Chalcogen Or Halogen Containing Substituent Patents (Class 544/215)
  • Patent number: 5446044
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: August 29, 1995
    Assignee: Warner-Lambert Company
    Inventors: Edgardo Laborde, Mel Schroeder
  • Patent number: 5442061
    Abstract: Sulfonic acid esters of 2,4-bistrichloromethyl-6-(mono- or dihydroxyphenyl)-1,3,5-triazine are disclosed. Also disclosed is a negative-working radiation-sensitive mixture containing such a compound in combination with a compound containing at least two acid-crosslinkable groups, and a water-insoluble polymeric binder which is soluble or at least swellable in aqueous alkaline solutions. The esters are esters of a sulfonic acid or sulfonic acids of the formula R--SO.sub.3 H or R'(--SO.sub.3 H).sub.2 with 2,4-bistrichloromethyl-6-(mono- or dihydroxyphenyl)-1,3,5-triazine of the formulae I and/or II ##STR1## where R is an optionally further substituted (C.sub.1 -C.sub.10)alkyl, (C.sub.5 -C.sub.10)cycloalkyl, (C.sub.6 -C.sub.10)aryl, (C.sub.6 -C.sub.10)aryl-(C.sub.1 -C.sub.10)alkyl or (C.sub.3 -C.sub.9)heteroaryl radical, R' is an optionally substituted (C.sub.1 -C.sub.10)alkylene, (C.sub.6 -C.sub.10)arylene or (C.sub.3 -C.sub.9)heteroarylene radical, and n may be 1 or 2.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: August 15, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Georg Pawlowski, Horst Roeschert, Walter Spiess, Klaus-Juergen Przybilla
  • Patent number: 5433873
    Abstract: The invention relates to novel compounds of formula I ##STR1## n is 1 or 2,R and R.sup..cndot. are each independently of the other --OR.sub.1, --SR.sub.2 or --NR.sub.3 R.sub.4,R.sub.1 is hydrogen, C.sub.1 -C.sub.30 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl or naphthyl, phenyl- or naphthyl-substituted C.sub.1 -C.sub.18 alkyl or phenyl or naphthyl which are substituted by C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy or C.sub.1 -C.sub.12 hydroxyalkyl,R.sub.2 is C.sub.1 -C.sub.30 alkyl, phenyl or naphthyl, phenyl- or naphthyl-substituted C.sub.1 -C.sub.18 alkyl or phenyl or naphthyl which are substituted by C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 alkoxy or C.sub.1 -C.sub.12 hydroxyalkyl, or is a radical of formula (CH.sub.2).sub.p --CO--OR.sub.5,p is 1 or 2,R.sub.3 and R.sub.4 have each independently of the other the meanings of R.sub.1, or --NR.sub.3 R.sub.4 is piperidyl, pyrrolidyl or azepyl, andR.sub.5 is hydrogen, C.sub.1 -C.sub.30 alkyl, C.sub.5 -C.sub.
    Type: Grant
    Filed: October 21, 1993
    Date of Patent: July 18, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Hugo Camenzind
  • Patent number: 5434267
    Abstract: Process for the preparation of compounds of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X and n have the meaning given in the description, by reacting acetates with carbon monoxide in the presence of a basic auxiliary, followed by alkylation. The products are intermediates for fungicidal acrylates.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: July 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Helmut Kraus, Alexander Klausener, Hans-Joachim Diehr
  • Patent number: 5418232
    Abstract: A compound of formula (I) possesses excellent potassium channel opening activity and is effective on various diseases arising from contractions of blood vessels, bronchial smooth muscles, etc., for example, ischemic heart diseases exemplified by angina pectoris, asthma, pollakisuria, sequela of subarachnoid hemorrhage, peripheral arterioinfarct, and so on. The compound has potent and long-lasting antihypertensive activity, with the onset of the action being slow, excellent activity in increasing renal blood flow, and high safety, and is therefore particularly useful as an antihypertensive. ##STR1## The substituents are as defined in the specification.
    Type: Grant
    Filed: May 12, 1993
    Date of Patent: May 23, 1995
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Tetsuya Mimura, Hideo Kubo
  • Patent number: 5397793
    Abstract: A class of novel heterocyclicacetonitriles which is useful in the control of fungi, especially bitunicate asci and unitunicate asd, has been discovered. These compounds are of the general formula: ##STR1## wherein Ar.sub.1 and Ar.sub.2 are substituted or unsubstituted aryl groups; Het is a six-membered nitrogen-containing heterocyclic ring; n is the integer 2 or 3; and the agronomically acceptable enantiomorphs, add addition salts and metal complexes thereof.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: March 14, 1995
    Assignee: Rohm and Haas Company
    Inventors: Steven H. Shaber, Edward M. Szapacs, Charles H. Reynolds
  • Patent number: 5378843
    Abstract: There are provided 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds, a method for the preparation thereof and the use thereof for the preparation of 5-(substituted methyl)-2,3-pyridinedicarboxylic acids.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: January 3, 1995
    Assignee: American Cyanamid Company
    Inventor: Henry L. Strong
  • Patent number: 5350449
    Abstract: 2-(2-Hydroxyphenyl)-4,6-diphenyl- and -4,6-di-p-tolyl-1,3,5-triazines are particularly suitable stabilisers, especially against light-induced degradation, for coating materials. They are superior in this respect to the corresponding 4,6-bis(2,4-dimethylphenyl) derivatives.
    Type: Grant
    Filed: January 11, 1994
    Date of Patent: September 27, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas Valet, Jean-Luc Birbaum, Mario Slongo
  • Patent number: 5347003
    Abstract: Methods are provided whereby an N-C-N compound is regenerated from a product of a sulfur scavenging reaction, in which said N-C-N compound removes a sulfur atom from a sulfur compound, to form the original N-C-N compound. The N-C-N compound is represented by the formula (I): ##STR1## The product includes a hetero compound having sulfur, carbon and nitrogen atoms in its backbone. In one embodiment, the product is mixed with (1) a nitrogen compound represented by the formula (II): ##STR2## and (2) an alkaline compound selected from alkali metal, alkaline earth metal and transition metal compounds, to form a solution, slurry or dispersion. The hetero compound is reacted with the nitrogen compound in the presence of the alkaline compound, such that a sulfur atom of the hetero compound is replaced by a nitrogen atom of the nitrogen compound. If necessary, the pH of the solution may be adjusted to about 8 to about 13 to facilitate the reaction. In alternative embodiments, the product also includes an amine complex.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: September 13, 1994
    Assignee: Quaker Chemical Corporation
    Inventors: Edward A. Trauffer, Robert D. Evans
  • Patent number: 5336676
    Abstract: Compounds of formula (I) ##STR1## wherein R is an alkyl group; R.sub.1 is a cyano, carboxy, alkoxycarbonyl or hydroxylaminocarbonyl group; R.sub.2 is substituted or unsubstituted phenyl (C.sub.3 -C.sub.7)-cycloalkyl, .alpha.-, .beta.- or .gamma.-pyridyl or a benzoheteroxcyclic ring; R.sub.3 is carboxy or carboalkoxy; Y is a group of the formula --COOX; --NHCOA; --NCO; --COA; --CONHOR.sub.e ; --OCOA; A; --COCH.sub.2 COR.sub.f ; --NHCSA; --OCSA; (a); X is hydrogen, alkyl or succinimidyl group; A is a cyclic or acyclic amino group; and n is 1 or 2; having pharmacological characteristics which render them useful in the treatment of inflammatory conditions of the respiratory tract and asthmatic conditions.
    Type: Grant
    Filed: December 4, 1992
    Date of Patent: August 9, 1994
    Assignee: Boehringer Mannheim Italia S.p.A.
    Inventors: Carmelo A. Gandolfi, Giampiero De Cillis, Giorgio Long, Licia Gallico
  • Patent number: 5326762
    Abstract: Amides of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently heteroaryl, X-substituted heteroaryl, X-substituted phenyl, N-substituted triazinyl or N-substituted imidazolyl;and in addition, one of R.sub.1 and R.sub.2 can be as defined above and the other can be phenyl;R.sub.3 is an alkyl chain of 2 to 25 carbon atoms, saturated or unsaturated; an alkyl chain as defined substituted by one or more substituents selected from the group consisting of phenyl, X-substituted phenyl, heteroaryl and X-substituted heteroaryl; an alkyl chain as defined interrupted by one or more groups independently selected from the group consisting of --O--, --S--, --SO--, --SO.sub.2 --, --NH--, --N(lower alkyl)--, --C(O)--, phenylene, X-substituted phenylene, heteroarylene and X-substituted heteroarylene; or an interrupted alkyl chain as defined substituted by one or more substituents selected form the group consisting of phenyl, X-substituted phenyl, heteroaryl and X-substituted heteroaryl;R.sub.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: July 5, 1994
    Assignee: Schering Corporation
    Inventors: John Clader, Sundeep Dugar, Timothy Kogan, Bradley Tait, Wayne Vaccaro
  • Patent number: 5298067
    Abstract: 2-(2-Hydroxyphenyl)-4,6-diphenyl- and -4,6-di-p-tolyl-1,3,5-triazines are particularly suitable stabilizers, especially against light-induced degradation, for coating materials. They are superior in this respect to the corresponding 4,6-bis(2,4 -dimethylphenyl) derivatives.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: March 29, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Andreas Valet, Jean-Luc Birbaum, Mario Slongo
  • Patent number: 5290888
    Abstract: A process for stabilizing an ethylenically unsaturated monomer or oligomer from premature polymerization is disclosed whereby a stabilizing amount of an N-hydroxy substituted hindered amine is added to said polymerizable monomer or oligomer. The ethylenically unsaturated monomer or oligomer encompass vinyl monomers or oligomers bearing at least one polymerizable moiety. The N-hydroxy substituted hindered amine inhibits premature polymerization in the liquid and/or vapor phase.
    Type: Grant
    Filed: October 2, 1992
    Date of Patent: March 1, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Leslie R. Gatechair, James L. Hyun, Peter J. Schirmann
  • Patent number: 5288866
    Abstract: There are provided 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds, a method for the preparation thereof and the use thereof for the preparation of 5-(substituted methyl)-2,3-pyridinedicarboxylic acids.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: February 22, 1994
    Assignee: American Cyanamid Company
    Inventor: Henry L. Strong
  • Patent number: 5276037
    Abstract: The invention concerns an aryl derivative of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X.sup.1 is oxy, thio, sulphinyl, sulphonyl, difluoromethylene, imino, (1-4C)alkylimino or optionally substituted (1-4C)alkylene, or X.sup.1 is a group of the formula--X.sup.4 --CR.sub.2 -- or --CR.sub.2 --X.sup.4 --whereinX.sup.4 is oxy, thio, sulphinyl, sulphonyl or carbonyl and each R is hydrogen, methyl or ethyl;each of Ar.sup.2 and Ar.sup.3 is optionally substituted phenylene;X.sup.2 is oxy, thio, sulphinyl or sulphonyl;R.sup.1 is (1-4C)alkyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.1 --X.sup.3 --A.sup.2 -- which together with the carbon atom to which A.sup.1 and A.sup.2 are attached define a ring having 5 to 7 ring atoms, wherein each of A.sup.1 and A.sup.2 is (1-3C)alkylene and X.sup.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: January 4, 1994
    Assignees: Imperial Chemical Industries PLC, ICI Pharma
    Inventors: Robert I. Dowell, Philip N. Edwards, Keith Oldham
  • Patent number: 5256748
    Abstract: Oligomers of the formula ##STR1## wherein: (1) at least one A=--CH.sub.2 CHR.sup.1 COODOH (a) (R.sup.1 =H, CH.sub.3 and D=C.sub.1 -C.sub.4 alkylene), the other A's=H or C.sub.1 -C.sub.4 alkyl, it being possible for at least a part of the residues (a) to be converted into A.sup.1 =--CH.sub.2 CHR.sup.1 COODOCONHD.sup.1 NCO (D.sup.1 =divalent organic residue), it being possible for at least a part of the residues A.sup.1 to be converted into A.sup.2 =--CH.sub.2 CHR.sup.1 COODOCONHD.sup.1 NHCOOR.sup.2 (R.sup.2 =monovalent radical obtained by removal of OH from a monoalcohol containing a vinylidene group);(2) at least one A=D.sup.2 OCONHD'.sup.1 NHCOOR'.sup.2 (b) where D.sup.2 =C.sub.1 -C.sub.4 alkylene or --D.sup.3 --(--O--D.sup.3 --).sub.n --, with D.sup.3 =C.sub.1 -C.sub.4 alkylene and n=1-12; D'.sup.1 analogous to D.sup.1 ; R'.sup.2 analogous to R.sup.2 ; the other residue(s) A denoting --D.sup.2 OCONHD'.sup.1 NCO.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: October 26, 1993
    Assignee: Autochem
    Inventors: Didier Vanhoye, Paul Grosius
  • Patent number: 5250687
    Abstract: 1,3,5-TRINITROHEXAHYDRO-1,3,5-TRIAZINE (RDX) is prepared in a new simplif and efficient manner which provides near quantitative yield. Our process is based upon the nitration of 3,7-DIACETYL 1,3,5,7 TETRAAZA[3.3.1.]BICYCLONONANE (DAPT).
    Type: Grant
    Filed: August 28, 1992
    Date of Patent: October 5, 1993
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: William J. Lukasavage, Steven Nicolich, Norman Slagg
  • Patent number: 5250528
    Abstract: This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity and represented by the general formula [I]: ##STR1## wherein R.sup.1 is lower alkyl, aryl, ar(lower)alkoxy or a heterocyclic group, each of which may be substituted with halogen,R.sup.2 is hydrogen or lower alkyl,R.sup.3 is cyclo(lower)alkyl, aryl or ar(lower)-alkyl, each of which may be substituted with halogen,A is ##STR2## or lower alkylene, and Y is ##STR3## and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: October 5, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Teruo Oku, Eishiro Todo, Yoshihiro Yokota, Hiroshi Kayakiri, Masashi Hashimoto
  • Patent number: 5238935
    Abstract: N-acyltetrahydroisoquinolines including novel compounds of the formula ##STR1## wherein R.sup.1 is a C10-C25 alkyl chain; a substituted C10-C25 alkyl chain; an interrupted C10-C25 alkyl chain; a substituted interrupted C10-C25 alkyl chain; diphenylamino; di-(R.sup.2 -substituted phenyl)amino; di-(heteroaryl)amino; di-(R.sup.2 -substituted heteroaryl)amino; diphenylmethyl; or di-(R.sup.2 -substituted phenyl)methyl;R.sup.2 is hydroxy, lower alkyl, lower alkoxy, halogeno, amino, lower alkylamino or di-(lower alkyl)amino;R.sup.3, R.sup.4 and R.sup.5 are independently H or --(CH.sub.2).sub.n --Ar;Ar is phenyl, R.sup.2 -substituted phenyl, heteroaryl or R.sup.2 - substituted heteroaryl;n=0,1 or 2;m=0,1 or 2;or a pharmaceutically acceptable salt thereof, useful in the treatment of atherosclerosis are disclosed.
    Type: Grant
    Filed: February 20, 1992
    Date of Patent: August 24, 1993
    Assignee: Schering Corporation
    Inventors: Sundeep Dugar, Timothy Kogan
  • Patent number: 5231109
    Abstract: Novel fungicides of the formula ##STR1## in which R.sup.1 represents optionally substituted hydroxyalkyl, optionally substituted hydroxyalkoxyalkyl, optionally substituted heteroarylalkyl or optionally substituted heteroaryl, andR.sup.2 represents optionally substituted alkyl, optionally substituted alkenyl, or alkinyl.Intermediates therefor, wherein R.sup.2 is hydrogen or an alkali metal cation, are also new.
    Type: Grant
    Filed: June 8, 1989
    Date of Patent: July 27, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Gayer, Klaus Jellch, Winfried Lunkenhelmer, Wilhelm Brandes, Gerd Hanssler
  • Patent number: 5231097
    Abstract: There are described new pyrimidyl-substituted acrylic esters of the general formula (I) ##STR1## in which Py, X, R.sup.1 and R.sup.2 have the meaning given in the description, a process for their preparation, and new intermediates.The compounds of the formula (I) are used as pesticides.
    Type: Grant
    Filed: August 2, 1991
    Date of Patent: July 27, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alexander Klausener, Peter C. Knuppel, Heinz-Wilhelm Dehne, Stefan Dutzmann
  • Patent number: 5229512
    Abstract: Compounds which comprise at least one group of the formula I or II ##STR1## and at least one polyalkylpiperidine group of the formula III ##STR2## in which R and R.sub.1 to R.sub.6 have the meaning indicated in claim 1, are effective stabilisers for organic materials against damage by light, oxygen and heat.
    Type: Grant
    Filed: April 15, 1991
    Date of Patent: July 20, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Mario Slongo, Jean-Luc Birbaum, Jean Rody, Andreas Valet
  • Patent number: 5216157
    Abstract: The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula IIICH.sub.3 --CO--CH.sub.2 --COOCH.sub.3 (III)and optionally with an amino compound of the general Formula IV ##STR4## (wherein Z is a group of the Formula (c), ##STR5## k is 1 and both symbols p are 0; or Z stands for a C.sub.
    Type: Grant
    Filed: April 17, 1991
    Date of Patent: June 1, 1993
    Assignee: EGIS Gyogyszergyar
    Inventors: Pal Benko, Daniel Bozsing, Laszlo Levai, Gyorgyi Kovanyi nee Lax, Gyorgy Mikite, Peter Tompe, Eva Furdyga, Ilona Dinnyes nee Nagy, Eva Poczik, Gyorgyi Zalavari nee Dosa, Ivan Beck, Istvan Simonyi, Kalman Nagy, Janos Imre, Erzsebet Kiss nee Bertok, Eva J. Tajthy nee Juhasz, Attila Mandi, Frigyes Gorgenyi
  • Patent number: 5212308
    Abstract: The invention provides a continuous moving bed reactor, useful for the prration of 3,7-diacetyl-1,3,5,7-tetraazabicyclo-3.3.1-nonane (DAPT). The reactor makes novel use of water, a known catalyst for said reaction. However, in this invention, the water is present as ice. The ice is made to automatically promote and moderate the reaction as well as regulate the flow of hexamine into the reactor. These automatic functions are achieved by mixing ice with hexamine, the latter is one of two principle reactants used, to generate a standing bed of slurry. When melted at its base, the slurry advanced under the influence of gravity. The melting of the ice being caused by local application of the second principle reactant, acetic anhydride, which is a liquid.The apparatus is constructed in the following way. A tube shaped reservoir for containing the cited slurry is open at the top end and terminates at its bottom end by a porous compartment. The latter compartment openly retains the slurry. A fluid delivery device, i.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: May 18, 1993
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: William S. Lukasavage, Seymour Portnoy, Jack Alster, Steven M. Nicolich
  • Patent number: 5199959
    Abstract: A method has been developed to solubilize hydroxy S-triazines containing at least one hydroxy function in diesel fuel and to enhance their overall thermal stability. The products which result from the full or partial encapsulation of hydroxy-S-triazine with calix[8]arene have unique and novel properties and reduce or eliminate nitrogen oxides level in diesel fuel.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: April 6, 1993
    Assignee: Texaco Inc.
    Inventors: Rodney L. Sung, Thomas F. Derosa, Benjamin J. Kaufman
  • Patent number: 5182360
    Abstract: Tris(norbornenyl) isocyanurate compounds of the formula: ##STR1## wherein R.sup.1 is either H or methyl group, are prepared from the base-catalyzed trimerization of norbornenyl isocyanate. Tris(norbornenyl) isocyanurate is suitable for use as a crosslinker in thiol-ene formulations containing a difunctional thiol oligomer or in systems containing norbornene-difunctional oligomers and polyfunctional thiols, producing improved high temperature properties for the cured compositions.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: January 26, 1993
    Assignee: Loctite Corporation
    Inventors: Anthony F. Jacobine, Steven T. Nakos
  • Patent number: 5179104
    Abstract: An asymmetric process for the preparation of enantiomerically pure .beta.-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of the nucleosides. The anti-viral activity of the compounds is surprising in light of the generally accepted theory that moieties in the endo conformation, including these dioxolanes, are not effective antiviral agents. The toxicity of the enantiomerically pure dioxolane nucleosides is lower that that of the racemic mixture of the nucleosides, because the nonnaturally occurring .alpha.-isomer is not included.The product can be used as a research tool to study the inhibition of HIV in vitro or can be administered in a pharmaceutical composition to inhibit the growth of HIV in vivo.
    Type: Grant
    Filed: December 5, 1990
    Date of Patent: January 12, 1993
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Chung K. Chu, Raymond F. Schinazi
  • Patent number: 5158954
    Abstract: Fungicidal compounds of the formula (I): ##STR1## and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is O, S(O).sub.n, NR.sup.4, CR.sup.1 R.sup.2, CHR.sup.5, CO, CR.sup.1 (OR.sup.2), C.dbd.CR.sup.1 R.sup.2, CHR.sup.1 CHR.sup.2, CR.sup.1 .dbd.CR.sup.2, CHR.sup.1 CR.sup.2 .dbd.CH, C.dbd.C, OCHR.sup.1, CHR.sup.1 O, OCHR.sup.1 O, S(O).sub.n CHR.sup.1, S(O).sub.n CHR.sup.1 O, CHR.sup.1 S(O).sub.n, CHR.sup.1 OSO.sub.2, NR.sup.4 CHR.sup.1, CHR.sup.1 NR.sup.4, CO.sub.2, O.sub.2 C, SO.sub.2 O, OSO.sub.2, CO.CO, COCHR.sup.1, COCHR.sup.1 O, CHR.sup.1 CO, CHOH.CHR.sup.1, CHR.sup.1.CHOH, ##STR2## CONR.sup.4, OCONR.sup.4, NR.sup.4 CO, CSNR.sup.4, OCS.NR.sup.4, SCO.NR.sup.4, NR.sup.4 CO.sub.2, NR.sup.4 CS, NR.sup.4 CSO, NR.sup.4 COS, NR.sup.4 CONR.sup.4, S(O).sub.n NR.sup.4, NR.sup.4 S(O).sub.n, CS.sub.2, S.sub.2 C, CO.S, SCO, N.dbd.N, N.dbd.CR.sup.1, CR.sup.1 .dbd.N, CHR.sup.1 CHR.sup.2 CH(OH), CHR.sup.1 OCO, CHR.sup.1 SCO, CHR.sup.1 NR.sup.
    Type: Grant
    Filed: October 15, 1990
    Date of Patent: October 27, 1992
    Assignee: Imperial Chemical Industries PLC
    Inventors: John M. Clough, Christopher R. A. Godfrey, Stephen P. Heaney, Kenneth Anderton
  • Patent number: 5145954
    Abstract: Compounds of formula: ##STR1## and stereoisomers thereof, wherein R.sup.1 and R.sup.2, which are the same or different, are optionally substituted alkyl; W, X, Y and Z, which are the same or different, are hydrogen, halogen, hydroxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted aryloxyalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted alkynyl, optionally substituted amino, optionally substituted arylazo, optionally substituted heteroarylalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted acylamino, nitro, cyano, --OR.sup.3, --SR.sup.3, --CO.sub.2 R.sup.4, --CONR.sup.5 R.sup.6, --COR.sup.7, --CR.sup.8 .dbd.NR.sup.9, --N.dbd.CR.sup.10 R.sup.11, --SOR.sup.12 or --SO.sub.2 R.sup.
    Type: Grant
    Filed: April 17, 1989
    Date of Patent: September 8, 1992
    Assignee: Imperial Chemical Industries PLC
    Inventors: Vivienne M. Anthony, John M. Clough, Paul DeFraine, Christopher R. A. Godfrey, Thomas E. Wiggins, David J. Tapolczay
  • Patent number: 5143648
    Abstract: This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.
    Type: Grant
    Filed: August 20, 1991
    Date of Patent: September 1, 1992
    Assignee: Nippon Hypox Laboratories Incorporated
    Inventors: Toshio Satoh, Yasunori Niiro, Hisao Kakegawa, Hitoshi Matsumoto
  • Patent number: 5134148
    Abstract: The invention concerns a heterocycle of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms;A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene;X is oxy, thio, sulphinyl, sulphonyl or imino;Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl;and R.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which, together with the carbon atom to which A.sup.2 and A.sup.3 are attached, defines a ring having 4 to 7 ring atoms, wherein A.sup.2 and A.sup.3, which may be the same or different, each is (1-4C)alkylene and X.sup.
    Type: Grant
    Filed: September 5, 1991
    Date of Patent: July 28, 1992
    Assignees: Imperial Chemical Industries PLC, ICI Pharma
    Inventors: Graham C. Crawley, Philip N. Edwards, Jean-Marc M. M. Girodeau
  • Patent number: 5124337
    Abstract: N-acyltetrahydroisoquinolines including novel compounds of the formula ##STR1## wherein R.sup.1 is a C10-C25 alkyl chain; a substituted C10-C25 alkyl chain; an interrupted C10-C25 alkyl chain; a substituted interrupted C10-C25 alkyl chain; diphenylamino; di-(R.sup.2 -substituted phenyl)amino; di-(heteroaryl)amino; di-R.sup.2 -substituted heteroary)amino; diphenylmethyl; or di-(R.sup.2 -substituted phenyl)methyl;R.sup.2 is hydroxy, lower alkyl, lower alkoxy, halogeno, amino, lower alkylamino or di-(lower alkyl)amino;R.sup.3, R.sup.4 and R.sup.5 are independently H or --(CH.sub.2 .sub.n --Ar;Ar is phenyl, R.sup.2 -substituted phenyl, heteroaryl or R.sup.2 -substituted heteroaryl;n=0,1 or 2;m=0,1 or 2;or a pharmaceutically acceptable salt thereof, useful in the treatment of atherosclerosis are disclosed.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: June 23, 1992
    Assignee: Schering Corporation
    Inventors: Sundeep Dugar, Timothy Kogan
  • Patent number: 5116405
    Abstract: A pyridinesulfonamide derivative of the formula (I) and a salt thereof: ##STR1## wherein R.sup.1 is a halogen atom, a trifluoromethyl group, a C.sub.1 -C.sub.6 alkoxycarbonyl group, a C.sub.1 -C.sub.6 mono- or di-alkylaminocarbonyl group, a C.sub.1 -C.sub.6 alkxoy group, a C.sub.1 -C.sub.6 alkylsulfonyl group, a C.sub.1 -C.sub.6 alkylthio group, a C.sub.1 -C.sub.6 alkyl group substituted by a C.sub.1 -C.sub.6 alkoxy group, a C.sub.1 -C.sub.6 alkyl group substituted by a C.sub.1 -C.sub.6 mono- or poly-halogenoalkoxy group, a C.sub.1 -C.sub.6 mono- or poly-halogenoalkoxy group, a C.sub.1 -C.sub.6 mono- or di-alkylaminosulfonyl group, a C.sub.1 -C.sub.6 alkoxyaminosulfonyl group substituted by a C.sub.1 -C.sub.6 alkyl group, a nitro group, a C.sub.1 -C.sub.6 alkyl group substituted by a C.sub.1 -C.sub.6 alkylthio group, a C.sub.1 -C.sub.5 alkyl group substituted by a C.sub.1 -C.sub.6 alkylsulfonyl group, or a C.sub.1 -C.sub.6 alkyl group substituted by a C.sub.1 -C.sub.6 alkoxycarbonyl group;R.sup.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: May 26, 1992
    Assignee: Nissan Chemical Industries Ltd.
    Inventors: Kenzi Makino, Katsushi Morimoto, Shigeaki Akiyama, Hideaki Suzuki, Takeshi Nagaoka, Koichi Suzuki, Tsutomu Nawamaki, Shigeomi Watanabe
  • Patent number: 5115042
    Abstract: Ortho ester-capped polyphenylene ethers are prepared by the reaction of a polyphenylene ether with a reactive compound containing an ortho ester group, preferably a 4-(2-methoxy-2-methyl-1,3-dioxolan-4-yl)methyl group. Chlorotriazines containing the ortho ester substituent are particularly preferred as capping agents. The capped polyphenylene ethers form copolymer-containing compositions with polyamides and other polymers containing amine groups, particularly in the presence of a Lewis acid as catalyst.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: May 19, 1992
    Assignee: General Electric Company
    Inventors: Farid F. Khouri, Sterling B. Brown, John T. Jackman
  • Patent number: 5110986
    Abstract: This application relates to a process for preparing a N-t-alkyl-1,2-diacylhydrazine by reacting a 1,3,4-oxadiazole with a tertiary alkyl cation precursor in the presence of a strong acid catalyst. Preferably, the 1,3,4-oxadiazole is a 2,5-disubstituted-1,3,4-oxadiazole and more preferably a 2,5-diaryl-1,3,4-oxadiazole. The strong acid catalyst is preferably a sulfur containing acid and more preferably sulfuric acid.
    Type: Grant
    Filed: April 26, 1988
    Date of Patent: May 5, 1992
    Assignee: Rohm and Haas Company
    Inventor: Martha J. Kelly
  • Patent number: 5099008
    Abstract: A process for producing very-fine crystals of a nitramine explosive selec from HMX and RDX or mixtures thereof, said crystals having a positive surface charge and being sufficiently stable to shock and to impact to meet military standards as well as having acceptable explosive power and having desirable high density.
    Type: Grant
    Filed: May 20, 1991
    Date of Patent: March 24, 1992
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: H. William Voigt, Jr., Bernard Strauss
  • Patent number: 5089044
    Abstract: The invention relates to new substituted pyrimidinyloxy(thio)- and triazinyloxy(thio)acrylic acid derivative of general formula I ##STR1## in which A, G, R.sup.1-3, X and Y have the meanings given in the description, processes for their preparation and their use as herbicides, fungicides and plant growth regulants.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: February 18, 1992
    Assignee: Schering Aktiengesellschaft
    Inventors: Christoph Harde, Erhard Nordhoff, Anita Kruger, Gabriele Kruger, Gerhard Tarara, Peter Wegner, Nikolaus Heinrich, Clemens Kotter, Gerhard Johann, Richard Rees
  • Patent number: 5089567
    Abstract: Substituted alkoxy- or alkylthiochlorotriazines wherein the substituents on the alkoxy groups are chlorine, bromine or dialkylphosphato are useful as capping agents for polyphenylene ethers. The capped polyphenylene ethers form copolymers with other polymers containing nucleophilic groups, including polyesters, polyamides and functionalized olefin polymers. Such copolymers serve as compatibilizers in the formation of blends having high impact strength.
    Type: Grant
    Filed: February 11, 1991
    Date of Patent: February 18, 1992
    Assignee: General Electric Company
    Inventors: Otto Phanstiel, Sterling B. Brown
  • Patent number: 5079361
    Abstract: Cross-linking reagents which are highly specific for sulphydryl groups and react with thiols at an excellent rate. The essential feature of the reagents is at least one vinyl group conjugated with an armoatic nitrogen heterocycle. Particular examples include vinyl pyridines, vinyl pyrimidines and vinyl triazines.
    Type: Grant
    Filed: September 9, 1988
    Date of Patent: January 7, 1992
    Assignee: Celltech Limited
    Inventors: Rikki P. Alexander, Michael A. W. Eaton, Thomas A. Millican, Richard C. D. Titmas
  • Patent number: 5057563
    Abstract: Substituted aminoxy propionamide derivatives corresponding to the formula ##STR1## said derivatives being useful as color improvers and stabilizers in various polymeric substrates.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: October 15, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Ramanathan Ravichandran
  • Patent number: 5053505
    Abstract: A staged process is disclosed for forming a tri-substituted triazine ring in which the substituents are cyclic amines referred to as hindered amines. A prior art process for making such amines in a reaction mixture of aqueous and organic phases has been modified to produce a stabilizer with desirable whiteness, at the same time avoiding the loss of the cyclic amine reactant which is water-soluble. Conversion of the amine to yield at least 90% of the tri-substituted product having at least 90% purity allows the reaction to be commercially significant despite the high cost of the reactants. The staged process is preferably conducted in two sequences in two reactors, with an intermediate step in which the aqueous saline and basic solution from the first sequence is withdrawn. In the first sequence, a mono-chloro intermediate ("MCI") is formed at ambient temperature, but below 100.degree. C. to yield a colored solution.
    Type: Grant
    Filed: May 21, 1990
    Date of Patent: October 1, 1991
    Assignee: The B. F. Goodrich Company
    Inventors: Pyong N. Son, John T. Lai, Ronald M. Kovach
  • Patent number: 5011860
    Abstract: Aryl-substituted naphthyridines and pyridopyrazines are disclosed which are useful in treating allergic reactions, inflammation, peptic ulcers and/or hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.
    Type: Grant
    Filed: June 26, 1989
    Date of Patent: April 30, 1991
    Assignee: Schering Corporation
    Inventors: David J. Blythin, Ho-Jane Shue
  • Patent number: 5010144
    Abstract: Substituted alkoxy-or alkylthiochlorotriazines wherein the substituents on the alkoxy groups are chlorine, bromine or dialkylphosphato are useful as capping agents for polyphenylene ethers. The capped polyphenylene ethers form copolymers with other polymer containing nucleophilic groups, including polyesters, polyamides and functionalized olefin polymers. Such copolymers serve as compatibilizers in the formation of blends having high impact strength.
    Type: Grant
    Filed: June 7, 1990
    Date of Patent: April 23, 1991
    Assignee: General Electric Company
    Inventors: Ott Phanstiel, IV, Sterling B. Brown
  • Patent number: 5002694
    Abstract: Nitrogen-containing heterocyclic compounds of the formula II ##STR1## wherein R.sup.1 and R.sup.2 in each case denote an alkyl group having 1 to 15 C atoms, wherein one or more CH.sub.2 groups may also be replaced by a grouping selected from the group comprising --O--, --S--, --CO--, --O--CO--, --O--COO--, --CO--O--, --CH.dbd.CH--, --CH--halogen and --CHCN--, or else by a combination of two suitable groupings, two heteroatoms not being directly linked to each other,m denotes 0 or 1,Ar denotes 1,4-phenylene, 4,4'-biphenylyl or 2,6-naphthylene, wherein one or more CH groups are in each case replaced by N,Z denotes --C--O--, --O--CO--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CHCN--, --CHCNCH.sub.2 --, --CH.dbd.CH or a single bond, andA denotes unsubstituted 1,4-cyclonexylene or 11,4-cyclohexylene substituted in position 1 or position 4 by CN,with the proviso that if A=unsubstituted 1,4-cyclonexylene, Z denotes --CHCNCH.sub.2 -- or --CH.sub.2 CHCN-- and/or at least one CH.sub.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: March 26, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Andreas Wachtler, Rudolf Eidenschink, Joachim Krause, Bernhard Scheuble
  • Patent number: 5001138
    Abstract: Novel insecticides of the formula ##STR1## in which n is 0 or 1,X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R.sup.9 variously represent hydrogen or specified organic radicals.
    Type: Grant
    Filed: May 4, 1989
    Date of Patent: March 19, 1991
    Assignee: Nihon Tokushu Noyaku Seizo, K.K.
    Inventors: Kozo Shiokawa, Shinichi Tsuboi, Shinzo Kagabu, Koichi Moriya
  • Patent number: 4985426
    Abstract: There is disclosed a compound represented by the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a lower alkyl group; R.sub.2 and R.sub.3 each independently represent a halogen atom or a lower alkyl group; R.sub.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: January 15, 1991
    Assignees: UBE Industries, Ltd., The Institute of Physical and Chemical Research
    Inventors: Hirosuke Yoshioka, Tokio Obata, Katsutoshi Fujii, Kiyoshi Tsutsumiuchi, Haruo Yoshiya
  • Patent number: 4983734
    Abstract: Cyclic nitramines of the formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of H, NO and NO.sub.2, and acid salts of the compound in which R.sup.1, R.sup.2 and R.sup.3 are each H, are disclosed. These compounds are useful as components in energetic compositions, including rocket and gun propellants and explosives, and are of particular interest due to their combination of high energy output and insensitivity. Compounds in which R.sup.3 is H or NO are further useful as intermediates in the preparation of those in which R.sup.3 is NO.sub.2. Also disclosed is a method for producing such compounds involving the reaction between hexamethylenetetramine and nitroguanidine.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: January 8, 1991
    Assignee: Aerojet General Corporation
    Inventors: Der-Shing Huang, Renato R. Rindone
  • Patent number: 4958022
    Abstract: Polycyclic compounds of the general formula (I) ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, alkyl, cycloalkyl, unsubstituted or substituted phenyl, pyridyl or phenylalkyl, or R.sup.1 and R.sup.2 together form a trimethylene or tetramethylene group, W, X, Y and Z independently of one another are each C--R.sup.6 or nitrogen, one or more of the radicals W, X, Y or Z being C--R.sup.6, R.sup.6 is hydrogen, --CO.sub.2 R.sup.7, --CONR.sup.7 R.sup.8, cyano or hydroxymethyl and R.sup.7 and R.sup.8 are each hydrogen, alkyl, unsubstituted or substituted phenyl, cycloalkyl, a 5-membered or 6-membered heterocyclic structure or phenylalkyl, R.sup.3 and R.sup.4 are each hydrogen or R.sup.3 and R.sup.4 together form a group of the formula ##STR2## A is a chemical bond, alkylene, ##STR3## or cycloalkylene, m and o are each from 1 to 20, R.sup.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: September 18, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Alexander Aumueller, Peter Neumann, Hubert Trauth
  • Patent number: 4948795
    Abstract: This invention provides pyridylthiazolidine carboxamide derivative shown by general formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A.sup.1 is a single bond, carbonyl group or lower alkylene group which may include a carbonyl group and R.sup.1 is a heterocyclic ring which may be substituted with a lower alkyl group and further provides N-substituted piperazine derivatives useful as intermediates for preparing said compounds (I).
    Type: Grant
    Filed: April 12, 1989
    Date of Patent: August 14, 1990
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Toshiyasu Mase, Hiromu Hara, Toshimitsu Yamada
  • Patent number: 4927925
    Abstract: Compounds of formula (I) ##STR1## in which R.sub.1 is hydrogen, O.sup.., CN, NO, cyanomethyl, C.sub.1 -C.sub.12 -alkyl, C.sub.3 -C.sub.12 -alkenyl or C.sub.3 -C.sub.12 -alkynyl subject to the proviso that the carbon atom attached to the nitrogen atom is a primary carbon atom, C.sub.7 -C.sub.12 -aralkyl, C.sub.1 -C.sub.12 -acyl, 2,3-epoxypropyl, OH-monosubstituted C.sub.2 -C.sub.6 -alkyl or 2,3-dihydroxypropyl, R.sub.2 is hydrogen, C.sub.1 -C.sub.18 -alkyl, C.sub.5 -C.sub.18 -cycloalkyl, C.sub.6 -C.sub.18 -aryl or C.sub.7 -C.sub.18 -aralkyl, R.sub.3 is C.sub.6 -C.sub.18 -aryl or a group of the formula (II) ##STR2## in which R.sub.1 is as defined above, n is an integer from 1 to 4 and R.sub.4 is an organic or inorganic radical of a valency equal to n are useful for stabilizing organic material against oxidative, thermal and/or light induced degradation.
    Type: Grant
    Filed: October 13, 1988
    Date of Patent: May 22, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Giuseppe Cantatore, Valerio Borzatta