Carboxylic Acid Ester Patents (Class 514/785)
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Publication number: 20140186279Abstract: The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.Type: ApplicationFiled: December 23, 2013Publication date: July 3, 2014Applicant: CAMURUS ABInventors: Fredrik JOABSSON, Margareta LINDEN, Krister THURESSON, Fredrik TIBERG
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Publication number: 20140187489Abstract: The present invention provides a composition comprising or consisting of components (a) (i) at least one mono-alkanoyl glycerol ester, wherein alkanoyl is selected from C4 to C21 alkanoyl, preferably from octanoyl and decanoyl; and (b) (i) at least one compound selected from cholesterol, phosphatidyl cholines and phosphatidyl glycerols, wherein the acyl moieties of the phosphatidyl moieties are independently selected from C6 to C21 alkanoyl and C6 to C21 alkenoyl.Type: ApplicationFiled: May 25, 2012Publication date: July 3, 2014Applicant: ARISGEN SAInventors: Paolo Botti, Sylvie Tchertchian
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Patent number: 8765173Abstract: A drug delivery system (DDS) for administration of a water soluble, cationic, and amphiphilic pharmaceutically active substance (API) which DDS comprises poorly water soluble nanoparticles formed by the API together with a Na-salt of N-all-trans-retinoyl cysteic acid methyl ester and/or a Na-salt of N-13-cis-retinoyl cysteic acid methyl ester. A pharmaceutical composition comprising such a DDS. Methods for preparation of such a DDS and such a pharmaceutical composition. Use of such a DDS and pharmaceutical composition for treatment of cancer.Type: GrantFiled: December 18, 2008Date of Patent: July 1, 2014Assignee: Ardenia Investments, Ltd.Inventors: Julian Aleksov, Igor Lokot
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Publication number: 20140178314Abstract: Personal care compositions for use in an absorbent article are disclosed comprising an isosorbide diester having the formula: wherein R? and R? are independently selected from a straight or branched C1-30 chain, which may be saturated or unsaturated. The personal care compositions also comprise a solid cosmetic active soluble in the isosorbide diester and a dermatologically acceptable carrier. The personal care composition may be in the form of an emulsion. A personal care composition is also disclosed comprising an isosorbide diester having the formula: wherein R? and R? are independently selected from a straight or branched C1-30 chain which may be saturated or unsaturated and Z1-Z6 are independently selected from hydrogen, hydroxyl, amino, amido, R?, or R?. Methods of making the aforementioned personal care compositions are also disclosed.Type: ApplicationFiled: December 16, 2013Publication date: June 26, 2014Applicant: The Procter & Gamble CompanyInventors: Paul Robert Tanner, Larry Richard Robinson
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Publication number: 20140178507Abstract: A composition for oral administration for weight management includes at least approximately ? (by weight) active or nutritional ingredients, and may include as much as and approximately ? (by weight) of sweetening, flavoring and/or palatability ingredients. The composition is free of caffeine and free of added sugars.Type: ApplicationFiled: December 21, 2012Publication date: June 26, 2014Applicant: CRAVING CRUSHER, LLCInventor: Om AGARWALA
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Patent number: 8758811Abstract: The present invention provides a multilayer vehicle, including a mesoporous silica core and a lipid bilayer coating thereon. Hydrophobic molecules are formed between the silica core and lipid layer. Additionally, methods and uses of the multilayer vehicle are also provided.Type: GrantFiled: November 22, 2010Date of Patent: June 24, 2014Assignee: National Tsing Hua UniversityInventors: Ja-An Ho, Li-Sheng Wang, Chia-Min Yang, Li-Chen Wu
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Publication number: 20140170097Abstract: The invention provides compositions and methods for reversible covalent binding of benefit agents to keratinous substrates through the reaction of a dicarbonyl functional group on the surface of a benefit agent with reactive amines on keratinous surfaces. The deposits formed are durable and resistant to transfer, but are readily removed by contacting the deposit with an amine-containing solution.Type: ApplicationFiled: December 18, 2012Publication date: June 19, 2014Applicant: AVON PRODUCTS, INC.Inventors: Sung Bin Shin, Sen Yang
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Publication number: 20140155495Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.Type: ApplicationFiled: November 21, 2013Publication date: June 5, 2014Applicant: PHOSPHAGENICS LIMITEDInventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
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Publication number: 20140150380Abstract: Disclosed are compounds of formula (1) and (2) and/or E/E-, E/Z- or Z/Z geometrical isomer forms thereof; wherein R1-R5, R1-R11 and A are defined as in description. The compounds are used as UV absorbers for protecting household products from photolytic and oxidative degradation, as plastic additives, preferably for food and pharmaceutical packaging applications, for preventing photo-degradation of food by incorporation of the compounds of formula (1?) and/or (2?) into transparent food containers, for protection of UV-A sensitive drugs from photo-degradation by incorporation of UV absorber in transparent blister foils or transparent pharmacy containers, as additives for photographic and printing applications, as additives for electronic applications and protecting the ingredients in agriculture applications.Type: ApplicationFiled: July 19, 2012Publication date: June 5, 2014Inventors: Barbara Winkler, Dietmar Hueglin, Kai Eichin, Larissa Ehrsam, Xavier Marat, Hervé Richard, ILona Marion Kienzle, Ute Schroeder
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Publication number: 20140148516Abstract: The purpose of the present invention is to provide a water-in-oil type cosmetic which ensures emulsion stability in the case where a volatile hydrocarbon oil component is added, has excellent texture such as not leaving a greasy feeling, and is highly compatible with the skin. The present invention relates to a water-in-oil type emulsified cosmetic comprising: (A) 20 to 30 mass % of an oil component; (B) a fatty acid ester having an HLB of 5 to 10; (C) a nonionic surfactant having an HLB of 1 to 4; (D) an organic modified clay mineral; and (E) water, wherein volatile hydrocarbon oil accounts for 10 mass % or more of the oil component (A) and silicone oil is not contained.Type: ApplicationFiled: October 5, 2011Publication date: May 29, 2014Inventors: Kazutaka Sasaki, Takayuki Omura, Masaki Kitajima
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Publication number: 20140142203Abstract: Provided is a cosmetic composition which has a structure-recovering property, is transparent, is excellent in thermal stability, is satisfactory in smoothness when applied to the skin or hair, and has a good feeling in use, and which comprises components (A) to (D) as described.Type: ApplicationFiled: July 6, 2012Publication date: May 22, 2014Inventors: Yoji Tezuka, Muneaki Iizuka
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Publication number: 20140135408Abstract: Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R1 is H or CH3, a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R51, R52, R53 are independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group attached, preferably to the terminal end of R51, R52, R53, X is O or NR54, where R54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R2 and R3 are independently an alkyl, alkyl ether, or a substituted or non-substituted aromatic group, preferred R2 and R3 include methyl, ethyl, and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, and substiType: ApplicationFiled: February 1, 2012Publication date: May 15, 2014Applicant: DSM IP ASSETS B.V.Inventors: Shanger Wang, Xuwei Jiang, Yuan Tian
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Publication number: 20140134125Abstract: The invention relates to microemulsions which comprise, as oil phase, a polysiloxane containing at least one quaternary ammonium group, methods for production thereof and also to the use of such microemulsions.Type: ApplicationFiled: March 19, 2012Publication date: May 15, 2014Applicant: EVONIK DEGUSSA GMBHInventors: Verena Dahl, Sascha Herrwerth, Christian Hartung, Joachim Venzmer, Dirk Kuppert, Berend-Jan De Gans
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Publication number: 20140127320Abstract: A composition and method adapted for delivery of hydrophilic, biologically-active agents are disclosed. The composition can include a reverse microemulsion formed from at least one hydrophilic, biologically-active agent solubilized by a hydrophobic reverse emulsion surfactant in a non-stinging, volatile, hydrophobic solvent. The non-stinging, volatile, hydrophobic solvent is selected from the group consisting of volatile linear and cyclic siloxanes, volatile linear, branched, and cyclic alkanes, volatile fluorocarbons and chlorofluorocarbons, liquid carbon dioxide under pressure, and combinations thereof. The reverse microemulsion can be an optically clear solution.Type: ApplicationFiled: October 21, 2013Publication date: May 8, 2014Applicant: ROCHAL INDUSTRIES, LLPInventors: Joseph Charles Salamone, Xiaoyu Chen, Ann Beal Salamone, Katelyn Elizabeth Reilly
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Patent number: 8715724Abstract: A process for producing a compressed solid dosage form containing an active ingredient. The process includes a step of preparing core elements containing the active ingredient. Optionally the core elements are coated with a pharmaceutically acceptable coating layer to form coated pellets. The core elements or pellets are treated with an anti-static agent and compressed with suitable excipients to form the compressed solid dosage form. Preferred anti static agents are starch, microcrystalline cellulose, kaolin, bentonite, silicates, silicon dioxide, cellulose, stearic acid, sodium stearyl fumarate and glyceryl behenate.Type: GrantFiled: October 28, 2005Date of Patent: May 6, 2014Assignee: Mayne Pharma International Pty LtdInventor: Stefan Lukas
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Publication number: 20140121286Abstract: Esters of 2-propylheptanol with linear or branched, saturated or unsaturated C5-C36 carboxylic acids and C4-C36 dicarboxylic acids, compositions comprising these esters, and to the use of esters of 2-propylheptanol with linear or branched, saturated or unsaturated C5-C36-carboxylic acids and/or C4-C36-dicarboxylic acids in cosmetic and/or topical pharmaceutical preparations.Type: ApplicationFiled: January 7, 2014Publication date: May 1, 2014Applicant: Cognis IP Management GmbHInventors: Markus Dierker, Catherine Weichold, Stefanie Althaus, Lars Zander, Daniela Prinz
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Publication number: 20140112960Abstract: This disclosure provides compositions comprising a visible light-curable mixture capable of forming a biocompatible hydrogel, hydrogels prepared from the hydrogel precursor mixtures, and a biocompatible delivery system comprising a hydrogel. The disclosure also provides a process for preparing a multi layer hydrogel delivery system.Type: ApplicationFiled: October 24, 2013Publication date: April 24, 2014Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventor: Chien-Chi LIN
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Patent number: 8691748Abstract: The disclosure relates generally to materials that comprise organic frameworks. The disclosure also relates to materials that are useful to store and separate biological agents that are environmentally friendly and biocompatible.Type: GrantFiled: September 25, 2008Date of Patent: April 8, 2014Assignee: The Regents of the University of CaliforniaInventors: Omar M. Yaghi, Oussama M. El-Kadri, Qianrong Fang, Qiaowei Li
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Publication number: 20140094399Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.Type: ApplicationFiled: September 17, 2013Publication date: April 3, 2014Applicant: Massachusetts Institute of TechnologyInventors: Robert S. Langer, David M. Lynn, David A. Putnam, Mansoor M. Amiji, Daniel Griffith Anderson
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Publication number: 20140094527Abstract: Methods for extracting an extract of volatile odorous compounds from an organic raw material containing odorous compounds is disclosed. The method includes contacting an organic raw material with dimethyl carbonate, as a solvent, in at least one bath at a temperature of 10° C. to 70° C. A liquid organic phase is obtained that includes the dimethyl carbonate charged with volatile odorous compounds and is collected. If the liquid organic phase comprises an immiscible aqueous phase, decanting occurs to separate the dimethyl carbonate charged with odorous compounds therefrom thereby eliminating the aqueous phase. Next, partially eliminating by evaporation forms a pre-concentrated extract of volatile odorous compounds, which is recovered and if water is present, decanting occurs to eliminate the water. Additionally, concentrating the pre-concentrated extract of volatile odorous compounds by evaporation is performed to obtain the extract of volatile odorous compounds.Type: ApplicationFiled: April 6, 2012Publication date: April 3, 2014Applicant: CHARABOTInventor: Sophie Lavoine-Hanneguelle
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Publication number: 20140086992Abstract: Described is a storage-stable dust-free homogeneous particulate formulation. The formulation consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives. The sum of (a), (b), (c) and (d) equals 100% by weight of the formulation. The fines fraction with particle diameters of less than 100 ?m is less than 10% by weight. Describe also is a process for manufacturing the formulation, and use of the formulation as a solubilizing composition in pharmaceutical formulations.Type: ApplicationFiled: September 25, 2013Publication date: March 27, 2014Applicant: BASF SEInventors: Felicitas Guth, Karl Kolter, Michael Schönherr, Michael Klemens Müller
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Patent number: 8680011Abstract: This invention relates to an improved granular formulation of herbicide glyphosate in form of ammonium salt using environmentally friendly adjuvants, and a process for preparation thereof. The formulation minimizes the use of some inactive ingredients without compromising the effectiveness of the product.Type: GrantFiled: October 3, 2008Date of Patent: March 25, 2014Assignees: Excel Crop Care Limited, C C Shiroff Research InstituteInventors: Dipesh Kantisen Shroff, Ashwin Champraj Shroff, Ashok Kundanmal Jain, Rajendra Pralhad Chaudhari, Sanjay Dhirajlal Vadodaria, Sanjay Shambhubhai Vaghela, Vandana Chandrakant Mhatre, Bhakti Rajesh Thakkar
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Publication number: 20140080924Abstract: A self-emulsifying and stabilizing gel is disclosed for stabilizing a water-in-oil emulsion or an anhydrous cosmetic to prevent decomposition of said cosmetic compositions, which consists essentially of a shear mixture of: (i) 2 to 30% by weight of a quaternized clay and a first non-polar organic solvent forming a shear mixture as a first phase; and (ii) 2 to 50% by weight of a polymeric emulsifier having a hydrophilic/lipophilic balance under 12 in admixture with a second non-polar organic solvent which may be the same or different from the first non-polar organic solvent as a second phase, wherein said polymeric emulsifier serves as a polar activator of the quaternized clay. Preferred polymeric emulsifiers include a polyglyceryl ether or ester or a silicone emulsifier.Type: ApplicationFiled: September 13, 2013Publication date: March 20, 2014Inventor: Richard T. RIGG
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Publication number: 20140079780Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.Type: ApplicationFiled: November 19, 2013Publication date: March 20, 2014Applicant: GRUENENTHAL GMBHInventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
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Patent number: 8673816Abstract: Surfactant compounds which include an amine ended polyalkylene glycol hydrophile linked to C22 to C60 mainly hydrocarbyl, particularly composite hydrocarbyl, especially derived from a polymerised fatty acid and/or an aralkyl substituted phenol, hydrophobe, are useful in dispersing solids, particularly active agrochemicals, in aqueous media, or as adjuvants in agrochemical formulations, particularly of water soluble non-selective herbicides. In particular the hydrophobe is derived from polymerised fatty acids, such as dimer and, especially, trimer acids or from aralkyl substituted phenols. Aqueous dispersions using such surfactants can remain stable even with substantial concentrations of electrolyte e.g. in stable agrochemical dispersions including water soluble electrolyte agrochemical, such as glyphosate and/or ammonium sulphate.Type: GrantFiled: May 5, 2010Date of Patent: March 18, 2014Assignees: Croda, Inc., Croda International PLCInventors: Trevor Graham Blease, Gregory James Lindner, Lee David Richards
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Patent number: 8673987Abstract: A surfactant composition contains at least one sorbitan ester and at least one sorbitol ester wherein the mean number of carbon atoms of the hydrophobe of the sorbitan ester is greater than that of the sorbitol ester. The surfactant composition is particularly suitable for use in stabilizing emulsions, especially personal care or cosmetic products.Type: GrantFiled: April 12, 2005Date of Patent: March 18, 2014Assignee: Croda International PLCInventors: Hanamanthsa S Bevinakatti, Christian J Dederen, Caroline L Kelly, Stuart Jackson
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Publication number: 20140072639Abstract: Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.Type: ApplicationFiled: November 12, 2013Publication date: March 13, 2014Applicant: Dermazone Solutions, Inc.Inventor: Michael W. Fountain
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Publication number: 20140073502Abstract: A stabilized oil-in-water seed treatment formulation having superior handling characteristics.Type: ApplicationFiled: March 9, 2012Publication date: March 13, 2014Applicant: SYNGENTA PARTICIPATIONS AGInventors: Charles Jones, Carolyn Moore, Andrew Pearson
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Publication number: 20140073707Abstract: Compositions comprising a fluorosurtactant and a fluoro-free hydrotrope are disclosed. The fluoro-free hydrotropes are cationic aromatic compounds, anionic aromatic compounds, or water soluble azo derivatives.Type: ApplicationFiled: September 13, 2012Publication date: March 13, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Thomas G. Calvarese, Weiming Qiu, Anilkumar Raghavanpillai, Yamaira Gonzalez
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Publication number: 20140066364Abstract: A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.Type: ApplicationFiled: November 8, 2013Publication date: March 6, 2014Applicant: Adhezion Biomedical, LLCInventors: Jeoung Soo Lee, Charles Kenneth Webb, Robert Zimmerman, Rafael Ruiz, SR.
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Publication number: 20140065081Abstract: The present invention relates to a class of fragrance precursor compounds comprising one or more of the compounds derived from the reaction of X—OH and an aldehyde or ketone, said fragrance precursor compounds being of the formula X—O—C(R)(R*)(OR**) wherein R is a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R* is H or a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R** is H or X; X—O representing a moiety derived from X—OH, and wherein X—OH is a compound selected from the group consisting of surfactants, fabric softeners, softener precursor ester amines, softener precursor amido amines, hair conditioners, skin conditions, saccharides and polymers. In a second aspect it relates to a method of preparing such precursors. Further the invention relates to compositions, comprising the precursor of the invention.Type: ApplicationFiled: September 23, 2013Publication date: March 6, 2014Applicant: Colgate-Palmolive CompanyInventors: Daniel W. Smith, Amjad Farooq, Donghui Wu, Marija Heibel, Karen Drehs
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Publication number: 20140057956Abstract: The invention relates to a copolymer having a backbone that is obtained by radical polymerisation of: a fatty body (A) comprising unsaturations and/or hydroxyl functions; and at least one monomer (B) including at least one function that can be polymerised by means of radical polymerisation and comprising either (i) at least one linear or branched alkyl chain having preferably between 16 and 44 carbon atoms, and more preferably at least 18 carbon atoms, e.g. at least 20 carbon atoms, in particular 22 carbon atoms or 44 carbon atoms, or (ii) a reactive function. The invention also relates to a method for modifying the rheological properties of an non-aqueous medium with the addition of a copolymer of the invention. The invention further relates to a composition formed totally or partially by a copolymer of the invention. Preferably, the composition is an emulsifiable composition. Furthermore, the invention relates to a composition comprising a copolymer of the invention and an emulsifying agent.Type: ApplicationFiled: April 27, 2012Publication date: February 27, 2014Applicant: RHODIA OPERATIONSInventors: Marc Balastre, Chi-Thanh Vuong
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Publication number: 20140056832Abstract: The present invention relates to the use of at least one 2-methylsuccinic acid diester derivative of formula (I), in a composition comprising, in a cosmetically acceptable medium, at least one liquid fatty phase and at least one lipophilic active agent, for dissolving the said active agent in the said liquid fatty phase and/or for improving the solubility of the said active agent in the said solid fatty phase. The present invention relates especially to a composition comprising, in a cosmetically acceptable medium, at least one liquid fatty phase, characterized in that it contains at least one 2-methylsuccinic acid ester derivative of formula (I) and at least one lipophilic active agent.Type: ApplicationFiled: February 23, 2012Publication date: February 27, 2014Inventors: Herve Richard, Benoit Muller
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Publication number: 20140044654Abstract: The present disclosure relates, according to some embodiments, to molecules, including conjugated fused polycyclic molecules, that may receive excited state energy from other molecules (e.g., light-absorbing molecules) or directly from the irradiation sources. According to some embodiments, the disclosure relates to molecules, including conjugated fused polycyclic molecules, that may resolve (e.g., quench, dissipate) excited state energy, normally by way of releasing it as heat. (e.g., as heat). Conjugated fused polycyclic molecules of various structures are disclosed including Formula III: The disclosure further relates to methods of use and/or therapy using molecules of Formulas I, II, and/or III.Type: ApplicationFiled: August 9, 2013Publication date: February 13, 2014Applicant: HALLSTAR INNOVATIONS CORP.Inventors: Craig A. Bonda, Shengkui Hu, Qing Jean Zhang, Zhihui Zhang
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Publication number: 20140045913Abstract: The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X3 is absent or is alkyl, etc, X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and Y1 is absent or anion, L1 is a single bond, etc, R3 is alkyl, etc), and a cationic lipid represented by formula (II) (wherein: R4 and R5 are, the same or different, alkenyl, etc, and X4 and X5 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X6 is absent or is alkyl, etc, Y2 is absent or anion, a and b are, the same or different, 0 to 3, and L4 is a single bond, etc, R6 is alkyl, etc, L2 and L3 are —O—, —CO—O— or —O—CO—), and the like.Type: ApplicationFiled: December 12, 2012Publication date: February 13, 2014Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI
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Publication number: 20140045693Abstract: The invention relates to a wetting composition comprising greater than or equal to about 50 wt % of a C5 to C12 alcohol; and a surfactant, methods for using the wetting composition and products containing the wetting composition.Type: ApplicationFiled: April 2, 2012Publication date: February 13, 2014Applicant: RJ ROBERTS CONSULTING PTY LTDInventor: Raymond John Roberts
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Publication number: 20140037711Abstract: The instant invention relates to a composition comprising at least one polymer having the structure A-B-A?, wherein A and A? may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A?. Additionally, the invention also relates to the development of a bioresorbable patch comprising: (a) an adhesion barrier component comprising a composition according to the invention in the form of a film; and (b) an adhesive component comprising: (i) at least one synthetic adhesive polymer; and/or (ii) at least one polysaccharide. The present invention provides a method of wound healing, comprising administering the composition or patch.Type: ApplicationFiled: October 20, 2011Publication date: February 6, 2014Applicant: DSM IP ASSETS B.V.Inventors: James Parakka, Ananth Iyer
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Publication number: 20140039071Abstract: The invention provides the esters of a mixture of 2-methyl-1-butanol and 3-methyl-1-butanol and the use thereof for producing formulations.Type: ApplicationFiled: March 27, 2012Publication date: February 6, 2014Applicant: EVONIK DEGUSSA GMBHInventors: Oliver Thum, Marrit Friederike Eckstein, Oliver Springer, Susann Wiechers, Juergen Meyer
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Patent number: 8642666Abstract: An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.Type: GrantFiled: June 24, 2009Date of Patent: February 4, 2014Assignee: Protherics Salt Lake City, Inc.Inventors: Chung Shih, Gaylen M. Zentner
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Patent number: 8637085Abstract: An aqueous disinfecting solution having a pH from about 0.5 to about 6 and consisting essentially of hydrogen peroxide in a concentration from about 0.05 to about 8 w/w % of the total solution; at least one anionic surfactant in a concentration from about 0.02 to about 8 w/w % of the total solution, selected from sulfonated C12 to C22 carboxylic acids and alkali metal, ammonium, calcium and magnesium salts thereof; naphthalene sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; C8 to C22 alkyl sulfonic acids and alkali metal, ammonium, calcium and magnesium salts thereof; and alkyl or alkenyl esters or diesters of sulfosuccinic acids in which the alkyl or alkenyl groups independently contain from six to eighteen carbon atoms and alkali metal, ammonium, calcium and magnesium salts thereof; and benzyl alcohol in a concentration from about 0.1 to about 10 w/w % of the solution.Type: GrantFiled: March 21, 2012Date of Patent: January 28, 2014Assignee: Virox Technologies Inc.Inventors: Jose A. Ramirez, Navid Omidbakhsh
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Publication number: 20140023697Abstract: In one aspect, embodiments of the invention provide a method, the method comprising contacting at least one osmotic body and a droplet comprising solvent and at least one solute. The contacting forms at least one thin film between the droplet and the at least one osmotic body. The method further comprises allowing solvent to transfer between the droplet and the at least one osmotic body, to form a precipitate of the at least one solute.Type: ApplicationFiled: May 17, 2013Publication date: January 23, 2014Applicant: IONA COLLEGEInventor: SUNGHEE LEE DIMAURO
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Publication number: 20140023598Abstract: The present invention relates to a class of fragrance precursor compounds comprising one or more of the compounds derived from the reaction of X—OH and an aldehyde or ketone, said fragrance precursor compounds being of the formula X—O—C(R)(R*)(OR**) wherein R is a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R* is H or a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R** is H or X; X—O representing a moiety derived from X—OH, and wherein X—OH is a compound selected from the group consisting of surfactants, fabric softeners, softener precursor ester amines, softener precursor amido amines, hair conditioners, skin conditions, saccharides and polymers. In a second aspect it relates to a method of preparing such precusors. Further the invention relates to compositions, comprising the precursor of the invention.Type: ApplicationFiled: September 23, 2013Publication date: January 23, 2014Applicant: Colgate-Palmolive CompanyInventors: Daniel W. Smith, Amjad Farooq, Donghui Wu, Marija Heibel, Karen Drehs
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Publication number: 20140017322Abstract: Disclosed are nanoparticles, such as carbon nanotubes or other graphitic sheet materials having extended aromatic surfaces, which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a “drug”) to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer or adsorption of an amphiphilic molecule to render them stable in suspension. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker.Type: ApplicationFiled: September 16, 2013Publication date: January 16, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Hongjie Dai, Zhuang Liu, Xiaolin Li, Xiaoming Sun
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Publication number: 20140018444Abstract: The present invention provides a water-in-oil emulsion cosmetic that is excellent in the resilient and supple (in other words, firm and tensional) feels and also excellent in the moisturizing effect and feeling in use. The water-in-oil emulsion cosmetic of the present invention is characterized by comprising the following (A) to (D): (A) 0.5 to 10 mass % of bis-diglyceryl polyacyladipate-2 (B) an oil containing (b1) (b1) a volatile oil of low compatibility with (A) (C) an emulsifying agent and (D) 60 to 90 mass % of an aqueous component, wherein the percentage of component (b1) is 40 to 85% with respect to component (A) and component (B).Type: ApplicationFiled: March 29, 2012Publication date: January 16, 2014Applicant: SHISEIDO COMPANY, LTD.Inventors: Masaki Kitajima, Ayako Abe, Kei Watanabe, Takayuki Omura
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Publication number: 20140018443Abstract: The present invention is to provide a vesicle composition comprising the following components (A), (B) and (C): (A) 0.0001 to 20 mass % of an organic acid represented by general formula (1): wherein R1 represents a natural sterin having a single hydroxy group or a hydrogenated product thereof or a residue which remains after a hydrogen atom is removed from the hydroxy group of bile acid, R2 represents a divalent hydrocarbon group having 1 to 24 carbon atoms, M represents a hydrogen atom, an alkali metal, an alkali earth metal, ammonium, an alkanolammonium having 2 to 9 carbon atoms in total, an alkylammonium or alkenylammonium having 1 to 22 carbon atoms in total, pyridinium substituted with an alkyl group or alkenyl group having 1 to 18 carbon atoms or a basic amino acid, (B) 0.0001 to 10 mass % of a sphingosine, and (C) water, and having a pH of 2 to 11.Type: ApplicationFiled: March 30, 2012Publication date: January 16, 2014Applicant: KAO CORPORATIONInventor: Yumiko Yamamoto
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Patent number: 8628760Abstract: A personal care composition comprising: a near-terminal branched compound according to Formula I; a cosmetically acceptable aqueous carrier; wherein the near-terminal branched compound is not comprised in a gel network.Type: GrantFiled: July 14, 2011Date of Patent: January 14, 2014Assignee: The Procter & Gamble CompanyInventors: John David Carter, Elaine Marie Burt, Jeffrey John Scheibel, David Johnathan Kitko, Jun Xu, Charles Winston Saunders, Kenneth Nathan Price, Stephanie Ann Urbin, Phillip Richard Green
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Publication number: 20140010949Abstract: Coatings for medical devices, methods of making the coatings, and methods of using them are described.Type: ApplicationFiled: July 16, 2013Publication date: January 9, 2014Inventors: Keith M. Faucher, Hui Tang, Lisa Rogers, Joseph Ferraro, Paul Martakos, Steven A. Herweck, Theodore Karwoski
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Publication number: 20140004199Abstract: The present invention discloses a drug carrier with the capability of systemic administration through intravenous injection, its preparation methods and it is used for tumor gene therapy, it is belong to the field of tumor-targeted therapy. The carrier of the present invention is a novel liposome which is composed of DOTAP or its analogue and lecithin or its derivative in molar ratio of 20:(7-13), it can form stable complex with bioactive materials, and can deliver these bioactive material to the targeted cells cultured in vitro or in vivo. The complex of the present invention has a larger packaging capability, and the particle size is greatly reduced, that is optimized to 200 nm and below, in an environment of high serum concentration, it maintains high transfection efficiency. The carrier of the present invention packages DNA of tumor suppressor genes or cell suicide gene by forming complexes which can be specifically delivered into tumor cells in vitro, ex vivo or in vivo for gene therapeutic purposes.Type: ApplicationFiled: March 21, 2012Publication date: January 2, 2014Applicant: CHENGDU NUOEN BIOTECHNOLY CO., LTDInventor: Hong Xiao
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Publication number: 20140005135Abstract: Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 ?l to 3 ml.Type: ApplicationFiled: March 14, 2013Publication date: January 2, 2014Applicant: XERIS PHARMACEUTICALS, INC.Inventors: Steven J. Prestrelski, Nancy Scott
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Publication number: 20130336902Abstract: A personal care composition is disclosed comprising a di-amido gellant, wherein the di-amido gellant has a formula: wherein R1 and R2 are aminofunctional end-groups which may be the same or different, and L is a linking moiety of molecular weight from 14 to 500 g/mol. The personal care composition may take a variety of forms such as a leave-on composition or an emulsion and/or may comprise one or more actives or agents.Type: ApplicationFiled: June 13, 2012Publication date: December 19, 2013Inventors: SUSANA FERNANDEZ PRIETO, JOHAN SMETS, BEATRIU ESCUDER GIL, JUAN FELIPE MIRAVET CELADES, VICENT JOSEP NEBOT CARDA, PAUL ROBERT TANNER