Secretin Or Gastrin; Related Peptides Patents (Class 530/309)
  • Patent number: 4950651
    Abstract: The invention relates to new peptide derivatives of the general Formula I ##STR1## wherein R is a group derived from any oligopeptide by removing a terminal amino group, or--if the oligopeptide comprises a diamino carboxylic acid--the amino group in the .omega.-position, or the terminal and .omega.-amino groups; andstands for the integral number 1 or 2and acid addition slats thereof and a process for the preparation thereof.The new compounds of the general Formula I exhibit antitumor activity.
    Type: Grant
    Filed: April 19, 1985
    Date of Patent: August 21, 1990
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Helga Suli, Kalman Medzihradszky, Hedvig Medzihradszky nee Schweiger, Karoly Lapis, Laszlo Kopper, Andras Jeney
  • Patent number: 4840785
    Abstract: A mammal intestinal hormone precursor having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-L-M-Ala-Arg-Leu-Gl n -Arg-Leu-Leu-Gln-Gly-Leu-Val-Gly-N-O, wherein L is Glu or Asp, M is Gly or Ser, and N and O are selected from Lys and Arg; compositions containing such precursor and a method of stimulating pancreatic secretion.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: June 20, 1989
    Assignee: Kabigen AB
    Inventors: Guro Gafvelin, Mats Carlquist, Viktor Mutt
  • Patent number: 4820811
    Abstract: A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R.sup.1 and R.sup.2 are the same or different and are alkyl or hydroxy substituted alkyl containing 1 to 6 carbon atoms; andR, R' and R" are the same or different and are saturated or unsaturated aliphatics containing at least 10 carbon atoms, ##STR2## where R.sup.1, R.sup.2 and R" are as defined above, ##STR3## where R.sup.3 is independently alkyl or hydroxy substituted alkyl containing at least 10 carbon atoms; and R.sup.1, R.sup.2, R.sup.3 and R' having the meanings given above; and ##STR4## where R.sup.1, R.sup.2 and R.sup.3 have the meanings given above. The therapeutic agent is heparin, a biologically active peptide or protein or an antineoplastic drug. The therapeutic agent may also be covalently bonded to a triglyceride type backbone to form a compound.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: April 11, 1989
    Assignee: Research Corporation
    Inventor: Lin-nar L. Teng
  • Patent number: 4806336
    Abstract: A human intestinal hormone having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Le u-Gln-Arg-Leu-Gln-Gly-Leu-Val-NH.sub. 2 ; compositions containing such hormone; and a method of stimulating pancreatic secretion.
    Type: Grant
    Filed: November 7, 1986
    Date of Patent: February 21, 1989
    Assignee: KabiGen AB and Skandigen AB
    Inventors: Mats Carlquist, Hans Jornvall, Wolf-Georg Forssmann, Lars Thulin, Catja Johansson, Viktor Mutt
  • Patent number: 4760023
    Abstract: [21-Leucine] human urogastrone, hUG, comprising a polypeptide represented by the specified amino acid sequence has been found to be equivalent to the known hUG which has 21-Met and is disclosed together with its syntheses. Double-stranded polydeoxyribonucleotides comprising a structural gene for expressing the hUG, a recombinant plasmid comprising a structural gene for expressing the hUG, and E. coli transformed by the recombinant plasmid are also disclosed. Thanks to the substitution of Met in the known hUG by Leu, the peptide of hUG can now be produced by a conventional or typical method in which a genetically engineered precursor fused polypeptide is cleaved by cyanogen bromide at Met in the fused polypeptide.
    Type: Grant
    Filed: July 3, 1984
    Date of Patent: July 26, 1988
    Assignee: Wakunaga Seiyaku Kabushiki Kaisha
    Inventors: Kenichi Miyoshi, Shinichiro Sumi, Akira Hasegawa, Masanori Suzuki
  • Patent number: 4755591
    Abstract: The invention relates to a process for the preparation of protected arginine-containing peptides by fragment coupling, at least one arginine-containing fragment being reacted as perchlorate, and to protected secretin derivatives of the formula I described.
    Type: Grant
    Filed: November 28, 1986
    Date of Patent: July 5, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wolfgang Konig, Volker Teetz