Nitrogen Containing Patents (Class 514/788)
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Patent number: 8841382Abstract: The present invention provides an amphiphile of the formula (I) as described hereinafter. The invention further relates to a process for preparing the amphiphile and to a composition comprising the amphiphile and a sparingly water-soluble active ingredient. It further relates to a process for producing the composition by contacting the amphiphile and the active ingredient, and to the use of the amphiphile for solubilizing a sparingly water-soluble active ingredient in aqueous solutions. The invention also relates to the use of the amphiphile in an agrochemical formulation comprising the amphiphile and a pesticide for controlling phytopathogenic fungi and/or unwanted vegetation and/or unwanted insect or mite infestation and/or for regulating the growth of plants, and finally to plant propagation material comprising the amphiphile.Type: GrantFiled: August 31, 2011Date of Patent: September 23, 2014Assignee: BASF SEInventors: Anna Cristadoro, Holger Türk, Michael Ishaque, Rabie Al-Hellani
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Publication number: 20140271956Abstract: The present invention relates to a lamellar structure which stabilizes oil and to a cleansing composition comprising the lamellar structure. More particularly, the present invention relates to a lamellar structure, which stabilizes oil to be used in a cleansing composition so that high-content oil is converted to a lamellar phase and contained in a composition. The present invention also relates to a cleansing composition which comprises the lamellar structure which enables the composition to contain high-content oil in a stable manner and to thus provide superior moisturizing ability.Type: ApplicationFiled: October 8, 2012Publication date: September 18, 2014Inventors: Chang Jo Jung, Dae Kyeong Kim, John Hwan Lee, Wang Gi Kim
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Publication number: 20140255373Abstract: The present invention relates to an alpha-alkoxysilane-terminated prepolymer preparable by reaction of at least one polyether polyol, of a polyisocyanate and of an alpha-alkoxysilane having at least one isocyanate-reactive group, said polyether polyol having a weight average of 500 to 7000 g/mol and having ethylene oxide and propylene oxide units, the proportion of ethylene oxide units being up to 50% by weight based on the polyether polyol. The invention further provides a process for preparing an inventive alpha-alkoxysilane-terminated prepolymer, a composition, a multicomponent system and a spray can comprising an inventive alpha-alkoxysilane-terminated prepolymer, and also a moulding obtainable by polymerization from an inventive alpha-alkoxysilane-terminated prepolymer.Type: ApplicationFiled: September 25, 2012Publication date: September 11, 2014Applicant: Bayer Intellectual Property GmbHInventor: Jan Schönberger
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Publication number: 20140242123Abstract: The disclosure provides for saccharide-peptide based hydrogels, the functionalization of the saccharide-peptide based hydrogels with one or more biological agents, and the encapsulation of one or more biological materials and/or pharmaceutical agents in the hydrogels. The disclosure further provides for the use of the saccharide-peptide based hydrogels in treating a disease or disorder in a subject.Type: ApplicationFiled: February 21, 2014Publication date: August 28, 2014Inventors: Zhibin Guan, Yoko Mullen, Sophia W. Liao
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Patent number: 8815956Abstract: The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.Type: GrantFiled: August 10, 2012Date of Patent: August 26, 2014Assignee: Senomyx, Inc.Inventors: Catherine Tachdjian, Xiao-Qing Tang, Donald S. Karanewsky, Guy Servant, Xiaodong Li, Feng Zhang, Qing Chen, Hong Zhang, Timothy James Davis, Vincent Darmohusodo, Melissa Sue Wong, Victor Selchau
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Publication number: 20140221211Abstract: One subject of the present invention is the use, as solvents, of compounds of esteramide type. Another subject of the invention are particularly practical processes for preparing esteramides. Another subject of the invention are novel esteramides, which may in particular be used as solvents, for example in phytosanitary formulations.Type: ApplicationFiled: April 9, 2014Publication date: August 7, 2014Applicant: RHODIA OPERATIONSInventors: Olivier JENTZER, Massimo GUGLIERI
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Publication number: 20140219930Abstract: The following invention relates to a taste enhancer and a method of enhancing taste. The invention relates the use of a cooling enhancing composition which provides cooling enhancement when combined with other cooling compounds.Type: ApplicationFiled: December 21, 2012Publication date: August 7, 2014Applicant: International Flavors & Fragrances Inc.Inventors: Thumpalasseril V. John, Mark L. Dewis, Kathryn Bardsley, Kenneth J. Kraut, Hou Wu
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Publication number: 20140213666Abstract: The invention relates to a reaction product of a polar modified polymer and an alkoxysilane having at least one solubilizing functional group and at least one amino substituent.Type: ApplicationFiled: March 27, 2014Publication date: July 31, 2014Applicant: L'OrealInventors: Hy Si BUI, Anita Chon TONG, Maria Pia ROSSI
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Patent number: 8791145Abstract: The present invention provides a formulation comprising a pesticide and/or a plant growth regulator; an acyl morpholine of the formula (I) where R is H, CH3 or C2H5; and a polar aprotic co-solvent different from an acyl morpholine of formula (I). The formulation can be used in treatment of plants, and is especially well suited for use as a soluble liquid formulation.Type: GrantFiled: May 24, 2011Date of Patent: July 29, 2014Assignee: Akzo Nobel Chemicals International B.V.Inventor: Peter Westbye
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Publication number: 20140200257Abstract: The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.Type: ApplicationFiled: January 11, 2012Publication date: July 17, 2014Applicant: ALNYLAM PHARMACEUTICALS, INC.Inventors: Kallanthottathil G Rajeev, Muthiah Manoharan, Muthusamy Jayaraman, Martin Maier, Jayaprakash K. Nair, David Butler
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Patent number: 8778319Abstract: The invention relates to novel polysiloxanes having quaternary ammonium groups, and to a method for producing same. The invention further relates to the use of said polymers as an active care ingredient in formulations for the care and cleansing of skin and skin appendages, for example, as conditioning agents for hair.Type: GrantFiled: December 17, 2010Date of Patent: July 15, 2014Assignee: Evonik Degussa GmbHInventors: Sascha Herrwerth, Christian Hartung, Patrick Winter, Michael Ferenz, Frauke Henning
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Publication number: 20140194537Abstract: The present invention relates to a method for producing an additive composition which in particular contains specific urea urethanes. The additive composition is extremely suitable as a wetting agent and dispersant.Type: ApplicationFiled: May 5, 2012Publication date: July 10, 2014Applicant: BYK-CHEMIE GMBHInventors: Bernd Göbelt, René Nagelsdiek, Jürgen Omeis, Frederik Piestert, Wolfgang Pritschins, Natasa Meznaric, Daniela Schröder, Werner Tiegs
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Publication number: 20140187614Abstract: The present invention provides new amino lipids and a convenient method for synthesising these compounds. These (cationic) amino lipids have good properties as transfection agents. The method is an economic versatile two step synthesis allowing the preparation of various amino lipids thus leading to the assembly of a combinatorial library of transfection agents. Moreover, the present invention provides lipid particles (liposomes) containing said amino lipids and their use for delivering bioactive agents into cells. The invention encompasses also the use of lipid particles containing the cationic amino lipids as medicament.Type: ApplicationFiled: May 15, 2012Publication date: July 3, 2014Applicant: INCELLA GMBHInventors: Gary Davidson, Pavel Levkin, Linxian Li, Yi Su, David Zahner
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Publication number: 20140162934Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.Type: ApplicationFiled: February 12, 2014Publication date: June 12, 2014Applicant: AXOLABS GMBHInventors: Rainer CONSTIEN, Anke Geick, Philipp Hadwiger, Torsten Haneke, Ludger Markus Ickenstein, Carla Alexandra Hernandez Prata, Andrea Schuster, Timo Weide
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Publication number: 20140142166Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.Type: ApplicationFiled: November 5, 2013Publication date: May 22, 2014Applicant: SurModics, Inc.Inventors: Joseph Ventura, Shannon Wadman, Joram Slager, Joseph Schmidt McGonigle, Robert W. Hergenrother
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Publication number: 20140134125Abstract: The invention relates to microemulsions which comprise, as oil phase, a polysiloxane containing at least one quaternary ammonium group, methods for production thereof and also to the use of such microemulsions.Type: ApplicationFiled: March 19, 2012Publication date: May 15, 2014Applicant: EVONIK DEGUSSA GMBHInventors: Verena Dahl, Sascha Herrwerth, Christian Hartung, Joachim Venzmer, Dirk Kuppert, Berend-Jan De Gans
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Publication number: 20140134260Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid in vivo. The compositions of the present invention are highly potent, thereby allowing effective know-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.Type: ApplicationFiled: October 1, 2013Publication date: May 15, 2014Applicant: Protiva Biotherapeutics, Inc.Inventors: James Heyes, Lorne Palmer, Magdalena Maslowski, Ian MacLachlan
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Publication number: 20140128482Abstract: The present invention relates to improved hydrogel materials using water gellants that are comprised of polymer backbones P to which hydrogen bonding 4H-units are covalently attached via a hydrophobic linker L. Optionally, the hydrogel contains additional ingredients or additives. These new reversible hydrogels can easily be fine-tuned in their mechanical performance and function and are especially suitable for biomedical applications.Type: ApplicationFiled: January 10, 2014Publication date: May 8, 2014Applicant: SupraPolix B.V.Inventors: Travis Wayne BAUGHMAN, Gaby Maria Leonarda Van Gemert, Henricus Marie Janssen, Egbert Willem Meijer, Anton Willem Bosman
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Patent number: 8709452Abstract: The disclosure provides bone-mimetic mineral/polymer composite materials useful for formation of artificial bone grafts and for bone tissue engineering. The disclosure provides a hydrogels, cryogels and macroporous compositions modified with varying lengths of anionic pendant side chains (CH2?CHCONH(CH2)nCOOH, where n=1 to 12).Type: GrantFiled: July 13, 2012Date of Patent: April 29, 2014Assignee: The Regents of the University of CaliforniaInventors: Shyni Varghese, Ameya Phadke
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Publication number: 20140107047Abstract: Aqueous compositions comprising a) at least one active compound and b) at least one hydrotrope in an amount effective to increase transdermal penetration of the active compound, and methods for increasing bioavailability of active compounds are provided.Type: ApplicationFiled: October 12, 2012Publication date: April 17, 2014Applicant: L'Oreal S.A.Inventors: Elizabeth Hunter Lauten, Jean-Thierry Simonnet, Zhi Pan, Guive Balooch
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Publication number: 20140094529Abstract: Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.Type: ApplicationFiled: October 13, 2011Publication date: April 3, 2014Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARKInventors: Lyle David Isaacs, Volker Briken, Gaya Hettiarachchi, Da Ma, Duc M. Nguyen
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Patent number: 8686154Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: GrantFiled: June 10, 2009Date of Patent: April 1, 2014Assignee: Emisphere Technologies, Inc.Inventors: Donald J. Sarubbi, Eugene N. Barantsevitch
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Publication number: 20140088166Abstract: In its several embodiments, this invention discloses a pharmaceutical formulation comprising at least one antineoplastic agent or a pharmaceutically acceptable salt thereof, and at least one dissolution enhancing agent sufficient to substantially dissolve said at least one antineoplastic agent in at least one aqueous diluent, wherein said dissolution enhancing agent is urea, L-histidine, L-threonine, L-asparagine, L-serine, L-glutamine or mixtures thereof; a lyophilized powder comprising said pharmaceutical formulation, and articles of manufacture thereof.Type: ApplicationFiled: December 2, 2013Publication date: March 27, 2014Inventors: Sydney Ugwu, Vinay Radhakrishnan, Peter M. Ihnat, Lenore C. Witchey-Lakshmanan
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Publication number: 20140080924Abstract: A self-emulsifying and stabilizing gel is disclosed for stabilizing a water-in-oil emulsion or an anhydrous cosmetic to prevent decomposition of said cosmetic compositions, which consists essentially of a shear mixture of: (i) 2 to 30% by weight of a quaternized clay and a first non-polar organic solvent forming a shear mixture as a first phase; and (ii) 2 to 50% by weight of a polymeric emulsifier having a hydrophilic/lipophilic balance under 12 in admixture with a second non-polar organic solvent which may be the same or different from the first non-polar organic solvent as a second phase, wherein said polymeric emulsifier serves as a polar activator of the quaternized clay. Preferred polymeric emulsifiers include a polyglyceryl ether or ester or a silicone emulsifier.Type: ApplicationFiled: September 13, 2013Publication date: March 20, 2014Inventor: Richard T. RIGG
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Publication number: 20140073707Abstract: Compositions comprising a fluorosurtactant and a fluoro-free hydrotrope are disclosed. The fluoro-free hydrotropes are cationic aromatic compounds, anionic aromatic compounds, or water soluble azo derivatives.Type: ApplicationFiled: September 13, 2012Publication date: March 13, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Thomas G. Calvarese, Weiming Qiu, Anilkumar Raghavanpillai, Yamaira Gonzalez
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Publication number: 20140066511Abstract: A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as promoting hair growth on scalp tissue lacking sufficient hair, restoring normal sexual function in males with erectile dysfunction. Specifically, this is a preparation which provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the scalp or penis. The preparation also contains an agent which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of choline chloride, magnesium chloride and sodium chloride.Type: ApplicationFiled: October 30, 2013Publication date: March 6, 2014Applicant: Strategic Science & Technologies, LLCInventor: Eric T. Fossel
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Publication number: 20140045698Abstract: Described is a class of symmetrical and asymmetrical N-alkyl lactam ethers. One preferred ether is bis-N-ethyl pyrrolidone ether. Preferred compositions and uses of the ethers are in performance chemicals, personal care, and pharmaceutical fields, where they function a variety of roles, including as a solvent, solubilizer, freezing point depressor, diluent, extracting agent, cleaning agent, degreaser, absorbent and/or dispersion agent.Type: ApplicationFiled: October 18, 2013Publication date: February 13, 2014Applicant: ISP INVESTMENTS INC.Inventors: Osama M. Musa, Kolazi S. Narayanan
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Publication number: 20140045913Abstract: The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl, etc, and X3 is absent or is alkyl, etc, X1 and X2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and Y1 is absent or anion, L1 is a single bond, etc, R3 is alkyl, etc), and a cationic lipid represented by formula (II) (wherein: R4 and R5 are, the same or different, alkenyl, etc, and X4 and X5 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X6 is absent or is alkyl, etc, Y2 is absent or anion, a and b are, the same or different, 0 to 3, and L4 is a single bond, etc, R6 is alkyl, etc, L2 and L3 are —O—, —CO—O— or —O—CO—), and the like.Type: ApplicationFiled: December 12, 2012Publication date: February 13, 2014Applicant: KYOWA HAKKO KIRIN CO., LTD.Inventors: Takeshi KUBOYAMA, Tomohiro ERA, Tomoyuki NAOI
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Publication number: 20140030208Abstract: Described are novel monocationic polyhydroxyl compounds and their uses in personal care compositions.Type: ApplicationFiled: April 20, 2012Publication date: January 30, 2014Applicant: DOW GLOBAL TECHNOLOGIES LLCInventors: Joseph L. Deavenport, Nicole A. Brehm
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Publication number: 20140023615Abstract: The present invention provides thermo-sensitive, mucoadhesive biopolymer formulations that enhance the penetration of therapeutics across the skin or mucosal surfaces. In a preferred embodiment, the biopolymer formulation comprises co-polymer of poloxamer 188 and propylene glycol, laurocapram and, optionally, one or more therapeutic agents. Also provided are uses of the biopolymer formulations for topical therapy of cancer including cervical cancer.Type: ApplicationFiled: March 29, 2012Publication date: January 23, 2014Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventor: Stephen I-Hong Hsu
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Publication number: 20140023598Abstract: The present invention relates to a class of fragrance precursor compounds comprising one or more of the compounds derived from the reaction of X—OH and an aldehyde or ketone, said fragrance precursor compounds being of the formula X—O—C(R)(R*)(OR**) wherein R is a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R* is H or a C6-24 alkyl group, a C6-24 aralkyl group or a C6-24 alkaryl group; R** is H or X; X—O representing a moiety derived from X—OH, and wherein X—OH is a compound selected from the group consisting of surfactants, fabric softeners, softener precursor ester amines, softener precursor amido amines, hair conditioners, skin conditions, saccharides and polymers. In a second aspect it relates to a method of preparing such precusors. Further the invention relates to compositions, comprising the precursor of the invention.Type: ApplicationFiled: September 23, 2013Publication date: January 23, 2014Applicant: Colgate-Palmolive CompanyInventors: Daniel W. Smith, Amjad Farooq, Donghui Wu, Marija Heibel, Karen Drehs
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Publication number: 20140017322Abstract: Disclosed are nanoparticles, such as carbon nanotubes or other graphitic sheet materials having extended aromatic surfaces, which are used to deliver active agents such as drugs, labels or dyes (termed for convenience a “drug”) to the interior of cells. The nanoparticles are functionalized by a hydrophilic polymer or adsorption of an amphiphilic molecule to render them stable in suspension. The drug is therefore capable of release in the cell exterior. The drug is more rapidly released at lower pH, as found e.g., in tumor cells. The drug may also be linked to a branched chain hydrophilic polymer, so that each polymer molecule carries more than one drug bound by a cleavable linker.Type: ApplicationFiled: September 16, 2013Publication date: January 16, 2014Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Hongjie Dai, Zhuang Liu, Xiaolin Li, Xiaoming Sun
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Patent number: 8629085Abstract: The present invention relates to a composition comprising a) an anionic compound having wetting and dispersing properties selected from the group of a1) an alkyl naphthalene sulfonate, a2) a naphthalene sulfonate-formaldehyde condensate that may optionally be alkyl substituted and mixtures thereof, and b) a nitrogen-containing surfactant selected from the group consisting of alkylamine alkoxylates, alkylamidoamine alkoxylates, alkanolamides and their alkoxylates, alkylamidopropylamines, betaines, amino acids, or any mixtures thereof, wherein the molar amount of anionic sulfonate and, if any are present, carboxylate groups in the composition is in excess of the molar amount of nitrogen-containing groups. These compositions exhibit synergistic wetting properties as compared to the surface-active components taken alone. Further, the compositions also exhibit an increased rainfastness.Type: GrantFiled: September 6, 2012Date of Patent: January 14, 2014Assignee: Akzo Nobel N.V.Inventors: Karin Bergström, Christine Strandberg
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Publication number: 20140005135Abstract: Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 ?l to 3 ml.Type: ApplicationFiled: March 14, 2013Publication date: January 2, 2014Applicant: XERIS PHARMACEUTICALS, INC.Inventors: Steven J. Prestrelski, Nancy Scott
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Patent number: 8618179Abstract: The present invention relates to a composition comprising a pesticide and an alkoxylate. Moreover, the invention relates to the alkoxylate, to a process for its preparation and to its use as adjuvant in pesticide-comprising spray mixtures. The invention furthermore relates to a method of controlling phytopathogenic fungi and/or undesired vegetation and/or undesired insect or mite attack and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, their environment or the plants to be protected from the respective pest, on the soil and/or on undesirable plants and/or the crop plants and/or their environment. Furthermore, the invention relates to seed comprising the composition.Type: GrantFiled: January 14, 2011Date of Patent: December 31, 2013Assignee: BASF SEInventors: Paul Klingelhoefer, Arend Jouke Kingma, Sophie Vogel, Kevin Huyghe, Gerd Haderlein, Gerhard Schnabel, Marc Nolte, Richard Roger Evans
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Publication number: 20130336903Abstract: A personal care composition is disclosed comprising a pH tuneable gellant. The pH tuneable gellant has a formula of: wherein R1 and R2 are aminofunctional end-groups; L1 is a backbone moiety having molecular weight from 14 to 500 g/mol; and at least one of L1, R1 or R2 comprises a pH-sensitive group; wherein R5 is an aminofunctional moiety; L2 is a backbone moiety having molecular weight from 14 to 500 g/mol; and at least one of L2 or R5 comprises a pH-sensitive group; and mixtures of [I] and [II]. The personal care composition may take a variety of forms such as a leave-on composition or an emulsion or may comprise one or more actives or agents.Type: ApplicationFiled: June 13, 2012Publication date: December 19, 2013Inventors: SUSANA FERNANDEZ PRIETO, JOHAN SMETS, BEATRIU ESCUDER GIL, JUAN FELIPE MIRAVET CELADES, VICENT JOSEP NEBOT CARDA, PAUL ROBERT TANNER
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Publication number: 20130336902Abstract: A personal care composition is disclosed comprising a di-amido gellant, wherein the di-amido gellant has a formula: wherein R1 and R2 are aminofunctional end-groups which may be the same or different, and L is a linking moiety of molecular weight from 14 to 500 g/mol. The personal care composition may take a variety of forms such as a leave-on composition or an emulsion and/or may comprise one or more actives or agents.Type: ApplicationFiled: June 13, 2012Publication date: December 19, 2013Inventors: SUSANA FERNANDEZ PRIETO, JOHAN SMETS, BEATRIU ESCUDER GIL, JUAN FELIPE MIRAVET CELADES, VICENT JOSEP NEBOT CARDA, PAUL ROBERT TANNER
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Publication number: 20130338631Abstract: Aspects of the invention relate to an applicator which can house multiple components of a formulation in separate receptacles. In certain embodiments, an applicator of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues.Type: ApplicationFiled: March 14, 2011Publication date: December 19, 2013Applicant: HyperBranch Medical Technology, Inc.Inventors: Jared D. G. Butlin, Keith R. D'Alessio
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Publication number: 20130338210Abstract: A method for delivering a nucleic acid to a cell can include exposing sample cells to a composition which includes charged lipids.Type: ApplicationFiled: December 7, 2010Publication date: December 19, 2013Applicant: ALNYLAM PHARMACEUTICALS, INC.Inventors: Muthiah Manoharan, Khallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Mamta Kapoor, Rajesh Kumar Kainthan
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Publication number: 20130338143Abstract: Disclosed herein are compositions that are useful in effecting the transdermal delivery of therapeutic agents. More particularly, the disclosed transdermal compositions may include a fatty alcohol (for example, octanol), a terpene (for example, limonene), and an active agent comprising an amine moiety.Type: ApplicationFiled: November 15, 2011Publication date: December 19, 2013Applicant: Neuroderm, Ltd.Inventors: Oron Yacoby-Zeevi, Mara Nemas, Eduardo Zawozink
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Publication number: 20130317590Abstract: Stents and delivery systems with reduced chemical degradation and methods of sterilizing the same are disclosed.Type: ApplicationFiled: July 31, 2013Publication date: November 28, 2013Applicant: Abbott Cardiovascular Systems Inc.Inventors: Bin Huang, Lothar W. Kleiner, John Stankus
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Publication number: 20130303580Abstract: Oil-in-water fungicidal formulations are prepared having pigment dispersed therein, the pigment being stable within the oil-in-water emulsion as a result of the addition of suitable silicone surfactants and suitable emulsifiers. The formulations can be prepared either as a 2-pack formulation or as a single formulation. In the case of the single formulation polyethylene glycol is also added. In either case, the formulations show a synergistic effect through the addition of the pigment, the resulting formulations having an increased efficacy. Further, the formulations show a synergistic effect when mixed with conventional chemical fungicides, both being added in reduced amounts compared to recommended rates.Type: ApplicationFiled: March 15, 2013Publication date: November 14, 2013Inventor: Suncor Energy Inc.
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Publication number: 20130295081Abstract: The presently-disclosed subject matter includes polyurethane composites that include tissue component(s), as well as methods of making such composites and uses thereof. The polyurethane component can comprise a polyisocyanate prepolymer and a polyol. The tissue component can be a polysaccharide. Exemplary composites can be moldable and/or injectable, and can cure into a porous composite that provides mechanical strength and/or supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shaped areas, voids, or the like. Exemplary composites can be used for treating wounds.Type: ApplicationFiled: April 16, 2013Publication date: November 7, 2013Inventors: Scott A. Guelcher, Andrea Hafeman, Jeffrey Davidson, Lillian M. Nanney, Elizabeth Adolph
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Patent number: 8569385Abstract: The present invention provides for a composition comprising a silane having the formula: (R1)(R2)(R3)Si—R4—Si(R5)(R6)(R7) wherein R1, R2, R3, R5, and R6 are each independently selected from the group consisting of 1 to 6 monovalent hydrocarbon radicals, aryl, and a hydrocarbon group of 7 to 10 carbons containing an aryl group; R4 is a hydrocarbon group of 1 to 3 carbons; R7 comprises an anionic, cationic or zwitterionic substituent. The silanes of the present invention exhibit resistance to hydrolysis over a wide pH range.Type: GrantFiled: November 29, 2010Date of Patent: October 29, 2013Assignee: Momentive Performance Materials Inc.Inventors: Mark D. Leatherman, George A. Policello, Wenqing N. Peng, Liping Zeng, Ronald Wagner, Suresh K. Rajamaran, Zijun Xia
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Publication number: 20130280304Abstract: The present invention provides an improved method of administering a medicinal, dental or nutritional agent to a non-human animal, such as a domesticated dog or cat. The method comprises mixing a liquid composition in a mixer at various speeds and pressures for a period of time; pouring the liquid composition onto a conveyor belt propelled by polymer rollers, wherein the polymer rollers allow the components to advance on the conveyor belt without adhering to the belt; evenly distributing the composition on the belt with the use of a knife; heating the composition in one or more hot-air chambers; obtaining a film comprised of the composition; cutting the film into strips; and then administering one or more of the strips to the non-human animal by placing the strip under the tongue of the animal, i.e., by sub-lingual administration.Type: ApplicationFiled: October 22, 2012Publication date: October 24, 2013Inventor: Douglas Kramer
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Publication number: 20130281300Abstract: Suggested are biocide compositions, comprising (a) 2-Furoic and/or Tetrahydro-2-furoic acid amides; (b) Biocides and optionally (c) Oil components or co-solvents and/or (d) Emulsifiers. The compositions show high solubility for biocides and improved emulsification properties.Type: ApplicationFiled: September 13, 2011Publication date: October 24, 2013Applicant: Cognis IP Management GmbHInventors: Joaquin Bigorra Llosas, Stefan Busch, Stéphanie Meriet, Javier Raya, Ramon Valls
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Patent number: 8563491Abstract: Methods of cleansing skin comprise the steps of contacting the skin with a cleansing compositions comprising a fatty ester in combination with a lipid, and either rinsing the composition from the skin with water or wiping the composition from the skin with a dry or damp substrate. The cleansing compositions can comprise at least 8%, by weight of the composition, of fatty ester and/or further comprise a nonionic surfactant and less than about 50%, by weight of the composition, of an alcohol solvent such as ethanol, isopropanol, or mixtures thereof. The methods and compositions provide skin cleansing and hydration benefits.Type: GrantFiled: March 3, 2006Date of Patent: October 22, 2013Assignee: The Procter & Gamble CompanyInventors: Timothy Woodrow Coffindaffer, Mannie Lee Clapp, Dennis Eugene Kuhlman, Kenneth Eugene Kyte, III, Daniel Burton Sears, Barbara Kay Williams
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Publication number: 20130272977Abstract: The present invention is directed to water-resistant compositions comprising: a reaction product of at least one heterocyclic compound chosen from thiolactone compounds and their thiocarbonyl analogs, and lactam compounds and their thiocarbonyl analogs; and at least one alkoxysilane having at least one amino substituent; and optionally, at least one carrier. These water-resistant compositions are capable of providing or acting as a carrier for delivering benefits to various substrates, for example, keratinous substrates such as skin and hair, while at the same time, imparting durable or long lasting hydrophobicity and/or a protective barrier onto said substrates.Type: ApplicationFiled: March 18, 2013Publication date: October 17, 2013Applicant: L'OREALInventors: Nghi Van NGUYEN, Gregory SHMUYLOVICH, Catherine CHIOU
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Publication number: 20130272981Abstract: The present invention is directed to water-resistant compositions comprising: a reaction product of at least one heterocyclic compound chosen from thiolactone compounds and their thiocarbonyl analogs, and lactam compounds and their thiocarbonyl analogs; and at least one compound having a functional group chosen from an amino group and a hydroxyl group; and optionally, at least one carrier. These water-resistant compositions are capable of providing or acting as a carrier for delivering benefits to various substrates, for example, keratinous substrates such as skin and hair, while at the same time, imparting durable or long lasting hydrophobicity and/or a protective barrier onto said substrates.Type: ApplicationFiled: March 18, 2013Publication date: October 17, 2013Applicant: L'OREALInventors: Nghi Van NGUYEN, Gregory SHMUYLOVICH, Catherine CHIOU
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Publication number: 20130274352Abstract: Compositions containing a drug to be delivered and at least one chemical permeation enhancer (CPE), and methods of making and using these compositions are described herein. In a preferred embodiment, the compositions contain two or more CPEs which behave in synergy to increase the permeability of the epithelium, while providing an acceptably low level of cytotoxicity to the cells. The concentration of the one or more CPEs is selected to provide the greatest amount of overall potential (OP). Additionally, the CPEs are selected based on the treatment. CPEs that behave primarily by transcellular transport are preferred for delivering drugs into epithelial cells. CPEs that behave primarily by paracellular transport are preferred for delivering drugs through epithelial cells. Also provided herein are mucoadhesive oral dosage forms. In a preferred embodiment, the oral dosage form is a multi-compartmental device, containing (i) a supporting compartment, (ii) drug compartment and (iii) mucoadhesive compartment.Type: ApplicationFiled: March 13, 2013Publication date: October 17, 2013Inventors: Kathryn Whitehead, Natalie Karr, Anubhav Arora, Samir Mitragotri, Vivek Gupta