Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/453)
  • Patent number: 9663432
    Abstract: The present invention relates to a monoalkenyl-containing glycerin derivative with purity of not less than 92% and electrical conductivity of not greater than 50 ?S/cm. The monoalkenyl-containing glycerin derivative can be manufactured by a manufacturing method comprising a step (A): a step of reacting a ketalized glycerin derivative and a monoalkenyl glycidyl ether in the presence of an inorganic base to obtain a ketal of monoalkenyl-containing glycerin derivative; a step (B): a step of purifying the ketal of monoalkenyl-containing glycerin derivative obtained in the step (A) by distillation; and a step (C): a step of hydrolyzing the ketal of monoalkenyl-containing glycerin derivative obtained in the step (B). The present invention is able to provide a high-purity monoalkenyl-containing glycerin derivative that was difficult in the past.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: May 30, 2017
    Assignee: DOW CORNING TORAY CO., LTD.
    Inventors: Tatsuo Souda, Sayuri Sawayama, Tsunehito Sugiura, Seiki Tamura, Seiji Hori
  • Patent number: 9328066
    Abstract: The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: May 3, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Peter Fey, Agathe Christine Mayer
  • Patent number: 9169277
    Abstract: The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: October 27, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy F. Jamison, Yutaka Ikeuchi
  • Patent number: 9039931
    Abstract: A liquid crystal composition including a dioxolane compound represented by the general formula (G1) as a chiral agent is provided. In the general formula (G1), R1 and R2 individually represent any of hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, an aryl group having 6 to 12 carbon atoms, and an alkyl group having 1 to 20 carbon atoms and having a phenyl group as a substituent; R1 and R2 may be bonded to each other to form a ring; R3 and R4 individually represent any of hydrogen, an alkyl group having 1 to 6 carbon atoms, and a cycloalkyl group; and R5 to R40 individually represent any of hydrogen, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, and an aryl group having 6 to 12 carbon atoms.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: May 26, 2015
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Tomohiro Tamura, Yasuhiro Niikura, Tetsuji Ishitani, Sachiko Kawakami, Yuko Kawata
  • Publication number: 20150141655
    Abstract: The present invention relates to processes for preparing protected glyceraldehydes, such as (hydroxy)methanesulfonates. In addition, the invention relates to thiadiazoles, particularly 3-diooxolanyl-thiadiazoles.
    Type: Application
    Filed: May 17, 2013
    Publication date: May 21, 2015
    Inventors: Eric A. Bercot, Matthew Bio, Johann Chan, John Colyer, Yuanqing Fang, Steven Mennen, Robert R. Milburn, Jason Tedrow, Babak Riahi
  • Publication number: 20150140493
    Abstract: A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed. Also described is a method for manufacturing a device, the method including applying a liquid containing a composition to a member such that a coating film including the composition is formed on the member; and exposing the coating film to at least one of a first electromagnetic ray and a first particle ray such that a first portion of the coating film is exposed to the at least one of the first electromagnetic ray and the first particle ray while a second portion of the coating film is not exposed to the at least one of the first electromagnetic ray and the first particle ray.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 21, 2015
    Inventors: Satoshi ENOMOTO, Yusuke SUGA
  • Publication number: 20150113860
    Abstract: The object of the present invention relates to a composition that can be used as fuel comprising: at least one hydrocarbon mixture at least one hydrophobic ketal or acetal of glycerine. Said composition can be advantageously used as fuel for diesel or gasoline engines.
    Type: Application
    Filed: April 3, 2013
    Publication date: April 30, 2015
    Applicant: ENI S.p.A.
    Inventors: Alberto De Angelis, Giulio Assanelli, Paolo Pollesel
  • Publication number: 20150076402
    Abstract: A dioxolane derivative represented by formula (G1) is provided. The explanation of the substituents is given in the specification. The use of the dioxolane derivative enables the production of a liquid crystal composition and a liquid crystal display device including the liquid crystal composition.
    Type: Application
    Filed: July 30, 2014
    Publication date: March 19, 2015
    Inventors: Momoko KATO, Yasuhiro Niikura, Tetsuji Ishitani, Yuko Kawata
  • Patent number: 8969598
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Eastman Chemical Company
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20140288319
    Abstract: The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products.
    Type: Application
    Filed: October 16, 2013
    Publication date: September 25, 2014
    Applicant: California Institute Of Technology
    Inventors: Robert H. GRUBBS, Arnab K. CHATTERJEE, Tae-Lim CHOI, Steven D. GOLDBERG, Jennifer A. LOVE, John P. MORGAN, Daniel P. SANDERS, Matthias SCHOLL, F. Dean TOSTE, Tina M. TRNKA
  • Publication number: 20140235878
    Abstract: A process for the production of dioxolane compounds of formula (I): wherein R1 and R2 independently represent hydrogen or an alkyl chain from 1 to 10 carbon atoms; R3 and R4 independently represent hydrogen, an alkyl chain from 1 to 5 carbon atoms, or an alkyl chain from 1 to 5 carbon atoms which is endowed with one or more hydroxyl groups, such process comprising a reaction between crude glycerol and an aldehyde or a ketone, with a molar ratio of aldehyde:glycerol or ketone:glycerol from 3:1 to 20:1.
    Type: Application
    Filed: September 30, 2011
    Publication date: August 21, 2014
    Applicant: RHODIA POLIAMIDA E ESPECIALIDADES LTDA
    Inventors: Edson Rodrigues, Arthur Malheiro
  • Publication number: 20140228339
    Abstract: There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 14, 2014
    Applicant: AstraZeneca AB
    Inventors: Stephen Connolly, Mark Richard Ebden, Iain Alastair Stewart Walters, Thomas Langer, Alan Robert Steven, Craig Robert Stewart, Paula Margaret Tomlin, Andrew John Williams
  • Publication number: 20140228584
    Abstract: A process for the production of dioxolane compounds of formula (I), wherein R1 and R2 independently represent hydrogen or an alkyl chain from 1 to 10 carbon atoms; R3 and R4 independently represent hydrogen, an alkyl chain from 1 to 5 carbon atoms or an alkyl chain from 1 to 5 carbon atoms endowed with one or more hydroxyl groups. Such process comprises successively a reaction step between crude glycerol and aldehyde or ketone and a liquid-liquid extraction step with an extracting ketonic solvent corresponding to formula (II) with A and B independently being an alkyl chain with 2 to 10 carbon atoms, or phenyl, A and B not comprising hydroxyl functions.
    Type: Application
    Filed: September 30, 2011
    Publication date: August 14, 2014
    Applicant: RHODIA POLIAMIDA E ESPECIALIDADES LTDA
    Inventors: Edson Rodrigues, Arthur Malheiro
  • Patent number: 8765979
    Abstract: The present invention relates to an improved process for the preparation of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane-4-methanol methanesulfonate(ester), a key intermediate for the preparation of the apoB secretion/MTP inhibitor mitratapide.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: July 1, 2014
    Assignee: Janssen Pharmaceutica
    Inventors: Walter Ferdinand Maria Filliers, Walter Louis Antoine Verstappen, Ronny Bellinkx
  • Publication number: 20140155637
    Abstract: The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.
    Type: Application
    Filed: May 24, 2012
    Publication date: June 5, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Peter Fey, Agathe Christine Mayer
  • Patent number: 8716334
    Abstract: Novel substituted cyclohexylidene-ethylidene-octahydro-indene compounds and compositions comprising the same are described. The compounds exhibit profound anti-proliferative effects, in comparison to other compounds known for their anti-cancer and anti-hyperproliferative ability. Methods of use of such compounds and compositions are described for treating a variety of cancers, inflammatory and other hyperproliferative diseases and disorders.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: May 6, 2014
    Assignee: Ben Gurion University of the Negev Research and Development Authority
    Inventors: Shimon Ben Shabat, Amnou Sintov
  • Patent number: 8703977
    Abstract: The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds, methods of synthesizing the intermediate compounds, and the like.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: April 22, 2014
    Assignee: Emory University
    Inventors: Matthew A. Boone, Frank E. McDonald
  • Patent number: 8680303
    Abstract: The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 25, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy F. Jamison, Yutaka Ikeuchi
  • Patent number: 8668964
    Abstract: A novel dioxolane compound represented by the general formula (G1) is provided. In the general formula (G1), R1 and R2 separately represent any of hydrogen, an alkylene group having 1 to 6 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, an aryl group having 6 to 12 carbon atoms, and an alkylene group having 1 to 20 carbon atoms and a phenyl group as a substituent; a1 and a2 separately represent any of an alkylene group having 1 to 4 carbon atoms and a single bond; Ar1 and Ar2 separately represent an aryl group having 6 to 16 carbon atoms; and R3 to R38 separately represent any of hydrogen, an alkylene group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, and an aryl group having 6 to 12 carbon atoms.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: March 11, 2014
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Momoko Kato, Yuko Kawata, Tetsuji Ishitani, Yasuhiro Niikura
  • Patent number: 8669260
    Abstract: The application discloses ketoconazole derivatives that are antagonists of the human pregnane X receptor (PXR), methods of preparing the derivatives, uses of the derivatives with drug therapy, and methods of inhibiting tumor cell proliferation and multidrug resistance using inhibitors of PXR.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: March 11, 2014
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Sridhar Mani, Bhaskar C. Das
  • Publication number: 20140057778
    Abstract: The present invention relates to a novel sulfonated carbon silica (SCS) composite material and a process for the preparation thereof. The synthesized SCS composite material on calcination yields the hierarchical mesoporous silica (MS) and further finds application as catalyst in two industrially important reactions namely phenol butylation and glycerol acetalization.
    Type: Application
    Filed: September 20, 2012
    Publication date: February 27, 2014
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: NAGABHATLA VISWANADHAM, DEVAKI NANDAN
  • Patent number: 8632792
    Abstract: A cooling sensation agent composition with a prolonged cool sensation effect is provided comprising at least one compound selected from the group consisting of aceia or ketal derivatives of 3-(1-menthoxy)propan-1,2-diol represented by Formula (1), single or mixed carbonic esters ol one or two kinds ol alcohols represented by Formula (2), and carboxylic esters represented by Formula (4). A sensory stimulation agoni composition, a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent; and new compounds are also provided.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: January 21, 2014
    Assignee: Takasago International Corporation
    Inventors: Kenya Ishida, Takashi Aida, Tetsuya Yamamoto
  • Publication number: 20130345107
    Abstract: The present invention relates to a solvent for cleaning textiles or clothes. The present invention provides a solvent for cleaning which has a specified formula that is safe on the human body and environment, as well as good cleaning ability against oil-based and water-based contaminants and can be quickly dried. The solvent of the present invention and a composition comprising the same can be effectively used to water clean or dry clean textiles or clothes at home.
    Type: Application
    Filed: December 15, 2011
    Publication date: December 26, 2013
    Applicant: LG HOUSEHOLD & HEALTH CARE LTD.
    Inventors: Seong-Kil Son, Kyoung-Hee Oh, Hyo-Seon Kim, Jung-Jin Choi, Sug-Youn Chang
  • Publication number: 20130345443
    Abstract: A fluorosulfonyl group-containing monomer having a high polymerization reactivity and plural fluorosulfonyl groups, a fluorosulfonyl group-containing polymer and a sulfonic acid group-containing polymer, obtained by using the monomer.
    Type: Application
    Filed: August 30, 2013
    Publication date: December 26, 2013
    Applicant: Asahi Glass Company, Limited
    Inventors: Atsushi WATAKABE, Hiromasa Yamamoto, Masao Iwaya, Susumu Saito
  • Publication number: 20130338380
    Abstract: The invention described herein pertains to processes and compounds useful in the preparation of bis-tetrahydrofurans. The invention described herein also pertains to compounds useful for treating HIV infections.
    Type: Application
    Filed: November 30, 2011
    Publication date: December 19, 2013
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Arun K. Ghosh, Cuthbert D. Martyr
  • Patent number: 8575371
    Abstract: Glyceryl ether compounds prepared by the reaction of glycerol and olefin epoxides are disclosed. The compounds are renewable biomass-based surfactants useful as detergents and emulsifiers in formulations for cleaning, laundry, personal care, cosmetics, and industrial uses.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: November 5, 2013
    Assignee: Segetis, Inc.
    Inventor: Sergey Selifonov
  • Patent number: 8513443
    Abstract: The present invention relates to the preparation of (R)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide.
    Type: Grant
    Filed: July 10, 2010
    Date of Patent: August 20, 2013
    Assignee: Ardea Biosciences, Inc.
    Inventors: Andreas Maderna, Jean-Michel Vernier
  • Publication number: 20130178638
    Abstract: A process is described for producing dioxolane from crude glycerol obtained from raw materials such as the crude glycerol obtained during production of biodiesel or glycerol obtained during conversion of fats or oils. Further, the described method can dissolve the glycerol in an organic solvent and form an insoluble phase including salts included in the crude glycerol, and then react the glycerol obtained with an aldehyde or a ketone.
    Type: Application
    Filed: September 7, 2011
    Publication date: July 11, 2013
    Applicant: RHODIA OPERATIONS
    Inventor: Sergio Mastroianni
  • Publication number: 20130134353
    Abstract: A novel dioxolane compound represented by the general formula (G1) is provided. In the general formula (G1), R1 and R2 separately represent any of hydrogen, an alkylene group having 1 to 6 carbon atoms, an alkoxy group having 1 to 20 carbon atoms, an aryl group having 6 to 12 carbon atoms, and an alkylene group having 1 to 20 carbon atoms and a phenyl group as a substituent; a1 and a2 separately represent any of an alkylene group having 1 to 4 carbon atoms and a single bond; Ar1 and Ar2 separately represent an aryl group having 6 to 16 carbon atoms; and R3 to R38 separately represent any of hydrogen, an alkylene group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, and an aryl group having 6 to 12 carbon atoms.
    Type: Application
    Filed: November 27, 2012
    Publication date: May 30, 2013
    Applicant: SEMICONDUCTOR ENGERGY LABORATORY CO., LTD
    Inventor: SEMICONDUCTOR ENGERGY LABORATORY C
  • Patent number: 8420294
    Abstract: The present invention provides a salt represented by the formula (I): wherein R1 and R2 independently each represent a C1-C6 alkyl group or R1 and R2 are bonded each other to form a C5-C20 aliphatic ring together with the carbon atom to which they are bonded, R3 and R4 independently each represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO— and which may be substituted with one or more fluorine atoms, and Z1+ represents an organic counter ion.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: April 16, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Ichikawa, Yukako Anryu, Shingo Fujita
  • Publication number: 20130046102
    Abstract: Glyceryl ether compounds prepared by the reaction of glycerol and olefin epoxides are disclosed. The compounds are renewable biomass-based surfactants useful as detergents and emulsifiers in formulations for cleaning, laundry, personal care, cosmetics, and industrial uses.
    Type: Application
    Filed: October 22, 2012
    Publication date: February 21, 2013
    Applicant: SEGETIS, INC.
    Inventor: SEGETIS, INC.
  • Publication number: 20130040926
    Abstract: There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
    Type: Application
    Filed: July 11, 2012
    Publication date: February 14, 2013
    Inventors: Stephen CONNOLLY, Mark Richard EBDEN, Iain Alastair Stewart WALTERS, Thomas LANGER, Alan Robert STEVEN, Craig Robert STEWART, Paula Margaret TOMLIN, Andrew John WILLIAMS
  • Patent number: 8349777
    Abstract: Disclosed are lubricating oil compositions comprising a major amount of an oil of lubricating viscosity; and from 0.05 to 10 weight % based upon the total lubricating oil composition of a 1,3-dioxolane-4-methanol compound of the formula I: wherein: R1 and R2 are each independently hydrogen, alkyl or alkenyl, wherein the sum of carbon atoms for R1 and R2 is 6 carbon atoms or less.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: January 8, 2013
    Assignee: Chevron Oronite Company LLC
    Inventor: Patrick J. McDougall
  • Publication number: 20130005991
    Abstract: The present invention relates to a process for preparing 1-O-acyl-2-deoxy-2-fluoro-4-thio-?-D-arabinofuranoses having formula I and intermediates thereof: wherein R1 represents —C(O)—C1-C6-alkyl or —C(O)-aryl; and R2 represents C1-C6-alkyl, C1-C4-perfluoroalkyl or aryl.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 3, 2013
    Applicant: LibraMedicina, Inc.
    Inventors: David VOIGTLÄNDER, Michael SANDER, Michael HARRE
  • Publication number: 20120330033
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Patent number: 8338625
    Abstract: A method of producing a corresponding acetal compound which comprises reacting a benzal halide compound represented by formula (1) (wherein, Q represents a hydrogen atom or a halogen atom, X represents a halogen atom, and Ar represents a phenyl group optionally substituted with at least one group selected from the group consisting of alkyl groups having 1 to 4 carbon atoms and halogen atoms.) and an alcohol compound in the presence of at least one alkaline earth metal compound selected from the group consisting of alkaline earth metal oxides, alkaline earth metal hydroxides and alkaline earth metal carbonates.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: December 25, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yoshio Onogawa, Kazuyoshi Yamanaka, Masaji Hirota
  • Publication number: 20120223268
    Abstract: Uses of dioxolane derivatives in the finishing of leather are described. Also described, are leather finishing compositions comprising dioxolane derivatives and methods for treating leather.
    Type: Application
    Filed: August 31, 2010
    Publication date: September 6, 2012
    Applicant: RHODIA POLIAMIDA E ESPECIALIDADES LTDA
    Inventors: Daniela Bonifacio Hauffe, Jose Denilson Vicentim, Paulo Robert Garbelotto
  • Patent number: 8258323
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: September 4, 2012
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
  • Publication number: 20120219512
    Abstract: The invention relates to a sensory stimulant composition containing one or more of vanillin acetals represented by the general formula (1), and a flavor and fragrance composition, a beverage or food product, a fragrance or cosmetic product, a daily utensil product, an oral composition, or a pharmaceutical product containing the sensory stimulant composition with a warming sensation agent or cooling sensation substance, if necessary. Vanillin acetals represented by the general formula (1) show an excellent pungent and/or warming sensation effect and a cooling sensation-emphasizing effect.
    Type: Application
    Filed: May 9, 2012
    Publication date: August 30, 2012
    Applicant: Takasago International Corporation
    Inventors: Kenya ISHIDA, Takashi Aida
  • Publication number: 20120184443
    Abstract: Described are alkoxylated glycerol acetals according to Formulas (Ia) and (Ib) wherein R1 represents a linear or branched, saturated or unsaturated and optionally substituted hydrocarbyl residue comprising 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, a benzyl or furfuryl radical, R2 is selected from hydrogen, an alkyl, alkenyl or hydroxyalkyl group having 6 to 22 carbon atoms or an acyl group having 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, AO represents an ethylene oxide, a propylene oxide, a butylene oxide unit, or their mixtures, and n is an integer of about 1 to about 100.
    Type: Application
    Filed: September 23, 2010
    Publication date: July 19, 2012
    Applicant: Cognis IP Management GmbH
    Inventors: Ingo Fleute-Schlachter, Sandra Heldt, Peter Kempers, Ulrich Schörken, Eckhard Paetzold, Udo Kragl
  • Publication number: 20120178946
    Abstract: The present invention relates to the preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide.
    Type: Application
    Filed: July 10, 2010
    Publication date: July 12, 2012
    Applicant: ARDEA BIOSCIENCES ,INC.
    Inventors: Andreas Maderna, Jean-Michel Vernier
  • Publication number: 20120165548
    Abstract: Processes for the preparation of Silodosin and its intermediates comprising reductive amination of compound of Formula (VIII) with a compound of Formula (VII) or a compound of Formula (XV) in a suitable solvent using a reducing agent.
    Type: Application
    Filed: September 13, 2010
    Publication date: June 28, 2012
    Applicant: SANDOZ AG
    Inventors: Shreerang Joshi, Sachin Bhuta, Sanjay Talukdar, Sudhir Sawant, Deepak Venkataraman, Abhinay Pise, Shashikant Metkar, Dattatraya Chavan, Parven Kumar Luthra
  • Publication number: 20120135351
    Abstract: The present invention provides a salt represented by the formula (I): wherein R1 and R2 independently each represent a C1-C6 alkyl group or R1 and R2 are bonded each other to form a C5-C20 aliphatic ring together with the carbon atom to which they are bonded, R3 and R4 independently each represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO— and which may be substituted with one or more fluorine atoms, and Z1+ represents an organic counter ion.
    Type: Application
    Filed: November 25, 2011
    Publication date: May 31, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Koji ICHIKAWA, Yukako ANRYU, Shingo FUJITA
  • Publication number: 20120035170
    Abstract: This invention concerns novel substituted unsaturated tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonine receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in claim 1.
    Type: Application
    Filed: August 22, 2011
    Publication date: February 9, 2012
    Inventors: José Maria Núñez, Antonius Adrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez
  • Publication number: 20120035196
    Abstract: [Problem] The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes. [Means for Solution] The present inventors have extensively studied a compound having a GPR40 agonistic activity, and as a result, they have found that the compound (I) of the present invention or a pharmaceutically acceptable salt thereof, in which a carboxylic acid is bonded to a bicyclic or tricyclic moiety through methylene, and further, a benzene ring substituted with a monocyclic 6-membered aromatic ring is bonded to a bicyclic or tricyclic moiety through —O-methylene or —NH-methylene, has an excellent GPR40 agonistic activity. They have also found that the compound has an excellent insulin secretion promoting action and strongly inhibits increase in the blood glucose after glucose loading, thereby completing the present invention.
    Type: Application
    Filed: April 21, 2010
    Publication date: February 9, 2012
    Inventors: Kenji Negoro, Kei Ohnuki, Yasuhiro Yonetoku, Kazuyuki Kuramoto, Yasuharu Urano, Hideyuki Watanabe
  • Publication number: 20110312904
    Abstract: The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).
    Type: Application
    Filed: August 27, 2009
    Publication date: December 22, 2011
    Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Samuel J. Danishefsky, Ting-Chao Chou, Xiaoguang Lei, Heedong Yun, Fay Ng, John Hartung, Dalibor Sames
  • Publication number: 20110288315
    Abstract: A 2-aryl-2-halomethyl-4-chloromethyl-1,3-dioxolane (A) can be produced conveniently without decreasing its optical purity by reacting an optically active monochlorohydrin and an aryl (halomethyl) ketone (starting materials) with each other in the presence of an acid catalyst. From the optically active compound (A) thus produced, an optically active carboxylic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester and an optically active sulfonic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester (both of which are useful intermediates for the production of ketoconazole) can be produced with good efficiency. An optically active trans-carboxylic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester can be isomerized into its cis-form in the presence of an acid catalyst.
    Type: Application
    Filed: March 23, 2009
    Publication date: November 24, 2011
    Applicant: DAISO CO., LTD.
    Inventors: Yutaka Ishii, Shingo Iwashina, Takahiro Kawase, Yumiko Matsui
  • Publication number: 20110275839
    Abstract: The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds, methods of synthesizing the intermediate compounds, and the like.
    Type: Application
    Filed: December 30, 2009
    Publication date: November 10, 2011
    Applicant: EMORY UNIVERSITY
    Inventors: Matthew A. Boone, Frank E. McDonald
  • Publication number: 20110201831
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Application
    Filed: April 29, 2011
    Publication date: August 18, 2011
    Applicant: ZACH SYSTEM S.P.A.
    Inventors: Raffaella VOLPICELLI, Paolo MARAGNI, Livius COTARCA, Johnny FOLETTO, Franco MASSACCESI
  • Patent number: 7999124
    Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: August 16, 2011
    Assignee: Zach System S.p.A.
    Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi