Dextrin Or Derivative Patents (Class 536/103)
-
Publication number: 20140080936Abstract: The present invention relates to a novel polyrotaxane compound having a specific chemical structure, a photocurable coating composition that may provide a coating material having excellent mechanical properties such as scratch resistance, chemical resistance, abrasion resistance, and the like, and excellent self-healing capability, and a coating film obtained from the photocurable coating composition.Type: ApplicationFiled: September 6, 2013Publication date: March 20, 2014Applicant: LG CHEM, LTD.Inventors: Heon KIM, Yeong-Rae CHANG, Hye-Min KIM
-
Publication number: 20140066615Abstract: The present invention aims to provide a method of producing a powdered hydrophilic modified polyrotaxane, which enables production of a powdered hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way.Type: ApplicationFiled: December 5, 2011Publication date: March 6, 2014Applicants: ADVANCED SOFTMATERIALS INC., SUMITOMO SEIKA CHEMICALS CO., LTD.Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Yuki Hayashi, Minoru Iwata
-
Publication number: 20140058078Abstract: The present invention aims to provide a polyrotaxane composition having excellent storage stability. The present invention relates to a polyrotaxane composition comprising: a polyrotaxane containing a cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant.Type: ApplicationFiled: December 5, 2011Publication date: February 27, 2014Applicants: ADVANCED SOFTMATERIALS INC., SUMITOMO SEIKA CHEMICALS CO., LTD.Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Changming Zhao, Minoru Iwata, Yuki Hayashi
-
Publication number: 20140044669Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: October 17, 2013Publication date: February 13, 2014Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
-
Publication number: 20140023713Abstract: The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in ?-crystalline form, The clathrate complex may be in crystalline form, possibly in the form of nano-particles. In the clathrate complex, cyclodextrin is selected from ?-, ?-, ?- or hydroxypropyl-?-cyclodextrin, primarily ?-cyclodextrin. The proposed clathrate complexes make it possible to increase the water-solubility of the active compound, to improve the bioavailability, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cytoradioprotective activity. The invention also relates to a liquid-phase and solid-phase methods for producing clathrate complexes, as well as to pharmaceutical compositions and drugs thereof.Type: ApplicationFiled: February 20, 2012Publication date: January 23, 2014Inventors: Anatoliy Fedorovich Tsyb, Anna Yakovlevna Goncharova, Rahimdzhan Roziev, Ilya Vorobyev, Vladimir Podgorodnichenko, Kenes Erimbetov
-
Patent number: 8633172Abstract: The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissolved drug/cyclodextrin complex(es), and a solid phase of from about 10% (w/v) to about 99.9% (w/v) of the drug as solid drug/cyclodextrin particles, suspended in the aqueous phase; the size of the solid particles being from about 10 nm to about 1 mm, the drug/cyclodextrin particles being capable of dissolving in aqueous tear fluid within 24 hours of application to the eye surface. The aqueous eye suspension can be in the form of eye drops, eye gel or eye mist.Type: GrantFiled: February 4, 2013Date of Patent: January 21, 2014Assignee: Oculis EHFInventors: Thorsteinn Loftsson, Einar Stefansson
-
Publication number: 20140017674Abstract: Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.Type: ApplicationFiled: June 4, 2013Publication date: January 16, 2014Applicant: Pacific Biosciences of California, Inc.Inventors: Andrei FEDOROV, Stephen Yue, Lei Sun, Gene Shen, John Lyle
-
Publication number: 20130317209Abstract: The present invention aims to provide an industrially advantageous method of producing a pseudopolyrotaxane with a high inclusion ratio. The present invention relates to a method for producing a pseudopolyrotaxane, including: an inclusion step of mixing a polyethylene glycol and a cyclodextrin in an aqueous medium to form an aqueous dispersion of pseudopolyrotaxane that contains pseudopolyrotaxane particles in which the polyethylene glycol is included in the cavities of the cyclodextrin molecules in a skewered manner; and a drying step of drying the aqueous dispersion of pseudopolyrotaxane produced in the inclusion step to obtain the pseudopolyrotaxane. In the drying step, the aqueous dispersion of pseudopolyrotaxane is dried in a thin film state.Type: ApplicationFiled: December 5, 2011Publication date: November 28, 2013Applicants: ADVANCED SOFTMATERIALS INC., SUMITOMO SEIKA CHEMICALS CO., LTD.Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Changming Zhao
-
Publication number: 20130317208Abstract: Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., ?-cyclodextrin, ?-cyclodextrin, and ?-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.Type: ApplicationFiled: April 17, 2013Publication date: November 28, 2013Applicant: CERULEAN PHARMA INC.Inventors: J. Michael Ramstack, Thomas C. Crawford
-
Publication number: 20130316975Abstract: The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or several host molecules, using the following successive stages: (a) bringing one or several active substances into contact with one or several host molecules; (b) initiating a molecular diffusion stage by bringing a dense pressurized fluid into contact with the mixture obtained in (a) in a static mode in the presence of one or several diffusing agents; (c) recovering the active substance-host molecule molecular complex formed; (d) adding and mixing an interaction agent with the active substance-host molecule molecular complex; (e) recovering the soluble inclusion compound thus formed. The invention also relates to the soluble inclusion compound obtained by the method, particularly a piroxicam-cyclodextrin-arginine compound.Type: ApplicationFiled: April 30, 2013Publication date: November 28, 2013Applicant: PIERRE FABRE MEDICAMENTInventor: PIERRE FABRE MEDICAMENT
-
Publication number: 20130316976Abstract: The invention relates to a pharmaceutical formulation that contains a complex of a propofol salt with a cyclodextrin. The invention makes it possible to provide propofol in a formulation that can be stored and that can be administered intravenously without problems.Type: ApplicationFiled: March 1, 2012Publication date: November 28, 2013Inventors: Norbert Roewer, Jens Broscheit
-
Patent number: 8586730Abstract: The present invention discloses certain chirally correct polyene cyclodextrin acetals and hemiacetals (formula I) that are effective in providing skin clarification, which is useful for the treatment of acne, and skin disfigurements and skin darkening resulting from acne; skin darkening from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial and DNA dysfunction; age spots; loss of cellular antioxidants; skin changes associated with aging including collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles and fine lines, oxidation, damage from radiation, damage from free radicals, and damage from UV; dry skin; xerosis; ichthyosis; dandruff; brownish spots; keratoses; melasma; lentigines; liver spots; skin pigmentation including pigmented spots, dark circles under the eyes, darkened skin, and blemishes; oily skin; warts; eczema; pruritic skin; psoriasis; inflammatory dermatoses; topical inflammation; disturbed keratinization; scalp dryness, and combinations thType: GrantFiled: October 24, 2012Date of Patent: November 19, 2013Assignee: Island Kinetics Inc.Inventors: David Wayne Peter, John Dillon Stanek, Cheria L. Orozco, Shyam K. Gupta
-
Patent number: 8580140Abstract: There is provided a composition comprising (a) one or more cyclopropene complex, and (b) 0-10% water by weight based on the weight of said composition, wherein the mole ratio of cyclopropene in said composition to molecular encapsulating agent in said composition is 0.92:1 or higher, or wherein the composition is in the form of a powder and, in a two-dimensional image of a representative sample of said powder, 20% or more of the area of the images of the particles of said cyclopropene complex, based on the area of all the images of all the particles of said cyclopropene complex in said image of said sample, is in the form of particles of said cyclopropene complex that have width dimension of 10 micrometers or larger. Also provided is a process for making a composition comprising cyclopropene complex.Type: GrantFiled: March 12, 2009Date of Patent: November 12, 2013Assignee: Rohm and Haas CompanyInventors: Richard Martin Jacobson, Philip John Ranly
-
Publication number: 20130296547Abstract: The present invention aims to provide an industrially advantageous method for producing an aqueous dispersion of pseudopolyrotaxane enabling to produce an aqueous dispersion of pseudopolyrotaxane having good fluidity and excellent dispersion stability of the pseudopolyrotaxane particles therein. The present invention relates to a method for producing an aqueous dispersion of pseudopolyrotaxane. The method includes: a mixing step of a dissolving polyethylene glycol and a cyclodextrin in an aqueous medium to prepare a mixed solution; and a cooling step of continuously or intermittently cooling the mixed solution in a state of flux to precipitate pseudopolyrotaxane particles. The pseudopolyrotaxane particles contain the polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner.Type: ApplicationFiled: December 5, 2011Publication date: November 7, 2013Applicants: ADVANCED SOFTMATERIALS INC., SUMITOMO SEIKA CHEMICALS CO., LTD.Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Changming Zhao
-
Publication number: 20130296546Abstract: The present invention aims to provide an industrially advantageous method of producing a powdery pseudopolyrotaxane with a high inclusion ratio. The present invention relates to a method for producing a pseudopolyrotaxane, including: an inclusion step of mixing a polyethylene glycol and a cyclodextrin in an aqueous medium to form an aqueous dispersion of pseudopolyrotaxane that contains pseudopolyrotaxane particles in which the polyethylene glycol is included in the cavities of the cyclodextrin molecules in a skewered manner; and a drying step of drying the aqueous dispersion of pseudopolyrotaxane produced in the inclusion step to obtain the pseudopolyrotaxane. In the drying step, the aqueous dispersion of pseudopolyrotaxane is sprayed and dried in a heated gas-stream.Type: ApplicationFiled: December 5, 2011Publication date: November 7, 2013Applicants: ADVANCED SOFTMATERIALS INC., SUMITOMO SEIKA CHEMICALS CO., LTD.Inventors: Tomoaki Yamasaki, Shinya Okazaki, Hiroki Okazaki, Shigeki Hamamoto, Changming Zhao
-
Publication number: 20130288054Abstract: A particulate SAE-CD composition is provided. The SAE-CD composition has an advantageous combination of physical properties not found in known solid forms of SAE-CD. In particular, the SAE-CD composition possesses an advantageous physicochemical and morphological property profile such that it can be tailored to particular uses. The SAE-CD composition of the invention has improved flow and dissolution performance as compared to known compositions of SAE-CD.Type: ApplicationFiled: March 11, 2013Publication date: October 31, 2013Inventor: CyDex Pharmaceuticals, Inc.
-
Patent number: 8568815Abstract: A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.Type: GrantFiled: August 16, 2010Date of Patent: October 29, 2013Assignee: Novobion OyInventor: Jaakko Parkkinen
-
Patent number: 8512758Abstract: A powder composition, includes: (A) an oil-soluble antioxidant substance powder; (B) a water-soluble antioxidant substance powder; and (C) at least one of zinc, selenium, manganese and copper.Type: GrantFiled: September 3, 2008Date of Patent: August 20, 2013Assignee: FUJIFILM CorporationInventor: Fumitaka Ueda
-
Publication number: 20130211068Abstract: According to one embodiment, there is provided a composition for use in making a cured binder, the composition comprising: a first mixture comprising citric acid and an alkali metal hydroxide or an aqueous solution comprising the reaction products thereof; wherein the molar ratio of the alkali metal hydroxide to citric acid is between about 0.001:1 to 0.6:1, and wherein the pH of the first mixture is about 0.5 to about 2.5 when the first mixture is a 50% by weight citric acid aqueous solution.Type: ApplicationFiled: October 8, 2010Publication date: August 15, 2013Inventors: Kevin R. Anderson, Larry Todd Banner, Shuang Zhou
-
Patent number: 8507665Abstract: A reactive cyclodextrin derivative or a reactive glucose derivative is used as a template derivative for forming an ultra-low dielectric layer. A layer is formed of the reactive cyclodextrin derivative or the reactive glucose derivative capped with Si—H and then cured in an atmosphere of hydrogen peroxide to form the ultra-low dielectric layer.Type: GrantFiled: May 18, 2012Date of Patent: August 13, 2013Assignee: Hynix Semiconductor Inc.Inventors: Sung Kyu Min, Ja Chun Ku, Sang Tae Ahn, Chai O Chung, Hyeon Ju An, Hyo Seok Lee, Eun Jeong Kim, Chan Bae Kim
-
Publication number: 20130199007Abstract: The present invention relates to a method to improve the appearance of a corpse by means of the application of specific thanatocosmetic compositions. The invention also relates to the new compositions and to their use in thanato-aesthetics.Type: ApplicationFiled: February 2, 2012Publication date: August 8, 2013Inventor: Astrid LOMBARDI
-
Publication number: 20130197105Abstract: An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.Type: ApplicationFiled: March 11, 2013Publication date: August 1, 2013Applicant: CyDex Pharmaceuticals, Inc.Inventor: CyDex Pharmaceuticals, Inc.
-
Publication number: 20130196948Abstract: Described herein are inventive compositions and methods relating to polymer conjugates and, in particular, to polymer conjugates having pendant side groups comprising ring moieties. In one aspect, embodiments are generally related to compositions that mimic naturally-occurring polyphenol compounds. The compositions comprise, in some embodiments, a polymer backbone having a plurality of hydroxyaromatic pendant side groups or derivatives thereof. For example, in some cases, a pendant side group may be a phenol or a substituted derivative thereof. In some cases, the pendant side group may be an oxidized hydroxyaromatic group, such as a quinone. In some embodiments, self-assembled structures comprising one or more of the polymer conjugates are provided. For example, the polymer conjugates may be combined with a complexing agent to form a particle. In some cases, a polymer conjugate may form a hydrogel.Type: ApplicationFiled: June 23, 2011Publication date: August 1, 2013Applicant: MASSACHUSETTS INSITUTE OF TECHNOLOGYInventors: Omar Fisher, Christopher G. Levins, Robert S. Langer, Daniel Griffith Anderson
-
Patent number: 8497320Abstract: A process is provided by which a polyrotaxane including cyclic molecules having a relatively long graft chain is easily obtained. Also provided is a polyrotaxane which includes cyclic molecules having a radical polymerization initiation site and is for use as a raw material in the process. The polyrotaxane comprises: a pseudo-polyrotaxane comprising cyclic molecules clathrated with a linear molecule, the cavities of the cyclic molecules having been pierced by the linear molecule; and blocking groups disposed respectively at both ends of the pseudo-polyrotaxane so as not to release the cyclic molecules. The cyclic molecules in the polyrotaxane have a radical polymerization initiation site.Type: GrantFiled: May 7, 2009Date of Patent: July 30, 2013Assignee: Advanced Softmaterials Inc.Inventors: Christian Ruslim, Mariko Suzuki
-
Publication number: 20130190450Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: August 10, 2012Publication date: July 25, 2013Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
-
Patent number: 8492538Abstract: Chiral salts comprising anionic cyclodextrin derivatives with particular types of non-metal cations are provided. The anionic CD derivative salts can serve as ionic liquids and can possess substantial advantages over currently commercially available ionic liquids particularly for use as chiral phase transfer catalyst, chiral reaction medium, chiral extraction medium, and/or as chiral additive to a chemical process. Methods of preparing the same are provided.Type: GrantFiled: June 2, 2010Date of Patent: July 23, 2013Inventor: Jose R. Matos
-
Publication number: 20130184357Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.Type: ApplicationFiled: March 7, 2013Publication date: July 18, 2013Applicant: CyDex Pharmaceuticals, Inc.Inventor: CyDex Pharmaceuticals, Inc.
-
Publication number: 20130184453Abstract: Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.Type: ApplicationFiled: August 15, 2012Publication date: July 18, 2013Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Mark E. Davis, Hector Gonzalez, Suzie (Sue Jean) Hwang
-
COMPOUND HAVING DETRUSOR MUSCLE-CONTRACTING ACTIVITY AND URETHRAL SPHINCTER MUSCLE-RELAXING ACTIVITY
Publication number: 20130184236Abstract: Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a diastereomer thereof in an arbitrary ratio, or a cyclodextrin clathrate thereof have a contracting activity of bladder detrusor and a relaxing activity of urethral sphincter, they can ameliorate bladder contraction dysfunction and/or urethral relaxation dysfunction, and for example, are effective for underactive bladder. Additionally, the compound of the present invention has little risk of side effects on the urinary system, the circulatory system and the digestive system, and exhibits excellent pharmacokinetics, such as oral absorbability etc. Therefore, the compound of the present invention is useful as a superior agent for preventing, treating and/or ameliorating underactive bladder.Type: ApplicationFiled: March 4, 2013Publication date: July 18, 2013Applicant: ONO PHARMACEUTICAL CO., LTD.Inventor: ONO PHARMACEUTICAL CO., LTD. -
Patent number: 8481716Abstract: The invention relates to a process for the preparation of a cyclodextrin/alpha-lipoic acid complex, wherein in a first step, an alpha-lipoic acid and a cyclodextrin are dissolved in an aqueous alkaline solution having a pH above pH 7, and in a second step an acid is added to lower the pH of the solution to a pH below pH 7.Type: GrantFiled: April 28, 2010Date of Patent: July 9, 2013Assignee: Wacker Chemie AGInventors: Helmut Reuscher, Mark Bauer
-
Publication number: 20130172545Abstract: A superhydrophilic amphiphilic copolymer and process for making the superhydrophilic amphiphilic copolymer includes a low molecular weight polysaccharide modified with a hydrophobic reagent, such as substituted succinic anhydride. The superhydrophilic amphiphilic copolymer system generates stable foam for use in applications, such as healthcare formulations, with low irritation of the eyes and skin.Type: ApplicationFiled: February 25, 2013Publication date: July 4, 2013Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventor: Akzo Nobel Chemicals International B.V.
-
Publication number: 20130172291Abstract: The present invention discloses certain polyene cyclodextrin acetals and hemiacetals that are effective in providing skin clarification, which is useful for the treatment of acne, and skin disfigurements and skin darkening resulting from acne; skin darkening from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial and DNA dysfunction; age spots; loss of cellular antioxidants; skin changes associated with aging including collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles and fine lines, oxidation, damage from radiation, damage from free radicals, and damage from UV; dry skin; xerosis; ichthyosis; dandruff; brownish spots; keratoses; melasma; lentigines; liver spots; skin pigmentation including pigmented spots, dark circles under the eyes, darkened skin, and blemishes; oily skin; warts; eczema; pruritic skin; psoriasis; inflammatory dermatoses; topical inflammation; disturbed keratinization; scalp dryness, and combinations thereof.Type: ApplicationFiled: February 14, 2013Publication date: July 4, 2013Applicant: ISLAND KINETICS INC.Inventor: ISLAND KINETICS INC.
-
Patent number: 8466278Abstract: This invention relates to novel ?-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are useful as active ingredients for the treatment and/or prophylaxis of degenerative joint diseases, osteoarthritis, articular rheumatism, arthrosis or degenerative arthritis, or for the treatment of heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.Type: GrantFiled: September 22, 2009Date of Patent: June 18, 2013Assignee: Arcarios B.V.Inventors: Dirk Elewaut, August Lodewijk Verbruggen
-
Patent number: 8455464Abstract: A composition for the treatment of adhesions that are formed as a result of an inflammatory response comprising an aqueous formulation containing the polysaccharide dextrin in an effective amount. The invention also discloses a method of treating adhesions that are formed as a result of an inflammatory response.Type: GrantFiled: January 19, 2001Date of Patent: June 4, 2013Assignee: Innovata LimitedInventor: Susan Conroy
-
Publication number: 20130136769Abstract: Compositions and methods for providing infant nutrition with partially hydrolysed proteins and non-digestible oligosaccharides for use in induction of oral tolerance against native dietary proteins.Type: ApplicationFiled: June 1, 2011Publication date: May 30, 2013Inventors: Léon Mathieu Johannes Knippels, Elisabeth Catharina Adriana Maria Van Esch, Johan Garssen
-
Patent number: 8450415Abstract: It is intended to provide a crosslinked polyrotaxane formed by crosslinking polyrotaxane molecules via chemical bonds which exhibits excellent optical properties in water or in an aqueous solution of sodium chloride; a compound having this crosslinked polyrotaxane; and a process for producing the same. The above object can be achieved by a crosslinked polyrotaxane having at least two polyrotaxane molecules, wherein linear molecules are included in a skewered-like state at the opening of cyclodextrin molecules and blocking groups are provided at both ends of the linear molecules, so as to prevent the cyclodextrin molecules from leaving, and cyclodextrin molecules in at least two polyrotaxane molecules being bonded to each other via chemical bond, characterized in that hydroxyl (—OH) groups in the cyclodextrin molecules are partly substituted with non-ionic groups.Type: GrantFiled: January 11, 2005Date of Patent: May 28, 2013Assignee: The University of TokyoInventors: Kohzo Ito, Masatoshi Kidowaki, Yuzo Sakurai, Changming Zhao
-
Publication number: 20130129665Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: January 11, 2013Publication date: May 23, 2013Applicant: CERULEAN PHARMA INC.Inventor: Cerulean Pharma Inc.
-
Patent number: 8445460Abstract: The invention relates to soluble, highly branched glucose polymers which are obtained by enzymatic treatment of starch, having a reducing sugars content of less than 3.5%, exhibiting a proportion of ?-1,6-glucosidic linkages of between 20% and 30%, a Mw, determined by light scattering, of between 20·103 and 30·103 daltons, and an osmolality of less than 25 mOsm/kg. The invention likewise relates to a method of obtaining these polymers and to their use in the pharmaceutical and food industries, more particularly in the field of enteral and parenteral nutrition, and in the field of peritoneal dialysis.Type: GrantFiled: February 15, 2007Date of Patent: May 21, 2013Assignee: Roquette FreresInventors: Laëtitia Deremaux, Carole Petitjean, Daniel Wills
-
Patent number: 8440814Abstract: The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, R1 is an OH group, all R1 s are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n=1, m=6, Z=NH2 and R1=OH is excluded.Type: GrantFiled: May 19, 2009Date of Patent: May 14, 2013Assignees: Centre National de la Recherche Scientifique, Universite Joseph Fourier, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de SevillaInventors: Jacques Defaye, Carmen Ortiz-Mellet, Jose Manuel Garcia-Fernandez, Maria Gomez-Garcia, Kazimierz Chmurski, Jian-Xin Yu
-
Publication number: 20130101545Abstract: The present invention provides a novel compound for counteracting amine-based malodor in consumer, industrial and textile products.Type: ApplicationFiled: October 18, 2012Publication date: April 25, 2013Applicant: International Flavors & Fragrances Inc.Inventor: International Flavors & Fragrances Inc.
-
Publication number: 20130072673Abstract: The present invention discloses certain chirally correct polyene cyclodextrin acetals and hemiacetals (formula I) that are effective in providing skin clarification, which is useful for the treatment of acne, and skin disfigurements and skin darkening resulting from acne; skin darkening from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial and DNA dysfunction; age spots; loss of cellular antioxidants; skin changes associated with aging including collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles and fine lines, oxidation, damage from radiation, damage from free radicals, and damage from UV; dry skin; xerosis; ichthyosis; dandruff; brownish spots; keratoses; melasma; lentigines; liver spots; skin pigmentation including pigmented spots, dark circles under the eyes, darkened skin, and blemishes; oily skin; warts; eczema; pruritic skin; psoriasis; inflammatory dermatoses; topical inflammation; disturbed keratinization; scalp dryness, and combinations thType: ApplicationFiled: October 24, 2012Publication date: March 21, 2013Applicant: ISLAND KINETICS INCInventor: ISLAND KINETICS INC
-
Publication number: 20130046087Abstract: The present invention relates to substituted cyclodextrin derivatives which are particularly useful intermediates for producing well-defined carboxyalkylated cyclodextrins in contrast with the poorly-defined mixtures available through prior art procedures. The present invention also relates to processes for their preparation in a limited number of steps. These well-defined carboxyalkylated cyclodextrins can be polysulfated according to procedures standard in the art and some of these polysulfates, and alkali salts thereof, have been found to exhibit biologically active properties especially for the treatment and/or prophylaxis of degenerative joint diseases (e.g. osteoarthritis) or heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.Type: ApplicationFiled: March 23, 2011Publication date: February 21, 2013Applicant: Arcarios BVInventors: Serge Van Calenbergh, Kiran Toti, Eric Wilhelmus Petrus Damen
-
Publication number: 20130040518Abstract: The present invention relates to a method for functionalizing a solid material surface with self assembling or self aggregating cyclodextrins, said method comprising the steps of: providing an adsorption solution comprising at least one modified cyclodextrins and at least one solvent; and contacting a solid material surface with the adsorption solution.Type: ApplicationFiled: April 20, 2011Publication date: February 14, 2013Applicant: AALBORG UNIVERSITETInventors: Kim Lambertsen Larsen, Ronnie Nielsen, Karen Østergaard Styrbæk
-
Patent number: 8372933Abstract: Hyperbranched, water-soluble polymers, obtainable by Michael polyaddition of ?-, ?-, or ?-cyclodextrins and amines to bisacrylamides.Type: GrantFiled: June 10, 2008Date of Patent: February 12, 2013Assignee: L'Urederra Fundacion Para el Desarrollo Tecnologico y SocialInventors: Paolo Ferruti, Elisabetta Ranucci, Francesco Trotta, Roberta Cavalli, Claudio Fernandez
-
Publication number: 20130029936Abstract: The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-?-cyclodextrin or sulfobutylether-7-?-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.Type: ApplicationFiled: March 7, 2012Publication date: January 31, 2013Inventors: Jae Hyun Kim, Su Kyung Lee, Won Kyu Choi, Jong Lae Lim, Soon Kil Ahn, Hee Jong Shin, Chung Il Hong
-
Publication number: 20130030167Abstract: A method for producing digestion-resistant dextrin from starch hydrolyzates is disclosed. In one form, the method includes mixing the starch hydrolyzate, dextrose and an acid catalyst which are allowed to react under mild vacuum with heat. The ingredients require no pre-drying and the method requires no external plasticizers.Type: ApplicationFiled: July 26, 2011Publication date: January 31, 2013Applicant: Grain Processing CorporationInventors: Lin Wang, Perminus Mungara
-
Publication number: 20130017198Abstract: A novel mechanism by which after-depolarization occurs in cardiac myocytes has been discovered, involving calcium influx through the arachidonate-regulated calcium channel (ARCC) and the store-operated calcium channel (SOCC). Because after-depolarization of the myocyte is a major cause of cardiac arrhythmia, this discovery provides new approaches for treating and preventing heart disease. By down-regulating the activity of the ARCC or the SOCC, after-depolarization can be decreased and cardiac arrhythmia can be prevented, reduced, or eliminated. This can be accomplished using pharmaceuticals containing inhibitors of the ARCC or the SOCC, or by genetically modifying cells to reduce ARCC or SOCC activity. In addition, assays are disclosed using the ARCC or SOCC to discover potential anti-arrhythmic agents. Cellular and animal models of arrhythmia are disclosed in which the activity of the ARCC or SOCC is increased to promote after-depolarization and induce arrhythmia.Type: ApplicationFiled: March 25, 2011Publication date: January 17, 2013Applicant: THE UAB RESEARCH FOUNDATIONInventors: Paul Wolkowicz, Jian Huang
-
Publication number: 20130018164Abstract: The present invention relates to a novel method for synthesizing a composition of polymers, copolymers, terpolymers and tetrapolymers, and to the use thereof, said composition being made from: cyclodextrins, in particular ?-cyclodextrin, ?-cyclodextrin, ?-cyclodextrin, the derivatives thereof or the corresponding mixtures thereof; and/or calix[n]arene(s) and/or calix[n]arene derivative(s) and/or a mixture of two or more different calix[n]arenes selected from calix[n]arenes (n=4-20) and/or the derivatives thereof, and to the uses thereof. A method was developed on the basis of bulk polycondensation by heating. The invention can be used in the pharmaceutical, human medicine, veterinary medicine, chemistry, separation chemistry, environmental, electronics, biology, diagnostics, phytosanitation, medicinal food, agri-food, and cosmetics fields, and in the nutraceutical field and in the field of molecular imprints (MIP).Type: ApplicationFiled: December 27, 2010Publication date: January 17, 2013Inventor: Mohamed Skiba
-
Patent number: 8354350Abstract: A reactive cyclodextrin derivative or a reactive glucose derivative is used as a template derivative for forming an ultra-low dielectric layer. A layer is formed of the reactive cyclodextrin derivative or the reactive glucose derivative capped with Si—H and then cured in an atmosphere of hydrogen peroxide to form the ultra-low dielectric layer.Type: GrantFiled: May 18, 2012Date of Patent: January 15, 2013Assignee: Hynix Semiconductor Inc.Inventors: Sung Kyu Min, Ja Chun Ku, Sang Tae Ahn, Chai O Chung, Hyeon Ju An, Hyo Seok Lee, Eun Jeong Kim, Chan Bae Kim
-
Patent number: RE44733Abstract: Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6)alkylene, optionally substituated with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p—; o and p are independently 0-4; X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2—CH2—O)q—H, OH or tetrazol-5-yl; R1 is H or (C1-3)alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.Type: GrantFiled: March 28, 2012Date of Patent: January 28, 2014Assignee: Merck Sharp & Dohme B.V.Inventors: Mingiang Zhang, Ronald Palin, Jonathan Bennett