Additional Hetero Ring Containing Patents (Class 540/222)
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Publication number: 20090192306Abstract: The present invention relates to cephalosporin of formula (I) in crystalline form. The compound of formula (I) in crystalline form is useful as antibiotics having potent and broad antibacterial activity; especially against methicillin resistant Staphylococci (MRSA) and Pseudomonas aeruginosa.Type: ApplicationFiled: April 1, 2009Publication date: July 30, 2009Inventor: Joerg Berghausen
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Patent number: 7553962Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.Type: GrantFiled: August 24, 2007Date of Patent: June 30, 2009Assignee: Theravance, Inc.Inventors: Paul R. Fatheree, Martin S. Linsell, Daniel Marquess, S. Derek Turner
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Publication number: 20090131394Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.Type: ApplicationFiled: October 9, 2008Publication date: May 21, 2009Inventors: Larry Sutton, Sophia Yu
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Patent number: 7531650Abstract: The present invention relates to cephalosporin of formula (I) in crystalline form. The compound of formula (I) in crystalline form is useful as antibiotics having potent and broad antibacterial activity; especially against methicillin resistant Staphylococci (MRSA) and Pseudomonas aeruginosa.Type: GrantFiled: March 15, 2004Date of Patent: May 12, 2009Assignee: Basilea Pharmaceutica AGInventor: Joerg Berghausen
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Publication number: 20090082325Abstract: The present invention discloses a novel powder for oral suspension of cefdinir. Also disclosed are methods of preparing the suspension and methods of treatment using the suspension.Type: ApplicationFiled: November 28, 2008Publication date: March 26, 2009Applicant: Abbott LaboratoriesInventor: Chetan P. Pujara
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Patent number: 7507813Abstract: A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is implemented by means of antisolvent recrystallization to prepare the cefuroxime axetil in an amorphous form; particularly, the amorphous ultrafine or even nanosized cefuroxime axetil with a controllable particle size and a narrow particle size distribution. The cefuroxime axetil according to the invention can used to enhance bioavailability, since it is in an amorphous form and has a controllable particle size and a narrow particle size distribution.Type: GrantFiled: July 22, 2005Date of Patent: March 24, 2009Assignees: Nanomaterials Technology Pte Ltd., Beijing University of Chemical TechnologyInventors: Jianfeng Chen, Jie Zhong, Zhigang Shen, Jiyao Zhang
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Publication number: 20090047692Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a ?-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a ?-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a ?-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a ?-lactmase or instructions for using the components in an assay.Type: ApplicationFiled: April 7, 2008Publication date: February 19, 2009Applicant: INVITROGEN CORPORATIONInventors: Schuyler Boon CORRY, William Louis Downey, Brian Filanoski, Kyle Richard Gee, I. Lawrence Greenfield, James David Hirsch, Iain Johnson, Aleksey Rukavishnikov
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Patent number: 7488724Abstract: The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ?-lactamase enzymes, for enhancing the activity of ?-lactam antibiotics, and for treating ?-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula (I), and intermediates useful for the synthesis of compounds of formula (I).Type: GrantFiled: May 10, 2005Date of Patent: February 10, 2009Assignee: Southern Methodist University Foundation for ResearchInventors: John D. Buynak, Lakshminarayana Vogeti
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Publication number: 20090036672Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are as defined in the description and methods for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.Type: ApplicationFiled: July 29, 2008Publication date: February 5, 2009Applicant: ANTIBIOTICOS S.p.A.Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
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Patent number: 7479556Abstract: Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.Type: GrantFiled: September 9, 2005Date of Patent: January 20, 2009Assignee: ACS Dobfar S.p.A.Inventors: Antonio Manca, Riccardo Monguzzi, Maurizio Zenoni, Leonardo Marsili
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Publication number: 20080306256Abstract: The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n=0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II).Type: ApplicationFiled: July 4, 2005Publication date: December 11, 2008Applicant: Orchid Chemicals & Pharmaceuticals LimitedInventors: Udayampalayam P. Senthilkumar, Venu S. Lakshmipathi, Gnanaprakasam Andrew, Ramasubbu Chandrasekaran, Dindigala Nagender Rao, Gaddam Om Reddy
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Patent number: 7452990Abstract: A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics wherein X is chlorine or bromine; R is hydrogen, C1-4 alkyl group, an easily removable hydroxyl protective group, —CH2COOR5, or —C(CH3)2COOR5, wherein R5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV1), wherein X, R and R5 are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII) in an organic solvent at a temperature ranging from ?30° C. to ?15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.Type: GrantFiled: December 26, 2002Date of Patent: November 18, 2008Assignee: Lupin LimitedInventors: Debashish Datta, Muralikrishna Dantu, Brijkishore Mishra, Pollepeddi Lakshmi Narayana Sharma
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Publication number: 20080262219Abstract: A novel crystal (B-type crystal) of 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (a syn isomer) , characterized in that it exhibits peaks at diffraction angles shown in the following Table 1, in its powder X ray diffraction pattern: TABLE 1 Diffraction Angle 2? (°) approximately 11.7 approximately 16.1 approximately 18.6 approximately 21.2 approximately 22.3 approximately 24.4 approximately 26.2 This crystal is obtained by forming a crystal from a solution at a temperature of ?5 to 5° C. in an acidic state. The crystal is not bulky, exhibits good stability and good filterability, and is excellent in the solubility toward water, and thus can be prepared with case.Type: ApplicationFiled: April 30, 2008Publication date: October 23, 2008Inventors: Eiji Imai, Niwa Hiroyuki
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Publication number: 20080242858Abstract: There is provided an improved process for preparing cefixime. Thus, for example, 7-amino-3-vinyl-3-cephem-4-carboxylic acid is reacted with 2-mercapto-1,3-benzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-(methoxycarbonyl)-methoxyimino acetate in tetrahydrofuran and water at 4° C. in the presence of triethylamine. The reaction mass is extracted with ethyl acetate. 7-[2-(2-Amino-4-thiazolyl)-2-(methoxycarbonylmethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid triethylamine salt present in the aqueous layer is hydrolyzed with sodium hydroxide in less than 30 minutes and aqueous hydrochloric acid is added immediately to adjust the pH to 4.8 to 5.2. Then, aqueous hydrochloric acid is added at 35° C. to adjust the pH 2.5 and cooled to crystallize cefixime trihydrate in high purity.Type: ApplicationFiled: March 29, 2005Publication date: October 2, 2008Applicant: HETERO DRUGS LIMITEDInventors: Bandi Parthasaradhi, Kura Rathnakar, Rapolu Raji Reddy, Dasari Muralidhara, Nagabelli Murali
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Patent number: 7427680Abstract: Fluorescent substrates for beta-lactamases having the general formula shown above are provided. Z includes a fluorophore or chromophore and includes a group that may link to the lactam-containing group; R1 and R2 are independently selected from H, aliphatic, aromatic, alkyl, and acyl; R4 may be H and lower alkyl; B may be H, physiologically acceptable salts or metal, ester groups, ammonium cations, —CHR5OCO(CH2)nCH3, —CHR5OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benz, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R5 is selected from the group consisting of H and lower alkyl; n is an integer between 0 and 10, inclusive; and A may be S, O, SO, SO2 or CH2. In embodiments, the beta-lactam ring may be cleaved by a beta-lactamase enzyme effective to free a fluorophore.Type: GrantFiled: July 2, 2004Date of Patent: September 23, 2008Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Jianghong Rao
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Publication number: 20080221076Abstract: The present invention relates to novel polymorph of Ceftiofur sodium as a crystalline product. The present invention also provides a process for the preparation of crystalline Ceftiofur sodium of formula (I).Type: ApplicationFiled: October 12, 2006Publication date: September 11, 2008Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITEDInventors: Udayampalayam Palanisamy Senthilkumar, Kanagaraj Suresh Kumar, Singaravel Mohan, Lakshminarayanan Arunkumar, Bakthavachalam Ananthan
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Patent number: 7405294Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are defined in the description. These salts are useful intermediates for the preparation of cefdinir. Also, disclosed are processes for the preparation thereof from the compounds of the general formula (II) and (III). Further, disclosed is a method of producing cefdinir from the salts of the general formula (I) including the steps of removing protecting groups.Type: GrantFiled: September 26, 2003Date of Patent: July 29, 2008Assignee: Antibioticos S.p.A.Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
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Publication number: 20080167270Abstract: The invention is related to phosphorus substituted anti-infective compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: September 20, 2007Publication date: July 10, 2008Inventors: Constantine G. Boojamra, Aesop Cho, William J. Watkins
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Patent number: 7396926Abstract: Provided are fluorescent substrates for ?-lactamases having the general formula I: in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R? is selected from the group consisting of H, physiologically acceptable salts or metal, ester groups, ammonium cations, —CHR2OCO(CH2)nCH3, —CHR2OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, ?-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Z is a donor fluorescent moiety. Also provided are methods of use of the compound of general formula I.Type: GrantFiled: January 11, 2002Date of Patent: July 8, 2008Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Jianghong Rao
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Patent number: 7384928Abstract: A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: March 18, 2003Date of Patent: June 10, 2008Assignee: Shionogi & Co., Ltd.Inventors: Yasuhiro Nishitani, Yoshinori Yamano
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Publication number: 20080114164Abstract: The present invention relates to compounds of formula (I) and a process for producing the same. In formula (I), X represents a halogen atom, and R1 represents group —COR2 wherein R2 represents group OM or C1-12 alkyloxy wherein M represents a hydrogen atom, an alkali metal, an alkaline earth metal, or quaternary ammonium. The use of this compound as a synthetic intermediate can realize the production of carbapenem derivatives having potent antimicrobial activity in an efficient and safe manner at low cost.Type: ApplicationFiled: January 19, 2006Publication date: May 15, 2008Inventors: Eiki Shitara, Kunio Atsumi, Keiichi Ajito, Shinya Ikeda, Tadashi Katoh, Munenori Inoue, Mari Nakatani
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Patent number: 7355040Abstract: There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclizing a compound of Formula (III): wherein R1, R2, R3, R4, X and m have meanings which are given in the description.Type: GrantFiled: November 22, 2004Date of Patent: April 8, 2008Inventors: Desmond John Best, George Burton, Brian Charles Gasson, Neal Frederick Osborne, Graham Walker
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Patent number: 7339055Abstract: A process for the preparation of cephalosporin antibiotic of the formula (I) which comprises: (i) activating the compound of formula (III) as acid halide in an organic solvent (ii) treating the reaction mass obtained from step (i) with water (iii) separating the organic layer containing the reactive derivative of formula (III) and condensing it with 7-amino cephalosporin derivative by maintaining the pH in the range 5.0-10.0 using an inorganic base of the formula (XV), and iv) cyclizing the compound of formula (XVI) with thiourea in the presence of solvent and salt of organic or inorganic acid at a temperature in the range of ?50 to +50° C. to produce compound of formula (I).Type: GrantFiled: August 23, 2004Date of Patent: March 4, 2008Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Deshpande, Udayampalayam Palanisamy Senthilkumar, Velladurai Hero
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Publication number: 20070213313Abstract: An amino acid in solution is precipitated with concentrated hydrochloric acid and isolated as the dihydrochloride monohydrate. Said dihydrochloride is redissolved and reprecipitated by adding a solvent.Type: ApplicationFiled: August 17, 2006Publication date: September 13, 2007Applicant: Harvest Lodge LimitedInventors: Maurizio Zenoni, Mauro Filippi
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Publication number: 20070208173Abstract: Crystalline hydrates of (6R-(6?,7?(Z))-7-((2-amino-4-thiazolyl)(hydroxyimino)acetyl)amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (cefdinir), calcium salt, ways to make them, compositions comprising them and made with them, and methods of treatment using them are disclosed.Type: ApplicationFiled: March 1, 2007Publication date: September 6, 2007Inventors: Ron Christopher Kelly, Jeffrey Scott Stults
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Patent number: 7250508Abstract: 7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetamido]-3-vinyl-cephem-4-carboxylic acid of formula I in the form of a crystalline salt and use thereof, e.g. in the preparation of pure cefdinir. In another aspect this invention relates to the compound of formula I in the form of a salt, optionally in crystalline form, wherein the salt is selected from the group consisting of phosphate, hydrogen phosphate, mesylate, tosylate, sulfate, hydrogen sulfate and sulfamate.Type: GrantFiled: August 12, 2003Date of Patent: July 31, 2007Assignee: Sandoz AGInventors: Peter Kremminger, Siegfried Wolf, Johannes Ludescher
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Patent number: 7244842Abstract: A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a tertiary amine and an organic solvent, followed by treatment with a base to produce a salt of compound formula (XIV), wherein M+ is a counter ion and ii) hydrolyzing the compound of the formula (XIV) using an acid in the presence of a solvent to produce cefdinir of formula (I).Type: GrantFiled: November 10, 2003Date of Patent: July 17, 2007Assignee: Orchid Chemicals & Pharmaceuticals Ltd.Inventors: Pandurang Balwant Desphande, Bhausaheb Pandharinath Khadangale, Chandrasekaran Ramasubbu
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Patent number: 7192943Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: GrantFiled: September 17, 2004Date of Patent: March 20, 2007Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.Inventors: Toshio Yamanaka, Kenji Murano, Ayako Toda, Hidenori Ohki, Masaru Oogaki, Shinya Okuda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Sato
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Patent number: 7179801Abstract: The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R3 and R5 are independently amino or protected amino; and R4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: GrantFiled: April 24, 2002Date of Patent: February 20, 2007Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., Ltd.Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Hitomi Ogino, legal representative, Tetsuya Ogino, legal representative, Tomomi Takezawa, legal representative, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Hisashi Akamatsu, Kenji Satoh, Takashi Ogino, deceased
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Patent number: 7173126Abstract: Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatment with phosphoric acid.Type: GrantFiled: December 1, 2003Date of Patent: February 6, 2007Assignee: Antibioticos S.p.A.Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
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Patent number: 7157575Abstract: Substrates for ?-lactamase of the general formula I in which one of X and Y is a fluorescent donor moiety and the other is a quencher (which may or may not re-emit); R? is selected from the group consisting of H, lower (i.e., alkyl of 1 to about 5 carbon atoms) and (CH2)nOH, in which n is 0 or an integer from 1 to 5; R? is selected from the group consisting of H, physiologically acceptable metal and ammonium cations, —CHR2OCO(CH2)nCH3, —CHR2OCOC(CH3)3, acylthiomethyl, acyloxy-alpha-benzyl, delta-butyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, beta-morpholinoethyl, dialkylaminoethyl, acyloxyalkyl, dialkylaminocarbonyloxymethyl and aliphatic, in which R2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO2 and CH2; and Z? and Z? are linkers for the fluorescent donor and quencher moieties.Type: GrantFiled: October 24, 2002Date of Patent: January 2, 2007Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Gregor Zlokarnik
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Patent number: 7157576Abstract: High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a crystalline salt of a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdinir and reacting the crystalline salt with a base in a solvent.Type: GrantFiled: June 5, 2002Date of Patent: January 2, 2007Assignee: Hanmi Pharm. Co., Ltd.Inventors: Gwan-Sun Lee, Young-Kil Chang, Hong-Sun Kim, Chul-Hyun Park, Gha-Seung Park, Cheol-Kyung Kim
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Patent number: 7129232Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: GrantFiled: October 30, 2003Date of Patent: October 31, 2006Assignees: Astellas Pharma Inc., Wakunaga Pharmaceutical Co., LtdInventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Masaru Ohgaki, Ayako Toda, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Kenji Satoh
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Patent number: 7112672Abstract: A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephem compound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; R1 is hydrogen or R2CH2CO—; and R2 is ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxyType: GrantFiled: April 17, 2002Date of Patent: September 26, 2006Assignee: Hanmi Pharm. Co., Ltd.Inventors: Gwan-Sun Lee, Young-Kil Chang, Hong-Sun Kim, Jae-Heon Lee, Chul-Hyun Park, Gha-Seung Park, Cheol-Kyung Kim
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Patent number: 7105659Abstract: The present invention relates to a novel process for the preparation of a cefdinir by reacting O-acetyl thioester of Formula I with in the presence of a base in suitable solvent wherein R? represents H or any carboxyl protecting group, and then converting to the cefdinir by the removal of protecting groups. This invention also relates to making the cefdinir using a novel process to prepare the O-acetyl thioester intermediate (Formula I) by condensing (Z)-2-(2-amino-4-thiazolyl)-2-acetyloxyiminoacetic acid with bis(benzothiazol-2-yl)disulphide in the presence of triphenylphosphine and a base in a suitable solvent.Type: GrantFiled: October 1, 2003Date of Patent: September 12, 2006Assignee: Aurobind - Pharma Ltd.Inventors: Ramesh Dandala, V. V. Prasada Rao Korrapati, Meenakhshisunderam Sivakumaran
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Patent number: 7071329Abstract: Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein: Z is benzathine; and X and R2 are as defined in the specification, is reacted with thiourea. The resulting product may be crystallized as a sodium salt, as an internal salt, or as a pharmaceutically acceptable salt.Type: GrantFiled: August 12, 2004Date of Patent: July 4, 2006Assignee: ACS Dobfar S.p.A.Inventors: Riccardo Monguzzi, Antonio Manca, Leonardo Marsili, Maurizio Zenoni
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Patent number: 7064199Abstract: The invention is concerned with a process for the manufacture of vinylpyrrolidinone-cephalosporin derivatives from 3-amino-pyrrolidine derivatives of the formula wherein R1 signifies hydrogen or an amino protecting group; Z signifies hydrogen or an amino protecting group; and * represents a center of chirality.Type: GrantFiled: December 22, 2003Date of Patent: June 20, 2006Assignee: Basilea Pharmaceutica AGInventors: Marc Muller, Milan Soukup
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Patent number: 7064198Abstract: A process for preparation of cefuroxime axetil of formula (I) of at least 96% purity and substantially free of analogous ?2-isomer of formula (II) and other impurities. The process comprises reacting cefuroxime acid of formula (III) with (R,S)-1-acetoxyethyl bromide of formula (IV), and a Group I or II metal carbonate in the presence of a compound of formula (V), MmHnPqOr??(V) wherein M is Group I or II metal; m is 1, 2, 3; n is 0, 1, 2, or 4; q is 1 or 2; r is 4, 7 or 8; in the presence of a C1-4 alcohol and a polar tertiary amide solvent selected from N,N-dimethylacetamide, N,N-dimethylformamide, N,N-dimetheylpropionamide, N,N-diethylacetamide, N,N-diethylformamide and N,N-diethylpropionamide at a temperature ranging from about ?30 to +30° C. and subjecting the product thus obtained to a desired step of purification.Type: GrantFiled: July 25, 2001Date of Patent: June 20, 2006Assignee: Lupin LimitedInventors: Vinod Kumar Kansal, Sunil Gurudatt Bhat, Tanguturi Venkata Marutikumar, Yuvaraj Atmaram Chavan, Ramanathan Sankaran
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Patent number: 6919449Abstract: The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one pot using a halogenating agent in the absence or presence of a solvent, to produce compound of formula (I), activating the 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) using conventional activation agents gives compound of formula (IV), condensing the activated compound of the formula (IV) with 7-amino cephem derivative of the formula (V) to produce a compound of formula (VI), and cyclizing the compound of formula (VI) with thiourea to give cephalosporin compounds of the formula (II).Type: GrantFiled: September 18, 2002Date of Patent: July 19, 2005Assignee: Orchid Chemicals and Pharmaceuticals LimitedInventors: Pandurang Balwant Deshpande, Parven Kumar Luthra, Pratik Ramesh Sathe, Sivakumaran Sundaravadivelan, Praveen Nagesh Ganesh
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Patent number: 6916801Abstract: The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ?-lactamase enzymes, for enhancing the activity of ?-lactam antibiotics, and for treating ?-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula (I), wherein R1 and R2 are each independently hydrogen, (C1-C10)alkyl, (C2-C10)alkenyl, (C2-C10)alkenyl, (C3-C8)cycloalkyl, (C1-C10)alkoxy, (C1-C10)alkanoyl, (C1-C10)alkanoyloxy, (C1-C10)alkoxycarbonyl, aryl, heterocycle, halo, cyano, nitro, —COORe, —C(?O)NRfRg, —OC(?O)NRfRg, NRfRg, or —S(O)nRh; R3 is hydrogen, halo, aryl, heteroaryl, —S(O)nRh, or —CH?CHC(?O)NRmRp; R4 is hydrogen; A is thio, sulfinyl, or sulfonyl; and intermediates useful for the synthesis of compounds of formula (I).Type: GrantFiled: July 24, 2002Date of Patent: July 12, 2005Assignee: Alamx, LLCInventors: John D. Buynak, Lakshminarayana Vogeti
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Patent number: 6906187Abstract: There is described a process for the preparation of 3-disubstituted cepham-4-carboxylic acid derivatives of formula I wherein R? is 4-methoxybenzyl, X is the residue of a thioether and Z is a residue of a nucleophilic compound, such as 2-furoylthio, acetoxy or 1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-ylthio, by reaction of a functional derivative of ?-(2-chloroacetamido)thiazol-4-yl-?-methoxyiminoacetic acid with 7?-amino-3-methylenecepham-4-carboxylic acid 4-methoxybenzyl ester, subsequent treatment of the obtained 4-methoxybenzyl 7?-[?-(2-chloroacetamido)thiazol-4-yl-?-methoxyimino]acetamido-3-methylenecepham-4-carboxylate with a S-chloromercaptan of formula X—S—Cl, such as methanesulfenyl chloride, and final treatment of the corresponding 4-methoxybenzyl 7?-[?-(2-chloroacetamido)thiazol-4-yl-?-methoxyimino]acetamido-3-thio-3-chloromethylcepham-4-carboxylate thus obtained of formula V wherein R? and X are as defined above, with a compound of formula M-Z, in which M is an alkaline metalType: GrantFiled: February 27, 2003Date of Patent: June 14, 2005Assignee: Miat S.p.A.Inventor: Giordano Lesma
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Patent number: 6897304Abstract: A cephem compound or pharmaceutically acceptable salt thereof represented by the formula I: wherein R1 and R2 may be the same or different and each represent hydrogen atom, nitro or cyano; R3 represents C1-C6 alkyl which may be substituted with carboxyl; R4 represents hydrogen atom or amino; X represents —S— or —SO—, there being no case where both of R1 and R2 are simultaneously hydrogen atom.Type: GrantFiled: September 21, 2001Date of Patent: May 24, 2005Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Seiichiro Kawashima, Keiichi Hiramatsu, Hideaki Hanaki, Hiroaki Yamazaki, Hidenori Harada
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Patent number: 6894162Abstract: Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.Type: GrantFiled: September 10, 2001Date of Patent: May 17, 2005Assignee: Sandoz GmbHInventor: Peter Kremminger
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Publication number: 20040267008Abstract: This invention relates a process for preparing a compound of formula (I) 1Type: ApplicationFiled: February 17, 2004Publication date: December 30, 2004Applicant: Pfizer IncInventors: Juan C. Colberg, John L. Tucker, Maurizio Zenoni, Giovanni Fogliato, Alessandro Donadelli, Isao Nagakura, Hiromasa Morita, Hideyuki Matsuo
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Patent number: 6835829Abstract: Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography.Type: GrantFiled: January 21, 2003Date of Patent: December 28, 2004Assignee: Sandoz GmbHInventors: Johannes Ludescher, Werner Veit
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Publication number: 20040260084Abstract: The compounds of the general formula (I) wherein R1 denotes a pharmaceutically acceptable side chain radical as used conventionally in the field of cephalosporins and wherein R2 denotes a pharmaceutically acceptable group which is bonded to the remaining part of the molecule by an oxygen-carbon single bond or a nitrogen-carbon single bond, and their pharmaceutically acceptable salts, esters and amide derivatives are effective antibiotics.Type: ApplicationFiled: March 26, 2004Publication date: December 23, 2004Inventors: Hans R. Pfaendler, Wolfgang Jenni
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Patent number: 6833452Abstract: A process for the preparation of highly pure crystalline form of cefuroxime-1-acetoxyethyl ester (cefuroxime axetil) from cefuroxime by reacting an amine salt of cefuroxime with an esterifying reagent.Type: GrantFiled: July 16, 2001Date of Patent: December 21, 2004Assignee: Ranbaxy Laboratories LimitedInventors: Om Dutt Tyagi, Gyan Chand Yadav, Vijay Kumar Handa
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Publication number: 20040248875Abstract: The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R3 and R5 are independently amino or protected amino; and R4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.Type: ApplicationFiled: June 17, 2004Publication date: December 9, 2004Inventors: Hidenori Ohki, Shinya Okuda, Toshio Yamanaka, Takashi Ogino, Hitomi Ogino, Tetsuya Ogino, Tomomi Takezawa, Kohji Kawabata, Satoshi Inoue, Keiji Misumi, Kenji Itoh, Hisashi Akamatsu, Kenji Satoh
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Publication number: 20040242557Abstract: The present invention relates to a novel process for the preparation of intermediate, 2-mercapto-benzothiazolyl (Z)-2-(2-amino-4-thiazolyl)-2-acetyloxyiminoacetate of Formula I and its use in the preparation of Cefdinir.Type: ApplicationFiled: October 1, 2003Publication date: December 2, 2004Inventors: Ramesh Dandala, V.V. Prasada Rao Korrapati, Meenakhshisunderam Sivakumaran
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Publication number: 20040241173Abstract: A fullerene-antibiotic conjugate including at least one antibiotic molecule per fullerene moiety. The fullerene may comprise C60 and the antibiotic may comprise vancomycin or may be selected from the group consisting of penicillins, cephalosporins, quinolones, fluoroquinolones, macrolides, lincosamines, carbepenems, conobactams, aminoglycosides, glycopeptides, tetracyclines, sulfonamides, rifampin, oxazolidonones, and streptogramins. The conjugate preferably includes at least two and more preferably at least three antibiotic molecules per C60 center. A method for making a fullerene(C60)-antibiotic conjugate, comprises: synthesizing a linker precursor (I); reacting the linker precursor (I) with C60 via a Bingel-reaction, to produce a fullerene-linker conjugate (II); hydrolyzing the fullerene-linker conjugate (II), resulting in a desired derivative of C60 (III); and reacting the derivative (III) with a desired antibiotic to produce a fullerene-antibiotic conjugate (IV).Type: ApplicationFiled: February 11, 2004Publication date: December 2, 2004Applicant: William Marsh Rice UniversityInventors: Lon J. Wilson, Andrey L. Mirakyan, Matthew P. Cubbage