Additional Hetero Ring Which Is Unsaturated Patents (Class 544/310)
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Patent number: 6534651Abstract: The invention provides a novel class of substituted isoindolinone derivatives, useful for the treatment of inflammation and reperfusion injuries. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, stereoisomers or mixtures thereof are also described. The novel isoindolinone derivatives have the formula: or a pharmaceutically acceptable base or acid addition salt, hydrate, stereoisomer, or mixtures thereof, wherein R14 is described herein.Type: GrantFiled: January 19, 2001Date of Patent: March 18, 2003Assignee: Inotek Pharmaceuticals Corp.Inventors: Prakash Jagtap, Garry Southan, Andrew Salzman, Csaba Szabo, Siya Ram
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Publication number: 20030045717Abstract: The invention relates to compounds based on merocyanines with the general formulas I and/or II, 1Type: ApplicationFiled: July 3, 2002Publication date: March 6, 2003Applicant: Dyomics GmbHInventors: Peter Czerney, Matthias Wenzel, Wilhelm Frank, Frank Lehmann
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Patent number: 6528513Abstract: Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.Type: GrantFiled: December 15, 2000Date of Patent: March 4, 2003Assignee: Tularik INCInventors: Timothy D. Cushing, Heather L. Mellon, Juan C. Jaen, John A. Flygare, Shi-Chang Miao, Xiaoqi Chen, Jay P. Powers
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Patent number: 6525200Abstract: Multicyclic aromatic compounds useful as complexing agents having the general formula: Methods of complexing and quantitating a component in a sample such as urea or guanidine are also disclosed.Type: GrantFiled: August 10, 2000Date of Patent: February 25, 2003Assignee: Roche Diagnostics CorporationInventors: Alisher B. Khasanov, Thomas W. Bell
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Patent number: 6525050Abstract: Compounds of the formula: (where R1, R2 and R3 are defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases such as cancer.Type: GrantFiled: March 1, 2001Date of Patent: February 25, 2003Assignee: Agouron Pharmaceuticals, Inc.Inventors: William H. Romines, III, Michael D. Varney, Cynthia L. Palmer, Ted M. Bleckman
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Patent number: 6525197Abstract: The present invention relates to methods for preparing macrocyclic products having 9 or more ring atoms by ring-closing diyne metathesis of suitable diyne substrates. The diyne substrates can be converted into cycloalkynes or into cycloalkadiynes by cyclodimerization, depending on the particular reaction conditions. Any alkyne metathesis catalyst can be used as the catalyst, regardless of whether said catalysts are heterogeneously or homogeneously present in the reaction medium. The preferred catalysts or pre-catalysts are transition metal alkylidyne complexes, transition metal compounds which form alkylidyne complexes under the reaction conditions, and transition metal compounds with metal-metal triple bonds. The method can be carried out with numerous functional groups, solvents, and additives.Type: GrantFiled: August 4, 2000Date of Patent: February 25, 2003Assignee: Studiengesellschaft Kohle mbHInventors: Alois Fürstner, Günter Seidel, Antonio Rumbo, Christian Mathes
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Patent number: 6525051Abstract: N-Heterocyclic derivatives selected from the group consisting of the following formulae: where Z1, Z2, Z3, R1, R2, R3, R4, R5 and R6 are described herein, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.Type: GrantFiled: March 22, 2001Date of Patent: February 25, 2003Assignee: Schering AktiengesellschaftInventors: David D. Davey, Eric Pham, Gary B. Phillips, Wei Xu
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Patent number: 6518425Abstract: Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.Type: GrantFiled: May 15, 2000Date of Patent: February 11, 2003Assignees: Emory University, Triangle Pharmaceuticals, Inc.Inventors: George R. Painter, Dennis C. Liotta, Merrick R. Almond, Darryl G. Cleary, Josè D. Soria, Marcos Sznaidman
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Patent number: 6506738Abstract: The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the treatment of respiratory syncytial virus infection.Type: GrantFiled: September 14, 2001Date of Patent: January 14, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Kuo-Long Yu, Rita Civiello, Keith Combrink, Hatice Belgin Gulgeze, Bradley C. Pearce, Xiangdong Wang, Nicholas A. Meanwell, Yi Zhang
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Publication number: 20020198381Abstract: The novel compounds of formula I: 1Type: ApplicationFiled: March 21, 2002Publication date: December 26, 2002Applicant: Intellectual Property Department BASF AktiengesellschaftInventors: Stefan Scheiblich, Thomas Maier, Helmut Siegfried Baltruschat, Thomas Hoellmueller
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Patent number: 6495491Abstract: The invention relates to novel substituted cyanophenyluracils of the general formula (I) in which R1, R2, R3, R4, R5 and Q are each as defined in the description, to processes for their preparation, to novel intermediates and to their use as herbicides and insecticides.Type: GrantFiled: December 22, 1997Date of Patent: December 17, 2002Assignees: Bayer Aktiengesellschaft, Nihon Bayer Agrochem K.K.Inventors: Roland Andree, Mark Wilhelm Drewes, Otto Schallner, Markus Dollinger, Hans-Joachim Santel, Christoph Erdelen, Akihiko Yanagi, Toshio Goto
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Publication number: 20020183502Abstract: Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.Type: ApplicationFiled: May 24, 2002Publication date: December 5, 2002Inventors: Alain De Mesmaeker, Jacques Lebreton, Adrian Waldner, Phillip Dan Cook
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Patent number: 6472384Abstract: The present invention relates to ester, ether and N-alkylcarbamoyl derivatives of compound (Ia) and pharmaceutically acceptable salts thereof. These compounds exhibit excellent antibacterial activity and are useful for the treatment or prevention of bacterial infections. (wherein R1 is a hydrogen atom or a methyl group; R2a is a hydrogen atom, a protecting group for a hydroxy group, or a methyl group; R3 is a hydrogen atom or a protecting group for a hydroxy group; R4a is a hydrogen atom, a hydroxy group or a protected hydroxy group; R5 is a hydrogen atom or a protecting group for a hydroxy group; and X is a methylene group or a sulfur atom). The invention also includes compounds which are related to the aforeidentified compounds.Type: GrantFiled: January 9, 2001Date of Patent: October 29, 2002Assignee: Sankyo Company, LimitedInventors: Masatoshi Inukai, Masakatsu Kaneko, Toshio Takatsu, Hitoshi Hotoda, Masatoshi Arai, Shunichi Miyakoshi, Masaaki Kizuka, Yasumasa Ogawa
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Patent number: 6465476Abstract: The present invention pertains to the field of medicine and more precisely relates to a novel immuno-modulator of the following formula which exhibits anti-microbial and anti-mycobacterial activities. This modulator is produced by reacting equimolecular amount of 6-methyluracyl-5-sulphochloride and isoniazide in acetonitrile at a high temperature. The preparation is practically not toxic (LD50 in severe conditions exceeding 7000 mg/kg) and can be used according to a given clinical tests for expressing the immuno-modulating and anti-mycobacterial activity. This preparation can be used for correcting various immuno-deficiencies including in HIV-infected patients as well as for treating mycobacterioses such as leprosy, tuberculosis, etc. This preparation can be administrated internally or parenterally.Type: GrantFiled: February 14, 2000Date of Patent: October 15, 2002Inventors: Nikolai Mikhailovich Goloschapov, Elena Nikolaevna Goloschapova, Tamara Petrovna Filipskikh, Elena Andreevna Michurina, Ljubov Elizarovna Kostjuk, Rakhim Musaevich Khaitov, Galina Ivanovna Tsyvkina, Vladimir Kuzmich Grishin, Nikolai Alexandrovich Stukalov
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Publication number: 20020147200Abstract: A compound of the general formula (I): 1Type: ApplicationFiled: November 20, 2001Publication date: October 10, 2002Inventor: Bjorn M. Nilsson
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Patent number: 6458952Abstract: The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.Type: GrantFiled: May 18, 2000Date of Patent: October 1, 2002Assignee: Pharmacia CorporationInventors: Michael South, Darin E. Jones, Melvin L. Rueppel
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Publication number: 20020137933Abstract: The compounds of formula (I) 1Type: ApplicationFiled: March 8, 2002Publication date: September 26, 2002Inventors: Volker Breu, Philippe Coassolo, Werner Neidhart, Sebastien Roux, Peter Weiss
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Patent number: 6455697Abstract: The invention relates to novel substituted phenyluracils of the general formula (I) in which R1, R2, R3, R4, R5 and R6 are each as defined in the description, to processes for their preparation, to novel intermediates and to their use as herbicides.Type: GrantFiled: January 16, 2001Date of Patent: September 24, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Markus Dollinger, Hans-Joachim Santel
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Publication number: 20020132820Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.Type: ApplicationFiled: January 25, 2001Publication date: September 19, 2002Applicant: Neurocrine Biosciences, Inc.Inventors: Yun-Fei Zhu, Chen Chen, Fabio C. Tucci, Zhiqiang Guo, Timothy D. Gross, Martin Rowbottom, R. Scott Struthers
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Publication number: 20020132821Abstract: The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.Type: ApplicationFiled: July 20, 2001Publication date: September 19, 2002Inventors: Peter Emig, Eckhard Gnther, Bernd Nickel, Gerald Bacher, Silke Baasner, Thomas Beckers, Beate Aue
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Patent number: 6451738Abstract: The invention relates to novel substituted thienyl(amino)sulphonyl(thio)ureas of the formula (I) in which A represents nitrogen or a CH grouping, E represents a single bond or an NH grouping, Q represents oxygen or sulphur, R1 and R2 independently of one another represent hydrogen, halogen or in each case optionally substituted alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy, aryloxy or heterocyclyloxy, R3 represents hydrogen or optionally substituted alkyl, R4 and R5 independently of one another each represent cyano, halogen or represent in each case optionally substituted alkyl, alkoxy, alkenyl, alkenyloxy, alkinyl or alkinyloxy, and R6 represents hydrogen, cyano, halogen or represents in each case optionally substituted alkyl, alkoxy, alkenyl, alkenyloxy, alkinyl or alkinyloxy, and to salts of compounds of the formula (I), to processes for preparing the novel compounds and to their use as herbicides.Type: GrantFiled: August 9, 2001Date of Patent: September 17, 2002Assignee: Bayer AktiengesellschaftInventors: Ernst Rudolf F. Gesing, Johannes Rudolf Jansen, Klaus-Helmut Müller, Ulrich Philipp, Markus Dollinger
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Patent number: 6448203Abstract: The invention relates to novel substituted aryluracils of the formula (I): to processes for their preparation and to their use as crop protection agents.Type: GrantFiled: October 7, 1999Date of Patent: September 10, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Markus Dollinger, Christoph Erdelen
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Publication number: 20020123502Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.Type: ApplicationFiled: December 26, 2001Publication date: September 5, 2002Applicant: DR. REDDY'S RESEARCH FOUNDATION & REDDY-CHEMINOR, INC.Inventors: Vidya Bhushan Lohray, Braj Bhushan Lohray, Rao Bheema Paraselli, Ranga Madhavan Gurram, Rajagopalan Ramanujam, Ranjan Chakrabarti, Sarma K.S. Pakala
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Patent number: 6444616Abstract: The invention relates to novel substituted p-trifluoromethylphenyluracils of the general formula (I) in which R1, R2, R3, R4 and R5 are each as defined in the description, to a process for their preparation and to their use as herbicides.Type: GrantFiled: August 1, 2000Date of Patent: September 3, 2002Assignee: Bayer AktiengesellschaftInventors: Mark-Wilhelm Drewes, Roland Andree, Markus Dollinger
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Publication number: 20020111354Abstract: The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.Type: ApplicationFiled: July 20, 2001Publication date: August 15, 2002Inventors: Peter Emig, Eckhard Gnther, Bernhard Kutscher, Bernd Nickel, J?uuml;rgen Schmidt, Anita Storch
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Publication number: 20020111274Abstract: There is provided a uracil substituted 1-phenylbenzotriazole compound having the structural formula I.Type: ApplicationFiled: July 11, 2001Publication date: August 15, 2002Applicant: BASF AktiengesellschaftInventors: Robert E. Diehl, Susan Trotto, Michael Anthony Guaciaro, Peter John Wepplo
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Patent number: 6433134Abstract: Novel and efficient syntheses create novel piperazinone intermediates which facilitate the production and use of PNAs. Such syntheses and the products enhance the feasibility of a system which permits the rapid identification of PNA oligomers useful as therapeutics, diagnostics and/or gene characterization tools. A first component of the system is a universal PNA library that most preferably incorporates one or more universal nucleotide bases into carefully selected positions within each oligomer species thereby providing the library with the screening ability of a much larger library. The second component of the system is a high throughput screening system that includes a number of assays designed to provide information on the binding activities of the different PNAs to a target nucleotide sequence (generally, a DNA or RNA sequence).Type: GrantFiled: January 5, 2000Date of Patent: August 13, 2002Assignee: Biocept, Inc.Inventors: Andrew P. Patron, Azra Pervin
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Patent number: 6432879Abstract: The invention relates to novel substituted phenyluracils of the general formula (I) in which the radicals n, Q, R1 to R6 are each as defined in the description, and to processes for this preparation and to their use as herbicides.Type: GrantFiled: May 23, 2000Date of Patent: August 13, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Patent number: 6432963Abstract: Pyrimidine-5-carboxamide derivatives represented by a general formula (I) or salts thereof [wherein each symbol has the following meaning; X: O, S, NR1, CO, NR1CO, CONR1, C═N—OR1 or a bond, Y: a lower alkylene group which may be substituted by OR1 or —NHR1, or a bond, Z: O, NR2 or a bond, A: H, or a lower alkyl which may have a substituent, a —CO-lower alkyl which may have a substituent, an aryl which may have a substituent, a heteroaryl which may have a substituent, a cycloalkyl which may have a substituent or a nitrogen-containing saturated heterocyclic group which may have a substituent, B: an aryl which may have a substituent or a heteroaryl group which may have a substituent, R1, R2: H, a lower alkyl or a —CO-lower alkyl group].Type: GrantFiled: June 15, 2000Date of Patent: August 13, 2002Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiroyuki Hisamichi, Ryo Naito, Souichirou Kawazoe, Akira Toyoshima, Kazuhito Tanabe, Eiichi Nakai, Atsushi Ichikawa, Akiko Orita, Makoto Takeuchi
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Publication number: 20020103214Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.Type: ApplicationFiled: July 20, 2001Publication date: August 1, 2002Inventors: Peter Emig, Eckhard Gnther, J?uuml;rgen Schmidt, Bernd Nickel, Bernhard Kutscher
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Patent number: 6420130Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods.Type: GrantFiled: April 28, 1999Date of Patent: July 16, 2002Assignee: Aurora Biosciences CorporationInventors: Lewis R. Makings, Gregor Zlokarnik
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Publication number: 20020091116Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.Type: ApplicationFiled: February 28, 2001Publication date: July 11, 2002Inventors: Bing-Yan Zhu, Zhaozhong Jon Jia, Wenrong Huang, Yonghong Song, James Kanter, Robert M. Scarborough
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Patent number: 6417192Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.Type: GrantFiled: June 28, 2000Date of Patent: July 9, 2002Assignee: SmithKline Beecham p.l.c.Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
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Patent number: 6417141Abstract: The invention relates to novel aminouracils of the general formula (I) in which, Q, R1, R2, R3, R4, R5, R6 and R7 are each as defined in the description, to their use as herbicides and to novel intermediates.Type: GrantFiled: January 21, 1998Date of Patent: July 9, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Otto Schallner, Markus Dollinger, Hans-Joachim Santel
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Patent number: 6410484Abstract: A 5,6-dihydrouracil compound given by the formula [I]: wherein, R1 represents C1-C2 haloalkyl group and Q represents Q1 of the formula below, etc.: wherein, R3 is hydrogen atom or halogen atom, R15 is C3-C6 alkynyl group, etc., Z is oxygen atom, sulfur atom or NH group, and T is direct bond or methylene group, has an excellent herbicidal efficacy.Type: GrantFiled: October 30, 2000Date of Patent: June 25, 2002Assignee: Sumitomo Chemical Company, LimitedInventors: Minoru Takano, Hirofumi Mishima
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Patent number: 6399620Abstract: There are described cycloalkyl derivatives of the formula (I) R1—Y—A—B—D—E—F—G (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.Type: GrantFiled: June 29, 2000Date of Patent: June 4, 2002Assignee: Aventis Pharma S.A.Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Richard Gadek, Robert McDowell, Robert Maurice Pitti, Sarah Catherine Bodary
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Patent number: 6387849Abstract: Novel hydroximic acid derivatives I and salts thereof, where X=O, S; Y=O, S; R1=H, C1-C4-alkyl, NH2, C1-C4-alkylamino or di(C1-C4-alkyl)amino; R2=C1-C3-haloalkyl; R3=H, halogen, C1-C4-alkyl; R4=H, halogen; R5=CN, halogen; R6=C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl or phenyl-C1-C6-alkyl, where the phenyl ring of this group may be unsubstituted or may carry 1-3 substituents; R7=a C1-C6-alkyl, C2-C6-alkenyl, C3-C6-alkynyl or phenyl-C1-C6-alkyl, where these 4 groups may be unsubstituted or may carry 1 to 2 substituents; Use: As herbicides; for the desiccation/defoliation of plants.Type: GrantFiled: September 21, 1999Date of Patent: May 14, 2002Assignee: BASF AktiengesellschaftInventors: Olaf Menke, Gerhard Hamprecht, Markus Menges, Robert Reinhard, Peter Schäfer, Cyrill Zagar, Karl-Otto Westphalen, Ulf Misslitz, Helmut Walter
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Patent number: 6380387Abstract: Compounds of Formula I are disclosed, having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.Type: GrantFiled: November 21, 2000Date of Patent: April 30, 2002Assignee: Hoffmann-La Roche Inc.Inventors: Achyutharao Sidduri, Jefferson Wright Tilley
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Patent number: 6376426Abstract: The invention relates to novel 3-heterocycl-1-yluracils of formula I: wherein R1 and R2 together with the interjacent nitrogen atom form an optionally substituted, optionally benzo-condensed 5-membered heterocyclic ring and R3 through R5 have the meaning given in claim 1. The invention also relates to a method of the production of these substances and to herbicidal compositions containing such compounds as active ingredients.Type: GrantFiled: January 31, 2000Date of Patent: April 23, 2002Assignee: BASF AktiengesellschaftInventors: Stefan Scheiblich, Trevor Newton, Peter Johannes Servaas Savio van Eijk, Isabel Waldeck
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Publication number: 20020045753Abstract: A compound of the formula 1Type: ApplicationFiled: September 4, 2001Publication date: April 18, 2002Applicant: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)Inventors: Pierre Etienne Chabrier de Lassauniere, Serge Auvin, Dennis Bigg, Michel Auguet, Jeremiah Harnett
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Patent number: 6372751Abstract: This invention is directed to aryl and heterocyclyl substituted pyrimidine derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants.Type: GrantFiled: March 30, 2000Date of Patent: April 16, 2002Assignee: Berlex Laboratories, Inc.Inventors: David D. Davey, Gary B. Phillips
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Patent number: 6372691Abstract: The present invention relates to a method for controlling weeds in corn field which comprises applying a herbicidal composition comprising 2-[2-chloro-4-fluoro-5-{3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl}phenoxy]propionic acid ester as an active ingredient to corn fields after seeding corn. According to the present method, kinds of weeds in corn fields can be controlled widely and no problematic phytotoxicity to corn is caused.Type: GrantFiled: December 14, 2000Date of Patent: April 16, 2002Assignee: Sumitomo Chemical Company, LimitedInventor: Nobuaki Mito
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Patent number: 6369002Abstract: Compounds of formula 1 wherein R1 is hydrogen, fluorine, chlorine, bromine or methyl; R2 is C1-C4alkyl, C1-C4halogenalkyl, halogen, hydroxy, C1-C4alkoxy, C1-C4halogenalkoxy, nitro, amino or cyano; R3, R15 to R39 and X6 to X19 are as defined in claim 1, and the agrochemically acceptable salts and stereoisomers of these compounds of formula I are suitable for use as herbicides.Type: GrantFiled: October 30, 2000Date of Patent: April 9, 2002Assignee: Syngenta Crop Properties, Inc.Inventors: Walter Kunz, Kurt Nebel
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Patent number: 6362337Abstract: The invention relates to substituted phenyluracils of the general formula (I) in which the radicals R1 to R5, Q and n are each as defined in the description, and to processes for their preparation and to their use as herbicides.Type: GrantFiled: June 22, 2001Date of Patent: March 26, 2002Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Otto Schallner, Katharina Voigt, Markus Dollinger, Hans-Joachim Santel
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Publication number: 20020035272Abstract: This invention provides compounds of Formula I having the structure 1Type: ApplicationFiled: April 23, 2001Publication date: March 21, 2002Applicant: American Home Products CorporationInventors: Paul J. Dollings, Robert E. McDevitt, Folake O. Adebayo
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Patent number: 6355796Abstract: An improved process and intermediate compounds for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-one compounds having the structural formula I and an improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having the structural formula VType: GrantFiled: February 3, 2000Date of Patent: March 12, 2002Assignee: BASF AktiengesellschaftInventor: Venkataraman Kameswaran
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Publication number: 20020026053Abstract: The present invention relates to novel 3-(substituted)-2-indolinones compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related disorders such as cancer.Type: ApplicationFiled: July 30, 2001Publication date: February 28, 2002Inventors: Peng Cho Tang, Li Sun, Gerald McMahon
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Patent number: 6350873Abstract: The present invention relates to a process for preparing 5′-acetylstavudine, an intermediate which is useful in the preparation of 2′,3′-didehydro-3′-deoxythymidine, an active principle with antiviral action which is commonly known as stavudine (D4T).Type: GrantFiled: April 12, 2001Date of Patent: February 26, 2002Assignee: Clariant Life Science Molecules (Italy) S.p.A.Inventors: Giorgio Bertolini, Marco Frigerio, Maurizio Velati, Luigi Petrucciani
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Patent number: RE37729Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: February 3, 1999Date of Patent: June 4, 2002Assignee: Aventis Pharmaceuticals Inc.Inventors: Edward J. Glamkowski, Yulin Chiang, Joseph T. Strupczewski, Kenneth J. Bordeau, Peter A. Nemoto, John J. Tegeler
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Patent number: RE37979Abstract: The disclosure concerns pyrimidine derivatives represented by the following general formulas [I] and [I′] and having antiviral activity, particularly antiretroviral activity such as anti-HIV activity: and pharmaceutical compositions having antiviral activity and comprising the above-described derivative(s) as an active ingredient.Type: GrantFiled: October 23, 1997Date of Patent: February 4, 2003Assignee: Mitsubishi Chemical CorporationInventors: Tadashi Miyasaka, Hiromichi Tanaka, Erik Desiré DeClercq, Masanori Baba, Richard Thomas Walker, Masaru Ubasawa