C Of C-o- Group Is Nuclear C Of A Benzene Ring (e.g., Phenol, Phenolate, Etc.) Patents (Class 514/728)
  • Patent number: 5677336
    Abstract: Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and for treating patients requiring androgen receptor antagonist therapy.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: October 14, 1997
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Todd K. Jones, Lawrence G. Hamann, Luc Farmer, Michael G. Johnson, Mark E. Goldman
  • Patent number: 5639472
    Abstract: A percutaneous absorption preparation comprising a support and, formed on one side thereof, a plaster layer comprising a pressure-sensitive adhesive and tulobuterol in an amount not lower than its saturation solubility in the pressure-sensitive adhesive, the tulobuterol contained in the plaster layer consisting of dissolved tulobuterol and crystalline tulobuterol with the ratio of the content of the crystalline tulobuterol to that of the dissolved tulobuterol being from 0.1 to 10.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: June 17, 1997
    Assignees: Nitto Denko Corporation, Hokuriku Seiyaku Co., Ltd.
    Inventors: Keiji Yamamoto, Yoshihisa Nakano, Saburo Otsuka
  • Patent number: 5622709
    Abstract: A parenteral dosage form for cimetidine is provided. The dosage form contains less phenol than conventional formulations.
    Type: Grant
    Filed: July 17, 1995
    Date of Patent: April 22, 1997
    Assignee: SmithKline Beecham Corporation
    Inventor: Margaret M. Szymczak
  • Patent number: 5538959
    Abstract: A magnesium-containing analgesic composition used for treating migraine headaches and methods for using the same are described herein. The composition comprises an analgesic, a magnesium salt and an effervescing agent and is admixed with or dissolved in water prior to ingestion. The symptoms of migraine headache intended to be alleviated include nausea, unilateral pain, dizziness, pulsatile pain, worsening of pain by light physical activity, photophobia and phonophobia.
    Type: Grant
    Filed: January 26, 1995
    Date of Patent: July 23, 1996
    Inventor: Alexander Mauskop
  • Patent number: 5514667
    Abstract: A method for the topical treatment of herpes virus infections of the skin and mucous membranes is disclosed- This method uses a topical preparation comprising an anti-vital drug in combination with a potentiating drug which is an anti-inflammatory or an anti-oxidant drug. A preferred preparation includes zinc pentosan polysulphate in combination with bufexamac.
    Type: Grant
    Filed: July 28, 1995
    Date of Patent: May 7, 1996
    Assignee: Arthropharm Pty. Limited
    Inventor: David Cullis-Hill
  • Patent number: 5393776
    Abstract: This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for atherosclerosis. Also provided are pharmaceutical compositions and a method of use employing those compositions.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: February 28, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventor: Bradley C. Pearce
  • Patent number: 5385942
    Abstract: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: January 31, 1995
    Assignee: Eisai Co., Ltd.
    Inventors: Shinya Abe, Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Junichi Nagakawa, Kazuo Hirota, Ieharu Hishinuma, Kaname Miyamoto, Takashi Yamanaka, Hiromitsu Yokohama, Tsutomu Yoshimura, Tohru Horie, Yasunori Akita, Koichi Katayama, Isao Yamatsu
  • Patent number: 5322689
    Abstract: The present invention relates to topical aromatic releasing compositions substantially free from petrolatum and containing one or more volatile aromatic compounds selected from the group consisting of menthol, camphor and eucalyptus oil and mixtures thereof. In further embodiments, these compositions contain one or more topical actives, and are also useful for providing relief from symptoms associated with respiratory disorders.
    Type: Grant
    Filed: March 10, 1992
    Date of Patent: June 21, 1994
    Assignee: The Procter & Gamble Company
    Inventors: Timothy J. Hughes, George E. Deckner
  • Patent number: 5284875
    Abstract: A fortified quaternary ammonium compound with and without dual synergistic phenols is provided for disinfection and sanitization. One formula consists of dual chain quaternary ammonium chloride (N-alkyl dimethylethylbenzyl ammonium chloride and N-alkyl dimethylbenzyl ammonium chloride), ortho phenyl phenol, para tertiary amyl phenol, citric or acetic acid, sodium citrate, isopropyl or ethyl alcohol, triethanol amine-HCl and water in the following proportions 50.00 to 0.50 grams, 1.00 to 0.08 grams, 1.00 to 0.08 grams, 0.50 to 0.05 grams, 0.25 to 0.025 grams, 14.00 to 1.40 grams, 5.00 to 1.00 grams, 28.25 to 96.865 grams. The formula for environmentally protected uses consists of dual chain quaternary ammonium chloride (N-alkyl dimethylethylbenzyl ammonium chloride and N-alkyl dimethylbenzyl ammonium chloride), citric or acetic acid, sodium citrate, isopropyl or ethyl alcohol, triethanol amine-HCl and water in the following proportions: 50.00 to 0.50 grams, 0.50 to 0.05 grams, 0.25 to 0.025 grams, 14.00 to 1.
    Type: Grant
    Filed: April 16, 1993
    Date of Patent: February 8, 1994
    Inventor: Howard Martin
  • Patent number: 5250573
    Abstract: A sterilising composition of antibacterial and antimycotic activity possessing considerable stability with time, comprising glutaraldehyde, an alkyl-, aryl- or halogen-substituted phenol, a non-ionic surface-active agent and preferably an alkanol of 2-5 carbon atoms, in an aqueous vehicle, at a pH of between 3.5 and 5.5.
    Type: Grant
    Filed: November 9, 1988
    Date of Patent: October 5, 1993
    Assignee: Germo S.p.A.
    Inventor: Luigi F. Magni
  • Patent number: 5232914
    Abstract: A solid, storage-stable, germicidal, pre-iodine composition comprises in dry admixture with each other a solid oxy-compound of iodine, a solid reducing agent for the oxy-compound of iodine, and a solid desiccant used in amount sufficient to combine during the storage cycle of the composition with ambient and/or endogenous water. The oxy-compounds of iodine are iodic acid, iodine pentoxide, potassium iodate and sodium iodate. Preferred reducing agents are ascorbic acid, dihydroxy fumaric acid, the thiol sugars and cysteine. A preferred combination desiccant and iodine solvating agent is polyvinyl pyrrollidone having a molecular weight of from 10,000 to 1,000,000.The composition is storage-stable for an indefinite period. Upon the addition of water, the oxy-compound of iodine is reduced to nascent iodine, which, in application, serves its well-known germicidal function.
    Type: Grant
    Filed: March 29, 1991
    Date of Patent: August 3, 1993
    Assignee: Epitope, Inc.
    Inventor: Jack H. Fellman
  • Patent number: 5216032
    Abstract: A method of treating a subject in cardiac arrest, comprises blocking the descending aorta of the subject and then perfusing the aortic arch of the subject with a protective solution. The protective solution is one capable of delivering oxygen to the heart of said subject, such as a perfluorochemical blood substitute. Following perfusion, spontaneous circulation is restored.In an improved embodiment of the foregoing, a vasoconstrictor such as epinephrine is administered concurrently with the perfusing step in an amount effective to enhance coronary perfusion with said protective solution.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: June 1, 1993
    Assignee: The University of North Carolina at Chapel Hill
    Inventor: James E. Manning
  • Patent number: 4935450
    Abstract: A method for effecting oncolysis, regression, and control of malignant neoplasms in humans and other mammals without adverse effects on normal body cells is described. An ATP-availability depressor may be combined with a defined nutritional regimen, a fatty acid blocker, an amino acid blocker, a lactate export blocker, or any combination thereof.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: June 19, 1990
    Assignee: Therapeutical Systems Corporation
    Inventor: Clarence D. Cone, Jr.
  • Patent number: 4724234
    Abstract: A method of producing oncolysis and regression of malignant tumors and other malignant conditions without adverse effects on normal body cells is described. A calorically and compositionally defined nutritional regimen providing a minimum of amino acids and fatty acids and a maximum of carbohydrates is administered concurrently with a drug regimen of an agent or agents that uncouple oxidative phosphorylation, most preferably 2,4-dinitrophenol.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: February 9, 1988
    Assignee: Therapeutical Systems Corp.
    Inventor: Clarence D. Cone, Jr.
  • Patent number: 4724230
    Abstract: An improved method is described for producing oncolysis, including regression of malignant tumors or other malignant conditions, without adverse effects upon normal body cells. In addition to a calorically and compositionally defined nutritional regimen providing a minimum of amino acids and fatty acids and a maximum of carbohydrate, administered concurrently with a drug regimen of an agent or agents that uncouple oxidative phosphorylation (most preferably 2,4-dinitrophenol), there is also concurrently administered a selected amount of a substantially non-toxic fatty acid oxidation inhibitor capable of effectively lowering the mitochondrial .beta.-oxidation rate of fatty acids.
    Type: Grant
    Filed: July 25, 1984
    Date of Patent: February 9, 1988
    Assignee: Therapeutical Systems Corp.
    Inventor: Clarence D. Cone, Jr.
  • Patent number: 4692261
    Abstract: A synthetic detergent bar is provided containing hydroquinone as a skin bleaching agent. The bar is maintained at a pH of between about 4 and 7 and includes a compressed mixture of a synthetic anionic detergent such as sodium cocoyl isethionate, sodium lauryl sulfoacetate and sodium methyl cocoyl tourate; hydroquinone, a stabilizer for said hydroquinone such as tertiary butyl hydroquinone, water, a buffer which maintains the pH of the bar at about 4 to about 7 and excipients such as waxes, paraffin, dextrin and starches. Because of the maintenance of low pH and the presence of a stabilizer, hydroquinone is not oxidized and thus the bar is characterized by an extended shelf life.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: September 8, 1987
    Assignee: Warner-Lambert Company
    Inventor: Vito G. Filomeno