Ointment Or Salve Base Patents (Class 514/969)
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Patent number: 6417170Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.Type: GrantFiled: June 4, 2001Date of Patent: July 9, 2002Assignee: Pro-Neuron, Inc.Inventors: Reid W. von Borstel, Fedor Romantsev
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Patent number: 6406721Abstract: A salve for treating burns for reducing pain and scarring to burned skin. The salve for treating burns includes combining 3 parts of pork fat with 2 parts of chopped Hydrangea plant by weight to form a mixture. Heating the mixture at a temperature of 175 degrees Celsius until the Hydrangea plant has turned brown. Straining the mixture to define a strained mixture. Cooling the strained mixture to a temperature less than 35 degrees Celsius such that the strained mixture solidifies.Type: GrantFiled: June 22, 2001Date of Patent: June 18, 2002Inventors: Wentzel W. Owens, Ansil White, Charles Farley
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Patent number: 6387418Abstract: Pomegranate extracts and methods of use thereof are provided. Particularly, an antioxidative composition comprising an extract from pomegranate is provided. A method of reducing lipid peroxidation, aggregation or retention, HDL oxidation in a sample and a method of alleviating atherosclerosis in a patient are also provided.Type: GrantFiled: April 19, 1999Date of Patent: May 14, 2002Assignee: Stewart and Lynda Resnick Revocable TrustInventors: Michael Aviram, Leslie Dornfeld
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Patent number: 6379673Abstract: The invention provides a herbal formulation useful as a therapeutic and cosmetic applications for the treatment of general skin disorders, said composition comprising at least two or more plant extracts in the form of oil or powder or mixtures thereof, the said plants extracts being selected from the group consisting of Gymnena sylvestrae water extract 3 to 6 wt. %; Tridax procumbens water extract 3 to 6 wt. %; its methanolic extract 4 to 6 wt. %, Allium sativum oilhexane extract 1 to 3 wt. %; dried juice of Aloe vera 2 to 6 wt. %; Gum olibanum powder in the natural form 4 to 7 wt. %; Gum olibanum resinoid or its organic extract 3 to 8 wt. %; and resinoid free Gum olibanum meal 5 to 10 wt. %., optionally, including any drug having anti-inflammatory and wound healing property or mixture thereof, the said drug being selected from the group consisting of Disclofenac sodium 1-3 wt. %, Salicyclic acid 1 to 4 wt. %, Piroxicam 1 to 2 wt. %, Turmeric powder 0.1 to 1 wt.Type: GrantFiled: October 18, 2000Date of Patent: April 30, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Prakash Vaman Rao Diwan, Bhamidipalli Subrahmanya Sitaramam, Sistla Ramakrishna, Kondapuram Vijaya Raghavan
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Patent number: 6375993Abstract: Pomegranate extracts and methods of use thereof are provided. Particularly, an antioxidative composition comprising an extract from pomegranate is provided. A method of reducing lipid peroxidation, aggregation or retention, HDL oxidation in a sample and a method of alleviating atherosclerosis in a patient are also provided.Type: GrantFiled: September 21, 1999Date of Patent: April 23, 2002Assignee: Stewart and Lynda Resnick Revocable TrustInventors: Michael Aviram, Leslie Dornfeld
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Patent number: 6368618Abstract: A novel topical formulation for delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) is characterized by enhanced transdermal absorption and efficacy. A two phase liquid composition has aqueous and oil phases, the oil phase having a relatively high concentration of the NSAID to enhance transdermal absorption and efficacy when incorporated into the topical anti-inflammatory formulation. The two phase liquid composition preferably contains, in addition to an NSAID, at least one melting point depressing agent. A preferred topical anti-inflammatory composition includes S(+)-ibuprofen, thymol, and ethyl alcohol or isopropyl alcohol.Type: GrantFiled: July 1, 1999Date of Patent: April 9, 2002Assignee: The University of Georgia Research Foundation, Inc.Inventors: H. Won Jun, Lisheng Kang
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Patent number: 6365131Abstract: Pharmaceutical dental gel preparation comprising of metronidazole benzoate, chlorhexidine gluconate, and local anesthetic as the active ingredient; glycol as the solvent medium; a carboxyvinyl polymer, cross-linked polymer of acrylic acid copolymerized with polyalkylsucrose as a gelling agent.Type: GrantFiled: January 10, 2000Date of Patent: April 2, 2002Assignee: J. B. Chemicals & Pharmaceuticals Ltd.Inventors: Madhukant Mansukhlal Doshi, Milind Dattatraya Joshi, Bharat Pravinchandra Mehta
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Patent number: 6365173Abstract: A polymeric carrier for delivery of bioactive or bioreactive molecules is provided, including a stereocomplex of one or more biocompatible polymers and having incorporated on or within the complex the molecules to be delivered. In a preferred embodiment, the biocompatible stereoselective polymers are linear or branched D-PLA homo- and block-polymers, linear or branched L-PLA homo- and block-polymers, copolymers thereof, or mixtures thereof, in stereocomplexed form. In one preferred embodiment, the polymeric carrier is complexed with a complementary stereospecific bioactive molecule. In other embodiments, the bioactive, or bioreactive (for example, for use in diagnostic applications), is bound to the complex by ionic, hydrogen, or other non-covalent binding reactions not involving stereocomplexation, or is physically entrapped within the complex, either at the time of complex formation or when the polymeric material is formulated into particles, tablets, or other form for pharmaceutical application.Type: GrantFiled: January 14, 1999Date of Patent: April 2, 2002Assignee: Efrat Biopolymers Ltd.Inventors: Abraham J. Domb, Zeev Zehavi
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Patent number: 6361807Abstract: Pomegranate extracts and methods of use thereof are provided. Particularly, an antioxidative composition comprising an extract from pomegranate is provided. A method of reducing lipid peroxidation, aggregation or retention, HDL oxidation in a sample and a method of alleviating atherosclerosis in a patient are also provided.Type: GrantFiled: September 21, 1999Date of Patent: March 26, 2002Assignee: Stewart and Lynda Resnick Revocable TrustInventors: Michael Aviram, Leslie Dornfeld
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Patent number: 6355226Abstract: A method of treating patients having viral infections including herpes simplex virus 1 and 2 infections and human papillomavirus infections by topically administering Product R, a peptide-nucleic acid preparation, by itself or in a composition comprising Product R and other pharmaceutically acceptable carriers for topical administration, is disclosed.Type: GrantFiled: August 30, 2000Date of Patent: March 12, 2002Assignee: Advanced Viral Research Corp.Inventor: Shalom Z. Hirschman
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Patent number: 6355262Abstract: A liniment is disclosed for use in conjunction with massage or other manual topical application method, and is adapted for any application where massage therapy is used as a part of a medically recommended treatment, particularly where pain management is involved. The liniment for topical application includes a mixture of ethyl alcohol, methyl hydrate and distilled water. To this solution is added horseradish and powdered cayenne pepper. The mixture is sealed for 25 days, with twice daily stirring or shaking. The particulate matter is allowed to settle for 3 days, after which the liniment is siphoned off for use. The liniment may be applied topically to the skin in areas of pain and discomfort.Type: GrantFiled: August 30, 2000Date of Patent: March 12, 2002Inventor: Sigmund Krentz
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Patent number: 6344188Abstract: A wrinkle reducing cream is presented which reduces wrinkles upon topical application to the skin. The main ingredients of the composition include a water and caffeine composition which is mixed together in a first vessel and a glycerin composition heated in a second vessel. The three components of the active ingredient are mixed carefully, making sure that any precipitate produced is remixed into the solution. After heating and mixing the components, the entire composition is cooled with care being taken to push any precipitate back into solution to ensure an even distribution of all of the components. The active ingredient thus produced may be combined with a suitable cosmetic vehicle to provide the topical wrinkle reducing composition. The composition is topically applied to the wrinkled area over a period of days or months in order to reduce or entirely eliminate wrinkles from the skin. The final active ingredient may also be used for other applications.Type: GrantFiled: March 1, 2000Date of Patent: February 5, 2002Assignee: Victor Silva, Inc.Inventors: Victor Silva, Bryan K. Harris, Gregory J. Rudroff, Andrew W. Szczesiul
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Patent number: 6342537Abstract: Gel for local treatment of skin diseases and for prophylaxis, characterized by containing more than 90% of a drying and/or protein coagulating, short-chained alcohol or alcohol mixture, primarily ethanol, and possibly adjuvants or additives and by containing a gelling agent, that possesses good skin-adhesive properties, that gives a matrix formation of alcohol or alcohol mixtures, that creates an evaporation inhibiting effect, gives a prolonged effect, and form a protective plaster when the gel has dried.Type: GrantFiled: October 13, 1999Date of Patent: January 29, 2002Inventors: John Brown Thomsen, Jens C. Moller
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Patent number: 6328988Abstract: Polymeric micelles for encapsulation of hydrophobic molecules are provided. Methods and formulations for delivering hydrophobic molecules to a host via these micelles are also provided. Methods of stabilizing liposomes or lipid based formulations by addition of polymeric micelles are also provided.Type: GrantFiled: October 21, 1999Date of Patent: December 11, 2001Assignee: Rutgers, The State University of New JerseyInventor: Kathryn E. Uhrich
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Patent number: 6322820Abstract: A composition of matter for treating hemorrhoids comprising a pharmaceutically acceptable carrier, between 1% and 10% by weight of zinc oxide, between 0.2% and 5% by weight of resorcinol and between 0.1% and 3% by weight of menthol. A preferred carrier is white petroleum jelly and the composition may further include hydrocortisone as an active ingredient.Type: GrantFiled: May 22, 2000Date of Patent: November 27, 2001Inventor: Sylvain Simoneau
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Patent number: 6299902Abstract: A novel topical anesthetic preparation is characterized by improved transdermal absorption and efficacy. In a preferred embodiment, the topical preparation contains at least one local anesthetic agent and at least two melting point depressing agents. Also provided is a two-phase liquid composition that contains aqueous and oil phases, the oil phase having a relatively high concentration of a local anesthetic agent to enhance transdermal absorption and efficacy when incorporated into a topical anesthetic preparation. A preferred topical anesthetic preparation includes lidocaine or tetracaine, thymol or menthol, and ethyl alcohol or isopropyl alcohol. The preparation is expected to be safe and effective in obtaining transdermal anesthesia on intact skin and mucous membrane of adults, children, infants and newborns.Type: GrantFiled: July 19, 1999Date of Patent: October 9, 2001Assignee: The University of Georgia Research Foundation, Inc.Inventors: H. Won Jun, Lisheng Kang
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Patent number: 6267971Abstract: The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as a firming agent for the skin and/or mucous membranes. The invention also relates to a firming composition comprising cinnamic acid or at least one of its derivatives.Type: GrantFiled: December 21, 1998Date of Patent: July 31, 2001Assignee: Societe L'Oreal S.A.Inventors: Lionel Breton, Florence Girerd, Béatrice Renault
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Patent number: 6264962Abstract: The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.Type: GrantFiled: December 21, 1998Date of Patent: July 24, 2001Assignee: Societe l'Oreal S.A.Inventors: Lionel Breton, Florence Girerd, Béatrice Renault
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Patent number: 6261544Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.Type: GrantFiled: February 15, 1999Date of Patent: July 17, 2001Assignee: Focal, Inc.Inventors: Arthur J. Coury, Luis Z. Avila, Chandrashekhar P. Pathak, Shikha P. Barman
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Patent number: 6258385Abstract: The invention relates to the use of electron active molecular crystals comprising tetrasilver tetroxide (Ag4O4) for the treatment and cure of dermatological skin conditions (diseases) ranging from dermatitis, acne and psoiasis to herpes and skin ulcers.Type: GrantFiled: April 18, 2000Date of Patent: July 10, 2001Assignee: Marantech Holding, LLCInventor: Marvin S. Antelman
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Patent number: 6251371Abstract: The present invention relates to use of dichlorobenzyl alcohol for preparing a preparation for topical treatment of inflammation and the preparation for this purpose. It is known to use dichlorobenzyl alcohol (2,4-DCBA) as an agent against bacteria and fungi, i.e. as a disinfectant. By the present invention it has, however, surprisingly turned out that dichlorobenzyl alcohol, preferably 2,4-dichlorobenzyl alcohol, is also useful for treatment of inflammation. The invention also relates to a preparation containing dichlorobenzyl alcohol, preferably 2,4-dichlorobenzyl alcohol, for topical treatment of inflammation, which can be applied onto skin or mucosa in the form of an ointment, a cream, a gel or a solution. Thus, the preparation has turned out to be effective against a variety of inflammatory conditions including skin diseases, such as pruritus and psoriasis, insect bites and stings.Type: GrantFiled: August 30, 1999Date of Patent: June 26, 2001Assignee: Bifodan A/SInventors: Hans Holmen, Arne Martinus Pedersen
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Patent number: 6242000Abstract: The use of S(−)sodium 2-(4-isobutylphenyl)propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(−)sodium 2-(4-isobutylphenyl)propionate dihydrate. Processes to prepare S(−)sodium 2-(4-isobutyl-phenyl)propionate and its use in a process to prepare S(+) 2-(4-isobutylphenyl)propionic acid of high enantiomeric purity are also described.Type: GrantFiled: October 2, 1997Date of Patent: June 5, 2001Assignee: The Boots Company PLCInventors: Bernard John Armitage, John Francis Lampard, Alan Smith
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Patent number: 6242010Abstract: Compositions for remediating ano-rectal inflammatory processes, hemorrhoidal syndromes and ano-rectal wounds. The composition includes the synergistic combination of reduced glutathione and selenium as a selenoamino acid in a suitable carrier for topical applications.Type: GrantFiled: July 21, 1999Date of Patent: June 5, 2001Assignee: Thione International, Inc.Inventor: Theodore Hersh
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Patent number: 6235294Abstract: The invention relates to a flavonoid ester. This flavonoid ester results from the reaction product of at least one flavonoid selected from the group consisting of a flavonoid with a ketone group in the 4-position, a salt, ester or ether of such a flavonoid, and a C-heteroside and/or O-heteroside derivative of such a flavonoid, with the proviso that this flavonoid contains at least one free alcohol group, with an organic monoacid having from 3 to 30 carbon atoms. These flavonoid esters constitute useful active principles for the manufacture of cosmetic, dermopharmaceutical, pharmaceutical, dietetic or agri-foodstuff compositions.Type: GrantFiled: July 10, 1998Date of Patent: May 22, 2001Assignee: ColeticaInventors: Eric Perrier, Anne-Marie Mariotte, Ahcéne Boumendjel, Delphine Bresson-Rival
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Patent number: 6225356Abstract: A composition and method for the treatment of the conditions vulvar vestibulitis, interstitial cystitis, vulvar vaginitis or vaginitis dynea wherein a composition containing cromolyn sodium in effective amount is applied to the vaginal vestibule area, with the application repeated as necessary to effectively address the symptoms and conditions. Preferably, the cromolyn sodium is present in an amount of about 2 to 10 percent in a carrier ointment or cream, with the carrier composition preferably comprising a mixture of pluronic gel and lecithin organogel.Type: GrantFiled: January 20, 2000Date of Patent: May 1, 2001Inventor: Tudor Jones, III
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Patent number: 6217885Abstract: The present invention relates to antipruritic cosmetic and/or pharmaceutical compositions for use on human or animal skin, comprising one or more mild local anesthetics, one or more astringents and/or, if appropriate, a substance having an antiinflammatory action.Type: GrantFiled: February 18, 1998Date of Patent: April 17, 2001Assignee: Bayer AktiengesellschaftInventors: Klaus Röder, Sabine Koch
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Patent number: 6214866Abstract: Pharmaceutical compositions comprising mupirocin and chlorhexidine are of use in treating topical bacterial infections, in particular infected burn injuries.Type: GrantFiled: March 16, 1999Date of Patent: April 10, 2001Assignee: SmithKline Beecham Pharmaceuticals (Pty) LimitedInventors: Monica Lucie Drogemoller, Stanley Leslie Linley
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Patent number: 6203796Abstract: A therapeutic composition comprising oregano oil, laurel oil, and myrtle oil useful in alleviating pain and discomfort associated with arthritis, migraines, bronchitis, soft tissue injuries, muscle aches and pains and neck and back pains and strains in humans, as well as upper respiratory, joint and shin ailments in animals.Type: GrantFiled: July 8, 1999Date of Patent: March 20, 2001Inventor: Andreas D. Papaprodromou
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Patent number: 6200570Abstract: The invention provides a herbal formulation useful as a therapeutic and cosmetic applications for the treatment of general skin disorders, the composition comprising at least two or more plant extracts in the form of oil or powder or mixtures thereof, the plant extracts being selected from the group consisting of Gymnena sylvestrae water extract 3 to 6 wt. %; Tridax procumbens water extract 3 to 6 wt. %; its methanolic extract 4 to 6 wt. %, Allium sativum oil hexane extract 1 to 3 wt. %; dried juice of Aloe vera 2 to 6 wt. %; Gum Olibanum powder in the natural form 4 to 7 wt. %; Gum Olibanum resinoid organic solvent extract 3 to 8 wt. %; and resinoid free Gum Olibanum meal 5 to 10 wt. %., optionally, including any drug having anti-inflammatory and wound healing property or mixture thereof, the drug being selected from the group consisting of Disclofenac sodium 1-3 wt. %, Salicyclic acid 1 to 4 wt. %, Piroxicam 1 to 2 wt. %, Turmeric powder 0.1 to 1 wt.Type: GrantFiled: November 25, 1998Date of Patent: March 13, 2001Assignee: Counsel of Scientific and Industrial ResearchInventors: Prakash Vaman Rao Diwan, Bhamidipalli Subrahmanya Sitaramam, Sistla Ramakrishna, Kondapuram Vijaya Raghavan
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Patent number: 6156293Abstract: The present invention relates to preparations alleviating the symptoms caused by drying of the mucous membranes of the body. The preparations contain trimethylglycine as an active agent. The invention also relates to the use of trimethylglycine as an agent alleviating the symptoms of dry mucous membranes in different preparations intended for the body care and hygiene, and to a method of alleviating the symptoms, caused by drying, appearing on the mucous membranes of the body.Type: GrantFiled: August 26, 1999Date of Patent: December 5, 2000Assignee: Finnfedds Finland Ltd.Inventors: Kirsti Jutila, Jorma Tenovuo, Eva Soderling
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Patent number: 6143278Abstract: The invention is directed to methods and pharmaceutical compositions for the topical administration of opioid analgesic drugs such as morphine. In particular, the invention relates to topical administration of an opioid analgesic agent, e.g., morphine sulfate, in admixture with a skin- or mucosal-specific penetration enhancer, to produce a localized analgesic effect in inflamed or non-inflamed skin or mucosal tissue, and without a transdermal or transmucosal migration of opioid agent, e.g., into the systemic circulation.Type: GrantFiled: February 23, 1998Date of Patent: November 7, 2000Inventor: George F. Elkhoury
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Patent number: 6136332Abstract: Transfer/migration-resistant, topically applicable dermatological/pharmaceutical compositions well suited for preventatively and/or curatively therapeutically treating human skin or mucous membranes, comprise at least one volatile oil, at least one phenylated silicone oil and at least one dermatologically and/or pharmaceutically bioaffecting active agent, for example at least one anviral, antibacterial, antifungal, anti-inflammatory, neuromediator modulator, etc.Type: GrantFiled: July 29, 1996Date of Patent: October 24, 2000Assignee: Societe L'Oreal S.A.Inventors: Jean-Fran.cedilla.ois Grollier, Josiane Allec, Isabelle Agostini
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Patent number: 6126957Abstract: The present invention relates, in general, to methods of treating disorders of the eye, and, in particular, to methods of preventing or treating elevated eye pressure and glaucoma. The invention further relates to compounds and compositions suitable for use in such methods.Type: GrantFiled: May 16, 1995Date of Patent: October 3, 2000Assignee: Duke UniversityInventor: David L. Epstein
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Patent number: 6126947Abstract: An inhibitor of cholesterol synthesis is used for the treatment, alleviation or prevention of skin disorders.Type: GrantFiled: October 15, 1997Date of Patent: October 3, 2000Assignee: Ramot Univ. Authority for App. Research & Indus. Dev. Ltd.Inventors: Naphtali Savion, Sara Brenner
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Patent number: 6121329Abstract: An external preparation for topical administration which aims at inhibiting rejection reactions at organ or bone marrow transplantation or treating autoimmune diseases or allergic diseases and contains as the active ingredient 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: August 27, 1997Date of Patent: September 19, 2000Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventors: Tsuneo Fujii, Tadashi Mishina, Koji Teshima, Tomonori Imayoshi
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Patent number: 6080395Abstract: A pharmaceutical composition of water, water soluble vinyl polymer gel, amine alcohol dispersant and IEP is used topically to treat herpes labialis and aphthous stomatitis lesions, and also to treat herpes genitalis, chicken pox, allergic conjunctivitis, giant papillary conjunctivitis, stomatitis secondary to chemotherapy, thermal burn, sunburn, and decubitus ulcers and shingles.Type: GrantFiled: November 20, 1998Date of Patent: June 27, 2000Assignee: Maxim Pharmaceutical, Inc.Inventors: Bruce A. Jack, B. Thomas White
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Patent number: 6063363Abstract: A method for alleviating the symptoms of an upper respiratory tract infection in humans employs the application of a composition containing, in a pharmaceutically acceptable carrier, 0.1 to 3.0 weight percent of a potassium salt such as one or more of potassium acetate, potassium aluminate, potassium arsenite solution, potassium bicarbonate, potassium bisulfate, potassium bitartarate, potassium bromide, potassium carbonate, potassium chloride, potassium citrate, potassium gluconate, potassium glycerophosphate, potassium iodate, potassium iodide, potassium manganate, potassium permanganate, potassium phosphate monobasic, potassium phosphate dibasic, potassium phosphate tribasic and potassium phosphite.Type: GrantFiled: May 27, 1997Date of Patent: May 16, 2000Inventors: Gary J Goodwin, Roberta L Goodwin
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Patent number: 6056966Abstract: Pharmaceutical compositions in topical or parenteral form containing specific organic mono- or dinitrates, some of them novel compounds, are effective in treating male impotence and erectile dysfunction through topical or intracavernosal administration to the penis. Methods of treatment utilizing the mono- or dinitrate-containing compositions are also disclosed.Type: GrantFiled: May 18, 1998Date of Patent: May 2, 2000Assignee: Baker Norton Pharmaceuticals, Inc.Inventors: Sami Selim, Robert Testman, Ho-Leung Fung, John A. Bauer
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Patent number: 6051244Abstract: Topical application of fructose-1,6-diphosphate, its derivatives and/or precursors are used for treating or preventing epidermal or mucosal aging and inflammation. In preferred embodiments, the fructose diphosphate (or its derivative) is applied in admixture with a dermally, ophthalmically, orally, or nasally acceptable carrier. Topical application lessens symptoms of urticaria, atopic dermatitis and allergic rhinitis and conjunctivitis among other inflammatory conditions and inhibit microscarring of the dermis.Type: GrantFiled: August 14, 1998Date of Patent: April 18, 2000Inventor: Nicholas V. Perricone
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Patent number: 6039955Abstract: A nontoxic, therapeutic agent having pharmacological activity comprising concentrated extract of Larrea tridentata plant material and ascorbic acid, an ascorbic acid ester, an ascorbic acid salt, butylated hydroxyanisole, butylated hydroxytoluene, hydrogen sulfide, hypophosphorous acid, monothioglycerol, potassium bisulfite, propyl gallate, sodium bisulfite, sodium hydrosulfite, sodium thiosulfate, sulfur dioxide, sulfurous acid, a tocopherol or vitamin E is made by a process in which the plant material is extracted using an organic solvent, preferably acetone, and is then saturated with one of the listed reducing agents acid to reduce the toxic NDGA quinone, which naturally occurs in the plant material, to NDGA itself.Type: GrantFiled: June 10, 1999Date of Patent: March 21, 2000Assignee: Larreacorp, Ltd.Inventors: Robert A. Sinnott, W. Dennis Clark, Kenneth Frank DeBoer
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Patent number: 6036963Abstract: Gluconolactone or glucarolactone in cosmetic skin care compositions, as anti-irritants, to reduce skin irritation, which may be intrinsic skin irritation or irritation caused by hydroxy acids or certain retinoids.Type: GrantFiled: February 26, 1998Date of Patent: March 14, 2000Assignee: Chesebrough-Ponds's USA Co., Division of Conopco, Inc.Inventors: Ronni Weinkauf, Uma Santhanam, Laura Palanker, Donald Rick, John Bartolone
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Patent number: 6025389Abstract: The invention is directed to a pharmaceutical composition comprising a cream base which comprises mupiricin dihydrate, a mineral oil, one or more fatty alcohols or fatty esters, a polyoxyethylene ether or ester surfactant, xanthan gum, water and a method for treating a bacterial infection using said composition.Type: GrantFiled: July 25, 1997Date of Patent: February 15, 2000Assignee: SmithKline Beecham CorporationInventor: Harvey Lee Zimmerman
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Patent number: 6022558Abstract: The present invention is related to a trandermal preparation of oxicams. In preparation, it is comprised of 0.1% to 50% of an oxicam, 0.1% to 70% of pure compositions from Chinese herbal enhancers as enhancers, as well as other necessary excipients for transdermal delivery of an active ingredient. This transdermal preparation is intended to be used for anti-inflammatory cases, but with few gastrointestinal side effects. Based on results from testing this preparation on nude mice skin, rabbit skin, and human leg skin, it was found that skin penetration of the transdermal preparation containing 20% terpineol oil was 157.6 times higher than that of the control group.Type: GrantFiled: July 1, 1997Date of Patent: February 8, 2000Inventors: Oliver Yoa-Pu Hu, Chieh Fu Chen
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Patent number: 6019990Abstract: New cosmetic formulations containing free and derivatized forms of conjugated linoleic acid. These ingredients have beneficial effects related to their medicinal and nutritional properties, but also are engineered for their compatibility with standard cosmetic ingredients. Certain vitamin/conjugated linoleic acid combinational molecules are described which deliver equimolar amounts of both free components to viable layers of the epidermis, thereby obtaining multiple functionality of the final product.Type: GrantFiled: November 21, 1997Date of Patent: February 1, 2000Assignee: Natural Nutrition Ltd. ASInventor: Jan Remmereit
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Patent number: 6017551Abstract: A salve or skin care product for treating discomfort due to burned, inflamed or irritated skin includes a mixture of naturally occurring neutral organic glyceryl esters of fatty acids, such as lard, and small particles of the bark of an Alder tree. The small particles are obtained by pulverized, milling or the like.Type: GrantFiled: December 11, 1998Date of Patent: January 25, 2000Inventor: George E. Riley
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Patent number: 6015568Abstract: Anhydrous, stable retinol-based cosmetic or pharmaceutical composition for the skin. This composition contains solubilized retinol in an organic solution which is liquid at ambient temperature and which is chosen from the group comprising:i) aliphatic fatty alcohols having a branched chain at C.sub.16 -C.sub.20,ii) saturated alcoxylated fatty alcohols having a straight or branched chain at C.sub.16 -C.sub.20,iii) the diesters of dicarboxylic esters at C.sub.6 -C.sub.14 and of isopropyl alcohol, and mixtures of these solvents.This composition is intended for the treatment of skin disorders, and of acne in particular.Type: GrantFiled: April 4, 1996Date of Patent: January 18, 2000Assignee: L'OrealInventors: Evelyne Segot, Jean-Pierre Laugier
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Patent number: 6015573Abstract: Compositions for topical use in herpes virus infections comprising anti-herpes nucleoside analogue phosphate esters, such as acyclovir monophosphate and acyclovir diphosphate, which show increased activity against native strains of herpes virus as well as against resistant strains, particularly thymidine kinase negative strains of virus. Also disclosed are methods for using the topical compositions in treatment of herpes disease.Type: GrantFiled: December 16, 1997Date of Patent: January 18, 2000Inventor: Karl Y. Hostetler
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Patent number: 6013260Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.Type: GrantFiled: January 14, 1999Date of Patent: January 11, 2000Inventor: Bobby Gene Edwards
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Patent number: 6013277Abstract: Description of pharmaceutical or cosmetic compositions aimed at improving the local microcirculation of the penis for chronic topical treatment of vascular impotence due to vascular causes, with main impairment of the arterial-arteriolar afferents of the cavernous bodies. The new pharmacological properties of the complex between PGE1 and/or Troxerutine with Phosphatidylcholine are administered locally on the skin of the penis; the activity is obtained using the T.E.B. system according to Curri.Type: GrantFiled: March 8, 1996Date of Patent: January 11, 2000Assignee: Inpharma S.A.Inventor: Sergio Curri
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Patent number: 6011022Abstract: The invention is directed to methods and pharmaceutical compositions for the topical administration of analgesic drugs which affects peripheral muscarinic receptors such as neostigmine. In particular, the invention relates to topical administration of an analgesic agent, e.g., neostigmine, optionally in admixture with a skin- or mucosal-specific penetration enhancer, to produce a localized analgesic effect in inflamed or non-inflamed skin or mucosal tissue, and without a transdermal or transmucosal migration of the agent, e.g., into the central nervous system.Type: GrantFiled: May 21, 1998Date of Patent: January 4, 2000Inventor: George F. El Khoury