Material Contains A Group Ia (li, Na, K, Rb, Cs, Fr) Or Group Iia Metal Atom (be, Mg, Ca, Sr, Ba, Ra) Patents (Class 528/358)
  • Publication number: 20150148516
    Abstract: The present invention discloses new catalyst systems based on complexes of divalent metals supported by chelating phenoxy ligands for immortal ring-opening polymerisation of cyclic esters and cyclic carbonates.
    Type: Application
    Filed: November 25, 2014
    Publication date: May 28, 2015
    Inventors: Jean-Francois Carpentier, Yann Sarazin, Valentin Poirier, Marion Helou
  • Publication number: 20140364580
    Abstract: The invention provides a metal alkoxide complex of Formula (I), wherein X, M, R1, R2, R3, m, n, y and z are as defined in the Description. The invention also provides a catalyst composition comprising the metal alkoxide complex and a hydroxy-containing compound, wherein the molar ratio of the metal alkoxide complex to the hydroxy-containing compound is 1:01-1000. The invention also provides a production method of poly-?- caprolactone or polyactide, wherein an ?-caprolactone monomer or a lactide monomer is reacted in the presence of the metal alkoxide complex or catalyst composition to obtain poly-?-caprolactone or polylactide. The metal alkoxide complex and the catalyst composition thereof can be used to catalyze the synthesis of poly-?- caprolactone or polylactide with a high efficiency.
    Type: Application
    Filed: September 11, 2012
    Publication date: December 11, 2014
    Applicant: Changchun Institute of Applied Chemistry Chinese Academy of Sciences
    Inventors: Dongmei Cui, Xinli Liu, Bo Liu, Shihui Li, Dongtao Liu, Chunji Wu
  • Patent number: 8575302
    Abstract: A composition which comprises polylactide and has excellent heat stability, color and hydrolytic resistance. The composition comprises (i) polylactide, (ii) a metal catalyst and (iii) a hypophosphorous acid-based deactivator or a metaphosphoric acid-based deactivator.
    Type: Grant
    Filed: October 4, 2006
    Date of Patent: November 5, 2013
    Assignees: Teijin Limited, Musashino Chemical Laboratory, Ltd.
    Inventors: Hirotaka Suzuki, Kiyotsuna Toyohara, Shin To
  • Patent number: 8492565
    Abstract: To provide a process for producing BPDA whereby high productivity is attained while high purity is maintained. A process for producing biphenyltetracarboxylic acid dianhydride, which comprises heating biphenyltetracarboxylic acid to produce biphenyltetracarboxylic acid dianhydride, characterized in that the heating is carried out at a pressure of from 1×102 Pa to 1.1×105 Pa to a maximum temperature in a range of from 210° C. to 250° C. in such a manner that the temperature rising rate is higher than 50° C./hr for a period of at least ¼ of the time for the temperature rise from 60° C. to 210° C., and the temperature is maintained to be from 150° C. to 250° C. for from 0.5 to 10 hours.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: July 23, 2013
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Hiroshi Mikami, Makoto Nitta, Naoki Noguchi
  • Patent number: 8476402
    Abstract: The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: July 2, 2013
    Assignee: Imperial Innovations Limited
    Inventors: Charlotte K. Williams, Molly Morag Stevens, Min Tang
  • Patent number: 8278409
    Abstract: Copolymers exhibiting the following combinations of properties, including without limitation, ?-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: October 2, 2012
    Assignee: Ethicon, Inc.
    Inventors: Modesto Erneta, Dennis D. Jamiolkowski, Jianguo Jack Zhou, Sasa Andjelic
  • Publication number: 20110313127
    Abstract: Provided is a method for producing polylactic acid comprising the step of a ring-opening polymerization of lactide in the presence of an alkylaluminum compound represented by the following formula (1): R1nAlX3-n??Formula (1) (wherein n represents an integer of 1 to 3; R1 may be the same or different and independently represents a linear or branched alkyl group having 1 to 10 carbon atoms; X may be the same or different and independently represents a halogen atom or a hydrogen atom; and Al represents an aluminum atom) as a ring-opening polymerization catalyst. The ring-opening polymerization of lactide further effectively proceeds in the presence of at least one kind of metal compounds selected from the group consisting of aluminum compounds (except the alkylaluminum compounds represented by the above formula (1)), zinc compounds, titanium compounds, zirconium compounds, magnesium compounds, and calcium compounds.
    Type: Application
    Filed: January 29, 2010
    Publication date: December 22, 2011
    Inventors: Naruhito Iwasa, Katsuhito Miura, Yoshiro Furukawa
  • Patent number: 7884157
    Abstract: The invention concerns a process for preparing a block or comb copolymer comprising at least one hydrophilic portion and at least two hydrophobic portions, by anionic solvent-free polymerization of a prepolymer selected from a polyethylene glycol and a polyvinyl alcohol, and of a lactone or dilactone monomer. The process is carried out in the presence of an alkaline-earth metal hydride, in an inert atmosphere, and the polymerization step is not carried out under vacuum. The invention also concerns copolymers obtained by this process.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: February 8, 2011
    Assignees: Centre National de la Recherche Scientifique, Universite Montpellier 2 Sciences et Techniques
    Inventors: André Mas, Nadia Guerrouani, François Schue
  • Patent number: 7786251
    Abstract: To provide a process for producing a polyester ether poly- or mono-ol having a narrow molecular weight distribution, which is obtained by copolymerizing an initiator having hydroxyl groups with a cyclic ester compound and an alkylene oxide. It is possible to produce a polyester ether poly- or mono-ol having a molecular distribution (Mw/Mn) of from 1.02 to 1.4 by copolymerizing a cyclic ester compound which carbon number is from 3 to 9 and an alkylene oxide which carbon number is from 2 to 20 with an initiator having from 1 to 12 hydroxyl groups and having a number average molecular weight (Mn) of from 18 to 20,000 in the presence of a double-metal cyanide complex catalyst is having tert-butyl alcohol as at least a part of an organic ligand.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: August 31, 2010
    Assignee: Asahi Glass Company, Limited
    Inventors: Shigeki Uemori, Shigeru Ikai, Chitoshi Suzuki
  • Patent number: 7709593
    Abstract: Processes for feeding catalyst systems to a melt phase process for the manufacture of polyester polymers, and more particularly, to split catalyst solution feeds to the melt phase process to provide the target amount and ratio of catalyst metals.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: May 4, 2010
    Assignee: Eastman Chemical Company
    Inventor: Jason Christopher Jenkins
  • Patent number: 7553924
    Abstract: The present invention mainly relates to a carbon-carbon bond formation catalyzed by a complex comprising a novel and stable ligand and a metal center. The ligand uses a ring, particularly a phenyl group, or a hydrocarbon group to link an amino group and PR1R2, NR1R2, OR1, SR1, or AsR1R2 group for stabling the structure of the ligand.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: June 30, 2009
    Assignee: National Sun Yat-Sen University
    Inventor: Lan-Chang Liang
  • Patent number: 7537715
    Abstract: A polyamic ester (PAE) film, which shows an electro-optic (EO) and nonlinear optical (NLO) properties without a poling process, is prepared. The chromophore in the film seems to be slightly oriented normally to the film surface (transverse magnetic field (TM) direction even though the polymer solution is spin-coated. This is due to the nano-configuration structure of PAE controlled by introducing a designed chemical structure into the monomeric repeating unit of PAE. Manufacturing the relating devices can be simplified by using the self-poled polymer film as a polymer waveguide. Additionally, the EO property of the film is thermodynamically stable.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: May 26, 2009
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Seung Koo Park, Jung Jin Ju, Suntak Park, Min-su Kim, Myung-Hyun Lee
  • Patent number: 7354531
    Abstract: A composition for use as a polymer electrolyte, wherein said composition includes one or more polar materials and one or more polyesters of formula III, wherein each unit A may be identical or different and is of the structure IV, wherein each unit B may be identical or different and is of the structure V, wherein R and R1 are each, independently, hydrogen, optionally substituted hydrocarbyl or an inert functional group; a process for preparing said composition; the use of said composition as a polymer electrolyte in coulometers, displays, smart windows, cells or batteries; and a cell and/or battery having said composition.
    Type: Grant
    Filed: July 31, 2001
    Date of Patent: April 8, 2008
    Assignee: Shell Oil Company
    Inventors: Wynham Henry Boon, Thomas Clayton Forschner, David Eric Gwyn, James R. MacCallum, Christopher John Smith, Michael John Smith
  • Patent number: 7175917
    Abstract: The present invention provides a biaxially oriented film of a polylactic acid resin that is suitable for films for bags and packaging films for various windows, particularly films for outlook window envelopes. The film is biodegradable and, as films for outlook window envelopes, is superior in the coating adaptability for an antistatic agent, a lubricant and an antiblocking agent or the like and in the high-speed cutting property. The present invention discloses a biaxially oriented film of a polylactic acid resin comprising not less than 50% by weight of a polylactic acid resin, which has a storage modulus E?at 80° C. within the range from 10 MPa to 3,000 MPa, as determined by the test method for temperature dependency of dynamic viscoelasticity, in accordance with JIS K7198 (method A); a heat shrinkage of not higher than 10%, upon heating at 80° C. for 10 seconds; and a tear strength in the width direction (TD direction) of the film of 10 to 200 mN, as determined in accordance with JIS K7128 (method B).
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: February 13, 2007
    Assignee: Asahi Kasei Life & Living Corporation
    Inventors: Masayuki Sukigara, Mitsuyoshi Itada, Hisao Koike, Michihiro Yatsuzuka, Yoshiaki Hamada
  • Patent number: 7141643
    Abstract: A block copolymer is disclosed, which comprises a first block comprising polymerized units of an alkylene oxide and a second block comprising polymerized units of an alkylene oxide and a lactone, said copolymer being obtainable by polymerizing an alkylene oxide in the presence of an organic initiator to form said first block, and reacting the first block with a mixture of an alkylene oxide and a lactone. Such copolymers are found to have improved foam inhibition characteristics while maintaining their biodegradable properties.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: November 28, 2006
    Assignee: Cognis Performance Chemicals UK Ltd.
    Inventors: Elizabeth Dixon, John Robert Moxey
  • Patent number: 7135543
    Abstract: The invention relates to a polymer material having electro optic and nonlinear optical properties suitable for manufacturing a device using the electro optic and nonlinear optical properties. More particularly, the present invention relates to a polymer material having excellent electro optic properties and optical nonlinearities, maintaining the properties under the manufacturing conditions of high temperature, and having physical, chemical, and optical stabilities by introducing an organic chromophore as a side chain of the polymer so that the polymer material can be suitable for manufacturing an electro optic and nonlinear optical device, to a film manufactured from the polymer material, and to a method of manufacturing the polymer material.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: November 14, 2006
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Seung Koo Park, Jung Yun Do, Jung Jin Ju, Suntak Park, Min-Su Kim, Myung-Hyun Lee
  • Patent number: 7129319
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: October 31, 2006
    Assignee: Poly Med Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 7105629
    Abstract: The present invention includes photocurable, liquid polymers incorporating coumarin ester endgroups into their molecular structure, which polymers are crosslinked upon irradiation with ultraviolet light by photochemically allowed [2+2] cycloaddition reactions among the chain ends, and which crosslinked polymers are useful in the preparation of medical devices, tissue engineering scaffolds, drug delivery systems and, in particular, in vivo preparation of implants in an open surgical procedure or laproscopically.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: September 12, 2006
    Inventors: Takehisa Matsuda, Manabu Mizutani, Steven Arnold
  • Patent number: 7094864
    Abstract: The present invention uses a reactor that combines devices having a special portion structure to solve the difficulty of uniform blending due to the reactants becoming highly viscous, the difficulty of heat removal, and the increase in pressure loss, thus leading to continuous production of a polyester-based polymer stably having excellent quality.
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: August 22, 2006
    Assignee: Daicel Chemical Industries, Ltd.
    Inventor: Jun Watanabe
  • Patent number: 7074883
    Abstract: Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: July 11, 2006
    Assignee: Alkermes Controlled Therapeutics, Inc. II
    Inventor: Chiem V. Pham
  • Patent number: 7071288
    Abstract: The present invention is generally directed to a process for producing lactide-based polymers and the polymers produced by this process. The polymers of the present invention are terpolymers formed by the copolymerization of a lactide monomer, a linking monomer and an epoxy-terminated monomer. In one embodiment of the invention, the polymers may be formed from fluorine-containing monomers or aromatic ring-containing monomers. The disclosed materials may display improved hydrolytic and thermal characteristics as compared to previously known lactide-based materials. For example, the lactide based terpolymers may have a glass transition temperature over 60° C. For instance, lactide-based thermoplastic terpolymers of the present invention can have a glass transition temperatures of about 80° C. or higher. Lactide-based thermoset networks of the invention can have glass transition temperatures of up to about 200° C.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: July 4, 2006
    Assignee: Clemson University
    Inventors: Dennis W. Smith, Nilmini Abayasinghe
  • Patent number: 7026437
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: April 11, 2006
    Assignee: Poly-Med, INC
    Inventors: Shalaby W. Shalaby, Dan Åkerfeldt, Fredrik Preiniz, Per Egnelöv, Torbjörn Mathisen
  • Patent number: 7019106
    Abstract: A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: March 28, 2006
    Assignees: Wako Pure Chemical Industries, Ltd., Takeda Pharmaceutical Company Limited
    Inventors: Kohei Yamamoto, Tsutomu Tani, Takashi Aoki, Yoshio Hata
  • Patent number: 6911522
    Abstract: Compositions based on ?-caprolactone polymer, comprising at least one ?-caprolactone polymer and calcium carbonate. Process for preparing these compositions, which are used for manufacturing articles, in particular films, preferably obtained by extrusion blow-moulding or by flat-die extrusion.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: June 28, 2005
    Assignee: SOLVAY (Societe Anonyme)
    Inventors: Dino Manfredi, Ivan Claeys
  • Patent number: 6831149
    Abstract: The present invention is directed to a process for making an absorbable polylactone copolymer prepared in part from about 2 to about 80 mole percent glycolide, which process utilizes a combination of a monofunctional polymerization initiator and a di-functional polymerization initiator, to achieve rates of crystallization of the copolymer of at least about 2 times faster than the rate of crystallization of a copolymer made by a similar process utilizing either the mono-functional or the di-functional polymerization initiator alone. Absorbable polylactone copolymers prepared by such processes and medical devices containing such copolymers are also disclosed.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: December 14, 2004
    Assignee: Ethicon, Inc.
    Inventors: Hugh D. Newman, Jr., Sasa Andjelic, Brian M. Kelly, Dennis D. Jamiolkowski, Rao S. Bezwada
  • Patent number: 6825314
    Abstract: The object of the present invention is to provide a novel method for effectively producing a cyclic lactic acid oligomer, and a cyclic lactic acid oligomer produced by the method.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: November 30, 2004
    Assignee: Amato Pharmaceutical Products, Ltd.
    Inventors: Mikio Watanabe, Jiro Takano, Yoshimi Ishihara, Masahiro Murakami
  • Patent number: 6808907
    Abstract: The present invention provides a method for producing highly purified polyhydroxyalkanoate (PHA) with high yield, by removing cell components other than PHA from cells containing PHA. Moreover, the present invention provides a method for simply removing or reducing chlorine remained in the collected PHA particles, when a treatment with an oxidizing agent containing hypochlorite is performed in the production of PHA as described above. One of the above-described methods comprises a step of treating cells containing polyhydroxyalkanoate with an oxidizing agent containing at least hypochlorite, a step of separating the treated cells into a water-soluble fraction and a water-insoluble fraction, and a step of reducing chlorine remained in the water-insoluble fraction. The step of reducing chlorine may be a step of washing the water-insoluble fraction with a hot water, thiosulfate solution or polar solvent solution containing at least an organic polar solvent in which polyhydroxyalkanoate is insoluble.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: October 26, 2004
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tsutomu Honma, Etsuko Sugawa, Tetsuya Yano, Tsuyoshi Nomoto, Takeshi Imamura, Tomohiro Suzuki, Takashi Kenmoku
  • Patent number: 6794484
    Abstract: The present invention is directed to absorbable polylactone copolymers prepared in part from about 2 to about 80 mole percent glycolide, utilizing a combination of a monofunctional polymerization initiator and a di-functional polymerization initiator, to achieve rates of crystallization of the copolymer of at least about 2 times faster than the rate of crystallization of a copolymer made by a similar process utilizing either the mono-functional or the di-functional polymerization initiator alone. Medical devices containing such copolymers are also disclosed.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: September 21, 2004
    Assignee: Ethicon, Inc.
    Inventors: Hugh D. Newman, Jr., Sasa Andjelic, Brian M. Kelly, Dennis D. Jamiolkowski, Rao S. Bezwada
  • Patent number: 6794485
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: September 21, 2004
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
  • Patent number: 6767987
    Abstract: This invention provides a hydroxyalkyl(meth)acrylate composition modified by a small amount of lactones in which a proportion of monomers having two or more continuous chains of lactone is less than 50% (area % by GPC). This invention also provides methods for synthesizing such a composition. This invention also provides an acrylic polyol resin comprising the hydroxyalkyl(meth)acrylate composition, a carboxylic group-containing acrylate composition modified by a small amount of lactones, and a polyester unsaturated monomer modified by a small amount of lactones. Uses of these materials in curable resins, coating compositions, and finishing agents are also provided.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: July 27, 2004
    Assignee: Daicel Chemical Industries, Ltd.
    Inventor: Akira Okazaki
  • Patent number: 6703477
    Abstract: Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: March 9, 2004
    Assignee: Alkermes Controlled Therapeutics, Inc. II
    Inventor: Chiem V. Pham
  • Patent number: 6657036
    Abstract: The invention relates to polycondensation resins which are prepared by polycondensation of compounds having a low molecular weight and separation of small molecules in the presence of at least one hetergeneous catalyst. The invention also relates to polyaddition resins which are prepared by polyaddition in the presence of at least one heterogeneous catalyst. The invention further relates to the use of said polycondensation resins and polyaddition resins for the preparation of moulded parts, adhesives and coating materials.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: December 2, 2003
    Assignee: BASF Coatings AG
    Inventors: Werner-Alfons Jung, Heinz-Peter Rink, Eberhard Fuchs, Wolfgang Straehle
  • Patent number: 6642322
    Abstract: A method of making telechelic oligomers comprises reacting a substrate compound selected from the group consisting of relatively high molecular weight polymers with a chain transfer agent in the presence of an alkali metal catalyst. The telechelic oligomers thus produced may then be reacted with monomers according to known polymerization techniques in order to produce block copolymers.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: November 4, 2003
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Michel R. Gagné, Michael R. Korn
  • Patent number: 6600007
    Abstract: A bromine-containing, hydroxy-functional copolymer is prepared from an initiator that is solid at room temperature and has at least one bromone atom. The initiator is reacted with an effective amount of lactone monomers, optionally in the presence of a catalyst, to establish a bromine-containing, hydroxy-functional copolymer that is a liquid at room temperature. The copolymer of this invention may be used as liquid reactive flame retardant and, in the event the copolymer is polyfunctional, as a crosslinker.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: July 29, 2003
    Assignee: Southwest Distributing Co.
    Inventors: Herry (Z-X) Chen, Edward J. Lyszczek
  • Publication number: 20020086971
    Abstract: Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.
    Type: Application
    Filed: February 1, 2002
    Publication date: July 4, 2002
    Inventor: Chiem V. Pham
  • Patent number: 6362308
    Abstract: Copolymers of lactide and glycolide with high glycolide content. The average glycolate block length is less then about 3, which allows the copolymer to be soluble in slightly polar solvents such as methylene chloride.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: March 26, 2002
    Assignee: Alkermes Controlled Therapeutics Inc. II
    Inventor: Chiem V. Pham
  • Patent number: 6316590
    Abstract: Isotactic poly ((R)-lactic acid) or isotactic poly (S)-lactic acid are respectively prepared from (R,R)-lactide and (S,S)-lactide using a catalyst which has a zinc center or a magnesium center and two ligands where one of the ligands is a propagating group and the other of the ligands is not a propagating group. Heterotactic poly(lactic acid) is prepared from rac-lactide using a catalyst which has a zinc center and two ligands where one of the ligands is a propagating group and the other of the ligands is not a propagating group; heterotactic poly(lactic acid) is a novel composition. The catalyst with a magnesium center is a novel catalyst.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: November 13, 2001
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Geoffrey W. Coates, Ming Cheng, Bradley M. Chamberlain
  • Patent number: 6297349
    Abstract: Condensation copolymers are disclosed which are polymerized from a first monomer which is capable of polymerization by condensation polymerization, e.g., ring opening lactone polymerization, and a second monomer which is effective to suppress the crystallization of the copolymer. It is disclosed that suppression of the crystallization can provide enhanced mechanical properties in films made from the copolymers. As a result, films prepared from the copolymers of the present invention can have properties rendering them suitable for use as biodegradable trash bags as well as for other uses.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: October 2, 2001
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: Daniel Goldberg, Sandra A. Kupperblatt, Robert F. Eaton, Wong F Ark, David M Simpson
  • Patent number: 6297350
    Abstract: Copolyesters are prepared using cyclic esters or carbonates as monomers and a metallic salt of the formula Me2+X2 as catalyst. Me2+ represents Ca, Fe(II), Mg, Mn(II) or Zn, and X is an anion of an aminocarboxylic acid, hydroxycarboxylic acid or a halide. Monomer and catalyst are used in a monomer/catalyst ratio of greater than 100.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: October 2, 2001
    Assignee: Ferring GmbH
    Inventors: Hans R. Kricheldorf, Ingrid Kreiser-Saunders, Dirk-Olaf Damrau
  • Patent number: 6083729
    Abstract: Methods are provided for separating polyhydroxyalkanoates ("PHAs") from plants, such as transgenic oil crop plants. The methods advantageously permit both the oil and the PHAs to be recovered from the plant biomass. To isolate the PHAs, in one embodiment, a biomass derived from an oil crop plant is pre-processed, for example by grinding, crushing or rolling. The oil then is extracted from the biomass with a first solvent in which the oil is soluble and in which the PHAs are not highly soluble to remove the oil. The biomass then can be extracted with a second solvent in which the PHA is soluble, to separate the PHA from the biomass. Alternatively, the PHA-containing biomass is treated with a chemical or biochemical agent, such as an enzyme, to chemically transform the PHA into a PHA derivative. The PHA derivative then is separated from the mixture using, for example, a physical separation process such as distillation, extraction or chromatography.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: July 4, 2000
    Assignee: Metabolix, Inc.
    Inventors: David P. Martin, Oliver P. Peoples, Simon F. Williams
  • Patent number: 5969089
    Abstract: A bulk extrusion polymerization process to derive an aliphatic polyester from a suitable ester monomer, preferably .epsilon.-caprolactone. Novel reaction formulations containing less than 100 ppm water and having an acid value less than 0.5 mg KOH/g and preferably less than 0.2 mg KOH/g enable the polymerization of bulk monomer in an extruder in a resident time of less than 2 minutes. Different catalyst and initiator systems, processing protocols, and screw configurations lead to the preferred manufacture of poly(.epsilon.-caprolactone) polymer of number average molecular weight, M.sub.n, greater than 100,000. A novel poly(.epsilon.-caprolactone) intermediate optionally grafted to starch, is described which has significantly different processing and use characteristics as compared to a straight-chain polycaprolactone.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: October 19, 1999
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Ramani Narayan, Mohan Krishnan, Joseph B. Snook, Ajay Gupta, Philippe DuBois
  • Patent number: 5894062
    Abstract: A hydroxyalkanoic acid (PHA)is recovered from matter derived from living organisms by dissolving the PHA in a solvent which is a lower ketone, dialkyl ether or a lower alcohol or a monocarboxylic acid ester thereof, separating the solution from such matter and recovering PHA from the solution.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: April 13, 1999
    Assignee: Monsanto Company
    Inventor: John MacDonald Liddell
  • Patent number: 5821327
    Abstract: The polymerization reaction is conducted by heating a lactide, a cyclic imide compound (e.g. succinimide, etc.) and a polymerization catalyst (e.g. tin octylate, etc.) at 100-190.degree. C. with stirring under a nitrogen gas flow. It is preferred that an amount of the cyclic imide compound is from 1 to 35% by mole based on the lactide. Even if an amount of the polymerization catalyst is small, e.g. 0.00001-0.1 mole %, based on the lactide, polylactic acid can be efficiently prepared. It is possible to avoid remains of the catalyst in the polymer and coloring of the polymer.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: October 13, 1998
    Assignee: Shimadzu Corporation
    Inventors: Masaaki Oota, Masahiro Ito
  • Patent number: 5801224
    Abstract: A bulk extrusion polymerization process to derive an aliphatic polyester from a suitable ester monomer, preferably .epsilon.-caprolactone. Novel reaction formulations containing less than 100 ppm water and having an acid value less than 0.5 mg KOH/g and preferably less than 0.2 mg KOH/g enable the polymerization of bulk monomer in an extruder in a resident time of less than 2 minutes. Different catalyst and initiator systems, processing protocols, and screw configurations lead to the preferred manufacture of poly(.epsilon.-caprolactone) polymer of number average molecular weight, M.sub.n, greater than 100,000. A novel poly(.epsilon.-caprolactone) intermediate optionally grafted to starch, is described which has significantly different processing and use characteristics as compared to a straight-chain polycaprolactone.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: September 1, 1998
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Ramani Narayan, Mohan Krishnan, Joseph B. Snook, Ajay Gupta, Philippe DuBois
  • Patent number: 5747390
    Abstract: Absorbable/resorbable mixtures of aliphatic polyesters of poly(lactide), poly(glycolide), poly(trimethylene carbonate), poly(p-dioxanone) and poly(.epsilon.-caprolactone) and calcium containing bone regenerating compounds such as powdered, non-fibrous calcium phosphates are described. The composites when used to manufacture medical devices exhibit improved absorption characteristics and other physical properties.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: May 5, 1998
    Assignee: Ethicon, Inc.
    Inventors: Kevin Cooper, Chao C. Chen, Angelo Scopelianos
  • Patent number: 5679723
    Abstract: Absorbable/resorbable mixtures of aliphatic polyesters of poly(lactide), poly(glycolide), poly(trimethylene carbonate), poly(p-dioxanone) and poly(.epsilon.-caprolactone) and calcium containing bone regenerating compounds such as powdered, non-fibrous calcium phosphates are described. The composites when used to manufacture medical devices exhibit improved absorption characteristics and other physical properties.
    Type: Grant
    Filed: September 19, 1996
    Date of Patent: October 21, 1997
    Assignee: Ethicon, Inc.
    Inventors: Kevin Cooper, Chao C. Chen, Angelo Scopelianos
  • Patent number: 5646217
    Abstract: Polymer compositions are provided which comprise a first polyhydroxyalkanoate component and optionally a second polymer component, the composition have enhanced properties by using an inorganic oxygen containing compound in the composition. The inorganic oxygen containing compound may be acting as a transesterification catalyst.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: July 8, 1997
    Assignee: Zeneca Limited
    Inventor: Timothy Hammond
  • Patent number: 5614126
    Abstract: The invention relates to a substantially solventless curable resin composition, in particular for the fabrication of prepregs, which contains more than 45% by weight of substances which are solid at ambient temperature at least or at lower temperature, and which, in addition to comprising customary modifiers, comprises solid epoxy resins or a mixture of liquid and solid epoxy resins, at least one initiator which is sensitive to UV radiation for the polymerisation of the epoxy resins and has the formula I ##STR1## wherein a and b are each independently of the other 1 or 2, R.sup.1 ist a .pi.-arene, R.sup.2 is a .pi.-arene, an indenyl anion or a cyclopentadienyl anion, [X].sup..crclbar. is an anion [LQ.sub.m ].sup..crclbar.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: March 25, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Urs Gruber, Aloysius H. Manser
  • Patent number: 5525702
    Abstract: The biodegradability of polyglycol-based block copolymers is improved by including in the copolymer a lactone. Representative of these biodegradable enhanced copolymers are those made of 1,2-butylene oxide and .epsilon.-caprolactone capped with a homopolymer block of ethylene oxide. The copolymers of this invention have many uses, such as nonionic surfactants, foam control agents, lubricants, and the like.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: June 11, 1996
    Assignee: The Dow Chemical Company
    Inventor: Vaughn M. Nace
  • Patent number: 5340646
    Abstract: A breathable, hydrolyzable, porous film which is obtained by the process comprising adding from 40 to 250 parts by weight of a finely-powdered filler having an average particle size of from 0.3 to 4 .mu.m to 100 parts by weight of a polylactic acid-based resin composition comprising from 80 to 100% by weight of polylactic acid or a lactic acid-hydroxycarboxylic acid copolymer and from 0 to 20% by weight of a plasticizer, melting and film-forming the resultant mixture, and successively stretching the thus-obtained film 1.1 times or more at least in the direction of the axis; and which is consequently useful as a material for leakproof films of sanitary materials such as a paper diaper and packaging materials, and does not accumulate as wastes because of hydrolyzability in the natural environment in the case of being abandoned after use.
    Type: Grant
    Filed: April 21, 1992
    Date of Patent: August 23, 1994
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Kenji Morita, Kohichi Uchiki, Hosei Shinoda