Formation Of Solvate Or Anhydrous Forms, Or Special Crystalline Forms Patents (Class 540/320)
  • Patent number: 11235303
    Abstract: Disclosed is an electrostatic spray drying process for encapsulating a core material, such as a volatile flavor oil, within a carrier or wall material. The process is achieved by atomizing a liquid emulsion comprising the core material and the wall material, applying an electrostatic charge at the site of atomization, and drying the atomized emulsion into an encapsulated, free-flowing powder. Applying an electrostatic charge at the site of atomization allows the spray drying to be accomplished at significantly reduced temperatures, in particular, inlet temperatures in the range of 25° C. to 110° C., and outlet temperatures in the range of 25° C. to 80° C. The low drying temperatures impart improvements in the resulting encapsulated powdered product, including better retention of volatile flavor components, a flavor profile comparable to that of the starting liquid formulation, and better hydration and dissolution in water-based applications.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: February 1, 2022
    Assignee: FONA TECHNOLOGIES, LLC
    Inventors: Robert M. Sobel, Benjamin Bunchean, Chin-Ping Su, Michael Gundlach, Thomas E. Ackerman, Jr., Glenn R. St. Peter
  • Patent number: 10975029
    Abstract: The invention relates to crystalline eravacycline bis-hydrochloride and to a process for its preparation. Furthermore, the invention relates to the use of crystalline eravacycline bis-hydrochloride for the preparation of pharmaceutical compositions. The invention further relates to pharmaceutical compositions comprising an effective amount of crystalline eravacycline bis-hydrochloride. The pharmaceutical compositions of the present invention can be used as medicaments, in particular for treatment and/or prevention of bacterial infections e.g. caused by Gram negative pathogens or Gram positive pathogens, in particular caused by multidrug resistant Gram negative pathogens. The pharmaceutical compositions of the present invention can thus be used as medicaments for e.g. the treatment of complicated intra-abdominal and urinary tract infection.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: April 13, 2021
    Assignee: Sandoz AG
    Inventor: Hannes Lengauer
  • Patent number: 10934317
    Abstract: Crystalline forms of brigatinib, pharmaceutical compositions comprising the same, and methods of their preparation and use of the same are disclosed herein.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: March 2, 2021
    Assignee: ARIAD Pharmaceuticals, Inc.
    Inventors: Leonard W. Rozamus, Pradeep Sharma
  • Patent number: 10385078
    Abstract: Crystalline forms of brigatinib, pharmaceutical compositions comprising the same, and methods of their preparation and use of the same are disclosed herein.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: August 20, 2019
    Assignee: ARIAD PHARMACEUTICALS, INC.
    Inventors: Leonard W. Rozamus, Pradeep Sharma
  • Patent number: 7022841
    Abstract: The present invention relates to a process for reducing the levels of organic solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula I: or a salt thereof, wherein R1 and R2, are the same or different, and are selected from H, alkyl, aryl, and heteroaryl, comprising washing a carbapenem solid containing organic solvent with an organic solvent containing water; and using vacuum and/or inert gas (hydrated or dry) at low temperature to produce a compound of formula I containing pharmaceutically acceptable levels of organic solvents, wherein the water content of the crystalline carbapenem solid, correcting for organic solvents, is maintained at about 13% to about 25% during the process.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: April 4, 2006
    Assignee: Merck & Co. Inc.
    Inventors: Raymond Cvetovich, Robert Wenslow, John M. Williams, Daniel Sidler, Louis Crocker, Hsien-Hsin Tung, Brian K. Johnson, Joseph Kukura, II, Ulf Dolling
  • Patent number: 6242581
    Abstract: Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2+ and a coordination number of 6. A method for synthesizing the metal ion-CM-Asp complex is also described. Further, the metal ion-CM-Asp complex can be used for screening protein function.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: June 5, 2001
    Assignee: Clontech Laboratories, Inc.
    Inventors: Paul S. Nelson, Te-Tuan Yang, Steven R. Kain, Thomas H. Smith
  • Patent number: 5532232
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: July 2, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus Muller, Ludvik Labler, Gerard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Patent number: 4882325
    Abstract: Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(D-.alpha.-amino-.alpha.-phenylacetamido)penicillanate napsylate. The product may be prepared by reacting 1,1-dioxopenicillanoyloxymethyl 6-(D-.alpha.-amino-.alpha.-phenylacetamido)penicillanate or a salt thereof with 2-naphthalenesulfonic acid or salt thereof.
    Type: Grant
    Filed: October 21, 1988
    Date of Patent: November 21, 1989
    Assignee: Leo Pharmaceutical Products Ltd. A/S
    Inventors: Wagn O. Godtfredsen, Welf von Daehne
  • Patent number: 4866170
    Abstract: A stable trihydrate of (2S, 5R, 6R)-6-{(2R)-2-[(2R)-2-amino-3-(N-methylcarbamoyl)propionamido]-2-(p-hydrox yphenyl)acetamido}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-c arboxylic acid and process for preparing the same are disclosed.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: September 12, 1989
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Susumu Ohshiro, Masaru Senuma, Mitsuyoshi Wagatsuma
  • Patent number: 4863915
    Abstract: Crystalline anhydrous amoxycillin is prepared by removing bound solvent molecules from a crystalline solvate (other than the trihydrate) of amoxycillin. A preferred crystalline solvate is the monomethanolate.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 5, 1989
    Assignee: Beecham Group p.l.c.
    Inventor: Neil Ward