N-hydrocarbyl Morpholines Patents (Class 544/178)
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Publication number: 20100279340Abstract: Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.Type: ApplicationFiled: February 11, 2008Publication date: November 4, 2010Applicant: NYUInventors: Thomas Wisniewski, Jaeki Min, Qian Li, Young-Tae CHANG
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Publication number: 20100274010Abstract: Processes for preparing an amine, which processes comprise: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, and 0.2 to 40% by weight of an oxygen compound of cobalt, calculated as CoO, 0.1 to 5% by weight of an oxygen compound of iron, calculated as Fe2O3, and 0.1 to 5% by weight of at least one oxygen compound of lead, tin, bismuth or antimony, calculated as PbO, SnO, Bi2O3 and Sb2O3 respectively.Type: ApplicationFiled: December 10, 2008Publication date: October 28, 2010Applicant: BASF SEInventors: Petr Kubanek, Wolfgang Mägerlein, Ekkehard Schwab, Johann-Peter Melder, Manfred Julius
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Publication number: 20100274011Abstract: Processes for preparing an amine, the processes comprising: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, and nickel, 1.5 to 4.5% by weight of an oxygen compound of cobalt, calculated as CoO, and 0.2 to 5.0% by weight of at least one oxygen compound of niobium, sulfur, phosphorus, gallium, boron, lead or antimony, calculated in each case as Nb2O5, H2SO4, H3PO4, Ga2O3, B2O3, PbO and Sb2O3 respectively, and wherein the catalytically active composition does not comprise any molybdenum.Type: ApplicationFiled: December 10, 2008Publication date: October 28, 2010Applicant: BASF SEInventors: Petr Kubanek, Wolfgang Mägerlein, Ekkehard Schwab, Johann-Peter Melder, Manfred Julius
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Patent number: 7714089Abstract: Rubbery polymers can be formed having the general formula: R1R2N—(CH2)n—X—CH2—CHR3R4 wherein R1 and R2 are independently selected from a group consisting of alkyls, cycloalkyls, alkenyls, cycloalkenyls, aryls, phenyls, heterocycles, acyls, and silanes, or R1 in combination with R2 forms a heterocyclic ring; n is an integer from 1 to 20; X is selected from a group consisting of sulfur, a phosphorus moiety, and a silicon moiety; R3 and R4 are one of hydrogen, alkyls, alkenyls, and at least one of which includes reactive unsaturation such as an alkenyl group. Moreover, this invention discloses a process of making functionalized rubbery polymers from the functionalized monomers.Type: GrantFiled: December 13, 2007Date of Patent: May 11, 2010Assignee: The Goodyear Tire & Rubber CompanyInventors: Adel Farhan Halasa, Wen-Liang Hsu, Leh-Yeh Hsu, legal representative, Shingo Futamura, Joe Zhou, Chad Aaron Jasiunas
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Publication number: 20100004442Abstract: Amorolfine base, which is a compound of formula (I): is improvedly prepared by: (i) contacting a compound of formula (II): with a Friedel-Crafts catalyst; and (ii) adding one equivalent of 2-halogeno-2-methylbutane, wherein the reaction mixture obtained in step (i) is cooled to a temperature from ?40° to ?60° C. prior to step (ii) and the Friedel-Craft catalyst is selected from the group consisting of gallium chloride, antimony pentafluoride, molybdenum pentachloride, indium chloride, antimony pentachloride.Type: ApplicationFiled: June 22, 2009Publication date: January 7, 2010Applicant: GALDERMA S.A.Inventors: Beat Weber, Stefan Rosenberger
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Publication number: 20090286977Abstract: Processes comprising: (i) providing a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones and mixtures thereof; and (ii) reacting the reactant with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a catalyst comprising a zirconium dioxide- and nickel-containing catalytically active composition, to form an amine; wherein the catalytically active composition, prior to reduction with hydrogen, comprises oxygen compounds of zirconium, copper, nickel and cobalt, and one or more oxygen compounds of one or more metals selected from the group consisting of Pb, Bi, Sn, Sb and In.Type: ApplicationFiled: July 4, 2007Publication date: November 19, 2009Applicant: BASF SEInventors: Petr Kubanek, Bram Willem Hoffer, Ekkehard Schwab, Johann-Peter Melder, Holger Evers, Till Gerlach
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Publication number: 20090163711Abstract: An improved process of producing Amorolfine base, which is a compound of formula (I): said process including the steps of: (i) contacting a compound of formula (II): with a Friedel-Crafts catalyst at a temperature in the range of 20° to 30° C.; (ii) adding a 2-halogeno-2-methylbutane thereto, and wherein the reaction mixture obtained in step (i) is cooled to a temperature of from ?40° to ?60° C. prior to step (ii).Type: ApplicationFiled: July 27, 2006Publication date: June 25, 2009Applicant: GALDERMA S.A.Inventors: Beat Weber, Stefan Rosenberger
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Publication number: 20090131660Abstract: 3-[4-(1,1-Dimethyl-propyl)-phenyl]-2-methyl-propionaldehyde and cis-4-{3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propyl}-2,6-dimethyl-morpholine (Amorolfine) are synthesized, first by Heck reacting a compound of general formula (VI): with 2-methyl-prop-2-en-1-ol of formula (VII): in the presence of a palladium catalyst and a base, in a solvent selected from among N,N-dimethylformamide, polar protic and non-polar organic solvents, and at a temperature ranging from 60° C. to 150° C., and then conducting an amino reduction by reacting the 3-[4-(1,1-dimethyl-propyl)-phenyl]-2-methyl-propionaldehyde of formula (II) with cis-2,6-dimethyl morpholine of formula (IV): in the presence of a reducing agent and in a solvent.Type: ApplicationFiled: October 3, 2008Publication date: May 21, 2009Applicant: GALDERMA S.A.Inventors: JEAN-GUY BOITEAU, BRANISLAV MUSICKI
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Publication number: 20090082562Abstract: A process for preparing an amine by reacting an aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group of primary and secondary amines in the presence of a heterogeneous catalyst, wherein the catalyst is a coated catalyst which comprises at least one metal of group VIII of the Periodic Table of the Elements as a hydrogenating metal and additionally a promoter on an oxidic support, at least 80% of the metal of group VIII of the Periodic Table of the Elements being present in a layer between the surface of the catalyst and a penetration depth which is not more than 80% of the radius of the catalyst, calculated from the surface of the catalyst.Type: ApplicationFiled: March 13, 2007Publication date: March 26, 2009Applicant: BASF SEInventors: Jan Eberhardt, Bram Willem Hoffer, Frank Haese, Johann-Peter Melder, Bernd Stein, Michael Stang, Thomas Hill, Ekkehard Schwab
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Publication number: 20090030200Abstract: Disclosed is a process of preparing an optically active allyl compound comprising asymmetrically coupling an allyl compound with an organic nucleophilic compound in the presence of a catalyst. The catalyst is preferably a transition metal complex compound having a phosphine ligand. The phosphine ligand is preferably a 2,3-bis(dialkylphosphino)pyrazine derivative. The pyrazine derivative is preferably a quinoxaline derivative. The transition metal is preferably palladium.Type: ApplicationFiled: July 24, 2008Publication date: January 29, 2009Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, NIPPON CHEMICAL INDUSTRIAL CO., LTD.Inventors: Tsuneo IMAMOTO, Kazuhiro YOSHIDA, Miwako NISHIMURA, Aya KOIDE
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Patent number: 7220884Abstract: The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.Type: GrantFiled: January 21, 2005Date of Patent: May 22, 2007Assignee: Dow Global Technologies, Inc.Inventors: John R. Briggs, Gregory T. Whiteker, Jerzy Klosin
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Patent number: 7179912Abstract: Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.Type: GrantFiled: August 28, 2001Date of Patent: February 20, 2007Assignee: ICOS CorporationInventors: James Halbrook, Edward A. Kesicki, Laurence E. Burgess, Stephen T. Schlachter, Charles T. Eary, Justin G. Schiro, Hongmei Huang, Michael Evans, Yongxin Han
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Patent number: 7105662Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I in which R1 and R2, independently of one another, are hydrogen, alkyl or cycloalkyl, or R1 and R2 together with the carbon atom to which they are bonded are a 5- to 14-membered carbocycle, and R3 and R4, independently of one another, are alkyl or cycloalkyl, by reacting at least one carbonyl compound of the formula II in which R1 and R2 have the meanings given above, with at least one morpholine of the formula III in which R3 and R4 have the meanings given above, in the presence of hydrogen and at least one metal-containing catalyst, wherein the active component of the catalyst consists essentially of platinum group metals.Type: GrantFiled: March 15, 2002Date of Patent: September 12, 2006Assignee: BASF AkteingesellschaftInventors: Michael Henningsen, Andreas Kusche, Michael Hüllmann, Lothar Rüb, Stefan Käshammer, Till Gerlach
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Patent number: 7022845Abstract: A process for the monomethylation of nitrogenous heterocycles having at least one nitrogen atom bonded to a hydrogen atom by reacting the nitrogenous heterocycle with dimethyl carbonate at a temperature of between 100° and 200° C. and a pressure of between 0.93×105 Pa and 1.07×105 Pa while methanol produced during the reaction is distilled off as it is formed.Type: GrantFiled: July 31, 2003Date of Patent: April 4, 2006Assignee: Group SNPEInventors: Elisabeth Borredon, Berhard Chabaud, Antoine Gaset, Sophie Thiebaud-Roux, Samedy Ouk
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Patent number: 6894191Abstract: The present invention provides a process for the preparation of arylamines comprises reacting aryl halide and aryl amine/heterocyclic amine. The said process is carried out in the presence of a solvent, catalyst and a base.Type: GrantFiled: December 10, 2003Date of Patent: May 17, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Ashutosh Anant Kelkar, Nandkumar Manikrao Patil, Raghunath Vitthal Chaudhari
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Publication number: 20040267011Abstract: The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.Type: ApplicationFiled: April 12, 2004Publication date: December 30, 2004Applicant: Dana-Farber Cancer InstituteInventors: Andre Rosowsky, Han Chen
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Publication number: 20040122181Abstract: The present invention relates to vulcanization accelerators constituted by compounds, derived from secondary amines, belonging to the class of enamines and to a process for their preparation.Type: ApplicationFiled: December 9, 2003Publication date: June 24, 2004Applicant: Great Lakes Chemical Italia S.r.L.Inventors: Fabio Broussard, Mauro Adovasio, Corrado Collierotti, Gianbattista Taroni, Jose Roncalli
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Publication number: 20040122224Abstract: This invention discloses a process for synthesizing an amine functionalized monomer that comprises (1) reacting a secondary amine with a 2,3-dihalopropene to produce a vinyl halide containing secondary amine having a structural formula selected from the group consisting of 1Type: ApplicationFiled: December 9, 2003Publication date: June 24, 2004Applicant: The Goodyear Tire & Rubber CompanyInventors: Adel Farhan Halasa, Wein-Liang Hsu, Jin-Ping Zhou, Chad Aaron Jasiunas, Corey Stanton Yon
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Publication number: 20040077857Abstract: The present invention relates to a process for the preparation of N-substituted 2,6-dialkylmorpholines of the formula I 1Type: ApplicationFiled: September 11, 2003Publication date: April 22, 2004Inventors: Michael Henningsen, Andreas Kusche, Michael Hullmann, Lothar Rub, Stefan Kashammer, Till Gerlach
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Publication number: 20040024205Abstract: A process for the monomethylation of nitrogenous heterocycles having at least one nitrogen atom bonded to a hydrogen atom by reacting the nitrogenous heterocycle with dimethyl carbonate at a temperature of between 100° and 200° C. and a pressure of between 0.93×105 Pa and 1.07×105 Pa while methanol produced during the reaction is distilled off as it is formed.Type: ApplicationFiled: July 31, 2003Publication date: February 5, 2004Inventors: Elisabeth Borredon, Berhard Chabaud, Antoine Gaset, Sophie Thiebaud-Roux, Samedy Ouk
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Patent number: 6683181Abstract: The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.Type: GrantFiled: November 5, 2002Date of Patent: January 27, 2004Assignee: Pharmacia and Upjohn ComapnyInventors: Valerie A. Vaillancourt, Sandra Staley, Audris Huang, Richard Allen Nugent, Ke Chen, Sajiv K. Nair, James A. Nieman, Joseph Walter Strohbach
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Patent number: 6613773Abstract: The invention provides fungicidal compounds of formula (I) or stereoisomers thereof: wherein X is CH2O; A is hydrogen; E is hydrogen; q is 1; any two of K, L and M are nitrogen and the other is CH; T is oxygen or sulfur; and Z is an optionally substituted phenyl group or an optionally substituted heterocyclyl group.Type: GrantFiled: March 5, 2002Date of Patent: September 2, 2003Assignee: Syngenta LimitedInventors: John Martin Clough, Christopher Richard Ayles Godfrey, Ian Thomas Streeting, Rex Cheetham, Paul John de Fraine, David Bartholomew, James John Eshelby
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Patent number: 6562989Abstract: The present invention is directed to a transition metal catalyst, comprising a Group 8 metal and a ligand having the structure wherein R, R′ and R″ are organic groups having 1-15 carbon atoms, n=1-5, and m=0-4. The present invention is also directed to a method of forming a compound having an aromatic or vinylic carbon-oxygen, carbon-nitrogen, or carbon-carbon bond using the above catalyst. The catalyst and the method of using the catalyst are advantageous in preparation of compounds under mild conditions of approximately room temperature and pressure.Type: GrantFiled: August 3, 2001Date of Patent: May 13, 2003Assignee: Yale UniversityInventors: John F. Hartwig, Quinetta Shelby, Noriyasu Kataoka
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Publication number: 20030009029Abstract: The present invention relates to a process preparing compounds of the general formula (I) 1Type: ApplicationFiled: June 5, 2002Publication date: January 9, 2003Applicant: Merck Patent GmbHInventors: Herwig Buchholz, Urs Welz-Biermann
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Patent number: 6503905Abstract: The present invention relates to compounds of the formula I, wherein Z1, Z2, X, Q, R1, R2 and R3 are defined as in the specification, pharmaceutical compositions containing such compounds the use of such compounds to treat neurological and gastrointestinal disorders.Type: GrantFiled: August 6, 1999Date of Patent: January 7, 2003Assignee: Pfizer IncInventors: Spiros Liras, Martin P. Allen, Barbara E. Segelstein
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Patent number: 6441244Abstract: The invention relates to new compounds of the formula (I) in which R is phenyl, C1-4alkyl-, C1-4alkoxy- or halogen-substituted phenyl, naphthyl or an aromatic ring containing heteroatoms; X is O or S; R1 and R2 are each a methyl radical or R1 and R2 together are a C4-8alkylene radical; Y is hydroxyl, C1-12alkoxy, C1-4alkylamino, di-C1-4alkylamino or a piperidine or morpholine ring that is attached by its nitrogen atom; to a process for preparing them and to their use as photoinitiators and/or photosensitizers.Type: GrantFiled: July 12, 2001Date of Patent: August 27, 2002Assignee: Clariant Finance (BVI) LimitedInventors: Lajos Avar, René Bär, Victor Sanahuja
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Publication number: 20010047097Abstract: The invention relates to a process for the preparation of 2-arylethylamine derivates having an alkyl substituent in the 1-position, of the formula (I)Type: ApplicationFiled: May 17, 2001Publication date: November 29, 2001Inventors: Harald Trauthwein, Matthais Beller, Claudia Breindl, Christian Hartung, Annegret Tillack
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Patent number: 6294564Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and Y have the meanings given in the description. Said compounds are novel active bronchial therapeutic agents.Type: GrantFiled: November 1, 2000Date of Patent: September 25, 2001Assignee: Byk Gulden Lomberg Chemische Fabrik GmbHInventor: Thomas Bär
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Patent number: 6255550Abstract: The present invention is directed to organic solutions of the reagent dimethyl titanocene which further comprise a sterically hindered ester and optionally titanocene dichloride. Stability of the reagent dimethyl titanocene is enhanced by the presence of the sterically hindered ester.Type: GrantFiled: October 28, 1999Date of Patent: July 3, 2001Assignee: Merck & Co., Inc.Inventor: Mark Huffman
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Patent number: 5917039Abstract: In a process for the N-alkylation of amines in which alcohols are reacted with alkylamines or dialkylamines in the presence of hydrogen, the reaction takes place on a catalyst based on copper and magnesium silicate and containing, in each case independently, 0 to 2% by weight of BaO, Cr.sub.2 O.sub.3 and/or ZnO. The amines employed are mono- or dimethylamine or mono- or diethylamine, the alcohols employed are .alpha.,.omega.-diols, in particular diethylene glycol or pentanediol. In particular there is reaction of diethylene glycol with monomethylamine and/or monoethylamine to give N-methylmorpholine and/or N-ethylmorpholine.Type: GrantFiled: March 4, 1998Date of Patent: June 29, 1999Assignee: BASF AktiengesellschaftInventors: Joachim Simon, Rainer Becker, Rolf Lebkucher, Horst Neuhauser
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Patent number: 5886175Abstract: The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.Type: GrantFiled: December 8, 1994Date of Patent: March 23, 1999Assignee: American Cyanamid CompanyInventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
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Patent number: 5847131Abstract: N-Substituted cyclic amines are prepared by reacting diols with primary amines over a copper-containing catalyst which is obtainable by impregnation of an inert support with an aqueous solution of an ammine complex of a readily thermally decomposable copper compound and subsequent drying and calcination and contains from 5 to 50% by weight of copper, calculated as CuO.Type: GrantFiled: June 16, 1997Date of Patent: December 8, 1998Assignee: BASF AktiengesellschaftInventors: Joachim Simon, Roman Dostalek, Heinz Lingk, Rainer Becker, Andreas Henne, Rolf Lebkucher, Cristina Freire Erdbrugger, Michael Hesse, Detlef Kratz
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Patent number: 5831128Abstract: The present invention relates to a process for the preparation of aromatic amines of the formula (I)Ar--NR.sup.1 R.sup.2 (I)in which Ar is ##STR1## and R.sup.3 to R.sup.9 independently of one another are hydrogen, C.sub.1 -C.sub.8 -alkyl, alkoxy-(C.sub.1 -C.sub.8), acyloxy-(C.sub.1 -C.sub.8), OAr, Ar, fluorine, chlorine, bromine, iodine, OH, NO.sub.2, CN, CO.sub.2 H, CHO, SO.sub.3 H, SO.sub.2 R, SOR, NH.sub.2, NH-alkyl-(C.sub.1 -C.sub.12), N-alkyl.sub.2 -(C.sub.1 -C.sub.12), NHCO-alkyl-(C.sub.1 -C.sub.12), CO-alkyl-(C.sub.1 -C.sub.12), NHCHO, COAr, CO.sub.2 Ar, CF.sub.3, CONH.sub.2, CHCHCO.sub.2 R, POAr.sub.2, PO-alkyl.sub.2 -(C.sub.1 -C.sub.12), 5-ring heteroaryl, 6-ring heteroaryl, Si-alkyl.sub.3 -(C.sub.1 -C.sub.12), where R=alkyl(C.sub.1 -C.sub.8), aryl(C.sub.5 -C.sub.10) and R.sup.1 and R.sup.2 independently of one another are hydrogen, C.sub.1 -C.sub.Type: GrantFiled: December 3, 1997Date of Patent: November 3, 1998Assignee: Hoechst AktiengesellschaftInventors: Matthias Beller, Thomas Riermeier, Claus Peter Reisinger, Wolfgang Anton Herrmann, Holger Geissler
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Patent number: 5817877Abstract: A process of preparing an organic amine having at least one unsaturated group, such as an arylamine, involving contacting an unsaturated organic sulfonate, such as an aryl sulfonate, with a reactant amine, such as an alkyl or aryl amine, in the presence of a base and a transition metal catalyst under reaction conditions. The transition metal catalyst contains a Group 8 metal and a chelating ligand, for example a Group 15-substituted arylene or Group 15-substituted metallocene, such as 1,1'-bis(diphenylphosphino)-2,2'-binaphthyl or 1,1'-bis(diphenylphosphino)-ferrocene, respectively. The aryl sulfonate can be prepared from a phenol and sulfonating agent.Type: GrantFiled: September 19, 1997Date of Patent: October 6, 1998Assignee: Yale UniversityInventors: John F. Hartwig, Michael S. Driver, Janis Louie, Blake Hamann
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Patent number: 5760224Abstract: Novel morpholines of formula (I) and their salts, wherein R and R1 are each either hydrogen or fluorine and R2 is hydrogen or methyl. The compounds have a variety of uses in human medicine, in particular in the treatment of mental disorders such as depression.Type: GrantFiled: March 28, 1997Date of Patent: June 2, 1998Assignee: Glaxo Wellcome Inc.Inventors: Nariman Bomanshaw Mehta, Grady Evan Boswell, James Leroy Kelley
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Patent number: 5648347Abstract: A method for the treatment of depression in a human being, the method comprising administering to the human being an antidepressant effective amount of a compound of the following formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R and R.sup.1 are independently hydrogen or fluorine.Type: GrantFiled: May 19, 1995Date of Patent: July 15, 1997Assignee: Glaxo Wellcome Inc.Inventors: Nariman Bomanshaw Mehta, Grady Evan Boswell, James Leroy Kelley
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Patent number: 5495032Abstract: The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R.sup.3, R.sup.4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar-protic or a polar-aprotic solvent. The resulting compounds are useful as antibiotics.Type: GrantFiled: September 27, 1994Date of Patent: February 27, 1996Assignee: American Cyanamid CompanyInventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
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Patent number: 5495018Abstract: The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.Type: GrantFiled: December 8, 1994Date of Patent: February 27, 1996Assignee: American Cyanamid CompanyInventors: Phaik-Eng Sum, Ving J. Lee, Joseph J. Hlavka, Raymond T. Testa
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Patent number: 5442059Abstract: The invention provides compounds of the formula: ##STR1## wherein R, and R.sup.1 and W are defined in the specification. These compounds are useful as antibiotic agents.Type: GrantFiled: August 13, 1992Date of Patent: August 15, 1995Assignee: American Cyanamid CompanyInventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
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Patent number: 5386058Abstract: A method for producing polymethine dyes comprising the steps of:(a) reacting a 1,1-diaryl-2-metallo-ethene with an .omega., .omega.,-diaryl-polyalkene-aldehyde in an anhydrous solvent under an inert atmosphere; and(b) neutralizing the reaction mixture from step (a) with an acid, thereby producing a polymethine dye.Type: GrantFiled: October 29, 1993Date of Patent: January 31, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventor: Roger A. Mader
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Patent number: 5352785Abstract: A process for the purification of a perfluorochemical composition comprises continuously mixing the perfluorochemical composition, comprising a liquid mixture of inert perfluorochemicals (e.g., perfluoroalkanes, perfluoroethers, perfluoroaminoethers, or perfluoroalkyl tertiary amines) and isomeric fluorohydrochemicals, with a stabilization composition comprising water-miscible alkanol and an aqueous solution of base (such as potassium hydroxide) made by dissolving the base in an amount of water sufficient to dissolve or disperse the fluoride salt by-products of the subsequent reaction of the base with the fluorohydrochemicals to form fluoroolefins, the amount of the alkanol in the stabilization composition being in stoichiometric excess of the amount needed to completely convert the fluoroolefins to alkoxyvinyl ethers. The process can be utilized to purify the product mixtures resulting from fluorination methods such as direct fluorination or ECF.Type: GrantFiled: March 30, 1993Date of Patent: October 4, 1994Assignee: Minnesota Mining and Manufacturing CompanyInventors: Thomas C. Herzberg, Robert B. Fletcher, Randall F. Henderson
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Patent number: 5328902Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.Type: GrantFiled: August 13, 1992Date of Patent: July 12, 1994Assignee: American Cyanamid Co.Inventors: Phaik-Eng Sum, Ving J. Lee, Raymond T. Testa
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Patent number: 5296633Abstract: The methylated tertiary amines are selectively prepared by reacting a primary or secondary amine, or a nitrile or aminonitrile, including an aminoalcohol, etheramine, a polyamine or fatty polyamine or amidoamine, or amidopolyamine or dinitrile, with hexamethylenetetramine ("HMTA"), under hydrogen pressure at a temperature no greater than about 160.degree. C. and in the presence of a catalytically effective amount of a hydrogenation catalyst, e.g., nickel deposited onto appropriate support substrate therefor.Type: GrantFiled: December 30, 1992Date of Patent: March 22, 1994Inventor: Stephane Fouquay
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Patent number: 5290932Abstract: Amines of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each C.sub.1 -C.sub.20 -alkyl, C.sub.3 -C.sub.20 -cycloalkyl, C.sub.4 -C.sub.20 -alkylcycloalkyl, C.sub.4 -C.sub.20 -cycloalkylalkyl, aryl, C.sub.7 -C.sub.20 -alkylaryl, C.sub.7 -C.sub.20 -aralkyl or a heterocyclic radical and n is an integer of from 3 to 7, are prepared by a process in which a ketone of the general formula II ##STR2## where R.sup.1 and R.sup.2 have the abovementioned meanings, is reacted with a cyclic amine of the general formula III ##STR3## where n has the abovementioned meanings, in the presence of a zeolite and/or SiO.sub.2 having a zeolite structure and/or a phosphate and/or a phosphate having a zeolite structure as catalysts at from 50.degree. to 500.degree. C. and from 0.01 to 50 bar.Type: GrantFiled: October 30, 1992Date of Patent: March 1, 1994Assignee: BASF AktiengesellschaftInventors: Uwe Dingerdissen, Wolfgang Hoelderich
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Patent number: 5262534Abstract: A process for preparing nonaromatic N,N,N-trisubstituted nitrogen-containing compounds which comprises heating a nonaromatic carboxylated N,N,N-trisubstituted nitrogen-containing compound at an elevated temperature for a period of time sufficient to produce the nonaromatic N,N,N-trisubstituted nitrogen-containing compound.Type: GrantFiled: June 2, 1992Date of Patent: November 16, 1993Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventor: Stephen W. King
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Patent number: 5256824Abstract: The compound (-)-N-t-butyl-4,4-diphenyl-2-cyclopentenylamine, or its hydrochloride salt has anticholinergic activity, and thus has a variety of pharmaceutical utilities.Type: GrantFiled: March 7, 1991Date of Patent: October 26, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Kazuo Okumura, Kazuhiko Take, Kazunori Tsubaki
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Patent number: 5245032Abstract: A process for preparing N,N,N-trisubstituted nitrogen-containing compounds which comprises contacting a carboxylated N,N,N-trisubstituted nitrogen-containing compound with a mixed metal oxide catalyst under conditions effective to produce the N,N,N-trisubstituted nitrogen-containing compound.Type: GrantFiled: September 20, 1990Date of Patent: September 14, 1993Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventor: Stephen W. King
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Patent number: 5141937Abstract: Pharmaceutical products containing a 7-diphenylmethylenebicycloheptane or 7-diphenylmethylenebicycloheptene derivative of the formula I ##STR1## in which A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the stated meanings, or a physiologically tolerated acid addition salt of these compounds, and the use thereof as hypolipidemics are described. In addition, new 7-diphenylmethylenebicycloheptane and -heptene derivatives of the formula Ia ##STR2## in which A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the stated meanings, and the physiologically tolerated acid addition salts thereof, as well as processes for the preparation thereof, are described.Type: GrantFiled: September 21, 1988Date of Patent: August 25, 1992Assignee: Hoechst AktiengesellschaftInventors: Herbert Siegel, Ernold Granzer
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Patent number: 5118837Abstract: A modified ruthenium catalyst can be used to selectively hydrogenate an olefinic double bond in the presence of another olefinic double bond in the same or in a different molecule. Modifiers are selected from compounds containing trivalent nitrogen, trivalent phosphorus and divalent sulfur.Type: GrantFiled: February 12, 1987Date of Patent: June 2, 1992Assignee: Givaudan CorporationInventors: Alan J. Chalk, Laszlo V. Wertheimer
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Patent number: 5095021Abstract: Phenylalkylamines of the formula ##STR1## where n is 5, 6, 7, 8 or 9, m is 1, 2 or 3, R.sup.1 is methyl, halogen, substituted or unsubstituted aryl or substituted or unsubstituted phenoxy, and, when m is 2, two adjacent radicals R.sup.1 together denote the radical ##STR2## X is oxygen, except when R.sup.1 is methyl, or the radical ##STR3## R.sup.4 is isopropyl, tert-butyl or substituted or unsubstituted phenyl and R.sup.5 is H or OH, R.sup.2 and R.sup.3 are each hydrogen and, when X is oxygen, R.sup.2 and R.sup.3 additionally denote methyl or ethyl, and their plant-tolerated salts, and fungicides containing these compounds.Type: GrantFiled: April 29, 1991Date of Patent: March 10, 1992Assignee: BASF AktiengesellschaftInventors: Matthias Zipplies, Ernst Buschmann, Eberhard Ammermann, Gisela Lorenz