The Lactone Ring Is Five-membered Patents (Class 549/295)
  • Patent number: 6362346
    Abstract: This invention pertains to a process for making &agr;-methylene-&ggr;-butyrolactone by acid-catalyzed rearrangement of tetrahydro-3-furoic acid. In a further embodiment, when tetrahydro-3-furoic acid is treated with acetic anhydride and an acid catalyst, &agr;-acetoxymethyl-&ggr;-butyrolactone is produced in high yield. Under basic conditions, &agr;-acetoxymethyl-&ggr;-butyrolactone can readily form&agr;-methylene-&ggr;-butyrolactone by the elimination of acetic acid. These reactions provide &agr;-methylene-&ggr;-butyrolactone by novel routes which do not require butyrolactone or formaldehyde.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: March 26, 2002
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Dale Robert Coulson, David L. Thorn, Mark A. Scialdone
  • Publication number: 20020032230
    Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
    Type: Application
    Filed: May 21, 2001
    Publication date: March 14, 2002
    Applicant: DR. REDDY'S LABORATORIES LTD.
    Inventors: Manojit Pal, Koteswar Rao Yeleswarapu, Rajagopalan Ramanujam, Parimal Misra, Prem Kumar Mamnoor, Seshagiri Rao Casturi
  • Patent number: 6350775
    Abstract: A compound of formula (I): wherein R1 is hydroxy or of the formula —NHC(═O)(1-4C)alkyl or —NHS(O)n(1-4C)alkyl wherein n is 0, 1 or 2; R2 and R3 are independently hydrogen or fluoro; R4 and R5 are independently hydrogen or methyl; >A—B— is of the formula >C═CH—, or >C(OH)CH2—; >X—Y— is of the formula >C=CH—, or >CHCH2—; and D is S, SO, or SO2; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: February 26, 2002
    Assignee: Zeneca Limited
    Inventor: Michael Barry Gravestock
  • Publication number: 20020019545
    Abstract: Lactone compounds of formula (1) are useful as monomers to form base resins for use in chemically amplified resist compositions adapted for micropatterning lithography.
    Type: Application
    Filed: May 31, 2001
    Publication date: February 14, 2002
    Applicant: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeshi Kinsho, Koji Hasegawa, Takeru Watanabe, Tsunehiro Nishi, Mutsuo Nakashima, Seiichiro Tachibana, Jun Hatakeyama
  • Patent number: 6346629
    Abstract: Process for producing butyrolactones of the general formula I where R1 and R2 are each hydrogen, alkyl, hydroxyalkyl, substituted or unsubstituted aryl or substituted or unsubstituted trialkylsilyl, by reacting alkynes of the general formula II where R1 and R2 are each as defined above, with carbon monoxide and water in the presence of a rhodium catalyst under pressures from 20 to 300 bar and hydrogenating the unhydrogenated 2(5H)-furanone intermediates comprises a) reacting the carbonylation reaction mixture with hydrogen at from 150 to 250° C. and from 100 to 300 bar, b) removing the precipitated catalyst and returning it into the carbonylation reaction, and c) subjecting the catalyst-free reaction mixture to a distillation to recover the butyrolactone.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: February 12, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Melanie Brunner, Ralf-Thomas Rahn, Udo Rheude, Jochem Henkelmann
  • Publication number: 20020016477
    Abstract: Lactone compounds of formula (1) are novel and useful as monomers to form base resins for use in chemically amplified resist compositions adapted for micropatterning lithography.
    Type: Application
    Filed: July 5, 2001
    Publication date: February 7, 2002
    Applicant: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeshi Kinsho, Takeru Watanabe, Koji Hasegawa, Tsunehiro Nishi, Matsuo Nakashima, Seiichiro Tachibana, Jun Hatakeyama
  • Patent number: 6323347
    Abstract: The present invention relates to a catalyst for preparing a lactone, which is prepared by supporting a cupric compound, a zinc compound and at least one alkaline earth metal compound on the supporter. The present invention also relates to a method for preparing a lactone, which comprises a dehydrocyclization reaction of a diol under a gas phase in the presence of the aforementioned catalyst after activating said catalyst. The catalyst for preparing lactone of the present invention is quite economic because of its high activity, long lifetime and high selectivity of products.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: November 27, 2001
    Assignee: Dairen Chemical Corporation
    Inventors: Shien-Chang Chen, Fu-Shen Lin, Liang-An Hsu, Cheng-Lin Tsai
  • Patent number: 6313318
    Abstract: This invention concerns a process for the addition of formaldehyde to the &agr; carbon atom of lactones for the production of &agr;-methylenelactones, and specifically &agr;-methylene-&ggr;-butyrolactone.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: November 6, 2001
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Dale Robert Coulson, Leo E. Manzer, Norman Herron
  • Patent number: 6299736
    Abstract: Gamma-Butyrolactone (GBL) is recovered from a mixture containing GBL and other heavy organics by a process of azeotropic distillation in the presence of a C8-C 10 hydrocarbon as an azeotroping agent, wherein an azeotrope of GBL and the hydrocarbon is obtained as a distillate, which forms immiscible GBL-rich and hydrocarbon-rich phases, and the hydrocarbon-rich phase is decanted or isolated from the GBL-rich phase. By this process GBL can be efficiently separated from a large proportion of various compounds having boiling points close to that of GBL, e.g., the methyl-&ggr;-butyrolactones (MeGBL's).
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: October 9, 2001
    Assignee: Celanese International Corporation
    Inventors: Kenneth A. Windhorst, H. Robert Gerberich, Deborah A. Sitz, Nicole Garrett-Wallace, R. Jay Warner
  • Patent number: 6297274
    Abstract: Novel nonpeptide endothelin I antagonists of Formula are described wherein R1 is unsubstituted or substituted cycloalkyl, phenyl, naphthyl or heteroaryl, R2 is unsubstituted or substituted alkyl, aryl or heteroaryl, R3 is unsubstituted or substituted alkyl, cycloalkyl, aryl or heteroayl, and R1 and/or R2 and/or R3 are independently substituted by a total of from 1 to 4 substituents which enhance aqueous solubility with the proviso that when R2 is alkyl and is substituted, the substituent is not oxygen at the &agr;-position of the furanone ring.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: October 2, 2001
    Assignee: Warner-Lambert Company
    Inventors: Xue-Min Cheng, Annette Marian Doherty, William Chester Patt, Joseph Thomas Repine
  • Patent number: 6297389
    Abstract: A process for the production of gamma-butyrolactone. Starting from maleic and/or succinic anhydride the conversion takes place in the presence of a catalyst composed of copper oxide and zinc oxide.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: October 2, 2001
    Assignee: Lonza S.p.A.
    Inventors: Gian L Castiglioni, Carlo Fumagalli
  • Patent number: 6288268
    Abstract: A catalyst for the bisalkoxycarbonylation of olefins comprising a noble metal compound and a phosphine chalcogenide of the following formula (1): wherein each of R1, R2 and R3 is, independently, an alkyl group or an aryl group each of which may have a substituent, and A is a Group 16 element of the Periodic Table; and R1, R2 or R3 may be combined, directly or through a bridging group, with one another where the groups to be combined may be attached either to an identical phosphorus atom or to different phosphorus atoms. Element A includes oxygen, sulfur and selenium atoms. The noble metal compound includes palladium(II) halides and other palladium compounds. The catalyst may further include a copper(I) halide or other copper compound as a co-catalyst. The use of this catalyst can provide the bisalkoxycarbonylation of olefins with efficiency.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: September 11, 2001
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Kazuhiko Saigo, Yukihiko Hashimoto, Minoru Hayashi
  • Patent number: 6288244
    Abstract: A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-&ggr;-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-&ggr;-butyrolactone from a 3-leaving group substituted L-pentose sugars. The process uses a base and a peroxide to convert the pentose source to the chiral 3,4-dihydroxybutanoic acid compound. The chiral 3,4-dihydroxybutanoic acid can be further converted to 3-hydroxy-&ggr;-butyrolactone by acidification. The chiral compound is useful as a chemical intermediate to the synthesis of various drugs and other products.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: September 11, 2001
    Assignee: Board of Trustees operating Michigan State University
    Inventor: Rawle I. Hollingsworth
  • Patent number: 6274743
    Abstract: Butane-1,4-diol, gamma-butyrolactone or tetrahydrofuran are prepared by vapor phase hydrogenation of a C4-dicarboxylic acid derivative. A maleic anhydride containing vapor stream is contacted in an absorption zone with a first high boiling solvent. A waste gas stream is passed to a scrubbing zone containing a second, higher boiling solvent. The waste gas is purged and the first and second solvents are recovered and recycled. Maleic anhydride is obtained from the absorption zone and converted to a maleic acid diester, which is stripped from the first solvent with hydrogen. The desired products are obtained by hydrogenation.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: August 14, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael W. M. Tuck, Philip H. D. Eastland, Andrew G. Hiles, Graham Reed
  • Publication number: 20010009964
    Abstract: The present invention relates to a catalyst for preparing a lactone, which is prepared by supporting a cupric compound, a zinc compound and at least one alkaline earth metal compound on the supporter. The present invention also relates to a method for preparing a lactone, which comprises a dehydrocyclization reaction of a diol under a gas phase in the presence of the aforementioned catalyst after activating said catalyst. The catalyst for preparing lactone of the present invention is quite economic because of its high activity, long lifetime and high selectivity of products.
    Type: Application
    Filed: December 15, 2000
    Publication date: July 26, 2001
    Applicant: DAIREN CHEMICAL CORPORATION
    Inventors: Shien-Chang Chen, Fu-Shen Lin, Liang-An Hsu, Cheng-Lin Tsai
  • Patent number: 6258963
    Abstract: The invention relates to modified benzylidene-&ggr;-butyrolactones, to a process for their preparation and to the use as UV absorber, for example in pharmaceutical and cosmetic compositions, sunscreens, daycare and haircare products, for improving industrial products, such as paints, surface coatings, plastics, textiles, packaging materials and rubbers.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: July 10, 2001
    Assignee: Haarmann & Reimer GmbH
    Inventors: Oskar Koch, William Johncock, Roland Langner
  • Patent number: 6245920
    Abstract: Noble metal, particularly ruthenium, Raney catalysts which can hydrogenate (1) aromaticity-exhibiting ring portions of organic compounds, (2) carboxylic acids and their ester portions (carbonyl ester groups), (3) ring portions and carboxylic acid or their ester groups in compounds having such ring portions and carboxylic acid or their ester portions, and (4) ring portions and nitrile groups of aromatic nitrile compounds and methods for the preparation of corresponding hydrogenated compounds. The methods allow preparation of hydrogenated compounds having hydrogenated aromatic ring portions, hydrogenated carbonyl ester groups, hydrogenated aromatic ring and carbonyl ester groups, or hydrogenated aromatic rings and nitrile groups under milder hydrogen pressure and temperature conditions than the conventional catalysts.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: June 12, 2001
    Assignee: Showa Denko K.K.
    Inventors: Kouhei Morikawa, Shuuji Hirayama, Yoshimasa Ishimura, Yuseki Suyama, Tsutomu Nozawa, Hiroyuki Monzen, Motoo Miura, Kuniomi Marumo, Taketoshi Naito
  • Patent number: 6235930
    Abstract: A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-&ggr;-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic acid and (R)-3-hydroxy-&ggr;-butyrolactone from a 3-leaving group substituted L-pentose sugars. The process uses a base and a peroxide to convert the pentose source to the chiral 3,4-dihydroxybutanoic acid compound. The chiral 3,4-dihydroxybutanoic acid can be further converted to 3-hydroxy-&ggr;-butyrolactone by acidification. The chiral compound is useful as a chemical intermediate to the synthesis of various drugs and other products.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: May 22, 2001
    Assignee: Board of Trustees operating Michigan State University
    Inventor: Rawle I. Hollingsworth
  • Patent number: 6232474
    Abstract: This invention pertains to a process for making &agr;-methylenelactones and &agr;-substituted hydrocarbylidene lactones. The present invention obtains high yields of &agr;-methylene-&ggr;-butyrolactone by heating &ggr;-butyrolactone and formaldehyde in the presence of a base.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: May 15, 2001
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Charles Brandenburg, Randal King, Leo E. Manzer
  • Patent number: 6229023
    Abstract: According to the inventive co-oxidation process of organic compounds, (A) a compound selected from (A1) a compound having a non-aromatic ethylenic bond and (A2) a ketone or an alcohol corresponding to the ketone is oxidized by molecular oxygen in the presence of N-hydroxyphthalimide or another imide compound and in the coexistence of (B) a compound oxidizable by the imide compound and oxygen and different from the compound (A). As the compound (B), (a) primary or secondary alcohols (e.g., benzhydrol, cyclohexanol), (b) compounds each having a carbon-hydrogen bond at the adjacent position to an unsaturated bond (e.g., tetralin, ethylbenzene) and the like can be used. According to this process, a corresponding epoxy compound from the compound (A1) having a non-aromatic ethylenic bond, and a corresponding ester or lactone from the ketone or its corresponding alcohol (A2) can be obtained in satisfactory yields.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: May 8, 2001
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Yasutaka Ishii, Tatsuya Nakano
  • Patent number: 6225476
    Abstract: Provided by the invention is a chemical-amplification positive-working photoresist composition used in the fine photolithographic patterning in the manufacturing process of semiconductor devices, which is suitable for the patterning light exposure with ArF excimer laser beams of very short wavelength by virtue of absence of aromatic structure in the ingredients of the composition. The composition comprises, as the film-forming resinous ingredient, an acrylic resin having unique monomeric units represented by the general formula &Brketopenst;CH2—CR1(—CO—O—CR2R3R4)&Brketclosest;, in which R1 is a hydrogen atom or a methyl group, R2 and R3 are each, independently from the other, an alkyl group having 1 to 4 carbon atoms and R4 is an alkoxycarbonyl group or a group derived from a molecule of a lactone compound or ketone compound by removing a hydrogen atom bonded to the carbon atom.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: May 1, 2001
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Hideo Hada, Kazufumi Sato, Hiroshi Komano
  • Patent number: 6222048
    Abstract: The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: April 24, 2001
    Assignee: Merck Frosst Canada & Co.
    Inventors: Cameron Black, Erich Grimm, Serge Leger, Petpiboon Prasit, Zhaoyin Wang
  • Patent number: 6187965
    Abstract: A method of recovering benzyl alcohol, gamma butyrolactone, or propylene carbonate from an impure effluent stream of an industrial process is provided. The effluent waste stream contains greater than about 10 percent by weight of monomeric units that are reacted to form larger oligomers and polymers. The first step in the recovery process involves polymerizing the monomeric units present in the effluent waste stream under conditions effective to reduce the concentration of monomeric units in the waste stream to less than about 10 weight percent. The waste stream then is fed to a first separation stage where it is separated into (i) a gaseous stream of water, soluble gases, and volatile contaminants and (ii) a suspension comprising the high boiling solvent, semi-volatile materials, and non-volatile contaminants and materials. Then the dewatered, low vapor pressure, high boiling solvent-containing suspension is either distilled or evaporated to separate the high boiling solvent from non-volatile materials.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: February 13, 2001
    Assignee: International Business Machines Corporation
    Inventors: Anilkumar C. Bhatt, Jerome J. Wagner
  • Patent number: 6160132
    Abstract: This invention relates to matrix metalloproteinase (MMP) inhibiting compounds of the formula: ##STR1## where R.sup.1 is C.sub.1 -C.sub.12 alkyl, straight or branched and optionally substituted by halogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, amino, carboxyl, C.sub.1 -C.sub.6 alkoxycarbonyl, carboxamido, nitrile, mono- or di-(C.sub.1 -C.sub.6)alkylamino, thio, C.sub.1 -C.sub.6 alkylthio, aryl, --Oaryl or --OCH.sub.2 aryl where aryl is optionally substituted with C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, carboxy, halogen, cyano, nitro, carboxamido, or hydroxy; and C.sub.1 -C.sub.6 alkanesulfonyloxy. R.sup.2 is .alpha.-OH or .beta.-OH and R.sup.6 is H or R.sup.2 and R.sup.6 together are carbonyl; the chemical intermediates; and processes for the preparation of these compounds and the intermediates thereto.Matrix metalloproteinases (MMP) are a family of zinc-containing calcium dependent proteinases, including stromelysins, collagenases, and gelatinases.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: December 12, 2000
    Assignee: American Cyanamid Company
    Inventor: Jeremy Ian Levin
  • Patent number: 6127553
    Abstract: The invention relates to a process for the isolation of Hibiscus acid or (+)hydroxycitric acid lactone (2S,3R-dihydroxy-1,2,3-propanetricarboxylic acid lactone) from the leaves of Hibiscus furcatus, Hibiscus sabdariffa and Hibiscus cannabinus. Garcinia acid, one of the optical isomers of hydroxycitric acid is a potentially interesting molecule and found extensive application in the pharmacological as well as synthetic fronts.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: October 3, 2000
    Assignee: Department of Science and Technology, Goverment of India
    Inventors: Ibrahim Ibnusaud, Rani Rajasekharan, Teena Philip, Salini Thomas
  • Patent number: 6127552
    Abstract: A process is disclosed for producing (R)-3-hydroxy-4-butyrolactone from its enantiomer, (S)-3-hydroxy-4-butyrolactone. The (R)-enantiomer can be advantageously utilized in several organic synthesis and industrial processes, such as e.g. GABOB and (R)-carnitine preparation.
    Type: Grant
    Filed: November 30, 1998
    Date of Patent: October 3, 2000
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Maria Ornella Tinti, Francesco De Angelis
  • Patent number: 6110520
    Abstract: A process for producing high yields of .gamma.-hexalactone and 2-pentanone from the corresponding hexanoic acid starting material is carried out with high amounts of oxygen and sugar in the presence of a mold microorganism. Fragrance compositions and foodstuff compositions are augmented and enhanced by the presence of the product compounds.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: August 29, 2000
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Fenjin He, Mohamad I. Farbood, Laura E. Kizer
  • Patent number: 6087138
    Abstract: The present invention relates to a process for the preparation of a composition rich in sotolon from a source rich in 4-hydroxy-L-iso-leucine.
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: July 11, 2000
    Assignee: Unilever Patent Holdings BV
    Inventors: Amir Maximiliaan Batenburg, Johannes Jan Wesdorp
  • Patent number: 6077964
    Abstract: A process is described for the production of at least one C.sub.4 compound selected from butane-1,4-diol, .gamma.-butyrolactone and tetrahydrofuran, which includes the step of hydrogenation in the vapour phase of maleic anhydride in the presence of a heterogeneous hydrogenation catalyst, which process comprises:(a) contacting a vaporous stream containing maleic anhydride vapour, water vapour, and carbon oxides in an absorption zone with a high boiling organic solvent having a boiling point at atmospheric pressure which is at least about 30.degree. C.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: June 20, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael William Marshall Tuck, Michael Anthony Wood, Andrew George Hiles
  • Patent number: 6060046
    Abstract: An antifouling composition that comprises an effective amount of a furanone of the structure shown and a suitable carrier therefor. In the figure, substituents R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen atom, a hydroxyl group, an alkyl group containing from 1 to 10 carbon atoms, an ether group containing from 1 to 10 carbon atoms, an ester group containing from 1 to 10 carbon atoms or a halogenated alkene containing from 1 to 10 carbon atoms or R.sub.2 and R.sub.3 together may comprise an unsubstituted or a halogenated alkene containing from 1 to 10 carbon atoms and R.sub.4 is a hydrogen or halogen atom, and a suitable carrier therefor.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: May 9, 2000
    Assignee: Unisearch Limited
    Inventors: Peter D. Steinberg, Peter C. De Nys
  • Patent number: 6034255
    Abstract: The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: March 7, 2000
    Assignee: University of New Mexico
    Inventors: Lorraine Deck, David L. Vander Jagt
  • Patent number: 6001781
    Abstract: The present invention is directed to a process for preparing a condensation product of a glyoxylic reactant and a hydrocarbyl-substituted aromatic compound having at least one hydroxy functionality, which includes (a) providing the glyoxylic reactant in the form of a compound represented by the formula ##STR1## or its reactive equivalent, wherein R.sup.1 and R.sup.3 independently are hydrogen or hydrocarbyl group of 1 to about 4 carbon atoms; and R.sup.2 and R.sup.4 independently are hydrocarbyl groups of 1 to about 4 carbon atoms; (b) mixing the aromatic compound with the glyoxylic reactant; and (c) heating the mixture to a temperature of about 50.degree. C. to about 200.degree. C. in the presence of an acid catalyst for a sufficient time to form the condensation product.
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: December 14, 1999
    Assignee: The Lubrizol Corporation
    Inventors: Mark R. Baker, Karen M. Hull, David L. Westfall
  • Patent number: 5998468
    Abstract: Novel nonpeptide antagonists of endothelin (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prostatic hyperplasia (BPH), and diabetes.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: December 7, 1999
    Assignee: Warner-Lambert Company
    Inventors: Xue-Min Cheng, Annette Marian Doherty, William Chester Patt, Joseph Thomas Repine
  • Patent number: 5994597
    Abstract: A method of recovering solvents from an impure effluent stream of an industrial process. The effluent waste stream contains less than about 10 percent by weight of monomeric units that are reacted to form larger oligomers and polymers. The waste stream contains dissolved polymers, polymeric particles, and the hydrolysis, oxidation and/or other decomposition products of one of the solvents. In one embodiment, the first step involves filtering particulate matter from the waste stream. In another embodiment, the filtering step is omitted. The filtered or unfiltered waste stream is fed to a first separation stage for separation into (i) a gaseous stream of water, soluble gases, and volatile contaminants and (ii) a suspension comprising the solvent, water, semi-volatile and non-volatile contaminants, and photoresist products.
    Type: Grant
    Filed: November 6, 1998
    Date of Patent: November 30, 1999
    Assignee: International Business Machines Corporation
    Inventors: Anilkumar C. Bhatt, Jerome J. Wagner
  • Patent number: 5981577
    Abstract: A compound of formula I, ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.1 ', R.sub.2 ', and R.sub.3 ' are independently the same or different and each represent hydrogen, hydroxy, or lower alkoxy, or any vicinal two of R.sub.1, R.sub.2, R.sub.3, R.sub.1 ', R.sub.2 ', and R.sub.3 ' combined together represent --O--(CH.sub.2).sub.n --O--, wherein n=1 or 2; R.sub.4 represents methylene or halomethyl; and X.sub.1, X.sub.2, X.sub.3, and X.sub.4 are independently the same or different and each represent hydrogen or halogen; or a pharmaceutically acceptable salt thereof. Also disclosed are a pharmaceutical composition that contains an effective amount of a compound of formula I together with a pharmaceutically acceptable excipient, and a method of treating cancer that involves the administration of an effective amount of the compound of formula I to a patient in need thereof.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: November 9, 1999
    Assignee: Development Center for Biotechnology
    Inventors: Shan-Yen Chou, Shan-Shue Wang, Han-Jung Tsai, Shyh-Fong Chen, Hou Ku
  • Patent number: 5972237
    Abstract: Heterocyclic compounds IR.sup.1 --X--L (I)whereL is a cyclic carbamate residue, a lactonoxy residue or a lactam residue,X is an oxygen-containing group ##STR1## where A is a linker, and R.sup.1 is an organic radical or a group L,are used as activators for inorganic peroxy compounds, in particular as cold bleach activators or optical brighteners in detergents, cleaners and bleaches and in disinfectants.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: October 26, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Reinhard Muller, Thomas Wehlage, Wolfgang Trieselt, Alfred Oftring, Elisabeth Kappes, Gunter Oetter, Dieter Boeckh, Roland Ettl, Albert Hettche
  • Patent number: 5962700
    Abstract: A process for the preparation of butyrolactones of the formula I ##STR1## where the substituents R.sup.1 and R.sup.2 are hydrogen, alkyl or hydroxyalkyl groups, or aryl and trialkylsilyl groups, if appropriate carrying inert: substituents, is described in which an alkyne of the formula IIR.sup.1 --C.tbd.C--R.sup.2 IIwhere the substituents have the meanings indicated above, is reacted under reducing conditions at elevated pressure and elevated temperature with carbon monoxide CO and hydrogen in the presence of a transition metal catalyst or with carbon monoxide and water in the presence of a transition metal catalyst.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: October 5, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Marc Heider, Thomas Ruhl, Jochem Henkelmann, Susanne Stutz, Thomas Preiss, Heinz Rutter, Martin Schafer, Arthur Hohn
  • Patent number: 5955620
    Abstract: A process for dehydrogenating 1,4-butanediol to .gamma.-butyrolactone in the gas phase in the presence of a copper-containing catalyst, wherein the catalyst contains 4-40% by weight of copper and 0-5% by weight of Na.sub.2 O, based on the total weight of the catalyst, on a carrier consisting of 80-100% by weight of SiO.sub.2 and 0-20% by weight of CaO.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: September 21, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans Jochen Mercker, Frank-Friedrich Pape, Joachim Simon, Andreas Henne, Michael Hesse, Ulrich Kohler, Roman Dostalek, Cristina Freire Erdbrugger, Detlef Kratz
  • Patent number: 5945547
    Abstract: The compound 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate is described and claimed.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath
  • Patent number: 5912361
    Abstract: Trehalose is oxidized to give oxidized trehalose which then is hydrolyzed to produce D-glucuronolactone which is thereafter recovered to realize high-yield and low-cost production of D-glucuronolactone.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: June 15, 1999
    Assignees: Chugoku Kayaku Kabushiki Kaisha, Hayashibara Biochemical Laboratories, Inc.
    Inventors: Toshiki Tsuchioka, Tadashi Yamaguchi, Kunihiko Yuuen, Hiroto Chaen
  • Patent number: 5912360
    Abstract: The present invention relates to intermediates, useful for the preparation of therapeutically active hydroxamic acid derivatives which are inhibitors of metalloproteinases involved in tissue degradation, and are inhibitors of the release of tumour necrosis factor from cells.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: June 15, 1999
    Assignee: British Biotech Pharmaceuticals Limited
    Inventor: Jonathan Philip Dickens
  • Patent number: 5849217
    Abstract: An optically active compound represented by the formula R.sub.1 --A.sub.1 --A.sub.2 --X.sub.1 --A.sub.3 --(CH.sub.2).sub.p --L--A.sub.4 --R.sub.2, in which R.sub.1 is F, CN or straight chain, branched or cyclic alkyl and R.sub.2 is H, F, CH or straight chain or branched alkyl; A.sub.3 is 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl, pyrazine-2,5-diyl, pyridazine-3,6-diyl, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,3-ditiane-2,5-diyl, thiophene-2,5-diyl, thiazole-2,5-diyl, thiaziazole-2,5-diyl, benzoxazole-2,5-diyl, benzoxazole-2,6-diyl, benzothiazole-2,5-diyl, benzothiazole-2,6-diyl, benzofuran-2,5-diyl, benzofuran-2,6-diyl, quinoxaline-2,6-diyl, quinoline-2,6-diyl, 2,6-naphthylene, indane-2,5-diyl, 2-alkylindane-2,5-diyl, indanone-2,6-diyl, 2-alkylindane-2,6-diyl, coumarane-2,5-diyl and 2-alkylcoumarane-2,5-diyl; A.sub.1, A.sub.2 and A.sub.4 are single bond or A.sub.3 ; X.sub.1 ' is a single bond, --COO--, --OCO--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: December 15, 1998
    Assignee: Canon Kabushiki Kaisha
    Inventors: Shinichi Nakamura, Takao Takiguchi, Takashi Iwaki, Takeshi Togano, Yoko Kosaka
  • Patent number: 5840920
    Abstract: A process for reacting olefinic compounds, certain carboxylic reactants, and aldehydes or ketones and products prepared by the process. The compositions of the process are useful as intermediates for the preparation of additives for lubricants and fuels.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: November 24, 1998
    Assignee: The Lubrizol Corporation
    Inventor: Mark R. Baker
  • Patent number: 5767291
    Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: June 16, 1998
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Yves Ducharme, Jacques Yves Gauthier, Petpiboon Prasit, Yves Leblanc, Zhaoyin Wang, Serge Leger, Michel Therien
  • Patent number: 5741955
    Abstract: This invention concerns processes for the reductive hydrolysis of nitriles to alcohols utilizing as a catalyst a transition metal complex of the formula MHZ(CO)L.sub.n (PR.sub.3).sub.2 wherein: M is a transition metal selected from the group consisting of: Fe, Ru and Os; Z is an anionic ligand; L is a neutral ligand; n is 0 or 1; and PR.sub.3 is a phosphine ligand.
    Type: Grant
    Filed: October 17, 1995
    Date of Patent: April 21, 1998
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Richard Paul Beatty
  • Patent number: 5714618
    Abstract: A polymer having a blocked terminal group according to the present invention, represented by the following Formula (I): ##STR1## where R is an alkylene group containing 1 to 20 carbon atoms; X.sub.1 is an acyl group containing 2 to 50 carbon atoms; Y is H, an alkyl group containing 1 to 50 carbon atoms or an alkenyl group containing 1 to 50 carbon atoms; m is a positive integer; and n.sub.1 is 0 or a positive integer.
    Type: Grant
    Filed: January 9, 1997
    Date of Patent: February 3, 1998
    Assignee: Toyo Boseki Kabushiki Kaisha
    Inventors: Kunio Kimura, Takeshi Ito, Tomohiro Aoyama, Keiichi Uno, Kiyoshi Hotta, Minako Arichi
  • Patent number: 5698514
    Abstract: Described are allyl esters of 2-norbornane acrylic acids and 2-norbornylidene propionic acids defined according to the generic structure: ##STR1## wherein the wavy line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein one of the dashed lines is carbon-carbon single bond and the other of the dashed lines is a carbon-carbon double bond; and wherein R represents methyl or hydrogen; as well as methods for augmenting or enhancing the aroma of consumable materials including perfumes, colognes and perfumed articles.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: December 16, 1997
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Wilhelmus Johannes Wiegers, Marie R. Hanna
  • Patent number: 5670661
    Abstract: The present invention relates to a process for producing lactones starting from cyclic ketones which comprises an oxidation reaction which is performed in the presence of an optionally substituted cycloaliphatic peracid or of an optionally substituted aliphatic peracid that is immiscible with water. The process allows to obtain high selectivity, does not entail the use of dangerous reagents, and allows excellent economic advantages.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: September 23, 1997
    Assignee: Industrie Chimiche Caffaro S.p.A.
    Inventors: Livius Cotarca, Roberto Bianchini
  • Patent number: 5665891
    Abstract: A process for the catalysed oxidation of ketones to esters or lactones with hydrogen peroxide in the presence of a carboxylic acid or anhydride is provided. The process employs gamma alumina as a heterogeneous catalyst. In certain preferred embodiments the catalyst also contains a tungsten-containing heteropolyacid. Preferably, the heteropolyacid contains phosphorus. In a related process, the catalyst accelerates the formation of percarboxylic acid solutions.
    Type: Grant
    Filed: October 12, 1995
    Date of Patent: September 9, 1997
    Assignee: Solvay Interox Limited
    Inventors: Scott William Brown, Alexander Johnstone, William Ronald Sanderson
  • Patent number: 5646098
    Abstract: The invention relates to novel compositions comprising ene and free radical adducts of unsaturated and saturated hydrocarbons, and acyclic and cyclic vicinal polycarbonyl compounds such as diethyl ketomalonate and indantrione. The adducts are reacted with nucleophiles such as amines, electrophiles such as anhydrides and esters, and metal ions. Post-products are obtained via reaction of said products with capping reagents such as boric acid. Compositions containing said adducts, products and post-products include oleaginous substances such as fuels and lube oils.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: July 8, 1997
    Assignee: Exxon Chemical Patents Inc
    Inventor: Stanley J. Brois