Mineral Oil-water Type Patents (Class 514/939)
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Patent number: 6555121Abstract: Pesticidal compositions for quick knockdown, kill and control of household pests, the composition contains mineral oil and/or soybean oil, with and without other plant essential oils. In addition, the present invention is directed to a method for controlling household pests by applying a effective amount of the above pesticidal compositions to a locus where pest control is desired.Type: GrantFiled: May 29, 2001Date of Patent: April 29, 2003Assignee: Ecosmart Technologies, Inc.Inventors: Steven M. Bessette, Essam E. Enan
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Patent number: 6548557Abstract: The present invention relates to synthetic, novel, preferably fatty phosphoric acid esters which, when neutralized with a neutralizing agent, is revealed as a new surface active agent. Formulations are presented which demonstrate a method for using the disclosed surface active agent to prepare stable oil-in-water, water-in-oil emulsions and various solutions of varying polarity and viscosity for use in a variety of dermatological applications, and/or wherever emulsions or solutions according to the present invention may be used.Type: GrantFiled: November 6, 2000Date of Patent: April 15, 2003Assignee: Walter Merton Co., Inc.Inventor: Arnold W. Fogel
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Patent number: 6541018Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one glycerol fatty ester surfactant which is solid at a temperature of less than or equal to 45° C.; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion and methods for its use. Ideally, the emulsion is transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and, in the ophthalmological field, as an eye lotion for treating the eyes.Type: GrantFiled: December 16, 1999Date of Patent: April 1, 2003Assignee: L'OrealInventors: Jean-Thierry Simonnet, Odile Sonneville, Sylvie Legret
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Patent number: 6531500Abstract: An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone.Type: GrantFiled: May 12, 2000Date of Patent: March 11, 2003Assignee: Alwyn Company, Inc.Inventor: Elliott Farber
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Patent number: 6517816Abstract: There is provided a sunscreen emulsion composition. The composition has an inner discontinuous phase and an outer continuous phase. The inner discontinuous phase and/or outer continuous phase has a sunscreen active therein. The inner discontinuous phase is generally dispersed in the outer continuous phase and is in the form of discrete droplets having a multimodal droplet size distribution. There is also provided a method of protecting skin from overexposure to the sun in which the above composition is applied topically to the skin. There is also provided a method of enhancing the performance of a sunscreen emulsion by forming the inner discontinuous phase as a multiplicity of droplets having a multimodal droplet size distribution. There is also provided a method of preparing an emulsifier-free sunscreen composition.Type: GrantFiled: December 26, 2001Date of Patent: February 11, 2003Assignee: Avon Products, Inc.Inventors: Anthony D. Gonzalez, Andrew H. Pechko, Helen Wang
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Patent number: 6514508Abstract: An itch reducing device and method for reducing the itch of a mosquito bite. The itch reducing device and method includes a pad comprising an absorbent material. An itch reducing ointment generally saturates the pad. A package has an upper layer and a lower layer joined at perimeter edges of the upper and lower layers. The pad is positioned in the package for storage until needed.Type: GrantFiled: August 24, 2001Date of Patent: February 4, 2003Inventor: Jeffrey Rose
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Patent number: 6488946Abstract: The present invention relates to novel stable <<water-in-oil>> emulsions containing 5 to 70% by weight of an aqueous phase 20 to 90% by weight of a fatty phase; and 3 to 25% by weight of an emulsifier comprising 10 to 90% by weight, preferably 10 to 50% by weight and more preferably 10 to 40% by weight of a mixture in any proportion of an oleyl glycoside having a degree of polymerisation of between 1 and 3 and an isostearyl glycoside having a degree of polymerisation of between 1 and 3; and 90 to 10% by weight, preferably 90 to 50% by weight, and more preferably 90 to 60% by weight of a mixture in any proportion of oleyl alcohol and isostearyl alcohol and optionally 0 to 10% by weight of a co-emulsifier; 0 to 10% by weight of a stabiliser. Application: Cosmetic industry.Type: GrantFiled: September 17, 2001Date of Patent: December 3, 2002Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques-S.E.P.P.I.C.Inventors: Alain Milius, Alicia Roso, Nelly Michel
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Patent number: 6475526Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: June 5, 2001Date of Patent: November 5, 2002Inventor: Jeffrey B. Smith
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Patent number: 6472437Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.Type: GrantFiled: June 1, 2001Date of Patent: October 29, 2002Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ernest H. Braue, Jr., Stephen T. Hobson, Erich K. Lehnert
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Patent number: 6472438Abstract: A topical skin protectant formulation containing a barrier cream and a reactive moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and a reactive moiety that serves to neutralize chemical warfare agents into less toxic agents.Type: GrantFiled: June 1, 2001Date of Patent: October 29, 2002Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ernest H. Braue, Jr., Millard M. Mershon, Catherine R. Braue, Ruth A. Way
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Patent number: 6464993Abstract: The present invention relates to the use of a composition comprising: 10 to 90% by weight, preferably 10 to 50% by weight and particularly preferably 10 to 40% by weight of an isostearyl glycoside with a degree of polymerization of between 1 and 3; and 90 to 10% by weight, preferably 90 to 50% by weight and particularly preferably 90 to 60% by weight of isostearyl alcohol as an agent for improving the water resistance of a cosmetic composition.Type: GrantFiled: September 27, 2001Date of Patent: October 15, 2002Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques-SeppicInventors: Alain Milius, Nelly Michel, Bernard Branco, Jean-Pierre Boiteux, Chantal Almaric, Alicia Roso
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Patent number: 6461625Abstract: A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising a surfactant chosen from the alkoxylated alkenyl succinates, the alkoxylated alkenyl succinates of glucose and the alkoxylated alkenyl succinates of methylglucose, and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition.Type: GrantFiled: January 24, 2000Date of Patent: October 8, 2002Assignee: L'OrealInventors: Jean-Thierry Simonnet, Odile Sonneville, Sylvie Legret
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Patent number: 6458383Abstract: A delayed release pharmaceutical dosage form for oral administration of a hydrophilic drug, e.g., a polysaccharide drug such as low molecular weight heparin, are provided. The dosage form comprises a composition of: (a) a therapeutically effective amount of low molecular weight heparin; (b) a bile salt or bile acid; (c) at least one surfactant selected from hydrophilic surfactants, lipophilic surfactants, and mixtures thereof; and a means for delaying release of the composition from the dosage form following oral administration. Osmotic drug delivery systems for oral administration of a hydrophilic drug are also provided, wherein an osmotically activated device houses the drug, a bile salt or bile acid, and at least one surfactant selected from the group consisting of hydrophilic surfactants, lipophilic surfactants, and mixtures thereof. Methods for administering hydrophilic drugs, particularly polysaccharide drugs such as low molecular weight heparin, are also provided.Type: GrantFiled: December 29, 2000Date of Patent: October 1, 2002Assignee: Lipocine, Inc.Inventors: Feng-Jing Chen, Mahesh V. Patel, David T. Fikstad
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Patent number: 6448297Abstract: The invention relates to alkyl phosphates, in particular their mixtures, of the formula in which R is C12-C22-alkyl, preferably C14-C18-alkyl, X is a group of the formulae NH3R1, NH2R2R3 or NHR4R5R6, Y is as defined for R or is as defined for X, and R1 is C8-C22-alkyl, R2 and R3 are C1-C22-alkyl or cyclohexyl, and R4, R5 and R6 are C1-C4-alkyl. These compounds, in particular the mixtures of mono- and diesters, are suitable as emulsifiers in the preparation of aqueous emulsions.Type: GrantFiled: June 1, 2000Date of Patent: September 10, 2002Assignee: Clariant GmbHInventors: Angelika Turowski-Wanke, Matthias Löffler
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Patent number: 6437005Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWAs). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.Type: GrantFiled: June 1, 2001Date of Patent: August 20, 2002Assignees: The United States of America as represented by the Secretary of the Army, Mainstream Engineering CorporationInventors: Stephen T. Hobson, Ernest H. Braue, Jr., Dwight Back
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Patent number: 6432439Abstract: An O/W emulsion composition comprising fluorometholone or clobetasone butyrate, a phospholipid, an oil, a nonionic water-soluble cellulose derivative, and water. The O/W composition has advantages that fluorometholone or clobetasone butyrate contained therein is highly bioavailable and that the solubility of fluorometholone or clobetasone butyrate and the concentration thereof present in the composition can be kept stable. Thus, this composition is usable for the treatment of various inflammatory diseases by the generalized or local administration thereof. It provides a drug which shows an anti-inflammatory activity equal or higher than that of commercially available eye drops comprising a suspension of such an active ingredient even when it is applied in a smaller dose than that of commercially available one and further provides a drug having excellent storability, which reduces apprehension of systemic side effects of fluorometholone or clobetasone butyrate when it is applied to the eyes.Type: GrantFiled: April 3, 2000Date of Patent: August 13, 2002Assignee: Wakamoto Pharmaceutical Co., Ltd.Inventors: Hidekazu Suzuki, Satoshi Yamazaki, Yoshikazu Naito, Masanobu Takeuchi, Yoshiaki Saito
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Patent number: 6420434Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.Type: GrantFiled: June 1, 2001Date of Patent: July 16, 2002Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ernest H. Braue, Jr., Stephen T. Hobson, James White, Richard Bley
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Patent number: 6417238Abstract: The present invention relates to synthetic, fatty phosphoric acid esters which, when neutralized with a neutralizing agent, is revealed as a new surface active agent, having emollient characteristics. Formulations are presented which demonstrate a method for using the disclosed surface active agent to prepare stable oil-in-water and water-in-oil emulsions of varying polarity and viscosity for use in a variety of dermatological applications, and/or wherever emulsions according to the present invention may be used.Type: GrantFiled: February 24, 2000Date of Patent: July 9, 2002Inventor: Arnold W. Fogel
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Patent number: 6416790Abstract: The concentrate is a liquid mixture of about 1000 parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 microhmo to about 1.2 to 3 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943. The liquid concentrate is applied directly to a skin surface area having a burn or other dermal lesion to protect the area from bacterial contamination.Type: GrantFiled: March 13, 2000Date of Patent: July 9, 2002Assignee: Aqua Med, Inc.Inventor: John D. Young
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Patent number: 6417236Abstract: A topical skin protectant formulation containing a barrier cream and an active hybrid organic-inorganic polysilsesquioxane material for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.Type: GrantFiled: June 1, 2001Date of Patent: July 9, 2002Assignees: The United States of America as represented by the Secretary of the Army, The Regents of the University of CaliforniaInventors: Stephen T. Hobson, Ernest H. Braue, Kenneth Shea
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Patent number: 6414039Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.Type: GrantFiled: June 1, 2001Date of Patent: July 2, 2002Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Ernest H. Braue, Jr., Stephen T. Hobson, Craig L. Hill, Eric Boring, Jeff Rhule
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Patent number: 6403653Abstract: A topical skin protectant formulation containing a barrier cream and an active moiety for protecting warfighters and civilians against all types of harmful chemicals, specifically chemical warfare agents (CWA's). The topical skin protectant offers a barrier property and an active moiety that serves to neutralize chemical warfare agents into less toxic agents.Type: GrantFiled: June 1, 2001Date of Patent: June 11, 2002Assignees: The United States of America as represented by the Secretary of the Army, Nanoscale Materials, Inc.Inventors: Stephen T. Hobson, Ernest H. Braue, Jr., Erich K. Lehnert, Kenneth J. Klabunde, Olga P. Koper, Shawn Decker
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Patent number: 6387961Abstract: Alkyl 2-acetamido-2-deoxy-D-glucopyranoside uronic acids, and their pharmaceutically or cosmetically acceptable salts, and their use as surface-active and/or interfacially active active compounds, in particular as detergent surfactants or emulsifiers.Type: GrantFiled: September 12, 2000Date of Patent: May 14, 2002Assignee: Beiersdorf AGInventors: GĂĽnther Schneider, Hartmut Schmidt-LewerkĂĽhne, Joachim Thiem, Oliver Scheel
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Patent number: 6379688Abstract: A preservative for emulsion, comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid; an emulsion comprising sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid; an emulsion comprising the preservative; a method for preserving an emulsion comprising adding sorbic acid or a pharmaceutically acceptable salt thereof, and, where necessary, sodium edetate and boric acid, at a concentration pharmaceutically acceptable and effective for the preservation of the emulsion; use of sorbic acid or a pharmaceutically acceptable salt thereof for the production of an emulsion or preservative for emulsion; and the use comprising adding, where necessary, sodium edetate and boric acid.Type: GrantFiled: February 24, 1998Date of Patent: April 30, 2002Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Masazumi Yamaguchi, Masayo Yamaguchi, Katsuhiro Inada
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Patent number: 6346239Abstract: Use of a composition having an oil phase, an aqueous phase, at least one emulsifier of water-in-oil (W/O) type and at least one emulsifier of oil-in-water (O/W) type, in the form of a reverse latex comprising from 20% to 70% by weight, and preferably from 25% to 40% by weight, of an anionic polyelectrolyte, the anionic polyelectrolyte being based on partially neutralized acrylic acid, which may be branched and/or crosslinked, to prepare a cosmetic, dermopharmaceutical or pharmaceutical composition. Novel lattices, process for their preparation and cosmetic, dermopharmaceutical or pharmaceutical composition incorporating them.Type: GrantFiled: December 17, 1999Date of Patent: February 12, 2002Assignee: Societe d'Exploitation de Produits Pour les Industries Chimques SeppicInventors: Paul Mallo, Guy Tabacchi, Jean Pierre Boiteux
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Patent number: 6329413Abstract: An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The pH of the composition is in a range of from about 5.0 to about 6.5. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.Type: GrantFiled: May 12, 2000Date of Patent: December 11, 2001Assignee: Alwyn Company, Inc.Inventor: Elliott Farber
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Patent number: 6323246Abstract: A fatty acid amphoteric surfactant complex obtained by mixing a) at least one imidazolinium ampholytic surfactant of the formula: wherein R1 represents an alkyl or alkenyl group having 9 to 17 carbon atoms on average; and Z is 1 or 2; with b) a higher fatty acid selected from the group consisting of oleic acid, isostearic acid and a mixture of oleic acid and isostearic acid; wherein the ratio of said higher fatty acid to the total amount of said imidazolinium ampholytic surfactant(s) in said complex ranges from about 25:75 to 90:10. The complex containing an ampholytic and/or semipolar surfactant and higher fatty acid may optionally contain a clay mineral. Said complex may be employed in making emulsions.Type: GrantFiled: September 16, 1998Date of Patent: November 27, 2001Assignee: Shiseido Company, Ltd.Inventors: Yasunari Nakama, Michihiro Yamaguchi, Kiyoshi Miyazawa, Takayuki Ohmura
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Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
Patent number: 6309663Abstract: The present invention relates to pharmaceutical compositions, pharmaceutical systems, and methods for enhanced absorption of hydrophilic therapeutic agents. Compositions and systems of the present invention include an absorption enhancing carrier, where the carrier is formed from a combination of at least two surfactants, at least one of which is hydrophilic. A hydrophilic therapeutic agent can be incorporated into the composition, or can be co-administered with the composition as part of a pharmaceutical system. The invention also provides methods of treatment with hydrophilic therapeutic agents using these compositions and systems.Type: GrantFiled: August 17, 1999Date of Patent: October 30, 2001Assignee: Lipocine Inc.Inventors: Mahesh V. Patel, Feng-Jing Chen -
Patent number: 6306915Abstract: The present invention provides a method of making an emulsified composition employing an emulsifier containing a sphingoglycolipid which has a structure represented by the following formula: wherein R1 is a saccharide moiety which consists of three to four hexoses selected from the group consisting of uronic acid, glucosamine, galactose, and mannose, or one uronic acid; R2 is an alkyl group, which may have a cycloalkyl group, an alkenyl group, or an alkynyl group; and R3 is an alkyl group. The alkyl group, the alkenyl group and the alkynyl group may have a normal chain or a branched chain, and may be substituted or unsubstituted. The emulsifier of the present invention has marked moisturizing effect, skin roughening preventing effect, and emulsifying effect.Type: GrantFiled: August 9, 1999Date of Patent: October 23, 2001Assignee: Kibun Food Chemifa Co., LtdInventor: Katsumi Murata
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Patent number: 6281236Abstract: A skin cream composition containing allantoin and an emulsifier has improved stability coming from the adjustment of the pH to a range of 4.5 to 5.8. The lower pH preserves the stability of the allantoin and the functionality of the emulsifier system is maintained. The emulsifier system can be a nonionic emulsifier or an anionic emulsifier plus beeswax. The acid used to adjust the pH can be an organic acid or an inorganic acid. The composition can further comprise other ingredients such as herbal extracts, chelating agents, preservatives, emollients, solvents, and fragrance.Type: GrantFiled: July 23, 1999Date of Patent: August 28, 2001Assignee: Alwyn Company, Inc.Inventor: Elliott Farber
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Patent number: 6255350Abstract: This invention relates to a single phase emulsifiable concentrate composition comprising (a) between about 0.05 and about 25 wt. % of a biologically, fungicidally and/or herbicidally active aza compound; (b) between about 2 and about 40 wt. % of a lactam selected from the group of N-methyl pyrrolidone, N-methyl caprolactam, a C8 to C18 alkyl pyrrolidone, a C8 to C18 caprolactam and a mixture thereof; (c) between about 2 and about 20 wt. % of a moisture scavenging agent selected from the group consisting of a liquid molecularly hindered carbodiimide, a molecular sieve or a mixture thereof and (d) between about 10 and about 80 wt. % of a mixture of at least two non-ionic surfactants having an overall hydrophilic/lipophilic balance (HLB) above 7. The invention also relates to the stable oil-in-water (o/w) miniemulsions prepared from the above by dilution to between about 40 and about 99.99 wt. % water for a “pour on”, dip or spray solution useful in the treatment of animals or plants.Type: GrantFiled: October 9, 1998Date of Patent: July 3, 2001Assignee: ISP Investments Inc.Inventors: Domingo I. Jon, Donald I. Prettypaul, Matthew J. Benning, Kolazi S. Narayanan, Robert M. Ianniello
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Patent number: 6255253Abstract: An agrochemical microemulsion containing: (a) an alkyl (oligo)glycoside; and (b) an oil phase containing: (i) an organic water-insoluble solvent selected from the group consisting of N,N-dimethyl amides of C8-22 fatty acids, glycerol C8-22 fatty acid esters of natural or synthetic origin, dialkyl ether having a total of from 12 to 24 carbon atoms, monohydric primary alcohols having from 12 to 24 carbon atoms, and mixtures thereof; and (ii) an agrochemical, and wherein 80% of the microemulsion contains droplets between 10 and 100 nm in size.Type: GrantFiled: May 19, 2000Date of Patent: July 3, 2001Assignee: Cognis Deutschland GmbHInventors: Thomas Foerster, Marcus Claas, Horst-Werner Wollenweber
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Patent number: 6251415Abstract: A novel three component solvent system consisting of glyceryl triacetate, a substituted biphenyl, and a mixture of isoparafinic hydrocarbons is disclosed. The system is useful in the formulation of pesticides, and the use of the system to prepare emulsifiable concentrates and microemulsions is exemplified.Type: GrantFiled: October 27, 1997Date of Patent: June 26, 2001Assignee: FMC CorporationInventor: Richard M. Herbert
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Patent number: 6197283Abstract: W/O emulsions comprising dispersed therein crosslinked, water-swellable polymers consisting of a) 35-100% by weight of ionic monomers, b) 0-65% by weight of nonionic monomers, c) 0.3-1 mol-%, based on a) and b), of at least one at least bifunctional monomer, where the oil phase consists of one or more fatty acid esters, are used as thickeners in cosmetic or pharmaceutical formulations.Type: GrantFiled: April 4, 2000Date of Patent: March 6, 2001Assignee: BASF AktiengesellschaftInventors: Kristin Tiefensee, Volker Schehlmann, Martin RĂĽbenacker
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Patent number: 6197287Abstract: Composition comprising an oil phase, an aqueous phase, at least one emulsifier of water-in-oil (W/O) type, at least one emulsifier of oil-in-water (O/W) type, characterized in that the composition is an inverted latex comprising from 20% to 60% by weight, and preferably from 25% to 45% by weight, of a branched or crosslinked anionic polyelectrolyte based on at least one monomer possessing a strongly acidic function, copolymerized either with at least one monomer possessing a weakly acidic function or with at least one neutral monomer. The compositions have cosmetic applications.Type: GrantFiled: January 19, 1999Date of Patent: March 6, 2001Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques SeppicInventors: Paul Mallo, Guy Tabacchi, Jean-Pierre Boiteux
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Patent number: 6169117Abstract: The present invention provides a method of delivering an emulsion or suspension containing a supersaturated gas into a gas-depleted environment. The method generally comprises the steps of preparing an emulsion or suspension, exposing the emulsion or suspension to a gas at a pressure greater than 2 bar, and delivering the emulsion or suspension to a gas-depleted environment at ambient pressure.Type: GrantFiled: September 1, 1998Date of Patent: January 2, 2001Assignee: Wayne State UniversityInventor: J. Richard Spears
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Patent number: 6162453Abstract: A stable monophasic liquid composition characterized by the ability to solubilize increased amounts of surfactant into the composition while retaining a monophasic state, the composition comprising: one or more surfactants selected from the group consisting of cationic surfactants, anionic surfactants, amphoteric surfactants, nonionic surfactants, and mixtures thereof; a hydrophobic material; and one or more coupling agents selected from the group consisting of straight, branched and cyclic alkanes containing 7 to 12 carbon atoms and substituted with two hydroxyl groups, and alkoxylates thereof containing up to 20 alkoxy units each of which is ethoxy, propoxy, or butoxy, and mixtures thereof, in an amount of the one or more coupling agents effective to increase the amount of the one or more surfactants that can be solubilized in the monophasic composition.Type: GrantFiled: September 3, 1999Date of Patent: December 19, 2000Assignee: Witco CorporationInventor: Robert O. Keys
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Patent number: 6156326Abstract: Alkyl 2-acetamido-2-deoxy-D-glucopyranoside uronic acids, and their pharmaceutically or cosmetically acceptable salts, and their use as surface-active and/or interfacially active active compounds, in particular as detergent surfactants or emulsifiers.Type: GrantFiled: December 23, 1999Date of Patent: December 5, 2000Assignee: Beiersdorf AGInventors: Gunther Schneider, Hartmut Schmidt-Lewerkuhne, Joachim Thiem, Oliver Scheel
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Patent number: 6113921Abstract: The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a combination with the oil spheres in an aqueous suspension or emulsion. Optionally, a skin penetration enhancer may be included in such formulations. Such preparations achieve improved bioavailability and exert larger pharmacological effects than an equivalent dose of the drug or cosmetic formulated in conventional creams, lotions or oleaginous bases.Type: GrantFiled: January 13, 1998Date of Patent: September 5, 2000Assignee: Pharmos Corp.Inventors: Doron Friedman, Joseph Schwartz, Haim Aviv
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Patent number: 6106848Abstract: Stable, topically applicable oil-in-water bioaffecting emulsions having intermediate viscosity, characteristically ranging from 3 to 10 Pa.multidot.s, comprise (a) from 30% to 50% by weight of at least one pro-penetrating glycol, (b) at least one emulsifying agent, advantageously an anionic amphiphilic polymer, and (c) at least one biologically active agent, for example an active agent that modulates skin differentiation and/or proliferation and/or pigmentation, an anti-inflammatory, an antibacterial, an antifungal, etc.Type: GrantFiled: September 22, 1997Date of Patent: August 22, 2000Assignee: Centre International de Recherches DermatologiquesInventors: Isabelle Preuilh, Nathalie Willcox
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Patent number: 6071524Abstract: A composition in the form a dispersion for cosmetic, dermatological or pharmaceutical use containing: (a) 60 to 98% by weight of an aqueous phase and (b) 2 to 40% by weight of an oily phase dispersed in the aqueous phase, said oily phase being dispersed and stabilized by using cubic gel particles, said particles being essentially formed of: ( ) 0.1 to 15% by weight relative to the total weight of the composition of at least one unsaturated fatty acid monoglyceride having a C.sub.16 -C.sub.22 unsaturated fatty chain in a mixture with phytanetriol, and 0.05 to 3% by weight relative to the total weight of the composition of a dispersing and stabilizing agent, said agent being a surface active substance, water-soluble at room temperature, containing a linear or branched, saturated or unsaturated, fatty chain having 8 to 22 carbon atoms. Also claimed are methods of making said compositions.Type: GrantFiled: December 12, 1997Date of Patent: June 6, 2000Assignee: L'OrealInventors: Alain Ribier, Bruno Biatry
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Patent number: 6066328Abstract: The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or oligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.Type: GrantFiled: November 4, 1998Date of Patent: May 23, 2000Assignee: L'OrealInventors: Alain Ribier, Jean-Thierry Simonnet, Jacques Michelet
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Patent number: 6028117Abstract: Disclosed herein are microemulsion insecticides that do not contain conventional actives. The microemulsion form permits insects to be killed by an oil/surfactant combination.Type: GrantFiled: December 18, 1996Date of Patent: February 22, 2000Assignee: S. C. Johnson & Son, Inc.Inventor: John D. Hagarty
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Patent number: 6020375Abstract: A bactericidal composition comprising a hypertonic solution and a surfactant, and having an osmotic pressure of not less than 300 mOsm. The bactericidal composition of the present invention shows an unexpectedly high bactericidal activity. Such a highly bactericidal composition can be used as an external agent, a disinfectant, an agent for contact lenses and the like.Type: GrantFiled: June 10, 1998Date of Patent: February 1, 2000Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Shuichi Nishihata, Masayo Yamaguchi
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Patent number: 6015832Abstract: Methods for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of bacteria such as Bacillus.Type: GrantFiled: December 31, 1997Date of Patent: January 18, 2000Assignee: The Regents of the University of MichiganInventors: James R. Baker, Jr., D. Craig Wright, Michael M. Hayes, Tarek Hamouda, Joan Brisker
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Patent number: 6001346Abstract: A sprayable or solid biodegradable wax carrier for insect pheromones and a method for constant release rate of the pheromone from the biodegradable wax. A composition comprising a pheromone and paraffin wax formulated as an aqueous emulsion or a solid suitable for application to a surface of a tree or crop for mating disruption of insect pests. Pheromone is released by diffusion or by partitioning from the biodegradable wax carrier or by pheromone exposure due to the biodegradable wax carrier degradation.Type: GrantFiled: September 9, 1996Date of Patent: December 14, 1999Assignee: The Regents of the University of CaliforniaInventors: Michael Delwiche, John M. Krochta, Richard E. Rice, Cynthia Atterholt
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Patent number: 5993831Abstract: A composition containing, in a suitable carrier, nanoparticles of one or more nonbiodegradable polymer(s) encapsulating an oily phase which contains at least one active oil and/or at least one carrier oil and/or at least one active ingredient in an active oil and/or a carrier oil. At least one active ingredient is chosen from those with prolonged cosmetic and/or pharmaceutical activity. The nanocapsules have a size of 100-1000 nm.Type: GrantFiled: May 10, 1993Date of Patent: November 30, 1999Assignee: L'OrealInventors: Alain Ribier, Pascal Richart, Rose-Marie Handjani
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Patent number: 5958383Abstract: A lotion such as a sunscreen includes a color indicator which colorizes the lotion until the lotion is applied to human skin, whereinafter the colored lotion changes color or turns clear. A physiological color indicator such as a pH indicator, a colorant, or a water-soluble dye such as coumarin can be used, alone or in combination, to colorize the lotion in accord with the invention. The lotion is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protection sunscreens so that a user can ensure even distribution of the sunscreen on the body. A sunscreen of the invention can also include an emollient, such as jacoba oil, an emulsifier, a surfactant, such as sorbitol, water, and a pH adjuster, such as triethanolamine.Type: GrantFiled: December 21, 1998Date of Patent: September 28, 1999Assignee: IPA, L.L.C.Inventors: John McEleney, Wende Reenstra, Curtis A. Vock
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Patent number: 5955062Abstract: A lotion such as a sunscreen includes a pH indicator which colorizes the lotion until the lotion is applied to the human skin, whereinafter the colored lotion turns clear. A physiologically compatible pH indicator such as phenolphthalein is used which has a red appearance from pH 7.5+ and which has a clear appearance from about pH 7.0 to 7.5, the general pH range of the skin. The invention is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protecting sunscreens so that a user can ensure even distribution of the sunscreen on the body. In certain aspects of the invention, a cap houses the pH indicator and attaches to a container of the lotion, e.g., a sunscreen. The pH indicator mixes with the lotion as it is applied to the skin.Type: GrantFiled: February 17, 1998Date of Patent: September 21, 1999Assignee: SeeUVInventors: John McEleney, Wende Reenstra, Curtis A. Vock
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Patent number: 5928632Abstract: A surfactant free skin conditioning composition comprising a primary emollient of a gelled mineral oil, and emulsion stabilizer including at least one of a high molecular weight homopolymer of polyacrylic acid or a copolymer having a major proportion of a monoolefinically unsaturated carboxylic monomer or its anhydride, of 3 to 6 carbon atoms, and a minor proportion of a long chain acrylate or methacrylate ester monomer, gives superior deposition of skin conditioning emollients when applied to human skin, and rinsed off.Type: GrantFiled: September 19, 1997Date of Patent: July 27, 1999Assignee: The Andrew Jergens CompanyInventor: Rick Reusch