Chalcogen Bonded Directly To Ring Carbon Of The Six-membered Hetero Ring Patents (Class 546/24)
  • Patent number: 4739079
    Abstract: Compounds having the formula ##STR1## wherein ##STR2## R.sub.1 is hydrogen, benzyl or alkanoyl, X is C.sub.2-4 alkylene; andZ-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidiarrheals and antiemetics. Processes for their preparation and intermediates therefor are described.
    Type: Grant
    Filed: March 27, 1986
    Date of Patent: April 19, 1988
    Assignee: Pfizer Inc.
    Inventors: Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4716232
    Abstract: 1-(Vinyl phosphonate adduct) pyrazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: December 29, 1987
    Assignee: Eli Lilly and Company
    Inventor: Robert J. Ternansky
  • Patent number: 4710579
    Abstract: A compound provided by the present invention, of the formula ##STR1## wherein R.sup.1 is C.sub.14-20 alkyl; R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1-5 alkyl, or ##STR2## represents a cyclic ammonio group; and A is C.sub.2-5 alkylene, and a pharmaceutically acceptable salt thereof, are useful as a anti-tumor agent.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: December 1, 1987
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Shoshichi Nojima, Hiroaki Nomura, Tetsuya Okutani
  • Patent number: 4690708
    Abstract: A herbicide of the formula: ##STR1## in which: Z is N or CX',W, Y, Y', X, Z' and X' represent H, a halogen atom, NO.sub.2, CN or a polyhalogenoalkyl, alkyl or alkoxy group,R.sup.2 represents H, halogen, substituted alkyl, allyl, propargyl, CN, NR.sup.4 R.sup.5, C(X.sup.2)R.sup.7, C(X.sup.2)X.sup.3 R.sup.8, C(X.sup.2)NR.sup.4 R.sup.5, SO.sub.2 F, SO.sub.2 OR.sup.8, SO.sub.2 NR.sup.4 R.sup.5 or P(X.sup.2)R.sup.9 R.sup.10,R.sup.1 is halogen, X.sup.2 R.sup.3 or NR.sup.4 R.sup.5,R.sup.3 is optionally substituted alkyl or is allyl or propargyl,R.sup.4, R.sup.7 and R.sup.8 represent H, alkyl, cycloalkyl, phenyl, allyl, propargyl or the like,R.sup.5 represents R.sup.4, a cation or OR.sup.6, R.sup.6 being H, a cation or alkyl,X.sup.2 and X.sup.3 are O or S,R.sup.9 and R.sup.10 are H, alkyl, OH, OM or R.sup.1, andM is a cation.
    Type: Grant
    Filed: July 11, 1984
    Date of Patent: September 1, 1987
    Assignee: Rhone-Poulenc Agrochimie
    Inventors: Alain Chene, Guy Borrod
  • Patent number: 4685952
    Abstract: A benzoylaminoalkylphosphonic acid represented by the following formula (I) ##STR1## wherein X and Y are identical or different, and each represents a hydrogen atom, a halogen atom, CF.sub.3, or an alkyl group having not more than 5 carbon atoms, Z is CH or N, and R.sup.1, R.sup.2 and R.sup.3 are identical or different and each represents a hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms. The compound is useful, as a herbicide, for eradicating weeds, especially broad-leaved weeds.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: August 11, 1987
    Assignee: Teijin Limited
    Inventors: Shizuo Azuma, Toshiyuki Hiramatsu, Koji Nakagawa, Yataro Ichikawa
  • Patent number: 4670040
    Abstract: Novel phenoxypropionyloxyalkanephosphonates of the formula ##STR1## in which R is optionally substituted alkyl andA is optionally substituted alkanediyl,and the use of such new compounds as herbicides.
    Type: Grant
    Filed: January 24, 1985
    Date of Patent: June 2, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Theodor Pfister, Heinz Forster, Ludwig Eue, Robert R. Schmidt, Hans-Joachim Santel
  • Patent number: 4657577
    Abstract: Novel substituted pyridyl-phenyl ethers of the formula ##STR1## in which X represents trifluoromethyl or chlorine,Y represents hydrogen or chlorine,R.sup.1 represents hydrogen or methyl andR.sup.2 represents formyl or the radicals of the formulae ##STR2## in which R.sup.3 represents alkyl with 1 to 4 carbon atoms, or the two radicals R.sup.3 together represent an alkylene chain with 2 or 3 carbon atoms,R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of one another represent hydrogen or alkyl with 1 to 4 carbon atoms,m represents 1 or 2,n represents 0 or 1 andZ represents trimethylsilyl, optionally substituted azolyl which is bonded via nitrogen or the radicals of the formulae ##STR3## in which R.sup.8 represents alkyl with 1 to 4 carbon atoms,or the two radicals R.sup.8 together represent an alkylene chain with 2 or 3 carbon atoms,R.sup.9 represents alkyl with 1 to 4 carbon atoms,X.sup.1 represents oxygen or sulphur andR.sup.10 and R.sup.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: April 14, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Forster, Erich Klauke, Uwe Priesnitz, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt
  • Patent number: 4655816
    Abstract: There are disclosed novel 2,6-substituted-3-pyridinecarboxylic acids, esters, and salts useful as herbicides, and as intermediates which provide herbicides.
    Type: Grant
    Filed: August 27, 1985
    Date of Patent: April 7, 1987
    Assignee: Monsanto Company
    Inventors: Len F. Lee, Maria L. Miller
  • Patent number: 4654072
    Abstract: Compounds having the formula ##STR1## in which R is hydrogen, cyano or --COOR.sub.2 ; R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; and Z is ##STR2## in which A is halogen, B is halogen or hydrogen and Y is nitrogen or --CH--, are herbicides.
    Type: Grant
    Filed: September 17, 1985
    Date of Patent: March 31, 1987
    Assignee: Stauffer Chemical Company
    Inventor: Raymond A. Felix
  • Patent number: 4632697
    Abstract: As new compounds, substituted aryloxyphenoxy benzamides having the formula ##STR1## in which X is nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, cyano or hydrogen; Z is hydrogen, chlorine, bromine, fluorine, iodine, CH.sub.n, F.sub.3-n where n is an integer from 0 to 3; R is nitro, hydrogen or halogen; R' is hydrogen, CH.sub.3, lower alkyl, having 1-10 carbon atoms, SCCl.sub.3, ##STR2## or --PO.sub.3 R.sup.3.sub.2 wherein R.sup.3 is hydrogen, alkyl having 1-10 carbon atoms, aryl, or an equivalent of base such as a salt; R" is cyano, --C.tbd.CH, ##STR3## wherein R.sup.4 is hydrogen, alkyl having 1-10 carbon atoms, aryl or an equivalent of base such as a salt; and m is 0, 1, 2 or 3.These compounds are useful as herbicides.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: December 30, 1986
    Assignee: Stauffer Chemical Company
    Inventor: Sreeramulu Nagubandi
  • Patent number: 4627870
    Abstract: Diphenyl ether derivatives of the formula ##STR1## and tautomers thereof wherein X is selected from the group consisting of chlorine, bromine, iodine, fluorine, methyl, cyano or hydrogen; Y is CF.sub.n H.sub.3-n or chlorine, wherein n is an integer from 0 to 3; R is selected from the group consisting of nitro, hydrogen or halogen; R" is hydrogen, alkyl, phenyl, or substituted alkyl wherein the alkyl group has from 1 to 10 carbon atoms; R"' is the same or different and is selected from C.sub.1 -C.sub.10 alkyl, phenyl or hydrogen; and agriculturally acceptable salts thereof. The compounds are effective as herbicides.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: December 9, 1986
    Assignee: Stauffer Chemical Company
    Inventor: Sreeramulu Nagubandi
  • Patent number: 4607031
    Abstract: An ethyl benzylphosphinate derivative represented by the general formula (I) ##STR1## wherein Y represents a hydrogen or fluorine atom, X represents a methylene group or an oxygen atom, and n is 2, 3 or 4.The said compounds can be produced by reacting a compound represented by the following formula (II) ##STR2## wherein Y is as defined above, with a compound represented by the following formula (III) ##STR3## wherein X and n are as defined, and M is an alkali metal atom, in an inert medium. These compounds are useful as a calcium antagonist.
    Type: Grant
    Filed: May 22, 1985
    Date of Patent: August 19, 1986
    Assignee: Kanebo Ltd.
    Inventors: Koichiro Yoshino, Tominori Morita, Masaru Moriyama, Keizo Ito, Goro Tsukamoto
  • Patent number: 4605741
    Abstract: The present invention relates to a novel pharmacologically active salt derivative, constituted by 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxy-phenyl)-1-butanone 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphate, to the process for the production thereof, and to the related pharmaceutical compositions.Said salt derivative is produced by reacting 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde-5-phosphoric acid with 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-3-butanone in an organic solvent and subsequently crystallizing the reaction product.Said salt derivative carries out an important pharmacological activity as inhibitor of platelet aggregation with vasodilative action.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: August 12, 1986
    Assignee: Lisapharma Spa
    Inventors: Giorgio Zagnoli, Ubaldo Conte, Paolo Colombo
  • Patent number: 4605434
    Abstract: (2-Nitro-5-aryloxy-phenylamino)-alkylphosphine oxide derivatives of the formula I ##STR1## wherein X is halogen, CF.sub.3, NO.sub.2, CN, CONH.sub.2 or CSNH.sub.2,Y is nitrogen or --CH.dbd.,R.sup.1 is hydrogen, C.sub.1 -C.sub.4 -alkyl, or aralkyl having 1-4 carbon atoms in the alkyl moiety,R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.3 is hydrogen, C.sub.1 -C.sub.4 -alkyl, phenyl, benzyl or C.sub.1 -C.sub.4 -alkylbenzyl,R.sup.4 and R.sup.5 independently of one another are each C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.2 -C.sub.6 -alkoxyalkyl, or aralkyl having 1-4 carbon atoms in the alkyl moiety,m is zero to 3, andn is 1 to 3,have useful herbicidal properties.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: August 12, 1986
    Assignee: CIBA-GEIGY Corporation
    Inventor: Ludwig Maier
  • Patent number: 4602946
    Abstract: As new compounds, substituted aryloxy benzoyl amino acid esters having the formula ##STR1## in which R is NO.sub.2, hydrogen or halogen; R' is H, lower alkyl having from about 1 to about 6 carbon atoms, PO.sub.3 R'2, SCC1.sub.3, or any combination thereof; R" is lower alkyl having from about 1 to about 8 carbon atoms, hydrogen, aryl, or a salt-forming cation selected from alkaline earth metals, magnesium, calcium, barium, iron, copper, zinc, and any other agriculturally acceptable salt; n is 1, 2, 3 or 4; W is oxygen, sulfur, or nitrogen; X is CH or nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, hydrogen or cyano; and Z is hydrogen, chlorine, bromine, iodine, fluorine, or CH.sub.m F.sub.3-m where m is the integer 0, 1, 2 or 3. These compounds are useful as herbicides.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: July 29, 1986
    Assignee: Stauffer Chemical Company
    Inventor: Sreeramulu Nagubandi
  • Patent number: 4598071
    Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: July 1, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • Patent number: 4567167
    Abstract: Phosphonamide substituted lactams of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: November 28, 1984
    Date of Patent: January 28, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Donald S. Karanewsky
  • Patent number: 4560752
    Abstract: Novel 5-(substituted amino)phenoxyalkyl-, phenylthioalkyl-, phenylsulfinylalkyl-, and phenylsulfonylalkylphosphinates and phosphonates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.
    Type: Grant
    Filed: June 28, 1984
    Date of Patent: December 24, 1985
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4548929
    Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: October 22, 1985
    Assignee: SDS Biotech Corporation
    Inventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
  • Patent number: 4546106
    Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.
    Type: Grant
    Filed: July 22, 1982
    Date of Patent: October 8, 1985
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
  • Patent number: 4520197
    Abstract: Substituted tetrahydrobenzodiazaphosphorindiones or tetrahydropyridodiazaphosphorindiones, intermediates therefore, synthesis thereof, said compounds being useful herbicides.
    Type: Grant
    Filed: February 1, 1984
    Date of Patent: May 28, 1985
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4470841
    Abstract: A herbicidal composition comprising as an active ingredient a compound of the formula: ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl group, a phenyl group or a C.sub.1 -C.sub.4 alkoxy group, R.sub.2 is a C.sub.1 -C.sub.4 alkyl group, R.sub.3 and R.sub.4, which are the same or different, are each a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or a phenyl group and R.sub.5 is a 2,4-dichlorophenyl group, a 4-trifluoromethylphenyl group or a 5-trifluoromethylpyridin-2-yl group, and an inert carrier.
    Type: Grant
    Filed: August 17, 1982
    Date of Patent: September 11, 1984
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Mitsuru Sasaki, Ryo Yoshida
  • Patent number: 4469687
    Abstract: The invention relates to new chemical compounds corresponding to the following formula ##STR1## in which R is a non-hydrolyzable radical and Az represents aziridinyl ##STR2## These compounds may be used as medicaments.
    Type: Grant
    Filed: September 9, 1981
    Date of Patent: September 4, 1984
    Assignee: Agence Nationale de Valorisation de la Recherche
    Inventors: Jean-Francois Labarre, Francois Sournies, Johan C. van de Grampel, Adriaan A. Van Der Huizen
  • Patent number: 4456465
    Abstract: Novel phenoxyphenyl-substituted or pyridyloxyphenyl-substituted phosphinates and phosphinothioates, syntheses thereof, intermediates therefor, and the use of said novel phosphinates and phosphinothioates for the control of weeds.
    Type: Grant
    Filed: January 10, 1983
    Date of Patent: June 26, 1984
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4433149
    Abstract: Substituted tetrahydrobenzodiazaphosphorindiones or tetrahydropyridodiazaphosphorindiones, intermediates therefore, synthesis thereof, said compounds being useful herbicides.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: February 21, 1984
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4424359
    Abstract: Vinyl-substituted 2,2'-bipyridine compounds of the formula ##STR1## and complexes thereof with metals or metal compounds other than alkali metals or alkaline earth metals, or alkali metal compounds, or alkaline earth metal compounds are described, R.sub.1 and R.sub.2 being as defined in patent claim 1 and the vinyl group being bonded in the 4-position or 6-position. The 2,2'-bipyridine compounds (I) are suitable for the preparation of complex-forming or complexed, crosslinked or uncrosslinked polymers. Complexed polymers, obtainable from these, are used, for example, as catalysts, in particular for transvinylation reactions. Uncomplexed polymers, which can be prepared from compounds (I), are suitable as metal ion scavengers in various applications.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: January 3, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Ju/ rgen Kaschig, Dieter Lohmann
  • Patent number: 4424213
    Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.
    Type: Grant
    Filed: November 2, 1981
    Date of Patent: January 3, 1984
    Assignee: SDS Biotech Corporation
    Inventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
  • Patent number: 4416831
    Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: November 1, 1982
    Date of Patent: November 22, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.
  • Patent number: 4374131
    Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: February 15, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.
  • Patent number: 4364767
    Abstract: There are provided N(carboxymethyl-N-(phosphonomethyl)-5-(2-chloro-4-trifluoromethyl phenoxy)-2-nitrobenzamide and salts thereof.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: December 21, 1982
    Assignee: Rhone-Poulenc Agrochimie
    Inventor: Stanley T. D. Gough
  • Patent number: 4355034
    Abstract: Mercaptoalkylpyridines carrying an ethenyl or ethynyl substituent are prepared from known pyridine compounds, principally pyridoxine, by known chemical procedures, and are useful in the treatment of rheumatoid arthritis and related inflammatory diseases.
    Type: Grant
    Filed: July 25, 1980
    Date of Patent: October 19, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones, Conrad P. Dorn
  • Patent number: 4347194
    Abstract: Polyhydroxyl polyether compounds containing at least one monomeric unit each of the formulae: ##STR1## are disclosed. Polymeric condensation resins are prepared by allowing the polyhydroxyl polyethers to react with polyfunctional chain-forming compounds containing functional groups reactive with the hydroxyl groups of polyhydroxyl polyethers. The polyhydroxyl polyether compounds enhance the flame-retardant properties of polymeric condensation resins such as polyurethanes.
    Type: Grant
    Filed: May 11, 1981
    Date of Patent: August 31, 1982
    Assignee: The Dow Chemical Co.
    Inventors: Sally P. Ginter, Chester E. Pawloski, Violete L. Stevens
  • Patent number: 4330536
    Abstract: Oxime phosphates of the formula ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 -alkyl,R.sub.2 is C.sub.1 -C.sub.7 -alkoxy or C.sub.1 -C.sub.6 -alkylthio,R.sub.3 is hydrogen, C.sub.1 -C.sub.6 -alkyl or cyano,A.sub.1, A.sub.2, A.sub.3 and A.sub.4 are each hydrogen or halogen,A.sub.5 is hydrogen, halogen, trifluoromethyl or C.sub.1 -C.sub.6 -alkyl, andX is oxygen or sulfur,a process for producing them, and their use for combating pests.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: May 18, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Georg Pissiotas, Ernst Beriger
  • Patent number: 4327089
    Abstract: A novel O-(N-alkoxy-pyridinecarboximidoyl)-phosphate represented by the following formula: ##STR1## wherein X is a halogen atom, a lower alkyl group, a lower acyloxy group, a trifluoromethyl group or a nitro group; Y is an oxygen atom or a sulfur atom; R is a lower alkyl group; n is an integer of 0 to 3; and Z.sub.1 and Z.sub.2 are each a lower alkoxy group, a lower alkylthio group, a phenyl group which may be substituted by a lower alkyl group, a phenoxy group, a haloalkoxy group or a lower alkylamino group, useful as an active ingredient of insecticides or acaricides.
    Type: Grant
    Filed: December 12, 1980
    Date of Patent: April 27, 1982
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Takahiro Haga, Tadaaki Toki, Toru Koyanagi, Osamu Imai
  • Patent number: 4322531
    Abstract: The invention relates to diazaphospholanes and diazaphosphorinanes of the formula I ##STR1## in which m is 0 or 1, n is 1 or 2 and R.sup.1 to R.sup.4 are as defined in claim 1. These compounds are effective light stabilizers for organic materials, especially for polymers. In addition, they can also possess an antioxidant and/or a flame retardant action. They can be obtained from the corresponding diamines by a cyclization reaction with the phosphorus dichlorides R.sup.3 P(O).sub.m Cl.sub.2.
    Type: Grant
    Filed: September 18, 1980
    Date of Patent: March 30, 1982
    Assignee: Ciba-Geigy Corporation
    Inventor: Friedrich Karrer
  • Patent number: 4282213
    Abstract: Amidine phosphonates carrying an unsaturated nitrogen heterocycle-containing substituent, representative of which are N-methyl-N'-[2-(2-thiazolylmethylthio)ethyl]amidinophosphonic acid monoethyl ester and N'-methyl-N"-[2-((5-methyl-4-imidazolyl)-methylthio)ethyl]guanidinophospho nic acid monobenzyl ester, are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: August 4, 1981
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Rodney C. Young, Zev Tashma
  • Patent number: 4278683
    Abstract: The invention relates to 3,4,5-trihydroxypiperidines, processes for their producion, compositions containing them and methods for the use of said 3,4,5-trihydroxypiperidines and compositions containing them. The compounds and compositions of the invention are useful, inter alia, for their saccharase inhibiting activity in warm-blooded animals as well as their ability to improve feed utilization in warm-blooded and cold-blooded animals.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: July 14, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Stoltefuss, Lutz Muller, Walter Puls, Rudiger Sitt
  • Patent number: 4267316
    Abstract: Esters of an acid of formula: ##STR1## which is termed "monic acid" have activity against Gram-positive and Gram-negative organisms.
    Type: Grant
    Filed: June 14, 1979
    Date of Patent: May 12, 1981
    Assignee: Beecham Group Limited
    Inventors: Kong Luk, John P. Clayton, Norman H. Rogers
  • Patent number: 4259330
    Abstract: This invention relates to novel phosphoramidates of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl, cycloalkyl, or optionally substituted aralkyl, aryl, pyridyl, pyridylmethyl, pyridylethyl or pyrazinyl;R.sup.2 is hydrogen provided R.sup.1 is other than optionally substituted aryl; alkyl; cycloalkyl; alkoxyalkyl; alkylthioalkyl; cyanoalkyl; alkenyl; optionally substituted aralylky; or optionally substituted aryl, provided R.sup.1 is other than hydrogen;R.sup.1 and R.sup.2 taken together with the nitrogen to which they are attached form an optionally substituted morpholino or piperidino group;R.sup.3 is hydrogen, alkyl, cycloalkyl, alkenyl, or optionally substituted aralkyl or aryl;R.sup.4 is (C.sub.1 -C.sub.6) alkyl;R.sup.5 is (C.sub.3 -C.sub.4) alkyl; andX, Y and Z are independently oxygen or sulfur;the agronomically acceptable metal salts and metal salt complexes thereof; and to methods of using them to control nematodes.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: March 31, 1981
    Assignee: Rohm and Haas Company
    Inventors: Harold E. Aller, Edward E. Kilbourn, Ernest D. Weiler, William D. Weir
  • Patent number: 4226999
    Abstract: A compound of the formula I ##STR1## in which R.sub.2 is an optionally substituted 4-piperidinyl bonded via oxy or imino, or an optionally substituted 2-(piperidino)-ethoxy, n is 1 or 2, R.sub.7 and R.sub.8 are hydrocarbon radicals, R.sub.9 is hydrogen or methyl, R.sub.14 is cyano, --CH.sub.2 OH, a hydroxymethyl which is C-substituted by an optionally substituted 4-piperidinyl bonded via oxy or imino, or by an optionally substituted 2-(piperidino)-ethoxy, or R.sub.14 is also acyl or nitro, and, when n=1, R.sub.15 is hydrogen, a substituted hydroxybenzyl, an optionally substituted hydrocarbon radical, an optionally substituted 4-piperidinyl, or alkylene which is optionally linked to R.sub.14 and optionally substituted, or, when n=2, R.sub.15 is a direct bond or an optionally interrupted hydrocarbon radical, and its salts as stabilizers for organic material.
    Type: Grant
    Filed: January 5, 1979
    Date of Patent: October 7, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Roger Malherbe, Michael Rasberger
  • Patent number: 4144224
    Abstract: New amino phosphonates, containing 2,2,6,6-tetrasubstituted-piperidino moieties and processes for their manufacture are disclosed. These compounds are employed to stabilize organic materials such as polyolefins, polyamides and polyurethanes against degradation from the action of oxygen, heat and light.
    Type: Grant
    Filed: November 17, 1977
    Date of Patent: March 13, 1979
    Assignee: Ciba-Geigy Corporation
    Inventor: Paul Moser
  • Patent number: 4137316
    Abstract: A new vincamine salt of therapeutic interest is disclosed. The salt is vincamine pyridoxal 5-phosphate and exhibits surprisingly greater activity than vincamine alone. A process for the preparation of the compound is also disclosed.
    Type: Grant
    Filed: May 9, 1977
    Date of Patent: January 30, 1979
    Assignee: Societe d'Etudes de Produits Chimiques
    Inventor: Andre Esanu
  • Patent number: 4132783
    Abstract: Compounds are prepared which correspond to the formula ##STR1## wherein each X independently represents chloro, fluoro or bromo; X' represents hydrogen, methyl, chloro, fluoro or bromo; G represents oxygen or sulfur; Z represents oxygen, sulfur, sulfinyl or sulfonyl, with the proviso that Z is attached to the pyridine ring in only the 2 or 4 ring position; D represents cyano, nitro, trifluoromethyl, loweralkyl, loweralkoxy, loweralkylsulfonyl, loweralkylthio, or the radical ##STR2## R represents loweralkoxy, loweralkylamino or diloweralkylamino; R' represents R or phenyl; m represents an integer of from 0 to 4; n represents 0 or 1 and the sum of m + n represents an integer of from 0 to 4.The compounds have been found to be effective insect control agents.
    Type: Grant
    Filed: November 3, 1977
    Date of Patent: January 2, 1979
    Assignee: The Dow Chemical Company
    Inventor: Sudarshan K. Malhotra
  • Patent number: 4132784
    Abstract: Compounds are prepared which correspond to the formula ##STR1## wherein each X independently represents chloro, fluoro or bromo; X' represents hydrogen, methyl, chloro, fluoro or bromo; G represents oxygen or sulfur; Z represents oxygen, sulfur, sulfinyl or sulfonyl, with the proviso that Z is attached to the pyridine ring in only the 2 or 4 ring position; D represents cyano, nitro, trifluoromethyl, loweralkyl, loweralkoxy, loweralkylsulfonyl, loweralkylthio, or the radical ##STR2## R represents loweralkoxy, loweralkylamino or diloweralkylamino; R' represents R or phenyl; m represents an integer of from 0 to 4; n represents 0 or 1 and the sum of m + n represents an integer of from 0 to 4.The compounds have been found to be effective insect control agents.
    Type: Grant
    Filed: November 3, 1977
    Date of Patent: January 2, 1979
    Assignee: The Dow Chemical Company
    Inventor: Sudarshan K. Malhotra
  • Patent number: 4128558
    Abstract: Phosphonic acid esters of the formula ##STR1## in which R.sub.1 and R.sub.2 represent optionally halogen-substituted alkyl or together with --O--P--O-- form a five-membered to seven-membered heterocyclic structure,X represents oxygen or ##STR2## wherein R.sub.4 represents hydrogen or alkyl,R represents alkylene with 1 - 4 carbon atoms andA represents alkylene or 1,2-phenylene, which is optionally substituted by halogen, alkyl or halogenoalkyl and is required to complete a five-membered to seven-membered ring system,Are suitable as flameproofing agents for textiles, plastics and paper.
    Type: Grant
    Filed: July 11, 1975
    Date of Patent: December 5, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Udo W. Hendricks, Klaus Walz