Chalcogen Bonded Directly To Ring Carbon Of The Six-membered Hetero Ring Patents (Class 546/24)
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Patent number: 4742060Abstract: Novel insecticides of the formula ##STR1## in which n is 0 or 1,X is S, O, ##STR2## Y is N or ##STR3## Z is a 5- or 6-membered nitrogen-containing heterocyclic ring, and R to R.sup.9 variously represent hydrogen or specified organic radicals.Type: GrantFiled: January 21, 1986Date of Patent: May 3, 1988Assignee: Nihon Tokushu Noyaku Seizo K. K.Inventors: Kozo Shiokawa, Shinichi Tsuboi, Shinzo Kagabu, Koichi Moriya
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Patent number: 4740235Abstract: There are described novel 3-fluoropyridyl-2-oxy derivatives having a herbicidal action and an action reducing the growth of grasses, which compounds correspond to the formula I ##STR1## wherein X is halogen or the trifluoromethyl group, andZ is an alkanoic acid derivative which is more precisely described in the specification.These compounds are suitable for the selective control of weeds in crops of cultivated plants, or for the reduction of the growth of grasses.Type: GrantFiled: March 26, 1986Date of Patent: April 26, 1988Assignee: Ciba-Geigy CorporationInventors: Rolf Schurter, Peter J. Diel
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Patent number: 4739079Abstract: Compounds having the formula ##STR1## wherein ##STR2## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.Type: GrantFiled: March 27, 1986Date of Patent: April 19, 1988Assignee: Pfizer Inc.Inventors: Michael R. Johnson, Lawrence S. Melvin, Jr.
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Patent number: 4716232Abstract: 1-(Vinyl phosphonate adduct) pyrazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds.Type: GrantFiled: May 14, 1986Date of Patent: December 29, 1987Assignee: Eli Lilly and CompanyInventor: Robert J. Ternansky
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Patent number: 4710579Abstract: A compound provided by the present invention, of the formula ##STR1## wherein R.sup.1 is C.sub.14-20 alkyl; R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1-5 alkyl, or ##STR2## represents a cyclic ammonio group; and A is C.sub.2-5 alkylene, and a pharmaceutically acceptable salt thereof, are useful as a anti-tumor agent.Type: GrantFiled: October 30, 1985Date of Patent: December 1, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Shoshichi Nojima, Hiroaki Nomura, Tetsuya Okutani
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Patent number: 4690708Abstract: A herbicide of the formula: ##STR1## in which: Z is N or CX',W, Y, Y', X, Z' and X' represent H, a halogen atom, NO.sub.2, CN or a polyhalogenoalkyl, alkyl or alkoxy group,R.sup.2 represents H, halogen, substituted alkyl, allyl, propargyl, CN, NR.sup.4 R.sup.5, C(X.sup.2)R.sup.7, C(X.sup.2)X.sup.3 R.sup.8, C(X.sup.2)NR.sup.4 R.sup.5, SO.sub.2 F, SO.sub.2 OR.sup.8, SO.sub.2 NR.sup.4 R.sup.5 or P(X.sup.2)R.sup.9 R.sup.10,R.sup.1 is halogen, X.sup.2 R.sup.3 or NR.sup.4 R.sup.5,R.sup.3 is optionally substituted alkyl or is allyl or propargyl,R.sup.4, R.sup.7 and R.sup.8 represent H, alkyl, cycloalkyl, phenyl, allyl, propargyl or the like,R.sup.5 represents R.sup.4, a cation or OR.sup.6, R.sup.6 being H, a cation or alkyl,X.sup.2 and X.sup.3 are O or S,R.sup.9 and R.sup.10 are H, alkyl, OH, OM or R.sup.1, andM is a cation.Type: GrantFiled: July 11, 1984Date of Patent: September 1, 1987Assignee: Rhone-Poulenc AgrochimieInventors: Alain Chene, Guy Borrod
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Patent number: 4685952Abstract: A benzoylaminoalkylphosphonic acid represented by the following formula (I) ##STR1## wherein X and Y are identical or different, and each represents a hydrogen atom, a halogen atom, CF.sub.3, or an alkyl group having not more than 5 carbon atoms, Z is CH or N, and R.sup.1, R.sup.2 and R.sup.3 are identical or different and each represents a hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms. The compound is useful, as a herbicide, for eradicating weeds, especially broad-leaved weeds.Type: GrantFiled: April 4, 1986Date of Patent: August 11, 1987Assignee: Teijin LimitedInventors: Shizuo Azuma, Toshiyuki Hiramatsu, Koji Nakagawa, Yataro Ichikawa
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Patent number: 4670040Abstract: Novel phenoxypropionyloxyalkanephosphonates of the formula ##STR1## in which R is optionally substituted alkyl andA is optionally substituted alkanediyl,and the use of such new compounds as herbicides.Type: GrantFiled: January 24, 1985Date of Patent: June 2, 1987Assignee: Bayer AktiengesellschaftInventors: Theodor Pfister, Heinz Forster, Ludwig Eue, Robert R. Schmidt, Hans-Joachim Santel
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Patent number: 4657577Abstract: Novel substituted pyridyl-phenyl ethers of the formula ##STR1## in which X represents trifluoromethyl or chlorine,Y represents hydrogen or chlorine,R.sup.1 represents hydrogen or methyl andR.sup.2 represents formyl or the radicals of the formulae ##STR2## in which R.sup.3 represents alkyl with 1 to 4 carbon atoms, or the two radicals R.sup.3 together represent an alkylene chain with 2 or 3 carbon atoms,R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of one another represent hydrogen or alkyl with 1 to 4 carbon atoms,m represents 1 or 2,n represents 0 or 1 andZ represents trimethylsilyl, optionally substituted azolyl which is bonded via nitrogen or the radicals of the formulae ##STR3## in which R.sup.8 represents alkyl with 1 to 4 carbon atoms,or the two radicals R.sup.8 together represent an alkylene chain with 2 or 3 carbon atoms,R.sup.9 represents alkyl with 1 to 4 carbon atoms,X.sup.1 represents oxygen or sulphur andR.sup.10 and R.sup.Type: GrantFiled: March 28, 1985Date of Patent: April 14, 1987Assignee: Bayer AktiengesellschaftInventors: Heinz Forster, Erich Klauke, Uwe Priesnitz, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt
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Patent number: 4655816Abstract: There are disclosed novel 2,6-substituted-3-pyridinecarboxylic acids, esters, and salts useful as herbicides, and as intermediates which provide herbicides.Type: GrantFiled: August 27, 1985Date of Patent: April 7, 1987Assignee: Monsanto CompanyInventors: Len F. Lee, Maria L. Miller
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Patent number: 4654072Abstract: Compounds having the formula ##STR1## in which R is hydrogen, cyano or --COOR.sub.2 ; R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; and Z is ##STR2## in which A is halogen, B is halogen or hydrogen and Y is nitrogen or --CH--, are herbicides.Type: GrantFiled: September 17, 1985Date of Patent: March 31, 1987Assignee: Stauffer Chemical CompanyInventor: Raymond A. Felix
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Patent number: 4632697Abstract: As new compounds, substituted aryloxyphenoxy benzamides having the formula ##STR1## in which X is nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, cyano or hydrogen; Z is hydrogen, chlorine, bromine, fluorine, iodine, CH.sub.n, F.sub.3-n where n is an integer from 0 to 3; R is nitro, hydrogen or halogen; R' is hydrogen, CH.sub.3, lower alkyl, having 1-10 carbon atoms, SCCl.sub.3, ##STR2## or --PO.sub.3 R.sup.3.sub.2 wherein R.sup.3 is hydrogen, alkyl having 1-10 carbon atoms, aryl, or an equivalent of base such as a salt; R" is cyano, --C.tbd.CH, ##STR3## wherein R.sup.4 is hydrogen, alkyl having 1-10 carbon atoms, aryl or an equivalent of base such as a salt; and m is 0, 1, 2 or 3.These compounds are useful as herbicides.Type: GrantFiled: February 25, 1985Date of Patent: December 30, 1986Assignee: Stauffer Chemical CompanyInventor: Sreeramulu Nagubandi
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Patent number: 4627870Abstract: Diphenyl ether derivatives of the formula ##STR1## and tautomers thereof wherein X is selected from the group consisting of chlorine, bromine, iodine, fluorine, methyl, cyano or hydrogen; Y is CF.sub.n H.sub.3-n or chlorine, wherein n is an integer from 0 to 3; R is selected from the group consisting of nitro, hydrogen or halogen; R" is hydrogen, alkyl, phenyl, or substituted alkyl wherein the alkyl group has from 1 to 10 carbon atoms; R"' is the same or different and is selected from C.sub.1 -C.sub.10 alkyl, phenyl or hydrogen; and agriculturally acceptable salts thereof. The compounds are effective as herbicides.Type: GrantFiled: February 25, 1985Date of Patent: December 9, 1986Assignee: Stauffer Chemical CompanyInventor: Sreeramulu Nagubandi
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Patent number: 4607031Abstract: An ethyl benzylphosphinate derivative represented by the general formula (I) ##STR1## wherein Y represents a hydrogen or fluorine atom, X represents a methylene group or an oxygen atom, and n is 2, 3 or 4.The said compounds can be produced by reacting a compound represented by the following formula (II) ##STR2## wherein Y is as defined above, with a compound represented by the following formula (III) ##STR3## wherein X and n are as defined, and M is an alkali metal atom, in an inert medium. These compounds are useful as a calcium antagonist.Type: GrantFiled: May 22, 1985Date of Patent: August 19, 1986Assignee: Kanebo Ltd.Inventors: Koichiro Yoshino, Tominori Morita, Masaru Moriyama, Keizo Ito, Goro Tsukamoto
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Patent number: 4605434Abstract: (2-Nitro-5-aryloxy-phenylamino)-alkylphosphine oxide derivatives of the formula I ##STR1## wherein X is halogen, CF.sub.3, NO.sub.2, CN, CONH.sub.2 or CSNH.sub.2,Y is nitrogen or --CH.dbd.,R.sup.1 is hydrogen, C.sub.1 -C.sub.4 -alkyl, or aralkyl having 1-4 carbon atoms in the alkyl moiety,R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, phenyl, benzyl or C.sub.1 -C.sub.4 -alkylbenzyl,R.sup.4 and R.sup.5 independently of one another are each C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.2 -C.sub.6 -alkoxyalkyl, or aralkyl having 1-4 carbon atoms in the alkyl moiety,m is zero to 3, andn is 1 to 3,have useful herbicidal properties.Type: GrantFiled: July 12, 1984Date of Patent: August 12, 1986Assignee: CIBA-GEIGY CorporationInventor: Ludwig Maier
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Patent number: 4605741Abstract: The present invention relates to a novel pharmacologically active salt derivative, constituted by 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy-phenyl)-1-butanone 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphate, to the process for the production thereof, and to the related pharmaceutical compositions.Said salt derivative is produced by reacting 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphoric acid with 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-3-butanone in an organic solvent and subsequently crystallizing the reaction product.Said salt derivative carries out an important pharmacological activity as inhibitor of platelet aggregation with vasodilative action.Type: GrantFiled: November 13, 1985Date of Patent: August 12, 1986Assignee: Lisapharma SpaInventors: Giorgio Zagnoli, Ubaldo Conte, Paolo Colombo
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Patent number: 4602946Abstract: As new compounds, substituted aryloxy benzoyl amino acid esters having the formula ##STR1## in which R is NO.sub.2, hydrogen or halogen; R' is H, lower alkyl having from about 1 to about 6 carbon atoms, PO.sub.3 R'2, SCC1.sub.3, or any combination thereof; R" is lower alkyl having from about 1 to about 8 carbon atoms, hydrogen, aryl, or a salt-forming cation selected from alkaline earth metals, magnesium, calcium, barium, iron, copper, zinc, and any other agriculturally acceptable salt; n is 1, 2, 3 or 4; W is oxygen, sulfur, or nitrogen; X is CH or nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, hydrogen or cyano; and Z is hydrogen, chlorine, bromine, iodine, fluorine, or CH.sub.m F.sub.3-m where m is the integer 0, 1, 2 or 3. These compounds are useful as herbicides.Type: GrantFiled: February 25, 1985Date of Patent: July 29, 1986Assignee: Stauffer Chemical CompanyInventor: Sreeramulu Nagubandi
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Patent number: 4598071Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.Type: GrantFiled: November 28, 1984Date of Patent: July 1, 1986Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4567167Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.Type: GrantFiled: November 28, 1984Date of Patent: January 28, 1986Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4560752Abstract: Novel 5-(substituted amino)phenoxyalkyl-, phenylthioalkyl-, phenylsulfinylalkyl-, and phenylsulfonylalkylphosphinates and phosphonates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.Type: GrantFiled: June 28, 1984Date of Patent: December 24, 1985Assignee: Zoecon CorporationInventor: Shy-Fuh Lee
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Patent number: 4548929Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.Type: GrantFiled: April 18, 1983Date of Patent: October 22, 1985Assignee: SDS Biotech CorporationInventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
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Patent number: 4546106Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.Type: GrantFiled: July 22, 1982Date of Patent: October 8, 1985Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
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Patent number: 4520197Abstract: Substituted tetrahydrobenzodiazaphosphorindiones or tetrahydropyridodiazaphosphorindiones, intermediates therefore, synthesis thereof, said compounds being useful herbicides.Type: GrantFiled: February 1, 1984Date of Patent: May 28, 1985Assignee: Zoecon CorporationInventor: Shy-Fuh Lee
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Patent number: 4470841Abstract: A herbicidal composition comprising as an active ingredient a compound of the formula: ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl group, a phenyl group or a C.sub.1 -C.sub.4 alkoxy group, R.sub.2 is a C.sub.1 -C.sub.4 alkyl group, R.sub.3 and R.sub.4, which are the same or different, are each a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or a phenyl group and R.sub.5 is a 2,4-dichlorophenyl group, a 4-trifluoromethylphenyl group or a 5-trifluoromethylpyridin-2-yl group, and an inert carrier.Type: GrantFiled: August 17, 1982Date of Patent: September 11, 1984Assignee: Sumitomo Chemical Company, LimitedInventors: Mitsuru Sasaki, Ryo Yoshida
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Patent number: 4469687Abstract: The invention relates to new chemical compounds corresponding to the following formula ##STR1## in which R is a non-hydrolyzable radical and Az represents aziridinyl ##STR2## These compounds may be used as medicaments.Type: GrantFiled: September 9, 1981Date of Patent: September 4, 1984Assignee: Agence Nationale de Valorisation de la RechercheInventors: Jean-Francois Labarre, Francois Sournies, Johan C. van de Grampel, Adriaan A. Van Der Huizen
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Patent number: 4456465Abstract: Novel phenoxyphenyl-substituted or pyridyloxyphenyl-substituted phosphinates and phosphinothioates, syntheses thereof, intermediates therefor, and the use of said novel phosphinates and phosphinothioates for the control of weeds.Type: GrantFiled: January 10, 1983Date of Patent: June 26, 1984Assignee: Zoecon CorporationInventor: Shy-Fuh Lee
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Patent number: 4433149Abstract: Substituted tetrahydrobenzodiazaphosphorindiones or tetrahydropyridodiazaphosphorindiones, intermediates therefore, synthesis thereof, said compounds being useful herbicides.Type: GrantFiled: May 19, 1982Date of Patent: February 21, 1984Assignee: Zoecon CorporationInventor: Shy-Fuh Lee
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Patent number: 4424359Abstract: Vinyl-substituted 2,2'-bipyridine compounds of the formula ##STR1## and complexes thereof with metals or metal compounds other than alkali metals or alkaline earth metals, or alkali metal compounds, or alkaline earth metal compounds are described, R.sub.1 and R.sub.2 being as defined in patent claim 1 and the vinyl group being bonded in the 4-position or 6-position. The 2,2'-bipyridine compounds (I) are suitable for the preparation of complex-forming or complexed, crosslinked or uncrosslinked polymers. Complexed polymers, obtainable from these, are used, for example, as catalysts, in particular for transvinylation reactions. Uncomplexed polymers, which can be prepared from compounds (I), are suitable as metal ion scavengers in various applications.Type: GrantFiled: July 27, 1981Date of Patent: January 3, 1984Assignee: Ciba-Geigy CorporationInventors: Ju/ rgen Kaschig, Dieter Lohmann
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Patent number: 4424213Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.Type: GrantFiled: November 2, 1981Date of Patent: January 3, 1984Assignee: SDS Biotech CorporationInventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
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Patent number: 4416831Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: November 1, 1982Date of Patent: November 22, 1983Assignee: E. R. Squibb & Sons, Inc.Inventor: Edward W. Petrillo, Jr.
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Patent number: 4374131Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: April 27, 1981Date of Patent: February 15, 1983Assignee: E. R. Squibb & Sons, Inc.Inventor: Edward W. Petrillo, Jr.
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Patent number: 4364767Abstract: There are provided N(carboxymethyl-N-(phosphonomethyl)-5-(2-chloro-4-trifluoromethyl phenoxy)-2-nitrobenzamide and salts thereof.Type: GrantFiled: July 27, 1981Date of Patent: December 21, 1982Assignee: Rhone-Poulenc AgrochimieInventor: Stanley T. D. Gough
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Patent number: 4355034Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.Type: GrantFiled: July 25, 1980Date of Patent: October 19, 1982Assignee: Merck & Co., Inc.Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
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Patent number: 4347194Abstract: Polyhydroxyl polyether compounds containing at least one monomeric unit each of the formulae: ##STR1## are disclosed. Polymeric condensation resins are prepared by allowing the polyhydroxyl polyethers to react with polyfunctional chain-forming compounds containing functional groups reactive with the hydroxyl groups of polyhydroxyl polyethers. The polyhydroxyl polyether compounds enhance the flame-retardant properties of polymeric condensation resins such as polyurethanes.Type: GrantFiled: May 11, 1981Date of Patent: August 31, 1982Assignee: The Dow Chemical Co.Inventors: Sally P. Ginter, Chester E. Pawloski, Violete L. Stevens
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Patent number: 4330536Abstract: Oxime phosphates of the formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 -alkyl,R.sub.2 is C.sub.1 -C.sub.7 -alkoxy or C.sub.1 -C.sub.6 -alkylthio,R.sub.3 is hydrogen, C.sub.1 -C.sub.6 -alkyl or cyano,A.sub.1, A.sub.2, A.sub.3 and A.sub.4 are each hydrogen or halogen,A.sub.5 is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.6 -alkyl, andX is oxygen or sulfur,a process for producing them, and their use for combating pests.Type: GrantFiled: February 23, 1981Date of Patent: May 18, 1982Assignee: Ciba-Geigy CorporationInventors: Georg Pissiotas, Ernst Beriger
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Patent number: 4327089Abstract: A novel O-(N-alkoxy-pyridinecarboximidoyl)-phosphate represented by the following formula: ##STR1## wherein X is a halogen atom, a lower alkyl group, a lower acyloxy group, a trifluoromethyl group or a nitro group; Y is an oxygen atom or a sulfur atom; R is a lower alkyl group; n is an integer of 0 to 3; and Z.sub.1 and Z.sub.2 are each a lower alkoxy group, a lower alkylthio group, a phenyl group which may be substituted by a lower alkyl group, a phenoxy group, a haloalkoxy group or a lower alkylamino group, useful as an active ingredient of insecticides or acaricides.Type: GrantFiled: December 12, 1980Date of Patent: April 27, 1982Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Tadaaki Toki, Toru Koyanagi, Osamu Imai
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Patent number: 4322531Abstract: The invention relates to diazaphospholanes and diazaphosphorinanes of the formula I ##STR1## in which m is 0 or 1, n is 1 or 2 and R.sup.1 to R.sup.4 are as defined in claim 1. These compounds are effective light stabilizers for organic materials, especially for polymers. In addition, they can also possess an antioxidant and/or a flame retardant action. They can be obtained from the corresponding diamines by a cyclization reaction with the phosphorus dichlorides R.sup.3 P(O).sub.m Cl.sub.2.Type: GrantFiled: September 18, 1980Date of Patent: March 30, 1982Assignee: Ciba-Geigy CorporationInventor: Friedrich Karrer
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Patent number: 4282213Abstract: Amidine phosphonates carrying an unsaturated nitrogen heterocycle-containing substituent, representative of which are N-methyl-N'-[2-(2-thiazolylmethylthio)ethyl]amidinophosphonic acid monoethyl ester and N'-methyl-N"-[2-((5-methyl-4-imidazolyl)-methylthio)ethyl]guanidinophospho nic acid monobenzyl ester, are histamine H.sub.2 -antagonists.Type: GrantFiled: August 27, 1979Date of Patent: August 4, 1981Assignee: Smith Kline & French Laboratories LimitedInventors: Graham J. Durant, Rodney C. Young, Zev Tashma
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Patent number: 4278683Abstract: The invention relates to 3,4,5-trihydroxypiperidines, processes for their producion, compositions containing them and methods for the use of said 3,4,5-trihydroxypiperidines and compositions containing them. The compounds and compositions of the invention are useful, inter alia, for their saccharase inhibiting activity in warm-blooded animals as well as their ability to improve feed utilization in warm-blooded and cold-blooded animals.Type: GrantFiled: August 30, 1979Date of Patent: July 14, 1981Assignee: Bayer AktiengesellschaftInventors: Jurgen Stoltefuss, Lutz Muller, Walter Puls, Rudiger Sitt
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Patent number: 4267316Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.Type: GrantFiled: June 14, 1979Date of Patent: May 12, 1981Assignee: Beecham Group LimitedInventors: Kong Luk, John P. Clayton, Norman H. Rogers
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Patent number: 4259330Abstract: This invention relates to novel phosphoramidates of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl, cycloalkyl, or optionally substituted aralkyl, aryl, pyridyl, pyridylmethyl, pyridylethyl or pyrazinyl;R.sup.2 is hydrogen provided R.sup.1 is other than optionally substituted aryl; alkyl; cycloalkyl; alkoxyalkyl; alkylthioalkyl; cyanoalkyl; alkenyl; optionally substituted aralylky; or optionally substituted aryl, provided R.sup.1 is other than hydrogen;R.sup.1 and R.sup.2 taken together with the nitrogen to which they are attached form an optionally substituted morpholino or piperidino group;R.sup.3 is hydrogen, alkyl, cycloalkyl, alkenyl, or optionally substituted aralkyl or aryl;R.sup.4 is (C.sub.1 -C.sub.6) alkyl;R.sup.5 is (C.sub.3 -C.sub.4) alkyl; andX, Y and Z are independently oxygen or sulfur;the agronomically acceptable metal salts and metal salt complexes thereof; and to methods of using them to control nematodes.Type: GrantFiled: March 1, 1976Date of Patent: March 31, 1981Assignee: Rohm and Haas CompanyInventors: Harold E. Aller, Edward E. Kilbourn, Ernest D. Weiler, William D. Weir
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Patent number: 4226999Abstract: A compound of the formula I ##STR1## in which R.sub.2 is an optionally substituted 4-piperidinyl bonded via oxy or imino, or an optionally substituted 2-(piperidino)-ethoxy, n is 1 or 2, R.sub.7 and R.sub.8 are hydrocarbon radicals, R.sub.9 is hydrogen or methyl, R.sub.14 is cyano, --CH.sub.2 OH, a hydroxymethyl which is C-substituted by an optionally substituted 4-piperidinyl bonded via oxy or imino, or by an optionally substituted 2-(piperidino)-ethoxy, or R.sub.14 is also acyl or nitro, and, when n=1, R.sub.15 is hydrogen, a substituted hydroxybenzyl, an optionally substituted hydrocarbon radical, an optionally substituted 4-piperidinyl, or alkylene which is optionally linked to R.sub.14 and optionally substituted, or, when n=2, R.sub.15 is a direct bond or an optionally interrupted hydrocarbon radical, and its salts as stabilizers for organic material.Type: GrantFiled: January 5, 1979Date of Patent: October 7, 1980Assignee: Ciba-Geigy CorporationInventors: Roger Malherbe, Michael Rasberger
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Patent number: 4144224Abstract: New amino phosphonates, containing 2,2,6,6-tetrasubstituted-piperidino moieties and processes for their manufacture are disclosed. These compounds are employed to stabilize organic materials such as polyolefins, polyamides and polyurethanes against degradation from the action of oxygen, heat and light.Type: GrantFiled: November 17, 1977Date of Patent: March 13, 1979Assignee: Ciba-Geigy CorporationInventor: Paul Moser
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Patent number: 4137316Abstract: A new vincamine salt of therapeutic interest is disclosed. The salt is vincamine pyridoxal 5-phosphate and exhibits surprisingly greater activity than vincamine alone. A process for the preparation of the compound is also disclosed.Type: GrantFiled: May 9, 1977Date of Patent: January 30, 1979Assignee: Societe d'Etudes de Produits ChimiquesInventor: Andre Esanu
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Patent number: 4132784Abstract: Compounds are prepared which correspond to the formula ##STR1## wherein each X independently represents chloro, fluoro or bromo; X' represents hydrogen, methyl, chloro, fluoro or bromo; G represents oxygen or sulfur; Z represents oxygen, sulfur, sulfinyl or sulfonyl, with the proviso that Z is attached to the pyridine ring in only the 2 or 4 ring position; D represents cyano, nitro, trifluoromethyl, loweralkyl, loweralkoxy, loweralkylsulfonyl, loweralkylthio, or the radical ##STR2## R represents loweralkoxy, loweralkylamino or diloweralkylamino; R' represents R or phenyl; m represents an integer of from 0 to 4; n represents 0 or 1 and the sum of m + n represents an integer of from 0 to 4.The compounds have been found to be effective insect control agents.Type: GrantFiled: November 3, 1977Date of Patent: January 2, 1979Assignee: The Dow Chemical CompanyInventor: Sudarshan K. Malhotra
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Patent number: 4132783Abstract: Compounds are prepared which correspond to the formula ##STR1## wherein each X independently represents chloro, fluoro or bromo; X' represents hydrogen, methyl, chloro, fluoro or bromo; G represents oxygen or sulfur; Z represents oxygen, sulfur, sulfinyl or sulfonyl, with the proviso that Z is attached to the pyridine ring in only the 2 or 4 ring position; D represents cyano, nitro, trifluoromethyl, loweralkyl, loweralkoxy, loweralkylsulfonyl, loweralkylthio, or the radical ##STR2## R represents loweralkoxy, loweralkylamino or diloweralkylamino; R' represents R or phenyl; m represents an integer of from 0 to 4; n represents 0 or 1 and the sum of m + n represents an integer of from 0 to 4.The compounds have been found to be effective insect control agents.Type: GrantFiled: November 3, 1977Date of Patent: January 2, 1979Assignee: The Dow Chemical CompanyInventor: Sudarshan K. Malhotra
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Patent number: 4128558Abstract: Phosphonic acid esters of the formula ##STR1## in which R.sub.1 and R.sub.2 represent optionally halogen-substituted alkyl or together with --O--P--O-- form a five-membered to seven-membered heterocyclic structure,X represents oxygen or ##STR2## wherein R.sub.4 represents hydrogen or alkyl,R represents alkylene with 1 - 4 carbon atoms andA represents alkylene or 1,2-phenylene, which is optionally substituted by halogen, alkyl or halogenoalkyl and is required to complete a five-membered to seven-membered ring system,Are suitable as flameproofing agents for textiles, plastics and paper.Type: GrantFiled: July 11, 1975Date of Patent: December 5, 1978Assignee: Bayer AktiengesellschaftInventors: Udo W. Hendricks, Klaus Walz