Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos Patents (Class 546/18)
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Patent number: 8623521Abstract: A heterocyclic compound, an organic light-emitting diode, and a flat display device, the heterocyclic compound being represented by Formula 1, below:Type: GrantFiled: December 6, 2011Date of Patent: January 7, 2014Assignee: Samsung Display Co., Ltd.Inventors: Young-Kook Kim, Seok-Hwan Hwang, Hye-Jin Jung, Jin-O Lim, Sang-Hyun Han, Yoon-Hyun Kwak, Sun-Young Lee, Hee-Joo Ko, Jong-Hyuk Lee, Sung-Chul Kim
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Publication number: 20130338134Abstract: The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer.Type: ApplicationFiled: June 12, 2013Publication date: December 19, 2013Inventors: Liangxing Wu, Colin Zhang, Chunhong He, Yaping Sun, Liang Lu, Ding-Quan Qian, Meizhong Xu, Jincong Zhuo, Wenqing Yao
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Patent number: 8597802Abstract: Disclosed are an acridine derivative and an organic electro-luminescence device including the same. Specifically, the disclosed acridine derivative compound has an aryl moiety or a heteroaryl moiety, linked to an acridine moiety and an amine moiety, and the disclosed organic electro-luminescence device including the acridine derivative compound requires a low operating voltage, shows high efficiency, and is enhanced in life-span.Type: GrantFiled: June 1, 2010Date of Patent: December 3, 2013Assignee: Doosan CorporationInventors: Tae-Hyung Kim, Kyoung-Soo Kim
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Publication number: 20130317010Abstract: To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT5A receptor regulating action, it was found that a tetrahydroisoquinoline derivative characterized by a structure in which an acylguanidino group binds to a N atom of a tetrahydroisoquinoline ring or the like, and a cyclic group binds to an unsaturated ring has a potent 5-HT5A receptor regulating action and an excellent pharmacological action based on the regulating action and also discovered that the tetrahydroisoquinoline derivative is useful as an agent for treating or preventing dementia, schizophrenia, and the like, whereby the present invention has been completed.Type: ApplicationFiled: August 1, 2013Publication date: November 28, 2013Applicant: Astellas Pharma IncInventors: Wataru HAMAGUCHI, Isao KINOYAMA, Yohei KOGANEMARU, Takehiro MIYAZAKI, Osamu KANEKO, Ryuichi SEKIOKA, Takuya WASHIO
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Patent number: 8586210Abstract: The present invention provides an organic compound having excellent properties, which is excellent in electron-injection/transport performance, has hole-blocking ability and is high stability in a thin-film state, as a material for an organic electroluminescence device having a high efficiency and a high durability, and provides is an organic electroluminescence device having a high efficiency and a high durability using the compound. The present invention relates to a compound having a substituted anthracene ring structure and a pyridoindole ring structure represented by general formula (1); and an organic electroluminescence device having a pair of electrodes and at least one organic layer interposed between the electrodes in which the at least one organic layer contains the compound.Type: GrantFiled: September 18, 2009Date of Patent: November 19, 2013Assignee: Hodogaya Chemical Co., Ltd.Inventors: Norimasa Yokoyama, Shuichi Hayashi, Sawa Izumi, Naoaki Kabasawa, Shigeru Kusano
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Publication number: 20130302282Abstract: A class of compounds that inhibit Hepatitis C Virus (HCV) is disclosed, along with compositions containing the compound, and methods of using the composition for treating individuals infected with HCV.Type: ApplicationFiled: October 21, 2011Publication date: November 14, 2013Applicant: Presidio Pharmaceuticals, Inc.Inventors: Min Zhong, Leping Li
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Patent number: 8580399Abstract: Novel compounds containing substituted oligoazacarbazole chains are provided. These compounds are useful in organic light emitting devices, in particular as hosts in the emissive layer of such devices.Type: GrantFiled: April 8, 2011Date of Patent: November 12, 2013Assignee: Universal Display CorporationInventors: Alexey Dyatkin, Lichang Zeng
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Patent number: 8580393Abstract: A polymer compound including a repeating unit shown by the following formula (1) wherein at least one of Ar1, Ar2 and Ar3 in the formula (1) is a group shown by the formula (2) and the two bonds shown in the formula (1) are present on any one or any two of Ar1, Ar2, Ar3 and L1.Type: GrantFiled: February 25, 2009Date of Patent: November 12, 2013Assignee: Idemitsu Kosan Co., Ltd.Inventors: Yumiko Mizuki, Nobuhiro Yabunouchi, Mitsuru Eida
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Patent number: 8580808Abstract: A compound, its pharmaceutically acceptable salt, a composition containing the same and method of treatment that can provide analgesia and/or reduce inflammation are disclosed. A contemplated compound has a structure that corresponds to Formula A, wherein G, W, Q, Z, D, E, F, K, Y, d, e, f, k, n, m, and circle B and all R groups are defined within.Type: GrantFiled: October 30, 2009Date of Patent: November 12, 2013Assignee: Pain Therapeutic, Inc.Inventors: Lindsay Burns Barbier, Hoau-Yan Wang, Nan-Horng Lin, Andrei Blasko
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Patent number: 8580396Abstract: The present invention relates to novel carbazole derivatives and an organic light-emitting diode device using the same. These carbazole derivatives can simultaneously or singly be used as a hole transporting layer, a host or guest of an emitting layer or an electron transporting layer of an organic light-emitting diode device.Type: GrantFiled: January 21, 2011Date of Patent: November 12, 2013Assignee: China Petrochemical Development CorpInventors: Hsiao Chan Liu, Min Sheng Chen, Chin Yi Lee
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Patent number: 8580402Abstract: A new class of dibenzothiophene and/or dibenzofuran-containing compounds are provided. The new compounds may be useful in organic light emitting devices, particularly as the host of an emissive layer having a host and an emissive dopant, or as a material in an enhancement layer.Type: GrantFiled: July 19, 2011Date of Patent: November 12, 2013Assignee: Universal Display CorporationInventors: Chun Lin, Alexey Borisovich Dyatkin, Zeinab Elshenawy, Walter Yeager
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Publication number: 20130296317Abstract: Disclosed are compounds of Formula (I): and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO2—, —O— or NRac—, wherein Rac is H, or C1-20 alkyl and R1 through R5 are defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.Type: ApplicationFiled: October 25, 2011Publication date: November 7, 2013Inventors: John A. McCauley, Hemaka A. Rajapakse, Thomas J. Greshock, John Sanders, Boyoung Kim, Vanessa L. Rada, Jonathan T. Kern, Heather H. Stevenson, Mark T. Bilodeau
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Patent number: 8563722Abstract: The present invention relates to a method comprising reducing a ketone of formula I: with an enantioselective hydrogenating agent to form substantially enantiomerically pure alcohol of formula II: where R—R4 and m are as defined herein. The method of the present invention is useful for making CCR2 modulators as wells as precursors CCR2 modulators.Type: GrantFiled: February 23, 2010Date of Patent: October 22, 2013Assignee: Glaxo Group LimitedInventors: Pamela A. Haile, Clark A. Sehon, Huan Wang
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Publication number: 20130274474Abstract: This invention relates to 1,3-oxathiolane derivatives (I), processes for the preparation of 1,3-oxathiolane derivatives and intermediate compounds thereof.Type: ApplicationFiled: April 12, 2013Publication date: October 17, 2013Applicant: APOTEX PHARMACHEM INC.Inventors: Craig Stewart, Michael B. Johansen, Probal Kanti Datta, Yajun Zhao
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Publication number: 20130267710Abstract: This invention provides novel (1R,4R) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof, preferably in substantially enantiomerically enriched forms, intermediates thereto, and processes of their synthesis.Type: ApplicationFiled: January 24, 2013Publication date: October 10, 2013Inventor: Robert M. Moriarty
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Patent number: 8552181Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimer's disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula I or Formula II wherein R1a-1c, B, R3-5 and W of Formula I, and R1a-1c, R2-5, A1-4, W, X, Z, m and n of Formula II are defined herein. The invention further provides compounds of Formula III and IV and sub-Formulas II-A-II-D and III-A-III-D. The compounds may be used in pharmaceutical compositions for treating, prophylactically or therapeutically, disorders related to the activity of beta-secretase protein, including without limitation, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.Type: GrantFiled: March 1, 2012Date of Patent: October 8, 2013Assignee: Amgen Inc.Inventors: Wenge Zhong, Stephen Hitchcock, Vinod F. Patel, Michael Croghan, Thomas Dineen, Scott Harried, Daniel Horne, Ted Judd, Matthew Walker, Charles Kreiman, Patricia Lopez, Holger Monenschein, Thomas Nguyen, Matthew Weiss, Qiufen Xue, Bryant Yang, Russell Graceffa
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Patent number: 8545885Abstract: The subject invention provides a pharmaceutical composition comprising N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide or the salt thereof; a pharmaceutically acceptable carrier; and not more than 0.5% w/w relative to N-ethyl-N-phenyl-1,2,-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide of 2-Chloro-6-(1-ethyl-N-methyl-2-oxoindoline-3-carboxamido)benzoic acid, 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3?-[1]ethylindolin-[2]-one], or 5-Chloro-N-ethyl-3-hydroxy-1-methyl-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydro-quinoline-3-carboxamide.Type: GrantFiled: May 14, 2012Date of Patent: October 1, 2013Assignees: Teva Pharmaceutical Industries, Ltd., Active Biotech, ABInventors: Muhammad Safadi, Daniella Licht, Ioana Lovinger, Aharon M. Eyal, Tomas Fristedt, Karl Jansson
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Publication number: 20130252993Abstract: The present invention relates to the compound represented by formula (I): (wherein, all the symbols have the same meaning as that of the specification), a salt thereof, a solvate thereof or a prodrug thereof. Since the compound of the present invention has an anti stress action, it is useful for preventive and/or therapeutic agent for a disease caused by stress, especially a digestive system disease caused by stress and is superior to oral absorption.Type: ApplicationFiled: May 17, 2013Publication date: September 26, 2013Applicant: ONO PHARMACEUTICAL CO., LTD.Inventors: Kazuyuki OHMOTO, Masashi KATO, Yoshifumi KAGAMIISHI, Junichiro MANAKO
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Publication number: 20130251647Abstract: The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.Type: ApplicationFiled: September 20, 2012Publication date: September 26, 2013Applicant: BASF SEInventors: Thomas Subkowski, Claus Bollschweiler, Jens Wittenberg, Wolfgang Siegel, Ralf Pelzer
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Publication number: 20130245009Abstract: The present invention relates to new CGRP-antagonists of general formulae Ia and Ib wherein R1, R2, R3, R4 and R5 are defined as mentioned below, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, the mixtures and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.Type: ApplicationFiled: April 24, 2013Publication date: September 19, 2013Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Dirk GOTTSCHLING, Georg DAHMANN, Henri DOODS, Annekatrin HEIMANN, Stephan Georg MUELLER, Klaus RUDOLF, Gerhard Georg SCHAENZLE, Dirk STENKAMP
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Publication number: 20130237707Abstract: Pharmaceutical-grade compounds containing cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine having a purity >99.0% by HPLC with less than 0.5% of trans-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine are provided.Type: ApplicationFiled: April 30, 2013Publication date: September 12, 2013Applicant: Apicore, LLCInventors: Ravishanker Kovi, Jayaraman Kannapan, Talluri Buhshaiah Chowdari, Chirag Vasantlal Shah
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Publication number: 20130231327Abstract: Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.Type: ApplicationFiled: April 15, 2013Publication date: September 5, 2013Applicant: Gruenenthal GmbHInventor: Gruenenthal GmbH
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Patent number: 8518911Abstract: The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.Type: GrantFiled: July 27, 2009Date of Patent: August 27, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: Jason D. Katz, Sandra L. Knowles, James P. Jewell, David L. Sloman, Matthew G. Stanton, Njamkou Noucti
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Patent number: 8513417Abstract: The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with 15N. The above-described problem can be solved by reacting a triacetoneamine derivative with ketone or aldehyde in the presence of ammonium salt or a 15N-labeled compound thereof to obtain a 2,6-substituted-4-piperidone derivative.Type: GrantFiled: January 30, 2008Date of Patent: August 20, 2013Assignee: Kyushu University, National University CorporationInventors: Hideo Utsumi, Kiyoshi Sakai, Kenichi Yamada
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Patent number: 8512877Abstract: Naphthylcarbazole derivatives are provided. The naphthylcarbazole derivatives are represented by Formula 1. Further provided are KL host materials, organic electroluminescent devices employing the host materials, and displays and lighting systems comprising the devices.Type: GrantFiled: March 27, 2008Date of Patent: August 20, 2013Assignee: Dongwoo Fine-ChemInventors: Kyong Min Kang, Deug Sang Lee, Chang Jun Lee, Kyoung Moon Go, Jong Soon Lee, Se Hoon Kim
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Patent number: 8507516Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic ?7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.Type: GrantFiled: October 26, 2010Date of Patent: August 13, 2013Assignee: Bristol-Myers Squibb CompanyInventors: Ivar M. McDonald, Robert A. Mate, James H. Cook, II, Dalton King, Richard E. Olson, Nenghui Wang, Christiana I. Iwuagwu, F. Christopher Zusi, John E. Macor
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Patent number: 8507477Abstract: Compounds of Formula (I): (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.Type: GrantFiled: August 14, 2009Date of Patent: August 13, 2013Assignee: Merck, Sharp & Dohme, Corp.Inventors: Michael R. Wood, Ian M. Bell, June J. Kim, Harold G. Selnick, Craig A. Stump
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Publication number: 20130203746Abstract: This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.Type: ApplicationFiled: November 16, 2012Publication date: August 8, 2013Inventor: Medivation Technologies Inc.
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Publication number: 20130196998Abstract: The present invention relates to spiro-cyclic amine derivatives of the formula (I) wherein R1 is selected from cyano, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkyl each optionally substituted with CN or one or more fluoro atoms, (3-6C)cycloalkyl, (4-6C)cycloalkenyl or a (8-10C)bicyclic group, each optionally substituted with halogen or (1-4C)alkyl, phenyl, biphenyl, naphthyl, each optionally substituted with one or more substituents independently selected from halogen, cyano, (1-6C)alkyl optionally substituted with one or more fluoro atoms, (1-6C)alkoxy optionally substituted with one or more fluoro atoms, amino, di(1-4C)alkylamino and (3-6C)cycloalkyl optionally substituted with phenyl which may be substituted with (1-4C)alkyl or halogen, phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocycle, each optionally substituted with (1-4C)alkyl optionally substituted with one or more fluoro atoms, monocyclic heterocycle optionally independently substituted with halogen, (1-6C)aType: ApplicationFiled: July 8, 2011Publication date: August 1, 2013Applicant: AbbVie B.V.Inventors: Axel Stoit, Wouter I. Iwema Bakker, Hein K.A.C. Coolen, Maria J.P. van Dongen, Nicolas J.-L.D. Leflemme
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Publication number: 20130193382Abstract: The present invention relates to compounds of the formula (I) and to the use thereof in electronic devices. The invention furthermore relates to electronic devices, preferably organic electroluminescent devices (OLEDs), comprising one or more com-pounds of the formula (I). The invention again furthermore relates to the preparation of compounds of the formula (I) and to formulations comprising one or more compounds of the formula (I).Type: ApplicationFiled: September 6, 2011Publication date: August 1, 2013Applicant: MERCK PATENT GmbHInventors: Arne Buesing, Thomas Eberle, Irina Martynova, Teresa Mujica-Fernaud
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Patent number: 8492398Abstract: The present invention relates to spiroazaindole compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.Type: GrantFiled: April 28, 2009Date of Patent: July 23, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: Joan M. Pierce (nee Fletcher), Jeffrey J. Hale, Shouwu Miao, Petr Vachal
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Publication number: 20130172379Abstract: A method administers quaternary ammonium anti-cholinergic muscarinic receptor antagonists in combination with acetyl-cholinesterase inhibitors to treat either cognitive impairment or acute delirium. This therapy results in a modification of a cognitive disorder or disease, namely a slow down in the disease progression. In one preferred embodiment, the disease is dementia with Lewy Bodies. New formulations for quaternary ammonium anti-cholinergic muscarinic receptor antagonists are also disclosed.Type: ApplicationFiled: February 27, 2013Publication date: July 4, 2013Inventor: Steven A. Rich
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Publication number: 20130172343Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I: (I). In another embodiment, the compounds have a general Formula II: (II). In another embodiment, the compounds have a general Formula III: (III). Variables A1, A2, A3, A4, A5, A6, R2, R7, V, W, X, Y and Z of Formulas I, II and III are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain.Type: ApplicationFiled: August 4, 2011Publication date: July 4, 2013Applicant: Amgen Inc.Inventors: Ana Elena Minatti, Yuan Cheng, Wenge Zhong
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Patent number: 8475935Abstract: Novel anthracene derivatives, novel materials capable of blue light emission with high color purity, and a light-emitting element, a light-emitting device, and an electronic device using any of the novel materials. The anthracene derivative represented by general formula (1) is provided. With the anthracene derivative, a light-emitting element with high emission efficiency can be provided. With the anthracene derivative, a light-emitting element emitting blue light with high color purity can be provided. In the formula, A1 represents a substituted or unsubstituted phenyl group, B1 represents any of an alkyl group having 1 to 4 carbon atoms or a substituted or unsubstituted phenyl group, ? represents any of a substituted or unsubstituted phenylene group or a substituted or unsubstituted biphenyl-4,4?-diyl group, and R1 to R9 individually represent any of hydrogen, an alkyl group having 1 to 4 carbon atoms, or a substituted or unsubstituted phenyl group.Type: GrantFiled: December 16, 2008Date of Patent: July 2, 2013Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Harue Osaka, Sachiko Kawakami, Nobuharu Ohsawa, Satoshi Seo
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Patent number: 8475939Abstract: An m-terphenyl derivative has a structure of formula (I) or (II): wherein A and B are five-membered heterocyclic compounds selected from the group consisting of pyrrole, pyrazole, imidazole, 1,2,3-triazole, 1,2,4-triazole, 1,2,3,4-tetrazole, 1,2-thiazole, 1,3-thiazole and 1,3,4-thiadiazole, each of substituents R, R1 and R2 is a member independently selected from the group consisting of H, halo, cyano, trifluoromethyl, amino, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl and heteroaryl. The compound of the present invention may have advantages in good electron affinity, low HOMO and thereby achieving hole blocking and may be used for electron transport material and/or electron injection material.Type: GrantFiled: January 6, 2011Date of Patent: July 2, 2013Assignee: National Tsing Hua UniversityInventors: Chien-Hong Cheng, Cheng-An Wu, Fang-Iy Wu, Cheng-Hung Shih
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Patent number: 8476293Abstract: The present invention relates to the compound represented by formula (I): (wherein, all the symbols have the same meaning as that of the specification), a salt thereof, a solvate thereof or a prodrug thereof. Since the compound of the present invention has an anti stress action, it is useful for preventive and/or therapeutic agent for a disease caused by stress, especially a digestive system disease caused by stress and is superior to oral absorption.Type: GrantFiled: April 29, 2011Date of Patent: July 2, 2013Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Kazuyuki Ohmoto, Masashi Kato, Yoshifumi Kagamiishi, Junichiro Manako
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Patent number: 8466288Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.Type: GrantFiled: January 13, 2012Date of Patent: June 18, 2013Assignee: Vertex Pharmaceuticals IncorporatedInventors: Alex Aronov, Jon H. Come, Robert J. Davies, Albert Charles Pierce, Philip N. Collier, Ronald Lee Grey, Jr., Hardwin O'Dowd, James A. Henderson, Elaine B. Krueger, Arnaud Le Tiran, Yusheng Liao, David Messersmith, Jian Wang, Suganthini S. Nanthakumar, Jingrong Cao, Upul Keerthi Bandarage, Anne-Laure Grillot
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Patent number: 8465849Abstract: This invention relates to deuterated electron transfer compounds useful in electronic applications. It also relates to electronic devices in which the electron transfer layer includes zirconium compounds with at least one of the aryl compounds containing some deuteration.Type: GrantFiled: December 21, 2009Date of Patent: June 18, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Adam Fennimore, Weiying Gao
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Patent number: 8450487Abstract: Methods are provided for making pharmaceutical-grade cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine and pharmaceutically acceptable salts thereof by isomerizing racemic 2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine to cis-2-methylspiro(1,3-oxathiolane-5,3?)quinuclidine and subsequent purification of the C-MSOQ by salt formation with inexpensive and commercially available material such as sulfuric acid. Purification methods are disclosed which employ an organic solvent/water system and recrystallization with an organic solvent such as acetone.Type: GrantFiled: June 8, 2010Date of Patent: May 28, 2013Assignee: Apicore, LLCInventors: Ravishanker Kovi, Jayaraman Kannapan, Talluri Buhshaiah Chowdari, Chirag Vasantlal Shah
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Patent number: 8431251Abstract: A heterocyclic compound represented by Formula 1 below and an organic light-emitting device including an organic layer that includes the following heterocyclic compound: wherein R1 to R13 are each independently a hydrogen atom, a heavy hydrogen atom, a substituted or unsubstituted C1-C60 alkyl group, a substituted or unsubstituted C2-C60 alkenyl group, a substituted or unsubstituted C2-C60 alkynyl group, a substituted or unsubstituted C3-C60 cycloalkyl group, a substituted or unsubstituted C1-C60 alkoxy group, a substituted or unsubstituted C5-C60 aryloxy group, a substituted or unsubstituted C5-C60 arylthio group, a substituted or unsubstituted C5-C60 aryl group, an amino group substituted with a C5-C60 aryl group or a C3-C60 heteroaryl group, a substituted or unsubstituted C3-C60 heteroaryl group, a substituted or unsubstituted C6-C60 condensed polycyclic group, a halogen atom, a cyano group, a nitro group, a hydroxy group, or a carboxy group.Type: GrantFiled: December 8, 2011Date of Patent: April 30, 2013Assignee: Samsung Display Co., Ltd.Inventors: Jin-O Lim, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Sang-Hyun Han, Chang-Ho Lee, Jong-Hyuk Lee, Hee-Joo Ko
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Patent number: 8431590Abstract: The present invention relates to a compound of the following formula: where R1-R6, R10, Y, n, m, p, and q are as defined herein. Compounds and compositions of the present invention are useful for the treatment of diseases associated with the overexpression of CCR2.Type: GrantFiled: June 20, 2008Date of Patent: April 30, 2013Assignee: Glaxo Group LimitedInventors: Brian W. Budzik, Hilary Schenck Eidam, Ryan Michael Fox, Krista B. Goodman, Dimitar B. Gotchev, Pamela A. Haile, Terry Vincent Hughes, Ronggang Liu, Nathan A. Miller, Tamara Ann Miskowski, Clark A. Sehon, Andrew Q. Viet, Gren Z. Wang, Jing Zhang
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Publication number: 20130096120Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.Type: ApplicationFiled: October 11, 2012Publication date: April 18, 2013Applicant: AbbVie Inc.Inventor: AbbVie Inc.
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Patent number: 8420230Abstract: Provided is an organic light emitting diode employing a luminescent efficiency improvement layer containing a compound represented by Formula 1 below: The OLED including the luminescent efficiency improvement layer containing the compound represented by Formula 1 can have excellent luminescent efficiency.Type: GrantFiled: August 14, 2009Date of Patent: April 16, 2013Assignee: Samsung Display Co., Ltd.Inventors: Seung-Gak Yang, Hee-Yeon Kim, Jae-Yong Lee, Jong-Hyuk Lee
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Patent number: 8409729Abstract: Novel aryl silicon and aryl germanium host materials are described. These compounds improve OLED device performance when used as hosts in the emissive layer of the OLED.Type: GrantFiled: July 28, 2011Date of Patent: April 2, 2013Assignee: Universal Display CorporationInventors: Lichang Zeng, Alexey B. Dyatkin, Gregg Kottas, Chuanjun Xia, David Z. Li
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Patent number: 8399109Abstract: Organic electronic devices comprising a phthalimide compound. The phthalimide compounds disclosed herein are electron transporters with large HOMO-LUMO gaps, high triplet energies, large reduction potentials, and/or thermal and chemical stability. As such, these phthalimide compounds are suitable for use in any of various organic electronic devices, such as OLEDs and solar cells. In an OLED, the phthalimide compounds may serve various functions, such as a host in the emissive layer, as a hole blocking material, or as an electron transport material. In a solar cell, the phthalimide compounds may serve various functions, such as an exciton blocking material. Various examples of phthalimide compounds which may be suitable for use in the present invention are disclosed.Type: GrantFiled: September 21, 2012Date of Patent: March 19, 2013Assignee: The University of Southern CaliforniaInventors: Azad M. Hassan, Mark E. Thompson
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Patent number: 8399503Abstract: The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.Type: GrantFiled: January 15, 2009Date of Patent: March 19, 2013Assignee: Gruenenthal GmbHInventors: Saskia Zemolka, Stefan Schunk, Ellen Bergrath, Babette-Yvonne Kögel, Werner Englberger, Klaus Linz, Hans Schick
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Patent number: 8399453Abstract: The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example. Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.Type: GrantFiled: July 19, 2011Date of Patent: March 19, 2013Assignee: Novartis AGInventors: Shi Hua Ang, Philipp Krastel, Seh Yong Leong, Liying Jocelyn Tan, Wei Lin Josephine Wong, Bryan K. S. Yeung, Bin Zou
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Publication number: 20130060036Abstract: Provided is a production method for a cis-QMF, which has a low environmental burden and is industrially advantageous. Specifically provided is a production method for a cis-type 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine hydrochloride, including: reacting a cis-trans isomer mixture of 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine with p-nitrobenzoic acid; resolving the resultant product to produce a cis-type 2-alkylspiro(1,3-oxathiolane-5,3?)quinuclidine p-nitrobenzoate; and converting the p-nitrobenzoate into a hydrochloride.Type: ApplicationFiled: October 21, 2010Publication date: March 7, 2013Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Yutaka Kitagawa, Masao Fujita, Kumiko Otaya
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Patent number: 8389131Abstract: Provided is an organic electroluminescent device (organic EL device), in which the luminous efficiency of the device is improved, driving stability is sufficiently ensured, and the construction of the device is simple. This organic EL device is an organic electroluminescent device, including a light-emitting layer between an anode and a cathode laminated on a substrate, in which the light-emitting layer contains a phosphorescent light-emitting dopant and an indolocarbazole compound as a host material. Examples of the indolocarbazole compound include a compound represented by the following formula (1).Type: GrantFiled: March 24, 2010Date of Patent: March 5, 2013Assignee: Nippon Steel Chemical Co., Ltd.Inventors: Takahiro Kai, Masaki Komori, Toshihiro Yamamoto, Megumi Matsumoto
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Patent number: 8383642Abstract: A compound of the formula: or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition, and a method for treating diabetes.Type: GrantFiled: October 11, 2010Date of Patent: February 26, 2013Assignee: Eli Lilly and CompanyInventors: Chafiq Hamdouchi, Jayana Pankaj Lineswala, Pranab Maiti