Polycyclo Ring System Patents (Class 514/766)
  • Patent number: 7723393
    Abstract: The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: May 25, 2010
    Assignee: GlaxoSmithKline LLC
    Inventors: Jing Fang, Dennis Heyer, Subba Reddy Katamreddy, Kenneth William Batchelor, Richard Dana Caldwell
  • Publication number: 20100092404
    Abstract: A process for the hydrogenation of a mixture of caryophyllenes by contact with hydrogen in the presence of a supported catalyst. The resulting products are useful for the application to skin.
    Type: Application
    Filed: December 20, 2007
    Publication date: April 15, 2010
    Applicant: E.I. DU PONT DE NEMOURS AND COMAPNY
    Inventors: Keith W. Hutchenson, Scott Christopher Jackson, Leo Ernest Manzer, Mark A. Scialdone, Mayis Seapan
  • Patent number: 7666900
    Abstract: To provide a pharmaceutically effective prophylactic/preventive agent for low-HDL cholesterolemia, focusing on an HDL-generating mechanism. The ABCA1 stabilizer of the present invention contains a bisphenol-type compound selected form probucol spiroquinone, probucol diphenoquinone, and probucol bisphenol as an effective ingredient. The ABCA1 stabilizer can continuously and stably express ABCA1 by a mechanism quite different from that of conventional processes, and thus is useful as prophylactic/preventive agent for low-HDL cholesterolemia or arteriosclerosis.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: February 23, 2010
    Assignee: Hykes Laboratories LLC
    Inventors: Shinji Yokoyama, Maki Tsujita, Reijiro Arakawa, Tomoji Aotsuka
  • Patent number: 7638662
    Abstract: Compounds of the formula (I): wherein each of R1-R12 is independently hydrogen or a linear C1-20 alkyl group each of A1 and A2 is a 1, 2 or 3 ring carbon atom wherein A1 is substituted by R9 and R10 and A2 is substituted by R11 and R12; and wherein at least one of R1-R12 is a linear alkyl group having from 1 to 20 carbon atoms are emollients for use in cosmetics, lubricants and pharmaceutical preparations.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: December 29, 2009
    Assignee: COGNIS IP Management
    Inventors: Achim Ansmann, Sabine Both, Daniela Prinz, Nicole Schoeffler, Alfred Westfechtel
  • Patent number: 7632870
    Abstract: The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabetes, obesity, hypertension, inflammatory diseases, cancers or neoplasms (benign or malignant tumors), neurodegenerative, dermatological diseases and disorders related to oxidative stress, for preventing or treating the effects of ageing in general and for example skin ageing, in particular in the field of cosmetics (occurrence of wrinkles and the like).
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: December 15, 2009
    Assignee: Genfit
    Inventors: Jamila Najib, Karine Caumont-Bertrand
  • Patent number: 7625947
    Abstract: This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1?OCHO, R2?H, R3?COOH, R4 & R5?O 2. R1?OCOCH2Cl, R2?H, R3?COOH, R4 & R5?O 3. R1?5?-O-methylgalloyloxy, R2?H, R3?COOH, R4 & R5?O 4. R1?OCOCH2CH2COOH, R2?H, R3?COOH, R4 & R5?O 5. R1?8?,9?-Dihydro-4?-hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 6. R1?4?-Hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 7. R1?3?,4?-Dimethoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 8. R1?3?,4?-Dihydroxy-5?-methoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 9. R1?OCOCH2NH(tert-BOC), R2?H, R3?COOCH3, R4 & R5?O 10. R1?OCOCH2NH2HCl, R2?H, R3—COOH, R4 & R5?O 11. R1?OCOCH(CH3)NH2HCl, R2?H, R3?COOH, R4 & R5?O 12. R1?H, R2?OH, R3?COOCH3, R4 & R5?O 13. R1?H, R2?Br, R3 COOCH3, R4 & R5?O 14. R1?CN, R2?H, R3?COOCH3, R4 & R5?O 15. R1?SH, R2?H, R3?COOCH3, R4& R5?O 16. R1 & R2?N(OH), R3?COOCH3, R4 & R5?O 17.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: December 1, 2009
    Assignee: Laila Nutraceuticals
    Inventors: Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Subbaraju Gottumukkala, Trimurtulu Golakoti
  • Publication number: 20090232765
    Abstract: A method to improve the efficiency of refuge crops in preventing the development of insects that are resistant to an insecticide. The method involves using an attractant to lure insects to the refuge and increase the population of survivors. The protected crops include cotton and corn. The refuge crop may be the same crop, a different crop, or a naturally occurring plant population.
    Type: Application
    Filed: April 1, 2005
    Publication date: September 17, 2009
    Inventor: Stewart J. Addison
  • Publication number: 20090197949
    Abstract: The present invention relates to novel antitumor compositions, the use of sesquiterpene derivatives as antitumor agents and to methods of treatment thereof. More precisely, The present invention relates to an antitumor composition comprising a therapeutically effective quantity of at least one sesquiterpene derivative in association with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 10, 2009
    Publication date: August 6, 2009
    Applicant: F.P.L. Pharma, Inc.
    Inventors: Andre PICHETTE, Jean Legault, Jean-Claude Madelmont
  • Patent number: 7510726
    Abstract: This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: March 31, 2009
    Assignee: Acura Pharmaceuticals, Inc.
    Inventors: Vijai Kumar, David Dixon, Divya Tewari, Dilip B. Wadgaonkar
  • Publication number: 20090031435
    Abstract: This invention relates to therapies for diseases involving splicing defects, such as spinal muscular atrophy (SMA), and methods to identify compounds for treating this disease. The invention specifically provides for therapies comprised of small molecule compounds identified by cell-based high-throughput screening assays. These assays utilize engineered splicing constructs that fuse pre-mRNA fragments to a reporter gene. The fragments contain exons and at least one intron of a gene mutated in such a way to cause disease. Additionally, the invention provides for methods to monitor the effects of drugs on splicing and gene expression in vivo, in transgenic animals.
    Type: Application
    Filed: November 29, 2007
    Publication date: January 29, 2009
    Inventors: Brent R. Stockwell, David E. Root
  • Publication number: 20080300319
    Abstract: In accordance with one aspect of the invention, a method is provided in which post-surgical adhesions at a surgical site in a patient are prevented or inhibited. The method comprises topically applying a liquid composition comprising a hydrophobic species, which has a melting point above normal body temperature, to tissue at the surgical site in an amount effective to prevent or inhibit the formation of adhesions during healing. Application of the liquid composition results in the formation of a solid adhesion barrier layer on the tissue. Moreover, the properties of the hydrophobic species are such that the adhesion barrier sublimes in vivo after the surgical site is closed.
    Type: Application
    Filed: May 29, 2008
    Publication date: December 4, 2008
    Applicant: Boston Scientific Scimed, Inc.
    Inventor: Jon T. McIntyre
  • Publication number: 20080220038
    Abstract: There is disclosed method of killing nematodes comprising the step of applying an effective amount of a nematicidal composition comprising a terpene component and compositions suitable for use in the method. The terpene component is preferably in association with water, either as a solution or a suspension. An excipient may also be included, which is suitably hollow glucan particles which encapsulate the terpene component.
    Type: Application
    Filed: January 24, 2005
    Publication date: September 11, 2008
    Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff
  • Publication number: 20080199458
    Abstract: A composition for influenza treatment includes an immune enhancer and an anti-viral agent
    Type: Application
    Filed: January 16, 2008
    Publication date: August 21, 2008
    Inventors: Jian-Er LIN, Wei Dong Xie, Kee Hung Chu
  • Publication number: 20080145462
    Abstract: Compositions for treating parasitic infections and methods of using the compositions to treat subjects with parasitic infections are provided. Methods of selecting compositions for use in treating parasitic infections are further provided.
    Type: Application
    Filed: June 27, 2007
    Publication date: June 19, 2008
    Inventor: Essam Enan
  • Patent number: 7250157
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 31, 2007
    Assignee: Applied Genetics Incorporated Dermatics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Patent number: 7201920
    Abstract: This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: April 10, 2007
    Assignee: Acura Pharmaceuticals, Inc.
    Inventors: Vijai Kumar, David Dixon, Divya Tewari, Dilip B. Wadgaonkar
  • Patent number: 7176189
    Abstract: The invention relates to methods for transdifferentiation of body tissues which can be used to generate specific cell types needed for regenerating a lens in the mammalian eye, following loss or removal of the original lens.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: February 13, 2007
    Inventor: Steven Baranowitz
  • Patent number: 7052716
    Abstract: Cosmetic and dermatological preparations having an effective content of bile acids, their salts and/or their derivatives, it being possible for said active ingredients to be present either individually or as a mixture.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: May 30, 2006
    Assignee: Beiersdorf AG
    Inventors: Ghita Lanzendörfer, Volker Schreiner
  • Patent number: 6955804
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: October 18, 2005
    Assignee: Applied Genetics Incorporated Dematics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Patent number: 6906108
    Abstract: Extracts of vetiver oil were found to be significant repellents and toxicants of ants, ticks, and cockroaches. Nootkatone was shown to significantly decrease ant invasion and increase mortality in fire ants. Nootkatone is an effective repellent and toxicant of ants either by itself or as an addition to other substrates, including mulches made from vetiver grass roots, diatomaceous earth, alumina, silica, clays; building materials made from either aluminum or wood; and other suitable solid substances. Nootkatone was also a repellent and toxicant to ticks; and a repellent to cockroaches. Nootkatone is non-toxic to humans and other mammals and is environmentally safe. In addition, it is believed that other extracts of vetiver oil, specifically ?-cedrene, zizanol and bicyclovetivenol, will be effective against ants, ticks, and cockroaches.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: June 14, 2005
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Gregg Henderson, Donald O. Heumann, Roger A. Laine, Lara Maistrello, Betty C. R. Zhu, Feng Chen
  • Patent number: 6849276
    Abstract: The invention concerns a phytosanitary fungicide, bactericidal or bacteriostatic composition comprising at least a mineral salt, a copper oxide or hydroxide suspended in an aqueous emulsion of at least a terpene derivative.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: February 1, 2005
    Assignee: Action Pin
    Inventors: Ghislain Dufau, Michel Barsacq, Gérard Molla
  • Patent number: 6790463
    Abstract: The use of a pharmaceutical formulation in treating coronary arteriosclerosis and a two-component pharmaceutical formulation. The pharmaceutical formulation contains peroxidic species or reaction products resulting from oxidation of an alkene, such as geraniol, by an oxygen-containing oxidizing agent, such as ozone; a penetrating solvent, such as dimithyl sulfoxide; a dye containing a chelated metal, such as hematoporphyrin; and an aromatic redox compound, such as benzoquinone.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: September 14, 2004
    Inventors: Robert F. Hofmann, Robert H. Carpenter
  • Patent number: 6773727
    Abstract: Low concentrations of gossypol and related phyllophage toxins from cotton improve the effectiveness of insecticidal agents against social insects, including cockroaches, and particularly termites and ants. Levels of gossypol and other cotton phyllophage toxins which are sufficiently low as to be non-biocidal to social insects alone, will significantly increase the control efficacy of other insecticidal agents. Consequently, use of these low levels of these cotton phyllophage toxins allows the levels of insecticidal agents necessary for effectively controlling the insects to be significantly reduced relative to applications without cotton phyllophage toxins. Furthermore, insecticidal agents which are normally ineffective for control of social insects when used alone, may be effective when used in conjunction with the cotton phyllophage toxins.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: August 10, 2004
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Maria G. Rojas, Juan A. Morales-Ramos, Peter J. Wan
  • Patent number: 6703014
    Abstract: A method has been discovered for attracting Colorado potato beetles to an area of object or area, which method involves treating the object or area with a Colorado potato beetle attracting composition (with or without an insecticide) containing a carrier material and a Colorado potato beetle attracting effective amount of (a) (Z)-3-hexenyl acetate, (±)-linalool, nonanal, and methyl salicylate, (b) (Z)-3-hexenyl acetate, (±)-linalool, and methyl salicylate, (c) (Z)-3-hexen-1-ol, (E)-2-hexen-1-ol, and (±)-linalool, (d) (Z)-3-hexenyl acetate and methyl salicylate, or (e) (Z)-3-hexenyl acetate and (±)-linalool.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: March 9, 2004
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Joseph C. Dickens, A. Randall Alford
  • Publication number: 20040044086
    Abstract: The present invention relates to a gel composition on alcoholic basis, comprising at least one androgenic steroid and at least one C3-C4 diol as enhancer, as well as the use of a composition comprising at least one androgenic steroid on the scrotum for the treatment and/or prophylaxis of hypogonadism.
    Type: Application
    Filed: September 23, 2003
    Publication date: March 4, 2004
    Inventors: Bernd Schulze, Eberhard Nieschlag
  • Patent number: 6660288
    Abstract: The use of specific perfume ingredients, e.g. tricyclodecenyl allyl ether, to repel insects. The perfume ingredients may be used in a composition comprising from 0.1 to 40 percent by weight of one or more of the perfume ingredients. Preferably at least one of the perfume ingredients has a hydrophobicity such that the common logarithm of the octanol-water partition coefficient, log P, of the perfume ingredient is in the range 1.0 to 6.0.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: December 9, 2003
    Assignee: Quest International B.V.
    Inventors: John Martin Behan, Richard Arthur Birch
  • Patent number: 6623724
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: September 23, 2003
    Assignee: Applied Genetics Incorporated Dermatics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Patent number: 6613771
    Abstract: A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: September 2, 2003
    Assignee: The Regents of the University of California
    Inventors: Simon H. Friedman, Raymond F. Schinazi, Fred Wudl, Craig L. Hill, Diane L. DeCamp, Rintje P. Sijbesma, George L. Kenyon
  • Patent number: 6479046
    Abstract: A method has been discovered for attracting Colorado potato beetles to an area of object or area, which method involves treating the object or area with a Colorado potato beetle attracting composition (with or without an insecticide) containing a carrier material and a Colorado potato beetle attracting effective amount of (a) (Z)-3-hexenyl acetate, (±)-linalool, nonanal, and methyl salicylate, (b) (Z)-3-hexenyl acetate, (±)-linalool, and methyl salicylate, (c) (Z)-3-hexen-1-ol, (E)-2-hexen-1-ol, and (±)-linalool, (d) (Z)-3-hexenyl acetate and methyl salicylate, or (e) (Z)-3-hexenyl acetate and (±)-linalool.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: November 12, 2002
    Inventors: Joseph C. Dickens, A. Randall Alford
  • Patent number: 6461638
    Abstract: Pharmaceutical compositions for rectal administration comprising an effervescent mixture comprising sodium bicarbonate and glutamic acid or pyroglutamic acid with at least one diluent adapted for rectal administration, said mixture being effervescent.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: October 8, 2002
    Assignee: Techni-Pharma
    Inventor: Axelle Note-Simonnard
  • Patent number: 6458834
    Abstract: The present invention relates to fuingicidally effective compositions containing at least one pentacyclic triterpene compound.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: October 1, 2002
    Assignee: Micro Flo Company
    Inventors: Jan Glinski, Keith L. Branly
  • Patent number: 6433010
    Abstract: The present invention relates to fungicidally effective compositions containing at least one pentacyclic triterpene compound.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: August 13, 2002
    Assignee: Micro Flo Company
    Inventors: Jan Glinski, Keith L. Branly
  • Patent number: 6352703
    Abstract: Significant concentrations of naphthalene were detected in carton nests of Formosan subterranean termites, Coptotermes formosanus Shiraki, collected from Florida, Hawaii, and Louisiana. This is the first report of naphthalene being associated with termites or any other insects. Naphthalene and other compounds associated with termite carton nests may be used to increase termite bait acceptance. New attractant molecules include 2-phenoxyethanol. New feeding stimulants include ergosterol. A list of volatile compounds associated with termite nests is presented, compounds that may be used to detect termite nests.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: March 5, 2002
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Gregg Henderson, Jian Chen, Roger A. Laine
  • Patent number: 6337078
    Abstract: Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one system wherein the system comprises at least one bioactive agent as a component selected for treating a population of aquatic organisms, at least one carrier component, and at least one coating component for regulating the controlled release rate and release profile of the bioactive agent in water or at least one bioactive agent and one joint-function component that can serve as both a carrier and coating to regulate the controlled release rate and release profile of the bioactive agent in water, with or without optional binder components and/or additional formulation materials. The components are selected to sink or float so that the complexes will permeate and/or remain in any planar or volumetric segment of a water column for a period of time that is sufficient to effectively treat a population of aquatic organisms.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: January 8, 2002
    Assignee: Lee County Mosquito Control District
    Inventor: Richard Levy
  • Patent number: 6337337
    Abstract: A method for treating disorders responsive to DHFR inhibition is disclosed, wherein the disorders may include neoplastic diseases, rheumatoid arthritis, restenosis, multiple sclerosis, lupus, infections, and ectopic pregnancy. The inventive method comprises administering to a patient in need of treatment a therapeutically-effective amount of a composition comprising certain aromatic, primarily non-aliphatic, molecules that may be found in coal tar.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: January 8, 2002
    Inventor: Carol J. Buck
  • Patent number: 6309677
    Abstract: A composition is provided that includes carotenoid extracts derived from a plurality of natural sources. Carotenoids are extracted from natural sources such as palm fruit, algae and marigold flowers and combined in a single product. The product may include carriers such as yellow bees wax, soybean oil and lecithin and may be in a form suitable for oral ingestion.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: October 30, 2001
    Assignee: Amway Corporation
    Inventors: David Gorenbein, Idrees A. Siddiqui, Ernie R. Ceja, Christine M. Horvath
  • Patent number: 6290937
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: September 18, 2001
    Assignee: Applied Genetics Incorporated Dermatics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Patent number: 6177415
    Abstract: The arachidonic acid-metabolizing hopanoid tetrahydroxybacteriohopane (THBH) was isolated from Zymomonas mobilis and was found to inhibit soybean 15-lipoxygenase, and thus lipoxin biosynthesis, with an IC50 of about 10 &mgr;M. The activities of two other arachidonic acid-metabolizing enzymes, human 5-lipoxygenase (involved in prostaglandin biosynthesis) and prostaglandin H synthase, were unaffected by THBH. Subsequent studies showed that THBH was effective as an anti-inflammatory agent in topical applications.
    Type: Grant
    Filed: April 21, 1997
    Date of Patent: January 23, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Robert A. Moreau, Kevin B. Hicks
  • Patent number: 6090823
    Abstract: (+)-N,N'-Propylene dinicotinamide or pharmaceutically acceptable salts thereof are outstanding drugs of high safety that can heal or ameliorate spinal cord injuries, prevent the transition from an incomplete cord injury to a complete injury, and minimize the consequences of spinal cord injuries including neurological disorders such as quadriplegia, paralysis of the respiratory muscle, damage to sensory functions and impairment of reflex functions, as well as impaired urinating or defecating functions.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: July 18, 2000
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventor: Toshizo Ishikawa
  • Patent number: 6075050
    Abstract: This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 13, 2000
    Assignee: Procept, Inc.
    Inventors: Shyam K. Singh, Raymond J. Patch, Peter V. Pallai, Edith A. Neidhardt, Gerard P. Palace, Kevin J. Willis, Theresa M. Sampo, Kevin W. McDonald, Zhan Shi
  • Patent number: 6074634
    Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: June 13, 2000
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
  • Patent number: 6054490
    Abstract: The invention relates to the use of a sesquiterpene for inhibiting an oxidative enzyme, preferably a cytochrome P450 enzyme. The invention also relates to compositions comprising a sesquiterpene and a drug which exhibits instability in the presence of an oxidative enzyme.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: April 25, 2000
    Assignee: Zylepsis Limited
    Inventors: John Thomas Sime, Peter Samuel James Cheetham, Michelle Lorraine Gradley, Nigel Eric Banister
  • Patent number: 6028117
    Abstract: Disclosed herein are microemulsion insecticides that do not contain conventional actives. The microemulsion form permits insects to be killed by an oil/surfactant combination.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: February 22, 2000
    Assignee: S. C. Johnson & Son, Inc.
    Inventor: John D. Hagarty
  • Patent number: 6020327
    Abstract: A method for treating hair loss is disclosed by topically adminstering an aromatase inhibitor to a mammal, including humans, on the area to be treated.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: February 1, 2000
    Assignees: The Central Sheffield University Hospitals NHS Trust, Bio-Scientific Ltd
    Inventor: Andrew Guy Messenger
  • Patent number: 6001874
    Abstract: A non-toxic arthropod control composition is disclosed for application to foliage for plant protection. The composition includes behavior interfering compounds, agricultural oil and/or surface active compounds and diluents. The behavior interfering compounds may be any known conventional compound capable of interrupting or altering the normal behavioral sequences of the target. The agricultural oil can be a vegetable oil.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: December 14, 1999
    Inventor: Dan Veierov
  • Patent number: 5989555
    Abstract: Larrea tridentata and Ambrosia deltoidea are shown to produce compounds that inhibit replication of HIV. The compounds can be extracted by differential fractionation and by counter-current chromatographic methods described herein. Extracts prepared from L. tridentata and A. deltoidea are found to be effective in inhibiting viral replication. The extracts from L. tridentata have been characterized and found to contain tricyclic lignans. The extracts can be administered to subjects for treatment of viral infection.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: November 23, 1999
    Inventor: John N. Gnabre
  • Patent number: 5910323
    Abstract: This invention provides a novel aqueous pesticide formulation having a fungicidal bicarbonate-containing inorganic salt ingredient which enhances the efficacy of an insecticidal ingredient for treatment of cultivated crops. An invention pesticide formulation also contains a water-soluble organic compound which functions as a compatibility enhancing ingredient in the aqueous pesticide formulation, and improves the spreadability and adhesiveness of the composition ingredients when applied to foliage.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: June 8, 1999
    Assignee: Church & Dwight Co., Inc.
    Inventors: M. Stephen Lajoie, Amy L. Joseph, Keith A. Jones, Anthony E. Winston
  • Patent number: 5834437
    Abstract: The object of the present invention is to provide asiatic acid derivatives, its pharmaceutically acceptable salts or esters.Asiatic acid, its trisaccharide asiaticoside and mddecassic acid, extracted from Centella asiatica have been used for a long time in the management of skin scars and chronic ulcers. In this invention, asiatic acid derivatives synthesized from asiatic acid show excellent wound-healing properties.
    Type: Grant
    Filed: December 1, 1995
    Date of Patent: November 10, 1998
    Assignee: Dong Kook Pharmaceutical Co., Ltd.
    Inventors: Sang-Sup Jew, Hee-Doo Kim, Young-Hoon Jung, Eun-Hee Park, Sung-Ki Seo, Tae-Gyu Nam, Duc-Ky Hahn, Jae-Ho Park, Pil-Jong Sim, Min-Jung Lim, Kyung-Haw Lim
  • Patent number: 5814325
    Abstract: Closely related formulations of GRAS food additives serve as insect repellents, insecticides and larvicides. The ingredients of the repellent, insecticide and larvicide also exhibit useful disinfectant properties against vector-borne pathogenic micro-organisms.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: September 29, 1998
    Assignee: The Rod Family Trust
    Inventor: Robert L. Rod
  • Patent number: 5750578
    Abstract: A therapeutic method is provided for treating a mammal afflicted with a herpesvirus infection comprising administering an effective amount of betulin or a derivative thereof.
    Type: Grant
    Filed: February 11, 1997
    Date of Patent: May 12, 1998
    Assignee: Regents of The University of Minnesota
    Inventors: Robert M. Carlson, Pavel A. Krasutsky, M. Reza-Ul Karim