Two Ring Nitrogens In The Tetracyclo Ring System Patents (Class 546/70)
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Patent number: 5629317Abstract: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.Type: GrantFiled: May 19, 1995Date of Patent: May 13, 1997Assignee: Eli Lilly and CompanyInventors: James E. Audia, Stephen R. Baker, Jesus E. Carrera, Carlos L. Peteira, Concepcion P. Tercero
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Patent number: 5622957Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.Type: GrantFiled: May 3, 1995Date of Patent: April 22, 1997Assignee: Adir et CompagnieInventors: Jean-Daniel Brion, Claude Thal, Luc Demuynck, Jean-Gilles Parmentier, Jean Lepagnol, Pierre Lestage, Jean-Fran.cedilla.ois Pujol, Pascal Schmitt, Pierre Potier
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Patent number: 5608066Abstract: Methods for purifying 20(S)-camptothecin are described. The 20(S)-camptothecin in purified form is useful in the treatment of cancer.Type: GrantFiled: June 6, 1995Date of Patent: March 4, 1997Assignee: The Stehlin Foundation for Cancer ResearchInventor: Hellmuth R. Hinz
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Patent number: 5602131Abstract: A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.Type: GrantFiled: December 13, 1994Date of Patent: February 11, 1997Assignee: Adir et CompagnieInventors: Jean-Daniel Brion, Claude Thal, Luc Demuynck, Jean-Gilles Parmentier, Jean Lepagnol, Pierre Lestage, Jean-Fran.cedilla.ois Pujol, Pascal Schmitt, Pierre Potier
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Patent number: 5597832Abstract: A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached and the optional double bond represent a mono- or di-heterocyclic ring selected from: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder.Type: GrantFiled: November 10, 1994Date of Patent: January 28, 1997Assignee: Abbott LaboratoriesInventors: Michael R. Michaelides, Yufeng Hong
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Patent number: 5585382Abstract: Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.9 and R.sup.10 are independently selected from the group H, C.sub.1 -C.sub.4 alkyl, OR.sup.4, N(R.sup.4).sub.2, NO.sub.2, CN, F, Cl, Br, I, Ph, and CF.sub.3, and NHC(O)R.sup.4 ;R.sup.4 is independently selected from the group H, C.sub.1 -C.sub.4 alkyl, Ph, and CH.sub.2 Ph;X.sup.1 and Y.sup.1, and X.sup.2 and Y.sup.2 when present, join together to form:a benzene ring substituted with 1-4 R.sup.3 ;a five membered heterocycle having 1-2N, NH, O or S atoms and substituted with 1-2 R.sup.3 ;a six membered heterocycle having 1-2N and substituted with 1-2 R.sup.3 ; orthe group: ##STR2## wherein one of W or Z is C.dbd.O and the other is C.dbd.O, NH, S or O; or when X.sup.2 and Y.sup.2 are present and not joined together and when R.sup.2 is in the 4-position, then X.sup.2 and R.sup.2 may join together to form an ethylene bridge;are addressed.Type: GrantFiled: February 21, 1995Date of Patent: December 17, 1996Assignee: The DuPont Merck Pharmaceutical CompanyInventors: Arthur D. Patten, Gregory Pacofsky, Steven P. Seitz, Emeka A. Akamike, Robert J. Cherney, Robert F. Kaltenbach, III, Michael J. Orwat
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Patent number: 5565569Abstract: An ellipticine derivative of the formula [I]: ##STR1## wherein R is a substituted lower alkyl group, a substituted or unsubstituted lower alkoxy group or a heteromonocyclic group,or a pharmaceutically acceptable salt thereof, which show excellent antitumor activity, less side effects, less toxicity and/or high solubility in water and are useful as antitumor agent, and a process for preparing the same.Type: GrantFiled: January 25, 1994Date of Patent: October 15, 1996Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Kenji Tsujihara, Naoyuki Harada, Kunihiko Ozaki, Motoaki Ohashi, Koji Oda
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Patent number: 5554632Abstract: The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.Type: GrantFiled: December 9, 1994Date of Patent: September 10, 1996Assignees: NeuroSearch A/S, Meiji Seika Kaisha, Ltd.Inventors: Lene Teuber, Oskar Axelsson, Frank Watjen
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Patent number: 5538980Abstract: The present invention provides novel tetrahydro-beta-carboline compounds and intermediates having useful central nervous system activity.Type: GrantFiled: May 10, 1995Date of Patent: July 23, 1996Assignee: Eli Lilly and CompanyInventors: James E. Audia, James J. Droste, Deborah A. Evrard
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Patent number: 5527913Abstract: Methods for purifying 20(S)-camptothecin are described. The 20(S)-camptothecin in purified form is useful in the treatment of cancer.Type: GrantFiled: February 23, 1994Date of Patent: June 18, 1996Assignee: The Stehlin Foundation for Cancer ResearchInventor: Hellmuth R. Hinz
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Patent number: 5525609Abstract: The present invention relates to novel alkaloids from Mappia foetida, foetidine 1 and 2, having anticancer and antiviral properties. These alkaloids, soluble in water, are present in all the parts of the plant, and are the precursors of camptothecin and of 9-methoxy-camptothecin, which are alkaloids known to have pharmacodynamic properties but also to be insoluble in water. The particular water solubility of the novel compounds make them particularly suitable for the treatment of the patients by the parenteral route, avoiding the use of toxic excipients or of unsuitable chemical derivatizations.Type: GrantFiled: July 11, 1994Date of Patent: June 11, 1996Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Giuseppe Mustich, Luisella Verotta
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Patent number: 5508284Abstract: The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided 3-ethanamine and 3-ethanamine related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds.Type: GrantFiled: May 23, 1995Date of Patent: April 16, 1996Assignee: Eli Lilly and CompanyInventors: James E. Audia, James J. Droste, Deborah A. Evrard, Pawel Fludzinski, Gwyn L. Murdoch, David L. Nelson
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Patent number: 5498611Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined in the description, and medicaments containing the same.Type: GrantFiled: July 21, 1994Date of Patent: March 12, 1996Assignee: Adir et CompagnieInventors: E. Bisagni, R. Jasztold-Howorko, G. Atassi, A. Pierre
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Patent number: 5441956Type: GrantFiled: January 5, 1994Date of Patent: August 15, 1995Assignee: Smithkline Beecham Farmaceutici S.p.A.Inventors: Vittorio Vecchietti, Giulio Dondio, Silvano Ronzoni, Roberto Colle
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Patent number: 5441941Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.Type: GrantFiled: December 21, 1993Date of Patent: August 15, 1995Assignees: The United States of America as represented by the Secretary of DHHS, Purdue Research FoundationInventors: Rudiger D. Haugwitz, Venkatachiala L. Narayanan, Mark Cushman, Jurjus Jurayj
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Patent number: 5439916Abstract: Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.Type: GrantFiled: August 31, 1990Date of Patent: August 8, 1995Assignee: Schering CorporationInventors: Ashit K. Ganguly, Richard J. Friary, John H. Schwerdt, Marvin I. Siegel, Sidney R. Smith, Edmund J. Sybertz
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Patent number: 5416089Abstract: Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected H, CH.sub.3, NH.sub.2, NO.sub.2, and CN;R.sup.9 and R.sup.10 are H or alkyl or halo, X.sup.1 and Y.sup.1 or X.sup.2 and Y.sup.2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R.sup.3 ; or the group: ##STR2## wherein one of W or Z is C.dbd.O and the other is C.dbd.O, NH, S or O; or when X.sup.2 and Y.sup.2 are not joined together and when R.sup.2 is in the 4-position, then X.sup.2 and R.sup.2 may join together to form an ethylene bridge; are disclosed.Type: GrantFiled: June 24, 1993Date of Patent: May 16, 1995Assignee: The Du Pont Merck Pharmaceutical CompanyInventors: Arthur D. Patten, Gregory Pacofsky, Steven P. Seitz, Emeka A. Akamike, Robert J. Cherney, Robert F. Kaltenbach, III, Michael J. Orwat
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Patent number: 5407940Abstract: The invention relates to a compound selected from those of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined in the specification, and medicaments.Type: GrantFiled: October 1, 1993Date of Patent: April 18, 1995Assignee: ADIR et CompagnieInventors: E. Bisagni, R. Jasztold-Howorko, G. Atassi, A. Pierre
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Patent number: 5371000Abstract: A process for the production of ergoline derivatives of general formula I is described ##STR1## in which the bonds represent two single-bonds or a double bond and a single bond.R.sub.1 means a hydrogen atom or an alkyl group with 1-6 carbon atomsR.sub.2 symbolizes a hydrogen atom or an alkyl group with 1-6 carbon atoms,R.sub.3 represents a carboxyl group or a grouping of formula--CONR.sub.4 R.sub.5 or --NHCQNR.sub.6 R.sub.7with R.sub.4 and R.sub.5 meaning hydrogen or an alkyl radical with 1-6 carbons atoms optionally substituted by a hydroxy group and R.sub.6 and R.sub.7 meaning an alkyl group containing 1-4 carbon atoms and Q meaning an oxygen or sulfur atom.Type: GrantFiled: October 7, 1992Date of Patent: December 6, 1994Assignee: Schering AktiengesellschaftInventors: Heidi Hummel-Maquardt, Mario Kennecke, Alfred Weber, Klaus Nickisch, Gregor Haffer
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Patent number: 5352790Abstract: The invention relates to a novel process for the preparation of (-) -1.beta.-ethyl-1.alpha.-(hydroxymethyl) - 1,2,3,4,6,7,12,12b.alpha.-octahydro-indolo[2,3-a]quinolizine of the formula (I) ##STR1## and to novel intermediates obtained in this process. The compound of the formula (I) prepared by the process of the invention possesses a peripheral vasodilator effect.Type: GrantFiled: June 25, 1992Date of Patent: October 4, 1994Assignee: Richter Gedeon Vegeyszeti Gyar Rt.Inventors: Janos Kreidl, Laszlo Czibula, Gyorgy Visky, Maria F. nee Kirjak, Ida D. nee Juhasz, Judit Brill, deceased, Katalin Nogradi
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Patent number: 5352789Abstract: Methods for purifying camptothecin compounds are described. The camptothecin compounds in purified form are useful in the treatment of cancer.Type: GrantFiled: February 25, 1993Date of Patent: October 4, 1994Assignee: The Stehlin Foundation for Cancer ResearchInventor: Hellmuth R. Hinz
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Patent number: 5310909Abstract: Compounds of the formula I ##STR1## in which X is O, S, SO, SO.sub.2 or NR.sub.13, R.sub.13 is, for example, methyl, and R.sub.1 to R.sub.12, independently of one another, are, for example, H, C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 Alkoxy, halogen or --CN. The compounds are photosensitive and photochromic and are suitable as photosensitizers and simultaneously as color indicators, and as photoswitchable color filters.Type: GrantFiled: November 21, 1990Date of Patent: May 10, 1994Assignee: Ciba-Geigy CorporationInventors: Evelyn Fischer, Walter Fischer, Jurgen Finter, Kurt Meier, Martin Roth
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Patent number: 5304554Abstract: Novel 4-[(alkyl or dialkyl)amino]quinolines are disclosed that are prepared by condensinBACKGROUND OF THE INVENTIONThe United States government has rights in this invention as a result of a grant from the NIAID of the National Institute of Health, Bethesda, Md.Type: GrantFiled: March 11, 1992Date of Patent: April 19, 1994Assignees: Emory University, Georgia State University Research FoundationInventors: Lucjan Strekowski, Roman L. Wydra, Steven E. Patterson, Raymond F. Schinazi
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Patent number: 5300645Abstract: The present invention provides a new Pictet-Spengler process useful for preparing tetrahydro-beta-carboline compounds.Type: GrantFiled: April 14, 1993Date of Patent: April 5, 1994Assignee: Eli Lilly and CompanyInventors: James E. Audia, James J. Droste, Deborah A. Evrard
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Patent number: 5292747Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X, m, n, p, and q are as set forth in the specification, as well as pharmaceutically acceptable salts of acidic compounds of formula I with bases and of basic compounds of formula I with acids, which are useful in the control or prevention of inflammatory, immunological, oncological, bronchopulmonary, dermatological or cardiovascular disorders or for the treatment of asthma, AIDS or diabetic complications or for the stimulation of hair growth are described.Type: GrantFiled: September 21, 1992Date of Patent: March 8, 1994Assignee: Hoffman-La Roche Inc.Inventors: Peter D. Davis, Christopher H. Hill, Goeffrey Lawton
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Patent number: 5272146Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.Type: GrantFiled: October 2, 1992Date of Patent: December 21, 1993Assignees: The United States of America as represented by the United States Department of Health and Human Services, Purdue Research FoundationInventors: Rudiger D. Haugwitz, Venkatachala L. Narayanan, Mark Cushman, Jurjus Jurayj
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Patent number: 5250537Abstract: 5,6,7,8,9,10-Hexahydro-7,10-iminocyclohept[b]indole, 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives are effective in the treatment of psychoses with limited liability to produce concomitant adverse extrapyramidal symptoms. These compounds are also useful for treating other central nervous system and cardiovascular disorders.Type: GrantFiled: March 13, 1992Date of Patent: October 5, 1993Assignee: Scios Nova Inc.Inventors: Richard E. Mewshaw, Carl Kaiser, Mary E. Abreu
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Patent number: 5244904Abstract: This invention is directed to a indole derivative represented by the general formula (1) ##STR1## wherein R.sub.1 stands for alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, cycloalkenylalkyl of 5 to 7 carbon atoms, aralkyl of 7 to 14 carbon atoms, trans-alkenyl of 4 to 5 carbon atoms, allyl, furanyl-2-ylalkyl of 1 to 5 carbon atoms, thienyl-2-ylalkyl of 1 to 5 carbon atoms, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, alkanoyl of 1 to 5 carbon atoms, aralkylcarbonyl of 7 to 14 carbon atoms, 2-furoyl, thiophene-2-carbonyl, cycloalkylcarbonyl of 4 to 7 carbon atoms, alkenylcarbonyl of 3 to 8 carbon atoms, or anisoyl, R.sub.2 for a hydrogen atoms, alkyl of 1 to 3 carbon atoms, benzyl, or alkanoyl of 1 to 5 carbon atoms, R.sub.3 for a hydrogen atoms, a fluorine atom, a chlorine atom, a bromine atom, nitro, or alkyl of 1 to 5 carbon atoms, R.sub.4 for a hydrogen atom, alkyl of 1 to 5 carbon atoms, benzyl, or phenyl, and R.sub.Type: GrantFiled: January 29, 1992Date of Patent: September 14, 1993Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Akira Mizusuna, Yoshihiro Onoda, Koji Kawai, Shu Matsumoto, Takashi Endo
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Patent number: 5231181Abstract: The invention provides a process for preparing single enantiomers of compounds represented by the formula: ##STR1## and chiral acid addition salts thereof; wherein: X and Y are independently hydrogen; lower alkyl; lower alkoxy; or halo; or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy;which includes reduction of a compound represented by the formula: ##STR2## to give a mixture of stereoisomers represented by the formula: ##STR3## wherein each wavy line independently represents a bond in either the .alpha. or .beta. position;followed by dissolving the mixture of stereoisomers and a chiral resolving acid in a suitable solvent and allowing the solution to crystallize, giving a salt of the desired enantiomer.Type: GrantFiled: March 21, 1991Date of Patent: July 27, 1993Assignee: Syntex (U.S.A.) Inc.Inventors: Norman H. Dyson, John O. Gardner, John C. Rohloff
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Patent number: 5229387Abstract: Compounds of the formula ##STR1## wherein: m is an integer of 1-6;n is an integer of 1 or 2;X and Y are independently hydrogen; hydroxy; lower alkyl; lower alkoxy; or halo; or X and Y when adjacent and taken together are methylenedioxy or ethylene-1,2-dioxy;R is ##STR2## wherein: R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl, or when taken together with the carbon to which they are attached are cycloalkyl;R.sup.3 is hydrogen, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl or halo; and ##STR3## and pharmaceutically acceptable acid addition salts thereof. The compounds and salts exhibit useful pharmacological properties, including selective .alpha..sub.2 -adrenoceptor antagonist properties and 5-HT.sub.1A receptor partial agonist properties, and are particularly useful for the treatment of sexual dysfunction, depression and anxiety.Type: GrantFiled: September 20, 1991Date of Patent: July 20, 1993Assignee: Syntex (U.S.A.) Inc.Inventors: Robin D. Clark, Brian H. Vickery, Mike Spedding
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Patent number: 5223625Abstract: The invention relates to a group of new annelated indolo [3,2-c] lactam derivatives of the formula ##STR1## having an antagonistic activity on 5-HT receptors. The compounds can be used for the treatment of symptoms which are caused by excessive stimulation of said receptors in the gastrointestinal system, the central nervous system, the cardiovascular system, the respiratory system, and for alleviating or preventing withdrawal symptoms which are induced by abuse of drugs.Type: GrantFiled: July 16, 1992Date of Patent: June 29, 1993Assignee: Duphar International Research B.V.Inventors: Ineke Van Wijngaarden, Hans H. Haeck, Derk Hamminga, Wouter Wouters
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Patent number: 5218119Abstract: The present invention relates to racemic or optically active cis octahydro-indolo [2,3-a] quinolizine diester derivatives.Type: GrantFiled: January 13, 1992Date of Patent: June 8, 1993Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Janos Kreidl, Maria Farkas nee Kirjak, Katalin Nogradi, Ida Deutsch nee Juhasz, Judit Meszaros nee Brill, deceased, Bela Stefko, Gyorgy Visky, Zsuzsanna Aracs nee Tischler, Bela Benke, Maria Stiller, Ferenc Drexler
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Patent number: 5217961Abstract: The present invention provides condensed quinoline compounds represented by the following general formula (I): ##STR1## in which Z is NH, X is hydrogen, L is lower alkoxy, M is NHQ, Q is --SO.sub.2 CH.sub.3, Y is --NHR, and R is: ##STR2## These compounds are effective for inhibiting KB-cell growth and prolongation of the life span of mice implanted with tumor P-388.Type: GrantFiled: September 16, 1991Date of Patent: June 8, 1993Assignee: Mect CorporationInventors: Masatoshi Yamato, Kuniko Hashigaki
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Patent number: 5164212Abstract: A method for permanently coloring fruits (cherries) and vegetables using carmine and other anthraquinones, using mixtures of multivalent metal ions and acid. The cherries are infused with a mixture of calcium ions, other multivalent metal ions, and carmine dye, at a pH at which the carmine is in soluble form. The cherries are then infused with an acidification solution which results in the preciptation of an insoluble carmine-metal ion complex within the cherries. Unused dye is treated and recycled.Type: GrantFiled: August 23, 1991Date of Patent: November 17, 1992Assignee: Del Monte CorporationInventors: Karim Nafisi-Novaghar, Dorothy K. Keefer, Jurgen H. Strasser, Lowell V. Dravenstadt, Russell A. Lem
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Patent number: 5159080Abstract: Compounds of the formula ##STR1## wherein R.sub.1 to R.sub.8, which may be identical to or different from each other, have diverse meanings, and the dotted line between the carbon atoms in the 4- and 4a- position or the 4a- and 5-position or the 42- and 12a position may be a single or double bond, or pharmaceutically acceptable salts thereof, as well as a process for the preparation of these compounds, and pharmaceutical compositions containing these compounds. The compounds and their salts are useful for the treatment of heart-circulation disorders.Type: GrantFiled: December 18, 1990Date of Patent: October 27, 1992Assignee: Madaus AGInventors: Klaus Goler, Wolf Grimminger, Karl P. Odenthal, Pierre Potier
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Patent number: 5155225Abstract: A method for making 8-methyl-7-(1-oxopropyl)indolizino[1,2-b]quinolin-9(11H)-ones from 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12 H)-diones, said method being graphically illustrated as follows: ##STR1##Type: GrantFiled: September 28, 1990Date of Patent: October 13, 1992Assignee: SmithKline Beecham CorporationInventors: Joseph M. Fortunak, Mark Mellinger, Jeffery L. Wood
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Patent number: 5128345Abstract: Novel indoloquinoline compounds of formula (I), benzo(b)acridines of formula (II) and benzo(c)acridines of formula (III) have carcinostatic activities. The compounds, processes for preparing the compounds via nucleophilic aromatic substitution, and carcinostatic compositions containing the same are disclosed.Type: GrantFiled: March 3, 1989Date of Patent: July 7, 1992Assignee: Mect CorporationInventor: Masatoshi Yamato
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Patent number: 5122607Abstract: New intermediate compounds are disclosed of the formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl having 1 to 4 carbon atoms,or acid-addition salts thereof of formula Ib, ##STR2## wherein X represents an acid residue, and a process for the preparation of the intermediate compounds.Type: GrantFiled: June 21, 1990Date of Patent: June 16, 1992Assignee: Richter Gedeon Vegyesczeti Gyar RT.Inventors: Janos Kreidl, Csaba Szantay, Lajos Szaho, Maria Farkas nee Kirjak, Gyorgy Kalaus, Katalin Nogradi, Andras Nemes, Judit Meszaros nee Brill, Zsuzsanna Aracs nee Tischler, Bela Stefko, Janos Sapi, Ida Deutsch nee Juhasz, Istvan Hegedus, Bela Benke, Kalman Graf, Kalmam Gaf, Katalin Horvath nee Berki
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Patent number: 5091388Abstract: New pyridobenzoindole derivatives of general formula (I), in which R is H or alkyl (1 or 2 C), alk is straight or branched alkylene (2 to 4 C), R.sub.1 denotes a hydrogen atom or an alkyl radical (1 or 2 C), R.sub.2 denotes a hydroxy or methoxy radical, and R.sub.3 is methyl or ethyl and their addition salts with acids, useful as antitumor agents.Type: GrantFiled: June 5, 1990Date of Patent: February 25, 1992Assignee: Rhone-Poulenc SanteInventors: Emile Bisagni, Chi-Hung Nguyen
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Patent number: 5079363Abstract: The subject of the present invention is a process for the preparation of isoquinoline derivatives in four steps wherein use is made as synthetic intermediates of organo-lithium compounds or related compounds.Type: GrantFiled: February 22, 1989Date of Patent: January 7, 1992Assignee: SanofiInventors: Michel Bouisset, Andre Bousquet, Jean-Robert Dormoy, Alain Heymes
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Patent number: 5079246Abstract: A compound for formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and Z are described in claim 1.Type: GrantFiled: December 7, 1989Date of Patent: January 7, 1992Assignee: Beacham Group p. l. c.Inventors: Ian T. Forbes, Roger T. Martin, Mervyn Thompson
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Patent number: 5076831Abstract: Substituted 1,8-naphthalenedicarboximides of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X, Y, and Z have the meanings recited in the disclosure are disclosed as new compounds suitable for use as antidotes in herbicidal compositions.Type: GrantFiled: November 20, 1990Date of Patent: December 31, 1991Assignee: BASF AktiengesellschaftInventors: Thomas Saupe, Norbert Meyer, Peter Plath, Ulrich Schirmer, Bruno Wuerzer, Karl-Otto Westphalen, Manfred Patsch, Juergen Pfister
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Patent number: 5039804Abstract: A method of preparing certain substituted alkali metal 4-carboxy-piperidine salts (I) by alkaline hydrolysis of certain novel substituted 1,3,8-triazaspiro[4.5]decane-2, 4-diones (IV) which in turn are obtained from certain novel substituted chlorosulphonylamido piperidines (III).Type: GrantFiled: December 13, 1989Date of Patent: August 13, 1991Assignee: Glaxo Inc.Inventors: Paul L. Feldman, Marcus F. Brackeen
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Patent number: 4997831Abstract: The invention provides lactam derivatives of the general formula (I) ##STR1## wherein n represents 2 or 3; Im represents an imidazolyl group of the formula: ##STR2## wherein one of the groups represented by R.sup.1, R.sup.2 and R.sup.3 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, phenyl or phenylC.sub.1-3 alkyl- group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group; Y represents a group --(CH.sub.2).sub.m --, wherein m represents 2, 3 or 4; or Y represents a group --X(CH.sub.2).sub.p --, wherein p represents 2 or 3, X represents an oxygen or a sulphur atom or a group NR.sup.4, where R.sup.4 is a C.sub.1-6 alkyl group, and X is attached to the benzene ring moiety of the molecule; and physiologically acceptable salts and solvates thereof.The compounds of formula (I) are potent and selective antagonists of 5-hydroxytryptamine at 5-HT.sub.Type: GrantFiled: August 31, 1989Date of Patent: March 5, 1991Assignee: Glaxo Group LimitedInventors: David E. Bays, Ian H. Coates, Alexander W. Oxford, Peter C. North
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Patent number: 4997832Abstract: Disclosed are the compounds of formula I ##STR1## wherein R.sub.1 -R.sub.3 represent hy drogen or lower alkyl; m represents the integer 2 or 3; n represents the integer 1 or 2; Het represents a pyrrole or imidazole ring bonded at any two adjacent positions and optionally substituted by one or two of lower alkyl; and pharmaceutically acceptable salts of compounds of formula I wherein Het represents optionally substituted imidazole; their methods of preparation; pharmaceutical compositions thereof, and their use for treating cognitive disorders in mammals.Type: GrantFiled: October 24, 1989Date of Patent: March 5, 1991Assignee: Ciba-Geigy CorporationInventor: Jan W. F. Wasley
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Patent number: 4985430Abstract: There are disclosed a 9-acylamino-tetrahydroacridine derivative represented by the following formula (I): ##STR1## wherein R ##STR2## are as defined in the specification, its optical antipode or pharmaceutically acceptable acid addition salt thereof and a memory enhancing agent containing the same as an active ingredient.Type: GrantFiled: December 2, 1988Date of Patent: January 15, 1991Assignee: Mitsubishi Kasei CorporationInventors: Shuji Morita, Ken-Ichi Saito, Kunihiro Ninomiya, Akihiro Tobe, Issei Nitta, Mamoru Sugano
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Patent number: 4977265Abstract: Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, X, Y, Z and n are as hereinafter described, and salts thereof, prepared starting from corresponding tricyclic compounds, are described. The compounds I and some of the said tricyclic compounds have antibacterial activity, and are therefore useful as antibacterial agents.Type: GrantFiled: May 15, 1990Date of Patent: December 11, 1990Assignee: Hoffmann-La Roche Inc.Inventors: Synese Jolidon, Rita Locher, Ivan Kompis, Ekkehard Weiss, Pierre-Charles Wyss
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Patent number: 4966971Abstract: To prepare the compound (I), a lithiation of the compound (II) is performed, an aldehyde (IV) is reacted with the compound (III) formed, leading to the secondary alcohol (V) which is subjected to a reduction leading to the compound (VI), which is then subjected to a hydrolysis (of the dioxolane group)/cyclization/dehydration reaction. The procedure may be followed by a nucleophilic substitution reaction of the chlorine. The compounds (a) below exhibit antitumor activity. ##STR1## R=C.sub.1 -C.sub.3 alkyl; Ar=aromatic or polycyclic aromatic group; R.sub.1 and r.sub.2 =H or C.sub.1 -C.sub.3 alkyl; and n=2 to 4. No drawing.Type: GrantFiled: November 14, 1988Date of Patent: October 30, 1990Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Emile R. B. Bisagni, Marilys Greletepouse Rautureau
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Patent number: 4960891Abstract: The invention provides a process for preparing compounds, as a single enantiomer or mixture of enantiomers, represented by the formula: ##STR1## in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, andZ is --SO.sub.2 R or --C(O)NR.sup.3 R.sup.4, in which;R is lower alkyl, optionally substituted phenyl, --(CH.sub.2).sub.m OR.sup.1 or --NR.sup.1 R.sup.2 wherein m is an integer of 1 to 6 and R.sup.1 and R.sup.2 are independently hydrogen or lower alkyl; andR.sup.3 and R.sup.4 are independently hydrogen, alkyl, optionally substituted phenyl or phenyl lower alkyl; orR.sup.1 and R.sup.2 taken together with the nitrogen to which they are attached or R.sup.3 and R.sup.4 taken together with the nitrogen to which they are attached represent a heterocycle of the formula: ##STR2## wherein A is --CH.sub.2 --, --NR.sup.1 -- or oxygen; and novel intermediates.Type: GrantFiled: April 11, 1989Date of Patent: October 2, 1990Assignee: Syntex (U.S.A.) Inc.Inventor: Robin D. Clark
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Patent number: 4956365Abstract: Compounds of formulas (1) and (2): ##STR1## in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy;W is oxygen or sulfur; andZ is --R.sup.1, --OR.sup.2 or --NR.sup.3 R.sup.4, whereinR.sup.1 is lower alkyl, lower haloalkyl, cycloalkyl, optionally substituted phenyl or phenyl lower alkyl, or heteroaryl;R.sup.2 is lower alkyl, optionally substituted phenyl or phenyl lower alkyl;R.sup.3 and R.sup.4 are independently hydrogen, alkyl, optionally substituted phenyl or phenyl lower alkyl; orR.sup.3 and R.sup.4 taken together with the nitrogen to which they are attached represent a heterocycle of the formula: ##STR2## wherein A is --(CH.sub.2).sub.m, --N(R.sup.5)-- or oxygen, in which m is an integer of 0-2 and R.sup.5 is hydrogen or lower alkyl;or a pharmaceutically acceptable salt thereof, are useful as .alpha..sub.2 -blockers.Type: GrantFiled: October 12, 1988Date of Patent: September 11, 1990Assignee: Syntex (U.S.A.) Inc.Inventors: Robin D. Clark, Andrew T. Kilpatrick, Michael Spedding