Plural Ring Oxygens In The Hetero Ring Patents (Class 549/347)
  • Patent number: 10897045
    Abstract: A crosslinked polymer composition comprising: (i) a base polymer containing a multiplicity of at least one type of functional group selected from amino, amido, thiol, carboxylic acid, carboxylic acid ester, and epoxy groups; (ii) a multiplicity of hydroxylated benzene rings covalently linked to the base polymer, wherein each hydroxylated benzene ring contains at least two hydroxy groups, and with at least two of the hydroxy groups on said hydroxylated benzene rings being free as OH groups; and (iii) a multiplicity of crosslinking groups that crosslink at least two of said functional groups in the base polymer. The invention is also directed to lithium-ion batteries in which the above-described composition is incorporated in an electrode of the battery, and also directed to methods of operating a lithium-ion battery in which the above-described crosslinked polymer composition is incorporated in an electrode thereof.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 19, 2021
    Assignee: UT-Battelle, LLC
    Inventors: Tomonori Saito, Pengfei Cao, Jagjit Nanda
  • Patent number: 10501607
    Abstract: Polyphase biodegradable compositions having a good resistance to ageing comprising a continuous phase comprising at least one hydrophobic polyester and at least one dispersed phase of polymer of vegetable origin. The hydrophobic polyester constituting the continuous phase is incompatible with the polymer of vegetable origin. The compositions comprise a plasticiser comprising at least 75% of a mixture of diglycerol, triglycerol and tetraglycerol.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: December 10, 2019
    Assignee: NOVAMONT S.P.A.
    Inventor: Luigi Capuzzi
  • Patent number: 10138321
    Abstract: The invention provides a method for producing an oxymethylene copolymer including a polymerization step for cationically polymerizing trioxane and a comonomer at a polymerization temperature of from 135 to 300° C. in the presence of at least one salt of a protonic acid having a molecular weight of 1,000 or less, and at least one polymerization initiator selected from the group consisting of protonic acids having a molecular weight of 1,000 or less, protonic acid anhydrides having a molecular weight of 1,000 or less, and protonic acid ester compounds having a molecular weight of 1,000 or less; wherein the total concentration of metal components contained in the trioxane and comonomer used in the polymerization step is 300 ppb by mass or less.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: November 27, 2018
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Daigo Nakaya, Toru Takahashi, Satoshi Mochida, Kensuke Oshima
  • Patent number: 8927596
    Abstract: An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): where C represents an alicyclic hydrocarbon ring group which may be substituted, and n represents an integer of 1 to 6.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 6, 2015
    Assignee: National University Corporation Okayama University
    Inventors: Yusuke Wataya, Hye-Sook Kim, Akiko Hiramoto, Akira Sato, Nobuo Ota, Takashi Kumagai, Rieko Shimogawara, Toshie Taniguchi
  • Patent number: 8912365
    Abstract: The present invention relates to a process for preparing a polyol ether of formula (I), comprising a step of reductive alkylation involving a compound of general formula (II) and a compound of general formula (III): in which R1, R2, R3 and R4 are as defined in claim 1.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 16, 2014
    Assignees: Fonds de Developpement des Filieres des Oleagineux et Proteagineux Fidop, Centre National de la Recherche Scientifique
    Inventors: Marc Lemaire, Wissam Dayoub, Marc Sutter, Yann Raoul
  • Publication number: 20140330029
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 6, 2014
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Patent number: 8835462
    Abstract: The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: September 16, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Kevin G. Meyer, W. John Owen, James M. Renga, Chenglin Yao, Benjamin M. Nugent, Jeremy Wilmot, Fangzheng Li, Karla Bravo-Altamirano
  • Patent number: 8829206
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 9, 2014
    Assignee: Eastman Chemical Company
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20130331323
    Abstract: A compound for controlling blood glucose level has a structure shown in Formula I: wherein R5-R8 are as defined herein. A method for controlling blood glucose level includes administering to a subject in need thereof a compound of Formula I. The method further includes administering to the subject a GLP-1 receptor ligand. The compound and the GLP-1 receptor ligand may be administered together. The compound may be Galanal A or Galanal B. The GLP-1 receptor ligand may be GLP-1 or exendin-4.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 12, 2013
    Applicant: Development Center for Biotechnology
    Inventors: Rey-Yuh Wu, Hui-Ling Chen, Yu-Yuan Wu, Jiann-Jyh Huang, Shoei-Sheng Lee, K-Lim King
  • Publication number: 20130316906
    Abstract: The invention relates to novel compounds of the formula (I) in which R1, R2, R3, R4, R5, Y, Q and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as herbicides and/or pesticides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the phenyl-substituted bicyclooctane-1,3-dione derivates and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as pesticides and/or for preventing unwanted plant growth.
    Type: Application
    Filed: October 28, 2011
    Publication date: November 28, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Alfred Angermann, Stefan Lehr, Guido Bojack, Reiner Fischer, Isolde Häuser-hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Hugh Rosinger, Arnd Voerste, Dieter Feucht
  • Publication number: 20130296373
    Abstract: The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.
    Type: Application
    Filed: May 6, 2013
    Publication date: November 7, 2013
    Applicant: Dow AgroSciences LLC
    Inventors: Kevin G. Meyer, W. John Owen, James M. Renga, Chenglin Yao, Benjamin M. Nugent, Jeremy Wilmot, Fangzheng Li, Karla Bravo-Altamirano
  • Publication number: 20130296375
    Abstract: The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides.
    Type: Application
    Filed: May 6, 2013
    Publication date: November 7, 2013
    Applicant: Dow AgroSciences LLC
    Inventors: Kevin G. Meyer, Karla Bravo-Altamirano, James M. Renga, Jessica Herrick, Benjamin M. Nugent, Timothy A. Boebel, Fangzheng Li, Nick X. Wang, W. John Owen, Paul R. Graupner, Chenglin Yao, Ronald J. Heemstra
  • Patent number: 8492562
    Abstract: Provided are a polymerizable compound shown below which is useful as a raw material for a polymer having less swelling in developing, a polymer obtained by polymerizing a raw material containing the above polymerizable compound, a photoresist composition which contains the above polymer and which is improved in LWR and an efficient production process for the polymerizable compound described above: wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or trifluoromethyl; R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like; W represents an alkylene group having 1 to 10 carbon atoms or the like; and Y1 and Y2 represent an oxygen atom or a sulfur atom.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: July 23, 2013
    Assignee: Kuraray Co., Ltd.
    Inventors: Junko Sato, Osamu Nakayama, Takashi Fukumoto
  • Patent number: 8431722
    Abstract: A cyclic alcohol of formula (II-1): wherein: R2, R3, and R4 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; or R2 and R3 or R3 and R4 combine to form an alkylene group comprising 3 to 6 carbon atoms; m is 1 or 2; R5, R6, R7, R8, R9, and R10 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; A is an oxygen atom; and B is an oxygen atom or a sulfur atom. In addition, a process for producing the cyclic alcohol of formula (II-1).
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: April 30, 2013
    Assignee: Kuraray Co., Ltd.
    Inventors: Osamu Nakayama, Takashi Fukumoto
  • Patent number: 8362169
    Abstract: Provided are 1) a polymer which is excellent in a reactivity to acid and a heat stability and which is less swollen in developing, 2) a compound shown below which is a raw material for the above polymer and 3) a photoresist composition which contains the above polymer and which is improved in LWR and excellent in a heat resistance. (wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or the like; R2 to R10 each represent independently a hydrogen atom, a linear alkyl group, a branched alkyl group or the like; and A and B each represent independently an oxygen atom or a sulfur atom).
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: January 29, 2013
    Assignee: Kuraray Co., Ltd.
    Inventors: Osamu Nakayama, Takashi Fukumoto
  • Publication number: 20120330033
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20120330032
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20120316349
    Abstract: A cyclic alcohol of formula (II-1): wherein: R2, R3, and R4 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; or R2 and R3 or R3 and R4 combine to form an alkylene group comprising 3 to 6 carbon atoms; m is 1 or 2; R5, R6, R7, R8, R9, and R10 are each independently a hydrogen atom, a linear alkyl group comprising 1 to 6 carbon atoms, a branched alkyl group comprising 3 to 6 carbon atoms, or a cyclic alkyl group comprising 3 to 6 carbon atoms; A is an oxygen atom; and B is an oxygen atom or a sulfur atom. In addition, a process for producing the cyclic alcohol of formula (II-1).
    Type: Application
    Filed: August 10, 2012
    Publication date: December 13, 2012
    Applicant: KURARAY CO., LTD.
    Inventors: Osamu NAKAYAMA, Takashi FUKUMOTO
  • Publication number: 20120208996
    Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.
    Type: Application
    Filed: February 9, 2012
    Publication date: August 16, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Jean-Louis PEGLION, Aimée DESSINGES
  • Patent number: 8188030
    Abstract: Disclosed herein is a fabric softener composition comprising a fabric softener active compound that comprises a quarternary ammonium salt and/or an imidazolinium salt, and a ketal adduct of formula (12) wherein R1 is C1-6 alkyl, R2 is hydrogen or C1-3 alkyl, each R3 and R4, is independently hydrogen or C1-6 alkyl, each R5 and R6 is independently hydrogen or C1-6 alkyl, or hydroxymethyl, R7 is hydrogen, C1-6 alkyl, C1-6 alkyl substituted with up to four OR8 groups wherein R8 is hydrogen, C1-6 alkyl, or acetyl, a is 0-3, and b is 0-1.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: May 29, 2012
    Assignee: Segetis, Inc.
    Inventors: Lee Richard Rieth, Dorie J. Yontz, Daniel Warren Gilbert
  • Patent number: 8178701
    Abstract: The present disclosure relates to the preparation of ketal compounds from glycerol and levulinic acid and esters, and uses thereof.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: May 15, 2012
    Assignee: Segetis, Inc.
    Inventor: Sergey Selifonov
  • Patent number: 8106221
    Abstract: The present invention is directed to aspartic protease inhibitors. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: January 31, 2012
    Assignee: Vitae Pharmaceuticals, Inc.
    Inventors: John J. Baldwin, Salvacion Cacatian, David A. Claremon, Lawrence W. Dillard, Patrick T. Flaherty, Alexey V. Ishchenko, Lanqi Jia, Gerard McGeehan, Robert D. Simpson, Suresh B. Singh, Colin M. Tice, Zhenrong Xu, Jing Yuan, Wei Zhao, Linghang Zhuang
  • Publication number: 20110118330
    Abstract: Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.
    Type: Application
    Filed: July 8, 2009
    Publication date: May 19, 2011
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Arun K. Ghosh
  • Patent number: 7906659
    Abstract: The present invention relates to certain carbocyclic and oxacarbocyclic fumaric acid oligomers and the use thereof for preparing a pharmaceutical preparation as well of pharmaceutical preparations containing these compounds.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: March 15, 2011
    Assignee: Biogen IDEC International GmbH
    Inventors: Rajendra Kumar Joshi, Hans-Peter Strebel
  • Publication number: 20110060112
    Abstract: Provided are 1) a polymer which is excellent in a reactivity to acid and a heat stability and which is less swollen in developing, 2) a compound shown below which is a raw material for the above polymer and 3) a photoresist composition which contains the above polymer and which is improved in LWR and excellent in a heat resistance. (wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or the like; R2 to R10 each represent independently a hydrogen atom, a linear alkyl group, a branched alkyl group or the like; and A and B each represent independently an oxygen atom or a sulfur atom).
    Type: Application
    Filed: February 20, 2009
    Publication date: March 10, 2011
    Applicant: KURARAY CO., LTD.
    Inventors: Osamu Nakayama, Takashi Fukumoto
  • Publication number: 20100331508
    Abstract: Provided are a polymerizable compound shown below which is useful as a raw material for a polymer having less swelling in developing, a polymer obtained by polymerizing a raw material containing the above polymerizable compound, a photoresist composition which contains the above polymer and which is improved in LWR and an efficient production process for the polymerizable compound described above: wherein n represents an integer of 0 to 2; R1 represents a hydrogen atom, methyl or trifluoromethyl; R2, R3, R4, R5, R6, R7, R8, R9 and R10 represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or the like; W represents an alkylene group having 1 to 10 carbon atoms or the like; and Y1 and Y2 represent an oxygen atom or a sulfur atom.
    Type: Application
    Filed: February 20, 2009
    Publication date: December 30, 2010
    Applicant: KURARAY CO., LTD.
    Inventors: Junko Sato, Osamu Nakayama, Takashi Fukumoto
  • Publication number: 20100316706
    Abstract: The present invention relates to certain carbocyclic and oxacarbocyclic fumaric acid oligomers and the use thereof for preparing a pharmaceutical preparation as well of pharmaceutical preparations containing these compounds.
    Type: Application
    Filed: August 23, 2010
    Publication date: December 16, 2010
    Inventors: Rajendra Kumar JOSHI, Hans-Peter Strebel
  • Patent number: 7825265
    Abstract: Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: November 2, 2010
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Roger Olsson, Lene Hyldtoft, Fabrice Piu, Magnus Gustafsson, Vladimir Sherbukhin, Birgitte Winther Lund
  • Patent number: 7781223
    Abstract: A fluorescent molecular wire is provided, having a fluorescent polymer main chain to which an optically active substituent is linked so as to be conjugatable form, the optically active substituent being represented by formula (I) below: where R1 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; R2, R3, R4, R5, R6, R7, R8, and R9 represent independently a hydrogen atom, a linear alkyl group having 1 to 30 carbon atoms that may have a substituent, a branched alkyl group having 2 to 30 carbon atoms that may have a substituent, a cyclic alkyl group having 3 to 30 carbon atoms that may have a substituent, an aryl group having 6 to 30 carbon atoms that may have a substituent, or an aralkyl group having 7 to 30 carbon atoms that may have a substituent, and R3 and R7 may be bonded respectively to R4 and R8 to form an alkylene group having 2 to 60 carbon atoms that may have a substituent; and R10 and R11 represent independently a hydrogen atom or an alkyl group having 1 to 15 carbon atoms t
    Type: Grant
    Filed: November 22, 2004
    Date of Patent: August 24, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Yoshito Tobe, Keiji Hirose
  • Patent number: 7696361
    Abstract: Biomimetic reagents capable of selectively forming non-covalent complexes and initiating intermolecular reactions with peptides in the gas phase are described. The reagents are particularly useful in gas phase peptides chemistry.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: April 13, 2010
    Assignee: California Institute of Technology
    Inventors: Jesse L. Beauchamp, Ryan R. Julian, Brian M. Stoltz, Jeremy A. May
  • Patent number: 7662977
    Abstract: The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: February 16, 2010
    Assignee: Semafore Pharmaceuticals, Inc.
    Inventors: Joseph R. Garlich, Donald L. Durden, Mary Patterson, Jingdong Su, Robert G. Suhr
  • Publication number: 20090203770
    Abstract: The present invention provides agents and compositions for modulating the apoptotic state of a cell. The agents comprise derivatives of antimycins which bind to an anti-apoptotic Bcl-2 family member protein. Further, the agents preferentially induce apoptosis in cells that over-express anti-apoptotic Bcl-2 family member proteins and typically exhibit reduced binding affinity for cytochrome B. Pharmaceutical uses of the agents and compositions include treating apoptosis-associated disease, such as neoplasia and drug resistance, are also disclosed.
    Type: Application
    Filed: June 25, 2007
    Publication date: August 13, 2009
    Applicant: Fred Hutchison Cancer Research Center
    Inventors: David M. Hockenberry, Julian A. Simon, Shie-Pon Tzung
  • Patent number: 7498451
    Abstract: The invention relates to a process for obtaining a pure aliphatic dialdehyde monoacetal by reaction of the corresponding aliphatic dialdehyde or a precursor of the corresponding aliphatic dialdehyde with one or more aliphatic mono- or polyhydric alcohols while distillatively removing water to obtain a reaction mixture which is separated distillatively, which comprises carrying out the distillative separation continuously in a dividing wall column to obtain pure aliphatic dialdehyde monoacetal as a sidestream from the dividing wall column, or in two distillation columns to obtain crude aliphatic dialdehyde monoacetal as a sidestream in the first distillation column, feed the crude aliphatic dialdehyde monoacetal to the second distillation column and obtain pure aliphatic dialdehyde monoacetal as the sidestream from the second distillation column.
    Type: Grant
    Filed: November 27, 2003
    Date of Patent: March 3, 2009
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Haderlein, Hans-Georg Göbbel, Wolfgang Siegel
  • Publication number: 20080015366
    Abstract: This invention describes protected 5,7-dihydroxy-4,4-dimethyl-3-oxoheptanoic acid ester and 5,7-dihydroxy-2-alkyl-4,4-dimethyl-3-oxoheptanoic acid ester for the synthesis of epothilones and epothilone derivatives and process for the production of these esters.
    Type: Application
    Filed: June 5, 2004
    Publication date: January 17, 2008
    Inventors: Juergen Westermann, Johannes Platzek, Orlin Petrov
  • Patent number: 7214538
    Abstract: The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of lithium ions. Additionally, the present invention provides a method of detecting lithium ions which comprises placing the novel optical sensor into communication with a biological fluid. Once the novel compound of the present invention encounters a lithium ion(s), a fluorescence is generated, the intensity of which is measured and allows for the determination of lithium ion concentration. The present invention provides a medical professional with the ability to selectively determine lithium ion concentration in a biological fluid thereby facilitating the treatment of various diseases, such as manic-depressive illness.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: May 8, 2007
    Assignees: Worcester Polytechnic Institute, Bayer Health Care, LLC.
    Inventors: John S. Benco, Hubert A. Nienaber, W. Grant McGimpsey
  • Patent number: 7169942
    Abstract: 1?-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having activity as either agonists or antagonists of the CB-1 and/or CB-2 receptors can be used for treating CB-1 or CB-2 mediated conditions.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: January 30, 2007
    Assignee: University of Tennessee Research Foundation
    Inventors: Bob M. Moore, II, Antonio M. Ferreira, Mathangi Krishnamurthy
  • Patent number: 7166226
    Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: January 23, 2007
    Assignee: Dionex Corporation
    Inventors: L. Andy Woodruff, Andrei V. Bordunov, Christopher A. Pohl
  • Patent number: 7022664
    Abstract: The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: April 4, 2006
    Assignee: Givaudan SA
    Inventor: Philip Kraft
  • Patent number: 6949537
    Abstract: The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.
    Type: Grant
    Filed: April 5, 2004
    Date of Patent: September 27, 2005
    Assignee: Semafore Pharmaceuticals, Inc.
    Inventors: Joseph R. Garlich, Donald L. Durden, Mary Patterson, Jingdong Su, Robert G. Suhr
  • Patent number: 6914109
    Abstract: The invention relates to a process for the preparation of 15-pentadecanolide by hydrogenating 15-pentadecenolide and to its use.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: July 5, 2005
    Assignee: Symrise GmbH & Co. KG
    Inventors: Walter Kuhn, Oskar Koch, Hans-Ulrich Funk, Gerhard Senft
  • Patent number: 6867295
    Abstract: One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: March 15, 2005
    Assignee: Dionex Corporation
    Inventors: L. Andy Woodruff, Andrei V. Bordunov, Christopher A. Pohl
  • Patent number: 6743564
    Abstract: Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: June 1, 2004
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Jun Hatakeyama, Tomohiro Kobayashi, Takeru Watanabe
  • Publication number: 20040092753
    Abstract: A method for producing unsaturated cyclic ethers of general formula (I) wherein Z represents (CHR4)q— or (CHR4)q—O—, q 0, 1, 2 or 3 and R1, R2, R3, R4 represent hydrogen or C1-C4-alkyl, by reacting dioles of general formula (II), wherein Z, R1, R2 and R3 have the above-mentioned meanings, in a liquid phase at temperatures of 150-300° C. in the presence of a support catalyst which is not activated prior to use by reduction and which contains cobalt and is doped with sulphur, containing cobalt, and an earth metal which is deposited by sol impregnation and is selected from the group containing platinum, palladium, rhodium, iridium, ruthenium, osmium, rhenium or mixtures thereof, on an inert support, characterized in that water is added.
    Type: Application
    Filed: September 3, 2003
    Publication date: May 13, 2004
    Inventors: Hagen Weigl, Klaus Ebel, Sylvia Huber, Andreas Kusche, Karsten Eller, Michael Hesse, Arthur Hohn
  • Patent number: 6590048
    Abstract: The present invention describes the use of cationic vinylidene, allenylidene and higher cumulenylidene complexes of ruthenium or osmium as catalysts or catalyst precursors for olefin metathesis reactions of all types, as well as to new cationic allenylidene complexes of ruthenium and osmium which can be used as metathesis catalysts with preferred embodiment. These catalysts or catalyst precursors are easy to prepare from well accessible, stable and essentially non toxic starting materials, can be isolated and stored, they exhibit a high catalytic activity, a good compatibility with functional groups, solvents, water and additives, and they need not to be activated by any additive.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: July 8, 2003
    Assignee: Studiengesellschaft Kohle mbH
    Inventors: Alois Fürstner, Pierre Dixneuf, Christian Bruneau, Michel Picquet
  • Publication number: 20030077656
    Abstract: A derivatized macrocyclic compound comprising the formula: 1
    Type: Application
    Filed: September 7, 2001
    Publication date: April 24, 2003
    Inventors: Andrei V. Bordunov, L. Andy Woodruff, Christopher A. Pohl
  • Patent number: 6544945
    Abstract: The present invention relates to cyclic pro-perfumes comprising a moiety derived from a fragrance raw material alcohol. Such cyclic perfumes may contain dioxolane and glucosyl orthesters that are suitable for use in delivering enhanced fragrance longevity to human skin.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: April 8, 2003
    Assignee: The Procter & Gamble Company
    Inventors: Gregory Scot Miracle, Kenneth Nathan Price, Lon Montgomery Gray
  • Publication number: 20030040633
    Abstract: A method for producing an amide derivative of the formula [XV] 1
    Type: Application
    Filed: September 13, 2002
    Publication date: February 27, 2003
    Inventors: Takashi Inaba, Yasuki Yamada
  • Patent number: 6482565
    Abstract: The present invention relates to a cross-linker for use in a photoresist which is suitable for a photolithography process using KrF (248 ru), ArF (193 nm), E-beam, ion beam or EUV light source. According to the present invention, preferred cross-linkers comprise a copolymer having repeating units derived from: (i) a compound represented by following Chemical Formula 1 and/or (ii) one or more compound(s) selected from the group consisting of acrylic acid, methacrylic acid and maleic anhydride.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: November 19, 2002
    Assignee: Hyundai Electronics Industries Co., Ltd.
    Inventors: Jae Chang Jung, Keun Kyu Kong, Myoung Soo Kim, Hyoung Gi Kim, Hyeong Soo Kim, Ki Ho Baik
  • Publication number: 20020137962
    Abstract: A ferulic acid derivative represented by the general formula: 1
    Type: Application
    Filed: May 23, 2002
    Publication date: September 26, 2002
    Applicant: Agency of Industrial Science and Technology
    Inventors: Takushi Sugino, Yo Shimizu, Hirosato Monobe
  • Publication number: 20020049337
    Abstract: A method for producing an amide derivative of the formula [XV] 1
    Type: Application
    Filed: October 26, 2001
    Publication date: April 25, 2002
    Inventors: Takashi Inaba, Yasuki Yamada