Plural Chalcogens Bonded Directly To The Hetero Ring Patents (Class 549/400)
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Patent number: 5760074Abstract: The invention relates to certain cis and trans benzopyrans having substituted benzamides at position C-4 and to their use in treating and/or preventing certain CNS disorders.Type: GrantFiled: June 2, 1995Date of Patent: June 2, 1998Assignee: SmithKline Beecham p.l.c.Inventors: Wai Ngor Chan, Helen Kate Ann Morgan, Mervyn Thompson, John Morris Evans
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Patent number: 5756538Abstract: Certain flavonoids, notably derivatives of flavone, chrysin and apigenin, together with dimers thereof such as amentoflavone, have been found to possess anxiolytic properties (i.e., anxiety reducing properties) without exhibiting a sedative effect. Novel compounds and pharmaceutical formulations are also described.Type: GrantFiled: May 31, 1996Date of Patent: May 26, 1998Assignee: University of StrathclydeInventors: Bruce Kennedy Cassels, Federico Jose Dajas, Jorge Horacio Medina, Alejandro Constantino Paladini, Rodolfo Horacio Silveira
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Patent number: 5702691Abstract: The present invention relates to flavanonol derivatives represented by formula (1): ##STR1## (wherein R.sup.1 represents an alkyl group, and each of R.sup.2 and R.sup.3 represents a hydrogen atom, an alkyl group which may have a substituent, an alkoxyl group which may have a substituent, a hydroxyl group, a cyano group, or a halogen atom), as well as to hair-nourishing and hair-growing compositions containing the derivatives. The compounds accelerate differentiation and proliferation of hair matrix cells, thereby exhibiting remarkable hair-nourishing and hair-growing effects.Type: GrantFiled: September 16, 1996Date of Patent: December 30, 1997Assignee: Kao CorporationInventors: Susumu Ichinose, Yoshinori Nishizawa, Atsushi Ohuchi, Hideshi Kidena, Mitsuyuki Hotta
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Patent number: 5675023Abstract: The present invention relates to a chromone derivative and an aldose reductase inhibitor comprising said compound as efective component, which is represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, etc., R.sub.3 represents an oxygen atom, a sulfur atom, etc., R.sub.7 represents a phenyl group substituted or not substituted, etc., and R represents a hydrogen atom or a lower alkoxy group. The present compounds exhibit superior inhititory action on aldose reductase and are useful for the treatment of various complications of diseases in diabetes, such as cataract, retinopathy, keratopathy, nephropathy, and neuropathy.Type: GrantFiled: June 6, 1995Date of Patent: October 7, 1997Assignee: Tsumura & Co.Inventors: Yasushi Igarashi, Takuji Yamaguchi, Yoshimitsu Ogawa, Mika Tomita, Hiroko Hayashi, Toshitsugu Sato, Kunio Hosaka
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Patent number: 5637709Abstract: Polychromatic compounds of pyrans having a substituted adamantane or a polycyclic ring system, with the exception of adamantane, in the 2-position of the pyran ring, having the structure ##STR1## whereby the residues R.sub.1 -R.sub.4 are independently substituents selected from the series H, alkyl, substituted phenyl, phenyl, naphthyl, OH, alkoxy (C.sub.1 -C.sub.4), halogen, alkylamino, dialkylamino, cyan, trifluormethyl, or, R.sub.1 and R.sub.2 or R.sub.3 and R.sub.4 or R.sub.2 and R.sub.3 are constituents of at least one condensed aromatic, heteroaromatic or an alkane ring, wherein said heteroaromatic ring is selected from the group consisting of pyridine, pyrimidine, pyridazine, quinoline, isoquinoline, naphthyridine, quinazoline, quinoxaline, phthalazine, pteridine, phenazine, and benzoquinoline which are substituted by the same residues as R.sub.1 -R.sub.Type: GrantFiled: February 9, 1995Date of Patent: June 10, 1997Assignee: Optische Werke G. RodenstockInventor: Manfred Melzig
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Patent number: 5629424Abstract: Process for enriching the concentration of an enantiomer (or a diastereomer) in a mixture of optically active isomers. The process includes preparing a solution containing the mixture of the optically active isomers and a chiral collector in which the chiral collector and the enantiomer (or diastereomer) are associated with each other. A gas is bubbled through a pool of the solution to form a foam, the surfaces of the bubbles in the foam having the chiral collector and the enantiomer (or diastereomer) preferentially adsorbed thereto so that the concentration ratio of the optically active isomers at said bubble surfaces differs from that in the bulk of the pool. The foam is moved vertically through a column above the pool such that during said movement at least a portion of the bubbles comprising the foam break thereby allowing liquid to drain toward the pool to provide an internal reflux within the column.Type: GrantFiled: November 29, 1995Date of Patent: May 13, 1997Assignee: The Curators of the University of MissouriInventors: Daniel W. Armstrong, Yubing Tang
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Patent number: 5616719Abstract: Photoactive indicator compounds of the formula ##STR1##Type: GrantFiled: May 9, 1995Date of Patent: April 1, 1997Assignee: Behringwerke AGInventors: Dariush Davalian, Rajendra Singh, Edwin F. Ullman
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Patent number: 5596100Abstract: A method is provided for the regioselective, palladium catalyzed carbo- or heteroannulation of internal alkynes by aryl iodides containing o-substituted side chains to yield aromatic carbocyclic and heterocyclic ring systems.Type: GrantFiled: April 4, 1995Date of Patent: January 21, 1997Assignee: Iowa State University Research Foundation, Inc.Inventor: Richard C. Larock
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Patent number: 5571844Abstract: The invention relates to amidinophenylalanine derivatives, to the synthesis of these compounds, to their use and to pharmaceutical compositions which contain these compounds which act as thrombin inhibitors.Type: GrantFiled: December 8, 1994Date of Patent: November 5, 1996Assignee: Behringwerke AktiengesellschaftInventors: Werner St uber, Rainer Koschinsky
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Patent number: 5552551Abstract: Proton-transfer, low self-absorbing chromophores of the formula: ##STR1## wherein R.sub.2 and R.sub.3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo or an ether group, R.sub.4 is O or N--H, and R.sub.5 is thienyl, naphthyl, furanyl, pyrrolyl, phenyl vinyl, diphenyl vinyl, phenyl ethynyl, hydroxy chromonyl phenyl, didecyloxy hydroxy chromonyl phenyl, phenyl or ##STR2## wherein R.sub.1 is vinyl, vinyl phenyl, vinyl benzyl, alkyl ethenyl, or alkyl phenyl ethenyl, provided that when R.sub.5 is phenyl and R.sub.2 and R.sub.3 are hydrogen, R.sub.4 is N--H.Type: GrantFiled: July 26, 1995Date of Patent: September 3, 1996Assignee: Florida State UniversityInventors: Joseph B. Schlenoff, Kurtis F. Johnson, Jayesh Dharia, Feng Gao
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Patent number: 5550152Abstract: The invention relates to benzopyran leukotriene B.sub.4 (LTB.sub.4) antagonists and pharmaceutical compositions containing the compounds. The compounds inhibit the action of LTB.sub.4 and are therefore useful in the treatment of LTB.sub.4 induced illnesses such as inflammatory disorders.Type: GrantFiled: September 30, 1994Date of Patent: August 27, 1996Assignee: Pfizer Inc.Inventors: Kevin Koch, Lawrence S. Melvin, Jr., Lawrence A. Reiter, Sally G. Ruggeri
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Patent number: 5521216Abstract: The present invention relates to a chromone derivative of formula (1): ##STR1## (wherein R.sub.1 and R.sub.2 are the same or different and independently represent a hydrogen atom or a lower alkyl group) as well as a synthetic intermediate thereof and an aldose reductase inhibitor comprising said derivative as an active ingredient. The chromone derivatives of the present invention can be easily synthesized, and are useful as aldose reductase inhibitor with an excellent inhibitory action on aldose reductase.Type: GrantFiled: May 12, 1994Date of Patent: May 28, 1996Assignee: Tsumura & Co.Inventors: Yasushi Igarashi, Takuji Yamaguchi, Kunio Hosaka
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Patent number: 5510373Abstract: This invention relates to certain hydroxy derivatives of 3,4-dihydro-2,5,7,8-tetraalkyl-2H-1-benzopyran-2-carboxylic acids and the lactones thereof, to the processes and intermediates useful for their preparation and to their use as free radical scavengers useful in the treatment of tissue damage implicated with free oxygen radicals.Type: GrantFiled: October 5, 1994Date of Patent: April 23, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: J. Martin Grisar, Margaret A. Petty, Frank Bolkenius
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Patent number: 5455267Abstract: The present invention relates to a chromone derivative and an aldose reductase inhibitor comprising said compound as efective component, which is represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, etc., R.sub.3 represents an oxygen atom, a sulfur atom, etc., R.sub.7 represents a phenyl group substituted or not substituted, etc., and R represents a hydrogen atom or a lower alkoxy group. The present compounds exhibit superior inhititory action on aldose reductase and are useful for the treatment of various complications of diseases in diabetes, such as cataract, retinopathy, keratopathy, nephropathy, and neuropathy.Type: GrantFiled: October 12, 1994Date of Patent: October 3, 1995Assignee: Tsumura & Co.Inventors: Yasushi Igarashi, Takuji Yamaguchi, Yoshimitsu Ogawa, Mika Tomita, Hiroko Hayashi, Toshitsugu Sato, Kunio Hosaka
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Patent number: 5416118Abstract: Novel bicyclic amides of the formula ##STR1## wherein Ar.sup.1 and Ar.sup.2 are phenyl, R.sup.2 -substituted phenyl, heteroaryl or R.sup.2 -substituted heteroaryl, wherein R.sup.2 is 1 to 3 substituents independently selected from the group consisting of halogeno, hydroxy, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino and lower dialkylamino;X, Y and Z are --CH.sub.2 --, --CH(alkyl)--, --C(alkyl).sub.2 --, --NH--, --N(alkyl)--, --O-- or --SO.sub.r, wherein r is 0, 1 or 2, and m, n and p are 0 or 1;R.sup.1 is an alkyl chain of 1 to 25 carbon atoms; an alkyl chain substituted by one or more optionally substituted phenyl or heteroaryl groups; an alkyl chain --O--, --SO.sub.r, phenylene, R.sup.2 -substituted phenylene, heteroarylene or R.sup.Type: GrantFiled: September 28, 1993Date of Patent: May 16, 1995Assignee: Schering CorporationInventors: John W. Clader, Thomas Fevig, Wayne Vaccaro, Joel G. Berger
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Patent number: 5403842Abstract: The invention relates to benzopyranone and benzothiopyranone compounds, compositions and methods of use which have adrenergic and serotonergic activity.Type: GrantFiled: May 26, 1992Date of Patent: April 4, 1995Assignee: Recordati S.A., Chemical and Pharmaceutical CompanyInventors: Amedeo Leonardi, Gianni Motta, Carlo Riva, Rodolfo Testa
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Patent number: 5360915Abstract: A modified alkali metal or ammonium huminate being made from molecules of the group consisting of ##STR1## wherein R.sub.1, R.sub.3 and R.sub.4 are individually hydrogen or --OH, R.sub.2 is ##STR2## or --CH.sub.2 -- and R.sub.5 and R.sub.6 are individually selected from the group consisting of hydrogen, --OH and --OCH.sub.3, with the proviso that R.sub.4, R.sub.5 and R.sub.6 are not all hydrogen at the same time and their preparation and their medical uses.Type: GrantFiled: October 14, 1992Date of Patent: November 1, 1994Assignee: Rutgerswerke Aktiengesellschaft AGInventors: Urs N. Riede, Bernhard Seubert
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Patent number: 5359098Abstract: Sigma binding site agents having the formula ##STR1## wherein A.sup.1, A.sup.2, A.sup.3, B, y and 2 are defined in the specification, W is halogen, which are novel intermediates useful in preparing the presently binding site agents.Type: GrantFiled: November 15, 1993Date of Patent: October 25, 1994Assignee: Guilford Pharmaceuticals Inc.Inventors: Ronald H. Erickson, Kenneth J. Natalie, Jr., Michael J. Pontecorvo, Waclaw J. Rzeszotarski
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Patent number: 5278174Abstract: Sigma binding site agents having the formula ##STR1## which are useful to inhibit sigma binding site-induced activity, pharmaceutical compositions including these agents, and methods of using these agents to inhibit sigma binding site-induced activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented agents.Type: GrantFiled: May 17, 1991Date of Patent: January 11, 1994Assignee: Scios Nova, Inc.Inventors: Ronald H. Erickson, Kenneth J. Natalie, Jr., Michael J. Pontecorvo, Waclaw J. Rzeszotarski
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Patent number: 5276054Abstract: Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##Type: GrantFiled: October 16, 1992Date of Patent: January 4, 1994Assignee: Merck & Co., Inc.Inventors: Maria T. Diez, Michael A. Goetz, Robert A. Giacobbe, Otto D. Hensens, Leeyan Huang, Isabel Martin, E. Tracy T. Jones, Siobhan Stevens-Miles, Yu L. Kong
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Patent number: 5232944Abstract: Novel chroman derivatives of the formula I ##STR1## in which X is O or NR.sup.11,Z is CH.sub.2, O, S or CHHal,R.sup.1 and R.sup.5 are each A,R.sup.2 is H or A,R.sup.1 and R.sup.2 together are also alkylene having 3-6 C atoms,R.sup.3 is OH or OAc,R.sup.4 is H,R.sup.3 and R.sup.4 together are also a bond,R.sup.6 and R.sup.7 are each H, A, HO, AO, CHO, ACO, ACS, HOOC, AOOC, AO--CS, ACOO, A--CS--O, hydroxyalkyl, NO.sub.2, NH.sub.2, NHA, NA.sub.2, CN, F, Cl, Br, I, CF.sub.3, ASO, ASO.sub.2, AO--SO, AO--SO.sub.2, AcNH, AO--CO--NH, H.sub.2 NSO, HANSO, A.sub.2 NSO, H.sub.2 NSO.sub.2, HANSO.sub.2, A.sub.2 NSO.sub.2, H.sub.2 NCO, HANCO, A.sub.2 NCO, H.sub.2 NCS, HANCS, A.sub.2 NCS, ASONH, ASO.sub.2 NH, AOSONH, AOSO.sub.2 NH, ACO-alkyl, nitro-alkyl, cyanoalkyl, A--C(.dbd.NOH) or A--C(.dbd.NNH.sub.2),R.sup.8 and R.sup.9 are each H or A or together are .dbd.O or .dbd.S,R.sup.10 is H, Hal, CHO or CH.sub.2 OH,R.sup.11 is H, A, Ac or CH.sub.Type: GrantFiled: April 20, 1992Date of Patent: August 3, 1993Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Manfred Baumgarth, Ingeborg Lues, Jacques De Peyer, Rolf Bergmann
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Patent number: 5223629Abstract: A process is disclosed for the preparation of (.+-.)-6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrol idino)-2H-1-benzopyran-3-ol of the Formula (VI) ##STR1## from 4-cyanophenol of the Formula (I) ##STR2## which comprises reacting 4-cyanophenol of the Formula (I) with isoprene, followed with bromination and dehydrobromination steps with formation of intermediates to react with 2-pyrrolidone resulting in obtaining the compound of the Formula (VI).Type: GrantFiled: December 17, 1991Date of Patent: June 29, 1993Assignee: Alkaloida Vegyeszeti GyarInventors: Tibor Timar, Tibor Eszenyi, Peter Sebok, Vilmos Galamb, Julia Fazekas, Terezia Istvan, Eva Kovach, Erika Nagy
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Patent number: 5190956Abstract: Compounds useful as antiviral agents against DNA containing viruses, such as herpes group viruses, are disclosed. The compounds are selected from the group consisting of: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.00 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1.00The compounds of Formula 1.00 are also useful as intermediates to compounds of: ##STR2## Compounds of Formula 1.0 are useful as antiviral agents against the same viruses that the compounds of Formula 1.00 are useful against.Type: GrantFiled: September 7, 1990Date of Patent: March 2, 1993Assignee: Schering CorporationInventors: Adriano Afonso, Jay Weinstein, Margaret J. Gentles
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Patent number: 5189183Abstract: Novel aromatic amine derivatives of specific structure are useful intermediates for herbicides. The aromatic amine compounds have the structure shown by formula [I]: ##STR1## wherein Ar and A are as defined herein.Type: GrantFiled: October 16, 1990Date of Patent: February 23, 1993Assignee: Mitsui Petrochemical Industries, Ltd.Inventors: Daisuke Fukuoka, Katsuya Takahashi, Isao Hashimoto
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Patent number: 5151442Abstract: Compounds of the formula ##STR1## in which: Z represents a halogen or a cyano, acetyl, trifluoroacetyl, nitro, C.sub.1 -C.sub.4 alkylthio, carboxyl, phosphono, dialkoxyphosphonyl or alkoxycarbonyl group, the alkylthio and alkoxy groups containing from 1 to 3 carbon atoms;R.sub.1 denotes a hydroxyl group and R.sub.2 represents hydrogen, or R.sub.1 and R.sub.2 taken together form an additional bond between the carbon atoms by which they are carried; andR.sub.3 representsa group NH--X--R.sub.4, in which X denotes a direct bond or an SO.sub.2 group and R.sub.4 represents a phenyl group which is unsubstituted or monosubstituted or disubstituted by a halogen, a nitro group, a C.sub.1 -C.sub.4 group, a trifluoromethyl group, an amino group, a group --N(Alk).sub.2, a group --COOAlk or a group OAlk, Alk denoting a C.sub.1 -C.sub.4 Alkyl group;a group --S--R.sub.5, in which R.sub.5 represents a C.sub.1 -C.sub.4 alkyl group, a C.sub.3 -C.sub.Type: GrantFiled: October 23, 1991Date of Patent: September 29, 1992Assignee: SanofiInventors: Georges Garcia, Alain Di Malta, Philippe Soubrie
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Patent number: 5125954Abstract: The present invention relates to novel bicyclo ether derivatives, to compositions containing them, and to their method of use especially to control the growth of undesired vegetation in rice.Type: GrantFiled: November 2, 1990Date of Patent: June 30, 1992Assignee: E.I. Du Pont de Nemours and CompanyInventors: James E. Powell, Richard B. Phillips
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Patent number: 5116954Abstract: Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S.fwdarw.(O).sub.n (n=0 or 2);R.sub.1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine, fluorine, diethylaminoethoxy, phenoxy, 2-methyl-4-thiazolyl, 2-amino-4-thiazolyl, phenyl, amino, nitro, terbutyl, carboxymethyl, acetamido, dimethyltriazenyl, benzoyl, hexyl, undecyl, trifluoromethyl, carbamoyl; or R.sub.1 is trifluoromethyl, pyridyl-2,pyridyl-4;R.sub.2 is H, methoxy, hydroxy; orR.sub.1 and R.sub.2 are --CH.dbd.CH--CH.dbd.CH--;R.sub.3 and R.sub.4 are methoxy, hydroxy, fluorine or form a fused benzene ring;CR.sub.5 R.sub.6 R.sub.7 is carboxymethyl, --CH.sub.2 --PO.sub.3 H,--CH.sub.2 --PO(oET).sub.2, 4-methylpiperazinyl, aminomethyl,3-4-5-trimethoxyphenylaminomethyl, acetyl, bromoacetyl, hydroxyethyl, acetoxyethyl, mercaptomethyl, acetylthiomethyl, methoxy-carbopnylthiomethyl, --CH--CONH.sub.2, ##STR2## substituted thiazolyl, subsituted furanone, imidazo(1,2-a)pyridinyl, indolizinyl, or R.sub.4 and R.Type: GrantFiled: August 2, 1989Date of Patent: May 26, 1992Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Philippe Briet, Jean-Jacques Berthelon, Francois Collonges
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Patent number: 5071871Abstract: New benz[b]pyranes and pyranopyridines of formula I, ##STR1## wherein the significances of substituents V, T, W, R.sub.3 to R.sub.5, R.sub.9, R.sub.10, m, X, Y and Z are given in claim 1 and their N-oxides and their salts and their use in the treatment of raised blood pressure in the treatment of vascular disorders and other disorders in which a reduction in tension of the smooth muscles is therapeutically useful, as well as in the treatment of hair loss and baldness. Further the compounds are useful in the treatment of asthma and obstructive disorders of the respiratory system as well as in the prophylactic treatment of obstructive or inflammatory airways disease, for example asthma, as well as novel pharmaceutical compositions comprising said K.sup.+ channel activators suitable for such use.Type: GrantFiled: July 10, 1990Date of Patent: December 10, 1991Assignee: Sandoz Ltd.Inventors: Stefan Blarer, John Morley, Ian D. Chapman
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Patent number: 5011950Abstract: Novel aromatic amine derivatives of specific structure are useful intermediates for herbicides. The aromatic amine compounds have the structure shown by formula [I]: ##STR1## wherein Ar and A are as defined herein.Type: GrantFiled: February 2, 1988Date of Patent: April 30, 1991Assignee: Mitsui Petrochemical Industries, Ltd.Inventors: Daisuke Fukuoka, Katsuya Takahashi, Isao Hashimoto
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Patent number: 4954518Abstract: This invention relates to a 4H-1-benzopyran-4-one derivative represented by the formula: ##STR1## or a salt thereof, a process for producing the same and a pharmaceutical composition comprising the same as active ingredient.Type: GrantFiled: October 7, 1988Date of Patent: September 4, 1990Assignee: Toyama Chemical Company, Ltd.Inventors: Shuntaro Takano, Chosaku Yoshida, Takihiro Inaba, Keiichi Tanaka, Ryuko Takeno, Hideyoshi Nagaki, Tomoya Shimotori, Shinji Makino
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Patent number: 4897402Abstract: Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by stuctural formulae (I) and (II): ##STR1## wherein A is O, S(O).sub.n or N--R.sub.13.Type: GrantFiled: June 29, 1988Date of Patent: January 30, 1990Assignee: Merck & Co., Inc.Inventors: Mark E. Duggan, George D. Hartman
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Patent number: 4838924Abstract: This invention relates to novel compounds of formula [I], a process for their production, and their use as a herbicide. ##STR1## wherein A represents the bond ##STR2## in which X is a hydrogen atom, a chlorine atom, a nitro group or a trifluoromethyl group;B represents a hydrogen atom, a methyl group or a methoxy group; andAr represents one member selected from the group consisting of ##STR3## in which R.sup.1 to R.sup.38, are as defined hereinafter.Type: GrantFiled: April 1, 1987Date of Patent: June 13, 1989Assignee: Mitsui Petrochemical Industries, Ltd.Inventors: Tetsuo Takematsu, Daisuke Fukuoka, Katsuya Takahashi, Isao Hashimoto
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Patent number: 4829080Abstract: An aromatic benzopyranyl or benzothiopyranyl compound of the formula ##STR1## wherein n is 0 or 1,X represents ##STR2## R' represents H, OH, acyloxy or NH.sub.2, R" represents H or alkoxy orR' and R" taken together form an oxo, methano or hydroxyimino radical,R.sub.8 represents H, ##STR3## R.sub.9 represents H, alkyl, mono or polyhydroxyalkyl, aryl, aralkyl, a residue of a sugar or ##STR4## p equals 1, 2 or 3, r' and r" represent H, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of an amino acid or an aminated sugar, or together form a heterocycle,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represents H or lower alkyl,R.sub.5, R.sub.6 and R.sub.7 represent H or methyl or when n=1, R.sub.5 and R.sub.7 taken together form with the benzene ring a naphthalene ring (R.sub.5 -R.sub.7 .dbd.--CH.dbd.CH--), andthe salts of said compounds as well as their geometric and optical isomers.These compounds are useful in pharmaceutical and cosmetic compositions.Type: GrantFiled: March 12, 1987Date of Patent: May 9, 1989Assignee: L'OrealInventors: Jean Maignan, Gerard Lang, Gerard Malle, Serge Restle, Braham Shroot
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Patent number: 4764508Abstract: The invention relates to novel compounds comprising lipophilic complexes of silybin, silidianin, and silicristin with phospholipids, and the preparation of these complexes by non-conventional methods. Absorption of the novel compounds in the gastrointestinal tract is appreciably greater, resulting in higher plasma levels than for the individual flavanolignans. The resulting improvement in the pharmacokinetic and pharmacological parameters is such that the substances can advantageously be used in the treatment of acute and chronic liver disease of toxic, metabolic or infective origin or of degenerative nature.Type: GrantFiled: July 7, 1986Date of Patent: August 16, 1988Assignee: Inverni Della Beffa S.p.A.Inventors: Bruno Gabetta, Ezio Bombardelli, Giorgio Pifferi
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Patent number: 4760088Abstract: Sulfide derivatives of catechins derived from condensed tannins have broad spectrum biocidal characteristics. Epicatechin-4-alkylsulfides and cupric complexes thereof containing up to 20, preferably 5 to 15, carbon atoms are particularly effective biocides against wood rotting fungi and gram-positive bacteria.Such sulfides are prepared by reacting condensed tannin, either in the form of a purified tannin extract or comminuted plant tissue, with an appropriate thiol under mild acidic conditions.Type: GrantFiled: September 15, 1986Date of Patent: July 26, 1988Assignee: Board of Control of Michigan Technological UniversityInventor: Peter E. Laks
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Patent number: 4665097Abstract: Novel bicyclooxyaryl thioureas are provided together with methods for their preparation and use as the active toxicant in pesticidal compositions.Type: GrantFiled: March 31, 1983Date of Patent: May 12, 1987Assignee: Union Carbide CorporationInventor: Paul A. Cain
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Patent number: 4665202Abstract: The invention relates to pharmaceutical preparations containing compounds of formula I ##STR1## in which X.sub.1 and X.sub.2, independently of each other, represent hydrogen, halogen, unsubstituted or substituted amino or a quaternary ammonium salt; etherified or esterified hydroxy; free, etherified, esterified or oxidized mercapto; nitro; functionally modified formyl; free or functionally modified carboxyl; acyl; an unsubstituted or substituted hydrocarbon radical, or an unsubstituted or substituted heterocyclic radical; with the proviso that at least one of the radicals X.sub.1 and X.sub.2 is bonded by a carbon atom to the ring system and with the proviso that X.sub.1 and X.sub.2 cannot be together halogen and formyl; in which Y represents oxygen, sulfur, sulfinyl or sulfonyl but must be sulfur, sulfinyl or sulfonyl, if X.sub.1 is hydrogen and X.sub.Type: GrantFiled: August 24, 1984Date of Patent: May 12, 1987Assignee: Zyma SAInventors: Christian G. Rimbault, Philippe M. Narbel
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Patent number: 4636575Abstract: Compounds of formula II and X ##STR1## wherein X is O, S, SO.sub.2, methylene, isopropylidene or NCOR.sub.7 where R.sub.7 is alkyl or phenyl, Y is a direct bond or methylene, n is 1 or 2, R.sub.4 is alkyl, phenyl, naphthyl, cycloalkyl, aralkyl, camphoryl, CF.sub.3, CCl.sub.3, F or NH.sub.2 ; or is alkylene, phenylene or naphthylene, R.sub.5 is hydrogen or halogen, R.sub.6 is hydrogen, alkyl, phenyl or cyano, R.sub.8 is substituted phenyl, substituted naphthyl, anthryl or phenanthryl, R.sub.9 is alkyl R.sub.10 is alkyl or substituted phenyl, and R.sub.11 is alkyl, substituted phenyl, naphthyl, camphoryl, alkylene, phenylene or naphthylene, are latent curing catalysts for acid-curable stoving lacquers. They are distinguished by satisfactory solubility in the acid-curable resin systems, can be stored virtually indefinitely in the dark and, when exposed to shortwave light, make it possible to cure the resins by acid catalysts at a relatively low temperature.Type: GrantFiled: December 17, 1984Date of Patent: January 13, 1987Assignee: Ciba-Geigy CorporationInventor: Rudolf Kirchmayr
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Patent number: 4609744Abstract: Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.Type: GrantFiled: March 19, 1984Date of Patent: September 2, 1986Assignee: Merck Frosst Canada Inc.Inventors: Robert N. Young, Joshua Rokach, Haydn R. Williams, Masatoshi Kakushima, Yvan Guindon
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2,4-diamino-(substituted-benzopyran(quinolyl,isoquinoly)methyl)pyrimidine s useful as antibacterials
Patent number: 4587342Abstract: Novel 2,4-diaminopyrimidines having substituted heterobicyclomethyl moieties in the 5-position have superior antibacterial properties.Type: GrantFiled: October 31, 1983Date of Patent: May 6, 1986Inventors: Susan M. Daluge, Paul M. Skonezny -
Patent number: 4477646Abstract: Novel piperazinoethyl ureas are prepared by reacting an aminoethyl piperazine with urea and recovering the monosubstituted urea product. These products are useful as curing agents for epoxy resins.Type: GrantFiled: August 24, 1983Date of Patent: October 16, 1984Assignee: The Dow Chemical CompanyInventor: Jimmy Myers
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Patent number: 4394382Abstract: A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,R.sub.1 represents a member selected from the group consisting of a C.sub.3 -C.sub.5 alkyl group, a hydroxy-(C.sub.3 -C.sub.5 alkyl) group, a lower alkylamino-lower alkyl group, a nitrato-(C.sub.3 -C.sub.5 alkyl) group and a phenyl-(C.sub.1 -C.sub.5) alkyl group, provided that the phenyl may be substituted by a lower alkoxy group, R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, NO.sub.2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group and acetyl group,R.sub.3 represents hydrogen or NO.sub.2,B represents a direct bond, a C.sub.1 -C.sub.7 alkylene group, a --O-lower alkylene group or a --CONH-lower alkylene group, andn represents 1 or 2;and an acid addition salt thereof and a pharmaceutical composition comprising aforesaid compound.Type: GrantFiled: June 9, 1981Date of Patent: July 19, 1983Assignee: Kowa Company, Ltd.Inventors: Masami Shiratsuchi, Noboru Shimizu, Hiromichi Shigyo, Yoshinori Kyotani, Hisashi Kunieda, Kiyoshi Kawamura, Seiichi Sato, Toshihiro Akashi, Masahiko Nagakura, Naotoshi Sawada, Yasumi Uchida
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Patent number: 4352792Abstract: Antiviral compositions containing 3-alkoxyflavone compounds as their active ingredients are disclosed.Type: GrantFiled: April 7, 1980Date of Patent: October 5, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Hideo Ishitsuka, Haruyoshi Shirai, Isao Umeda, Yasuji Suhara