Chitin Or Derivative Patents (Class 536/20)
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Publication number: 20140045218Abstract: A surfactant produced by reacting naturally occurring polysaccharides that are not water soluble with a hydrophilic substituent on a carboxylic portion of the polysaccharide. In a second reaction, the surfactant is further substituted on a hydroxylic portion with a hydrophobic or lipophilic substituent, so as to make the reaction product both water soluble and capable of attracting oily material that is hydrophobic to be removed from a substrate by cleaning in water. Methods of making the surfactant and the follow-on reaction product are described.Type: ApplicationFiled: March 15, 2013Publication date: February 13, 2014Applicant: University of MassachusettsInventors: Zarif Farhana Mohd Aris, Ryan M. Bouldin, Ramaswamy Nagarajan, Bridgette Budhlall, Vishal Bavishi
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Publication number: 20140039039Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.Type: ApplicationFiled: October 15, 2013Publication date: February 6, 2014Applicant: NOVARTIS AGInventors: Gregory HINKLE, Satyanarayana KUCHIMANCHI, Stuart MILSTEIN, Markus WARMUTH, Wenlai ZHOU, Ping ZHU, Tracy S. ZIMMERMANN
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Publication number: 20140027938Abstract: Disclosed are methods for electrospinning chitinous biomass solution to form chitin fibers, using ionic liquids or other ion-containing liquids as solvent. Chitin fibers produced thereby and articles containing such chitin fibers are also disclosed. The chitin fiber thus obtained has very high surface area and improved strength over currently commercially available chitin materials.Type: ApplicationFiled: July 24, 2013Publication date: January 30, 2014Applicant: Board of Trustees of The University of AlabamaInventors: Richard P. Swatloski, Patrick S. Barber, Terrance Opichka, Jonathan R. Bonner, Gabriela Gurau, Christopher Scott Griggs, Robin D. Rogers
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Patent number: 8629252Abstract: Non-crosslinked derivatives of oligo/polysaccharides of formula wherein: X is OH, O?M, NH—R1, O—R1; M is an alkaline or alkaline-earth metal, transition metal, or cation containing a quaternary nitrogen atom; Y is H or R2; R1: the residue of an oligo/polysaccharide; R2: the residue of a C1-C4 linear chain aliphatic carboxylic acid or citric acid; provided that at least one X is NH—R1 or O—R1, while the other two X are present in acid (OH) or salified form (OM).Type: GrantFiled: December 18, 2007Date of Patent: January 14, 2014Assignee: Sigea S.R.L.Inventors: Marco Bosco, Luca Stucchi, Fabrizio Picotti, Rita Gianni
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Patent number: 8628593Abstract: The process described in the instant invention has the steps of dissolving the lipid-containing biomass in an ionic liquid, whereby a lipid phase and a hydrophilic phase are formed. The lipid phase contains primarily triglycerides, which can be converted to biodiesel by transesterification to, e.g., methyl esters. The hydrophilic phase comprises dissolved biopolymers, such as cellulose, hemicellulose, and protein. The biopolymers are converted in situ to compounds that are insoluble in the molten inorganic salt hydrate. The molten inorganic salt hydrates regenerated by removing insolubles, such as lignin, ash from the biomass, and water.Type: GrantFiled: February 18, 2011Date of Patent: January 14, 2014Assignee: BOleCON International Holding N.V.Inventors: Jacob A. Moulijn, Sjoerd Daamen, Paul O'Connor, Rob Van Der Meij
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Patent number: 8617132Abstract: The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.Type: GrantFiled: October 6, 2010Date of Patent: December 31, 2013Assignee: Regents of the University of MinnesotaInventors: Jafar Golzarian, Lihui Weng
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Publication number: 20130345168Abstract: The present invention relates to a composition for preventing skin aging containing chitooligosaccharides as an active ingredient. The invention provides a cosmetic composition for preventing skin aging caused by UV rays containing chitooligosaccharides of 1-3 kDa, 3-5 kDa or 5-10 kDa molecular weight as an active ingredient.Type: ApplicationFiled: April 29, 2011Publication date: December 26, 2013Applicant: PUKYONG NATIONAL UNIVERSITY INDUSTRY UNIVERSITY COOPERATION FOUNDATIONInventors: Se-Kwon Kim, Chang-Suk Kong, Soon-Sun Bak, Jung-Ae Kim, Byul-Nim Ahn
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Publication number: 20130338245Abstract: A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing.Type: ApplicationFiled: May 20, 2013Publication date: December 19, 2013Applicant: LIFE TECHNOLOGIES CORPORATIONInventor: Matthew BAKER
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Publication number: 20130331557Abstract: A method for producing chitosan from naturally occurring chitin-containing raw material, such as crustacean shells, includes an optional pretreatment step to remove non-chitin rich organic material for example, shrimp flesh, from the raw material, e.g., shrimp shells. The optional pretreatment is followed by a demineralization step utilizing a mild hydrochloric acid solution and a deproteination step utilizing a mild sodium hydroxide solution. The deproteination step is followed by a deacetylation step to remove the acetyl group from N-acetylglucosamine (chitin) to form an amine group, yielding d-glucosamine (chitosan). Each step is followed by a washing step and the product is dried, preferably at a temperature not in excess of about 65° C. Known purification and grinding steps may also be used to produce the final chitosan product. The process is carried out in equipment comprising a series of substantially identical or similar tanks (18, 26, 36, etc.) and dryers (62, 62?), suitably interconnected.Type: ApplicationFiled: November 26, 2012Publication date: December 12, 2013Applicant: AGRATECH INTERNATIONAL, INC.Inventor: AGRATECH INTERNATIONAL, INC.
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Publication number: 20130316892Abstract: Provided are polymer particles which can be used at a high flow rate when used as a filler for chromatography, that is, has excellent resistance flow rate appropriate for processing in large quantities, and also has a high binding capacity for target molecules such as proteins when an appropriate ligand is contained in the particles, and a method for producing the polymer particles; specifically, crosslinked polymer particles and a method for producing the crosslinked polymer particles, polysaccharide composite particles and a method for producing the polysaccharide composite particles, a filler for chromatography using the polymer particles, and an adsorbent for antibody purification. Disclosed are: A.Type: ApplicationFiled: December 14, 2011Publication date: November 28, 2013Applicant: JSR CorporationInventors: Satoshi Nakamura, Tetsuo Fukuta, Kazuhiro Ikkyu, Yu Otani, Hiroshi Kawai
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Publication number: 20130317178Abstract: A polymer includes at least one pendant dioxirane moiety represented by Formula III or IV: In Formulas III and IV, R1 is absent or is alkylene, perhaloalkylene, cycloalkylene, arylene, heteroarylene, heterocyclylene, amino, carbonyl, carboxyl, alkylcarboxy, carboxyalkyl or alkylcarboxyalkyl; R2 is an electron withdrawing group; R8 is —N+R4R5 or alkylene; R9 is —N+R4R5 or alkylene; each R4 is independently H, alkyl, or cycloalkyl; and each R5 is independently H, alkyl, or cycloalkyl.Type: ApplicationFiled: August 1, 2013Publication date: November 28, 2013Applicant: Empire Technology Development LLCInventors: Angele Sjong, Kraig K. Anderson
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Publication number: 20130303705Abstract: Novel, crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels and in antimicrobial compositions.Type: ApplicationFiled: July 16, 2013Publication date: November 14, 2013Inventors: MARK ALLEN ANDREWS, Garret D. Figuly, Henry Keith Chenault
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Publication number: 20130303480Abstract: This disclosure relates generally to soft tissue augmentation threads, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.Type: ApplicationFiled: October 13, 2011Publication date: November 14, 2013Inventors: Kenneth N. Horne, Jayakumar Rajadas, Geoffrey C. Gurtner, Naveen Jayakumar
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Publication number: 20130292337Abstract: Disclosed is a water-insoluble polymeric iron chelating agent having a polymer backbone and an aromatic ring attached to the polymer backbone through an —NH—CH2— bond, wherein the aromatic ring has one or two first functional groups in the form of hydroxyl group and one or two second functional groups located at the ortho position with respect to the first functional group; and wherein the second functional group is —OH, —COOH, or a group represented by formula (I) wherein A represents —CH3, —CH2—CH3, —CH2—C6H5, —CH2—C5H4N or —CH2—COOH and B represents —CH2—COOH. The water-insoluble polymeric iron chelating agent of the present invention offers the advantages of being capable of selectively chelating iron ions, particularly biologically unstable iron, and being insoluble in water, and moreover not being incorporated in metabolic processes in vivo.Type: ApplicationFiled: January 12, 2012Publication date: November 7, 2013Applicants: National University Corporation ASAHIKAWA MEDICAL UNIVERSITY, DISEASE ADSORPTION SYSTEM TECHNOLOGIES CO., LTD.Inventors: Yuzo Nishida, Yutaka Kohgo, Katsuya Ikuta, Katsunori Sasaki
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Publication number: 20130288932Abstract: According to an embodiment, a method of providing a biopolymer comprises: cryodesiccating a broth, wherein the broth comprises: (A) a biopolymer, wherein the biopolymer is an exopolysaccharide; and (B) a liquid growth medium. According to certain embodiments, the biopolymer is produced by the fermentation of at least one carbohydrate via a microbe. According to an embodiment, the microbe is a bacterium. According to another embodiment, the microbe is a fungus.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicant: HALLIBURTON ENERGY SERVICES, INC.Inventors: Andrew A.F. Mackenzie, Eric Davidson
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Patent number: 8557125Abstract: A coagulant composition includes chitosan, methacryloyloxyethyltrimethyl ammonium methyl sulfate and a redox initiator. A coagulant, method for making the coagulant and clarifying wastewater is also provided.Type: GrantFiled: June 7, 2010Date of Patent: October 15, 2013Assignee: General Electric CompanyInventors: Seethalakshmi Suresh, Stephen Robert Vasconcellos, Narain Madhavan, Baraka Kawawa
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Publication number: 20130266953Abstract: Provided herein are fluorescent bioprobes comprising fluorogens that exhibit aggregation-induced emission (AIE) labeled on biomolecules. The present subject matter relates to a fluorescent bioprobe comprising one or more fluorogen labeled on chitosan. The present subject matter is also directed to methods of preparing the fluorescent bioprobes, methods of labeling and detecting DNA and/or proteins with the fluorescent bioprobe, and methods of cell imaging including live cell tracking.Type: ApplicationFiled: May 21, 2013Publication date: October 10, 2013Applicant: The Hong Kong University of Science And TechnologyInventor: The Hong Kong University of Science And Technology
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Patent number: 8552164Abstract: The invention relates to a novel method for production of nanofibrillar chitin, sustainable from an industrial manufacturing standpoint and suitable for producing chitin nanofibrils having improved properties and free from less crystalline components. The invention also relates to novel chitin nanofibrils obtained with said method and characterized by an increased dispersibility in aqueous media. The invention further relates to uses of nanofibrils in pastes and aqueous gels useful for topical on-skin application, to the manufacturing of materials of biomedical interest, as well as to the deposition of chitin nanofibrils on coating surfaces or the incorporation of the same inside of items like, e.g., fibers and fabrics of any Origin, natural as well as synthetic or mixed ones.Type: GrantFiled: November 23, 2006Date of Patent: October 8, 2013Assignee: Mavi Sud S.r.l.Inventors: Pierfrancesco Morganti, Corrado Muzzarelli
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Publication number: 20130244974Abstract: A composition suitable for use in wound healing, particularly for reducing post-surgical adhesions, containing cross-linked derivatives of chitosan and dextran polymers. A hydrogel forms when solutions of the polymers are combined.Type: ApplicationFiled: May 3, 2013Publication date: September 19, 2013Applicant: Medtronic Xomed, Inc.Inventors: Theodore Athanasiadis, Lyall Robert Hanton, Stephen Carl Moratti, Brian Harford Robinson, Simon Rae Robinson, Zheng Shi, James Simpson, Peter John Wormald
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Patent number: 8530632Abstract: Body tissue and structures may be protected using a fluid containing a mixture of partially crosslinked polysaccharide and a further crosslinker. The mixture desirably is sprayable, forms a fluid protective layer via in situ crosslinking, desirably does not drip or run from a treatment site, and may avoid the use of more rapidly curing but potentially less bioacceptable crosslinkers at the treatment site.Type: GrantFiled: April 23, 2009Date of Patent: September 10, 2013Assignee: Medtronic Xomed, Inc.Inventors: Edze Jan Tijsma, Maria Nieves Gonzalez, Matthew Franco Myntti, Brian Vaccaro
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Publication number: 20130227747Abstract: Described is an antigen-binding protein, preferably comprising an amino acid sequence that comprises four framework regions and three complementarity-determining regions, wherein the antigen-binding protein is capable of binding a chitinous polysaccharide, and uses thereof.Type: ApplicationFiled: August 26, 2011Publication date: August 29, 2013Inventors: Peter Verheesen, Chris De Jonghe, Erik Jongedijk
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Patent number: 8518267Abstract: Clarification of surfactant laden wastewaters of the type commonly encountered in the laundry, dishwashing, textile manufacturing, and metal cleaning and degreasing processes is provided by use of a chitosan/(meth)acrylyloxy alkyl quaternary ammonium salt graft polymer.Type: GrantFiled: December 15, 2011Date of Patent: August 27, 2013Assignee: General Electric CompanyInventors: Stephen Robert Vasconcellos, Matthew D. Mersch, James Quentin Pollett
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Publication number: 20130199993Abstract: The present invention discloses a method of preparing a functional chitosan scaffold and said functional chitosan scaffold for use as a filtering medium. Said method involves freeze-drying chitosan in the presence of appropriate cross-linkers and additives. The present chitosan scaffold is associated with an increased mechanical strength and elasticity and an adjustable surface polarity, porosity and morphology which enable its use in a wide range of devices, equipments and appliances in need of a filtering medium such as air or water purification system.Type: ApplicationFiled: January 14, 2013Publication date: August 8, 2013Applicant: NANO AND ADVANCED MATERIALS INSTITUTE LIMITEDInventor: NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
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Publication number: 20130200008Abstract: Methods for preparing a chitosan-based material for use in a halogen water treatment system are described. Treating chitosan or chitin with a compound selected from the group consisting of an acid, a base, a mild halogenating solution and combinations thereof provides a chitosan-based material that displays reduced leakage of halide ion. Water treatment systems and methods for treating water comprising at least one contaminant are also described.Type: ApplicationFiled: February 6, 2013Publication date: August 8, 2013Applicant: WATER SECURITY CORPORATIONInventor: WATER SECURITY CORPORATION
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Patent number: 8501919Abstract: The configuration of a feedstock material is controlled by bringing it into contact with at least a first gas moving against it at a location with an area and thickness of the feedstock liquid that forms drops or fibers of a selected size. In one embodiment, drops of agricultural input materials are formed for spraying on agricultural fields. In another embodiment, nanofibers of materials such as chitosan or metals are formed. In another embodiment seeds are planted with gel.Type: GrantFiled: November 13, 2007Date of Patent: August 6, 2013Assignee: Kamterer Products, LLCInventors: John Alvin Eastin, David Vu
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Publication number: 20130197205Abstract: The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (?4?1) and alpha-V-beta-3 (?V?3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.Type: ApplicationFiled: January 24, 2013Publication date: August 1, 2013Applicant: Hoffmann-La Roche Inc.Inventor: Hoffmann-La Roche Inc.
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Publication number: 20130190267Abstract: Tissue adhesives formed by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Applicant: Actamax Surgical Materials, LLCInventor: Actamax Surgical Materials, LLC
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Publication number: 20130190227Abstract: Described herein are methods of inhibiting the growth of or killing a bacterium in an animal subject, preventing or delaying onset of an infection with a bacterium in an animal subject, preventing or delaying onset of a pathogen mediated disease or disorder in an animal subject, or reducing bacterial load in an animal subject, comprising administering an effective amount of a derivatized chitosan to the animal. Also described herein are preparations comprising a chitosan derivative for administration to an animal.Type: ApplicationFiled: March 12, 2013Publication date: July 25, 2013Applicant: SYNEDGEN, INC.Inventor: SYNEDGEN, INC.
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Publication number: 20130172288Abstract: A process for the simultaneous substitution and crosslinking of a polysaccharide via its hydroxyl functional groups, in an aqueous phase, which includes the following steps: a polysaccharide is placed in an aqueous medium, it is brought into the presence of at least one precursor of a substituent, it is brought into the presence of a crosslinking agent, the substituted and crosslinked polysaccharide is obtained and isolated, wherein process is carried out in the presence of a basic or acidic catalyst, the concentration of which is between 3.16×10?7 and 0.32 mol/L, and at a temperature of less than 60° C. In one embodiment, the polysaccharide is in the form of a gel or hydrogel which is used in particular as augmentation biomaterial.Type: ApplicationFiled: December 3, 2012Publication date: July 4, 2013Applicant: LABORATOIRES VIVACYInventor: LABORATOIRES VIVACY
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Publication number: 20130164311Abstract: A composition of exceptionally dense chitosan and a novel method for producing the dense chitosan structure have been described. The novel production method employs coincident compression and vacuum on a neutralized chitosan polymer that results in an exceptionally dense chitosan film or membrane material. The dense chitosan film or membrane composition possesses multiple physical and clinically appealing qualities for a variety of medical applications on or in animals, mammals, or humans.Type: ApplicationFiled: December 22, 2011Publication date: June 27, 2013Applicant: Agenta Biotechnologies Inc.Inventors: Arthur A. DeCarlo, April Ellis, Thomas P. Dooley, Maria Belousova
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Patent number: 8466127Abstract: The present invention provides a PEGylated and fatty acid grafted chitosan oligosaccharide comprising a structural unit represented by the following Formula (I) and a structural unit represented by the following Formula (II) and synthesize method, wherein the chitosan oligosaccharide has a molecular weight of less than 200,000 Da, and a degree of deacetylation of 70%-100%, and part of free amino groups of chitosan oligosaccharide chain are replaced by a fatty acid or PEG, where n refers to degree of polymerization of the PEG, and R is an alkyl group having 11-21 carbon atoms. The grafting ratio of fatty acids is 1%-50%, and the grafting ratio of PEG is 0.05%-50%. The present invention also comprise a pharmaceutical composition comprising the PEGylated and fatty acid grafted chitosan oligosaccharide as a carrier, and use of the PEGylated and fatty acid grafted chitosan oligosaccharide in preparation of a pharmaceutical composition.Type: GrantFiled: June 16, 2009Date of Patent: June 18, 2013Assignee: Zhejiang UniversityInventors: Fuqiang Hu, Yongzhong Du, Hong Yuan, Pan Meng
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Publication number: 20130145958Abstract: It is an object of the present invention to provide a spinning solution for industrial production of pure chitosan fiber and the method for fabricating the same. The method comprises the steps of: step (a): screening a flake chitosan raw material and removing impurities; step (b): putting in a dissolving kettle the screened flake chitosan raw material with a weight which is 3%-8% of the total weight of the spinning solution, sealing the dissolving kettle, and evacuating into vacuum; step (c): adding 0.9%-6% acetic acid solution, and soaking at the room temperature for 40-60 minutes; step (d): uniformly stirring at a rate of 26-60 rpm for 7.5-19 hours under a pressure of ?5000 pa in the dissolving kettle, standing for 1-3 hours, and obtaining a spinning solution.Type: ApplicationFiled: March 24, 2011Publication date: June 13, 2013Applicant: SHANDONG HUAXING HAICI NEW MATERIALS CO., LTD.Inventors: Jiacun Zhou, Guangmin Hu
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Patent number: 8460897Abstract: The fungus Irpex lacteus is efficiently cultured on a solid substrate with a high content of crystalline cellulose. The fungal culture can be used to produce cellulases that are useful in conversion of cellulose to sugars. The fungal culture can also be used to produce chitin, which is itself valuable and can also be converted to chitosan. Use of the fungal culture for co-production of cellulases and chitin is also described.Type: GrantFiled: December 16, 2010Date of Patent: June 11, 2013Assignee: Eclipse Bioproducts, LLCInventors: Eugene N. Bernat, David Scott Hibbett, Dimitrios Floudas
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Publication number: 20130129710Abstract: The invention discloses a method for producing a hemostatic composition comprising mixing a biocompatible polymer suitable for use in hemostasis and a genipin-type crosslinker, crosslinking said polymer by said genipin-type crosslinker to obtain a crosslinked biocompatible polymer, and finishing said crosslinks polymer to a pharmaceutically acceptable hemostatic composition, new hemostatic compositions and methods for using such compositions.Type: ApplicationFiled: October 25, 2012Publication date: May 23, 2013Applicants: Baxter Healthcare S.A., Baxter International Inc.Inventors: Baxter International Inc., Baxter Healthcare S.A.
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Publication number: 20130130398Abstract: Methods, compositions, and systems for detecting explosives is disclosed and described. A sensor for detecting explosives can comprise a porous hydrophilic material modified with a titanium oxo compound having the following structure (I) where L is a ligand. Additionally, the porous hydrophilic material can be capable of detecting hydrogen peroxide vapor by complexing the titanium oxo compound and the hydrogen peroxide to provide a color change.Type: ApplicationFiled: November 19, 2010Publication date: May 23, 2013Applicant: University of UtahInventor: Ling Zang
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Patent number: 8445465Abstract: The present invention relates to a glycol chitosane derivative, a preparation method thereof and a drug delivery system comprising the same. More specifically, the invention relates to a glycol chitosan derivative, which can form nano-sized self-assembled structures and has both temperature sensitivity and biodegradability so as to be suitable for use as a drug delivery system, as well as a preparation method thereof and a drug delivery system comprising the same.Type: GrantFiled: December 21, 2010Date of Patent: May 21, 2013Assignee: Chungnam National University Collaboration FoundationInventors: Kang Moo Huh, Zheng Zheng Li
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Publication number: 20130115252Abstract: A method of preparing genipin-rich materials from the fruit of Genipa americana fruit for their use as a cross-linking agent and as a raw material to produce colors is disclosed. The genipin-rich materials can be used in a broad range of applications including personal care, cosmetics, dietary supplements, packaging, textiles, beverages, foodstuffs, drugs, and animal feeds.Type: ApplicationFiled: November 7, 2012Publication date: May 9, 2013Applicant: Wild Flavors, Inc.Inventor: Wild Flavors, Inc.
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Publication number: 20130098550Abstract: A method for adhering a medical device to biological tissue includes adhering an adhesive composition having a plurality of reactive members of a specific binding pair to tissue which has a plurality of complementary reactive members of the specific binding pair via click chemistry.Type: ApplicationFiled: March 24, 2011Publication date: April 25, 2013Applicant: COVIDIEN LPInventors: Tim Sargeant, Robert Ahmad Hadba, Joshua Stopek
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Publication number: 20130096262Abstract: A compound includes a polymer where the polymer includes a pendant dioxirane moiety. Cost-effective, facilitated generation of a polymer including a pendant dioxirane moiety allows for the compound to be disposable or be easily recycled. The compound can be used in air purification and liquid purification to not only remove particulate matter, but also to destroy microorganisms and remove volatile organic compounds.Type: ApplicationFiled: April 12, 2012Publication date: April 18, 2013Inventors: Angele Sjong, Kraig Anderson
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Patent number: 8420802Abstract: The invention provides a polymer support characterized in that the polymer is 6-amino 6-deoxy chitosan. Metal-immobilized 6-amino 6-deoxy chitosan is further provided, more particularly including one of Pd, Pt, Ru, Rh Ir, Os, Mn, Ni, Co and Fe in all their possible oxidation states complexed to 6-amino 6-deoxy chitosan through a Schiff-base ligand.Type: GrantFiled: September 14, 2010Date of Patent: April 16, 2013Assignee: University of Cape TownInventors: Moegamat Anwar Jardine, Gregory Stuart Smith, Banothile Charity Events Makhubela
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Patent number: 8420781Abstract: An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can be obtained by the maximum excitation. The present invention provides a novel fluorescent protein monomerized by introducing a mutation into a florescent protein derived from Fungia sp., and a novel chromoprotein and fluorescent protein derived from Montipora. sp.Type: GrantFiled: August 2, 2011Date of Patent: April 16, 2013Assignees: Riken, Medical & Biological Laboratories Co., Ltd.Inventors: Atsushi Miyawaki, Takako Kogure, Hiroshi Hama, Masataka Kinjo, Kenta Saito, Satoshi Karasawa, Toshio Araki
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Publication number: 20130090306Abstract: The present invention pertains to chitosan beads consisting of chitosan cross-linked with citrate ions. The present invention furthermore pertains to a filler comprising such chitosan-citrate beads. In one embodiment of the instant invention the filler is a dermal filler. In one further embodiment of the present invention the dermal filler is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler is for use in the treatment of a medical condition. The filler provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler as claimed herein.Type: ApplicationFiled: April 7, 2011Publication date: April 11, 2013Applicant: MERZ PHARMA GmbH & CO. KGaAInventors: Kevin Kiehm, Bernhard Hauptmeier, Peter Boderke
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Publication number: 20130079504Abstract: A mixture of a raw material poorly water-soluble polysaccharide or derivative thereof in an ionic liquid-containing solvent is exposed to radiation. Accordingly, a polysaccharide gel producing process is provided that can produce a gel without performing a special pretreatment for the raw material.Type: ApplicationFiled: September 25, 2012Publication date: March 28, 2013Applicant: JAPAN ATOMIC ENERGY AGENCYInventor: JAPAN ATOMIC ENERGY AGENCY
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Patent number: 8399635Abstract: Described herein are methods of inhibiting the growth of or killing a bacterium in an animal subject, preventing or delaying onset of an infection with a bacterium in an animal subject, preventing or delaying onset of a pathogen mediated disease or disorder in an animal subject, or reducing bacterial load in an animal subject, comprising administering an effective amount of a derivatized chitosan to the animal. Also described herein are preparations comprising a chitosan derivative for administration to an animal.Type: GrantFiled: November 12, 2009Date of Patent: March 19, 2013Assignee: Synedgen, Inc.Inventors: Shenda Baker, William P. Wiesmann
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Patent number: 8383787Abstract: This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.Type: GrantFiled: February 22, 2011Date of Patent: February 26, 2013Assignee: Yissum Research Development CompanyInventor: Saul Yedgar
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Patent number: 8383157Abstract: The invention relates to novel chitin derivatives and their use in medical treatments of plastic surgery, dermocosmesis and therapy, in particular it relates to natural chitin derivatives, like chitin in nanofibrillar form, oxychitin and other chemical derivatives of chitin, chitosan-hyaluronate and associations for use as subcutaneous fillers or skin protectants.Type: GrantFiled: November 2, 2005Date of Patent: February 26, 2013Assignee: Mavi Sud S.r.l.Inventors: Corrado Muzzarelli, Pierfrancesco Morganti
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Patent number: 8377418Abstract: The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.Type: GrantFiled: September 11, 2008Date of Patent: February 19, 2013Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Joseph Fourier-Grenoble 1Inventors: Rachel Auzely-Velty, Caroline Creuzet
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Publication number: 20130039822Abstract: Microporous glutaraldehyde-crosslinked chitosan sorbents, methods of making and using them, and a generator for the radioisotope 99Mo containing the sorbents.Type: ApplicationFiled: March 19, 2012Publication date: February 14, 2013Applicant: Perma-Fix Environmental Services, Inc.Inventor: Shameem HASAN
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Publication number: 20130041407Abstract: A fluid-swellable fiber in particular for the use as a surgical suture, the fiber comprising chitosan, the fiber's swelling ratio being less than 100%, and a fabric comprising the fiber. Moreover, a method of manufacturing from a chitosan-containing solution a fiber comprising chitosan, wherein during manufacture, the solution is brought into contact with a coagulation medium containing at least one organic solvent, a method of removing a fiber from a living organism, wherein the fiber is at least partly dissolved in a solvent applied from the outside, and a kit comprising a chitosan containing fiber and a solvent for at least partly dissolving the fiber.Type: ApplicationFiled: February 2, 2010Publication date: February 14, 2013Applicant: MEDOVENT GMBHInventors: Rivelino Montenegro, Thomas Freier
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Publication number: 20130029934Abstract: The present invention relates to novel silyl-derivatives of polysaccharides and their salts, the processes for their preparation and their use in cosmetic/pharmaceutical field.Type: ApplicationFiled: March 4, 2011Publication date: January 31, 2013Inventors: Gaspare Aita, Demetrio Manenti, Pasqualino Rossi, Giuseppe Rosano