Plural Polycyclo Ring Systems Having The Oxazole Ring As One Of The Cyclos In Each Of The Ring Systems Patents (Class 548/219)
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Organometalic compounds for electroluminescence and organic electroluminescent device using the same
Publication number: 20090078317Abstract: The present invention relates to electroluminescent compounds represented by Chemical Formula (1) L1L1M(Q)m and electroluminescent devices comprising the same as host material. The electroluminescent compound according to the invention, when used as host material of an OLED, noticeably lowers the operation voltage and enhance the power efficiency.Type: ApplicationFiled: September 5, 2008Publication date: March 26, 2009Applicant: Gracel Display Inc.Inventors: Hyun Kim, Young Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon -
Patent number: 7449478Abstract: This invention relates to treating peroxisome proliferator-activated receptors related diseases with certain indole compounds. The indole compounds are of formula (I) below. Each variable is defined in the specification.Type: GrantFiled: December 3, 2004Date of Patent: November 11, 2008Assignee: National Health Research InstitutesInventors: Hsing-Pang Hsieh, Neeraj Mahindroo, Tsu-An Hsu, Chien-Fu Huang, Xin Chen, Yu-Sheng Chao
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Publication number: 20080275224Abstract: The present invention relates to dyes of the general formula CAT+ Y? (I), where Y? is an anion selected from the group of the cyanoborates, fluoroalkylphosphates, fluoroalkylborates or imidates and CAT+ is a cation selected from the group of the azine, xanthene, polymethine, styryl, azo, tetrazolium, pyrylium, benzopyrylium, thiopyrylium, benzothiopyrylium, thiazine, oxazine, triarylmethane, diarylmethane, methine, acridine, quinoline, isoquinoline or quaternary azafluorenone dyes, for colouring plastics and plastic fibres, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp ink, for colouring leather and paper, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry.Type: ApplicationFiled: July 22, 2004Publication date: November 6, 2008Inventors: Nikolai (Mykola) Ignatyev, Urs Weiz-Biermann, Helge Willner, Maik Finze, Eduard Bernhardt, Andriy Kucheryna
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Patent number: 7402671Abstract: Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted from the donor dye. One of the energy transfer dyes has a donor dye which is a member of a class of dyes having a coumarin or pyrene ring structure and an acceptor dye which is capable of absorbing energy emitted from the donor dye, wherein the donor dye has an absorption maxima between about 250 and 450 nm and the acceptor dye has an emission maxima at a wavelength greater than about 500 nm.Type: GrantFiled: March 10, 2006Date of Patent: July 22, 2008Assignee: Applera CorporationInventor: Linda G. Lee
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Publication number: 20080064880Abstract: Compounds that absorb ultraviolet light 380 nm to 400 nm range but avoid absorption in the blue light range, thereby imparting yellowness, i.e., 410-420 nm have suitable refractive characteristics useful in the preparation of optical resins or plastics suitable, for example, for the manufacture of ophthalmic lenses. Methods for making the compounds, optic lenses containing the compounds, and methods for making these are also described.Type: ApplicationFiled: December 30, 2005Publication date: March 13, 2008Applicant: Essilor International Compagnie Generale d' OptiqueInventors: Joel M. Kauffman, Peter T. Litak, Martin Rickwood
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Patent number: 7307095Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: GrantFiled: January 5, 2007Date of Patent: December 11, 2007Assignee: IRM LLCInventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
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Patent number: 7235320Abstract: The present invention relates to a novel proton-conducting polymer membrane based on polyazoles which can, because of its excellent chemical and thermal properties, be used in a variety of ways and is particularly useful as polymer electrolyte membrane (PEM) to produce membrane electrode units for PEM fuel cells.Type: GrantFiled: April 9, 2002Date of Patent: June 26, 2007Assignee: PEMEAS GmbHInventors: Gordon Calundann, Michael J. Sansone, Oemer Uensal, Joachim Kiefer
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Patent number: 7173051Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.Type: GrantFiled: June 10, 2004Date of Patent: February 6, 2007Assignee: IRM, LLCInventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
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Patent number: 7172907Abstract: Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1): in which groups R3 and R4 are attached to the Z1 ring structure and groups R5 and R6 are attached to the Z2 ring structure, and n=1, 2 or 3; Z1 and Z2 independently represent the atoms necessary to complete one ring, or two fused ring aromatic or heteroaromatic systems, each ring having five or six atoms selected from carbon atoms and optionally no more than two atoms selected from oxygen, nitrogen and sulphur; X and Y are the same or different and are selected from oxygen, sulphur, —CH?CH— and the group: at least one of groups R1, R2, R3, R4, R5, R6 (and R8 and R9 if present) is the group -E-F where E is a spacer group and F is a target bonding group; one of groups R7 is selected from —CN, —Cl, —F, —CF3 and —C(O)R10 wherein R10 is selected from H, C1–C6 alkyl and aryl.Type: GrantFiled: March 21, 2003Date of Patent: February 6, 2007Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Chung-Yuan Chen, Shiv Kumar
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Patent number: 7019020Abstract: Novel benzoxazolyl benzene derivatives of formula (I): wherein R1 is hydrogen, C1-20-alkyl or C2-20-alkenyl; R2 and R3 are independently a group —C(R4,R5)C(R6)?C(R7,R8) (a) or a group —C(R4?,R5?)CH(R6?)CH(R7?,R8?) (b), wherein R4, R5, R6, R7, R8, R4?, R5?, R6?, R7? and R8? are independently, hydrogen, C1-10-alkyl or C2-10-alkenyl, or C2-10-alkyl or C3-10-alkenyl containing at least one oxygen atom interrupting the hydrocarbon chain; or wherein R4, R5, R6, R4?, R5? and R6? are hydrogen, C1-10-alkyl or C2-10-alkyl containing at least one oxygen atom interrupting the hydrocarbon chain, or alkyl substituted by silane or oligosiloxane moiety, and one of R7 and R8 or R7? and R8? is a silane or oligosiloxane moiety and the other one of R7 and R8 or R7? and R8? is hydrogen; and X is phenylene or naphthylene, or substituted phenylene or naphthylene for use as UV screening agents for protecting human skin or hair against radiation, and in UV screening compositions, particularly topical compositions for cosmentic orType: GrantFiled: January 28, 2002Date of Patent: March 28, 2006Assignee: DSM IP Assets B.V.Inventor: Ulrich Huber
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Patent number: 7012141Abstract: Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted from the donor dye. One of the energy transfer dyes has a donor dye which is a member of a class of dyes having a coumarin or pyrene ring structure and an acceptor dye which is capable of absorbing energy emitted from the donor dye, wherein the donor dye has an absorption maxima between about 250 and 450 nm and the acceptor dye has an emission maxima at a wave length greater than about 500 nm.Type: GrantFiled: February 7, 2003Date of Patent: March 14, 2006Assignee: Applera CorporationInventor: Linda G. Lee
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Patent number: 6884891Abstract: Methine dye compounds represented by formula (1) and highly sensitive silver halide photographic materials containing these compounds: Dye1-(L1-(Dye2)m1)m2 (CI1)y1??(1) wherein L1 represents a linkage group represented by formula (2), m1 represents an integer of 1 to 5, m2 represents an integer of 1 to 5, Dye1 represents a first chromophore, Dye 2 represents a second chromophore, CI1 represents an ion for neutralization of electric charge, and y1 represents a number of the ions required for neutralization of electric charges; -G1-A1-Y1-G2-Y2-A2-G3-??(2) wherein A1 and A2 each individually represent a carbonyl group or a sulfonyl group, Y1 and Y2 each individually represent —O—, —S— or —NR1—, R1 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or a heterocyclic group, and G1, G2 and G3 each individually represent a divalent linkage group.Type: GrantFiled: July 11, 2002Date of Patent: April 26, 2005Assignee: Fuji Photo Film Co., Ltd.Inventor: Katsumi Kobayashi
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Publication number: 20040260072Abstract: This invention relates to new fluorescence dyes from the class of cyanine dyes, especially indotricarbocyanines with an absorption and fluorescence maximum in the spectral range of 700 to 900 nm, a thiol-specific reactive group, and three, preferably four, sulfonate groups, to an increase of water solubility as well as the production of dyes. This invention also relates to the conjugates of these dyes with biomolecules and uses thereof.Type: ApplicationFiled: January 23, 2004Publication date: December 23, 2004Inventors: Kai Licha, Christin Perlitz
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Patent number: 6743785Abstract: The present invention provides selective kinase inhibitors of formula (I).Type: GrantFiled: May 21, 2002Date of Patent: June 1, 2004Assignee: Eli Lilly and CompanyInventors: Rima Salim Al-Awar, Kyle Andrew Hecker, Jianping Huang, Sajan Joseph, James Edward Ray, Philip Parker Waid
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Patent number: 6737532Abstract: An organic electroluminescent compound of the formula (I) wherein: X1 is selected from the group consisting of oxygen, sulfur, C(CH3)2 and N—R, wherein R is hydrogen, alkyl of from 1 to 20 carbon atoms or aryl; and Ar1 and Ar2 are individually aryl or heterocyclic systems. Applying the compound to an electroluminescent (EL) device provides a highly efficient blue and green emitting organic EL device.Type: GrantFiled: April 5, 2002Date of Patent: May 18, 2004Assignees: Chi Mei Optoelectronics Corporation, Kyocera CorporationInventors: Ruey-Min Chen, Jun-Wen Chung
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Publication number: 20030232997Abstract: A powder paint binder composition is useful for the preparation of a powder paint composition which includes, as crosslinking agent, an aromatic bisoxazoline obtained by reacting an aromatic carboxylic acid or an ester thereof with an alkanolamine to obtain an hydroxylamide. The hydroxyalkylamide is converted into an aromatic bisoxazoline in the presence of a catalyst. The catalyst includes phosphinic acid, (C1-C26) alkyl phosphinic acid, (C6-C20) aryl phosphinic acid or an ester or an anhydride derived from one of these acids. Powder paint compositions including the powder paint binder composition form coatings by curing the powder paint. The aromatic bisoxazlines are also useful as chain-extending agents for polymers such as polyamides and polyesters.Type: ApplicationFiled: June 24, 2003Publication date: December 18, 2003Inventors: Rudolfus A.T.M. Van Benthem, Jacobus A. Loontjens, Patrick H.M. Hendriks, Bartholomeus J.M. Plum
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Publication number: 20030180221Abstract: A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.Type: ApplicationFiled: December 20, 2002Publication date: September 25, 2003Applicant: Schering AGInventors: Naoto Miwa, Michihito Inagaki, Hiroaki Eguchi, Masafumi Okumura, Yoshio Inagaki, Toru Harada
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Publication number: 20030175629Abstract: A process for preparing a concentrated photographic spectral sensitizing dye-water composition which comprises adding an anionic sensitizing dye to an aqueous medium in the substantial absence of organic solvent, and agitating the combined dye and aqueous medium, wherein the anionic dye forms a liquid-crystalline dye phase in the aqueous medium and the agitation is performed in the presence of a nonionic surfactant having an HLB of less than 12 and an aqueous solubility at 25° C. of greater than 10 ppm, which nonionic surfactant is in the aqueous medium at a level of from 10 to 1000 ppm. In a specific embodiment of the invention, where the viscosity (at 0.1 s−1 shear rate) of the dye-water composition in the absence of the nonionic surfactant would be greater than 100 cp and especially where such viscosity would be greater than 500 cp, the surfactant is preferably present at a level sufficient to substantially reduce air entrainment during agitation of the dye-water composition.Type: ApplicationFiled: January 28, 2002Publication date: September 18, 2003Applicant: Eastman Kodak CompanyInventors: James E. Novak, Jeffrey S. Baugher, Dirk J. Hasberg, Lloyd A. Lobo
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Publication number: 20030134237Abstract: Methine dye compounds represented by formula (1) and highly sensitive silver halide photographic materials containing these compounds:Type: ApplicationFiled: July 11, 2002Publication date: July 17, 2003Applicant: FUJI PHOTO FILM CO., LTD.Inventor: Katsumi Kobayashi
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Patent number: 6461747Abstract: Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L&Parenopenst;A)m (I) wherein A represents a heterocyclic group in which two or more aromatic heterocycles are condensed; m represents an integer of 2 or more, and the heterocyclic groups represented by A may be the same or different; and L represents a connecting group.Type: GrantFiled: July 21, 2000Date of Patent: October 8, 2002Assignee: Fuji Photo Co., Ltd.Inventors: Hisashi Okada, Toshihiro Ise
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Publication number: 20020127502Abstract: A heterocyclic compound corresponding to formula (I) 1Type: ApplicationFiled: November 5, 2001Publication date: September 12, 2002Inventor: Michael Missfeldt
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Patent number: 6437141Abstract: A cyanine dye having the formula wherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.Type: GrantFiled: April 2, 2001Date of Patent: August 20, 2002Assignee: NEN Life Science Products, Inc.Inventors: Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow
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Patent number: 6403807Abstract: Bridged fluorescent dyes of the cyanine and squaraine families are disclosed. The dyes are useful as markers in assay techniques and offer advantages of undergoing excitation at a common wavelength but emitting at structure dependent different wavelengths.Type: GrantFiled: July 6, 2000Date of Patent: June 11, 2002Assignee: SurroMed, Inc.Inventors: Rajendra Singh, Gregory Gorski, Gary Frenzel
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Patent number: 6224644Abstract: A cyanine dye having the formula wherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.Type: GrantFiled: November 24, 1999Date of Patent: May 1, 2001Assignee: NEN Life Science Products, Inc.Inventors: Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow
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Patent number: 6204389Abstract: A cyanine dye having the formula wherein R1--R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.Type: GrantFiled: November 24, 1999Date of Patent: March 20, 2001Assignee: NEN Life Science Products, Inc.Inventors: Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow
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Patent number: 6197956Abstract: A cyanine dye having the formula wherein R1-R8 are each independently selected from a group consisting of hydrogen, C1-C6 alkyl group, and C0-C4 alkyl group having a hydrophilic substituent thereon. R11 and R12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.Type: GrantFiled: November 24, 1999Date of Patent: March 6, 2001Assignee: NEN Life Science Products, Inc.Inventors: Malcolm Harry Randall, Philip Richard Buzby, Thomas Joseph Erickson, Joseph David Trometer, Joseph John Miller, Jr., David George Ahern, Mark Norman Bobrow
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Patent number: 6177574Abstract: Disclosed is a process for the preparation of a mixture of benzoxazolyl-stilbene compounds by the reaction of unsubstituted 4,4′-bis(benzoxazol-2-yl)stilbene with a substituted o-aminophenol or o-aminonaphthol to obtain a mixture comprising the unsubstituted 4,4′-bis(benzoxazol-2-yl)stilbene and at least one substituted 4,4′-bis(benzoxazol-2-yl)stilbene, 4-naphthoxazol-2-yl-4′-benzoxazol-2-ylstilbene and/or 4,4′-bis(naphthoxazol-2-yl)stilbene. These mixtures are useful as fluorescent brightening agents and light stabilizers for synthetic polymeric materials such as polyesters, polyamide and polyolefin textile materials and shaped articles.Type: GrantFiled: March 2, 2000Date of Patent: January 23, 2001Assignee: Eastman Chemical CompanyInventor: Kim Steven Chamberlin
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Patent number: 6140051Abstract: Dibenzazole compounds having the general structure: ##STR1## wherein; R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 are independently H or a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety; Y is H or a cleavable moiety; X is a hydrogen, halogen, CF.sub.3, or SO.sub.3 H; V and W are oxygen or sulfur; Z is --C.dbd.C--, --C.tbd.C-- or an aromatic ring moiety; and n is 0, 1, or 2. When n=0 at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 is a substituent which aids in solubility of the compound or which provides a linker arm for linking the compound to another moiety or X is a halogen, CF.sub.3 or SO.sub.3 H. These compounds are highly fluorescent and can be easily detected using a fluorometer. Derivatives in which the Y group is a substituent other than H contain a fluorescence inhibiting chemical moiety that upon removal restores the fluorescence of the compound.Type: GrantFiled: July 17, 1998Date of Patent: October 31, 2000Assignee: Promega Biosciences, Inc.Inventors: Lauren R. Brown, Cheng Xu
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Patent number: 6046212Abstract: This invention relates to chalcone derivatives represented by the following formula (1): wherein A represents a phenyl group, a quinolyl group or the like, W represents a vinylene group or the like, and R.sup.1 to R.sup.5 each independently represent a carboxyl, cyano, alkyloxycarbonyl or like group, or salts of the chalcone derivatives, and also to drugs containing them as effective ingredients. These compounds have excellent cys-LT receptor antagonism, and are useful as antiallergic agents or the like.Type: GrantFiled: November 17, 1998Date of Patent: April 4, 2000Assignee: Kowa Co., Ltd.Inventors: Maria Elizabeth Zwaagstra, Mingqiang Zhang, Henk Timmerman, Kazuhiro Onogi, Masahiro Tamura, Tsutomu Toma, Yasushi Wada
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Patent number: 6004536Abstract: The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or polysulfophenyl substituents or combinations thereof. The dyes of the invention are useful for staining membranes in cells or isolated from cells, and are well-retained therein. Additionally, the reactive dyes of the invention are useful for preparing dye-conjugates, thereby conferring the membrane staining ability of the subject dye onto the resulting dye-conjugate.Type: GrantFiled: August 14, 1996Date of Patent: December 21, 1999Assignee: Molecular Probes, Inc.Inventors: Wai-Yee Leung, Richard P. Haugland, Fei Mao
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Patent number: 5998626Abstract: Disclosed are bisbenzazole compounds capable of emitting strong fluorescence, with the compounds having at particular positions specific substituent groups, such as alkoxy, aryloxy, dialkylamino, diarylamino or N-arylamino groups, to ensure high stability in organic photoluminescence elements. For example, bisbenzazole compounds show below are disclosed.Type: GrantFiled: January 27, 1999Date of Patent: December 7, 1999Assignee: Fuji Photo Film Co., Ltd.Inventor: Tadahisa Sato
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Patent number: 5880287Abstract: Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy. Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine. The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.Type: GrantFiled: June 7, 1995Date of Patent: March 9, 1999Assignee: Hyperion, Inc.Inventors: Walter B. Dandliker, Robert Francis Devlin, Peter Olaf Gustaf Arrhenius, Mao-Lin Hsu
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Patent number: 5854263Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: December 29, 1998Assignee: Hoechst Marion Roussel, Inc.Inventors: Edward J. Glamkowski, Yulin Chiang
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Patent number: 5846666Abstract: An electroluminescent device comprised of a metal thioxinoid of the formula ##STR1## wherein M represents a metal; each n is a number of from 1 to 3; N is nitrogen, S is sulfur, and Z represents an aromatic moiety.Type: GrantFiled: February 27, 1997Date of Patent: December 8, 1998Assignee: Xerox CorporationInventors: Nan-Xing Hu, Shuang Xie, Beng S. Ong, Zoran D. Popovic, Ah-Mee Hor
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Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
Patent number: 5843968Abstract: Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R.sup.3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH.dbd.N--O--A--COM, (c) CH.sub.2 --O--N.dbd.A--COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.6, (c) --NR.sup.7 R.sup.8, (d) --NR.sup.6 SO.sub.2 R.sup.Type: GrantFiled: October 27, 1997Date of Patent: December 1, 1998Assignee: Abbott LaboratoriesInventors: Clint D. W. Brooks, Pramila Bhatia, Teodozyj Kolasa, Andrew O. Stewart, David E. Gunn, Richard A. Craig -
Patent number: 5783586Abstract: Compounds having the formula: ##STR1## wherein W.sup.1 and W.sup.2 are independently selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted naphthyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R.sup.3 is selected from thienyl, furyl, phenyl, naphthyl, benzo?b!thienyl, alkyl, hydroxyl, and hydrogen; Y an alkylene of one to six carbon atoms; and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.4, (c) --NR.sup.5 R.sup.6, (d)--NR.sup.4 SO.sub.2 R.sup.7 (e)--NH--Tetrazolyl, and (f) glycinyl; inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states. Also disclosed are leukotriene biosynthesis inhibiting compositions and a method of inhibiting leukotriene biosynthesis.Type: GrantFiled: October 1, 1996Date of Patent: July 21, 1998Assignee: Abbott LaboratoriesInventors: Teodozyj Kolasa, Clint D. W. Brooks, David E. Gunn
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Patent number: 5670651Abstract: Benzocyclobutene-terminated monomers of the formula ##STR1## wherein Ar is --SO.sub.2 --, --CO--, or ##STR2## are prepared by reacting a benzocyclobutene of the formula ##STR3## wherein R is --H or --SiMe.sub.3, with a difluorophenyl compound of the formula ##STR4## wherein Ar is as described previously, in the presence of a promoter. A mixture of the resins is obtained when potassium carbonate is employed as the promoter. The bis(benzocyclobutene)-terminated monomer is obtained when cesium fluoride is employed as the promoter.Type: GrantFiled: February 12, 1996Date of Patent: September 23, 1997Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Loon-Seng Tan, Narayanan Venkatasubramanian
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Patent number: 5667764Abstract: Compounds are provided having the capability of binding therapeutically active substances to lipid containing bio-compatible particles, such as cells or viruses. These compounds include a bio-affecting moiety, comprising a therapeutically active substance, which is linked via a linking moiety to at least one hydrocarbon substituent selected so that the compounds is sufficiently non-polar to impart lipid binding capability to the compound. Thus, compounds of the invention are useful for site-selective delivery of therapeutic agents, and retention thereof at the selected site.Methods are provided for using various compounds of the invention in treatment of diseases or other pathological conditions. For example, methods are provided for treatment of: (1) post-angioplasty restenosis; (2) rheumatoid arthritis; (3) tumor cell proliferation, particularly tumor cells associated with ovarian cancer; and (4) psoriasis.Type: GrantFiled: May 15, 1992Date of Patent: September 16, 1997Assignee: Zynaxis, Inc.Inventors: Gregory A. Kopia, Paul K. Horan, Brian D. Gray, David E. Troutner, Katharine A. Muirhead, Kamleshkumar A. Sheth, Chia-En Lin, Zhizhou Yu, Bruce D. Jensen, Sue Ellen Slezak
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Patent number: 5663449Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: September 2, 1997Assignee: Hoechst Marion Roussel, Inc.Inventor: Joseph T. Strupczewski
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Patent number: 5658911Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: September 20, 1994Date of Patent: August 19, 1997Assignee: Hoechst Marion Roussel, Inc.Inventors: Joseph T. Strupczewski, Kenneth J. Bordeau, Edward J. Glamkowski, Yulin Chiang, Grover C. Helsley
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Patent number: 5654319Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: August 5, 1997Assignee: Hoechst Marion Roussel, Inc.Inventors: Edward J. Glamkowski, Yulin Chiang
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Patent number: 5639764Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: June 17, 1997Assignee: Hoechst-Marion-Roussel, Inc.Inventors: Edward J. Glamkowski, Yulin Chiang
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Patent number: 5637710Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: December 22, 1995Date of Patent: June 10, 1997Assignee: Hoechst Marion Roussel, Inc.Inventors: Joseph T. Strupczewski, Kenneth J. Bordeau
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Patent number: 5633265Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: May 27, 1997Assignee: Hoechst Marion Roussel, Inc.Inventors: Joseph T. Strupczewski, Grover C. Helsley, Edward J. Glamkowski, Yulin Chiang, Kenneth J. Bordeau, Peter A. Nemoto, John J. Tegeler
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Patent number: 5629326Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: May 13, 1997Assignee: Hoechst-Marion-Roussel, Inc.Inventors: Joseph T. Strupczewski, Grover C. Helsley, Edward J. Glamkowski, Yulin Chiang, Kenneth J. Bordeau, Peter A. Nemoto, John J. Tegeler
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Patent number: 5624927Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: April 29, 1997Assignee: Hoechst Marion Roussel, Inc.Inventors: Edward J. Glamkowski, Yulin Chiang
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Patent number: 5614543Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: March 25, 1997Assignee: Hoechst Marion Roussel, Inc.Inventors: Joseph T. Strupczewski, Kenneth J. Bordeau, Edward J. Glamkowski, Yulin Chiang, Grover C. Helsley
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Patent number: 5605913Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: June 6, 1995Date of Patent: February 25, 1997Assignee: Hoechst Roussel Pharmaceuticals, Inc.Inventors: Joseph T. Strupczewski, Yulin Chiang, Edward J. Glamkowski, Kenneth J. Bordeau, Grover C. Helsley
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Patent number: RE37029Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: November 5, 1998Date of Patent: January 23, 2001Assignee: Aventis Pharmaceuticals Inc.Inventors: Joseph T. Strupczewski, Edward J. Glamkowski, Yulin Chiang, Kenneth J. Bordeau, Peter A. Nemoto, John J. Tegler
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Patent number: RE39265Abstract: Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.Type: GrantFiled: November 9, 2000Date of Patent: September 5, 2006Assignee: Aventis Pharmaceuticals Inc.Inventors: Joseph T. Strupczewski, Kenneth J. Bordeau, Edward J. Glamkowski, Yulin Chiang, Grover C. Helsley