Hetero Ring Is Five-membered Having Two Or More Ring Hetero Atoms Of Which At Least One Is Nitrogen (e.g., Selenazoles, Etc.) Patents (Class 548/100)
  • Patent number: 10663471
    Abstract: A compound can be a pro-fluorophore peroxynitrite sensor that generates a fluorophore when cleaved by peroxynitrite, having a structure of Formula A: wherein: moiety A is an ER-targeting fluorophore; Y is a linker; and moiety B is a phenol, substituted or unsubstituted, wherein the structure of Formula A is less fluorescent than the ER-targeting fluorophore moiety A.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: May 26, 2020
    Assignee: The University of Kansas
    Inventors: Blake R. Peterson, Digamber Rane
  • Patent number: 10202408
    Abstract: The invention relates to compounds of use as targeted cytotoxic agents and methods of use thereof. In particular, the invention relates to prodrugs that are substantially resistant to human AKR1C3 enzyme metabolism, methods of cell ablation using said compounds and methods of treatment of cancer and other hyperproliferative disorders using said compounds.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: February 12, 2019
    Assignee: Health Innovation Ventures B.V.
    Inventors: Jeffrey Bruce Smaill, Adam Vorn Patterson, Amir Ashoorzadeh, Christopher Paul Guise, Alexandra Marie Mowday, David Francis Ackerley, Elsie May Williams, Janine Naomi Copp
  • Patent number: 9802907
    Abstract: A 2-aryl selenazole compound and a pharmaceutical composition are disclosed, wherein the 2-aryl selenazole compound is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The 2-aryl selenazole compound has the activity of inhibiting xanthine oxidase. The compound or a pharmaceutically acceptable salt thereof can be applied in terms of preparing a drug used for prevention or treatment of hyperuricemia, gout, diabetic nephropathy, an inflammatory disease or a neurological disease.
    Type: Grant
    Filed: November 24, 2013
    Date of Patent: October 31, 2017
    Assignee: JIANGSU ATOM BIOSCIENCE AND PHARMACEUTICAL CO., LTD.
    Inventors: Dongfang Shi, Changjin Fu, Jie Wu, Jun Liu
  • Patent number: 9266853
    Abstract: An object of the present invention is to provide a compound that is useful as an orally available anti-HCV agent. The present invention relates to a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. This compound has an anti-HCV activity and is useful as a medicine.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: February 23, 2016
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yasunori Kohchi, Kimitaka Nakama, Susumu Komiyama, Fumio Watanabe
  • Patent number: 9056887
    Abstract: Minor groove binder phosphoramidites having the formula M-L-PA, wherein M is a minor groove binder comprising a protected heteroaromatic amine, L is a linker, and PA is a phosphoramidite group, have been synthesized. Preferred methods of synthesis include synthesizing a minor groove binder intermediate containing a transiently protected hydroxyl group, protecting heteroaromatic amines of the corresponding minor groove binder intermediate as carbamate intermediates, reacting the carbamate intermediate to remove the transient protecting group to yield carbamate-protected minor groove binder agent as an intermediate with a free hydroxyl group, and converting the intermediate with a free hydroxyl group to the desired minor groove binder phosphoramidite. These minor groove binder phosphoramidites are useful in the preparation of oligonucleotide conjugates, particularly those for use as probes and primers.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: June 16, 2015
    Assignee: Elitech Holding B.V.
    Inventors: Alexei Vorobiev, Eugeny A. Lukhtanov
  • Patent number: 9040498
    Abstract: The present invention relates to novel 1,2,3-triazolyl purine derivatives. The invention also relates to using the derivatives to treat cancer and various viral infections.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: May 26, 2015
    Assignee: Research Foundation of the City University of New York
    Inventor: Mahesh K. Lakshman
  • Patent number: 9023600
    Abstract: A dinuclear zinc complex PPi sensor is provided, that may be represented by the formula where X is hydrogen, —COOEt, —CH?CH2, —OR, or —NR2, wherein X is a monovalent organic group having from 1 to about 20 carbon atoms. A method of preparing the dinuclear zinc complex PPi sensor is also provided. Methods for detecting PPi in an aqueous solution and methods for pyrosequencing by using the dinuclear zinc complex are described.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: May 5, 2015
    Assignee: The University of Akron
    Inventors: Yi Pang, Weihua Chen
  • Patent number: 8969578
    Abstract: Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R1 comprises a phenyl or naphthyl group, R2 comprises an amide group and R3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in certain tumor tissues and which promotes cellular overproliferation and resistance to apoptosis. The invention includes compositions containing the disclosed compounds, as well as methods of treatment therewith.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: March 3, 2015
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James Turkson, Andrew D. Hamilton
  • Patent number: 8933441
    Abstract: An organic electronic device may include an organic semiconductor compound represented by the following Chemical Formula 1 or Chemical Formula 2. Each substituent of the above Chemical Formulas 1 and 2 may be the same as described in the detailed description.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: January 13, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Jong Won Chung, Bang Lin Lee, Jeong Il Park, Yong Wan Jin
  • Patent number: 8907102
    Abstract: A method is provided for forming a zeolitic imidazolate framework composition using at least one reactant that is relatively insoluble in the reaction medium. Also provided herein is a material made according to the method, designated as EMM-19, and a method of using EMM-19 to adsorb gases, such as carbon dioxide.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 9, 2014
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Simon Christopher Weston, Mobae Afeworki, Zheng Ni, John Zengel, David Lawrence Stern
  • Patent number: 8884029
    Abstract: A photoelectric conversion device capable of improving conversion efficiency is provided. The photoelectric conversion device includes a work electrode, an opposed electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided. The dye contains a cyanine compound that has a methine chain, an indolenine skeleton bonded with both ends of the methine chain, and anchor groups introduced to a nitrogen atom included in the indolenine skeleton. Electron injection efficiency to the metal oxide semiconductor layer is improved, and the dye is hardly exfoliated from the metal oxide semiconductor layer.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: November 11, 2014
    Assignee: Adeka Corporation
    Inventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Mitsuhiro Okada, Toru Yano, Yohei Aoyama, Yusuke Kubota
  • Patent number: 8846726
    Abstract: The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: September 30, 2014
    Assignee: Incyte Corporation
    Inventors: Andrew P. Combs, Eddy W. Yue
  • Patent number: 8765934
    Abstract: A method for conjugating a nucleic acid with a molecule is provided. The method includes steps of (a) reacting the nucleic acid having a 5?-monophosphate with an activating agent in a first buffer to form a solution; (b) mixing an alcohol with the solution formed in the step (a) to obtain an intermediate; and (c) dissolving the intermediate in a second buffer containing an ethylenediaminetetraacetic acid (EDTA) and adding a nucleophile thereinto to react the intermediate with the nucleophile.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: July 1, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Tzu-Pin Wang, Yi-Jhang Ciou
  • Publication number: 20140179637
    Abstract: A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
    Type: Application
    Filed: December 21, 2013
    Publication date: June 26, 2014
    Applicants: The Research Foundation for The State University of New York, Northwestern University
    Inventors: Jonathan Leis, Carol Carter
  • Patent number: 8703962
    Abstract: The invention relates to compounds of formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: April 22, 2014
    Assignee: Purdue Pharma L.P.
    Inventors: Donald J. Kyle, Laykea Tafesse
  • Patent number: 8691806
    Abstract: The invention provides compounds of the formula (I) having protein kinase B inhibiting activity: Also provided are pharmaceutical compositions containing the compounds, methods for preparing the compounds and their use as anticancer agents.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: April 8, 2014
    Assignees: Astex Therapeutics Limited, The Institute of Cancer Research: Royal Cancer Hospital, Cancer Research Technology Limited
    Inventors: Valerio Berdini, Gordon Saxty, Marinus Leendert Verdonk, Steven John Woodhead, Paul Graham Wyatt, Robert George Boyle, Hannah Fiona Sore, David Winter Walker, Ian Collins, Robert Downham, Robin Arthur Ellis Carr
  • Patent number: 8685369
    Abstract: One aspect of the invention relates to complexes of a radionuclide with various heteroaryl ligands, e.g., imidazolyl and pyridyl ligands, and their use in radiopharmaceuticals for a variety of clinical diagnostic and therapeutic applications. Another aspect of the invention relates to imidazolyl and pyridyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the radionuclide complexes are also described. Another aspect of the invention relates to imidazolyl and pyridyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: April 1, 2014
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: John Babich, Kevin Maresca, James Kronauge
  • Patent number: 8664424
    Abstract: Provided is a method for preparing 2,5-dimethylphenylacetic acid, wherein p-xylene is mixed with paraformaldehyde and concentrated hydrochloric acid in a solvent of ion liquid to obtain 2,5-dimethyl benzyl chloride by the chloromethylation reaction. Then, 2,5-dimethyl benzyl chloride is introduced into a reactor with an acid binding agent and a solvent, the carbonylation and hydrolysis reaction is conducted in the presence of a catalyst to obtain 2,5-dimethylphenylacetic acid. The present process has new route, less synthesis steps, simple operation, lower cost, increased yield, and is friendly to the environment. Therefore, the method is suitable for industrial production.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: March 4, 2014
    Assignees: Lianhe Chemical Technology Co., Ltd, Jiangsu Lianhe Chemical Technology Co., Ltd.
    Inventors: Ping Wang, Xiaobin Fan, Xingjun Lin, Zhaohui He
  • Patent number: 8637496
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 28, 2014
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • Patent number: 8614168
    Abstract: The invention relates to the use of at least one compound, selected from the group consisting of tebuconazole, epoxiconazole, metconazole, cyproconazole, prothioconazole and any mixtures thereof, for increasing the resistance of plants to abiotic stress factors.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: December 24, 2013
    Assignee: Monheim
    Inventors: Jan Dittgen, Isolde Häuser-Hahn, Heinz Kehne, Stefan Lehr, Jörg Tiebes, Marco Busch
  • Patent number: 8603947
    Abstract: A description is given of (4-haloalkyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, Y, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: December 10, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Dieter Feucht, Elmar Gatzweiler, Isolde Haeuser-Hahn, Christopher Hugh Rosinger
  • Patent number: 8598365
    Abstract: Bicyclic dione compounds, and derivatives thereof, which are suitable for use as herbicides.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: December 3, 2013
    Assignee: Syngenta Limited
    Inventors: Stephane André Marie Jeanmart, Christopher John Mathews, John Benjamin Taylor, Steve Smith
  • Patent number: 8592463
    Abstract: Heterocyclic compounds that modulate the hedgehog signaling pathway, pharmaceutical composition thereof and their therapeutic applications.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: November 26, 2013
    Assignee: Siena Biotech S.p.A.
    Inventors: Russell John Thomas, Gal.la Pericot Mohr, Giacomo Minetto, Annette Cornelia Bakker, Pietro Ferruzzi
  • Patent number: 8563779
    Abstract: A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: October 22, 2013
    Assignee: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Andreas Van Almsick, Elmar Gatzweiler, Dieter Feucht, Isolde Haeuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
  • Patent number: 8551426
    Abstract: Provided are an RNase activity inhibitory compound to effectively control the activity of the RNase promoting degradation of extracted RNAs and, in addition, a sample storage container including the same. The RNase activity inhibitory compound and the sample storage container according to the present invention may be effectively used to store RNAs during RNA extraction or the extracted RNAs.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: October 8, 2013
    Assignee: Bioneer Corporation
    Inventors: Jong Hoon Kim, Hwangseo Park, Han Oh Park
  • Patent number: 8541594
    Abstract: Bicyclic dione compounds, and derivatives thereof, which are suitable for use as herbicides.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: September 24, 2013
    Assignee: Syngenta Limited
    Inventors: Stephane André Marie Jeanmart, Christopher John Mathews, John Benjamin Taylor, Steve Smith
  • Patent number: 8530667
    Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: September 1, 2008
    Date of Patent: September 10, 2013
    Assignee: Syngenta Limited
    Inventors: Stephane André Marie Jeanmart, John Benjamin Taylor, Melloney Tyte, Christopher John Mathews, Stephen Christopher Smith
  • Publication number: 20130231604
    Abstract: Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.
    Type: Application
    Filed: March 3, 2012
    Publication date: September 5, 2013
    Applicant: NANOQUANTUM SCIENCES, INC.
    Inventors: Gary W. Jones, Anatoliy L. Tatarets, Leonid D. Patsenker
  • Patent number: 8524936
    Abstract: The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as oral anti-diabetic drug. Starting from L-aspartic acid derivate of formula IV the invention describes preparation of the chiral (R)-?-amino acid of formula II known as a precursor in the synthesis of Sitagliptin (formula I).
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: September 3, 2013
    Inventor: Milan Soukup
  • Publication number: 20130184465
    Abstract: The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
    Type: Application
    Filed: September 27, 2011
    Publication date: July 18, 2013
    Applicant: BASF SE
    Inventors: Maximilian Dochnahl, Michael Keil, Joachim Gebhardt, Uwe Josef Vogelbacher, Michael Rack
  • Patent number: 8410282
    Abstract: This compounds correspond to the formula (I), where: R1 represents and aryl or heteroaryl group optionally substituted by one or more substituents selected from the group consisting of halogen atoms, straight or branched optionally substituted lower alkyl, cycloalkyl, hydroxy, straight or branched, optionally substituted lower alkoxy, cyano, or —CO2R?, wherein R? represents a hydrogen atom or a straight or branched, optionally substituted lower alkyl group; R2 represents a group selected from: a) a straight or branched lower alkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms; b) a cycloalkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms; c) a straight or branched alkylcycloalkyl or cycloalkylalkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms. Formula (I).
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: April 2, 2013
    Assignee: Palobiofarma, S.L.
    Inventors: Lyhen Gonzalez Lio, Juan Alberto Camacho Gomez
  • Patent number: 8410084
    Abstract: This invention relates to novel macromolecular compositions having oxidation inhibition characteristics that are exhibited when added to organic material normally susceptible to oxidative degradation in the presence of air or oxygen, such a petroleum products, synthetic polymers, and elastomeric substances.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: April 2, 2013
    Assignee: Albemarle Corporation
    Inventors: Mahmood Sabahi, Vincent J. Gatto, Hassan Y. Elnagar
  • Patent number: 8372870
    Abstract: The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: February 12, 2013
    Assignee: Incyte Corporation
    Inventors: Andrew P. Combs, Eddy W. Yue
  • Publication number: 20130005963
    Abstract: An organic photoelectric conversion material for use in an organic thin-film photoelectric conversion device, containing a compound represented by formula 1; and an organic thin-film photoelectric conversion device having a photoelectric conversion layer which containing the organic photoelectric conversion material: wherein D represents an electron-donating aromatic substituent whose bonding site atom is a sp2 carbon atom; and a plurality of D may be the same or different from each other.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 3, 2013
    Applicant: FUJIFILM CORPORATION
    Inventor: Tetsu KITAMURA
  • Patent number: 8343913
    Abstract: A method of reducing antifungal drug resistance in which Hsp inhibitors, such as Hsp90 inhibitors, are used.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: January 1, 2013
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Leah Cowen, Susan L. Lindquist
  • Patent number: 8343638
    Abstract: An organic light emitting diode is disclosed, and includes a light-efficiency-improvement layer containing a compound represented by Formula 1:
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: January 1, 2013
    Assignee: Samsung Display Co., Ltd.
    Inventors: Seung-Gak Yang, Hee-Yeon Kim, Jae-Yong Lee, Jong-Hyuk Lee
  • Patent number: 8338466
    Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: December 25, 2012
    Assignee: Abbott Laboratories
    Inventors: Aaron R. Kunzer, Steven W. Elmore, Laura A. Hexamer, Cheol-Min Park, Andrew J. Souers, Gerard M. Sullivan, Gary T. Wang, Xilu Wang, Michael D. Wendt
  • Publication number: 20120316346
    Abstract: Provided are a novel selenazole derivative which activates peroxisome proliferator-activated receptor (PPAR), a hydrate thereof, a solvate thereof, a stereoisomer thereof and a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition, a cosmetic composition, a functional food composition, a functional drink composition and an animal feed composition containing the same.
    Type: Application
    Filed: February 25, 2010
    Publication date: December 13, 2012
    Applicant: SNU R & DB FOUNDATION
    Inventors: Heonjoong Kang, Jungwook Chin, Jaehwan Lee
  • Patent number: 8329913
    Abstract: An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: December 11, 2012
    Assignee: Zeria Pharmaceutical Co., Ltd.
    Inventors: Masakazu Murata, Yoshihiko Itokazu, Ryu Nakao
  • Patent number: 8318948
    Abstract: Disclosed is a novel fluorene derivative and an organic electronic device using the same. The organic electronic device has excellent efficiency, driving voltage, and a lifespan.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: November 27, 2012
    Assignee: LG Chem, Ltd.
    Inventors: Jae-Soon Bae, Dong-Hoon Lee, Dae-Woong Lee, Sung-Kil Hong, Hyun Nam, Chang-Hwan Kim
  • Patent number: 8318760
    Abstract: Substituted aryl and heteroaryl derivatives are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: November 27, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John E. Stelmach, Keith G. Rosauer, Emma R. Parmee, James R. Tata
  • Patent number: 8288449
    Abstract: Latent photoactivatable precatalysts are provided for metathesis polymerization and has the general formula (Ru(NHC)n(X1)m(L)0p+((X2)?)p. Wherein NHC is an N-heterocyclic carbene, n=1 or 2; X1 is a C1-C18 mono or polyhalogenized carbolic acid or trifluoromethane sulfate; X2 is a C1-C18 mono or polyhalogenized carbolic acid, trifluoromethane sulfate, tetrafluoroborate, hexafluorophosphate, or hexafluoroantimonate; m=0, 1, or 2 and L=a C4-C18 carbolic acid nitrile or a C4-C18 carbolic acid di or trinitrile; o=6?n?m or 5?n?m and p=2?m.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: October 16, 2012
    Assignee: Deutsche Institute fuer Textil- und Faserforschung Denkendorf
    Inventors: Michael R. Buchmeiser, Dongren Wang
  • Patent number: 8247576
    Abstract: The invention provides compounds of the formula: (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom a with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom a with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R1 is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: August 21, 2012
    Assignees: Astex Therapeutics Limited, Institute of Cancer Research: Royal Cancer Hospital, Cancer Research Technology Limited
    Inventors: Valerio Berdini, Gordon Saxty, Marinus Leendert Verdonk, Steven John Woodhead, Paul Graham Wyatt, Robert George Boyle, Hannah Fiona Sore, David Winter Walker, Ian Collins, Robert Downham, Robin Arthur Ellis Carr
  • Patent number: 8188292
    Abstract: N-Substituted (heteroaryl)alkyl sulfilimines are effective at controlling insects.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: May 29, 2012
    Assignee: Dow AgroSciences, LLC
    Inventors: Michael R. Loso, Benjamin M. Nugent, Yuanming Zhu, Richard B. Rogers, Jim X. Huang, James M. Renga, Zoltan L. Benko, Gregory T. Whiteker, John F. Daeuble, Sr.
  • Patent number: 8168327
    Abstract: An imide derivative represented by the following formula (A): wherein Ra and Rb are each a hydrogen atom, a halogen atom, a cyano group, an alkyl group, a fluoroalkyl group or an aryl group; at least one of Ra and Rb is a fluoroalkyl group; and Rc and Rd are each a substituted or unsubstituted benzyl group, an aryl group, a heterocycle, a fluoroalkyl group or an imide group.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: May 1, 2012
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Hironobu Morishita, Hisayuki Kawamura, Chishio Hosokawa
  • Patent number: 8157950
    Abstract: Aldimines of Formula (I), which can be used as latent curing agents in curing compositions, for example, in moisture-curing polyurethane compositions that have isocyanate groups. The aldimines are compounds that can be liquid at room temperature, can have a hardly noticeable aldehyde odor before, during and after hydrolysis, and can have a long shelf life. An aldehyde in polyurethane compositions that is released during hydrolysis has only a slight softening effect and can exhibit very little tendency to migrate or exude.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: April 17, 2012
    Assignee: Sika Technology AG
    Inventor: Urs Burckhardt
  • Patent number: 8148490
    Abstract: The present invention is directed to a method for preparing a cyclic guanidine comprising reacting (i) a guanidinium, (ii) a polyamine, and (iii) a weak acid. The present invention is also directed to a coating composition comprising the cyclic guanidine.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: April 3, 2012
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Gregory J. McCollum, Charles R. Hickenboth, Richard F. Karabin, Thomas C. Moriarity, Steven R. Zawacky
  • Publication number: 20120071516
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Application
    Filed: September 22, 2011
    Publication date: March 22, 2012
    Applicant: CalciMedica, Inc.
    Inventors: Jianguo Cao, Jeffrey P. Whitten, Yazhong Pei, Zhijun Wang, Evan Rogers, Jonathan Grey
  • Patent number: 8134146
    Abstract: The present invention relates to heterocyclic radicals or diradicals, the dimers, oligomers, polymers, dispiro compounds and polycycles thereof, to the use thereof to organic semiconductive materials and to electronic and optoelectronic components.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: March 13, 2012
    Assignee: Novaled AG
    Inventors: Michael Limmert, Olaf Zeika, Martin Ammann, Horst Hartmann, Ansgar Werner
  • Publication number: 20120040826
    Abstract: Bicyclic dione compounds, and derivatives thereof, which are suitable for use as herbicides.
    Type: Application
    Filed: July 30, 2008
    Publication date: February 16, 2012
    Applicant: SYNGENTA LIMITED
    Inventors: Stephane André Marie Jeanmart, Christopher John Mathews, John Benjamin Taylor, Steve Smith