The Spiro Includes The Lactone Ring Patents (Class 549/265)
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Publication number: 20110319808Abstract: A composition for use on skin and wounds, comprising a photo-catalyst which is capable of preferentially staining biofilms the composition being for use in the diagnosis and treatment of biofilms in wounds.Type: ApplicationFiled: December 18, 2009Publication date: December 29, 2011Applicant: ConvaTec Technologies Inc.Inventors: Phillip Godfrey Bowler, Daniel Gary Metcalf, David Parsons
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Publication number: 20110306499Abstract: The invention relates to novel compounds of the formula (I) in which W, X, Y, Z and CKE have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising, firstly, the compounds of the formula (I) and, secondly, at least one crop plant compatibility-improving compound. The invention further relates to the boosting of the action of crop protection compositions comprising compounds of the formula (I) through the additions of ammonium salts or phosphonium salts and optionally penetrants.Type: ApplicationFiled: November 22, 2007Publication date: December 15, 2011Applicant: Bayer CropScience AGInventors: Thomas Bretschneider, Reiner Fischer, Rolf Pontzen, Christian Arnold, Ulrich Görgens, Olga Malsam, Udo Reckmann, Erich Sanwald, Stefan Lehr, Jan Dittgen, Dieter Feucht, Martin Hills, Christopher Rosinger
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Publication number: 20110294783Abstract: The present invention concerns boosting the activity of crop protection materials comprising inhibitors of fatty acid biosynthesis (for example phenyl-substituted cyclic ketoenols) through the addition of ammonium salts and/or phosphonium salts or through the addition of ammonium salts and/or phosphonium salts and penetrants, the corresponding materials, processes for preparing them, and their use in crop protection.Type: ApplicationFiled: August 10, 2011Publication date: December 1, 2011Applicant: BAYER CROPSCIENCE AGInventors: Reiner FISCHER, Stefan LEHR, Peter MARCZOK, Udo Reckmann, Christian Arnold, Waltraud Hempel, Erich SANWALD, Rolf Pontzen
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Patent number: 8058288Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.Type: GrantFiled: June 17, 2010Date of Patent: November 15, 2011Assignee: Incyte CorporationInventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Colin Zhang, Brian W. Metcalf, Chunhong He, Ding-Quan Qian
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Publication number: 20110275709Abstract: Use of tellurium-containing compounds for maintaining and/or augmenting fertility in a male subject following chemotherapy and/or radiotherapy is disclosed. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and/or radiation, such that the male subject treated by the chemotherapeutic agent and/or radiation and by the tellurium-containing compound is instructed to refrain from conceptive sex for a pre-determined time period, following the chemotherapy and/or radiotherapy, during which conception is undesired.Type: ApplicationFiled: January 7, 2010Publication date: November 10, 2011Applicant: BIOMAS LTD.Inventors: Benjamin Sredni, Michael Albeck, Benjamin Ron
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Patent number: 8034928Abstract: Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such as proteins, peptides or nucleic acids. The blocking group(s) is released from the latent fluorescent compound by reaction with a trigger, forming the fluorescent molecule which can be detected. Also provided herein are methods of using latent fluorescent compounds to detect triggers.Type: GrantFiled: April 21, 2009Date of Patent: October 11, 2011Assignees: Wisconsin Alumni Research Foundation, The Penn State Research FoundationInventors: Ronald T. Raines, Sunil S. Chandran, Timothy E. Glass, Luke D. Lavis
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Publication number: 20110226610Abstract: Inventors have developed a chromophore (nitrodibenzylfuranyl, or NBDF) for ultra efficient uncaging of a caged substrate (e.g., an organic molecule such as, for example, an amino acid, a biological molecules, such as, for example, second messengers inside cells). Photolysis of a NBDF derivative of EGTA (i.e. caged calcium) is about 50 times more efficient than others calcium cages (the quantum yield of photolysis is 0.6 and the extinction coefficient is 18,400. NDBF-EGTA has a 2-photon cross section of about 0.3-0.6 GM).Type: ApplicationFiled: February 18, 2011Publication date: September 22, 2011Applicant: Philadelphia Health & Education Corporation d/b/a Drexel University College of MedicineInventors: Graham Ellis-Davies, Atsuya Momotake
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Publication number: 20110213160Abstract: The invention relates to novel 2,4,6-phenyl-substituted cyclic ketoenols of the formula (I), in which CKE, W, X and Y are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly the 2,4,6-phenyl-substituted cyclic ketoenols and secondly at least one compound which improves crop plant tolerance.Type: ApplicationFiled: April 15, 2011Publication date: September 1, 2011Applicant: BAYER CROPSCIENCE AGInventors: Thomas BRETSCHNEIDER, Reiner Fischer, Oliver Gaertzen, Klaus Kunz, Stefan Lehr, Dieter Feucht, Peter Lösel, Olga Malsam, Guido Bojack, Christian Arnold, Thomas Auler, Jeffrey Martin Hills, Heinz Kehne, Chris Rosinger
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Publication number: 20110196027Abstract: The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.Type: ApplicationFiled: February 4, 2009Publication date: August 11, 2011Inventors: Stephan A. Sieber, Thomas Böttcher
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Publication number: 20110195842Abstract: The invention relates to novel 2,4,6-phenyl-substituted cyclic ketoenols of the formula (I), in which CKE, W, X and Y are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly the 2,4,6-phenyl-substituted cyclic ketoenols and secondly at least one compound which improves crop plant tolerance.Type: ApplicationFiled: April 15, 2011Publication date: August 11, 2011Applicant: BAYER CROPSCIENCE AGInventors: Thomas BRETSCHNEIDER, Reiner FISCHER, Oliver GAERTZEN, Klaus KUNZ, Stefan LEHR, Dieter FEUCHT, Peter LÖSEL, Olga MALSAM, Guido BOJACK, Christian ARNOLD, Thomas AULER, Martin Jeffrey HILLS, Heinz KEHNE, Chris ROSINGER
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Publication number: 20110190493Abstract: The invention relates to novel spiroketal-substituted cyclic ketoenols of the formula (I) in which A, B, Q1, Q2, D, G, W, X, Y, and Z are as defined above, to processes and intermediates for their preparation and to their use as pesticides and/or microbicides and/or herbicides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, spiroketal-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound.Type: ApplicationFiled: February 25, 2011Publication date: August 4, 2011Applicant: Bayer CropScience AGInventors: Thomas Bretschneider, Reiner Fischer, Oliver Gaertzen, Stefan Lehr, Mark Wilhelm Drewes, Dieter Feucht, Olga Malsam, Udo Reckmann, Christian Arnold, Thomas Auler, Waltraud Hempel, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Erich Sanwald
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Publication number: 20110166297Abstract: Molecularly imprinted smart polymers (MISPs) are provided herein, as well as novel monomers for preparing MISPs, and processes for preparing MISPs. The MISPs can be used applications such as, for example, detecting/absorbing or isolating biological and non-biological agents. The MISPs described herein comprise responsive monomeric units which undergo a physico-chemical change (e.g., a bond formation or cleavage) in response to an external change, such that the MISP selectively binds to a target molecule and releases a bound target molecule in response to the external change.Type: ApplicationFiled: September 9, 2009Publication date: July 7, 2011Applicant: Sailo Nanotechnologies Ltd.Inventors: Flavio Grynszpan, Eran Partouche, Vladimir Shkoulev, Alex Aizikovich, Sharon Gazal, Rachel Nakash-Ozeri, Isaac Zigelboim
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Patent number: 7960368Abstract: Described herein are bismethylene-17? carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.Type: GrantFiled: March 4, 2009Date of Patent: June 14, 2011Assignee: Everstra, Inc.Inventors: Klaus Nickisch, Pemmaranu N. Rao, James W. Cessac, Anne Marie Simmons
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Publication number: 20110098487Abstract: There are described novel rhodamine color-forming compounds. The rhodamine color-forming compounds exhibit a first color when in a crystalline form and a second color, different from the first color, when in an amorphous form. Thermal imaging members containing these color-formers are also described.Type: ApplicationFiled: August 26, 2010Publication date: April 28, 2011Inventors: Kap-Soo Cheon, Michael P. Filosa, Fariza Hasan, Xavier Herault, John L. Marshall
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Publication number: 20110059907Abstract: This invention relates to certain complexes of ascorbic acid and its derivatives with certain natural antioxidant and anti-inflammatory ketones for topical or oral application; said complexes having general chemical formula (I), its isomers, and salts thereof, including their optically active or racemic forms.Type: ApplicationFiled: November 16, 2010Publication date: March 10, 2011Applicant: Island Kinetics Inc.Inventors: SHYAM K. GUPTA, Linda Walker
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Patent number: 7888518Abstract: A preparation method of a dye incorporated in a recording layer for a high density optical recording medium, having the following general chemical structural formula (I): is provided.Type: GrantFiled: June 1, 2009Date of Patent: February 15, 2011Assignee: Industrial Technology Research InstituteInventors: Ming-Chia Lee, Chien-Liang Huang, Wen-Yih Liao, Ching-Yu Hsieh, Tzuan-Ren Jeng, An-Tse Lee
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Publication number: 20110021624Abstract: Disclosed are a series of ?-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The ?-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.Type: ApplicationFiled: December 11, 2008Publication date: January 27, 2011Inventors: Fajun Nan, Jia Li, Jian Ding, Gang Liu, Chuanming Xie, Zehong Miao, Wanyi Tai
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Publication number: 20100330685Abstract: A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X? represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.Type: ApplicationFiled: June 29, 2010Publication date: December 30, 2010Applicants: SEKISUI MEDICAL CO., LTD.Inventors: Tetsuo Nagano, Hirotatsu Kojima, Kazuya Kikuchi
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Publication number: 20100279873Abstract: The invention relates to novel haloalkoxyspirocyclic tetramic and tetronic acid derivatives of the formula (I) in which W, X, Y, Z, A, D, Q1, Q2, m and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides. Moreover, the invention provides selective herbicidal compositions comprising, firstly, haloalkoxyspirocyclic tetramic and tetronic acid derivatives and, secondly, a crop plant compatibility-improving compound. The invention furthermore relates to increasing the action of crop protection compositions comprising compounds of the formula (I) through the addition of ammonium salts or phosphonium salts and optionally penetrants.Type: ApplicationFiled: September 12, 2008Publication date: November 4, 2010Applicant: BAYER CROPSCIENCE AGInventors: Reiner Fischer, Thomas Bretschneider, Stefan Lehr, Christian Arnold, Jan Dittgen, Dieter Feucht, Heinz Kehne, Olga Malsam, Christopher Hugh Rosinger, Eva-Maria Franken, Ulrich Görgens
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Patent number: 7781044Abstract: A recording layer including a novel organic compound for a high density optical recording medium is provided. The information may be recorded on the recording layer at a 2× speed or higher speed with a relatively lower writing power so that heat distribution of the recording layer in the irradiated area is not likely to become steep both in time and space. The organic compound incorporated in the recording layer has the following general chemical structural formula (I).Type: GrantFiled: September 5, 2007Date of Patent: August 24, 2010Assignee: Industrial Technology Research InstituteInventors: Ming-Chia Li, An-Tse Lee, Chien-Liang Huang, Chung-Ta Cheng, Kuo-Chi Chiu, Tzuan-Ren Jeng
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Patent number: 7776874Abstract: The present invention relates to inhibitors of 11-? hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-? hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.Type: GrantFiled: June 10, 2008Date of Patent: August 17, 2010Assignee: Incyte CorporationInventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Brian W. Metcalf, Chunhong He, Ding-Quan Qian, Colin Zhang
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Publication number: 20100204327Abstract: Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.Type: ApplicationFiled: August 23, 2005Publication date: August 12, 2010Inventors: Wayne J. Brouillette, Donal D. Muccio, Venkatram Reddy Atigadda, John M. Ruppert, Susan M. Lobo Ruppert
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Publication number: 20100190159Abstract: It is an object of the present invention to provide an on-off type fluorescent compound used in gene analyses, which is highly stable and highly sensitive, and which enables amplification of a trace amount of gene signal and observation thereof. The present invention provides a compound represented by the following formula (1) or (2): wherein R1 represents an alkyl group containing 1 to 6 carbon atoms, an amino group, an amide group optionally having a protecting group or a substituent, a halogen atom, or a hydrogen atom; R2 independently represents an alkyl group containing 1 to 6 carbon atoms, a halogen atom, or a hydrogen atom; R3 represents an alkyl group containing 1 to 6 carbon atoms, an aryl group, or a hydrogen atom; R4 represents a group containing an oxygen atom, or a hydrogen atom, wherein R3 may bind to R4 to form a ring.Type: ApplicationFiled: December 19, 2007Publication date: July 29, 2010Applicant: RIKENInventors: Hiroshi Abe, Yoshihiro Ito, Jin Wang, Kazuhiro Furukawa
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Publication number: 20100172844Abstract: The invention relates to portable albumin binders, which are useful for improving the pharmacokinetic properties of diagnostic or therapeutic agents, in particular increasing the blood circulations time and/or the tissue penetration capacity of such agents.Type: ApplicationFiled: November 2, 2007Publication date: July 8, 2010Inventors: Dario Neri, Christoph Dumelin
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Publication number: 20100168226Abstract: The present invention relates to novel spirocyclic tetronic acid derivatives of the formula (I) in which R1, R2 and R3 have the meanings given in the description, to a plurality of processes for their preparation and to their use as pesticides.Type: ApplicationFiled: January 9, 2008Publication date: July 1, 2010Inventors: Reiner Fischer, Thomas Bretschneider, Hubertus Schulte, Gerhard Krautstrunk, Christian Arnold, Erich Sanwald
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Patent number: 7718242Abstract: A recording layer including a novel dye for a high density optical recording medium, employing short wavelength laser source with a wavelength not longer than 530 nm for recording high density information and reproduction/playback of the high density information recordings, is provided.Type: GrantFiled: February 7, 2007Date of Patent: May 18, 2010Assignee: Industrial Technology Research InstituteInventors: Ming-Chia Li, Chien-Liang Huang, An-Tze Lee, Wen-Yih Liao, Ching-Yu Hsieh, Tzuan-Ren Jeng
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Publication number: 20100113460Abstract: Disclosed are compounds having the ability to inhibit cytochrome P450 2A6, 2A13, and/or 2B6 and tobacco products comprising them. Also disclosed are pharmaceutical compositions comprising them.Type: ApplicationFiled: March 20, 2008Publication date: May 6, 2010Applicant: Givaudan SAInventors: Boris Schilling, Wolf D. Woggon, Antoinette Chougnet, Thierry Granier, Georg Frater, Andreas Hanhart
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Publication number: 20100105673Abstract: The present invention relates to novel substituted aminofurans, to methods for their preparation, to their use in the treatment and/or prophylaxis of diseases as well as their use in the manufacture of medical products for the treatment and/or prophylaxis of diseases, in particular retroviral disorders, in humans and/or animals.Type: ApplicationFiled: December 8, 2007Publication date: April 29, 2010Applicant: Bayer Schering Pharma AktiengesellschaftInventors: Adrian Tersteegen, Dirk Heimbach, Kai Thede, Reinhold Welker, Beate Fast, Arnold Paessens, Frank Dittmer, Rudolf Schohe-Loop, Axel Harrenga, Alexander Hillisch, Kerstin Henninger, Walter Hübsch, Marcus Bauser, Susanne Greschat, Dirk Schneider, Tobias Marquardt, Andreas Göller, Andreas Urban, Steffen Wildum, Daniela Paulsen
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Publication number: 20100087320Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.Type: ApplicationFiled: November 12, 2009Publication date: April 8, 2010Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark-Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Publication number: 20100022527Abstract: The present invention relates to novel substituted spirotetronic acids (I) in which R1 and R2, together with the carbon atom to which they are bonded, form a group of the formula (1), (2), (3) or (4), whereby * represents the carbon atom to which R1 and R2 are bonded, to methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of retroviral disorders, in people and/or animals.Type: ApplicationFiled: February 25, 2009Publication date: January 28, 2010Applicant: AiCuris GMBH & Co. KGInventors: Dirk HEIMBACH, Adrian TERSTEEGEN, Kai THEDE, Reinhold WELKER, Beate FAST, Arnold PAESSENS, Frank DITTMER, Rudolph SCHOHE-LOOP, Axel HARRENGA, Alexander HILLISCH, Kerstin HENNINGER, Walter HUEBSCH, Marcus BAUSER, Daniela PAULSEN, Alexander BIRKMANN, Thomas BRETSCHNEIDER, Reiner FISCHER, Susanne GRESCHAT, Andreas URBAN, Steffen WILDUM
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Publication number: 20090318548Abstract: This application relates to para-quinol derivatives, such as analogues of manumycins, aranorosins and gymnastatins. This application also relates to methods of synthesizing and using the para-quinol derivatives. In one embodiment of the invention a compound having the chemical structure (I) is provided wherein X1 and X2 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring or a hydroxyethylene moiety; X3 and X4 are carbon atoms either joined by double bond or joined by a single bond and comprising constituents of an epoxide ring; R1 is selected from the group consisting of branched alkyl chains, unbranched alkyl chains, cycloalkyl groups, aromatic groups, alcohols, ethers, amines, and substituted or unsubstituted ureas, esters, aldehydes and carboxylic acids; and R2 is selected from the group consisting of H, OH and NHR3 wherein R3 is a nitrogen protecting group.Type: ApplicationFiled: August 23, 2007Publication date: December 24, 2009Applicant: UNIVERSITY OF NORTHERN BRITISH COLUMBIAInventors: Guy L. Plourde, R. Randy Spaetzel
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Publication number: 20090305891Abstract: The disclosure relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I) in which J, X, Y, m and CKE are as defined above, to processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the disclosure relates to selective herbicidal compositions comprising, firstly, the cycloalkylphenyl-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The disclosure furthermore relates to increasing the activity of crop protection compositions comprising compounds of the formula (I) by adding ammonium or phosphonium salts and, if appropriate, penetrants.Type: ApplicationFiled: February 8, 2007Publication date: December 10, 2009Applicant: Bayer CropScience AGInventors: Reiner Fischer, Thomas Bretschneider, Stefan Lehr, Dieter Feucht, Eva-Maria Franken, Olga Malsam, Alfred Angermann, Guido Bojack, Christian Arnold, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger
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Publication number: 20090306333Abstract: The invention described herein provides a novel lactide monomer derivative and process for preparing the lactide monomer derivative. The monomer derivative of the invention is bifunctional in nature, and can be employed a variety of efficient synthesis processes to prepare various polymers. Further, the bifunctional monomer derivative can be used to prepare various intermediate-stage compounds and polymers, which in turn can be used to synthesize other compounds, polymers, copolymers and composites. The lactide monomer derivative has a bifunctional norbornene spiro lactide structure, spiro[6-methyl-1,4-dioxane-2,5-dione-3,2?-bicyclo[2.2.1]hept[5]ene], and structure as follows: and stereoisomers thereof. The lactide monomer derivative is bifunctional in that either 1) the norbornene ring, 2) lactide ring, or 3) both, can be opened and used in polymer synthesis for the backbone or the reactive branch for other polymeric syntheses.Type: ApplicationFiled: June 8, 2009Publication date: December 10, 2009Applicant: Regents of the University of MinnesotaInventors: Feng Jing, Marc Hillmyer
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Publication number: 20090299061Abstract: Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such as proteins, peptides or nucleic acids. The blocking group(s) is released from the latent fluorescent compound by reaction with a trigger, forming the fluorescent molecule which can be detected. Also provided herein are methods of using latent fluorescent compounds to detect triggers.Type: ApplicationFiled: April 21, 2009Publication date: December 3, 2009Inventors: Ronald T. RAINES, Sunil S. Chandran, Timothy E. Glass, Luke D. Lavis
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Publication number: 20090253118Abstract: Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the fluorogenic probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite or hypochlorite in chemical and biological samples.Type: ApplicationFiled: April 3, 2009Publication date: October 8, 2009Applicants: Versitech Limited, Morningside Ventures LimitedInventors: Dan YANG, Tao PENG
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Publication number: 20090253143Abstract: Provided herein are fluorophore compounds including rhodol and rhodamine compounds which can be used as fluorescent labels and/or fluorogenic probes and methods of making same. Provided also herein are methods that can be used to track, measure, detect, or screen biological species such as protein, DNA, enzyme, antibody, organelle, cell, tissue, drug, hormone, nucleotide, nucleic acid, polysaccharide or lipid in living organisms. Specifically, the methods include the steps of contacting any of the fluorophore compounds, rhodol compounds and rhodamine compounds disclosed herein with the biological species to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening biological species.Type: ApplicationFiled: April 3, 2009Publication date: October 8, 2009Applicants: Versitech Limited, Morningside Ventures LimitedInventors: Dan Yang, Tao Peng
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Publication number: 20090238969Abstract: A preparation method of a dye incorporated in a recording layer for a high density optical recording medium, having the following general chemical structural formula (I): is provided.Type: ApplicationFiled: June 1, 2009Publication date: September 24, 2009Applicant: Industrial Technology Research InstituteInventors: MING-CHIA LEE, Chien-Liang Huang, Wen-Yih Liao, Ching-Yu Hsieh, Tzuan-Ren Jeng, An-Tse Lee
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Publication number: 20090221019Abstract: Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et3SiH/BF3Et2O producing a series of lactol-free ginkgolides. The present invention also relates to synthesis of hydroxyl-free, or hydroxyl-free and lactone-free, ginkgolides and bilobalides.Type: ApplicationFiled: June 22, 2006Publication date: September 3, 2009Inventors: Koji Nakanishi, Sergei Dzyuba, Hideki Ishii
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Publication number: 20090162474Abstract: A chemical compound of the general formula I or II is useful as feed additive: wherein X=O or NR, and R=H, C1-C6-alkyl (optionally branched), C3-C6-cycloalkyl, aryl, or aralkyl, and wherein R1, R2, are identical or different and in each case H, C1-C6-alkyl (optionally branched), C3-C6-cycloalkyl, allyl, aryl, or aralkyl; or R1 and R2 together are an C2- to C6-alkylene group (optionally C1-C6-alkyl substituted).Type: ApplicationFiled: December 19, 2008Publication date: June 25, 2009Applicant: EVONIK DEGUSSA GmbHInventors: Christoph Kobler, Philipp Roth, Christoph Weckbecker, Klaus Huthmacher
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Publication number: 20090156668Abstract: The present invention relates to Ginkgolide derivatives, compositions and extracts comprising one or more Ginkgolides and/or derivatives thereof and methods of use of the compositions to treat neurological disorders and as imaging agents.Type: ApplicationFiled: March 21, 2005Publication date: June 18, 2009Applicant: The Trustees Of Columbia University In The City Of New YorkInventors: Ottavio V. Vitolo, Koji Nakanishi, Michael L. Shelanski, Sonja Krane, Ottavio Arancio, Stanislav Jaracz, Nina D. Berova
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Publication number: 20090061143Abstract: A recording layer including a novel organic compound for a high density optical recording medium is provided. The information may be recorded on the recording layer at a 2× speed or higher speed with a relatively lower writing power so that heat distribution of the recording layer in the irradiated area is not likely to become steep both in time and space. The organic compound incorporated in the recording layer has the following general chemical structural formula (I).Type: ApplicationFiled: September 5, 2007Publication date: March 5, 2009Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ming-Chia Li, An-Tse Lee, Chien-Liang Huang, Chung-Ta Cheng, Kuo-Chi Chiu, Tzuan-Ren Jeng
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Publication number: 20090029953Abstract: The invention relates to novel 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactones of general formula (I), where Z=O, H2, ?NOR or ?NNHSO2R, where R=H, a straight- or branched-chain 1-4 or 3-4 C alkyl group, R4=H, halogen, methyl or trifluoromethyl, R6 and/or R7 can be ?- or ?-positioned and independently=branched- or straight-chain 1-4 or 3-4 alkyl, or R6=H and R7=a- or ?-positioned, straight- or branched-chain 1-4 or 3-4 C alkyl, or R6 and R7=H, or R6 and R7 together=a- or ?-positioned methylene or an additional bond. The novel compounds have gestagenic and antimineralocorticoid activity and are suitable for the production of pharmaceutical preparations, for example, for oral contraception and the treatment of pre-, peri- and post-menopausal pain.Type: ApplicationFiled: December 30, 2005Publication date: January 29, 2009Inventors: Rolf Bohlmann, Dieter Bittler, Hermann Kuenzer, Peter Esperling, Hans Peter Muhn, Karl Heinrich Fritzemeier, Ulrike Fuhrmann, Katja Prelle, Steffen Borden
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Patent number: 7482449Abstract: This invention relates to a process for making spirolactone compounds analogous to formula I.Type: GrantFiled: March 19, 2008Date of Patent: January 27, 2009Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd.Inventors: Ralph P. Volante, David M. Tschaen, Steven A. Weissman, Matthew Heileman, Toshiaki Mase, Takehiko Iida, Kenji Maeda, Toshihiro Wada, Hiroki Sato, Kenichi Asakawa
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Patent number: 7473788Abstract: The subject invention provides compounds having the structure: wherein R1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R3 is H or OH; R4 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and wherein at least one of R1, R2, R3, or R4 is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety, or an optically pure enantiomer of the compound or wherein R1 is H or OH; R2 is H, OH, halogen, unsubstituted or substituted, straight or branched (C1-C5) alkyl group, (C2-C5) alkenyl, or a (C2-C5) alkynyl, (C1-C5) alkoxy, (C2-C5) alkenyloxy, or (C2-C5) alkynyloxy, —N3, —COR5, —CONR5R6, —CO2R5, —OCOR5, —NH(OH), —NR5R6, —NHCOR5, —N(OH)COR5, —CH2OR5, —OCH2CO2R5, —CH2SR5, —CH2NR5R6, —SR5, —OSR5, or —NR5SO2R6, where R5 and R6 are each independently hydrogen, substituted or unsubstituted (C1-C5) alkyl, (C2-C5) alkenyl, or (C2-C5) alkynyl, or a cycloType: GrantFiled: December 5, 2006Date of Patent: January 6, 2009Assignee: The Trustees of Columbia University in the City of New YorkInventors: Kristian Stromgaard, Makiko Suehiro, Koji Nakanishi, Stine B. Vogensen
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Publication number: 20080299674Abstract: Novel isonitrile compounds represented by the general formula F-A-NC, their method of manufacture, a marine fouling organism larva fluorescent marker having at least one of these compounds as an active ingredient, and a method of detecting this marine fouling organism larva using this marker. F in the aforesaid general formula represents a fluorescent functional group, and A represents a linking chain.Type: ApplicationFiled: June 2, 2005Publication date: December 4, 2008Inventors: Yoshikazu Kitano, Isamu Sakaguchi, Yasuyuki Nogata, Kiyotaka Matsumura
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Publication number: 20080274893Abstract: The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y, Z and R3 are as defined above, to processes and intermediates for their preparation and to their use as pesticides, microbicides and herbicides.Type: ApplicationFiled: July 8, 2008Publication date: November 6, 2008Inventors: Reiner Fischer, Astrid Ullmann, Thomas Bretschneider, Mark Wilhelm Drewes, Christoph Erdelen, Angelika Lubos-Erdelen, Dieter Feucht, Udo Reckmann
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Patent number: 7442809Abstract: A method for producing a 1,3-dioxan-4,6-dione compound from a ketone compound and a malonic acid, the method comprising: precipitating a 1,3-dioxan-4,6-dione compound as a crystal from a mixed solvent comprising a first organic solvent having a dielectric constant of 10 or more and a water, so as to form a precipitated 1,3-dioxan-4,6-dione compound; and isolating the precipitated 1,3-dioxan-4,6-dione compound by a solid-liquid separation.Type: GrantFiled: May 31, 2005Date of Patent: October 28, 2008Assignee: FUJIFILM CorporationInventors: Shingo Sato, Hideto Mori
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Publication number: 20080254498Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.Type: ApplicationFiled: February 29, 2008Publication date: October 16, 2008Applicant: ABD Bioquest, Inc.Inventors: Zhenjun Diwu, Jianjun He, Jinfang Liao
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Patent number: 7429670Abstract: The subject invention provides ginkgolide C derivatives compounds having the structure: wherein R is H or -A-Ar, where A is an alkyl group; and Ar is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH2CO2R4, and —CH2CONR5R6; where R4 is an alkyl group; and R5 and R6 are each, independently, hydrogen or a branched or unbranched alkyl group; wherein R1 is H or —COR7, where R7 is alkyl, aryl or amino; wherein R2 is present or absent, and when present is H, —COR8 or —CO—Z—R8; where R8 is alkyl, aryl or amino; and Z is oxygen; wherein R3 is present or absent, and when present is —COR9; where R9 is alkyl or aryl; wherein only one of R2 or R3 is present in the compound; wherein only two of R, R1, R2 and R3 are H; and wherein each of a and b designates a single covalent bond which is present or absent, where bond a is present when R3 is absent and bond b is present when R2Type: GrantFiled: August 24, 2004Date of Patent: September 30, 2008Assignee: The Trustees of Columbia University in the City of New YorkInventors: Koji Nakanishi, Stanislav Jaracz, Kristian Stromgaard
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Patent number: RE41366Abstract: The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom, R2=a hydroxy group, R1 and R2 together form ?O, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2)alkoxy group, R6?H, (C1-C12)alkyl, (CH2)nNR7R8, or —(CH2)nN+R7R8R9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group.Type: GrantFiled: June 14, 2002Date of Patent: June 1, 2010Assignee: Centre National del la Recherche Scientifique (CNRS)Inventors: Claude Thal, Catherine Guillou, Jean-Luc Beunard, Emmanuel Gras, Pierre Potier