Abstract: Cationic surface-active agents which are polyhydroxylated tertiary amines or the quaternary ammonium salts thereof and which are usefully employed in cosmetic compositions, are prepared by condensing on a fatty alcohol, glycerol epihalohydrin alone or together with an epoxide to form polyhalogenated polyethers, which in turn are converted to polyhalogenated glycidyl ethers, the latter being reacted with a secondary amine to form polyhalogenated tertiary amines which are then reacted with sodium or potassium acetate in the presence of a diol to form said polyhydroxylated tertiary amines.
Abstract: Novel 7-amino-benzocycloheptenes of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, bromine and iodine in the 2- or 4-position when a halogen, Y and Z are hydrogen or together form a double bond, R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl optionally substituted with fluorine, chlorine, methyl or methoxy, R.sub.1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.2 is selected from the group consisting of alkyl of 1 to 5 carbon atoms and alkenyl of 2 to 5 carbon atoms and R.sub.1 and R.sub.
Type:
Grant
Filed:
July 26, 1976
Date of Patent:
May 23, 1978
Assignee:
Roussel Uclaf
Inventors:
Lucien Nedelec, Andre Pierdet, Claude Dumont, Marie-Helene Kannengiesser
Abstract: Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein X is an alkylene group of 2 - 4 carbon atoms; Y is CH.sub.2 or 0; R.sub.1 is a hydrogen atom or a C.sub.1-6 alkyl group; R.sub.2 is a hydrogen atom or a C.sub.1-6 alkyl or benzyl group or is joined to R.sub.1 so that NR.sub.1 R.sub.1 is a 5-, 6- or 7- membered saturated ring; R.sub.3 is a naphthyl group or a naphthyl group substituted by a fluorine, chlorine or bromine atom or a methyl, methoxyl, trifluoromethyl, hydroxy or acetoxy group; R.sub.4 is a hydrogen atom or a C.sub.1-4 alkyl group; and R.sub.5 is a hydrogen atom or a C.sub.1-4 alkyl group; have been found to be mood modifying agents.
Abstract: Derivatives of 2-aroyl-3-phenylindenes, 3-aroyl-4-phenyl-1,2-dihydronaphthalenes, and 1-phenyl-2-aroyl-naphthalenes are useful as antifertility agents.
Abstract: Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.
Abstract: A new process for the manufacture of N-substituted tetrahydro-1,4-oxazines, also called morpholines, by conversion of N-substituted bis-(2-hydroxyalkyl)-amines in the presence of catalysts.
Type:
Grant
Filed:
July 22, 1976
Date of Patent:
January 10, 1978
Assignee:
BASF Aktiengesellschaft
Inventors:
Norbert Goetz, Bernd Zeeh, Martin Decker, Leopold Hupfer, Herbert Toussaint
Abstract: Biphenylyl ethers of the formula R--O--CH.sub.2 --CR.sub.1 (OH)--CH.sub.2 Z wherein R.sub.1 is H or CH.sub.3 ; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I, CF.sub.3, NO.sub.2 and piperidino or, when R.sub.1 is CH.sub.3 or when Z is homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino, unsubstituted biphenyl, and the physiologically acceptable acid addition salts thereof, possess cholesterol blood-level-lowering activity and can be produced by reacting a compound of the formula R--O--CH.sub.2 --Y wherein Y is ##STR1## or --CR.sub.1 (OH)--CH.sub.2 X, X being Cl, Br, I or a free or functionally modified OH-group, with an amine of the formula H-Z.
Type:
Grant
Filed:
October 29, 1974
Date of Patent:
November 29, 1977
Assignee:
Merch Patent Gesellschaft mit beschrankter Haftung
Inventors:
Erich Schacht, Werner Mehrhof, Rochus Jonas, Herbert Nowak, Zdenek Simane
Abstract: Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a hyterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
Type:
Grant
Filed:
May 19, 1976
Date of Patent:
November 29, 1977
Assignee:
Ayerst McKenna and Harrison Ltd.
Inventors:
Jean-Marie Ferland, Real Laliberte, Wilbur Lippmann, Thomas A. Pugsley
Abstract: Morpholine derivatives, typically those of the formula: ##STR1## wherein A is an ethylene or vinylene radical and X is a phenyl radical optionally substituted by one or two substituents selected from halogen atoms, alkyl and alkoxy radicals of 1 to 6 carbon atoms and aryloxy radicals of 1 to 6 carbon atoms, the aryloxy radicals themselves being optionally substituted by one or two substituents selected from halogen atoms and alkyl radicals of 1 to 4 carbon atoms, and the pharmaceutically-acceptable acid-addition salts thereof. Processes for making these compounds, pharmaceutical compositions containing them and a method of restoring to normal abnormal mental states in warm-blooded animals are also disclosed.
Type:
Grant
Filed:
October 22, 1976
Date of Patent:
September 20, 1977
Assignee:
Imperial Chemical Industries Limited
Inventors:
Bernard Joseph McLoughlin, Allen John Guildford
Abstract: 2-Morpholinol derivatives characterized by having an aryloxymethyl radical attached to the 6 position and an alkyl or alkynyl radical attached to the nitrogen at the 4 position are disclosed. The derivatives may be optionally substituted at the 2 position with an alkyl or aryl group and the hydroxyl function at position 2 may be replaced with an alkoxy group. The 2-morpholinol derivatives of this invention are useful .beta.-adrenergic blocking and antifungal agents. Methods for the preparation and use of these derivatives are also described.
Abstract: The invention relates to substituted 5-(phenyl)benzoic acid esters and non-toxic pharmaceutically accepted salts thereof and processes for their preparation. The substituted 5-(phenyl)benozic acids are useful as anti-inflammatory compounds. Also included are method of treating inflammation claims by administering these particular compounds to patients.
Type:
Grant
Filed:
October 8, 1971
Date of Patent:
August 23, 1977
Assignee:
Merck & Co., Inc.
Inventors:
William V. Ruyle, Lewis H. Sarett, Alexander R. Matzuk
Abstract: This disclosure describes homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid, having antimicrobial activity and prostaglandin-like hypotensive activity.
Type:
Grant
Filed:
May 5, 1975
Date of Patent:
August 23, 1977
Assignee:
American Cyanamid Company
Inventors:
Karel Francis Bernady, Middleton Brawner Floyd, Jr., John Frank Poletto, Robert Eugene Schaub, Martin Joseph Weiss
Abstract: This application discloses arylethynylphenylcyclopropylamines and processes for their preparation. These amines exhibit monoamine oxidase (MAO) inhibiting activity.