Ring Formation Patents (Class 534/590)
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Patent number: 8329880Abstract: The invention relates to a process for preparing naphthalen-2-yl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.Type: GrantFiled: April 24, 2009Date of Patent: December 11, 2012Assignee: Laboratorios del Dr. Esteve, S.A.Inventors: Antoni Torrens Jover, Jordi Corbera Arjona, Maria Rosa Cuberes-Altisent
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Patent number: 8273877Abstract: Substituted tetraazapentalenes have two benzenoid rings and eight substitutable positions. Substitutions are made of hydrogen or C—H groups in favor of amino groups, nitro groups or nitrogen atoms. The tetraazapentalenes are synthesized through an intermediate azo, which is made from a 1:1:1 molar ratio of a nitroaniline, sodium nitrite and an amine.Type: GrantFiled: November 18, 2011Date of Patent: September 25, 2012Assignee: The United States of America as Represented by the Secretary of the NavyInventors: Alfred G. Stern, Patrick A. Caruana
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Patent number: 7781571Abstract: Chromophores that absorb both UV and short wavelength visible light are disclosed. The chromophores are particularly suitable for use in intraocular lens materials.Type: GrantFiled: August 7, 2008Date of Patent: August 24, 2010Assignee: Alcon, Inc.Inventors: Joseph I. Weinschenk, III, Douglas C. Schlueter, David L. Jinkerson
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Patent number: 6815550Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzoic ring, for example a trifluoromethyl group, which involves digitizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: GrantFiled: December 10, 2002Date of Patent: November 9, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Publication number: 20040039181Abstract: A process for producing amino or amido substituted aromatic azo or hydrazo compounds, or aminoaromatic amines, or aminoaromatic amides, or mixtures thereof, comprises the steps of:Type: ApplicationFiled: May 20, 2003Publication date: February 26, 2004Inventors: Roger Keranen Rains, Donald L. Fields, Ralph Dale Triplett
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Patent number: 5300659Abstract: Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anhydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.Type: GrantFiled: June 14, 1993Date of Patent: April 5, 1994Assignee: Monsanto CompanyInventors: George W. J. Fleet, Bryan G. Winchester
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Patent number: 5288858Abstract: The invention relates to azo dyes of the formula ##STR1## in which R, R.sub.1 and R.sub.2, independently of one another, are hydrogen, substituted or unsubstituted C.sub.1 -C.sub.8 alkyl or phenyl, R.sub.3 is hydrogen or substituted or unsubstituted C.sub.1 -C.sub.8 alkyl, C.sub.5 -C.sub.7 cycloalkyl or phenyl and the benzene rings I and II may be further substituted.The azo dyes are suitable for the dyeing or printing of natural or synthetic polyamide fibre materials, in particular in combination with other dyes and in particular from short liquors. The azo dyes are distinguished by generally good properties, in particular good affinity.Type: GrantFiled: July 14, 1992Date of Patent: February 22, 1994Assignee: Ciba-Geigy CorporationInventor: Jurgen Schaetzer
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Patent number: 5250703Abstract: Novel heptitol analogues of mannofuranose and their syntheses from .delta.-lactones of heptonic acids are disclosed. The novel heptitols are (A) 2,5-dideoxy-2,5-imino-D-glycero-D-talo-heptitol and (b) 1-amino-2,5-anhydro-1-deoxy-D-glycero-D-talo-heptitol. These novel heptitol compounds are useful inhibitors of glycosidases.Type: GrantFiled: September 29, 1992Date of Patent: October 5, 1993Assignee: Monsanto CompanyInventors: George W. J. Fleet, Bryan G. Winchester
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Patent number: 4835284Abstract: This invention relates to a method for preparing 2-phenylbenzotriazoles having the formula I, ##STR1##Type: GrantFiled: January 27, 1988Date of Patent: May 30, 1989Assignee: Chemipro Kasei Kaisha, Ltd.Inventor: Shuichi Seino
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Patent number: 4818815Abstract: The invention relates to novel 1,2,3-thiadiazole-axo compounds of formula ##STR1## wherein R is unsubstituted or substituted alkyl or alkenyl,R.sub.1 is hydrogen or unsubstituted or substituted alkyl or alkenyl,R.sub.2 is hydrogen or unsubstituted or substituted alkyl, alkenyl, cycloalkyl or phenyl, orR.sub.1 and R.sub.2, together with the nitrogen atom to which they are attached, are a 5- or 6-membered heterocyclic ring which may contain one or two additional hetero atoms as ring members and/or may be substituted, or R.sub.1 together with R.sub.3 ortho to the amino group form a partially hydrogenated, unsubstituted or substituted 5-or 6-membered heterocyclic ring which may contain an additional N or O atom as ring member,R.sub.3 and R.sub.4 are each independently of the other hydrogen, alkyl, alkoxy, alkanoylamino or halogen,R.sub.5 is hydrogen or together with R.sub.4 in ortho-position forms the member which completes a fused benzene ring,R.sub.7 is hydrogen, optionally substituted phenyl or alkyl, andX.Type: GrantFiled: July 17, 1986Date of Patent: April 4, 1989Assignee: Ciba-Geigy CorporationInventor: Peter Moser
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Patent number: 4628083Abstract: The invention relates to new arylazo compounds of the general formula ##STR1## wherein R.sub.1 and R.sub.2 independently of each other represent hydrogen or C.sub.1-3 alkyl, R.sub.3 represents hydrogen, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, carboxy, C.sub.1-3 alkoxycarbonyl, C.sub.1-3 alkylcarbonyl or a group X--NH--SO.sub.2 --, wherein X represents a heterocyclic ring, R.sub.4 represents hydrogen, halogen or C.sub.1-3 alkyl, and n is the integer 1 or 2, the two groups ##STR2## being the same or different when n is 2, and lactones and salts thereof. The compounds of formula I have a high inhibiting effect on prostaglandin synthetizing and inactivating enzymes and may therefore be used as a drug and anti-fertility agent. The invention also relates to preparation of the compounds of formula I as well as pharmaceutical compositions containing the same.Type: GrantFiled: January 18, 1985Date of Patent: December 9, 1986Assignee: Pharmacia ABInventor: Karl H. Agback
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Patent number: 4593109Abstract: Miticidal 1-(2-alkyl-4-(or 5)-bromo (or (chloro)-2,3-dihydrobenzofuran-7-yl)-4-alkoxy-4-alkylsemicarbazides.Type: GrantFiled: August 22, 1984Date of Patent: June 3, 1986Assignee: Shell Oil CompanyInventors: Kurt H. Pilgram, Richard D. Skiles
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Patent number: 4582898Abstract: Aniline derivatives of the formula ##STR1## wherein X=alkyl,Z=H or alkyl, andY=S-alkyl, SO.sub.2 -alkyl, CO.sub.2 -R (R=alkyl, cycloalkyl, or H) or--if Z=H--Br,are diazo components for preparing valuable azo dyestuffs and starting materials for preparing compounds of the formula ##STR2## and new azo dyestuffs derived therefrom and which--in their nonionic form--are highly suitable for dyeing polyester fibres in blue shades having high tinctorial strength and high fastness levels.Type: GrantFiled: October 12, 1984Date of Patent: April 15, 1986Assignee: Bayer AktiengesellschaftInventor: Rainer Hamprecht
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Patent number: 4581445Abstract: There are described novel cationic benzothiazole disazo compounds of the formula ##STR1## K independently of one another are each a coupling component, R independently of one another are each an unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl group,R.sub.1 independently of one another are each hydrogen, unsubstituted or substituted C.sub.1 -C.sub.4 -alkyl, unsubstituted or substituted C.sub.1 -C.sub.4 -alkoxy, or halogen,X is the direct bond, --(CH.sub.2).sub.y wherein y is a number from 1 to 4, --CH.dbd.CH--, a phenylene group, a naphthylene group, a heterocyclic radical, an --NH-alkylene-(C.sub.1 -C.sub.6)--NH-- radical or an --NH-arylene-NH-- radical, andAn is an anion, with the proviso that when the coupling component K is a dimethylaminophenyl radical, the divalent bridge member X is not the --(CH.sub.2).sub.2 -- group are useful for dyeing and printing textile materials, leather and in particular paper. The dyeings obtained have good fastness properties, especially good fastness on paper to light.Type: GrantFiled: September 16, 1983Date of Patent: April 8, 1986Assignee: Ciba-Geigy CorporationInventor: Visvanathan Ramanathan
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Patent number: 4577011Abstract: Miticidal 2-(2-alkyl-4-(or 5)-bromo (or chloro)-2,3-dihydrobenzofuran-7-yl)-N-alkoxy-N-alkyldiazenecarboxamides.Type: GrantFiled: August 22, 1984Date of Patent: March 18, 1986Assignee: Shell Oil CompanyInventors: Kurt H. Pilgram, Richard D. Skiles
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Patent number: 4568738Abstract: Thiophen-2-ylazopyrazole dyes useful for dyeing polyesters, cellulose acetate esters, and polyamides in fast yellow shades have the general formula: ##STR1## wherein: X is alkyl, allyloxy, alkoxy, aryl, aryloxy, amino, alkylamino, arylamino, cyclohexyloxy,, thienyl, cycloalkylamino, N,N-dialkylamino, or N-alkyl-N-arylamino; Y is hydrogen, alkyl, or aryl; Z is alkyl, aryl, alkylsulfonyl, 2-benzothiazolyl, cyano or COX; R and R.sub.1 are alkyl or aryl; R.sub.2 is hydrogen, alkyl, aryl, acyl, benzothiazolyl, pyridyl, sulfolanyl, quinolyl, thiocarbamyl, carbamyl, alkoxycarbonyl, aroyl, aryl-carbamyl and alkanoyl; and wherein the hydrocarbon moieties of the above radicals may be substituted with up to three of --OH, alkoxy, hydroxyalkoxy, carbamyl, and similar groups conventionally used in the azo dye art.Type: GrantFiled: March 19, 1984Date of Patent: February 4, 1986Assignee: Eastman Kodak CompanyInventors: Max A. Weaver, Clarence A. Coates, Jr.