Benzene Ring Bonded Directly To The Triazole Ring Patents (Class 548/269.4)
  • Patent number: 9108932
    Abstract: The invention in this document is related to the field of preparation of haloalkoxyarylhydrazines and certain intermediates derived therefrom, where said intermediates are useful in the preparation of certain pesticides disclosed in U.S. Pat. No. 8,178,658.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: August 18, 2015
    Assignee: Dow AgroSciences LLC
    Inventors: Ronald Ross, Jr., Gary Roth
  • Patent number: 9054320
    Abstract: The invention provides a 1,2,4-triazole-based derivative, a production process and use thereof, and an organic electroluminescent device. The invention belongs to the technical field of organic electroluminescence, and can give a blue light-emitting material having a higher luminescence efficiency. The 1,2,4-triazole-based derivative has a molecular structure of the following general formula, wherein A group represents an aromatic heterocyclic group having a carbon atom number of 8-18, a fused-ring aromatic group having a carbon atom number of 9-15, a fluorenyl group, or a triarylamino group. The 1,2,4-triazole-based derivative mentioned in the invention can be used in organic electroluminescent device.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: June 9, 2015
    Assignees: BOE Technology Group Co., Ltd., JiLin OLED Material Tech. Co., Ltd.
    Inventors: Na Li, Yansong Li, Xiaoyu Ma, Hui Wang
  • Patent number: 9040653
    Abstract: This disclosure provides methods of controlled polymerization of cyclic compounds catalyzed by carbene derivatives having a general formula as shown below, and to obtain a biodegradable polymeric material having a large molecular weight, a narrow dispersity, and no metallic impurity.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: May 26, 2015
    Assignee: NANJING UNIVERSITY OF TECHNOLOGY
    Inventors: Zhenjiang Li, Pingkai Ouyang, He Huang
  • Publication number: 20150119576
    Abstract: There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.
    Type: Application
    Filed: December 29, 2014
    Publication date: April 30, 2015
    Inventors: Manabu YAOSAKA, Tomohisa UTSUNOMIYA, Yuji MORIYAMA, Tomohiro MATSUMOTO, Kazutaka MATOBA
  • Publication number: 20150119395
    Abstract: The present invention relates to novel triazole Hsp90 inhibitors that possess significant inhibitory activity against Hsp90, which are suitable for the treatment of hyperproliferative diseases such as cancer, infections, immune disorders, inflammation, and CNS related disorders. Furthermore, pharmaceutical compositions, including combination products, are also provided in the present application. Further provided are methods of using the pharmaceutical compositions and/or combination products.
    Type: Application
    Filed: April 4, 2013
    Publication date: April 30, 2015
    Inventors: Dinesh U. Chimmanamada, Weiwen Ying
  • Patent number: 8946272
    Abstract: The invention relates to crystalline forms of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid and to its amorphous form, to processes for the preparation thereof, to compositions containing the same and their uses for the manufacture of a medicament for the treatment of the human body.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: February 3, 2015
    Assignee: Novartis AG
    Inventor: Michael Mutz
  • Publication number: 20150011517
    Abstract: The present invention relates to a lupane triterpenoid derivatives and pharmaceutical use thereof, specifically relates to a lupane triterpenoid derivatives of formula (I)˜(III), a pharmaceutical composition and a combination preparation comprising a lupane triterpenoid derivatives or a pharmaceutically acceptable salt thereof in a therapeutically-effective dose, particularly relates to the use in preparation of a medicament for the treatment of HIV-1/AIDS.
    Type: Application
    Filed: January 30, 2013
    Publication date: January 8, 2015
    Inventor: Feng Lu
  • Patent number: 8916183
    Abstract: This document discloses molecules having the following formulas (“Formula One” &“Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: December 23, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Lindsey G. Fischer, Gary D. Crouse, Thomas C. Sparks, Erich W. Baum
  • Publication number: 20140343293
    Abstract: The invention provides a 1,2,4-triazole-based derivative, a production process and use thereof, and an organic electroluminescent device. The invention belongs to the technical field of organic electroluminescence, and can give a blue light-emitting material having a higher luminescence efficiency. The 1,2,4-triazole-based derivative has a molecular structure of the following general formula, wherein A group represents an aromatic heterocyclic group having a carbon atom number of 8-18, a fused-ring aromatic group having a carbon atom number of 9-15, a fluorenyl group, or a triarylamino group. The 1,2,4-triazole-based derivative mentioned in the invention can be used in organic electroluminescent device.
    Type: Application
    Filed: January 27, 2014
    Publication date: November 20, 2014
    Applicants: JiLin OLED Material Tech. Co., LTD., BOE Technology Group Co., LTD.
    Inventors: Na Li, Yansong Li, Xiaoyu Ma, Hui Wang
  • Publication number: 20140336230
    Abstract: The present invention provides a method for increasing metabolism and/or energy expenditure in a subject, e.g., to treat or prevent obesity and/or a related condition and/or the reduce adiposity, the method comprising increasing the level and/or activity of Hypoxia Induced Factor 1? (HIF-1?) in a cell, tissue or organ of the subject, thereby increasing metabolism in the subject. The present invention also provides a method for increasing metabolism in a subject, the method comprising administering an iron chelating agent to the subject, thereby increasing metabolism in the subject.
    Type: Application
    Filed: December 4, 2013
    Publication date: November 13, 2014
    Applicant: Garvan Institute of Medical Research
    Inventor: Jenny Gunton
  • Publication number: 20140288301
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 25, 2014
    Inventors: Dinesh U. Chimmanamada, Joseph A. Burlison, Weiwen Ying, Lijun Sun, Stefan M. Schweizer, Shijie Zhang, Zachary Demko, David James, Teresa Kowalczyk-Przewloka
  • Publication number: 20140275524
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Lindsey G. Fischer, Andrew L. Ward, Ronald Ross, JR., Natalie C. Giampietro, Carl DeAmicis, Yan Hao, Gary D. Crouse, Thomas C. Sparks, Erich W. Baum, Jeff Petkus
  • Publication number: 20140275560
    Abstract: The invention in this document is related to the field of preparation of 1,3-(substituted-diaryl)-1,2,4-triazoles and certain intermediates derived therefrom, where said intermediates are useful in the preparation of certain pesticides disclosed in U.S. Pat. No. 8,178,658.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 18, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: Natalie C. GIAMPIETRO, Gary D. CROUSE, Gregory T. WHITEKER
  • Publication number: 20140275563
    Abstract: The invention in this document is related to the field of preparation of 1,3-(substituted-diaryl)-1,2,4-triazoles and certain intermediates derived therefrom, where said intermediates are useful in the preparation of certain pesticides disclosed in U.S. Pat. No. 8,178,658.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 18, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: Natalie C. GIAMPIETRO, Gary D. CROUSE, Gregory T. WHITEKER
  • Publication number: 20140275564
    Abstract: Aryl or heteroaryl 1-substituted triazoles are prepared from 3-bromo-1H-1,2,4-triazole by reaction with a brominated or iodinated aryl or heteroaryl group.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 18, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: William Hunter DENT, III, Natalie C. GIAMPIETRO
  • Publication number: 20140274688
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Lindsey G. Fischer, Erich W. Baum, Gary D. Crouse, Carl DeAmicis, Beth Lorsbach, Jeff Petkus, Thomas C. Sparks, Gregory T. Whiteker
  • Publication number: 20140275565
    Abstract: Aryl or heteroaryl 1-substituted triazoles are prepared by cyclizing aryl or heteroaryl hydrazines with urea and alkyl orthoformates.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 18, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: Natalie C. GIAMPIETRO, William Hunter DENT, III
  • Patent number: 8829198
    Abstract: Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of ?-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: September 9, 2014
    Assignee: Proteotech Inc
    Inventors: Luke A. Esposito, F. Michael Hudson, Thomas Lake, Joel Cummings, Manfred Weigele, Alan D. Snow, Lesley Larsen
  • Publication number: 20140239269
    Abstract: A pyrene-based compound, and an organic light-emitting diode including the pyrene-based compound are provided.
    Type: Application
    Filed: August 5, 2013
    Publication date: August 28, 2014
    Inventors: Eun-Jae Jeong, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jun-Ha Park, Eun-Young Lee, Jin-O Lim, Sang-Hyun Han, Soo-Yon Kim, Jong-Hyuk Lee
  • Patent number: 8816070
    Abstract: 5-[4-(2-Methylphenyl)-3-hydroxy-4H-1,2,4-triazol-5-yl]-2,4-dihydroxy-N-methyl-N-butylbenzamide is an HSP90 inhibitor and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: August 26, 2014
    Assignee: Merck Patent GmbH
    Inventors: Hans Michael Eggenweiler, Michael Wolf, Hans Peter Buchstaller, Christian Sirrenberg
  • Publication number: 20140235684
    Abstract: A metal-salen complex compound responsive drug, which has an antidotal property capable of neutralizing cytotoxicity of a metal-salen complex compound, and an intra-corporeal behavior control system for the metal-salen complex compound are provided. This metal-salen complex compound responsive drug contains an effective amount of a metal chelating agent to suppress side effects by the metal-salen complex compound.
    Type: Application
    Filed: September 19, 2012
    Publication date: August 21, 2014
    Inventors: Yoshihiro Ishikawa, Haruki Eguchi
  • Publication number: 20140228215
    Abstract: This document discloses pesticidal compostions comprising molecules having the following formulas: and processes related thereto.
    Type: Application
    Filed: April 23, 2014
    Publication date: August 14, 2014
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Gary D. Crouse, William T. Lambert, Thomas C. Sparks, Vidyadhar B. Hegde
  • Publication number: 20140221332
    Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.
    Type: Application
    Filed: May 25, 2012
    Publication date: August 7, 2014
    Applicant: SUNOVION PHARMACEUTICALS INC.
    Inventors: Michele L. R. Heffernan, Larry Wendell Hardy, Frank Xinhe Wu, Lakshmi D. Saraswat
  • Publication number: 20140206668
    Abstract: This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.
    Type: Application
    Filed: March 25, 2014
    Publication date: July 24, 2014
    Applicant: Dow AgroSciences LLC
    Inventors: Gary D. Crouse, Thomas C. Sparks, William H. Dent, III, CaSandra L. McLeod, Lawrence C. Creemer, David A. Demeter, Amanda E. Fritz, Lindsey G. Fischer, Erich W. Baum
  • Publication number: 20140197384
    Abstract: A condensed cyclic compound represented by Formula 1 below and an organic light-emitting device (OLED) including the condensed cyclic compound are presented. Ar1 and Ar2 in Formula 1 are each independently one of a hydrogen atom, an aryl or heteroaryl group and an arylamino group, at least one of Ar1 and Ar2 being a substituted or unsubstituted 1,2.4-triazol-4-yl group; L1 and L2 in Formula 1 are linking groups, each independently one of a cyclic or noncyclic, saturated or unsaturated hydrocarbon group and a heteroarylene group; a and b in Formula 1 are each independently one of 0 or 1; and R1 to R8 in Formula 1 being each independently one of a variety of inorganic and organic substituents including cyclic or noncyclic, saturated or unsaturated and aromatic, nonaromatic or heteraromatic groups. The OLED may have a low driving voltage, a high emission efficiency and long lifespan characteristics.
    Type: Application
    Filed: August 28, 2013
    Publication date: July 17, 2014
    Inventors: Seul-Ong Kim, O-Hyun Kwon, Dong-Woo Shin, Mie-Hwa Park, Bum-Sung Lee
  • Patent number: 8772276
    Abstract: The present invention is directed to alkyne benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: July 8, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Scott D. Kuduk, Jason W. Skudlarek
  • Patent number: 8748340
    Abstract: This document discloses pesticidal compostions comprising molecules having the following formulas: and processes related thereto.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: June 10, 2014
    Assignee: Dow AgroSciecnes LLC.
    Inventors: Gary D. Crouse, William Thomas Lambert, Thomas C. Sparks, Vidyadhar B. Hegde
  • Patent number: 8742133
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: June 3, 2014
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Weiwen Ying, Lijun Sun, Keizo Koya, Dinesh U. Chimmanamada, Shijie Zhang, Teresa Kowalcyzk-Przewloka, Hao Li
  • Patent number: 8735398
    Abstract: The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: May 27, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Omar D. Lopez, Denis R. St. Laurent, Jason Goodrich, Jeffrey Lee Romine, Michael Serrano-Wu, Fukang Yang, Ramesh Kakarla, Xuejie Yang, Yuping Qiu, Lawrence B. Snyder
  • Publication number: 20140080842
    Abstract: The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.
    Type: Application
    Filed: May 11, 2012
    Publication date: March 20, 2014
    Applicant: B.R.A.I.N. Biotechnology Research and Information Network AG
    Inventors: Michael Krohn, Dirk Sombroek
  • Publication number: 20140046069
    Abstract: Arylpyrrolidines of Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal paracite-controlling agents.
    Type: Application
    Filed: September 13, 2011
    Publication date: February 13, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Jun Mihara, Mamoru Hatazawa, Daiei Yamazaki, Hidetoshi Kishikawa, Kei Domon, Hidekazu Watanabe, Norio Sasaki, Tetsuya Murata, Koichi Araki, Eiichi Shimojo, Teruyuki Ichihara, Tadashi Ishikawa, Katsuhiko Shibuya, Ulrich Goergens, Peter Bruechner, Reiner Fischer, Johannes-Rudolf Jansen, Tobias Kapferer, Simon Maechling, Michael Maue, Arnd Voerste
  • Publication number: 20140039199
    Abstract: The present invention provides improved process for the preparation of Deferasirox of formula (I).
    Type: Application
    Filed: November 4, 2011
    Publication date: February 6, 2014
    Inventors: Jayaraman Venkat Raman, Hiral Shah
  • Publication number: 20130289003
    Abstract: A compound having the structure: useful for treating hypertension, Pulmonary Arterial Hypertension (PAH), congestive heart failure, conditions resulting from excessive water retention, cardiovascular disease, diabetes, oxidative stress, endothelial dysfunction, cirrhosis, pre-eclampsia, osteoporosis or nephropathy.
    Type: Application
    Filed: October 25, 2011
    Publication date: October 31, 2013
    Inventors: Amjad Ali, Michael Man-Chu Lo, Robert K. Baker, Zhiqiang Guo, Brent Whitehead, Timothy J. Henderson, Edward Metzger, Lin Yan, Shrenik K. Shah, James Dellureficio, Jun Wang
  • Publication number: 20130267572
    Abstract: The invention relates to crystalline forms of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid and to its amorphous form, to processes for the preparation thereof, to compositions containing the same and their uses for the manufacture of a medicament for the treatment of the human body.
    Type: Application
    Filed: April 2, 2013
    Publication date: October 10, 2013
    Applicant: NOVARTIS AG
    Inventor: Michael Mutz
  • Publication number: 20130237583
    Abstract: The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R1 is chlorodifluoromethyl or trifluoromethyl; R2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R1 and R2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R1 and R2 are as defined for the compound of formula I; and (a-ii) reductively cyclising the compound of formula III to give the compound of formula I.
    Type: Application
    Filed: June 14, 2011
    Publication date: September 12, 2013
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Myriem El Qacemi, Helmars Smits, Jerome Yves Cassayre, Nicholas Phillip Mulholland, Peter Renold, Edouard Godineau, Thomas Pitterna
  • Publication number: 20130231489
    Abstract: Organometallic complexes which bear at least one ligand which has a unit having a triplet energy of at least 22 000 cm?1, a process for preparing the organometallic complexes, a mixture comprising at least one inventive organometallic complex, the use of the organometallic complexes or of the mixture in organic light-emitting diodes, the organometallic complexes preferably being used as emitter materials, and specific nitrogen- or phosphorus-substituted triphenylene derivatives and a process for their preparation.
    Type: Application
    Filed: April 16, 2013
    Publication date: September 5, 2013
    Applicant: BASF SE
    Inventors: Herbert Friedrich BOERNER, Hans-Peter LOEBL, Josef SALBECK, Elena POPOVA
  • Publication number: 20130196971
    Abstract: This invention relates to the use of imidazole, triazole, and tetrazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of imidazoles, triazoles, and tetrazoles in the treatment of cancer.
    Type: Application
    Filed: September 15, 2011
    Publication date: August 1, 2013
    Inventors: Christopher Joseph Aquino, Dennis Heyer, Terence John Kiesow, David Lee Musso, Cynthia A. Parrish
  • Patent number: 8440838
    Abstract: An aryl (1H-1,2,4-triazol-1-yl) compound is useful for producing a 3-(1H-1,2,4-triazol-1-yl)phenylsulfide compound (useful, e.g., as an insecticide). Also disclosed is a process for producing the compound. The aryl (1H-1,2,4-triazol-1-yl) compound is represented by the general formula (1), below, wherein R represents a C1-C6 alkyl group or a cyclic C3-C6 alkyl group; A1 represents a hydrogen atom, an amino group, a mono(C1-C6 alkyl amino group or a di (C1-C6 alkyl) amino group; A2 represents a halogen atom, a C1-C6 alkyl group or a cyclic C3-C6 alkyl group; and Z represents a hydrogen atom, a halo-sulfonyl group or a mercapto group.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: May 14, 2013
    Assignee: Ihara Chemical Industry Co., Ltd.
    Inventor: Kentaro Kawazoe
  • Patent number: 8436030
    Abstract: The invention relates to crystalline forms of 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]benzoic acid and to its amorphous form, to processes for the preparation thereof, to compositions containing the same and their uses for the manufacture of a medicament for the treatment of the human body.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: May 7, 2013
    Assignee: Navartis AG
    Inventor: Michael Mutz
  • Publication number: 20130023539
    Abstract: The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
    Type: Application
    Filed: June 18, 2012
    Publication date: January 24, 2013
    Applicant: Euroscreen S.A.
    Inventors: Hamid R. Hoveyda, Didier Schils, Ludivine Zoute, Julien Parcq
  • Publication number: 20130023666
    Abstract: A process for production of a (1H-1,2,4-triazol-1-yl)benzene compound represented the general formula (5) [wherein R is a C1 to C6 alkyl group or a cyclic C1 to C6 alkyl group; A1 is a hydrogen atom, an amino group, a mono(C1 to C6 alkyl)amino group or a di(C1 to C6 alkyl)amino group; and A2 is a halogen atom, a C1 to C6 alkyl group or a cyclic C1 to C6 alkyl group], which comprises reacting a triazole compound represented by the general formula (2) (wherein A1 has the same definition as given above) with a phenylboronic acid compound represented by the general formula (3) (wherein R and A2 have the same definitions as given above) or a phenylboroxine compound represented by the general formula (4) (wherein R and A2 have the same definitions as given above) in the presence of a copper catalyst.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 24, 2013
    Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.
    Inventor: IHARA CHEMICAL INDUSTRY CO., LTD.
  • Publication number: 20130019348
    Abstract: This document discloses molecules having the following formula (“Formula One”) The molecules disclosed in this document are related to the field of processes to produce molecules that are useful as pesticides (e.g., acaricides, insecticides, molluscicides, and nematicides), such molecules, and processes of using such molecules to control pests.
    Type: Application
    Filed: July 11, 2012
    Publication date: January 17, 2013
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Gary D. Crouse, David A. Demeter, Thomas C. Sparks, Nick X. Wang, William H. Dent, III, Carl Deamicis, Noormohamed M. Niyaz, Erich W. Baum, Lindsey G. Fischer, Natalie C. Giampietro
  • Publication number: 20120329649
    Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 27, 2012
    Inventors: James E. Hunter, William C. Lo, Gerald B. Watson, Akshay Patny, Gary D. Gustafson, Dan Pernich, William K. Brewster, Debra L. Camper, Beth Lorsbach, Michael R. Loso, Thomas C. Sparks, Hemant Joshi, Adiraj Mandaleswaran, Ramadevi Sanam, Rambabu Gundla, Pravin S. Iyer
  • Patent number: 8299066
    Abstract: This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 is hydrogen or substituted or unsubstituted alkyl, Ring A is monocyclic or bicyclic aromatic heterocycle, R3 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocycle, R4 is halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like, m is an integer between 0 and 2, n is an integer between 0 and 5, R is halogen, oxo, cyano, nitro, substituted or unsubstituted alkyl or the like, and p is an integer between 0 and 2 as novel compounds having NPY Y5 antagonistic activity.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: October 30, 2012
    Assignee: Shionogi & Co., Ltd.
    Inventors: Masahiro Sakagami, Hiroshi Hashizume, Satoru Tanaka
  • Publication number: 20120258986
    Abstract: The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).
    Type: Application
    Filed: January 16, 2012
    Publication date: October 11, 2012
    Applicant: KARYOPHARM THERAPEUTICS, INC.
    Inventors: Vincent P. Sandanayaka, Sharon Shacham, Sharon Shechter, Dilara McCauley
  • Publication number: 20120245361
    Abstract: The present invention relates to processes for the preparation of deferasirox, an oral iron chelator developed to treat iron overload due to e.g. multiple blood transfusions. The present invention further provides novel deferasirox pseudopolymorphs and a novel amorphous form of deferasirox, processes for their preparation, as well as pharmaceutical compositions comprising same, and use thereof in treating iron overload.
    Type: Application
    Filed: January 28, 2010
    Publication date: September 27, 2012
    Applicant: MAPI PHARMA HK LIMITED
    Inventors: Michael Mizhiritskii, Ehud Marom, Shai Rubnov
  • Publication number: 20120238581
    Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.
    Type: Application
    Filed: May 31, 2012
    Publication date: September 20, 2012
    Inventors: Andrew J. Souers, Ju Gao, Todd M. Hasen, Rajesh R. Iyengar, Philip R. Kym, Bo Liu, Zhonghua Pei, Vince S. Yeh, Gang Zhao, Zhili Xin
  • Publication number: 20120202834
    Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.
    Type: Application
    Filed: February 7, 2012
    Publication date: August 9, 2012
    Applicant: PFIZER INC.
    Inventors: Gary Erik Aspnes, Mary Theresa Didiuk, Kevin James Filipski, Angel Guzman-Perez, Esther Cheng Yin Lee, Jeffrey Allen Pfefferkorn, Benjamin Dawson Stevens, Meihua Mike Tu
  • Publication number: 20120202687
    Abstract: This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.
    Type: Application
    Filed: February 6, 2012
    Publication date: August 9, 2012
    Inventors: Gary D. Crouse, Thomas C. Sparks, William H. Dent, III, CaSandra L. McLeod, Lawrence C. Creemer, David A. Demeter, Amanda E. Fritz, Lindsey G. Fischer, Erich W. Baum
  • Publication number: 20120202688
    Abstract: This document discloses pesticidal compostions comprising molecules having the following formulas: and processes related thereto.
    Type: Application
    Filed: February 8, 2012
    Publication date: August 9, 2012
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Gary D. Crouse, William T. Lambert, Thomas C. Sparks, Vidyadhar B. Hegde