain plant diseases, controlling arthropod, bacterial, fungal, mycoplasma, rickettsia, and viral pests of animals and humans, and disinfecting inanimate surfaces. The method utilizes the unique multi-directional dispersion property of the tannate complex of picro ammonium formate and the tannate complex of picro cupric ammonium formate, in aqueous solution, combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate, to penetrate plant and animal systems and inanimate surfaces and travelling multidirectionally therein. The method is carried out by introducing a small but effective amount of the tannate complex to the plant or animal system or inanimate surface.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: November 11, 2003
    Inventor: Will H. Hartfeldt
  • Patent number: 6646013
    Abstract: The instant invention provides a combination of multiple nutrients useful to reduce colon rectal cancer in a mannalian or human subject. Further, the combination provides synergistic ratios of the useful nutrients.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: November 11, 2003
    Assignee: Nutri-Logics
    Inventors: Anna D. Barker, Robert W. Day, Anthony J. Dennis, Norman R. Farnsworth, Julie A. Haack, Joseph M. McCord, John D. Potter
  • Patent number: 6641800
    Abstract: Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer soluble in the liquefied hydrofluoroalkane which is selected from polymers including recurring amide containing structural units, copolymers of amide containing units and carboxylic acid ester units, polyvinylacetate and acrylic acid/methacrylic acid ester copolymers.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: November 4, 2003
    Assignee: Fisons Ltd.
    Inventors: Suresh N Mistry, Mark Gibson
  • Publication number: 20030203484
    Abstract: The present invention relates to methods of inducing differentiation of mammalian bone marrow stromal cells into neuronal cells by contacting marrow stromal cells with a neuronal differentiation-inducing compounds. Neuronal differentiation-inducing compounds of the invention include anti-oxidants such as, but not limited to, beta-mercaptoethanol, dimethylsulfoxide, butylated hydroxyanisole, butylated hydroxytoluene, ascorbic acid, dimethylfumarate, and n-acetylcysteine. Once induced to differentiate into neuronal cells, the cells can be used for cell therapy, gene therapy, or both, for treatment of diseases, disorders, or conditions of the central nervous system.
    Type: Application
    Filed: August 6, 2002
    Publication date: October 30, 2003
    Applicants: Philadelphia Health And Education Corporation, University of Medicine and Dentistry of New Jersey
    Inventors: Ira B. Black, Dale L. Woodbury, Darwin J. Prockop, Emily Schwarz
  • Patent number: 6572843
    Abstract: A method for treating hair, combining permanent dyeing and straightening of hair, without significantly damaging the hair. According to the method of the present invention the hair is treated by chemically reducing covalent disulfide linkages in the hair, and contacting said hair with at least one oxidoreductase, at least one mediator, and at least one chemical oxidizing agent in an amount equivalent to 0.001-1% hydrogen peroxide calculated by weight of the dyeing formulation.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: June 3, 2003
    Assignee: Novozymes, A/S
    Inventors: Niels Henrik Sorensen, Jason Patrick McDevitt
  • Publication number: 20030069316
    Abstract: The invention is related to the use of COMT inhibitors in the treatment or control of pain.
    Type: Application
    Filed: September 13, 2002
    Publication date: April 10, 2003
    Inventors: Paivi Aho, Inge-Britt Linden
  • Publication number: 20030053955
    Abstract: An insect pest eradication system comprised of a non-lethal knockout agent and an insecticide. The present invention also relates to a method of eradicating insects, particularly those found in earthen colonies, by treating the insects with a non-lethal knockout agent, such as trans-dichloroethylene, in combination with a suitable insecticide for the targeted insects.
    Type: Application
    Filed: October 2, 2001
    Publication date: March 20, 2003
    Inventor: Tommy G. Taylor
  • Patent number: 6469070
    Abstract: A topical medicament for the treatment of warts, corns and verrucae including a phenolic biocide, which is preferably a compound of formula (I), in which n is from 0 to 19, in combination with choline or a derivative or a salt thereof. A method for treatment of warts, corns and verrucae is also provided which includes the steps of applying the topical medicament to the warts, corns and verrucae.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: October 22, 2002
    Assignee: Biominerals, N.V.
    Inventor: Dirk Vanden Berghe
  • Patent number: 6461591
    Abstract: A pressure-liquefied propellant mixture for aerosols, comprising a fluorinated alkane, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, and carbon dioxide, makes possible an improvement of the wetting properties of pharmaceutically active compounds, with which the formulation problems existing with hydrofluoroalkanes in relation to suspension as well as solution aerosols can be overcome and thus improved medicinal aerosol formulations can be obtained. With the aid of carbon dioxide, it is also possible to specifically influence the pressure and thus the particle size distribution and also by displacement of oxygen from the hydrofluoroalkanes to improve the storage stability of oxidation-sensitive active compounds.
    Type: Grant
    Filed: August 4, 1999
    Date of Patent: October 8, 2002
    Assignee: Jago Research AG
    Inventors: Manfred Keller, Kurt Herzog
  • Patent number: 6462044
    Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: October 8, 2002
    Assignee: NitroMed, Inc.
    Inventors: David S. Garvey, Inigo Saenz de Tejada, Richard A. Earl, Subhash P. Khanapure
  • Patent number: 6444699
    Abstract: An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid and may advantageously be formulated to have a pH above 3.5. Generally, the composition also includes non-toxic zinc salt, tyrosine compound, and/or pharmaceutically acceptable carrier. In addition, the composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. The topical composition may be in the form of a serum, a hydrophilic lotion, an ointment, a cream, or a gel.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: September 3, 2002
    Assignee: Bioderm, Inc.
    Inventor: Lorraine Faxon Meisner
  • Patent number: 6433021
    Abstract: Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: August 13, 2002
    Assignee: Venantius Limited
    Inventors: Neil Frankish, Helen Sheridan, John Walsh, Michael Jordan
  • Patent number: 6403652
    Abstract: A method for inhibiting methicillin drug resistant bacteria using a phenolic compound.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: June 11, 2002
    Assignee: Colgate-Palmolive Company
    Inventors: John Brahms, Bruce Nascimbeni, Sukhvinder Sandhu
  • Patent number: 6376524
    Abstract: Triphenyl compounds of the formulae I, II, and VI: methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are compounds are interleukin-4 antagonists; and are useful for the treatment of asthma and allergies.
    Type: Grant
    Filed: June 21, 2000
    Date of Patent: April 23, 2002
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Kenneth J. Barr, Brian C. Cunningham, William Michael Flanagan, Wanli Lu, Brian C. Raimundo, Nathan D. Waal, Jennifer Wilkinson, Jiang Zhu, Wenjin Yang
  • Patent number: 6369115
    Abstract: A dry powder formulation for treatment of pulmonary conditions, via inhalation, includes an effective amount of formoterol or a salt or solvate thereof, in a dry powder form, an effective amount of fluticasone, in a dry powder form, and an excipient. A method for preparing a physically stable dry powder formulation for inhalation includes the steps of micronizing a first active polar drug, a second active non-polar drug, and a polar excipient. The second non-polar active drug is first blended with the excipient to form an intermediate mixture. The intermediate mixture is then blended with the first active polar drug. The increased separation of the polar drug and polar excipient stabilizes the formulation.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: April 9, 2002
    Assignee: Dura Pharmaceuticals, Inc.
    Inventor: Gary Ward
  • Patent number: 6331543
    Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: December 18, 2001
    Assignee: NitroMed, Inc.
    Inventors: David S. Garvey, Inigo Saenz de Tejada, Richard A. Earl, Subhash P. Khanapure
  • Patent number: 6300324
    Abstract: A composition (10) for repelling ticks and other insects contains a combination of plant extracts (14) in a topical liquid carrier (12). The plant extracts (14) include lavender (26), rosemary (30), thyme (32), aloe vera (28) and eucalyptus (34). The composition can further include one or more vitamins (18) such as Vitamin B1 (36), Vitamin B6 (38), Vitamin B12 (40) and Vitamin C (42). Lecithin (16) may be included as an additional insect repelling component and also to assist dispersion of the various active components in the liquid carrier (12).
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: October 9, 2001
    Inventor: Scott E. Partelow
  • Patent number: 6291533
    Abstract: Dietary supplement compositions designed to be responsive to specific blood types, and thus most beneficial for people with specific antigenic blood types.
    Type: Grant
    Filed: December 22, 1999
    Date of Patent: September 18, 2001
    Assignee: Vitamerica, Inc.
    Inventor: Albert M. Fleischner
  • Patent number: 6267948
    Abstract: A method and dermatological formulation are provided for increasing the pigmentation response of mammalian skin, hair, wool or fur to agents which stimulate melanogenesis. The method comprises administering to mammalian skin, hair, wool or fur a dermatological formulation containing a melanogenesis-stimulating effective amount of an agent which stimulates melanogenesis in melanocytes, and a melanogenesis-enhancing effective amount of an agent, such as an &agr;-hydroxy acid, which enhances the stimulation of melanogenesis by the melanogenesis-stimulation agent.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: July 31, 2001
    Assignee: Applied Genetics Incorporated Dermatics
    Inventors: Wu Yun Ren, Michael Seidman, David A. Brown
  • Patent number: 6217914
    Abstract: An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which has generally been pretreated by being dissolved under relatively high temperature and concentration conditions. The composition typically includes at least about 5.0% (w/v) ascorbic acid and may advantageously be formulated to have a pH above 3.5. Generally, the composition also includes non-toxic zinc salt, tyrosine compound, and/or pharmaceutically acceptable carrier. In addition, the composition may include an anti-inflammatory compound, such as aminosugar and/or sulfur-containing anti-inflammatory compound. The topical composition may be in the form of a serum, a hydrophilic lotion, an ointment, a cream, or a gel.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: April 17, 2001
    Assignee: Bioderm, Inc.
    Inventor: Lorraine Faxon Meisner
  • Patent number: 6214327
    Abstract: Lotion compositions for applying topically to skin include a barrier-forming polymer mixture and an anti-microbial agent. The polymer dries on skin to form a barrier which prevents pathogens, solvents and petrochemicals from penetrating into the skin. The barrier is resistant to being washed off for at least several hours, during which time the antibacterial agent effectively kills a broad spectrum of bacteria within seconds after contact.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: April 10, 2001
    Assignee: Bio-Safe Enterprises, Inc.
    Inventors: Howard N. Steward, Lee L. Paler, John A. Garruto
  • Patent number: 6160024
    Abstract: Disclosed herein are compounds, compositions, and methods to inactivate a virus and destroy tumor cells. The methods involve the addition into the cell of a compound containing a photosensitizing chemical and an energy donating chemical, optionally linked by a chemical tether. Also introduced into the cell are means to chemically activate the energy donating chemical which photoactivates the photosensitizing chemical which then destroys the tumor or virus. The photosensitizing chemical is preferably hypericin, porphyrin, or an analog and the energy donating chemical is preferably luciferin or an analog. Methods for synthesizing the chemicals are also disclosed. Further, the energy donating chemical is activated by an activating chemical. The expression of the activating chemical is regulated so as to target the virus-infected or tumor cells.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: December 12, 2000
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: George A. Kraus, Susan L. Carpenter, Jacob W. Petrich
  • Patent number: 6159999
    Abstract: An antimicrobial composition is provided in which the skin irritation of isothiazolone type compound is decreased and the injection operation properties thereof is improved by forming it as an uniform solution. The composition contains isothiazolone type compound and a compound which decreases the skin irritation of the former in a molar ratio of 1:0.1-50 and is dissolved in a solvent.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: December 12, 2000
    Assignee: Kurita Water Industries Ltd.
    Inventors: Minoru Yagi, Tetsuya Aoki
  • Patent number: 6139879
    Abstract: The present invention relates to heavy metal chelate compositions, which are used as fungicides and bactericides, and methods of using the compositions. In particular, the present invention relates to a chelate, that is an EDDHA (copper-ethylenediamine-di-o-hydroxyphenylacetic acid), combined with a heavy metal, including iron, tin, zinc, manganese, copper, and combinations thereof.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: October 31, 2000
    Assignee: Foliar Nutrients, Inc.
    Inventor: John B. Taylor
  • Patent number: 6103768
    Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: August 15, 2000
    Assignee: Mycogen Corporation
    Inventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
  • Patent number: 6103753
    Abstract: An intimal thickening inhibitory agent comprising, as an active ingredient, a compound represented by formula (1): ##STR1## wherein X represents an oxygen atom or a group of formula (2): ##STR2## wherein n represents an integer of from 0 to 2, R.sub.1 represents a hydrogen atom or an acyl group; R.sub.2 represents a hydrogen atom, a lower alkyl group or a lower alkenyl group; R.sub.3 represents a lower alkyl group; and R.sub.4, R.sub.5, and R.sub.6, which may be the same or different, each represent a hydrogen atom or a substituted or unsubstituted alkyl group; or R.sub.3 and R.sub.4 may be taken together to form a 5-membered ring; or R.sub.5 and R.sub.6 may be taken together to form a cycloalkyl group; provided that R.sub.6 is nil when R.sub.3 and R.sub.4 are taken together to form benzofuran or benzo[b]thiophene.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: August 15, 2000
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Osamu Cynshi, Reiko Sekimori, Yoshiaki Kato
  • Patent number: 6087391
    Abstract: Organic compounds containing at least one hydrophilic group are rendered soluble in fatty systems by the formation of a chemical complex with a carrier selected among fatty acid esters of polyhydric hydroxyalkanes having general formula (I) ##STR1## wherein R.sub.1 is H or --CH.sub.2 OR.sub.5, R.sub.2 is H or --CH.sub.2 OR.sub.6, and each of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is independently a saturated or unsaturated fatty acid moiety having 1-30 carbon atoms or a saturated fatty acid moiety having 1-3 carbon atoms, with the proviso that at least one of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is a saturated or unsaturated fatty acid moiety having 1-30 carbon atoms, R2 and at least one or, when any of R.sub.1 and R.sub.2 is not H, at least two of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is a saturated fatty acid moiety having 1-3 carbon atoms. Diacetates of common monoglycerides are especilally preferred as the carriers for forming such complexes.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: July 11, 2000
    Inventor: Morten Sloth Weidner
  • Patent number: 6080791
    Abstract: A method of preventing and treating a viral condition caused by an enveloped virus is described, comprising using a therapeutically effective amount of a compound selected from the group consisting of a substituted hydroquinone and the corresponding benzoquinone, wherein said hydroquinone comprises a 2-R.sup.1, 3-R.sup.2 -1,4-hydroquinone where at least one of R.sup.1 and R.sup.2 include a carbon linkage to the benzene ring of the hydroquinone. Particularly useful compounds include 5,8-dihydro-5,8-methano-1,4-naphthalenediol, 1,4-naphthoquinone, 3', 6'-dihydroxybenzo-norbornane, tert-butylhydroquinone, other diols, e.g. 1,5-naphthalenediol, and alkylated diols, e.g. 4-methoxy-1-naphthol.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: June 27, 2000
    Assignees: Seres Laboratories, Inc., University of California
    Inventors: Dale L. Bodian, Judith M. White, Irwin D. Kuntz, Jay F. Stearns, R. Bryan Yamasaki
  • Patent number: 6060311
    Abstract: The invention provides a method of suppressing ventricular muscle cell hypertrophy induced by an .alpha..sub.1 -adrenergic agonist or endothelin, by providing an effective amount of a retinoic acid compound.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: May 9, 2000
    Assignee: The Regents of the University of California
    Inventors: Kenneth R. Chien, Ming Dong Zhou
  • Patent number: 6015836
    Abstract: A new and improved formulation of a dual chain quaternary ammonium chloride compound and iodine/potassium iodide complex to serve as a disinfectant and sanitizer on surfaces and tissue as well as being utilized as an immersion solution in health care areas. The dual-quat with iodine formulation of the present invention is more useful over a wide range of areas and uses and is also more stable over a wide variety of water combinations. It improves efficacy, reduces toxicity, increases the spectrum of the antimicrobial effectiveness and broadens the effective usage of the complex into new areas of application.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: January 18, 2000
    Inventor: Howard Martin
  • Patent number: 5998485
    Abstract: A composition for modulating immune response in mammals, comprises a therapeutic agent such as a stereoisomer of inositol, derivatives, salts, and mixtures thereof, and optionally a carrier. The composition is provided in solid and liquid formulations, including solutions, suspensions, spreadable and solid forms, as an implant, inhalant, and in vaporizable, injectable, oral and transdermal forms, and the like. The composition of the invention is useful for modulating (enhancing/inhibiting) the immune response. The therapeutic agent of this invention enhances/suppresses B and/or T lymphocyte activity(ies) in normal, aging and immunodeficient mammals, as well as those afflicted with auto-immune disease (s), or subjected to transplants.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: December 7, 1999
    Assignee: Cedars-Sinai Medical Center
    Inventors: Marvin L. Tyan, Dolly B. Tyan
  • Patent number: 5989583
    Abstract: Lipophilic substances of poor oral bioavailability are mixed with at least one solid fat and phospholipid to obtain a dried solid composition suitable as an oral dosage form. The solid lipid compositions are exemplified for food additives or dietary supplements such as Coenzyme Q10 and for pharmaceuticals such as dexanabinol. The Coenzyme Q10-dry lipid mixtures shows improved drug release in vitro and enhanced oral bioavailability in vivo compared to a commercial CoQ10 formulation. The dexanabinol-dry lipid mixture similarly shows greatly enhanced oral bioavailability compared to known formulations.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: November 23, 1999
    Assignee: Pharmos Ltd.
    Inventor: Shimon Amselem
  • Patent number: 5922313
    Abstract: Lotion compositions for applying topically to skin include a barrier-forming polymer mixture and an anti-microbial agent. The polymer dries on skin to form a barrier which prevents pathogens, solvents and petrochemicals from penetrating into the skin. The barrier is resistant to being washed off for at least several hours, during which time the antibacterial agent effectively kills a broad spectrum of bacteria within seconds after contact.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: July 13, 1999
    Assignee: Bio-Safe Enterprises, Inc.
    Inventors: Howard N. Steward, Lee L. Paler, John A. Garruto
  • Patent number: 5880146
    Abstract: Disclosed are chemical agents for modulating certain cellular immune reactions that can lead to autoimmune disorders. By specific modulation, harmful immune reactions can be lessened in severity or even prevented without resorting to potentially dangerous general immune suppression. The described chemical agents inhibit IL-12 induction of the secretion of key immune modulators. The described chemical agents are specific inhibitors of IL-12 induced Th1 immune response.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 9, 1999
    Assignee: Fuji ImmunoPharmaceuticals Corporation
    Inventors: Stephen D. Gillies, John Wesolowski
  • Patent number: 5753270
    Abstract: A preparation which is compatible with the skin for the treatment of labial disease and acne. The preparation comprises a mixture of:(a) at least one compound selected from an antiseptic compound and an anesthetic compound which is:(i) a terpene,(ii) a phenolic compound, or(iii) an alcohol;(b) a quaternary ammonium antiseptic compound;(c) an antiseptic compound selected from compounds containing iodine, salts thereof and complexes thereof dissolved in an organic skin penetrating solvent, wherein said solvent comprises acetone.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: May 19, 1998
    Assignees: Patrick A. Beauchamp, James A. Rogers
    Inventors: Patrick A. Beauchamp, James A. Rogers
  • Patent number: 5739171
    Abstract: Methods for promoting animal growth comprising administering one or more substances selected from o-nitrophenol, p-nitrophenol, 5-nitroguaiacol and salts thereof as active ingredients.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: April 14, 1998
    Assignee: Asahi Chemical Manufacturing Co., Ltd.
    Inventors: Gisen Shimazaki, Chen Jian Jun, Norio Ohara