Patent number: 6753327
Abstract: An amide of the formula I
and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings:
A —(CH2)p—R1, where R1 can be pyrrolidine, morpholine, piperidine, —NR5R6 and
and R5, R6 and R7 can, independently of one another, be hydrogen, C1-C4-alkyl, CH2Ph, Ph, CH2CH2Ph, it also being possible for the phenyl rings to be substituted by R6, and p can be 1 and 2, and
B can be phenyl, pyridyl, pyrimidyl and pyridazyl, it also being possible for the rings to be substituted by up to 2 R8 radicals, and
D can be a bond, —(CH2)m, —CH═CH—, —C≡C—, and
Y is phenyl, pyridine, pyrimidine and pyrazine and
n is a number 0, 1 or 2, and
m,q are, independently of one another, a number 0, 1, 2, 3 or 4.
Type:
Grant
Filed:
October 11, 2000
Date of Patent:
June 22, 2004
Assignee:
Abbott GmbH & Co. KG
Inventors:
Wilfried Lubisch, Achim Möller, Hans-Jörg Treiber, Monika Knopp