Alicyclic Ring Containing Patents (Class 514/729)
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Publication number: 20140242138Abstract: Method for the preparation of microencapsulated essential oils or a formulation thereof for various non-agricultural applications.Type: ApplicationFiled: May 7, 2014Publication date: August 28, 2014Applicant: BOTANOCAP LTD.Inventors: Amnon Kritzman, Arie Markus, Pnina Strongin, Charles Linder
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Publication number: 20140234225Abstract: The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.Type: ApplicationFiled: February 17, 2014Publication date: August 21, 2014Applicant: Alkermes Pharma Ireland LimitedInventors: Christian F. Wertz, Niels P. Ryde
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Patent number: 8809398Abstract: The present invention relates to a liquid formulation containing at least one carotenoid, at least one hydrophilic protective colloid and at least one water-miscible alcohol. The formulation according to the invention can be added directly to aqueous or non-aqueous preparations. The invention compositions can be used in animal feed, human food or a dietary supplement and in pharmaceutical and cosmetic preparations.Type: GrantFiled: January 15, 2008Date of Patent: August 19, 2014Assignee: BASF SEInventors: Christian Köpsel, Jesper Feldthusen Jensen
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Patent number: 8809391Abstract: The present invention relates to the use of 3-methyl-6-(1-methylethenyl)cyclohex-3-ene-1,2-diol, its isomers and derivatives, as a compound for Parkinson disease treatment, that can be used in medicine. The compound is highly active, low toxic and can be synthesized from available natural compound ?-pinene. 13 ex., 7 tables.Type: GrantFiled: December 23, 2010Date of Patent: August 19, 2014Assignee: OOO “Tomskaya Farmatsevticheskaya Fabrika”Inventors: Nariman Faridovich Salahutdinov, Tatiana Genrihovna Tolstikova, Alla Viktorovna Pavlova, Ekaterina Aleksandrovna Morozova, Irina Viktorovna Il'ina, Oleg Vasil'evich Ardashov, Konstantin Petrovich Volcho
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Publication number: 20140227242Abstract: Provided are compositions and methods for producing stable foods and beverages that contain high concentrations of additives such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols and carotenoids; oil soluble vitamins; alpha lipoic acid; other oils; and coenzymes, including Coenzyme Q10, and other oil-based additives.Type: ApplicationFiled: April 15, 2014Publication date: August 14, 2014Inventors: Philip J. Bromley, Chetan S. Rao
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Publication number: 20140227214Abstract: A carotenoid substance called zeaxanthin, when ingested orally at suitable dosages such as 30 to 100 mg/day for a span of 1 to 2 weeks, can provide effective protection against sunburns, and can give skin a darker tint that emulates a healthy suntan. In tests involving adults, it was found that zeaxanthin dosages of 30 to about 80 mg per day were sufficient to induce: (i) a mild but noticeable tinting, shading, or darkening of skin color, comparable to a mild suntan; (ii) a substantial increase in the person's ability to withstand elevated levels of sun or UV exposure without any subsequent pain or discomfort, and without the subsequent peeling and flaking that characterizes sunburns; and, (iii) an increased ability of reddened and sunburned skin to convert into intact skin that looks browned and healthily tanned.Type: ApplicationFiled: April 22, 2014Publication date: August 14, 2014Applicant: ZeaVision, LLCInventors: Dennis L. Gierhart, Joseph A. Fox
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Publication number: 20140219931Abstract: The present invention relates to a p-menthane-3,8-diol isomer mixture 50% by mass or more of which is constituted of (1S)-isomers and a cooling sensation composition containing this mixture. The present invention also relates to a flavor and/or fragrance composition, food, beverage, cosmetic, daily use product, oral cavity composition, or pharmaceutical containing the p-menthane-3,8-diol isomer mixture in an amount of 0.0001 to 90% by mass.Type: ApplicationFiled: August 31, 2012Publication date: August 7, 2014Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Yasuhiro Komatsuki, Shigeru Tanaka, Kenya Ishida
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Publication number: 20140221487Abstract: In one embodiment, the invention provides a method of enhancing a subject's macular pigment optical density, the method comprising administering to the subject a pharmaceutically effective amount of one or more Xanthophyll carotenoids. Preferably, the Xanthophyll carotenoids are selected from the group consisting of lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ), and enantiomers, metabolites, esters, pharmaceutically acceptable salts and derivatives thereof. In certain embodiments, the Xanthophyll carotenoids such as lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) are each in substantially pure enantiomeric form.Type: ApplicationFiled: April 30, 2012Publication date: August 7, 2014Applicant: University of Georgia Research Foundation, IncInventors: Lisa M. Renzi, Billy R. Hammond
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Publication number: 20140212507Abstract: Disclosed is a method for determining a supplement regime for a subject diagnosed with age-related macular degeneration (AMD). The method involves determining the subject's risk of developing advanced AMD based on their genetic profile for the complement factor H gene and the ARMS2 gene and administering a supplement containing antioxidants and/or zinc based on their risk of developing advanced AMD.Type: ApplicationFiled: July 31, 2013Publication date: July 31, 2014Applicant: ArcticDx Inc.Inventors: Brent Zanke, Carl Awh
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Publication number: 20140199396Abstract: Process for the manufacture of a powder containing lutein, powder obtainable by said process and food composition containing said powder.Type: ApplicationFiled: March 28, 2012Publication date: July 17, 2014Applicant: DSM IP ASSETS B.V.Inventors: Christian Schaefer, Bernd Schlegel
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Publication number: 20140187647Abstract: Systems and methods may be provided for improving the visual performance of a human subject without the need to test the macular pigment concentration in the eye or eyes of the subject. The method may include identifying a subject likely to have an atypical ‘central dip’ macular pigment distribution; and administering an amount of a macular pigment-containing composition sufficient to improve the visual performance of the subject. Identifying a human subject, more likely than a subject selected at random from the general population, to have an atypical ‘central’ dip macular pigment distribution may include measuring at least one cognitive function of the subject; comparing the measured cognitive function with a pre-determined threshold; and, if the measured cognitive function is below the threshold, declaring the subject as being more likely to have an atypical ‘central dip’ macular pigment profile.Type: ApplicationFiled: January 29, 2013Publication date: July 3, 2014Applicant: HOWARD FOUNDATION HOLDINGS LTD.Inventors: Alan N. Howard, John Nolan, Stephen Beatty
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Publication number: 20140187648Abstract: A method of identifying a human subject, more likely than a subject selected at random from the general population, to have one or more of the following: (i) a low macular pigment concentration in the eye or eyes; (ii) a low visual performance, or (iii) an atypical “central dip” macular pigment distribution; the method comprising the steps of: measuring at least one cognitive function of the subject; comparing the measured cognitive function with a pre-determined threshold; and, if the measured cognitive function is below the threshold, declaring the subject as being more likely to have one or more of low macular pigment concentration in the eye or eyes, low visual performance or an atypical ‘central dip’ macular pigment profile.Type: ApplicationFiled: January 2, 2014Publication date: July 3, 2014Applicant: HOWARD FOUNDATION HOLDINGS LTD.Inventors: Alan N. Howard, John Nolan, Stephen Beatty
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Publication number: 20140170222Abstract: The present invention encompasses a carotenoid composition, a process for producing a carotenoid composition, and methods of use thereof.Type: ApplicationFiled: December 13, 2013Publication date: June 19, 2014Applicant: Novus International Inc.Inventors: Gary Reznik, Joan Carles Ferrater Martorell, David Ribera, Antonio Viso, Juan Antonio Fernandez, Delfin Ferrus, Scott Hine
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Publication number: 20140171498Abstract: This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from Leucas stelligera, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same.Type: ApplicationFiled: August 6, 2012Publication date: June 19, 2014Applicant: Council of Scientific & Indusrtial ReasearchInventors: Swati Joshi, Roshan Rajan Kulkarni, Ketaki Dilip Shurpali, Sampa Sarkar, Dhiman Sarkar
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Patent number: 8748496Abstract: The present disclosure relates to compositions and methods for reducing uric acid levels in a individual in need thereof. The present disclosure further relates to the treatment of hyperuricemia and diseases associated with high uric acid levels in mammals using scyllo-inositol.Type: GrantFiled: September 15, 2009Date of Patent: June 10, 2014Assignee: Elan Pharmaceuticals, Inc.Inventor: Jesse M. Cedarbaum
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Patent number: 8734838Abstract: A pressure-sensitive adhesive composition which comprises three ingredients, i.e., polyisoprene, a styrene/isoprene/styrene copolymer, and solid polyisobutylene, in a proportion of (10-60)/(10-50)/(20-60) by weight and further contains a non-solid isobutylene polymer and a tackifier, characterized in that the amount of the non-solid isobutylene polymer is 1 to 30 pts. wt., excluding 30 pts. wt., per 100 pts. wt. of the sum of the three ingredients, i.e., the polyisoprene, styrene/isoprene/styrene copolymer, and solid polyisobutylene. When used in an adhesive patch for external use on the skin, the composition has satisfactory tackiness regardless of whether the temperature of the surrounding air is high or low, has excellent long-term storage stability, retains the necessary cohesive force, and does not unnecessarily irritate the skin.Type: GrantFiled: October 20, 2004Date of Patent: May 27, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Masato Shirai, Takaaki Yoshinaga, Masato Wakamatsu
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Patent number: 8729033Abstract: This invention regards the use of zeaxanthin and/or rutin, as such or further combined with spermidine, as the active principle in a pharmaceutical, dietary, or cosmetic composition, acting to inhibit caspase-3 and therefore to control apoptosis by preventing programmed cell death. The indication for this composition according to the invention is primarily the treatment of scalp disorders characterized by excessive cellular turnover including chemotherapy-induced alopecia, alopecia areata, androgenetic alopecia and telogen effluvium.Type: GrantFiled: October 30, 2009Date of Patent: May 20, 2014Assignee: Giuliani S.p.A.Inventors: Giammaria Giuliani, Anna Benedusi, Sergio Baroni
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Publication number: 20140135404Abstract: Bicyclic sesquiterpene compounds exhibiting antifungal characteristics are formulated into antifungal compositions for use in the treatment of fungal infections in humans, animals, and plants. Particularly, sesquiterpene alcohols derived from drimane have been discovered to possess broad-spectrum antifungal characteristics. Exemplary antifungal sesquiterpene compounds include albicanol and drimenol, which have been shown effective against a number of pathogenic fungi.Type: ApplicationFiled: January 21, 2014Publication date: May 15, 2014Applicant: Kansas State University Research FoundationInventors: Govindsamy Vediyappan, Duy H. Hua
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Publication number: 20140135403Abstract: The present invention relates to methods of treating ocular diseases in a subject by administering to the subject a therapeutically effective amount of one or more cyclohexanehexyl derivatives, or salts thereof, or a medicament comprising a cyclohexanehexol derivative and a pharmaceutically acceptable carrier. More specifically, the invention provides a medicament comprising at least one cyclohexanehexyl derivative of formula (III) or (IV) useful in preventing or treating ocular diseases, by modulating the folding, oligomerization or aggregation of amyloid ? in ocular cells. Methods of administration of these medicaments include systemic, transpleural, oral, intravenously, intraarterial, intramuscular, topical, via inhalation, transdermal, subcutaneous, intraperitoneal, gastrointestinal, and directly to the eye or tissues surrounding the eyes. Formulae (III), (IV).Type: ApplicationFiled: January 16, 2014Publication date: May 15, 2014Applicant: WARATAH PHARMACEUTICALS INC.Inventors: JoAnne McLAURIN, Antonio CRUZ
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Publication number: 20140135374Abstract: Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.Type: ApplicationFiled: June 13, 2012Publication date: May 15, 2014Applicant: BIKAM PHARMACEUTICALS, INC.Inventor: David S. Garvey
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Patent number: 8703829Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.Type: GrantFiled: May 23, 2012Date of Patent: April 22, 2014Assignee: University of Louisville Research Foundation, Inc.Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
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Publication number: 20140099386Abstract: Micro-micelle forms of carotenoids and/or xanthophylls, which show improved absorption and biovailability by living organisms, provide higher levels of carotenoids in the blood stream, and consequently are deposited at the target tissues at a faster rate and more efficiently than crystalline carotenoids are provided. The micro-micelle forms do not contain any crystal forms of carotenoids, and are obtained as micro-micelles after melting Lutein diacetate or Lutein dipropionate in their natural original lipid vegetable matrix, in the presence of lipids, phospholipids, fatty acids, emulsifiers and moisture. The micro-micelle forms can be ingested at a dosage between 2 mg to 50 mg to provide an absorption of the carotenoid solubilizate that is at least 20% above that of crystalline carotenoids, and provides a macular pigment deposit that exceeds at least 10% of Macular Pigment Optical Density, than the deposition obtained by ingesting crystalline Lutein.Type: ApplicationFiled: December 9, 2013Publication date: April 10, 2014Applicant: INDUSTRIAL ORGÁNICA, S.A. DE C.V.Inventors: Ricardo Montoya-Olvera, Jose-Odon Torres-Quiroga
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Publication number: 20140086857Abstract: Compositions comprising siloxane polymers are disclosed. The compositions are useful as thixotropic bases for a variety of components, such as antimicrobial agents, sterilants, medicaments, antibiotics, analgesics, essential oils, preservatives, colorants, fragrances, and the like. Methods for preparing the compositions are also disclosed.Type: ApplicationFiled: May 10, 2012Publication date: March 27, 2014Applicant: QUADSIL, INC.Inventor: John D. Blizzard
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Publication number: 20140080919Abstract: Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial products and in particular handcare or skincare products.Type: ApplicationFiled: November 20, 2013Publication date: March 20, 2014Applicant: ECOLAB USA INC.Inventors: Joseph R. Wegner, Cheryl A. Littau
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Publication number: 20140073701Abstract: Disclosed are methods of preventing, treating, or diagnosing in a subject a disorder in protein folding or aggregation, or amyloid formation, deposition, accumulation, or persistence consisting of administering to said subject a pharmaceutically effective amount of inositol stereoisomers, enantiomers or derivatives thereof.Type: ApplicationFiled: September 3, 2013Publication date: March 13, 2014Inventor: Joanne McLaurin
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Publication number: 20140073702Abstract: Methods for the prevention, treatment and/or alleviation of skin disorders and skin cancers, and for the prevention, treatment and/or alleviation of prostate cancer and pancreatic cancer by administering a Lupeol-derived anti-tumor compound are disclosed. Pharmaceutical and nutraceutical compositions containing Lupeol-derived anti-tumor compounds are also disclosed.Type: ApplicationFiled: November 15, 2013Publication date: March 13, 2014Applicant: Wisconsin Alumni Research FoundationInventors: Hasan Mukhtar, Mohammad Saleem Bhat
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Patent number: 8664224Abstract: External preparations for athlete's foot treatment capable of enhancing patient's compliance and capable of reducing the symptom of rubefaction, comprising an anti-trichophyton drug mixed with at least one compound selected from among 1-menthol, menthol analogue compounds and bactericidal compounds.Type: GrantFiled: July 15, 2011Date of Patent: March 4, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Toshihiro Shirouzu, Youichi Kawamura, Hiroki Kawatsura, Mitsuhiko Tokunaga
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Publication number: 20140056965Abstract: A removable patch configured to be applied over a skin surface, comprises an adhesive layer disposed on the removable patch, and a delivery layer disposed on the removable patch. The delivery layer carries an activating chemical neuromodulator adapted to be transcutaneously applied to afferent A fibers disposed under the skin surface. The delivery layer further carries an inhibiting chemical neuromodulator adapted to be transcutaneously applied to C fibers disposed under the skin surface. A method for treating a patient suffering from a neurological disorder comprises transcutaneously applying an activating chemical neuromodulator over a skin surface adjacent to a trigeminal nerve tissue of the patient, and activating afferent A fibers in the trigeminal nerve, the activation being carried out by the chemical neuromodulator.Type: ApplicationFiled: August 19, 2013Publication date: February 27, 2014Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATIONInventor: Kerry Bradley
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Publication number: 20140056995Abstract: Novel Uses of small molecules, particularly, triterpenoids and ingol diterpenes isolated from Euphorbia neriifolia, are disclosed herein. The triterpenoids are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer; whereas the ingol diterpenes are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating thrombocytopenia.Type: ApplicationFiled: August 27, 2012Publication date: February 27, 2014Applicant: Mackay Memorial HospitalInventors: YU-JEN CHEN, Lie-Chwn Lin, Ching-Pin Lin
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Patent number: 8652464Abstract: The present invention is directed to nanoparticulate active agent compositions comprising lysozyme as a surface stabilizer. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate active agent composition of the invention and methods of making and using such nanoparticulate and pharmaceutical compositions.Type: GrantFiled: December 4, 2012Date of Patent: February 18, 2014Assignee: Alkermes Pharma Ireland LimitedInventors: Christian F. Wertz, Niels P. Ryde
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Publication number: 20140031434Abstract: The present invention relates to a use of patchouli alcohol in the preparation of a drug against Helicobacter pylori. The drug according to the present invention is composed of the patchouli alcohol and pharmaceutically acceptable additives, wherein the content of the patchouli alcohol is 0.5-70%. The patchouli alcohol according to the present invention has a quite narrow antimicrobial spectrum, and may selectively inhibit Helicobacter pylori without influencing growth and propagation of other bacterial populations (including other gram negative bacteria). The patchouli alcohol may kill Helicobacter pylori without damaging probiotics, and may keep an ecological balance of bacterial populations in the intestinal tract of human body. Therefore, the patchouli alcohol may be used for treatment of diseases caused by infection of Helicobacter pylori, such as gastritis, peptic ulcer and early gastric cancer.Type: ApplicationFiled: October 22, 2011Publication date: January 30, 2014Applicant: Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of ChineseInventors: Xiaoping Lai, Ziren Su, Jiannan Chen, Yucui Li, Jingjin He
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Publication number: 20140024657Abstract: The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-?) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I)-(VIII) and by Compounds (1)-(7), (13)-(26), (27)-(33), (48)-(57), and (58)-(70). These necrostatins are shown to inhibit TNF-? induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring necrostatins. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.Type: ApplicationFiled: September 20, 2013Publication date: January 23, 2014Applicant: President and Fellows of Harvard CollegeInventors: Junying YUAN, Emily S. Hsu
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Patent number: 8633252Abstract: This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity.Type: GrantFiled: January 26, 2010Date of Patent: January 21, 2014Assignees: Taipei Medical University, National Taiwan University, National Tsing Hua University, DCB-USA LLCInventors: Feng-Lin Hsu, Shing-Hwa Liu, Biing-Jiun Uang
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Publication number: 20140017324Abstract: An L-menthol-containing multiparticulate formulation includes a plurality of individual enteric coated cores containing L-menthol from an at least 80% pure L-menthol source. The enteric coated cores are effective to release at least about 35% of the L-menthol within about two hours, and at least about 80% of the L-menthol within about eight hours after being placed in an environment having a pH of 5 to 8. The L-menthol multiparticulate formulation can be used to treat gastrointestinal disorders.Type: ApplicationFiled: September 23, 2013Publication date: January 16, 2014Applicant: ZX PHARMA, LLCInventors: SYED SHAH, FRED HASSAN, DANIEL HASSAN, SARAH HASSAN
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Publication number: 20140018328Abstract: The present invention relates to compositions including anhydrous compositions which include a dimethicone crosspolymer and/or dimethicone elastomer gum and one or more skin care products which may include retinoic acid, retinoic acid derivatives, retinal, retinol and/or retinyl esters, and methods of making, storing, and using such compositions.Type: ApplicationFiled: August 7, 2013Publication date: January 16, 2014Applicant: Chemsil Silicones, Inc.Inventors: James Jefferies Harrison, Nohemi Harrison
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Publication number: 20140010870Abstract: The present invention relates to a pharmaceutical composition comprising solutions, suspensions of dispersions of inositol, or an isomer thereof, in a vehicle comprising gelatin, glycerol or mixtures thereof.Type: ApplicationFiled: March 21, 2012Publication date: January 9, 2014Applicant: LO.LI. PHARMA S.R.L.Inventor: Vittorio Unfer
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Patent number: 8623340Abstract: The present invention relates to antimicrobially active ?-cyclohexylalkan-1-oles of the following formula (I), to a method for producing said compounds and to the use thereof as antimicrobial agents for treating body odor, wherein R1 to R6 independently of one another denote hydrogen or a linear or branched alkyl radical having 1 to 12 carbon atoms, Ra and Rb independently of one another denote hydrogen, a linear or branched alkyl radical having 1 to 6 carbon atoms or a linear or branched alkoxy radical having 1 to 4 carbon atoms, and x is 0 or 1, wherein preferably the total number of carbon atoms in R1 to R6 is 18 or less.Type: GrantFiled: April 28, 2009Date of Patent: January 7, 2014Assignee: Symrise AGInventors: Walter Kuhn, Ingo Wöhrle, Erich Dilk, Christian Ewering, Jörg Mampel, Michael Krohn, Holger Zinke
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Publication number: 20130344128Abstract: The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex-induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a compositions comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; (+)-Carvone; alpha-Terpineol; Cardinene; d-Carvone; 1-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Ci mene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.Type: ApplicationFiled: April 4, 2013Publication date: December 26, 2013Applicant: TissueTech, Inc.Inventor: TissueTech, Inc.
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Publication number: 20130344007Abstract: This disclosure relates to a composition that may include frankincense resin and various combinations of essential oils, which combinations may be effective in promoting weight loss. The present disclosure further relates to a weight loss and satiation composition that may include frankincense resin and a flavorant. In some embodiments, the composition may include a gum base.Type: ApplicationFiled: June 26, 2012Publication date: December 26, 2013Applicant: YL HOLDINGS, INC.Inventors: D. Gary Young, Marc Schreuder, Janelle Pack
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Patent number: 8613946Abstract: Carotenoid compositions of enhanced solubility and bioavailability are described that contain at least one carotenoid with at least one solubility-enhancing polymer. In one embodiment, the carotenoid is a provitamin A carotenoid such as ?-carotene. In another embodiment the carotenoid is a non-provitamin A carotenoid such as lycopene or lutein. Described methods to produce the bioenhanced products include dry blending and solvent spray drying. In accordance with certain embodiments of the invention, the method includes the steps of providing a mixture comprising the carotenoid, a solubility-enhancing polymer and a solvent and removing the solvent to produce an amorphous form of the carotenoid. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.Type: GrantFiled: December 21, 2007Date of Patent: December 24, 2013Assignee: ISP Investment Inc.Inventor: John A. Doney
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Publication number: 20130338234Abstract: The present invention relates to a method for the direct extraction or dispersion and concentration of naturally-derived active compounds into food-grade edible solvents or excipients directly usable in food, nutraceutical, pharmaceutical or cosmetic products without the use of synthetic organic solvents or organic solvents derived from petroleum or petrochemical products. The method involves a treatment of a multi-component biomass solvent system with microwave energy having a generally uniform high electric field intensity.Type: ApplicationFiled: June 19, 2013Publication date: December 19, 2013Inventors: Steven Splinter, Jocelyn J.R. Pare, Satyasagar Kadali
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Publication number: 20130331459Abstract: Disclosed are 19-nor-vitamin D compounds, and specifically seco-A-2,19-dinor-1,25-dihydroxyvitamin D3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high activity in vivo, specifically in intestinal tissues, but relatively low VDR binding activity, cell differentiation activity and gene transcription activity. There is thus potential for these compounds to have strong cell selectivity for use as therapeutic agents against some cancers, such as colon cancer or polyps, as well as hyperplastic intestinal disorders, such as Crohn's disease, ulcerative colitis and celiac disease. These compounds also have relatively high intestinal calcium transport activity evidencing potential in the treatment of bone diseases.Type: ApplicationFiled: March 14, 2013Publication date: December 12, 2013Applicant: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Margaret Clagett-Dame, Lori A. Plum, Agnieszka Glebocka
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Publication number: 20130317098Abstract: (Modified) sorghum protein is used as novel protective hydrocolloid for active ingredients, especially fat-soluble active ingredients and/or colorants. Included are compositions comprising (modified) sorghum protein and at least one active ingredient and to their manufacture, as well as to the (modified) sorghum protein itself and its manufacture. These compositions are used for the enrichment, fortification and/or coloration of food, beverages, animal feed, personal care or pharmaceutical compositions, and to food, beverages, animal feed, personal care and pharmaceutical compositions containing such a (modified) sorghum protein and such a composition, respectively.Type: ApplicationFiled: November 10, 2011Publication date: November 28, 2013Inventor: Christian Schaefer
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Publication number: 20130302319Abstract: A composition comprising a pharmaceutically effective amount of zeaxanthin or its derivative for use in treating a malignant tumor and a method of using a pharmaceutically effective amount of zeaxanthin or its derivative either alone or together with one or more pharmaceutical agents for treating a malignant tumor. The tumor may be, but is not limited to breast cancer, cervix cancer, colon cancer, cutaneous melanoma, cutaneous squamous carcinoma, hepatocellular carcinoma, lung cancer, osteosarcoma, prostate cancer, and uveal melanoma. The pharmaceutically effective amount of zeaxanthin is generally above about 0.5 mg/kg/d to about 20 mg/kg/d.Type: ApplicationFiled: March 15, 2013Publication date: November 14, 2013Applicant: The New York Eye and Ear InfirmaryInventors: Richard B. Rosen, Dan-Ning Hu
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Publication number: 20130296442Abstract: The invention relates to the improvement of visual performance, particularly of visual performance in the darkness, by administration of a colorant that is capable of being incorporated into eye tissue and/or causing yellowing of eye tissue, especially carotenoids, such as lutein and zeaxanthin.Type: ApplicationFiled: June 14, 2013Publication date: November 7, 2013Applicant: DSM IP ASSETS B.V.Inventors: Felix BARKER, Regina Goralczyk, Wolfgang Schalch
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Publication number: 20130289102Abstract: The present invention relates to formulations comprising amyris alcohol or an ester of amyris alcohol or combinations thereof to treat acne in humans. These formulations can further comprise a phytoestrogen such as glabridin and miroestrol, an antioxidant such as tetrahydrocurcumin and naturally occurring peroxides such as artemisinin and dihydroartemisinin and combinations thereof for improved effectiveness in treating acne.Type: ApplicationFiled: December 22, 2011Publication date: October 31, 2013Applicant: Trinity Laboratories, Inc.Inventors: Chandra Ulagaraj Singh, Jagaveerabhadra Rao Nulu
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Publication number: 20130281545Abstract: A carotenoid substance called zeaxanthin, when ingested orally at suitable dosages such as 30 to 100 mg/day for a span of 1 to 2 weeks, can provide effective protection against sunburns, and can give skin a darker tint that emulates a healthy suntan. In tests involving adults, it was found that zeaxanthin dosages of 30 to about 80 mg per day were sufficient to induce: (i) a mild but noticeable tinting, shading, or darkening of skin color, comparable to a mild suntan; (ii) a substantial increase in the person's ability to withstand elevated levels of sun or UV exposure without any subsequent pain or discomfort, and without the subsequent peeling and flaking that characterizes sunburns; and, (iii) an increased ability of reddened and sunburned skin to convert into intact skin that looks browned and healthily tanned.Type: ApplicationFiled: June 11, 2013Publication date: October 24, 2013Inventors: Dennis L. Gierhart, Joseph A. Fox
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Patent number: 8563053Abstract: A composition and method for treating a bone condition of an animal. The composition includes a nanoformulation of active ingredients. The active ingredients include Lepidium Sativum or other Lepidium extracts, calcium, vitamin D, and antioxidants. The method for treating a bone condition includes introducing the composition into the animal.Type: GrantFiled: October 27, 2010Date of Patent: October 22, 2013Inventors: Shaker A. Mousa, Mohammed H. Qari, Mohammed S. Ardawi
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Publication number: 20130274256Abstract: Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.Type: ApplicationFiled: October 11, 2012Publication date: October 17, 2013Applicant: SEQUOIA SCIENCES, INC.Inventor: Sequoia Sciences, Inc.
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Publication number: 20130274240Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.Type: ApplicationFiled: November 5, 2012Publication date: October 17, 2013Inventor: JAPAN TOBACCO INC.