Patent number: 6525041
Abstract: Low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:
wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, and R′9, M, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
Type:
Grant
Filed:
March 14, 1996
Date of Patent:
February 25, 2003
Assignee:
Pharmacia Corporation
Inventors:
William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J. Lennon, Karl W. Aston