Nitrogen Bonded Directly To The Hetero Ring Patents (Class 549/371)
  • Publication number: 20140275134
    Abstract: The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
    Type: Application
    Filed: October 16, 2012
    Publication date: September 18, 2014
    Inventors: John P. Toscano, Daryl A. Guthrie
  • Publication number: 20130217899
    Abstract: The present invention relates to processes for the preparation of (2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (Fingolimod) and pharmaceutically acceptable salts thereof, and intermediates formed in such processes.
    Type: Application
    Filed: October 27, 2011
    Publication date: August 22, 2013
    Applicant: MAPI PHARMA LTD.
    Inventors: Ehud Marom, Michael Mizhiritskii, Shai Rubnov
  • Publication number: 20120108667
    Abstract: Disclosed herein are compounds, compositions, methods of treatment and synthetic methods for making compounds related to Ceramides and the use of Ceramides.
    Type: Application
    Filed: October 31, 2011
    Publication date: May 3, 2012
    Inventors: Zdzislaw M. Szulc, Alicja Bielawska, Yusuf A. Hannun
  • Publication number: 20100234417
    Abstract: A hetero-dimeric or hetero-oligomeric receptor, comprising at least one thyrotropin releasing hormone receptor subunit associated with at least one orexin receptor subunit.
    Type: Application
    Filed: November 9, 2007
    Publication date: September 16, 2010
    Applicant: DIMERIX BIOSCIENCE PTY LTD.
    Inventors: Kevin Donald George Pfleger, Ruth Marie Seeber, Heng See Boon, Karin Ann Eidne
  • Publication number: 20090137530
    Abstract: A novel amine compound represented by the following formula (I), which is superior in immunosuppressive action, rejection suppressive action and the like, and shows reduced side effects such as bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or hydrates thereof, or solvate, as well as a pharmaceutical composition containing this compound and a pharmaceutically acceptable carrier. wherein R is a hydrogen atom or P(?O)(OH)2, X is an oxygen atom or a sulfur atom, Y is CH2CH2 or CH?CH, R1 is cyano or alkyl having a carbon number of 1 to 4 and substituted by a halogen atom(s), R2 is alkyl having a carbon number of 1 to 4 and optionally substituted by a hydroxyl group(s) or a halogen atom(s), R3 and R4 may be the same or different and each is a hydrogen atom or alkyl having a carbon number of 1 to 4, and n is 5-8.
    Type: Application
    Filed: December 15, 2006
    Publication date: May 28, 2009
    Applicant: Mitsubishi Tanabe Pharma Corporation
    Inventors: Masatoshi Kiuchi, Kaoru Marukawa, Nobutaka Kobayashi, Kunio Sugahara
  • Patent number: 6951882
    Abstract: Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: October 4, 2005
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nicholas I Carruthers, Todd K. Jones, Xiaobing Li, Timothy W. Lovenberg, Laura C. McAtee, Victor K. Phuong, Dale A. Rudolph, Steven W. Sutton
  • Patent number: 6723866
    Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, A1, A2, Z1, Z2, a, b, L1, L2 and L3 are as defined in claim 1, and to liquid-crystalline media comprising at least compound of the formula I and to electro-optical displays containing a liquid-crystalline medium of this type.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: April 20, 2004
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Peer Kirsch, Michael Heckmeier, Joachim Krause, Marc Lenges, Gerald Unger
  • Patent number: 6716491
    Abstract: A liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, which comprises one or more compounds of the formula I where R1, A1, A2, Z1, Z2, L1, L2 and n are as defined herein, is suitable for use in, for example, MLC, TN and STN displays.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: April 6, 2004
    Assignee: Merck Patent GmbH
    Inventors: Kazuaki Tarumi, Brigitte Schuler, Matthias Bremer, Ulrich Finkenzeller, Eike Poetsch, Heike Kniel
  • Patent number: 6472414
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) —O—; or (3) B is: and wherein L2, L1, R1, R2, R3, R3′, R3a, R3b, R4, R4′, R5, X,  are as defined herein.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: October 29, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
  • Publication number: 20020091242
    Abstract: Novel acid-sensitive compounds comprising a cyclic ortho-ester that is acid-sensitive, and their salts, and comprising at least one hydrophilic substituent. These compounds are useful, for example, for forming conjugates (liposomes, complexes, nanoparticles and the like) with biologically active substances and releasing them into cellular tissues or compartments whose pH is acidic, or as nonionic surfactant for stabilizing particles encapsulating a biologically active substance and then destabilizing them in acid medium, or alternatively as a vector covalently linked to a therapeutic molecule so as to release said therapeutic molecule into the cellular tissues or compartments whose pH is acidic.
    Type: Application
    Filed: October 10, 2001
    Publication date: July 11, 2002
    Inventors: Michel Bessodes, Christophe Masson, Daniel Scherman, Barbara Wetzer
  • Publication number: 20020015804
    Abstract: There can be provided a liquid crystalline compound expressed by the general formula (1): 1
    Type: Application
    Filed: July 22, 1999
    Publication date: February 7, 2002
    Inventors: YASUHIRO HASEBA, SHUICHI MATSUI, KAZUTOSHI MIYAZAWA, NORIHISA HACHIYA, ETSUO NAKAGAWA
  • Patent number: 6200932
    Abstract: The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) in which A, B, G, X, Y, Z and n are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: March 13, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Udo Schneider, Peter Dahmen, Markus Dollinger, Christoph Erdelen, Ulrike Wachendorff-Neumann
  • Patent number: 5840964
    Abstract: A process for the preparation of 2-(2-fluoro-4-biphenyl)propianic acid enantiomers comprising a II order resolution of ketals of formula ##STR1## wherein R.sub.1 ad R.sub.2 have the meanings reported in the description; the asterisk shows the chiral carbon atom and the asymmetric carbon atoms marked by .alpha. and .beta. have both R or S configuration is described.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: November 24, 1998
    Assignee: Zambon Group S.P.A.
    Inventors: Claudio Pozzoli, Graziano Castaldi
  • Patent number: 5770773
    Abstract: A process for the preparation of 5-amino-1,3-dioxanes of formula (I), comprising the catalytic hydrogenation of the new oximes of formula (II) is described.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: June 23, 1998
    Assignee: Zambon Group S.p.A.
    Inventors: Antonio Nardi, Marco Villa
  • Patent number: 5760246
    Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2;R.sup.x is H, alkyl, aryl or halogen;A is(1) a bond;(2) --O--; or(3) ##STR2## B is: ##STR3## and wherein L.sup.2, L.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.3', R.sup.3a, R.sup.3b, R.sup.4, R.sup.4', R.sup.5, X, ##STR4## are as defined herein.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: June 2, 1998
    Inventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
  • Patent number: 5691372
    Abstract: The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: November 25, 1997
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Roger D. Tung, Govinda Rao Bhisetti
  • Patent number: 5663372
    Abstract: Described herein is a process for the preparation of 5-amino-1,3-dioxanes of formula (I), wherein R and R.sub.1 have the meanings reported in the description, comprising the catalytic hydrogenation of the new oximes of formula (II).
    Type: Grant
    Filed: October 10, 1996
    Date of Patent: September 2, 1997
    Assignee: Zambon Group S.p.A.
    Inventors: Antonio Nardi, Marco Villa
  • Patent number: 5580993
    Abstract: A process for the preparation of Iopamidol and 5-amino-2,2-dialkyl-1,3-dioxanes of formula ##STR1## wherein R and R.sub.1 are the same or different and represent a straight or branched C.sub.1 and C.sub.2 alkyl group or together with the carbon atom to which they are bonded, form a C.sub.5 -C.sub.6 cycloaliphatic ring; comprising the transformation of a 2,2-dialkyl-1,3-dioxane-5-carboxylic acid ester of formula ##STR2## wherein R.sub.2 represents a straight or branched C.sub.1 -C.sub.2 alkyl group, a phenyl optionally substituted by nitro groups or a benzyl; by treatment with ammonia into the corresponding amides and the subsequent rearrangement of the latter into the compounds of formula I, by treatment with a hypohalogenite. The resultant ketals may be used as is, or be converted to 2-amino-1,3-propanediol, and reacted with 5-amino-2,4,6-triiodo-isophthalic acid dichloride or, alternatively,L-5-(2-acetoxy-propionylamino)-2,4,6-triido-isophthalic acid dichloride, to produce Iopamidol.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: December 3, 1996
    Assignee: Zambon Group S.p.A.
    Inventors: Marco Villa, Antonio Nardi
  • Patent number: 5488166
    Abstract: Provided by the present invention is a process for the biocatalytic synthesis of optically pure sphingosines from achiral starting material. The stereoisomers of sphingosine are prepared from chiral arene diols using stereospecific reaction techniques to obtain the desired sphingosine or derivative thereof.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: January 30, 1996
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventor: Tomas Hudlicky
  • Patent number: 5376683
    Abstract: The invention relates to .DELTA..sup.8 - and .DELTA..sup.9 -prostaglandin derivatives of formula I, ##STR1## in which means the radicals or , R.sup.1 means ##STR2## COOR.sup.4 or CONHR.sup.5, R.sup.2 and R.sup.3 respectively mean a hydrogen atom or a hydroxy group, and the OH group can be respectively in alpha- or beta- position,means a CH.sub.2 group, an O or S atom,W means hydrogen, --OR.sup.6, halogen, --CN--, --NO.sub.2, trifluoromethyl or COOR.sup.6, and if R.sup.4 means hydrogen, their salts with physiologically compatible bases, the alpha-, beta- or gamma- cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and their pharmaceutical use.
    Type: Grant
    Filed: November 25, 1992
    Date of Patent: December 27, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Hartmut Rehwinkel, Helmut Vorbruggen, Karl H. Thierauch, Claus S. Sturzebecher
  • Patent number: 5360818
    Abstract: The present invention provides compounds having the formula ##STR1## wherein R.sub.1 is alkyl, alkenyl and alkynyl having from 2 to about 20 carbon atoms; R.sub.2, R.sub.3 and R.sub.6 are independently H, phenyl or alkyl having from 1 to about 20 carbon atoms; and R.sub.4 and R.sub.5 are independently H, R.sub.6 imino, or amidino, and pharmaceutically acceptable salts thereof which are useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
    Type: Grant
    Filed: August 24, 1993
    Date of Patent: November 1, 1994
    Assignee: Sphinx Pharmaceuticals Corporation
    Inventors: Jack B. Jiang, Mary G. Johnson, Jeffrey Nichols
  • Patent number: 5208351
    Abstract: The present invention provides a process for the preparation of N-cyanoimidocarbonates of the general formula: ##STR1## in which R.sup.1 and R.sup.2 are the same and are alkyl radicals containing up to 4 carbon atoms or R.sup.1 and R.sup.2 are joined together to give an ethylene or propylene chain which is optionally substituted by an alkyl radical containing up to 3 carbon atoms, wherein an imidocarbonate obtained in aqueous alkaline solution from the appropriate alcohol and cyanogen chloride is added with an acid to an aqueous solution of cyanamide in such a manner that the reaction mixture has a pH value of from 3 to 8.
    Type: Grant
    Filed: July 15, 1992
    Date of Patent: May 4, 1993
    Assignee: SKW Trostberg Aktiengesellschaft
    Inventors: Franz Thalhammer, Stefan Weiss
  • Patent number: 5100577
    Abstract: A ferroelectric liquid crystalline mixture containing at least one optically active compound of the general formula ##STR1## wherein X.sup.1 denotes a single covalent bond, --COO--, --OOC--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 -- or --CH.sub.2 O--; one of rings A.sup.1, A.sup.2 and A.sup.3 represents trans-m-dioxan-2,5-diyl and the other two of rings A.sup.1, A.sup.2 and A.sup.3 each independently represent unsubstituted 1,4-phenylene or 1,4-phenylene substituted with cyano, halogen or lower alkyl; R.sup.1 and R.sup.2 each independently signify an optionally halogen-substituted alkyl group with up to 18 carbon atoms in which optionally 1 CH.sub.2 group or 2 non-adjacent CH.sub.2 groups is/are replaced by --O--, --CO--, --COO-- and/or --OOC--,as well as novel compounds falling under formula I and ferroelectric electrode-optical indicating devices including same.
    Type: Grant
    Filed: January 11, 1990
    Date of Patent: March 31, 1992
    Assignee: Hoffman-La Roche Inc.
    Inventors: Richard Buchecker, Hans-Jurgen Fromm, Stephen Kelly, Martin Schadt, Alois Villiger
  • Patent number: 4996316
    Abstract: A process for the preparation of tertiary N,N-dimethylamines by the reaction of primary amines, formaldehyde, and hydrogen under pressure and at elevated temperature in the presence of a nickel-containing hydrogenation catalyst in the liquid phase. The hydrogenation catalyst is suspended in a solvent, the nickel concentration is 0.1 to 10% by weight, based on the primary amine. The starting materials are separate from each other, brought to 80.degree. to 150.degree. C. and 1 to 15 MPa and fed into the catalyst suspension simultaneously with stirring and reacted in one step to form the tertiary N,N-dimethylamines.
    Type: Grant
    Filed: December 24, 1988
    Date of Patent: February 26, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Jurgen Weber, Detlef Kampmann, Claus Kniep
  • Patent number: 4988827
    Abstract: Ether-substituted isonitriles, Tc99m complexes thereof, and processes for myocardial tissue radioimaging using the Tc99m complexes.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: January 29, 1991
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Paul L. Bergstein, Vinayakam Subramanyam
  • Patent number: 4983739
    Abstract: Optically active compounds of the formula I ##STR1## in which R.sup.1 is C.sub.1 -C.sub.4 -alkyl, phenyl or benzyl, R.sup.2 is a radical of the formula II or IIa ##STR2## in which R.sup.3 is H or --CH.sub.3, or R.sup.1 and R.sup.2 together form a radical of the formula ##STR3## in which R.sup.2 has the meaning given above; and * represents predominantly R or predominantly S configuration.The compounds can be polymerized to give homopolymers or copolymers. The compounds and the polymers can be complexed with iridium(I) salts in the presence of a diene. The complexes are suitable as enantioselective catalysts.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: January 8, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Jurgen Kaschig
  • Patent number: 4978793
    Abstract: A process of forming 2-amino-1,3-propanediol by reducing the compound, 5-nitro-1,3-dioxane and subsequently hydrolyzing the reduced compound.
    Type: Grant
    Filed: June 23, 1988
    Date of Patent: December 18, 1990
    Assignee: W. R. Grace & Co.-Conn.
    Inventors: Jennifer M. Quirk, Stephen G. Harsy, Christer L. Hakansson
  • Patent number: 4927946
    Abstract: Unpurified 2-bromo-2-nitro-1,3-propanediol is used as the starting material for a process for the preparation of 5-bromo-5-nitro-1,3-dioxane from 2-nitro-1,3-propanediol without the use of an organic solvent on an industrial scale. This is carried out in such a way that in a first stage a mixture of bromine and aqueous hydrogen bromide solution is cooled and an aqueous solution of an alkali metal or an alkaline-earth metal salt of 2-nitro-1,3-propanediol is added at such a rate that, with cooling, the maximum reaction temperature does not exceed 30.degree. C., and then in a second reaction stage paraformaldehyde and sulfuric acid are added, left to react above room temperature, and the organic phase separated.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: May 22, 1990
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Willi Wuest, Rainer Eskuchen, Herbert Esser, Hasso Leischner
  • Patent number: 4826620
    Abstract: The new esters derived from a chiral compound containing two OH groups and at least one mesogenic carboxylic acid which have the general formula (I) ##STR1## in which X.sup.1 =O--H or O--CO--(C.sub.1 to C.sub.12)alkyl and X.sup.2 =O--MC or X.sup.1 and X.sup.2 denote O-MC independently of each other, where MC is the molecular radical of a mesogenic monocarboxylic acid after splitting off an OH group.The esters or esters substituted in the aromatic part of the phenolic part preferably find application as an admixture intwistable liquid crystal phases in which they produce a temperature compensation and a high degree of twisting.
    Type: Grant
    Filed: January 21, 1988
    Date of Patent: May 2, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerd Heppke, Detlef Lotzsch, Feodor Oestreicher, Gunter Scherowsky
  • Patent number: 4725682
    Abstract: Sulfur-containing bis-amino carbamate compounds exhibit outstanding acaricidal, nematocidal and insecticidal activity.
    Type: Grant
    Filed: December 2, 1986
    Date of Patent: February 16, 1988
    Assignee: Rhone-Poulenc Nederland, B.V.
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4704227
    Abstract: Compounds of the formula IR.sup.1 --A.sup.1 --Z.sup.1 --A.sup.2 --R.sup.2 IwhereinR.sup.1 and R.sup.2 are each H, an alkyl, alkoxy, alkanoyl, alkanoyloxy or alkoxycarbonyl group with in each case 1-10 C atoms, F, Cl, Br, CN or R.sup.3 --A.sup.3 --Z.sup.2 --,A.sup.1 is --A--, --A.sup.4 --A--or --A--A.sup.4 --,A is a 1,3-dioxane-2,5-diyl or a 1,3-dithiane-2,5-diyl group,A.sup.2, A.sup.3 are each a 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl,and A.sup.4 1,3-dithiane-2,5-diyl, piperidine-1,4-diyl or 1,4-bicyclo(2,2,2)octylene group, or a 1,4-phenylene, pyrimidine-2,5-diyl or pyridazine-3,6-diyl group which is unsubstituted or substituted by one or two F and/or Cl atoms and/or CH.sub.3 groups and/or CN groups,Z.sup.1 and Z.sup.2 are each --CO--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O or a single bond andR.sup.3 is H, an alkyl, alkoxy, alkanoyl, alkanoyloxy or alkoxycarbonyl group with in each case 1-10 C atoms, F, Cl, Br or CN, with the proviso that(a) at least one group A.sup.2, A.sup.
    Type: Grant
    Filed: February 15, 1985
    Date of Patent: November 3, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Joachim Krause, Andreas Wachtler, Reinhard Hittich, Georg Weber, Bernhard Scheuble
  • Patent number: 4676924
    Abstract: New compounds of the general formula: ##STR1## wherein the symbols X stand for carbon atom bonded with two hydrogen atoms /--CH.sub.2 -- group/ and the symbols Z stand for oxygen atom or the symbols X stand for oxygen atom and the symbols Z stand for carbon atom bonded with two hydrogen atoms /--CH.sub.2 -- group/, m is an integer of 1 to 2, R represents an alkyl /H.sub.2n+1 C.sub.n / or an 4-alkylphenyl /H.sub.2n+1 C.sub.n --C.sub.6 H.sub.4 / or an alkylbiphenyl /H.sub.2n+1 C.sub.n --C.sub.6 H.sub.4 --C.sub.6 H.sub.4 / or an alkylcyclohexylphenyl group /H.sub.2n+1 C.sub.n --C.sub.6 H.sub.10 --C.sub.6 H.sub.4 /, the term alkyl group signifies an alkyl chain containing 1 to 15 carbon atoms or it also signifies a branched-chain alkyl group C.sub.2 H.sub.5 --CH/CH.sub.3 /--/CH.sub.2 /.sub.k where k in an integer of 1 to 3, have utility as liquid crystals. A process for manufacture of compounds of the general formula I.
    Type: Grant
    Filed: June 28, 1985
    Date of Patent: June 30, 1987
    Assignee: Wojskowa Akademia Techniczna
    Inventors: Roman Dabrowski, Jerzy Dziaduszek, Jaroslaw Szulc, Zygfryd Witkiewicz, Zofia Stolarz, Krystyna Kenig, Gabriela Adamska
  • Patent number: 4567302
    Abstract: Quaternary ammonium salts exhibiting strong antimicrobial activity are disclosed along with the method of using them as antimicrobial agents. The salts having the formulas I or II: ##STR1## wherein R is C.sub.1-20 alkyl, C.sub.5-7 cycloalkyl or an aralkyl group, R.sup.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: January 28, 1986
    Inventor: Kallidaikurichi N. Sivaramakrishnan
  • Patent number: 4561876
    Abstract: Herbicide antidote compounds having the formula: ##STR1## in which R is haloalkyl wherein halo is chlorine, bromine or iodine and the alkyl group has 1-4 carbon atoms, inclusive;R.sub.1 is selected from the group consisting of hydrogen; lower alkyl having 1-4 carbon atoms, inclusive; alkenyl having 2-4 carbon atoms, inclusive; and phenyl;R.sub.2 is selected from the group consisting of hydrogen and lower alkyl having 1-4 carbon atoms, inclusive;R.sub.3 is selected from the group consisting of hydrogen and lower alkyl having 1-4 carbon atoms, inclusive;R.sub.4 is selected from the group consisting of hydrogen and a nitro group; andeither R.sub.3 is hydrogen or R.sub.4 is hydrogen.
    Type: Grant
    Filed: June 16, 1981
    Date of Patent: December 31, 1985
    Assignee: Stauffer Chemical Co.
    Inventor: Francis H. Walker
  • Patent number: 4551472
    Abstract: Unsymmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity.
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: November 5, 1985
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4551264
    Abstract: New polyhalogenoaromatic compounds of Formula I ##STR1## wherein Y and Z are each independently alkyl, alkoxy or alkanoyl each of 1 to 12 C atoms, --COOR.sup.1, --O--CO--R.sup.1, CN, NO.sub.2, NH.sub.2 or OH;Q is one or two identical or different radicals selected from Ph, Cy, 1,4-bicyclo[2,2,2]octylene or 1,3-dioxane-2,5-diyl;X.sup.1 to X.sup.4 are each independently H, F, Cl or Br;R.sup.1 is alkyl of 1 to 4 C atoms, Ph--R.sup.2 or Cy--R.sup.2 ;R.sup.2 is alkyl or alkoxy each of 1-12 C atoms or CN;Ph is 1,4-phenylene; and Cy is 1,4-cyclohexylene,can be used as components of liquid-crystal dielectrics.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: November 5, 1985
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rudolf Eidenschink, Michael Romer, Georg Weber
  • Patent number: 4396414
    Abstract: A method of increasing the yield of legumes (soybeans) utilizing a compound of the formula ##STR1## where R is chloromethyl or dichloromethyl; R.sup.1 is lower alkyl, vinyl or phenyl; R.sup.2 is hydrogen or lower alkyl and R.sup.3 is hydrogen or lower alkyl.
    Type: Grant
    Filed: June 25, 1981
    Date of Patent: August 2, 1983
    Assignee: Stauffer Chemical Company
    Inventor: Lawrence L. Buren
  • Patent number: 4338450
    Abstract: Carbamate-sulfenyl-carba moyl fluoride compounds are valuable insecticidal compositions and are also useful intermediates in the production of bis-carbamate compounds.
    Type: Grant
    Filed: December 1, 1975
    Date of Patent: July 6, 1982
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4335138
    Abstract: Novel carbamates derived from substituted cyclic .beta.-keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.
    Type: Grant
    Filed: September 15, 1980
    Date of Patent: June 15, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Walter-Wielant Wiersdorff, Karl-Heinz Geiss, Harald Weifenbach, Wolfgang Worstmann, Dieter Lenke, Rolf Kretzschmar
  • Patent number: 4329293
    Abstract: An improved process is disclosed for sulfenylating carbamates in the presence of a solvent and acid acceptor, in which the reaction between a carbamate and a sulfenyl halide is conducted in the presence of a catalytic amount of a complex of a lower alkylamine and sulfur dioxide. Several methods for preparing and utilizing the complex in the reaction are disclosed and exemplified.
    Type: Grant
    Filed: October 31, 1980
    Date of Patent: May 11, 1982
    Assignee: FMC Corporation
    Inventors: John W. Ager, Maurice J. C. Harding, Charles E. Hatch, III