Two Of The Cyclos Share At Least Three Ring Members Or A Ring Carbon Is Shared By Three Of The Cyclos (e.g., Bridged, Peri-fused, Etc.) Patents (Class 540/62)
  • Sterol derivatives and their synthesis and use
    Patent number: 8853194
    Abstract: Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: October 7, 2014
    Inventors: Dagang Chen, Haimin Lei
  • CONTRACEPTIVE AGENTS
    Publication number: 20140005132
    Abstract: The invention provides compounds of formula I, II, III, or IV: wherein R1 to R11, X, and Y have any of the values defined in the specification. The compounds inhibit Na, K-ATPase ?4 and are useful as contraceptive agents.
    Type: Application
    Filed: July 1, 2013
    Publication date: January 2, 2014
    Applicants: REGENTS OF THE UNIVERSITY OF MINNESOTA, THE UNIVERSITY OF KANSAS
    Inventors: Gustavo Blanco, Gunda I. Georg, Shameem Sultana Syeda
  • Sterol Derivatives and Their Synthesis and Use
    Publication number: 20120130067
    Abstract: Sterol derivatives with structural formula I or II are disclosed, wherein R is defined as the description of the invention. Their synthesizing methods and anti-tumor use are also disclosed. Especially, the compound of formula I, in which R is O (i.e. the compound CL 168-6), has the anti-tumor therapeutic index of 49.3. The compound can be used to prepare a medicine for prevention or treatment of immunological diseases and cancers such as liver cancer and lung cancer.
    Type: Application
    Filed: January 15, 2010
    Publication date: May 24, 2012
    Inventors: Dagang Chen, Haimin Lei
  • 14-.alpha.,17-.alpha.-C.sub.2 -bridged norprogesterone derivatives
    Patent number: 5973172
    Abstract: The invention describes 14,17-C.sub.2 -bridged steroids of general formula (I), ##STR1## wherein the various R groups are as defined in the specification, and wherein said steroids are in contrast, with the disclaimed compound, the new compounds are available even after peroral administration with high gestagenic action and are suitable for the production of pharmaceutical agents.
    Type: Grant
    Filed: August 18, 1998
    Date of Patent: October 26, 1999
    Assignee: Schering Akitengesellschaft
    Inventors: Klaus Schollkopf, Wolfgang Halfbrodt, Joachim Kuhnke, Wolfgang Schwede, Karl-Heinrich Fritzemeier, Rolf Krattenmacher, Hans-Peter Muhn
  • UCY1003 derivatives
    Patent number: 4952576
    Abstract: Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: August 28, 1990
    Assignee: Kyowa Hakko Kogyo Kabushiki Kaisha
    Inventors: Toru Yasuzawa, Hiroshi Sano, Hirofumi Nakano, Shunji Ichikawa, Katsuichi Shuto
  • Novel substance UCY1003 and process for preparing the same
    Patent number: 4914198
    Abstract: Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: April 3, 1990
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Hirofumi Nakano, Mitsunobu Hara, Yoshinori Yamashita, Isao Kawamoto, Katsuhiko Ando, Hiroshi Sano, Toru Yasuzawa, Katsuichi Shuto
  • Topically active steroidal anti-inflammatory agents
    Patent number: 4910192
    Abstract: Introduction of a C-12 substituent and especially a .beta. C-12 substituent into glucocorticoids improves their usefulness as topical antiinflammatories by increasing their topical activity relative to their systemic activity, thus reducing systemic side effects such as adrenal suppression.
    Type: Grant
    Filed: December 4, 1987
    Date of Patent: March 20, 1990
    Assignee: SRI International
    Inventors: Mitchell A. Avery, Masato Tanabe, Dennis Yasuda, George Detre