Chalcogen Or -c(=x)-, Wherein X Is Chalcogen, Attached Directly To The Six Membered Hetero Ring By Nonionic Bonding Patents (Class 546/110)
  • Patent number: 4874803
    Abstract: The present invention comprises reaction products resulting from the reaction of hydrazido-substituted or certain amino-substituted polymer stabilizers and cyclic dianhydrides, as well as the use of such products. The polymer stabilizers of the invention are useful for protecting a large variety of synthetic polymeric organic materials from the degradative effects of heat, light and oxygen. Some of the modifiers are flame retardants and many are metal deactivators in addition to their primary activity.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: October 17, 1989
    Assignee: Pennwalt Corporation
    Inventors: Arthur L. Baron, Terry N. Myers, Jerome Wicher
  • Patent number: 4761403
    Abstract: Hydroxy quinol-1-one and quinol-2-one based compounds found to be potent inhibitors of 5-, 12-, and 15-lipoxygenase enzymes.
    Type: Grant
    Filed: April 9, 1986
    Date of Patent: August 2, 1988
    Assignee: Abbott Laboratories
    Inventors: Bruce P. Gunn, James B. Summers, Jr.
  • Patent number: 4751309
    Abstract: Methine dyes (I) which conform in one of their tautomeric forms to the general formula ##STR1## where Y.sup.1 is in both or either case an electron-attracting group and the other Y.sup.1 is hydrogen,Y.sup.2 is in each case, independently of the others, hydrogen, --CN, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, phenyl, pyridyl or together with a further Y.sup.2 a five- or six-membered ring which may have a fused-on benzene ring,R is hydrogen, C.sub.1 -C.sub.20 -alkyl, C.sub.7 -C.sub.10 -aralkyl or .beta.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: June 14, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Ewald Daltrozzo, Werner Sulger
  • Patent number: 4727149
    Abstract: Nitriles of fused ring pyridine compounds such as 5,6,7,8-tetrahydroquinolines are prepared from metal derivatives of the starting compounds such as 8-litho-5,6,7,8-tetrahydroquinolines which have been prepared by treating a 5,6,7,8-tetrahydroquinoline with a metal amide prepared in situ from a metal alkyl and an N-benzylidine-N-alkylamine.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: February 23, 1988
    Assignee: John Wyeth & Brother Limited
    Inventor: Robin G. Shepherd
  • Patent number: 4707552
    Abstract: Nitriles and thioamides of fused ring pyridine compounds such as 5,6,7,8-tetrahydroquinolines are prepared from metal derivatives of the starting compounds such as 8-lithio-5,6,7,8-tetrahydroquinolines which have been prepared by treating a 5,6,7,8-tetrahydroquinoline with a metal amide prepared in situ from a metal alkyl and an N-benzylidine-N-alkylamine.
    Type: Grant
    Filed: September 18, 1985
    Date of Patent: November 17, 1987
    Assignee: John Wyeth & Brother Limited
    Inventor: Robin G. Shepherd
  • Patent number: 4599409
    Abstract: The present invention relates to new bisamidine derivatives of polycyclic compounds such as 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrene-6(5H)-phenanthridone and 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrenephenanthridine and to a process for their preparation. The polycyclic bisamidines according to the invention are distinguished by valuable chemotherapeutic properties, such as, for example, an action against amoebas and trichomonads.
    Type: Grant
    Filed: February 15, 1984
    Date of Patent: July 8, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Balbir S. Bajwa, deceased, Dipak K. Chatterjee, Bimal N. Ganguli, Jurgen Reden, Noel J. de Souza
  • Patent number: 4511569
    Abstract: Disclosed are 5,6-dihydro benzo[f]quinolines and derivatives which are effective in increasing cardiac contractility. These compounds are useful in the treatment of congestive heart failure.
    Type: Grant
    Filed: August 26, 1982
    Date of Patent: April 16, 1985
    Assignee: Schering Corporation
    Inventors: Elizabeth M. Smith, Ronald J. Doll, Bernard R. Neustadt
  • Patent number: 4456606
    Abstract: 1,2-dihydron-7-oxo-3H,5H-naphtho[1,2,3-ij]quinolizine-6-carboxylic acids are disclosed as active antimicrobial agents as are pharmaceutically acceptable esters, amides, acyl halides and salt derivatives thereof. Intermediates and synthetic processes are also disclosed.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: June 26, 1984
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster
  • Patent number: 4328230
    Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain--COCH.dbd.C(COOH)NRh--,or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: May 4, 1982
    Assignee: Fisons Limited
    Inventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
  • Patent number: 4291042
    Abstract: Compounds of formula: ##STR1## and pharmaceutically acceptable acid addition or quaternary ammonium salts thereof wherein the piperidine ring is substituted in the 3 or 4 position; X represents .dbd.CH-- or .dbd.N--; Y represents --NR.sup.5 --, --O-- or --S-- wherein R.sup.5 is hydrogen or lower alkyl; A is lower alkylene or hydroxy lower alkylene, Z and Z.sup.1 independently represent ##STR2## Z may also represent --CH.sub.2 --, --(CH.sub.2).sub.2 --, --CHMe-- or --CMe.sub.2 --; R.sup.1, R.sup.2, R.sup.3 independently represent hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino, trifluoromethyl, lower-alkanoylamino, hydroxy or aryl lower alkoxy; or R.sup.1 and R.sup.2 when adjacent together with the carbons to which they are attached form a six membered carbocyclic ring; and R.sup.4 represents hydrogen or lower alkyl, are disclosed which possess psychotropic activity and are useful as anti-depressants.
    Type: Grant
    Filed: January 21, 1980
    Date of Patent: September 22, 1981
    Assignee: John Wyeth & Brother Limited
    Inventor: Terence J. Ward
  • Patent number: 4260764
    Abstract: 1,9-Dihydroxyoctahydrobenzo[c]quinolines (I), 1-hydroxyhexahydrobenzo[c]quinoline-9(8H)-ones (II), and 1-hydroxy-tetrahydrobenzo[c]quinolines (IV) useful as CNS agents, especially as analgesics and tranquilizers, as hypotensives, as agents for the treatment of glaucoma and as diuretics; intermediates therefor (III) and derivatives thereof having the formulae ##STR1## wherein R is hydroxy, alkanoyloxy having from one to five carbon atoms and hydroxymethyl;R.sub.1 is hydrogen, benzyl, benzoyl, alkanoyl having from one to five carbon atoms or --CO--(CH.sub.2).sub.p --NR.sub.2 R.sub.3 wherein p is 0 or an integer from 1 to 4; each of R.sub.2 and R.sub.3 when taken individually is hydrogen or alkyl having from one to four carbon atoms; R.sub.2 and R.sub.3 when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring (piperidino, pyrrolo, pyrrolidino, morpholino and N-alkylpiperazino having from one to four carbon atoms in the alkyl group); R.sub.
    Type: Grant
    Filed: May 29, 1979
    Date of Patent: April 7, 1981
    Assignee: Pfizer Inc.
    Inventor: Michael R. Johnson
  • Patent number: 4247699
    Abstract: The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxy-quinolines and 2-amino-.alpha.,.alpha.-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxy-quinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxy-pyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.
    Type: Grant
    Filed: March 14, 1979
    Date of Patent: January 27, 1981
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin
  • Patent number: 4229455
    Abstract: Benzocycloheptapyridines with an imine bridge in the cycloheptane ring, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease.
    Type: Grant
    Filed: October 18, 1978
    Date of Patent: October 21, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, Wasyl Halczenko
  • Patent number: 4224448
    Abstract: 2- and 4- (5'nitrofuryl) quinoline derivatives which may be variously substituted on the quinoline nucleus have been found to possess excellent antibacterial and antifungal activity. Procedures for their manufacture are disclosed.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: September 23, 1980
    Inventors: Raphael R. G. Haber, Eva Schoenberger
  • Patent number: 4175193
    Abstract: The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxyquinolines and 2-amino-.alpha.,.alpha.-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxyquinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxypyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.
    Type: Grant
    Filed: March 27, 1978
    Date of Patent: November 20, 1979
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin
  • Patent number: 4169893
    Abstract: Anti-allergic 4-hydroxy-naphthpyridine-2(1H)-one-3-carboxylic acids and esters are prepared by reacting a 1,3-dioxo-1-naphth[4,5-b]oxazine with an alkali metal salt of a malonic ester (and hydrolyzing to obtain the acids).
    Type: Grant
    Filed: March 13, 1978
    Date of Patent: October 2, 1979
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Patent number: 4168311
    Abstract: Hydroxypyridine carbamates of the formula ##STR1## wherein R.sub.1 to R.sub.5 as defined below are valuable insecticides and particularly aphicides andCompounds of the formula ##STR2## wherein one of R'.sub.1 and/or R'.sub.3 are substituted carbamoyl and the other is preferably hydrogen or methyl, R'.sub.2 is a variety of substituents among which is hydrogen and acetyl, and R'.sub.3 and R'.sub.4 preferably form together a saturated or unsaturated C.sub.4 -chain which may be substituted, are valuable aphicides.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: September 18, 1979
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adolf Studeneer, Gerhard Salbeck, Ludwig Emmel, Werner Knauf
  • Patent number: 4156726
    Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
    Type: Grant
    Filed: November 26, 1975
    Date of Patent: May 29, 1979
    Assignee: Fisons Limited
    Inventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
  • Patent number: 4153601
    Abstract: A compound having the formula ##STR1## wherein A denotes an optionally substituted aromatic, isocyclic or heterocyclic residue; R is H, an alkyl residue having from 1 to 6 carbon atoms, an aryl residue having from 6 to 10 carbon atoms or an aralkyl residue having from 7 to 10 carbon atoms; Q is H or a methyl group; X and Y are the same or different and each is a non-water solubilizing group, or X and Y together form a fused aromatic ring system; and R.sub.1 and R.sub.2 are the same or different and each is H or an alkyl radical having from 1 to 22 carbon atoms, and R.sub.3 is hydrogen, an alkyl radical having from 1 to 22 carbon atoms or an aryl radical having from 6 to 10 carbon atoms, the alkyl radicals in R.sub.1, R.sub.2 and R.sub.3 being unsubstituted and uninterrupted or being substituted by an OH, NH.sub.2 or CN group and/or being interrupted by an ethylenic group or an oxygen, sulphur or nitrogen bridge, or two or all three of R.sub.1, R.sub.2 and R.sub.
    Type: Grant
    Filed: June 27, 1977
    Date of Patent: May 8, 1979
    Assignee: Ciba-Geigy Corporation
    Inventors: Terence R. Chamberlain, Colin D. Campbell, James M. McCrae